ZNF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.79837766
2chromatin remodeling at centromere (GO:0031055)4.48768292
3CENP-A containing nucleosome assembly (GO:0034080)4.44141311
4proteasome assembly (GO:0043248)4.35026365
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26323384
6protein complex biogenesis (GO:0070271)3.87491224
7mitochondrial respiratory chain complex assembly (GO:0033108)3.81444807
8histone exchange (GO:0043486)3.77987614
9establishment of integrated proviral latency (GO:0075713)3.76814658
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.73599294
11cullin deneddylation (GO:0010388)3.68480214
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.67910042
13NADH dehydrogenase complex assembly (GO:0010257)3.67910042
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67910042
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66858784
16DNA ligation (GO:0006266)3.64751635
17protein neddylation (GO:0045116)3.64623359
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63362885
19DNA catabolic process, exonucleolytic (GO:0000738)3.63107356
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61870785
21respiratory chain complex IV assembly (GO:0008535)3.61365767
22ATP synthesis coupled proton transport (GO:0015986)3.61305976
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.61305976
24kinetochore organization (GO:0051383)3.52969038
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.51652718
26replication fork processing (GO:0031297)3.49403057
27kinetochore assembly (GO:0051382)3.49343451
28DNA damage response, detection of DNA damage (GO:0042769)3.48962191
29DNA replication-independent nucleosome organization (GO:0034724)3.46794504
30DNA replication-independent nucleosome assembly (GO:0006336)3.46794504
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45557552
32resolution of meiotic recombination intermediates (GO:0000712)3.37452173
33cytochrome complex assembly (GO:0017004)3.32357528
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30167003
35protein deneddylation (GO:0000338)3.29131994
36purine nucleobase biosynthetic process (GO:0009113)3.26600329
37maturation of 5.8S rRNA (GO:0000460)3.26428869
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23545262
39negative regulation of ligase activity (GO:0051352)3.23545262
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22273224
41telomere maintenance via semi-conservative replication (GO:0032201)3.19501862
42rRNA modification (GO:0000154)3.18503644
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17197195
44regulation of mitotic spindle checkpoint (GO:1903504)3.17197195
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16969336
46regulation of helicase activity (GO:0051095)3.16936008
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15172952
48DNA strand elongation involved in DNA replication (GO:0006271)3.14955120
49mitotic recombination (GO:0006312)3.11244659
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08670689
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08670689
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.07465435
53termination of RNA polymerase III transcription (GO:0006386)3.07465435
54chaperone-mediated protein transport (GO:0072321)3.06380773
55V(D)J recombination (GO:0033151)3.06333517
56protein K6-linked ubiquitination (GO:0085020)3.05859151
57mismatch repair (GO:0006298)3.05638151
58regulation of mitochondrial translation (GO:0070129)3.04448367
59histone mRNA metabolic process (GO:0008334)3.04023433
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01234582
61DNA replication-dependent nucleosome assembly (GO:0006335)3.00537115
62DNA replication-dependent nucleosome organization (GO:0034723)3.00537115
63spliceosomal snRNP assembly (GO:0000387)3.00424971
64DNA strand elongation (GO:0022616)2.98722965
65telomere maintenance via recombination (GO:0000722)2.92991430
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90272049
67pseudouridine synthesis (GO:0001522)2.90169101
68somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89783158
69somatic hypermutation of immunoglobulin genes (GO:0016446)2.89783158
70DNA deamination (GO:0045006)2.89149840
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88355554
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88355554
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88355554
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87722204
75DNA topological change (GO:0006265)2.87630168
76DNA replication checkpoint (GO:0000076)2.86672300
77regulation of cellular amino acid metabolic process (GO:0006521)2.85670989
78histone H2A acetylation (GO:0043968)2.85506147
79establishment of viral latency (GO:0019043)2.85292286
80nucleobase biosynthetic process (GO:0046112)2.84675736
81water-soluble vitamin biosynthetic process (GO:0042364)2.84627121
82deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.84624487
83recombinational repair (GO:0000725)2.84290686
84oxidative phosphorylation (GO:0006119)2.84266731
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82562044
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82562044
87negative regulation of thymocyte apoptotic process (GO:0070244)2.82105093
88postreplication repair (GO:0006301)2.81320823
89respiratory electron transport chain (GO:0022904)2.80462782
90double-strand break repair via homologous recombination (GO:0000724)2.80019611
91electron transport chain (GO:0022900)2.77678185
92negative regulation of DNA recombination (GO:0045910)2.77666196
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75525601
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75525601
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75525601
96negative regulation of mitotic sister chromatid separation (GO:2000816)2.75525601
97negative regulation of sister chromatid segregation (GO:0033046)2.75525601
98DNA integration (GO:0015074)2.74356507
99somatic diversification of immune receptors (GO:0002200)2.74207124
100positive regulation of ligase activity (GO:0051351)2.74116148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52788157
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.02202228
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.84448426
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.70010147
5E2F7_22180533_ChIP-Seq_HELA_Human3.56337565
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30223645
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.06311588
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84656103
9ELK1_19687146_ChIP-ChIP_HELA_Human2.79639592
10ZNF274_21170338_ChIP-Seq_K562_Hela2.67077286
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65188087
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46590514
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46251304
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40459293
15VDR_23849224_ChIP-Seq_CD4+_Human2.33247903
16EWS_26573619_Chip-Seq_HEK293_Human2.31870722
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.25112828
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24927188
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.20521514
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.16542918
21FUS_26573619_Chip-Seq_HEK293_Human2.14630335
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09232906
23FOXP3_21729870_ChIP-Seq_TREG_Human2.06706965
24IGF1R_20145208_ChIP-Seq_DFB_Human2.00216669
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98274835
26MYC_18940864_ChIP-ChIP_HL60_Human1.92693752
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86447009
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81600038
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.79240392
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77242204
31VDR_22108803_ChIP-Seq_LS180_Human1.74772014
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73492113
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.72700480
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67126445
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56997819
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56255998
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55895365
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.54843892
39TAF15_26573619_Chip-Seq_HEK293_Human1.54801042
40P300_19829295_ChIP-Seq_ESCs_Human1.54704309
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53223420
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48345601
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47586514
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47246340
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41808628
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41435427
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.39711036
48TTF2_22483619_ChIP-Seq_HELA_Human1.37966258
49DCP1A_22483619_ChIP-Seq_HELA_Human1.34020476
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33541577
51GBX2_23144817_ChIP-Seq_PC3_Human1.33074747
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.32223548
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30712367
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30239686
55IRF1_19129219_ChIP-ChIP_H3396_Human1.29570441
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29174870
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28248754
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24736545
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23504205
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23452658
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.21865913
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21672876
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21618881
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.21522998
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20750456
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19863459
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.18933758
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15983290
69GABP_19822575_ChIP-Seq_HepG2_Human1.15776521
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14781848
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14238422
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12077233
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10895713
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07130264
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05879978
76TP53_22573176_ChIP-Seq_HFKS_Human1.03643744
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02698082
78NANOG_19829295_ChIP-Seq_ESCs_Human1.00515564
79SOX2_19829295_ChIP-Seq_ESCs_Human1.00515564
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00224263
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.99807332
82MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99432352
83ER_23166858_ChIP-Seq_MCF-7_Human0.96691891
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.96506289
85CBP_20019798_ChIP-Seq_JUKART_Human0.96081032
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96081032
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96005894
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95153662
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94191911
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92586599
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89349002
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88890945
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.88631837
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85285232
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85078472
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.85078472
97* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83264495
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82861434
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82745796
100SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81855286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.74672090
2MP0010094_abnormal_chromosome_stability3.71782796
3MP0008877_abnormal_DNA_methylation3.43869446
4MP0006292_abnormal_olfactory_placode3.26563693
5MP0003718_maternal_effect2.52663750
6MP0008789_abnormal_olfactory_epithelium2.49555720
7MP0002102_abnormal_ear_morphology2.47147831
8MP0003693_abnormal_embryo_hatching2.43369118
9MP0006072_abnormal_retinal_apoptosis2.39741711
10MP0004957_abnormal_blastocyst_morpholog2.23559216
11MP0009697_abnormal_copulation2.22210866
12MP0001529_abnormal_vocalization2.13418181
13MP0005084_abnormal_gallbladder_morpholo2.06875357
14MP0003111_abnormal_nucleus_morphology2.02404451
15MP0001293_anophthalmia2.01038008
16MP0002736_abnormal_nociception_after1.95650800
17MP0005499_abnormal_olfactory_system1.90286569
18MP0005394_taste/olfaction_phenotype1.90286569
19MP0008007_abnormal_cellular_replicative1.86983523
20MP0003077_abnormal_cell_cycle1.85192569
21MP0004147_increased_porphyrin_level1.78413859
22MP0008932_abnormal_embryonic_tissue1.78384893
23MP0003787_abnormal_imprinting1.76884482
24MP0003567_abnormal_fetal_cardiomyocyte1.72440289
25MP0002938_white_spotting1.69076561
26MP0008057_abnormal_DNA_replication1.60538294
27MP0000372_irregular_coat_pigmentation1.53244502
28MP0002234_abnormal_pharynx_morphology1.52234556
29MP0003136_yellow_coat_color1.51558220
30MP0003121_genomic_imprinting1.50557981
31MP0005253_abnormal_eye_physiology1.49308129
32MP0006036_abnormal_mitochondrial_physio1.48334499
33MP0003011_delayed_dark_adaptation1.45718681
34MP0001968_abnormal_touch/_nociception1.42808597
35MP0003786_premature_aging1.41929643
36MP0008995_early_reproductive_senescence1.41360744
37MP0005075_abnormal_melanosome_morpholog1.40543442
38MP0003195_calcinosis1.36279051
39MP0002751_abnormal_autonomic_nervous1.33681838
40MP0001984_abnormal_olfaction1.32823991
41MP0000516_abnormal_urinary_system1.31490989
42MP0005367_renal/urinary_system_phenotyp1.31490989
43MP0002132_abnormal_respiratory_system1.29742413
44MP0003890_abnormal_embryonic-extraembry1.27385119
45MP0000631_abnormal_neuroendocrine_gland1.26927294
46MP0003186_abnormal_redox_activity1.25101552
47MP0003283_abnormal_digestive_organ1.22140127
48MP0002138_abnormal_hepatobiliary_system1.21248922
49MP0006276_abnormal_autonomic_nervous1.20953355
50MP0001485_abnormal_pinna_reflex1.20229781
51MP0005646_abnormal_pituitary_gland1.17571735
52MP0003806_abnormal_nucleotide_metabolis1.14745547
53MP0002233_abnormal_nose_morphology1.13913004
54MP0004885_abnormal_endolymph1.13014537
55MP0004133_heterotaxia1.12824402
56MP0002638_abnormal_pupillary_reflex1.12609763
57MP0008872_abnormal_physiological_respon1.12415017
58MP0000049_abnormal_middle_ear1.11630757
59MP0005551_abnormal_eye_electrophysiolog1.11615965
60MP0005645_abnormal_hypothalamus_physiol1.10152882
61MP0006035_abnormal_mitochondrial_morpho1.08852406
62MP0001929_abnormal_gametogenesis1.08713028
63MP0001286_abnormal_eye_development1.03332569
64MP0002210_abnormal_sex_determination1.01359008
65MP0003937_abnormal_limbs/digits/tail_de0.98955956
66MP0000653_abnormal_sex_gland0.98522365
67MP0004215_abnormal_myocardial_fiber0.97652812
68MP0002396_abnormal_hematopoietic_system0.97187498
69MP0001145_abnormal_male_reproductive0.95226143
70MP0004142_abnormal_muscle_tone0.94995647
71MP0002837_dystrophic_cardiac_calcinosis0.93083230
72MP0002095_abnormal_skin_pigmentation0.91264333
73MP0005391_vision/eye_phenotype0.89285132
74MP0001764_abnormal_homeostasis0.86874123
75MP0002653_abnormal_ependyma_morphology0.86399814
76MP0003119_abnormal_digestive_system0.85409563
77MP0001188_hyperpigmentation0.83904845
78MP0003880_abnormal_central_pattern0.83168306
79MP0002277_abnormal_respiratory_mucosa0.80671362
80MP0001119_abnormal_female_reproductive0.79231423
81MP0001697_abnormal_embryo_size0.77945933
82MP0001486_abnormal_startle_reflex0.77694577
83MP0003315_abnormal_perineum_morphology0.76281570
84MP0003698_abnormal_male_reproductive0.74913990
85MP0005220_abnormal_exocrine_pancreas0.74333668
86MP0002282_abnormal_trachea_morphology0.72678869
87MP0001905_abnormal_dopamine_level0.71575305
88MP0005195_abnormal_posterior_eye0.71330457
89MP0005395_other_phenotype0.70275414
90MP0000350_abnormal_cell_proliferation0.70134259
91MP0006054_spinal_hemorrhage0.69409481
92MP0001177_atelectasis0.67444458
93MP0000647_abnormal_sebaceous_gland0.66665221
94MP0003938_abnormal_ear_development0.66146001
95MP0003122_maternal_imprinting0.64543617
96MP0002085_abnormal_embryonic_tissue0.63902387
97MP0002111_abnormal_tail_morphology0.63551563
98MP0002084_abnormal_developmental_patter0.62975461
99MP0005187_abnormal_penis_morphology0.61088737
100MP0010030_abnormal_orbit_morphology0.60591410

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.69662402
2B lymphocytopenia (HP:0010976)3.67648493
3Abnormality of the labia minora (HP:0012880)3.55175732
4Colon cancer (HP:0003003)3.54072720
5Mitochondrial inheritance (HP:0001427)3.44096173
6Acute encephalopathy (HP:0006846)3.37387246
7Abnormality of B cell number (HP:0010975)3.34336894
8Severe combined immunodeficiency (HP:0004430)3.33003245
9Progressive macrocephaly (HP:0004481)3.28626620
10Increased hepatocellular lipid droplets (HP:0006565)3.16957353
11Increased CSF lactate (HP:0002490)3.14915622
12Abnormal mitochondria in muscle tissue (HP:0008316)3.14094960
13Hepatocellular necrosis (HP:0001404)3.13009074
14Lipid accumulation in hepatocytes (HP:0006561)2.96893496
15True hermaphroditism (HP:0010459)2.96060723
16Hepatic necrosis (HP:0002605)2.91953728
17Panhypogammaglobulinemia (HP:0003139)2.88235007
18Combined immunodeficiency (HP:0005387)2.87773834
19Thyroiditis (HP:0100646)2.85760191
20Molar tooth sign on MRI (HP:0002419)2.80154894
21Abnormality of midbrain morphology (HP:0002418)2.80154894
22Pancreatic cysts (HP:0001737)2.79916644
23Pancreatic fibrosis (HP:0100732)2.64340223
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.49299447
25Meckel diverticulum (HP:0002245)2.48147976
26Abnormal lung lobation (HP:0002101)2.43767935
27Nephronophthisis (HP:0000090)2.42782441
28Medial flaring of the eyebrow (HP:0010747)2.41352672
29Cerebral edema (HP:0002181)2.40627329
30Abnormality of the ileum (HP:0001549)2.39766117
31Methylmalonic acidemia (HP:0002912)2.39437169
32Hypoproteinemia (HP:0003075)2.36579498
33Abnormality of chromosome stability (HP:0003220)2.35765101
34Volvulus (HP:0002580)2.35104814
35Renal Fanconi syndrome (HP:0001994)2.32695901
36Septo-optic dysplasia (HP:0100842)2.24349990
37Type I transferrin isoform profile (HP:0003642)2.23705118
383-Methylglutaconic aciduria (HP:0003535)2.20803206
39Increased serum lactate (HP:0002151)2.13902870
40Congenital, generalized hypertrichosis (HP:0004540)2.10461619
41Abnormality of the preputium (HP:0100587)2.09935401
42Small intestinal stenosis (HP:0012848)2.09270506
43Duodenal stenosis (HP:0100867)2.09270506
44Lactic acidosis (HP:0003128)2.09264907
45Abolished electroretinogram (ERG) (HP:0000550)2.07557554
46Intestinal atresia (HP:0011100)2.06774784
47Abnormality of the duodenum (HP:0002246)2.03014403
48Aplastic anemia (HP:0001915)2.01143355
49Abnormal protein glycosylation (HP:0012346)2.00103066
50Abnormal glycosylation (HP:0012345)2.00103066
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00103066
52Abnormal protein N-linked glycosylation (HP:0012347)2.00103066
53Optic disc pallor (HP:0000543)1.97982791
54Nephrogenic diabetes insipidus (HP:0009806)1.96836432
55Pancreatic islet-cell hyperplasia (HP:0004510)1.96404230
56Exertional dyspnea (HP:0002875)1.94368018
57Abnormality of the renal medulla (HP:0100957)1.93776434
58Short tibia (HP:0005736)1.93545210
59Methylmalonic aciduria (HP:0012120)1.93409803
60Congenital primary aphakia (HP:0007707)1.92894502
61Respiratory failure (HP:0002878)1.90178417
62Supernumerary spleens (HP:0009799)1.90017685
63Chromsome breakage (HP:0040012)1.89509989
64Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86775544
65Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85934450
66Genital tract atresia (HP:0001827)1.83416644
67Gait imbalance (HP:0002141)1.83196796
68Optic nerve hypoplasia (HP:0000609)1.82866379
69Hypoplasia of the thymus (HP:0000778)1.82843074
70Sloping forehead (HP:0000340)1.82355928
71Hyperglycinemia (HP:0002154)1.81584954
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.79530165
73Hypothermia (HP:0002045)1.78809344
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78452616
75Triphalangeal thumb (HP:0001199)1.78075064
76Cellular immunodeficiency (HP:0005374)1.76305736
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.75947022
78Myelodysplasia (HP:0002863)1.75876493
79Abnormality of methionine metabolism (HP:0010901)1.75855389
80Bile duct proliferation (HP:0001408)1.75048618
81Abnormal biliary tract physiology (HP:0012439)1.75048618
82Reduced antithrombin III activity (HP:0001976)1.74273833
83Male pseudohermaphroditism (HP:0000037)1.73355392
84Degeneration of anterior horn cells (HP:0002398)1.73276391
85Abnormality of the anterior horn cell (HP:0006802)1.73276391
86Neoplasm of the colon (HP:0100273)1.72925240
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72263537
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72230136
89Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72230136
90Leukodystrophy (HP:0002415)1.72093940
91Sclerocornea (HP:0000647)1.71404700
92Renal cortical cysts (HP:0000803)1.71078070
93Median cleft lip (HP:0000161)1.70492863
94Vaginal atresia (HP:0000148)1.70128854
95Neoplasm of the adrenal gland (HP:0100631)1.68610781
96Clubbing of toes (HP:0100760)1.68602007
97Pendular nystagmus (HP:0012043)1.68599173
98Lethargy (HP:0001254)1.68214230
99Respiratory difficulties (HP:0002880)1.68168271
100Abnormality of the renal cortex (HP:0011035)1.67059586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.56207304
2BUB13.32334056
3BMPR1B2.77972981
4NUAK12.68130680
5EIF2AK32.66978086
6MAP4K22.42595371
7VRK12.40162497
8SRPK12.38937183
9WNK32.37703429
10MKNK12.36500183
11ZAK2.34236663
12MKNK22.33069878
13CDC72.17314402
14PLK32.10106836
15PLK42.08374029
16STK162.04066074
17TNIK2.01194399
18TSSK61.94807389
19WEE11.89235869
20TRIM281.84667728
21MST41.75852297
22TAF11.65588319
23EIF2AK11.62757710
24TTK1.57775012
25FRK1.56008985
26INSRR1.54579936
27BRSK21.51561163
28NEK11.47446029
29BCKDK1.45854198
30TGFBR11.39869568
31DYRK21.34121593
32PBK1.32210617
33PASK1.32132369
34CSNK1G11.17065166
35PLK21.16314068
36PLK11.16085228
37STK38L1.07380571
38CSNK1G31.05574351
39MAPK131.05194262
40ADRBK21.04423642
41MAP3K41.02460732
42PNCK1.02006982
43NME11.00916356
44CSNK1G20.98764421
45CDK80.97885430
46BCR0.96414075
47RPS6KA40.95191384
48EIF2AK20.93680013
49MAP2K70.93550175
50ERBB30.90695519
51TIE10.90658967
52CDK190.89657088
53ATR0.88821140
54CASK0.87934258
55NLK0.87747180
56PINK10.87361272
57TEC0.84204363
58GRK10.82798775
59CCNB10.77438981
60DYRK30.74675157
61STK30.74364926
62CSNK1A1L0.70109651
63KIT0.67452108
64OXSR10.67245379
65ACVR1B0.66655464
66AURKB0.66269986
67DAPK10.65149195
68NEK20.64122205
69ATM0.64006475
70FLT30.63231813
71CHEK20.58545950
72CDK30.56044897
73TAOK30.55412189
74PRKCE0.50848589
75PRKCG0.50444090
76RPS6KA50.49463083
77CSNK2A10.47165004
78KDR0.44649720
79CLK10.44271817
80TLK10.40968134
81CSNK2A20.40821432
82BRSK10.40548214
83TXK0.37346115
84BRD40.37233978
85CDK70.34776706
86STK40.34284144
87MAPKAPK50.34259847
88IRAK10.33972295
89CDK90.33553918
90CHEK10.33461164
91MINK10.32531852
92CSNK1A10.31816999
93FGFR20.29480110
94MAP3K120.29221444
95OBSCN0.28650218
96PKN10.26358715
97CSNK1E0.25506027
98DYRK1A0.24912137
99STK390.23763843
100MAPKAPK30.23500781

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.90968297
2Mismatch repair_Homo sapiens_hsa034303.44476578
3Protein export_Homo sapiens_hsa030603.23691165
4Non-homologous end-joining_Homo sapiens_hsa034503.09614870
5DNA replication_Homo sapiens_hsa030303.08591263
6Homologous recombination_Homo sapiens_hsa034403.01610497
7Oxidative phosphorylation_Homo sapiens_hsa001902.78996834
8RNA polymerase_Homo sapiens_hsa030202.75848321
9Parkinsons disease_Homo sapiens_hsa050122.62256682
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52039979
11Fanconi anemia pathway_Homo sapiens_hsa034602.38547447
12Ribosome_Homo sapiens_hsa030102.30899999
13Base excision repair_Homo sapiens_hsa034102.21737794
14Spliceosome_Homo sapiens_hsa030402.20184250
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01263995
16RNA degradation_Homo sapiens_hsa030182.00420496
17Basal transcription factors_Homo sapiens_hsa030221.96421919
18Nucleotide excision repair_Homo sapiens_hsa034201.92614517
19Propanoate metabolism_Homo sapiens_hsa006401.92135964
20RNA transport_Homo sapiens_hsa030131.87178293
21Huntingtons disease_Homo sapiens_hsa050161.70167578
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69018329
23Pyrimidine metabolism_Homo sapiens_hsa002401.59801387
24Butanoate metabolism_Homo sapiens_hsa006501.50774807
25Alzheimers disease_Homo sapiens_hsa050101.47811839
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47602144
27One carbon pool by folate_Homo sapiens_hsa006701.45354481
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42714755
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42495951
30Fatty acid elongation_Homo sapiens_hsa000621.42427684
31Cell cycle_Homo sapiens_hsa041101.37994969
32Purine metabolism_Homo sapiens_hsa002301.37391110
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36788502
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.26419353
35Selenocompound metabolism_Homo sapiens_hsa004501.23999305
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13757212
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09837509
38Primary immunodeficiency_Homo sapiens_hsa053401.08753203
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.01724760
40Phototransduction_Homo sapiens_hsa047441.01110728
41Caffeine metabolism_Homo sapiens_hsa002320.99083979
42Pyruvate metabolism_Homo sapiens_hsa006200.93503562
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90234861
44Nitrogen metabolism_Homo sapiens_hsa009100.89996557
45Steroid biosynthesis_Homo sapiens_hsa001000.87983565
46Peroxisome_Homo sapiens_hsa041460.87348143
47Folate biosynthesis_Homo sapiens_hsa007900.82886781
48mRNA surveillance pathway_Homo sapiens_hsa030150.82167407
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80849274
50Glutathione metabolism_Homo sapiens_hsa004800.79108200
51Cardiac muscle contraction_Homo sapiens_hsa042600.76393412
52Oocyte meiosis_Homo sapiens_hsa041140.75782989
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73800062
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71361668
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69762966
56p53 signaling pathway_Homo sapiens_hsa041150.67913610
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67862547
58Metabolic pathways_Homo sapiens_hsa011000.67391257
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61720075
60Linoleic acid metabolism_Homo sapiens_hsa005910.61194161
61Regulation of autophagy_Homo sapiens_hsa041400.60992807
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57589319
63Tryptophan metabolism_Homo sapiens_hsa003800.55188275
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54866689
65Fatty acid metabolism_Homo sapiens_hsa012120.52685152
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51354141
67Ether lipid metabolism_Homo sapiens_hsa005650.50797473
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47771540
69Olfactory transduction_Homo sapiens_hsa047400.46561661
70Nicotine addiction_Homo sapiens_hsa050330.45255159
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44825439
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44062219
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43875978
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43704270
75Carbon metabolism_Homo sapiens_hsa012000.43357560
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.43328039
77beta-Alanine metabolism_Homo sapiens_hsa004100.42352786
78Chemical carcinogenesis_Homo sapiens_hsa052040.41980654
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40656372
80Fatty acid degradation_Homo sapiens_hsa000710.39703166
81Asthma_Homo sapiens_hsa053100.38330959
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37017923
83Retinol metabolism_Homo sapiens_hsa008300.36826345
84Taste transduction_Homo sapiens_hsa047420.36696549
85Sulfur metabolism_Homo sapiens_hsa009200.36455451
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35685481
87Arachidonic acid metabolism_Homo sapiens_hsa005900.35279397
88Biosynthesis of amino acids_Homo sapiens_hsa012300.31786303
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31706574
90Type I diabetes mellitus_Homo sapiens_hsa049400.31584281
91Systemic lupus erythematosus_Homo sapiens_hsa053220.30406160
92Basal cell carcinoma_Homo sapiens_hsa052170.29402573
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28912904
94TGF-beta signaling pathway_Homo sapiens_hsa043500.27131191
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.26632324
96Epstein-Barr virus infection_Homo sapiens_hsa051690.26199391
97Hedgehog signaling pathway_Homo sapiens_hsa043400.24386821
98Collecting duct acid secretion_Homo sapiens_hsa049660.22341805
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21678448
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19407465

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