

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA double-strand break processing (GO:0000729) | 4.79837766 |
| 2 | chromatin remodeling at centromere (GO:0031055) | 4.48768292 |
| 3 | CENP-A containing nucleosome assembly (GO:0034080) | 4.44141311 |
| 4 | proteasome assembly (GO:0043248) | 4.35026365 |
| 5 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.26323384 |
| 6 | protein complex biogenesis (GO:0070271) | 3.87491224 |
| 7 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.81444807 |
| 8 | histone exchange (GO:0043486) | 3.77987614 |
| 9 | establishment of integrated proviral latency (GO:0075713) | 3.76814658 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.73599294 |
| 11 | cullin deneddylation (GO:0010388) | 3.68480214 |
| 12 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.67910042 |
| 13 | NADH dehydrogenase complex assembly (GO:0010257) | 3.67910042 |
| 14 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.67910042 |
| 15 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.66858784 |
| 16 | DNA ligation (GO:0006266) | 3.64751635 |
| 17 | protein neddylation (GO:0045116) | 3.64623359 |
| 18 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.63362885 |
| 19 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.63107356 |
| 20 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.61870785 |
| 21 | respiratory chain complex IV assembly (GO:0008535) | 3.61365767 |
| 22 | ATP synthesis coupled proton transport (GO:0015986) | 3.61305976 |
| 23 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.61305976 |
| 24 | kinetochore organization (GO:0051383) | 3.52969038 |
| 25 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.51652718 |
| 26 | replication fork processing (GO:0031297) | 3.49403057 |
| 27 | kinetochore assembly (GO:0051382) | 3.49343451 |
| 28 | DNA damage response, detection of DNA damage (GO:0042769) | 3.48962191 |
| 29 | DNA replication-independent nucleosome organization (GO:0034724) | 3.46794504 |
| 30 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.46794504 |
| 31 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.45557552 |
| 32 | resolution of meiotic recombination intermediates (GO:0000712) | 3.37452173 |
| 33 | cytochrome complex assembly (GO:0017004) | 3.32357528 |
| 34 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.30167003 |
| 35 | protein deneddylation (GO:0000338) | 3.29131994 |
| 36 | purine nucleobase biosynthetic process (GO:0009113) | 3.26600329 |
| 37 | maturation of 5.8S rRNA (GO:0000460) | 3.26428869 |
| 38 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.23545262 |
| 39 | negative regulation of ligase activity (GO:0051352) | 3.23545262 |
| 40 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.22273224 |
| 41 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.19501862 |
| 42 | rRNA modification (GO:0000154) | 3.18503644 |
| 43 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.17197195 |
| 44 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.17197195 |
| 45 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.16969336 |
| 46 | regulation of helicase activity (GO:0051095) | 3.16936008 |
| 47 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.15172952 |
| 48 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.14955120 |
| 49 | mitotic recombination (GO:0006312) | 3.11244659 |
| 50 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.08670689 |
| 51 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.08670689 |
| 52 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.07465435 |
| 53 | termination of RNA polymerase III transcription (GO:0006386) | 3.07465435 |
| 54 | chaperone-mediated protein transport (GO:0072321) | 3.06380773 |
| 55 | V(D)J recombination (GO:0033151) | 3.06333517 |
| 56 | protein K6-linked ubiquitination (GO:0085020) | 3.05859151 |
| 57 | mismatch repair (GO:0006298) | 3.05638151 |
| 58 | regulation of mitochondrial translation (GO:0070129) | 3.04448367 |
| 59 | histone mRNA metabolic process (GO:0008334) | 3.04023433 |
| 60 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.01234582 |
| 61 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.00537115 |
| 62 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.00537115 |
| 63 | spliceosomal snRNP assembly (GO:0000387) | 3.00424971 |
| 64 | DNA strand elongation (GO:0022616) | 2.98722965 |
| 65 | telomere maintenance via recombination (GO:0000722) | 2.92991430 |
| 66 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.90272049 |
| 67 | pseudouridine synthesis (GO:0001522) | 2.90169101 |
| 68 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.89783158 |
| 69 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.89783158 |
| 70 | DNA deamination (GO:0045006) | 2.89149840 |
| 71 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.88355554 |
| 72 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.88355554 |
| 73 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.88355554 |
| 74 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.87722204 |
| 75 | DNA topological change (GO:0006265) | 2.87630168 |
| 76 | DNA replication checkpoint (GO:0000076) | 2.86672300 |
| 77 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.85670989 |
| 78 | histone H2A acetylation (GO:0043968) | 2.85506147 |
| 79 | establishment of viral latency (GO:0019043) | 2.85292286 |
| 80 | nucleobase biosynthetic process (GO:0046112) | 2.84675736 |
| 81 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.84627121 |
| 82 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.84624487 |
| 83 | recombinational repair (GO:0000725) | 2.84290686 |
| 84 | oxidative phosphorylation (GO:0006119) | 2.84266731 |
| 85 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.82562044 |
| 86 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.82562044 |
| 87 | negative regulation of thymocyte apoptotic process (GO:0070244) | 2.82105093 |
| 88 | postreplication repair (GO:0006301) | 2.81320823 |
| 89 | respiratory electron transport chain (GO:0022904) | 2.80462782 |
| 90 | double-strand break repair via homologous recombination (GO:0000724) | 2.80019611 |
| 91 | electron transport chain (GO:0022900) | 2.77678185 |
| 92 | negative regulation of DNA recombination (GO:0045910) | 2.77666196 |
| 93 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.75525601 |
| 94 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.75525601 |
| 95 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.75525601 |
| 96 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.75525601 |
| 97 | negative regulation of sister chromatid segregation (GO:0033046) | 2.75525601 |
| 98 | DNA integration (GO:0015074) | 2.74356507 |
| 99 | somatic diversification of immune receptors (GO:0002200) | 2.74207124 |
| 100 | positive regulation of ligase activity (GO:0051351) | 2.74116148 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.52788157 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.02202228 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.84448426 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.70010147 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.56337565 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.30223645 |
| 7 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.06311588 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.84656103 |
| 9 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.79639592 |
| 10 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.67077286 |
| 11 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.65188087 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.46590514 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.46251304 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.40459293 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.33247903 |
| 16 | EWS_26573619_Chip-Seq_HEK293_Human | 2.31870722 |
| 17 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.25112828 |
| 18 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.24927188 |
| 19 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.20521514 |
| 20 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.16542918 |
| 21 | FUS_26573619_Chip-Seq_HEK293_Human | 2.14630335 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.09232906 |
| 23 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.06706965 |
| 24 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.00216669 |
| 25 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.98274835 |
| 26 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.92693752 |
| 27 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.86447009 |
| 28 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.81600038 |
| 29 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.79240392 |
| 30 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.77242204 |
| 31 | VDR_22108803_ChIP-Seq_LS180_Human | 1.74772014 |
| 32 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.73492113 |
| 33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.72700480 |
| 34 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.67126445 |
| 35 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.56997819 |
| 36 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.56255998 |
| 37 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.55895365 |
| 38 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.54843892 |
| 39 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.54801042 |
| 40 | P300_19829295_ChIP-Seq_ESCs_Human | 1.54704309 |
| 41 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.53223420 |
| 42 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.48345601 |
| 43 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.47586514 |
| 44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.47246340 |
| 45 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.41808628 |
| 46 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.41435427 |
| 47 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.39711036 |
| 48 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.37966258 |
| 49 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.34020476 |
| 50 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.33541577 |
| 51 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.33074747 |
| 52 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.32223548 |
| 53 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.30712367 |
| 54 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.30239686 |
| 55 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.29570441 |
| 56 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.29174870 |
| 57 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.28248754 |
| 58 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.24736545 |
| 59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.23504205 |
| 60 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.23452658 |
| 61 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.21865913 |
| 62 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.21672876 |
| 63 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.21618881 |
| 64 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.21522998 |
| 65 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.20750456 |
| 66 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.19863459 |
| 67 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.18933758 |
| 68 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.15983290 |
| 69 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.15776521 |
| 70 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.14781848 |
| 71 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.14238422 |
| 72 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.12077233 |
| 73 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.10895713 |
| 74 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.07130264 |
| 75 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.05879978 |
| 76 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.03643744 |
| 77 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.02698082 |
| 78 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.00515564 |
| 79 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.00515564 |
| 80 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.00224263 |
| 81 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.99807332 |
| 82 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.99432352 |
| 83 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.96691891 |
| 84 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.96506289 |
| 85 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.96081032 |
| 86 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.96081032 |
| 87 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.96005894 |
| 88 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.95153662 |
| 89 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.94191911 |
| 90 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.92586599 |
| 91 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.89349002 |
| 92 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.88890945 |
| 93 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.88631837 |
| 94 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.85285232 |
| 95 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.85078472 |
| 96 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.85078472 |
| 97 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.83264495 |
| 98 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.82861434 |
| 99 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.82745796 |
| 100 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.81855286 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.74672090 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.71782796 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.43869446 |
| 4 | MP0006292_abnormal_olfactory_placode | 3.26563693 |
| 5 | MP0003718_maternal_effect | 2.52663750 |
| 6 | MP0008789_abnormal_olfactory_epithelium | 2.49555720 |
| 7 | MP0002102_abnormal_ear_morphology | 2.47147831 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.43369118 |
| 9 | MP0006072_abnormal_retinal_apoptosis | 2.39741711 |
| 10 | MP0004957_abnormal_blastocyst_morpholog | 2.23559216 |
| 11 | MP0009697_abnormal_copulation | 2.22210866 |
| 12 | MP0001529_abnormal_vocalization | 2.13418181 |
| 13 | MP0005084_abnormal_gallbladder_morpholo | 2.06875357 |
| 14 | MP0003111_abnormal_nucleus_morphology | 2.02404451 |
| 15 | MP0001293_anophthalmia | 2.01038008 |
| 16 | MP0002736_abnormal_nociception_after | 1.95650800 |
| 17 | MP0005499_abnormal_olfactory_system | 1.90286569 |
| 18 | MP0005394_taste/olfaction_phenotype | 1.90286569 |
| 19 | MP0008007_abnormal_cellular_replicative | 1.86983523 |
| 20 | MP0003077_abnormal_cell_cycle | 1.85192569 |
| 21 | MP0004147_increased_porphyrin_level | 1.78413859 |
| 22 | MP0008932_abnormal_embryonic_tissue | 1.78384893 |
| 23 | MP0003787_abnormal_imprinting | 1.76884482 |
| 24 | MP0003567_abnormal_fetal_cardiomyocyte | 1.72440289 |
| 25 | MP0002938_white_spotting | 1.69076561 |
| 26 | MP0008057_abnormal_DNA_replication | 1.60538294 |
| 27 | MP0000372_irregular_coat_pigmentation | 1.53244502 |
| 28 | MP0002234_abnormal_pharynx_morphology | 1.52234556 |
| 29 | MP0003136_yellow_coat_color | 1.51558220 |
| 30 | MP0003121_genomic_imprinting | 1.50557981 |
| 31 | MP0005253_abnormal_eye_physiology | 1.49308129 |
| 32 | MP0006036_abnormal_mitochondrial_physio | 1.48334499 |
| 33 | MP0003011_delayed_dark_adaptation | 1.45718681 |
| 34 | MP0001968_abnormal_touch/_nociception | 1.42808597 |
| 35 | MP0003786_premature_aging | 1.41929643 |
| 36 | MP0008995_early_reproductive_senescence | 1.41360744 |
| 37 | MP0005075_abnormal_melanosome_morpholog | 1.40543442 |
| 38 | MP0003195_calcinosis | 1.36279051 |
| 39 | MP0002751_abnormal_autonomic_nervous | 1.33681838 |
| 40 | MP0001984_abnormal_olfaction | 1.32823991 |
| 41 | MP0000516_abnormal_urinary_system | 1.31490989 |
| 42 | MP0005367_renal/urinary_system_phenotyp | 1.31490989 |
| 43 | MP0002132_abnormal_respiratory_system | 1.29742413 |
| 44 | MP0003890_abnormal_embryonic-extraembry | 1.27385119 |
| 45 | MP0000631_abnormal_neuroendocrine_gland | 1.26927294 |
| 46 | MP0003186_abnormal_redox_activity | 1.25101552 |
| 47 | MP0003283_abnormal_digestive_organ | 1.22140127 |
| 48 | MP0002138_abnormal_hepatobiliary_system | 1.21248922 |
| 49 | MP0006276_abnormal_autonomic_nervous | 1.20953355 |
| 50 | MP0001485_abnormal_pinna_reflex | 1.20229781 |
| 51 | MP0005646_abnormal_pituitary_gland | 1.17571735 |
| 52 | MP0003806_abnormal_nucleotide_metabolis | 1.14745547 |
| 53 | MP0002233_abnormal_nose_morphology | 1.13913004 |
| 54 | MP0004885_abnormal_endolymph | 1.13014537 |
| 55 | MP0004133_heterotaxia | 1.12824402 |
| 56 | MP0002638_abnormal_pupillary_reflex | 1.12609763 |
| 57 | MP0008872_abnormal_physiological_respon | 1.12415017 |
| 58 | MP0000049_abnormal_middle_ear | 1.11630757 |
| 59 | MP0005551_abnormal_eye_electrophysiolog | 1.11615965 |
| 60 | MP0005645_abnormal_hypothalamus_physiol | 1.10152882 |
| 61 | MP0006035_abnormal_mitochondrial_morpho | 1.08852406 |
| 62 | MP0001929_abnormal_gametogenesis | 1.08713028 |
| 63 | MP0001286_abnormal_eye_development | 1.03332569 |
| 64 | MP0002210_abnormal_sex_determination | 1.01359008 |
| 65 | MP0003937_abnormal_limbs/digits/tail_de | 0.98955956 |
| 66 | MP0000653_abnormal_sex_gland | 0.98522365 |
| 67 | MP0004215_abnormal_myocardial_fiber | 0.97652812 |
| 68 | MP0002396_abnormal_hematopoietic_system | 0.97187498 |
| 69 | MP0001145_abnormal_male_reproductive | 0.95226143 |
| 70 | MP0004142_abnormal_muscle_tone | 0.94995647 |
| 71 | MP0002837_dystrophic_cardiac_calcinosis | 0.93083230 |
| 72 | MP0002095_abnormal_skin_pigmentation | 0.91264333 |
| 73 | MP0005391_vision/eye_phenotype | 0.89285132 |
| 74 | MP0001764_abnormal_homeostasis | 0.86874123 |
| 75 | MP0002653_abnormal_ependyma_morphology | 0.86399814 |
| 76 | MP0003119_abnormal_digestive_system | 0.85409563 |
| 77 | MP0001188_hyperpigmentation | 0.83904845 |
| 78 | MP0003880_abnormal_central_pattern | 0.83168306 |
| 79 | MP0002277_abnormal_respiratory_mucosa | 0.80671362 |
| 80 | MP0001119_abnormal_female_reproductive | 0.79231423 |
| 81 | MP0001697_abnormal_embryo_size | 0.77945933 |
| 82 | MP0001486_abnormal_startle_reflex | 0.77694577 |
| 83 | MP0003315_abnormal_perineum_morphology | 0.76281570 |
| 84 | MP0003698_abnormal_male_reproductive | 0.74913990 |
| 85 | MP0005220_abnormal_exocrine_pancreas | 0.74333668 |
| 86 | MP0002282_abnormal_trachea_morphology | 0.72678869 |
| 87 | MP0001905_abnormal_dopamine_level | 0.71575305 |
| 88 | MP0005195_abnormal_posterior_eye | 0.71330457 |
| 89 | MP0005395_other_phenotype | 0.70275414 |
| 90 | MP0000350_abnormal_cell_proliferation | 0.70134259 |
| 91 | MP0006054_spinal_hemorrhage | 0.69409481 |
| 92 | MP0001177_atelectasis | 0.67444458 |
| 93 | MP0000647_abnormal_sebaceous_gland | 0.66665221 |
| 94 | MP0003938_abnormal_ear_development | 0.66146001 |
| 95 | MP0003122_maternal_imprinting | 0.64543617 |
| 96 | MP0002085_abnormal_embryonic_tissue | 0.63902387 |
| 97 | MP0002111_abnormal_tail_morphology | 0.63551563 |
| 98 | MP0002084_abnormal_developmental_patter | 0.62975461 |
| 99 | MP0005187_abnormal_penis_morphology | 0.61088737 |
| 100 | MP0010030_abnormal_orbit_morphology | 0.60591410 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.69662402 |
| 2 | B lymphocytopenia (HP:0010976) | 3.67648493 |
| 3 | Abnormality of the labia minora (HP:0012880) | 3.55175732 |
| 4 | Colon cancer (HP:0003003) | 3.54072720 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.44096173 |
| 6 | Acute encephalopathy (HP:0006846) | 3.37387246 |
| 7 | Abnormality of B cell number (HP:0010975) | 3.34336894 |
| 8 | Severe combined immunodeficiency (HP:0004430) | 3.33003245 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.28626620 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 3.16957353 |
| 11 | Increased CSF lactate (HP:0002490) | 3.14915622 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.14094960 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.13009074 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 2.96893496 |
| 15 | True hermaphroditism (HP:0010459) | 2.96060723 |
| 16 | Hepatic necrosis (HP:0002605) | 2.91953728 |
| 17 | Panhypogammaglobulinemia (HP:0003139) | 2.88235007 |
| 18 | Combined immunodeficiency (HP:0005387) | 2.87773834 |
| 19 | Thyroiditis (HP:0100646) | 2.85760191 |
| 20 | Molar tooth sign on MRI (HP:0002419) | 2.80154894 |
| 21 | Abnormality of midbrain morphology (HP:0002418) | 2.80154894 |
| 22 | Pancreatic cysts (HP:0001737) | 2.79916644 |
| 23 | Pancreatic fibrosis (HP:0100732) | 2.64340223 |
| 24 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.49299447 |
| 25 | Meckel diverticulum (HP:0002245) | 2.48147976 |
| 26 | Abnormal lung lobation (HP:0002101) | 2.43767935 |
| 27 | Nephronophthisis (HP:0000090) | 2.42782441 |
| 28 | Medial flaring of the eyebrow (HP:0010747) | 2.41352672 |
| 29 | Cerebral edema (HP:0002181) | 2.40627329 |
| 30 | Abnormality of the ileum (HP:0001549) | 2.39766117 |
| 31 | Methylmalonic acidemia (HP:0002912) | 2.39437169 |
| 32 | Hypoproteinemia (HP:0003075) | 2.36579498 |
| 33 | Abnormality of chromosome stability (HP:0003220) | 2.35765101 |
| 34 | Volvulus (HP:0002580) | 2.35104814 |
| 35 | Renal Fanconi syndrome (HP:0001994) | 2.32695901 |
| 36 | Septo-optic dysplasia (HP:0100842) | 2.24349990 |
| 37 | Type I transferrin isoform profile (HP:0003642) | 2.23705118 |
| 38 | 3-Methylglutaconic aciduria (HP:0003535) | 2.20803206 |
| 39 | Increased serum lactate (HP:0002151) | 2.13902870 |
| 40 | Congenital, generalized hypertrichosis (HP:0004540) | 2.10461619 |
| 41 | Abnormality of the preputium (HP:0100587) | 2.09935401 |
| 42 | Small intestinal stenosis (HP:0012848) | 2.09270506 |
| 43 | Duodenal stenosis (HP:0100867) | 2.09270506 |
| 44 | Lactic acidosis (HP:0003128) | 2.09264907 |
| 45 | Abolished electroretinogram (ERG) (HP:0000550) | 2.07557554 |
| 46 | Intestinal atresia (HP:0011100) | 2.06774784 |
| 47 | Abnormality of the duodenum (HP:0002246) | 2.03014403 |
| 48 | Aplastic anemia (HP:0001915) | 2.01143355 |
| 49 | Abnormal protein glycosylation (HP:0012346) | 2.00103066 |
| 50 | Abnormal glycosylation (HP:0012345) | 2.00103066 |
| 51 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.00103066 |
| 52 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.00103066 |
| 53 | Optic disc pallor (HP:0000543) | 1.97982791 |
| 54 | Nephrogenic diabetes insipidus (HP:0009806) | 1.96836432 |
| 55 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.96404230 |
| 56 | Exertional dyspnea (HP:0002875) | 1.94368018 |
| 57 | Abnormality of the renal medulla (HP:0100957) | 1.93776434 |
| 58 | Short tibia (HP:0005736) | 1.93545210 |
| 59 | Methylmalonic aciduria (HP:0012120) | 1.93409803 |
| 60 | Congenital primary aphakia (HP:0007707) | 1.92894502 |
| 61 | Respiratory failure (HP:0002878) | 1.90178417 |
| 62 | Supernumerary spleens (HP:0009799) | 1.90017685 |
| 63 | Chromsome breakage (HP:0040012) | 1.89509989 |
| 64 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.86775544 |
| 65 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.85934450 |
| 66 | Genital tract atresia (HP:0001827) | 1.83416644 |
| 67 | Gait imbalance (HP:0002141) | 1.83196796 |
| 68 | Optic nerve hypoplasia (HP:0000609) | 1.82866379 |
| 69 | Hypoplasia of the thymus (HP:0000778) | 1.82843074 |
| 70 | Sloping forehead (HP:0000340) | 1.82355928 |
| 71 | Hyperglycinemia (HP:0002154) | 1.81584954 |
| 72 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.79530165 |
| 73 | Hypothermia (HP:0002045) | 1.78809344 |
| 74 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.78452616 |
| 75 | Triphalangeal thumb (HP:0001199) | 1.78075064 |
| 76 | Cellular immunodeficiency (HP:0005374) | 1.76305736 |
| 77 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.75947022 |
| 78 | Myelodysplasia (HP:0002863) | 1.75876493 |
| 79 | Abnormality of methionine metabolism (HP:0010901) | 1.75855389 |
| 80 | Bile duct proliferation (HP:0001408) | 1.75048618 |
| 81 | Abnormal biliary tract physiology (HP:0012439) | 1.75048618 |
| 82 | Reduced antithrombin III activity (HP:0001976) | 1.74273833 |
| 83 | Male pseudohermaphroditism (HP:0000037) | 1.73355392 |
| 84 | Degeneration of anterior horn cells (HP:0002398) | 1.73276391 |
| 85 | Abnormality of the anterior horn cell (HP:0006802) | 1.73276391 |
| 86 | Neoplasm of the colon (HP:0100273) | 1.72925240 |
| 87 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.72263537 |
| 88 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.72230136 |
| 89 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.72230136 |
| 90 | Leukodystrophy (HP:0002415) | 1.72093940 |
| 91 | Sclerocornea (HP:0000647) | 1.71404700 |
| 92 | Renal cortical cysts (HP:0000803) | 1.71078070 |
| 93 | Median cleft lip (HP:0000161) | 1.70492863 |
| 94 | Vaginal atresia (HP:0000148) | 1.70128854 |
| 95 | Neoplasm of the adrenal gland (HP:0100631) | 1.68610781 |
| 96 | Clubbing of toes (HP:0100760) | 1.68602007 |
| 97 | Pendular nystagmus (HP:0012043) | 1.68599173 |
| 98 | Lethargy (HP:0001254) | 1.68214230 |
| 99 | Respiratory difficulties (HP:0002880) | 1.68168271 |
| 100 | Abnormality of the renal cortex (HP:0011035) | 1.67059586 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.56207304 |
| 2 | BUB1 | 3.32334056 |
| 3 | BMPR1B | 2.77972981 |
| 4 | NUAK1 | 2.68130680 |
| 5 | EIF2AK3 | 2.66978086 |
| 6 | MAP4K2 | 2.42595371 |
| 7 | VRK1 | 2.40162497 |
| 8 | SRPK1 | 2.38937183 |
| 9 | WNK3 | 2.37703429 |
| 10 | MKNK1 | 2.36500183 |
| 11 | ZAK | 2.34236663 |
| 12 | MKNK2 | 2.33069878 |
| 13 | CDC7 | 2.17314402 |
| 14 | PLK3 | 2.10106836 |
| 15 | PLK4 | 2.08374029 |
| 16 | STK16 | 2.04066074 |
| 17 | TNIK | 2.01194399 |
| 18 | TSSK6 | 1.94807389 |
| 19 | WEE1 | 1.89235869 |
| 20 | TRIM28 | 1.84667728 |
| 21 | MST4 | 1.75852297 |
| 22 | TAF1 | 1.65588319 |
| 23 | EIF2AK1 | 1.62757710 |
| 24 | TTK | 1.57775012 |
| 25 | FRK | 1.56008985 |
| 26 | INSRR | 1.54579936 |
| 27 | BRSK2 | 1.51561163 |
| 28 | NEK1 | 1.47446029 |
| 29 | BCKDK | 1.45854198 |
| 30 | TGFBR1 | 1.39869568 |
| 31 | DYRK2 | 1.34121593 |
| 32 | PBK | 1.32210617 |
| 33 | PASK | 1.32132369 |
| 34 | CSNK1G1 | 1.17065166 |
| 35 | PLK2 | 1.16314068 |
| 36 | PLK1 | 1.16085228 |
| 37 | STK38L | 1.07380571 |
| 38 | CSNK1G3 | 1.05574351 |
| 39 | MAPK13 | 1.05194262 |
| 40 | ADRBK2 | 1.04423642 |
| 41 | MAP3K4 | 1.02460732 |
| 42 | PNCK | 1.02006982 |
| 43 | NME1 | 1.00916356 |
| 44 | CSNK1G2 | 0.98764421 |
| 45 | CDK8 | 0.97885430 |
| 46 | BCR | 0.96414075 |
| 47 | RPS6KA4 | 0.95191384 |
| 48 | EIF2AK2 | 0.93680013 |
| 49 | MAP2K7 | 0.93550175 |
| 50 | ERBB3 | 0.90695519 |
| 51 | TIE1 | 0.90658967 |
| 52 | CDK19 | 0.89657088 |
| 53 | ATR | 0.88821140 |
| 54 | CASK | 0.87934258 |
| 55 | NLK | 0.87747180 |
| 56 | PINK1 | 0.87361272 |
| 57 | TEC | 0.84204363 |
| 58 | GRK1 | 0.82798775 |
| 59 | CCNB1 | 0.77438981 |
| 60 | DYRK3 | 0.74675157 |
| 61 | STK3 | 0.74364926 |
| 62 | CSNK1A1L | 0.70109651 |
| 63 | KIT | 0.67452108 |
| 64 | OXSR1 | 0.67245379 |
| 65 | ACVR1B | 0.66655464 |
| 66 | AURKB | 0.66269986 |
| 67 | DAPK1 | 0.65149195 |
| 68 | NEK2 | 0.64122205 |
| 69 | ATM | 0.64006475 |
| 70 | FLT3 | 0.63231813 |
| 71 | CHEK2 | 0.58545950 |
| 72 | CDK3 | 0.56044897 |
| 73 | TAOK3 | 0.55412189 |
| 74 | PRKCE | 0.50848589 |
| 75 | PRKCG | 0.50444090 |
| 76 | RPS6KA5 | 0.49463083 |
| 77 | CSNK2A1 | 0.47165004 |
| 78 | KDR | 0.44649720 |
| 79 | CLK1 | 0.44271817 |
| 80 | TLK1 | 0.40968134 |
| 81 | CSNK2A2 | 0.40821432 |
| 82 | BRSK1 | 0.40548214 |
| 83 | TXK | 0.37346115 |
| 84 | BRD4 | 0.37233978 |
| 85 | CDK7 | 0.34776706 |
| 86 | STK4 | 0.34284144 |
| 87 | MAPKAPK5 | 0.34259847 |
| 88 | IRAK1 | 0.33972295 |
| 89 | CDK9 | 0.33553918 |
| 90 | CHEK1 | 0.33461164 |
| 91 | MINK1 | 0.32531852 |
| 92 | CSNK1A1 | 0.31816999 |
| 93 | FGFR2 | 0.29480110 |
| 94 | MAP3K12 | 0.29221444 |
| 95 | OBSCN | 0.28650218 |
| 96 | PKN1 | 0.26358715 |
| 97 | CSNK1E | 0.25506027 |
| 98 | DYRK1A | 0.24912137 |
| 99 | STK39 | 0.23763843 |
| 100 | MAPKAPK3 | 0.23500781 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.90968297 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.44476578 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.23691165 |
| 4 | Non-homologous end-joining_Homo sapiens_hsa03450 | 3.09614870 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 3.08591263 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.01610497 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.78996834 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.75848321 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.62256682 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.52039979 |
| 11 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.38547447 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 2.30899999 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 2.21737794 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 2.20184250 |
| 15 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.01263995 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 2.00420496 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.96421919 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.92614517 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.92135964 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.87178293 |
| 21 | Huntingtons disease_Homo sapiens_hsa05016 | 1.70167578 |
| 22 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.69018329 |
| 23 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.59801387 |
| 24 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.50774807 |
| 25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.47811839 |
| 26 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.47602144 |
| 27 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.45354481 |
| 28 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.42714755 |
| 29 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.42495951 |
| 30 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.42427684 |
| 31 | Cell cycle_Homo sapiens_hsa04110 | 1.37994969 |
| 32 | Purine metabolism_Homo sapiens_hsa00230 | 1.37391110 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.36788502 |
| 34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.26419353 |
| 35 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.23999305 |
| 36 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.13757212 |
| 37 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.09837509 |
| 38 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.08753203 |
| 39 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.01724760 |
| 40 | Phototransduction_Homo sapiens_hsa04744 | 1.01110728 |
| 41 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.99083979 |
| 42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.93503562 |
| 43 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.90234861 |
| 44 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.89996557 |
| 45 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.87983565 |
| 46 | Peroxisome_Homo sapiens_hsa04146 | 0.87348143 |
| 47 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.82886781 |
| 48 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.82167407 |
| 49 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.80849274 |
| 50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.79108200 |
| 51 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.76393412 |
| 52 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.75782989 |
| 53 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.73800062 |
| 54 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.71361668 |
| 55 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.69762966 |
| 56 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.67913610 |
| 57 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.67862547 |
| 58 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67391257 |
| 59 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.61720075 |
| 60 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.61194161 |
| 61 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.60992807 |
| 62 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.57589319 |
| 63 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.55188275 |
| 64 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.54866689 |
| 65 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52685152 |
| 66 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.51354141 |
| 67 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.50797473 |
| 68 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47771540 |
| 69 | Olfactory transduction_Homo sapiens_hsa04740 | 0.46561661 |
| 70 | Nicotine addiction_Homo sapiens_hsa05033 | 0.45255159 |
| 71 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.44825439 |
| 72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.44062219 |
| 73 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.43875978 |
| 74 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.43704270 |
| 75 | Carbon metabolism_Homo sapiens_hsa01200 | 0.43357560 |
| 76 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.43328039 |
| 77 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.42352786 |
| 78 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.41980654 |
| 79 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.40656372 |
| 80 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.39703166 |
| 81 | Asthma_Homo sapiens_hsa05310 | 0.38330959 |
| 82 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37017923 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36826345 |
| 84 | Taste transduction_Homo sapiens_hsa04742 | 0.36696549 |
| 85 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.36455451 |
| 86 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.35685481 |
| 87 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.35279397 |
| 88 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.31786303 |
| 89 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.31706574 |
| 90 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.31584281 |
| 91 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.30406160 |
| 92 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.29402573 |
| 93 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.28912904 |
| 94 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.27131191 |
| 95 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.26632324 |
| 96 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.26199391 |
| 97 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.24386821 |
| 98 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.22341805 |
| 99 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.21678448 |
| 100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.19407465 |

