ZNF222

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)5.18944637
2translesion synthesis (GO:0019985)4.59010700
3cullin deneddylation (GO:0010388)4.55813886
4retinal cone cell development (GO:0046549)4.49933522
5cell wall macromolecule metabolic process (GO:0044036)4.42633074
6protein deneddylation (GO:0000338)4.39579137
7regulation of DNA methylation (GO:0044030)4.32867064
8regulation of mitotic spindle checkpoint (GO:1903504)4.19663608
9regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.19663608
10transcription from mitochondrial promoter (GO:0006390)4.10504190
11negative regulation of translation, ncRNA-mediated (GO:0040033)3.90589550
12regulation of translation, ncRNA-mediated (GO:0045974)3.90589550
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.90589550
14proline transport (GO:0015824)3.88313218
15postreplication repair (GO:0006301)3.87797091
16neural tube formation (GO:0001841)3.74522793
17regulation of meiosis I (GO:0060631)3.61614018
18piRNA metabolic process (GO:0034587)3.57490765
19presynaptic membrane assembly (GO:0097105)3.52651783
20replication fork processing (GO:0031297)3.39666387
21intraciliary transport (GO:0042073)3.27923541
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.24685623
23DNA double-strand break processing (GO:0000729)3.24411978
24acrosome reaction (GO:0007340)3.23988955
25chromatin remodeling at centromere (GO:0031055)3.20466864
26meiotic cell cycle (GO:0051321)3.19188896
27nonmotile primary cilium assembly (GO:0035058)3.18215733
28protein-cofactor linkage (GO:0018065)3.15742267
29rRNA methylation (GO:0031167)3.09812049
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09524818
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09524818
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.09524818
33ubiquinone biosynthetic process (GO:0006744)3.07076296
34inositol phosphate catabolic process (GO:0071545)3.05858289
35mitochondrial RNA metabolic process (GO:0000959)3.05411060
36rRNA modification (GO:0000154)3.04081308
37protein localization to cilium (GO:0061512)3.02356398
38multicellular organism reproduction (GO:0032504)2.99840281
39regulation of development, heterochronic (GO:0040034)2.99203849
40kinetochore assembly (GO:0051382)2.99093811
41phosphorylated carbohydrate dephosphorylation (GO:0046838)2.98304261
42inositol phosphate dephosphorylation (GO:0046855)2.98304261
43mitochondrial respiratory chain complex I assembly (GO:0032981)2.98031036
44NADH dehydrogenase complex assembly (GO:0010257)2.98031036
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98031036
46cAMP catabolic process (GO:0006198)2.97583132
47ubiquinone metabolic process (GO:0006743)2.97251365
48cellular ketone body metabolic process (GO:0046950)2.93754115
49protein heterotetramerization (GO:0051290)2.93101095
50CENP-A containing nucleosome assembly (GO:0034080)2.92246954
51aggressive behavior (GO:0002118)2.90773661
52myelin assembly (GO:0032288)2.89335684
53positive regulation of gastrulation (GO:2000543)2.89115173
54presynaptic membrane organization (GO:0097090)2.88911999
55regulation of timing of cell differentiation (GO:0048505)2.86564135
56resolution of meiotic recombination intermediates (GO:0000712)2.86372507
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.84750935
58cilium morphogenesis (GO:0060271)2.81168513
59nucleotide-excision repair, DNA gap filling (GO:0006297)2.79819039
60centriole replication (GO:0007099)2.79243839
61cyclic nucleotide catabolic process (GO:0009214)2.78260945
62protein complex biogenesis (GO:0070271)2.78154283
63sperm-egg recognition (GO:0035036)2.78110416
64proteasome assembly (GO:0043248)2.77273995
65protein targeting to Golgi (GO:0000042)2.76878369
66positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.75819073
67mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.75819073
68photoreceptor cell maintenance (GO:0045494)2.75772578
69alanine transport (GO:0032328)2.75136126
70synapsis (GO:0007129)2.72925671
71platelet dense granule organization (GO:0060155)2.72903210
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72624361
73base-excision repair, AP site formation (GO:0006285)2.70943558
74establishment of protein localization to Golgi (GO:0072600)2.70613882
75DNA methylation involved in gamete generation (GO:0043046)2.69419695
76protein K11-linked deubiquitination (GO:0035871)2.69222683
77reciprocal DNA recombination (GO:0035825)2.68075001
78reciprocal meiotic recombination (GO:0007131)2.68075001
79mitochondrial respiratory chain complex assembly (GO:0033108)2.67963220
80establishment of melanosome localization (GO:0032401)2.63559395
81DNA replication-dependent nucleosome assembly (GO:0006335)2.62531963
82DNA replication-dependent nucleosome organization (GO:0034723)2.62531963
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62516855
84ketone body metabolic process (GO:1902224)2.62253947
85regulation of female gonad development (GO:2000194)2.61159229
86gene silencing by RNA (GO:0031047)2.60622696
87histone exchange (GO:0043486)2.59130502
88protein polyglutamylation (GO:0018095)2.58846512
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56613521
90positive regulation of histone H3-K4 methylation (GO:0051571)2.55098790
91establishment of pigment granule localization (GO:0051905)2.54756519
92branched-chain amino acid catabolic process (GO:0009083)2.54573479
93binding of sperm to zona pellucida (GO:0007339)2.53949633
94ribosome assembly (GO:0042255)2.53285845
95C4-dicarboxylate transport (GO:0015740)2.52981532
96melanosome transport (GO:0032402)2.52950538
97neuron fate determination (GO:0048664)2.51030779
98retrograde transport, vesicle recycling within Golgi (GO:0000301)2.50492274
99kinetochore organization (GO:0051383)2.50276756
100prenylation (GO:0097354)2.48620491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.10559247
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.29155996
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10978207
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07800937
5ZNF274_21170338_ChIP-Seq_K562_Hela3.05757693
6E2F7_22180533_ChIP-Seq_HELA_Human3.05331126
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.98846359
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.87938568
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.56736400
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.54352435
11GBX2_23144817_ChIP-Seq_PC3_Human2.45795386
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45223609
13FUS_26573619_Chip-Seq_HEK293_Human2.44831509
14VDR_22108803_ChIP-Seq_LS180_Human2.43683376
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40384935
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35790415
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35390536
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32621400
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29586955
20IRF1_19129219_ChIP-ChIP_H3396_Human2.25463486
21* ELK1_19687146_ChIP-ChIP_HELA_Human2.19072783
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18412818
23IGF1R_20145208_ChIP-Seq_DFB_Human2.17619952
24EWS_26573619_Chip-Seq_HEK293_Human2.13061107
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12198865
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03048484
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.89075634
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88560354
29P300_19829295_ChIP-Seq_ESCs_Human1.83125118
30* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82545473
31VDR_23849224_ChIP-Seq_CD4+_Human1.82398317
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74861458
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64333472
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63623809
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61460127
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.59705026
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57526909
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56479695
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50309839
40FOXP3_21729870_ChIP-Seq_TREG_Human1.50253205
41* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48003773
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47047768
43CBP_20019798_ChIP-Seq_JUKART_Human1.47047768
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46214750
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45723481
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.45529676
47TAF15_26573619_Chip-Seq_HEK293_Human1.37506618
48TP53_22573176_ChIP-Seq_HFKS_Human1.35076620
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33508981
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31775646
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30789101
52* MYC_18940864_ChIP-ChIP_HL60_Human1.29560151
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29096963
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.29009833
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28376794
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28008322
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.27557687
58SMAD4_21799915_ChIP-Seq_A2780_Human1.26036391
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25451319
60AR_25329375_ChIP-Seq_VCAP_Human1.22173352
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21705572
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21471944
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19587646
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18831279
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18728983
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17141298
67STAT3_23295773_ChIP-Seq_U87_Human1.16910238
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15639461
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14836934
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.12782010
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10151330
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10151330
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08324127
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.08324127
75NANOG_19829295_ChIP-Seq_ESCs_Human1.07759377
76SOX2_19829295_ChIP-Seq_ESCs_Human1.07759377
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06827069
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.06748498
79TCF4_23295773_ChIP-Seq_U87_Human1.05932906
80ER_23166858_ChIP-Seq_MCF-7_Human1.04815157
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.03941850
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.03759504
83RUNX2_22187159_ChIP-Seq_PCA_Human1.01852699
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.01637093
85BCAT_22108803_ChIP-Seq_LS180_Human1.01529848
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97972829
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97837132
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.97346712
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95789006
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95513986
91GABP_19822575_ChIP-Seq_HepG2_Human0.95125903
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94148774
93SALL4_22934838_ChIP-ChIP_CD34+_Human0.94045655
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93865541
95JUN_21703547_ChIP-Seq_K562_Human0.93685566
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.93551212
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93543205
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.93530975
99RNF2_27304074_Chip-Seq_NSC_Mouse0.93298495
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90804675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.92791144
2MP0006292_abnormal_olfactory_placode4.43538906
3MP0008789_abnormal_olfactory_epithelium3.76902036
4MP0003718_maternal_effect3.37676118
5MP0005499_abnormal_olfactory_system3.06234733
6MP0005394_taste/olfaction_phenotype3.06234733
7MP0002102_abnormal_ear_morphology2.85949571
8MP0009697_abnormal_copulation2.83380017
9MP0008058_abnormal_DNA_repair2.79241210
10MP0006072_abnormal_retinal_apoptosis2.70910978
11MP0001984_abnormal_olfaction2.70824762
12MP0003121_genomic_imprinting2.39715688
13MP0003011_delayed_dark_adaptation2.35752861
14MP0003787_abnormal_imprinting2.35415669
15MP0010094_abnormal_chromosome_stability2.27930029
16MP0005084_abnormal_gallbladder_morpholo2.22974618
17MP0003195_calcinosis2.20077479
18MP0005551_abnormal_eye_electrophysiolog2.02054389
19MP0003122_maternal_imprinting1.92118576
20MP0003567_abnormal_fetal_cardiomyocyte1.91738049
21MP0005253_abnormal_eye_physiology1.82951265
22MP0010030_abnormal_orbit_morphology1.82614895
23MP0002928_abnormal_bile_duct1.78512796
24MP0003880_abnormal_central_pattern1.72667843
25MP0005171_absent_coat_pigmentation1.71424553
26MP0000372_irregular_coat_pigmentation1.70071265
27MP0001529_abnormal_vocalization1.66225397
28MP0005395_other_phenotype1.59502209
29MP0006276_abnormal_autonomic_nervous1.55770030
30MP0001293_anophthalmia1.52681198
31MP0003693_abnormal_embryo_hatching1.48751202
32MP0000631_abnormal_neuroendocrine_gland1.42722228
33MP0005083_abnormal_biliary_tract1.38161042
34MP0001929_abnormal_gametogenesis1.33688099
35MP0002163_abnormal_gland_morphology1.32162355
36MP0003077_abnormal_cell_cycle1.31890336
37MP0001324_abnormal_eye_pigmentation1.31512936
38MP0002638_abnormal_pupillary_reflex1.25968274
39MP0005367_renal/urinary_system_phenotyp1.25091045
40MP0000516_abnormal_urinary_system1.25091045
41MP0005410_abnormal_fertilization1.23959887
42MP0001986_abnormal_taste_sensitivity1.23772548
43MP0003111_abnormal_nucleus_morphology1.20872473
44MP0005379_endocrine/exocrine_gland_phen1.20635732
45MP0001764_abnormal_homeostasis1.19244556
46MP0005220_abnormal_exocrine_pancreas1.18784797
47MP0002210_abnormal_sex_determination1.17305124
48MP0002095_abnormal_skin_pigmentation1.16489885
49MP0004142_abnormal_muscle_tone1.15525674
50MP0008932_abnormal_embryonic_tissue1.08024304
51MP0005195_abnormal_posterior_eye1.07235078
52MP0005085_abnormal_gallbladder_physiolo1.05551882
53MP0002233_abnormal_nose_morphology1.04905606
54MP0000778_abnormal_nervous_system1.03044174
55MP0000427_abnormal_hair_cycle1.02730648
56MP0008057_abnormal_DNA_replication1.01921008
57MP0002736_abnormal_nociception_after0.98835285
58MP0005391_vision/eye_phenotype0.98305086
59MP0000569_abnormal_digit_pigmentation0.97508101
60MP0003252_abnormal_bile_duct0.96049904
61MP0002138_abnormal_hepatobiliary_system0.95617873
62MP0002272_abnormal_nervous_system0.89073315
63MP0000653_abnormal_sex_gland0.87939838
64MP0004215_abnormal_myocardial_fiber0.87739288
65MP0002752_abnormal_somatic_nervous0.87174847
66MP0006035_abnormal_mitochondrial_morpho0.87061788
67MP0003698_abnormal_male_reproductive0.85845317
68MP0002234_abnormal_pharynx_morphology0.85806304
69MP0005646_abnormal_pituitary_gland0.85519592
70MP0002751_abnormal_autonomic_nervous0.84872996
71MP0008775_abnormal_heart_ventricle0.84796118
72MP0003119_abnormal_digestive_system0.83718016
73MP0001502_abnormal_circadian_rhythm0.81829069
74MP0002557_abnormal_social/conspecific_i0.80305638
75MP0003136_yellow_coat_color0.77408045
76MP0003186_abnormal_redox_activity0.77305261
77MP0000647_abnormal_sebaceous_gland0.76480044
78MP0001119_abnormal_female_reproductive0.76077969
79MP0001145_abnormal_male_reproductive0.73147241
80MP0003221_abnormal_cardiomyocyte_apopto0.72557477
81MP0000358_abnormal_cell_content/0.72477870
82MP0003890_abnormal_embryonic-extraembry0.72392650
83MP0001286_abnormal_eye_development0.72092059
84MP0002161_abnormal_fertility/fecundity0.71696834
85MP0003183_abnormal_peptide_metabolism0.71666014
86MP0009046_muscle_twitch0.70757154
87MP0005248_abnormal_Harderian_gland0.68152912
88MP0006036_abnormal_mitochondrial_physio0.67791674
89MP0002229_neurodegeneration0.67149101
90MP0002938_white_spotting0.67129598
91MP0000049_abnormal_middle_ear0.66758583
92MP0000026_abnormal_inner_ear0.66274538
93MP0003699_abnormal_female_reproductive0.65814209
94MP0001968_abnormal_touch/_nociception0.65259706
95MP0003943_abnormal_hepatobiliary_system0.64996793
96MP0001486_abnormal_startle_reflex0.64154868
97MP0002069_abnormal_eating/drinking_beha0.61327015
98MP0002837_dystrophic_cardiac_calcinosis0.61094496
99MP0002090_abnormal_vision0.60918221
100MP0003755_abnormal_palate_morphology0.60582206

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)3.78767152
2Hypoglycemic seizures (HP:0002173)3.78218905
3Hypokinesia (HP:0002375)3.62167174
4Tubulointerstitial nephritis (HP:0001970)3.60567803
5Molar tooth sign on MRI (HP:0002419)3.46461330
6Abnormality of midbrain morphology (HP:0002418)3.46461330
7Abnormality of the metopic suture (HP:0005556)3.36288742
8Medial flaring of the eyebrow (HP:0010747)3.24795358
9Prominent metopic ridge (HP:0005487)3.21174307
10Symptomatic seizures (HP:0011145)3.15499170
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.06999056
12Hyperinsulinemic hypoglycemia (HP:0000825)3.02445084
13Nephronophthisis (HP:0000090)2.99225791
14Pancreatic cysts (HP:0001737)2.95741697
15Abnormality of the labia minora (HP:0012880)2.92380812
16Type II lissencephaly (HP:0007260)2.88711813
17Retinal dysplasia (HP:0007973)2.83742322
18Abnormality of chromosome stability (HP:0003220)2.83243496
19Congenital primary aphakia (HP:0007707)2.75331935
20Gait imbalance (HP:0002141)2.73008610
21Ketoacidosis (HP:0001993)2.68303751
22Supernumerary spleens (HP:0009799)2.63740651
23Pancreatic fibrosis (HP:0100732)2.61432570
24Chromsome breakage (HP:0040012)2.61324011
25Meckel diverticulum (HP:0002245)2.59123995
26Abnormality of the ileum (HP:0001549)2.55456892
27True hermaphroditism (HP:0010459)2.48116977
28Abnormality of the preputium (HP:0100587)2.48036988
29Congenital sensorineural hearing impairment (HP:0008527)2.43920290
30Gonadotropin excess (HP:0000837)2.43761581
31Hypothermia (HP:0002045)2.42960064
32Abnormality of the renal medulla (HP:0100957)2.42882593
33Progressive inability to walk (HP:0002505)2.40506274
34Septo-optic dysplasia (HP:0100842)2.40375316
35Progressive macrocephaly (HP:0004481)2.39308877
36Chronic hepatic failure (HP:0100626)2.38051866
37Abnormality of the renal cortex (HP:0011035)2.34882263
38Nephrogenic diabetes insipidus (HP:0009806)2.34385128
39Renal cortical cysts (HP:0000803)2.31726154
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30621686
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.28583938
42Poor coordination (HP:0002370)2.26316962
43Acute necrotizing encephalopathy (HP:0006965)2.26204405
44Cerebellar dysplasia (HP:0007033)2.26131764
45Oligodactyly (hands) (HP:0001180)2.25897664
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.18065737
47Hypoplasia of the fovea (HP:0007750)2.18065737
48Abnormality of DNA repair (HP:0003254)2.15447616
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.14649970
50Abnormality of the anterior horn cell (HP:0006802)2.14507359
51Degeneration of anterior horn cells (HP:0002398)2.14507359
52Short tibia (HP:0005736)2.13947431
53Anterior segment dysgenesis (HP:0007700)2.10328087
54Abnormal hair whorl (HP:0010721)2.08134337
55Ketosis (HP:0001946)2.06245221
56Oligodactyly (HP:0012165)2.06015788
57Methylmalonic acidemia (HP:0002912)2.04906044
58Median cleft lip (HP:0000161)2.03237043
59Narrow forehead (HP:0000341)2.01644867
603-Methylglutaconic aciduria (HP:0003535)1.99098678
61Neoplasm of the adrenal cortex (HP:0100641)1.99020138
62Facial hemangioma (HP:0000329)1.98805303
63Abnormal gallbladder physiology (HP:0012438)1.98685054
64Cholecystitis (HP:0001082)1.98685054
65Diminished movement (HP:0002374)1.97930615
66Abnormality of the fovea (HP:0000493)1.97003991
67Genital tract atresia (HP:0001827)1.96999312
68Abolished electroretinogram (ERG) (HP:0000550)1.95943890
69Bile duct proliferation (HP:0001408)1.94776885
70Abnormal biliary tract physiology (HP:0012439)1.94776885
71Abnormality of the carotid arteries (HP:0005344)1.94357979
72Astigmatism (HP:0000483)1.93675150
73Hepatic necrosis (HP:0002605)1.89749735
74Colon cancer (HP:0003003)1.88345824
75Increased CSF lactate (HP:0002490)1.88021280
76Abnormal mitochondria in muscle tissue (HP:0008316)1.85402208
77Postaxial hand polydactyly (HP:0001162)1.85092320
78Abnormality of endocrine pancreas physiology (HP:0012093)1.85029661
79Abnormality of the pancreatic islet cells (HP:0006476)1.85029661
80Poor suck (HP:0002033)1.84712052
81Lissencephaly (HP:0001339)1.82070683
82Vaginal atresia (HP:0000148)1.81777930
83Aganglionic megacolon (HP:0002251)1.81771611
84Birth length less than 3rd percentile (HP:0003561)1.81489195
85Atrophy/Degeneration involving motor neurons (HP:0007373)1.80790842
86Anencephaly (HP:0002323)1.80149861
87Acute encephalopathy (HP:0006846)1.78537297
88Duodenal stenosis (HP:0100867)1.78182874
89Small intestinal stenosis (HP:0012848)1.78182874
90Capillary hemangiomas (HP:0005306)1.77618947
91Optic nerve hypoplasia (HP:0000609)1.77188748
92Growth hormone deficiency (HP:0000824)1.76129707
93Methylmalonic aciduria (HP:0012120)1.75951449
94Impulsivity (HP:0100710)1.75192322
95Pancreatic islet-cell hyperplasia (HP:0004510)1.74985787
96Azoospermia (HP:0000027)1.73333583
97Clubbing of toes (HP:0100760)1.73280392
98Lower limb hyperreflexia (HP:0002395)1.73262408
99Hyperglycinemia (HP:0002154)1.72193107
100Sloping forehead (HP:0000340)1.72086361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.13895733
2FRK3.03862918
3MAP4K22.85280650
4TNIK2.79416352
5WNK32.76115537
6EIF2AK32.71771996
7INSRR2.57290334
8NUAK12.55305491
9TRIM282.54805728
10TAOK32.51552156
11MAP3K92.40345410
12BCKDK2.21220562
13SRPK12.15938092
14TSSK62.12664822
15MAP2K71.99882909
16MAP3K41.81467284
17CDC71.78325876
18PLK21.77489658
19PASK1.70350570
20PAK31.68523933
21BCR1.67678076
22MAP3K131.59114150
23MAPK131.52300994
24WEE11.48100125
25NME11.47327471
26BMPR1B1.38653334
27ERBB31.28986915
28ARAF1.18709210
29PLK41.15572131
30PLK31.14049752
31MKNK21.12204792
32CDK191.08850129
33PLK11.08418265
34CSNK1G11.01617394
35ZAK1.00338893
36TTK0.99461505
37ADRBK20.98463953
38BRSK20.97969103
39RAF10.97177284
40EPHA40.93893867
41CSNK1G20.92841948
42PINK10.92589902
43CDK30.90457611
44VRK10.87185745
45BRAF0.86748100
46STK30.85648288
47GRK10.83579924
48MKNK10.83218351
49CSNK1G30.81308773
50CCNB10.78987693
51NEK60.76508324
52PAK60.76205790
53AURKA0.75813561
54NTRK20.75298893
55MST40.74866132
56ATM0.74397130
57NLK0.73157285
58PRKCE0.72213992
59IRAK10.71494726
60CASK0.69526895
61ATR0.67762122
62STK390.62609322
63PRKCG0.62579812
64KSR20.62136357
65KSR10.61419819
66MAP3K50.61129405
67BUB10.59835035
68TIE10.59097869
69PRKCI0.58696462
70DYRK20.58045669
71AURKB0.57439619
72CHEK10.57364198
73CHEK20.55139237
74PNCK0.49421407
75WNK10.49291284
76PRKCQ0.48703080
77TGFBR10.47630658
78CSNK1A1L0.47047885
79EIF2AK20.46980048
80ADRBK10.46914410
81BRSK10.46848564
82OXSR10.45905136
83PRKAA10.43553219
84LATS10.43211484
85ERBB40.42078707
86PIK3CG0.40651435
87CSNK1E0.40178466
88WNK40.39481444
89CSNK2A20.39438924
90PRKACB0.39393422
91RPS6KA40.39297833
92IKBKE0.39036192
93CSNK1D0.38950847
94PRKCZ0.37724748
95CDK140.37481329
96CDK10.36188489
97CSNK1A10.35078504
98PKN10.34585326
99EIF2AK10.34196392
100MAP3K60.34117654

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.00532604
2Fanconi anemia pathway_Homo sapiens_hsa034603.55142255
3Basal transcription factors_Homo sapiens_hsa030223.44362581
4Homologous recombination_Homo sapiens_hsa034403.31810980
5Protein export_Homo sapiens_hsa030602.62491403
6Mismatch repair_Homo sapiens_hsa034302.61268307
7Non-homologous end-joining_Homo sapiens_hsa034502.40866632
8Butanoate metabolism_Homo sapiens_hsa006502.38367586
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30021191
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25596997
11RNA degradation_Homo sapiens_hsa030182.23524168
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22765398
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14272669
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14080997
15Selenocompound metabolism_Homo sapiens_hsa004502.05074729
16Phototransduction_Homo sapiens_hsa047442.03465180
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02926311
18DNA replication_Homo sapiens_hsa030301.98617740
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.98086080
20Steroid biosynthesis_Homo sapiens_hsa001001.96647336
21Base excision repair_Homo sapiens_hsa034101.91307199
22Proteasome_Homo sapiens_hsa030501.89922651
23RNA transport_Homo sapiens_hsa030131.71938900
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70624815
25Oxidative phosphorylation_Homo sapiens_hsa001901.66772345
26RNA polymerase_Homo sapiens_hsa030201.61335968
27Nucleotide excision repair_Homo sapiens_hsa034201.60524398
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54799393
29Parkinsons disease_Homo sapiens_hsa050121.51294801
30Regulation of autophagy_Homo sapiens_hsa041401.51240190
31Propanoate metabolism_Homo sapiens_hsa006401.50524263
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49391756
33Cell cycle_Homo sapiens_hsa041101.42993067
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36316434
35mRNA surveillance pathway_Homo sapiens_hsa030151.33043456
36Fatty acid elongation_Homo sapiens_hsa000621.32467699
37Purine metabolism_Homo sapiens_hsa002301.32366555
38Spliceosome_Homo sapiens_hsa030401.32297418
39Collecting duct acid secretion_Homo sapiens_hsa049661.24054332
40Huntingtons disease_Homo sapiens_hsa050161.19995983
41Nicotine addiction_Homo sapiens_hsa050331.13295566
42Olfactory transduction_Homo sapiens_hsa047401.08617104
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.95501436
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94014488
45Caffeine metabolism_Homo sapiens_hsa002320.91034765
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90941451
47Peroxisome_Homo sapiens_hsa041460.87978029
48Dorso-ventral axis formation_Homo sapiens_hsa043200.87440948
49Taste transduction_Homo sapiens_hsa047420.87291258
50Pyrimidine metabolism_Homo sapiens_hsa002400.87006463
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83303598
52p53 signaling pathway_Homo sapiens_hsa041150.80217970
53Oocyte meiosis_Homo sapiens_hsa041140.78325349
54Tryptophan metabolism_Homo sapiens_hsa003800.77843436
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.77786985
56Cardiac muscle contraction_Homo sapiens_hsa042600.73211229
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71998127
58Morphine addiction_Homo sapiens_hsa050320.68650033
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64698079
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63671552
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62646390
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61148603
63One carbon pool by folate_Homo sapiens_hsa006700.58770112
64Alzheimers disease_Homo sapiens_hsa050100.57182447
65Ovarian steroidogenesis_Homo sapiens_hsa049130.56193596
66Ether lipid metabolism_Homo sapiens_hsa005650.56056581
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54413026
68Metabolic pathways_Homo sapiens_hsa011000.54100398
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49263613
70Legionellosis_Homo sapiens_hsa051340.41221225
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40175978
72Inositol phosphate metabolism_Homo sapiens_hsa005620.39937679
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39692184
74Lysine degradation_Homo sapiens_hsa003100.39588136
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39059879
76ABC transporters_Homo sapiens_hsa020100.38822631
77Linoleic acid metabolism_Homo sapiens_hsa005910.36086995
78GABAergic synapse_Homo sapiens_hsa047270.33494851
79Circadian rhythm_Homo sapiens_hsa047100.31603257
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.31070024
81Long-term depression_Homo sapiens_hsa047300.30627879
82Serotonergic synapse_Homo sapiens_hsa047260.30583090
83Glutathione metabolism_Homo sapiens_hsa004800.29290072
84Type II diabetes mellitus_Homo sapiens_hsa049300.26732485
85Retinol metabolism_Homo sapiens_hsa008300.24983510
86Arachidonic acid metabolism_Homo sapiens_hsa005900.24552286
87Insulin secretion_Homo sapiens_hsa049110.23504186
88Arginine and proline metabolism_Homo sapiens_hsa003300.22287608
89Fatty acid metabolism_Homo sapiens_hsa012120.18982619
90Glutamatergic synapse_Homo sapiens_hsa047240.17464279
91Synaptic vesicle cycle_Homo sapiens_hsa047210.15286337
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14423787
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13829290
94Chemical carcinogenesis_Homo sapiens_hsa052040.13547846
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.13273358
96Dopaminergic synapse_Homo sapiens_hsa047280.12518094
97Alcoholism_Homo sapiens_hsa050340.11444615
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.11428396
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11246566
100Rheumatoid arthritis_Homo sapiens_hsa053230.11165443

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