ZNF223

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)4.21984657
2respiratory chain complex IV assembly (GO:0008535)4.10682315
3L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.07820499
4pyrimidine nucleobase catabolic process (GO:0006208)3.99039820
5platelet dense granule organization (GO:0060155)3.77366396
6seminiferous tubule development (GO:0072520)3.65126768
7cytochrome complex assembly (GO:0017004)3.63511542
8peptidyl-histidine modification (GO:0018202)3.60707725
9single strand break repair (GO:0000012)3.58457600
10regulation of cilium movement (GO:0003352)3.55226332
11response to pheromone (GO:0019236)3.54996613
12protein-cofactor linkage (GO:0018065)3.50739587
13positive regulation of prostaglandin secretion (GO:0032308)3.50515980
14DNA double-strand break processing (GO:0000729)3.48398731
15nonmotile primary cilium assembly (GO:0035058)3.47007723
16anterograde synaptic vesicle transport (GO:0048490)3.45099130
17protein complex biogenesis (GO:0070271)3.44582678
18preassembly of GPI anchor in ER membrane (GO:0016254)3.42593389
19mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.41962211
20positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.41962211
21protein deneddylation (GO:0000338)3.41109903
22piRNA metabolic process (GO:0034587)3.39567653
23mitochondrial respiratory chain complex assembly (GO:0033108)3.39208937
24negative regulation of telomere maintenance (GO:0032205)3.37560210
25regulation of meiosis I (GO:0060631)3.36885953
26behavioral response to nicotine (GO:0035095)3.36596636
27cullin deneddylation (GO:0010388)3.34556982
28C4-dicarboxylate transport (GO:0015740)3.32524027
29nucleobase catabolic process (GO:0046113)3.28728707
30aggressive behavior (GO:0002118)3.28586723
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.27851229
32NADH dehydrogenase complex assembly (GO:0010257)3.27851229
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27851229
34amino acid salvage (GO:0043102)3.21449064
35L-methionine salvage (GO:0071267)3.21449064
36L-methionine biosynthetic process (GO:0071265)3.21449064
37intraciliary transport (GO:0042073)3.18256260
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17109166
39regulation of helicase activity (GO:0051095)3.14619099
40histone H2A acetylation (GO:0043968)3.13062154
41water-soluble vitamin biosynthetic process (GO:0042364)3.05908410
42indole-containing compound catabolic process (GO:0042436)3.04290595
43indolalkylamine catabolic process (GO:0046218)3.04290595
44tryptophan catabolic process (GO:0006569)3.04290595
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02749710
46cilium morphogenesis (GO:0060271)3.01281974
47regulation of prostaglandin secretion (GO:0032306)2.96762441
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93193292
49behavioral response to ethanol (GO:0048149)2.92882564
50photoreceptor cell maintenance (GO:0045494)2.92842901
51inositol phosphate catabolic process (GO:0071545)2.89438111
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88481625
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88481625
54regulation of collateral sprouting (GO:0048670)2.77343729
55mannosylation (GO:0097502)2.77319994
56DNA damage response, detection of DNA damage (GO:0042769)2.75858361
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75444168
58regulation of mitotic spindle checkpoint (GO:1903504)2.75444168
59keratinocyte development (GO:0003334)2.73505834
60indolalkylamine metabolic process (GO:0006586)2.71454962
61GPI anchor metabolic process (GO:0006505)2.71207269
62base-excision repair, AP site formation (GO:0006285)2.68564132
63negative regulation of JAK-STAT cascade (GO:0046426)2.68329921
64peroxisome organization (GO:0007031)2.65906205
65melanosome transport (GO:0032402)2.63414636
66negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62216634
67C-terminal protein lipidation (GO:0006501)2.60790600
68protein polyglutamylation (GO:0018095)2.60491748
69tryptophan metabolic process (GO:0006568)2.59524172
70regulation of telomere maintenance (GO:0032204)2.58053929
71GPI anchor biosynthetic process (GO:0006506)2.57205589
72pigment granule transport (GO:0051904)2.55188258
73establishment of melanosome localization (GO:0032401)2.54804004
74positive regulation of fatty acid transport (GO:2000193)2.53866843
75cilium organization (GO:0044782)2.52620806
76regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.52175642
77negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.51917081
78negative regulation of appetite (GO:0032099)2.51007524
79negative regulation of response to food (GO:0032096)2.51007524
80cilium assembly (GO:0042384)2.49128022
81establishment of pigment granule localization (GO:0051905)2.47309669
82dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.45748984
83positive regulation of icosanoid secretion (GO:0032305)2.45665743
84response to nitrosative stress (GO:0051409)2.44504816
85cholesterol biosynthetic process (GO:0006695)2.43752825
86lipid particle organization (GO:0034389)2.43458532
87negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43056749
88C-terminal protein amino acid modification (GO:0018410)2.42125457
89branched-chain amino acid catabolic process (GO:0009083)2.41932079
90regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40831675
91reflex (GO:0060004)2.40497361
92brain morphogenesis (GO:0048854)2.39544831
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39452938
94kynurenine metabolic process (GO:0070189)2.38937934
95protein neddylation (GO:0045116)2.36941345
96iron-sulfur cluster assembly (GO:0016226)2.36305801
97metallo-sulfur cluster assembly (GO:0031163)2.36305801
98transepithelial transport (GO:0070633)2.36210656
99epithelial cilium movement (GO:0003351)2.36188031
100establishment of protein localization to peroxisome (GO:0072663)2.35442750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.15678826
2IGF1R_20145208_ChIP-Seq_DFB_Human3.35938618
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87068285
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80691946
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63414001
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61598505
7GBX2_23144817_ChIP-Seq_PC3_Human2.57952281
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47552308
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45632033
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.44703387
11TAF15_26573619_Chip-Seq_HEK293_Human2.39616030
12VDR_22108803_ChIP-Seq_LS180_Human2.38491942
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34806490
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.32919492
15FUS_26573619_Chip-Seq_HEK293_Human2.31087886
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.24292077
17P300_19829295_ChIP-Seq_ESCs_Human2.20983180
18EZH2_22144423_ChIP-Seq_EOC_Human2.19838671
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19623548
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11417482
21EWS_26573619_Chip-Seq_HEK293_Human2.05951395
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.03805726
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02109636
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90752095
25* ELK1_19687146_ChIP-ChIP_HELA_Human1.88633263
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79333640
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74418365
28ER_23166858_ChIP-Seq_MCF-7_Human1.69837321
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61828766
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60564572
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58751274
32SMAD4_21799915_ChIP-Seq_A2780_Human1.54520459
33CBP_20019798_ChIP-Seq_JUKART_Human1.51620604
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51620604
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51411926
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50943947
37VDR_23849224_ChIP-Seq_CD4+_Human1.50160363
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48754205
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.46754917
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41493260
41BCAT_22108803_ChIP-Seq_LS180_Human1.41299420
42TP53_22573176_ChIP-Seq_HFKS_Human1.40432400
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38936097
44NANOG_19829295_ChIP-Seq_ESCs_Human1.38917508
45SOX2_19829295_ChIP-Seq_ESCs_Human1.38917508
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38786578
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38042436
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37441712
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36617346
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.36214950
51IRF1_19129219_ChIP-ChIP_H3396_Human1.35752702
52* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33969920
53TCF4_22108803_ChIP-Seq_LS180_Human1.33136299
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.32481580
55* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32053957
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30352252
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29765891
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29418261
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28835897
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28270202
61STAT3_23295773_ChIP-Seq_U87_Human1.27496519
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26686776
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25526837
64FOXP3_21729870_ChIP-Seq_TREG_Human1.25262940
65AR_25329375_ChIP-Seq_VCAP_Human1.25205453
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25116767
67RNF2_27304074_Chip-Seq_NSC_Mouse1.23643582
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23182205
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23023037
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.22824209
71MYC_18940864_ChIP-ChIP_HL60_Human1.22726334
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.21617747
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.19970236
74TCF4_23295773_ChIP-Seq_U87_Human1.19343678
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.18842064
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.16518577
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.16330086
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16122001
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.15037881
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15037881
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13083403
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11950040
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11701910
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11259410
85AR_20517297_ChIP-Seq_VCAP_Human1.10355596
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09414143
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07610020
88RUNX2_22187159_ChIP-Seq_PCA_Human1.06511420
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.06058734
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06005196
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05294869
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05203951
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05203951
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.04179626
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03782654
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.03722579
97P53_22387025_ChIP-Seq_ESCs_Mouse1.03291905
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.98622369
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.97633516
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.96329823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo3.67885853
2MP0004147_increased_porphyrin_level2.90768004
3MP0006276_abnormal_autonomic_nervous2.86244781
4MP0008058_abnormal_DNA_repair2.83626025
5MP0003195_calcinosis2.79616882
6MP0008877_abnormal_DNA_methylation2.72522971
7MP0001529_abnormal_vocalization2.67558232
8MP0003011_delayed_dark_adaptation2.64680708
9MP0008789_abnormal_olfactory_epithelium2.48624917
10MP0001968_abnormal_touch/_nociception2.40270484
11MP0000569_abnormal_digit_pigmentation2.38881353
12MP0003880_abnormal_central_pattern2.13936354
13MP0002837_dystrophic_cardiac_calcinosis2.10511549
14MP0005499_abnormal_olfactory_system2.04718198
15MP0005394_taste/olfaction_phenotype2.04718198
16MP0005379_endocrine/exocrine_gland_phen1.97740772
17MP0001984_abnormal_olfaction1.91993559
18MP0002736_abnormal_nociception_after1.87596391
19MP0004043_abnormal_pH_regulation1.83735787
20MP0006072_abnormal_retinal_apoptosis1.83130471
21MP0003252_abnormal_bile_duct1.81101709
22MP0005253_abnormal_eye_physiology1.78791522
23MP0002102_abnormal_ear_morphology1.71563749
24MP0005551_abnormal_eye_electrophysiolog1.69348255
25MP0002163_abnormal_gland_morphology1.64383697
26MP0003787_abnormal_imprinting1.63887081
27MP0002138_abnormal_hepatobiliary_system1.61757510
28MP0004133_heterotaxia1.60924002
29MP0004270_analgesia1.58346537
30MP0001764_abnormal_homeostasis1.52681615
31MP0006292_abnormal_olfactory_placode1.52295833
32MP0008872_abnormal_physiological_respon1.45891814
33MP0009697_abnormal_copulation1.44391300
34MP0000372_irregular_coat_pigmentation1.44044592
35MP0009046_muscle_twitch1.43319578
36MP0003718_maternal_effect1.42597329
37MP0005085_abnormal_gallbladder_physiolo1.42487099
38MP0002938_white_spotting1.40895652
39MP0002272_abnormal_nervous_system1.39198509
40MP0003122_maternal_imprinting1.38855181
41MP0002822_catalepsy1.36982585
42MP0005365_abnormal_bile_salt1.33787543
43MP0003890_abnormal_embryonic-extraembry1.33312950
44MP0001986_abnormal_taste_sensitivity1.32295941
45MP0001486_abnormal_startle_reflex1.30404145
46MP0003121_genomic_imprinting1.26076914
47MP0009745_abnormal_behavioral_response1.25026356
48MP0002751_abnormal_autonomic_nervous1.23514472
49MP0000516_abnormal_urinary_system1.21636549
50MP0005367_renal/urinary_system_phenotyp1.21636549
51MP0005645_abnormal_hypothalamus_physiol1.20954734
52MP0002572_abnormal_emotion/affect_behav1.20569950
53MP0002735_abnormal_chemical_nociception1.20523588
54MP0002928_abnormal_bile_duct1.19794714
55MP0002557_abnormal_social/conspecific_i1.18985303
56MP0004142_abnormal_muscle_tone1.14876318
57MP0003137_abnormal_impulse_conducting1.14790102
58MP0002638_abnormal_pupillary_reflex1.14118216
59MP0002734_abnormal_mechanical_nocicepti1.12367664
60MP0002733_abnormal_thermal_nociception1.11849313
61MP0001970_abnormal_pain_threshold1.10844156
62MP0000230_abnormal_systemic_arterial1.10815330
63MP0004215_abnormal_myocardial_fiber1.10507323
64MP0002160_abnormal_reproductive_system1.07811178
65MP0000647_abnormal_sebaceous_gland1.07198838
66MP0000778_abnormal_nervous_system1.06096133
67MP0003303_peritoneal_inflammation1.04087517
68MP0002064_seizures1.00968796
69MP0002233_abnormal_nose_morphology1.00553050
70MP0001485_abnormal_pinna_reflex0.99948549
71MP0005174_abnormal_tail_pigmentation0.99590011
72MP0005075_abnormal_melanosome_morpholog0.98457621
73MP0003635_abnormal_synaptic_transmissio0.97702628
74MP0000631_abnormal_neuroendocrine_gland0.96927385
75MP0005646_abnormal_pituitary_gland0.96358208
76MP0004924_abnormal_behavior0.95429801
77MP0005386_behavior/neurological_phenoty0.95429801
78MP0005187_abnormal_penis_morphology0.93028983
79MP0002184_abnormal_innervation0.91832530
80MP0001501_abnormal_sleep_pattern0.90520811
81MP0002282_abnormal_trachea_morphology0.88914754
82MP0000427_abnormal_hair_cycle0.88321284
83MP0001929_abnormal_gametogenesis0.86659175
84MP0002067_abnormal_sensory_capabilities0.86323494
85MP0003698_abnormal_male_reproductive0.85968857
86MP0002063_abnormal_learning/memory/cond0.85450555
87MP0001664_abnormal_digestion0.82876306
88MP0005220_abnormal_exocrine_pancreas0.82850864
89MP0006036_abnormal_mitochondrial_physio0.82587130
90MP0010094_abnormal_chromosome_stability0.82326416
91MP0005083_abnormal_biliary_tract0.80597626
92MP0002876_abnormal_thyroid_physiology0.79136944
93MP0005389_reproductive_system_phenotype0.78145462
94MP0010386_abnormal_urinary_bladder0.77355272
95MP0010329_abnormal_lipoprotein_level0.76266784
96MP0003633_abnormal_nervous_system0.75566607
97MP0002090_abnormal_vision0.75498464
98MP0002752_abnormal_somatic_nervous0.75150364
99MP0006035_abnormal_mitochondrial_morpho0.73951841
100MP0008875_abnormal_xenobiotic_pharmacok0.73939836

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.84415325
2Molar tooth sign on MRI (HP:0002419)3.50824638
3Abnormality of midbrain morphology (HP:0002418)3.50824638
4Pancreatic cysts (HP:0001737)3.17950506
5Gait imbalance (HP:0002141)3.17820801
6Acute necrotizing encephalopathy (HP:0006965)3.16886091
7Congenital primary aphakia (HP:0007707)3.15077004
8Abolished electroretinogram (ERG) (HP:0000550)3.14378896
9Abnormality of the labia minora (HP:0012880)3.05854967
10Genital tract atresia (HP:0001827)3.05658356
11Vaginal atresia (HP:0000148)2.99706700
12Hypothermia (HP:0002045)2.93286425
13Acute encephalopathy (HP:0006846)2.90434403
14Nephrogenic diabetes insipidus (HP:0009806)2.85519844
15Progressive macrocephaly (HP:0004481)2.81943031
16Nephronophthisis (HP:0000090)2.81206015
17Chronic hepatic failure (HP:0100626)2.78305963
18Abnormal mitochondria in muscle tissue (HP:0008316)2.76231847
19Colon cancer (HP:0003003)2.74992405
20Mitochondrial inheritance (HP:0001427)2.74697906
21Increased CSF lactate (HP:0002490)2.72526566
22Pancreatic fibrosis (HP:0100732)2.71893893
23Hyperventilation (HP:0002883)2.71736235
24Hepatocellular necrosis (HP:0001404)2.71694402
25True hermaphroditism (HP:0010459)2.52481988
26Hepatic necrosis (HP:0002605)2.51608329
27Abnormal biliary tract physiology (HP:0012439)2.46716184
28Bile duct proliferation (HP:0001408)2.46716184
29Abnormality of the renal medulla (HP:0100957)2.41842047
30Adactyly (HP:0009776)2.37980097
31Bifid tongue (HP:0010297)2.36434266
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.34521622
33Short tibia (HP:0005736)2.33756134
34Lissencephaly (HP:0001339)2.31741775
35Retinal dysplasia (HP:0007973)2.28595293
36Type II lissencephaly (HP:0007260)2.23877262
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19092245
38Abnormal protein N-linked glycosylation (HP:0012347)2.19092245
39Abnormal protein glycosylation (HP:0012346)2.19092245
40Abnormal glycosylation (HP:0012345)2.19092245
41Abnormality of the renal cortex (HP:0011035)2.17212745
42Methylmalonic acidemia (HP:0002912)2.15161402
43Poor coordination (HP:0002370)2.13915259
44Pendular nystagmus (HP:0012043)2.07155161
453-Methylglutaconic aciduria (HP:0003535)2.04310249
46Tubulointerstitial nephritis (HP:0001970)2.04284831
47Polyphagia (HP:0002591)2.03893957
48Drooling (HP:0002307)2.01547809
49Rectovaginal fistula (HP:0000143)2.01416108
50Rectal fistula (HP:0100590)2.01416108
51Broad-based gait (HP:0002136)1.98658230
52Cerebral edema (HP:0002181)1.97530825
53Hyperglycinemia (HP:0002154)1.97472767
54CNS demyelination (HP:0007305)1.97427573
55Congenital hepatic fibrosis (HP:0002612)1.95883443
56Ependymoma (HP:0002888)1.95854895
57Postaxial hand polydactyly (HP:0001162)1.95532682
58Attenuation of retinal blood vessels (HP:0007843)1.95229613
59Glioma (HP:0009733)1.94768401
60Intestinal atresia (HP:0011100)1.93802058
61Inability to walk (HP:0002540)1.93456519
62Progressive inability to walk (HP:0002505)1.92982355
63Optic disc pallor (HP:0000543)1.91979148
64Renal cortical cysts (HP:0000803)1.91891674
65Increased serum lactate (HP:0002151)1.91336132
66Methylmalonic aciduria (HP:0012120)1.90689875
67Absent speech (HP:0001344)1.90265550
68Atrophy/Degeneration involving motor neurons (HP:0007373)1.88441471
69Amyotrophic lateral sclerosis (HP:0007354)1.87757452
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.84295369
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83808934
72Abnormality of alanine metabolism (HP:0010916)1.83808934
73Hyperalaninemia (HP:0003348)1.83808934
74Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.82998515
75Short 1st metacarpal (HP:0010034)1.82998515
76Disproportionate short-trunk short stature (HP:0003521)1.81011138
77Hip dysplasia (HP:0001385)1.80565391
78Lactic acidosis (HP:0003128)1.80565183
79Abnormality of the metopic suture (HP:0005556)1.80314771
80Anencephaly (HP:0002323)1.79426332
81Postaxial foot polydactyly (HP:0001830)1.79124720
82Retinitis pigmentosa (HP:0000510)1.78209090
83Excessive salivation (HP:0003781)1.77873401
84Pachygyria (HP:0001302)1.77843889
85Abnormality of the astrocytes (HP:0100707)1.77601639
86Astrocytoma (HP:0009592)1.77601639
87Sclerocornea (HP:0000647)1.76736651
88Muscular hypotonia of the trunk (HP:0008936)1.75975666
89Oligodactyly (hands) (HP:0001180)1.75667651
90Broad foot (HP:0001769)1.75665768
91Aplasia/Hypoplasia of the lens (HP:0008063)1.73931010
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.73415794
93Respiratory failure (HP:0002878)1.72290989
94Specific learning disability (HP:0001328)1.72177689
95Fair hair (HP:0002286)1.71535044
96Keratoconus (HP:0000563)1.71359523
97Increased corneal curvature (HP:0100692)1.71359523
98Hypoplastic pelvis (HP:0008839)1.69242879
99Stomach cancer (HP:0012126)1.67603868
100Horseshoe kidney (HP:0000085)1.66803114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.52570680
2WNK33.46723415
3TRIM283.23045692
4FRK3.11625667
5PINK12.99259910
6CASK2.57220262
7MAP3K42.57109193
8NUAK12.51051307
9BCR2.42402321
10ZAK2.32271127
11ADRBK22.09647642
12BMPR1B2.07206712
13MAPK132.03106566
14ACVR1B1.89548613
15ERBB31.75739703
16EPHA41.67294875
17CAMKK21.58108337
18EIF2AK31.56968637
19MKNK21.55392758
20MAP2K71.49423905
21PLK41.47977536
22GRK11.47457008
23MKNK11.45061631
24PBK1.38280126
25CSNK1G11.37720930
26SRPK11.34754340
27DYRK21.34463265
28CSNK1G31.33480467
29CSNK1G21.30697532
30PAK31.27374336
31MARK11.20830063
32PRKCE1.15195050
33DYRK31.13087596
34CSNK1A1L1.09591894
35OXSR11.08875550
36MUSK1.07072027
37VRK21.06900584
38BRSK21.05689720
39DAPK21.04189288
40PRKCG1.02439895
41PLK31.01339311
42PAK61.01025809
43PDK21.00023433
44MINK10.97670136
45CCNB10.95173522
46TNIK0.93172361
47LIMK10.92081096
48PLK20.87691950
49VRK10.82286222
50CDK30.82016718
51BCKDK0.81478536
52STK390.79333227
53TIE10.76535618
54NME10.69607925
55FGFR20.69065222
56DAPK10.66809908
57IRAK20.66679512
58STK160.66455407
59LMTK20.64834806
60TLK10.63628760
61KIT0.63526464
62INSRR0.63275577
63MAP3K50.60517700
64TGFBR10.59507080
65CAMK2A0.58281241
66MAP2K60.56356467
67TAOK30.56030493
68PLK10.54891495
69MATK0.49078655
70WNK40.47889225
71FGR0.46554870
72RPS6KA50.46508143
73EPHA30.45391708
74FLT30.41043267
75OBSCN0.38211918
76FER0.38163895
77RPS6KA40.37903883
78DYRK1A0.37827498
79PKN10.37725361
80PRKACA0.37081429
81ATR0.36907563
82MAP2K40.36096310
83CSNK1D0.35537261
84CLK10.35371173
85ADRBK10.35031479
86CDK140.34989543
87MAP3K120.34237228
88TTK0.33477452
89TESK20.33356027
90PRKCA0.32941813
91CSNK1A10.32755310
92STK38L0.32661133
93ATM0.32175214
94MAPKAPK30.31386296
95STK30.29206564
96PRKDC0.28808281
97ABL10.26764329
98PHKG10.26381627
99PHKG20.26381627
100PRKCQ0.26123089

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.60424987
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.58287857
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55211189
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52674390
5Oxidative phosphorylation_Homo sapiens_hsa001902.45388143
6Protein export_Homo sapiens_hsa030602.38264846
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.22826245
8Regulation of autophagy_Homo sapiens_hsa041402.11616837
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07700622
10Phototransduction_Homo sapiens_hsa047442.00183563
11Butanoate metabolism_Homo sapiens_hsa006501.92621397
12Parkinsons disease_Homo sapiens_hsa050121.86467625
13Proteasome_Homo sapiens_hsa030501.85001430
14Fanconi anemia pathway_Homo sapiens_hsa034601.84478573
15Non-homologous end-joining_Homo sapiens_hsa034501.82074071
16Basal transcription factors_Homo sapiens_hsa030221.78395683
17Peroxisome_Homo sapiens_hsa041461.74885904
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74477438
19RNA polymerase_Homo sapiens_hsa030201.72971067
20Steroid biosynthesis_Homo sapiens_hsa001001.68026674
21Nicotine addiction_Homo sapiens_hsa050331.66122449
22Propanoate metabolism_Homo sapiens_hsa006401.64359267
23Collecting duct acid secretion_Homo sapiens_hsa049661.63859576
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60826537
25RNA degradation_Homo sapiens_hsa030181.57058457
26Ether lipid metabolism_Homo sapiens_hsa005651.55466877
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.48369520
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46649372
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46459889
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45571492
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45118861
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.42651490
33Linoleic acid metabolism_Homo sapiens_hsa005911.40958700
34Base excision repair_Homo sapiens_hsa034101.40270622
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32852603
36Homologous recombination_Homo sapiens_hsa034401.29912526
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27451723
38Fatty acid elongation_Homo sapiens_hsa000621.19375848
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11225136
40Huntingtons disease_Homo sapiens_hsa050161.09997345
41Taste transduction_Homo sapiens_hsa047421.09272413
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08808810
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07575106
44Chemical carcinogenesis_Homo sapiens_hsa052041.04175103
45Purine metabolism_Homo sapiens_hsa002301.03574083
46Tryptophan metabolism_Homo sapiens_hsa003801.01724640
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01058123
48Mismatch repair_Homo sapiens_hsa034301.01053501
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00001492
50Alzheimers disease_Homo sapiens_hsa050100.97164675
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96381708
52Glutathione metabolism_Homo sapiens_hsa004800.94160254
53Caffeine metabolism_Homo sapiens_hsa002320.93287359
54Pyrimidine metabolism_Homo sapiens_hsa002400.90714209
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90117522
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89103382
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.84957612
58GABAergic synapse_Homo sapiens_hsa047270.83288329
59Circadian entrainment_Homo sapiens_hsa047130.82778073
60Nitrogen metabolism_Homo sapiens_hsa009100.82152623
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82046760
62Cardiac muscle contraction_Homo sapiens_hsa042600.81596957
63Metabolic pathways_Homo sapiens_hsa011000.81152723
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80852258
65Fatty acid metabolism_Homo sapiens_hsa012120.77949374
66beta-Alanine metabolism_Homo sapiens_hsa004100.77698953
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.77403519
68Glutamatergic synapse_Homo sapiens_hsa047240.76353687
69Retinol metabolism_Homo sapiens_hsa008300.75264320
70Olfactory transduction_Homo sapiens_hsa047400.74581404
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74024667
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73943595
73Vitamin B6 metabolism_Homo sapiens_hsa007500.71795507
74RNA transport_Homo sapiens_hsa030130.69080585
75Arachidonic acid metabolism_Homo sapiens_hsa005900.66136042
76Type I diabetes mellitus_Homo sapiens_hsa049400.64413691
77Long-term depression_Homo sapiens_hsa047300.63633668
78Circadian rhythm_Homo sapiens_hsa047100.62209504
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61501969
80Synaptic vesicle cycle_Homo sapiens_hsa047210.58740334
81Rheumatoid arthritis_Homo sapiens_hsa053230.56810079
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55578930
83Oocyte meiosis_Homo sapiens_hsa041140.51994007
84Fat digestion and absorption_Homo sapiens_hsa049750.50925366
85Morphine addiction_Homo sapiens_hsa050320.50477257
86Pyruvate metabolism_Homo sapiens_hsa006200.50318099
87Asthma_Homo sapiens_hsa053100.50161384
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49957935
89Vitamin digestion and absorption_Homo sapiens_hsa049770.48799229
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48351129
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47867424
92Salivary secretion_Homo sapiens_hsa049700.47350820
93Serotonergic synapse_Homo sapiens_hsa047260.46970330
94Sphingolipid metabolism_Homo sapiens_hsa006000.44659855
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43882436
96Sulfur metabolism_Homo sapiens_hsa009200.43604193
97Nucleotide excision repair_Homo sapiens_hsa034200.40257522
98ABC transporters_Homo sapiens_hsa020100.38399549
99Folate biosynthesis_Homo sapiens_hsa007900.37754056
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.36338923

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »