ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.69507203
2	neuron fate determination (GO:0048664)	4.31379813
3	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	4.09881026
4	somite development (GO:0061053)	4.06002981
5	neurofilament cytoskeleton organization (GO:0060052)	3.98040609
6	positive regulation of amino acid transport (GO:0051957)	3.91126758
7	neurotransmitter catabolic process (GO:0042135)	3.81718330
8	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.76813590
9	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.71369305
10	protein localization to cilium (GO:0061512)	3.65302627
11	pyrimidine nucleobase catabolic process (GO:0006208)	3.63377461
12	indolalkylamine metabolic process (GO:0006586)	3.61717851
13	neuronal action potential (GO:0019228)	3.50998833
14	anterograde axon cargo transport (GO:0008089)	3.50515654
15	limb bud formation (GO:0060174)	3.49949728
16	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.49224158
17	fucose catabolic process (GO:0019317)	3.42389042
18	L-fucose metabolic process (GO:0042354)	3.42389042
19	L-fucose catabolic process (GO:0042355)	3.42389042
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.41835139
21	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.28837816
22	platelet dense granule organization (GO:0060155)	3.27995869
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23346094
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.23164201
25	hindbrain development (GO:0030902)	3.22838274
26	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.22703684
27	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.21963476
28	nucleobase catabolic process (GO:0046113)	3.19802035
29	adult feeding behavior (GO:0008343)	3.17995525
30	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.13268120
31	tryptophan metabolic process (GO:0006568)	3.13231666
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.11222420
33	NADH dehydrogenase complex assembly (GO:0010257)	3.11222420
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.11222420
35	sulfation (GO:0051923)	3.09703270
36	rRNA catabolic process (GO:0016075)	3.04841590
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.03819483
38	neuronal stem cell maintenance (GO:0097150)	3.02291626
39	protein complex biogenesis (GO:0070271)	3.00634962
40	regulation of microtubule-based movement (GO:0060632)	3.00282998
41	otic vesicle formation (GO:0030916)	3.00211416
42	kidney morphogenesis (GO:0060993)	2.98747023
43	retinal ganglion cell axon guidance (GO:0031290)	2.97124898
44	cilium organization (GO:0044782)	2.96404048
45	indole-containing compound catabolic process (GO:0042436)	2.95300586
46	indolalkylamine catabolic process (GO:0046218)	2.95300586
47	tryptophan catabolic process (GO:0006569)	2.95300586
48	positive regulation of cellular response to oxidative stress (GO:1900409)	2.94772382
49	positive regulation of response to oxidative stress (GO:1902884)	2.94772382
50	cilium or flagellum-dependent cell motility (GO:0001539)	2.94300334
51	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.92635818
52	phenylpropanoid metabolic process (GO:0009698)	2.92477912
53	spinal cord motor neuron differentiation (GO:0021522)	2.88714490
54	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.86875953
55	forebrain neuron differentiation (GO:0021879)	2.85382376
56	multicellular organism reproduction (GO:0032504)	2.83720567
57	cilium assembly (GO:0042384)	2.81876378
58	ATP synthesis coupled proton transport (GO:0015986)	2.81600020
59	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.81600020
60	negative regulation of mast cell activation (GO:0033004)	2.81396287
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.80839195
62	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.80690348
63	nephron epithelium morphogenesis (GO:0072088)	2.80491310
64	nephron tubule morphogenesis (GO:0072078)	2.80491310
65	neurotransmitter metabolic process (GO:0042133)	2.80181660
66	replication fork processing (GO:0031297)	2.79793858
67	synaptic transmission, cholinergic (GO:0007271)	2.77282859
68	indole-containing compound metabolic process (GO:0042430)	2.76676504
69	DNA deamination (GO:0045006)	2.76632463
70	negative regulation of interleukin-1 beta production (GO:0032691)	2.76354305
71	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.75698787
72	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.75698787
73	protein-cofactor linkage (GO:0018065)	2.75427194
74	piRNA metabolic process (GO:0034587)	2.74752179
75	regulation of cilium movement (GO:0003352)	2.74706583
76	epithelial cilium movement (GO:0003351)	2.73470722
77	nonmotile primary cilium assembly (GO:0035058)	2.73435537
78	protein localization to microtubule cytoskeleton (GO:0072698)	2.72712398
79	axonemal dynein complex assembly (GO:0070286)	2.72679014
80	inner ear receptor stereocilium organization (GO:0060122)	2.68626891
81	cellular ketone body metabolic process (GO:0046950)	2.68105657
82	negative regulation of telomere maintenance (GO:0032205)	2.68072817
83	protein localization to cytoskeleton (GO:0044380)	2.66001343
84	kynurenine metabolic process (GO:0070189)	2.65246252
85	regulation of glucokinase activity (GO:0033131)	2.64579475
86	regulation of hexokinase activity (GO:1903299)	2.64579475
87	neural tube formation (GO:0001841)	2.64289051
88	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.64158449
89	central nervous system myelination (GO:0022010)	2.63382747
90	axon ensheathment in central nervous system (GO:0032291)	2.63382747
91	renal tubule morphogenesis (GO:0061333)	2.62412274
92	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.60471501
93	positive regulation of gastrulation (GO:2000543)	2.60246143
94	protein polyglutamylation (GO:0018095)	2.59139101
95	retinal cone cell development (GO:0046549)	2.56774000
96	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.54715575
97	NAD biosynthetic process (GO:0009435)	2.53970033
98	serotonin metabolic process (GO:0042428)	2.53216084
99	neuronal action potential propagation (GO:0019227)	2.52758398
100	cilium movement (GO:0003341)	2.52032852

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.69143412
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.65718372
3	VDR_22108803_ChIP-Seq_LS180_Human	3.48428850
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.26672951
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72236196
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.71209334
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.64199674
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48104414
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34718486
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.31601176
11	FUS_26573619_Chip-Seq_HEK293_Human	2.29324800
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12689614
13	EWS_26573619_Chip-Seq_HEK293_Human	2.12377687
14	AR_21572438_ChIP-Seq_LNCaP_Human	2.08082078
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.07108028
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04986574
17	P300_19829295_ChIP-Seq_ESCs_Human	2.02211226
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00968912
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.97026717
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.93020682
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89247793
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.88675080
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.87419169
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.76050177
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.74588343
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73013702
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70363510
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67598839
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.65902229
30	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63877897
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63842134
32	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.63698283
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.63657635
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61945445
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59877018
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57223228
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55299151
38	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54958936
39	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.54692229
40	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.53003715
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51444224
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50279502
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.47998398
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47998398
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45734152
46	AR_25329375_ChIP-Seq_VCAP_Human	1.45590712
47	STAT3_23295773_ChIP-Seq_U87_Human	1.45225889
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.45203980
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.43523834
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43507217
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42890897
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42178136
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41267961
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37080824
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37072170
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34827311
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34556117
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33857075
59	REST_21632747_ChIP-Seq_MESCs_Mouse	1.31878187
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31092965
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.31092965
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.29777602
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.28614122
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28344937
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28344937
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26036939
67	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25863436
68	TCF4_23295773_ChIP-Seq_U87_Human	1.25202072
69	* MYC_18940864_ChIP-ChIP_HL60_Human	1.22531228
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21407571
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20771213
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20771213
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19602272
74	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.19156895
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18231440
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17605316
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.16318010
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15699717
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15388874
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14050062
81	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.13402083
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12354033
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11739073
84	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.09005745
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08759169
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08699375
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.06930242
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06225064
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06210231
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04554087
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04491538
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03582060
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01690917
94	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.01403124
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99800618
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98679466
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98306727
98	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98302445
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98052133
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98017821

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	3.06470845
2	MP0002735_abnormal_chemical_nociception	3.02170196
3	MP0008877_abnormal_DNA_methylation	2.51143588
4	MP0002736_abnormal_nociception_after	2.48988643
5	MP0002102_abnormal_ear_morphology	2.45539335
6	MP0000569_abnormal_digit_pigmentation	2.42861263
7	MP0006072_abnormal_retinal_apoptosis	2.41853052
8	MP0004133_heterotaxia	2.34528006
9	MP0003195_calcinosis	2.34288358
10	MP0003136_yellow_coat_color	2.32609770
11	MP0001968_abnormal_touch/_nociception	2.27879380
12	MP0004885_abnormal_endolymph	1.98369844
13	MP0005551_abnormal_eye_electrophysiolog	1.97212942
14	MP0005187_abnormal_penis_morphology	1.96912481
15	MP0002837_dystrophic_cardiac_calcinosis	1.96096213
16	MP0003283_abnormal_digestive_organ	1.90377980
17	MP0003787_abnormal_imprinting	1.88250418
18	MP0008872_abnormal_physiological_respon	1.87948068
19	MP0004142_abnormal_muscle_tone	1.82422613
20	MP0005646_abnormal_pituitary_gland	1.80022744
21	MP0002282_abnormal_trachea_morphology	1.79211696
22	MP0009745_abnormal_behavioral_response	1.77221188
23	MP0008875_abnormal_xenobiotic_pharmacok	1.74804983
24	MP0005253_abnormal_eye_physiology	1.74779019
25	MP0002938_white_spotting	1.74057358
26	MP0002272_abnormal_nervous_system	1.68664514
27	MP0000631_abnormal_neuroendocrine_gland	1.68284463
28	MP0001485_abnormal_pinna_reflex	1.63477225
29	MP0002653_abnormal_ependyma_morphology	1.62357352
30	MP0003011_delayed_dark_adaptation	1.60106403
31	MP0010386_abnormal_urinary_bladder	1.56894354
32	MP0001984_abnormal_olfaction	1.55950939
33	MP0006292_abnormal_olfactory_placode	1.53622593
34	MP0008995_early_reproductive_senescence	1.53059150
35	MP0001486_abnormal_startle_reflex	1.51981017
36	MP0001970_abnormal_pain_threshold	1.48726158
37	MP0008058_abnormal_DNA_repair	1.48466426
38	MP0002876_abnormal_thyroid_physiology	1.45560860
39	MP0004742_abnormal_vestibular_system	1.45456851
40	MP0001529_abnormal_vocalization	1.41610770
41	MP0000372_irregular_coat_pigmentation	1.41043088
42	MP0004147_increased_porphyrin_level	1.40958416
43	MP0002557_abnormal_social/conspecific_i	1.40740699
44	MP0000427_abnormal_hair_cycle	1.38396355
45	MP0001986_abnormal_taste_sensitivity	1.37751807
46	MP0009046_muscle_twitch	1.37357436
47	MP0000778_abnormal_nervous_system	1.36200520
48	MP0002064_seizures	1.35862082
49	MP0002928_abnormal_bile_duct	1.35584876
50	MP0005084_abnormal_gallbladder_morpholo	1.35256649
51	MP0002572_abnormal_emotion/affect_behav	1.34864395
52	MP0000538_abnormal_urinary_bladder	1.33003207
53	MP0005379_endocrine/exocrine_gland_phen	1.31234488
54	MP0003890_abnormal_embryonic-extraembry	1.29328519
55	MP0003880_abnormal_central_pattern	1.26435392
56	MP0000383_abnormal_hair_follicle	1.24091660
57	MP0003119_abnormal_digestive_system	1.23447614
58	MP0002163_abnormal_gland_morphology	1.22488396
59	MP0000647_abnormal_sebaceous_gland	1.20792454
60	MP0002277_abnormal_respiratory_mucosa	1.17449962
61	MP0005171_absent_coat_pigmentation	1.16279902
62	MP0002160_abnormal_reproductive_system	1.14765612
63	MP0000049_abnormal_middle_ear	1.14470175
64	MP0002067_abnormal_sensory_capabilities	1.13200742
65	MP0001293_anophthalmia	1.09431282
66	MP0003718_maternal_effect	1.08928464
67	MP0000026_abnormal_inner_ear	1.07796038
68	MP0005195_abnormal_posterior_eye	1.05964410
69	MP0002234_abnormal_pharynx_morphology	1.05760638
70	MP0005389_reproductive_system_phenotype	1.05382240
71	MP0001501_abnormal_sleep_pattern	1.03607440
72	MP0002733_abnormal_thermal_nociception	1.03573328
73	MP0006276_abnormal_autonomic_nervous	1.02616712
74	MP0003635_abnormal_synaptic_transmissio	1.02548562
75	MP0003646_muscle_fatigue	1.00587084
76	MP0004924_abnormal_behavior	1.00253794
77	MP0005386_behavior/neurological_phenoty	1.00253794
78	MP0003315_abnormal_perineum_morphology	0.99326081
79	MP0001929_abnormal_gametogenesis	0.96961314
80	MP0002734_abnormal_mechanical_nocicepti	0.96603340
81	MP0002751_abnormal_autonomic_nervous	0.96591180
82	MP0002063_abnormal_learning/memory/cond	0.96004728
83	MP0003698_abnormal_male_reproductive	0.92022766
84	MP0005391_vision/eye_phenotype	0.90191285
85	MP0001963_abnormal_hearing_physiology	0.86516665
86	MP0004145_abnormal_muscle_electrophysio	0.86063643
87	MP0004215_abnormal_myocardial_fiber	0.85171588
88	MP0003937_abnormal_limbs/digits/tail_de	0.84820510
89	MP0001286_abnormal_eye_development	0.83494754
90	MP0002752_abnormal_somatic_nervous	0.82847171
91	MP0001919_abnormal_reproductive_system	0.82344995
92	MP0000955_abnormal_spinal_cord	0.81725273
93	MP0002822_catalepsy	0.81691525
94	MP0005220_abnormal_exocrine_pancreas	0.81033666
95	MP0005503_abnormal_tendon_morphology	0.80406220
96	MP0009384_cardiac_valve_regurgitation	0.79614690
97	MP0002095_abnormal_skin_pigmentation	0.77152696
98	MP0001905_abnormal_dopamine_level	0.76775442
99	MP0002693_abnormal_pancreas_physiology	0.76140630
100	MP0001944_abnormal_pancreas_morphology	0.75999263

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ulnar claw (HP:0001178)	4.69895661
2	True hermaphroditism (HP:0010459)	4.69636753
3	Type II lissencephaly (HP:0007260)	4.36988862
4	Pancreatic cysts (HP:0001737)	4.29126713
5	Pancreatic fibrosis (HP:0100732)	4.11475770
6	Molar tooth sign on MRI (HP:0002419)	3.88698800
7	Abnormality of midbrain morphology (HP:0002418)	3.88698800
8	Chronic hepatic failure (HP:0100626)	3.79386279
9	Nephronophthisis (HP:0000090)	3.55881997
10	Medial flaring of the eyebrow (HP:0010747)	3.45398562
11	Tubular atrophy (HP:0000092)	3.36584585
12	Cerebellar dysplasia (HP:0007033)	3.27146936
13	Abnormality of the renal cortex (HP:0011035)	3.02169081
14	Abnormality of the renal medulla (HP:0100957)	3.01084392
15	Bilateral microphthalmos (HP:0007633)	2.96730290
16	Pendular nystagmus (HP:0012043)	2.95185371
17	Congenital stationary night blindness (HP:0007642)	2.87855896
18	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.83361327
19	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.83361327
20	Volvulus (HP:0002580)	2.81369213
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.79712162
22	Abnormality of alanine metabolism (HP:0010916)	2.79712162
23	Hyperalaninemia (HP:0003348)	2.79712162
24	Cystic liver disease (HP:0006706)	2.78233457
25	Gait imbalance (HP:0002141)	2.74931171
26	Genetic anticipation (HP:0003743)	2.70949562
27	Congenital primary aphakia (HP:0007707)	2.70708145
28	Hyperventilation (HP:0002883)	2.69212989
29	Progressive inability to walk (HP:0002505)	2.67494590
30	Absent/shortened dynein arms (HP:0200106)	2.60956836
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.60956836
32	Bile duct proliferation (HP:0001408)	2.58631343
33	Abnormal biliary tract physiology (HP:0012439)	2.58631343
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.53491588
35	Birth length less than 3rd percentile (HP:0003561)	2.53437846
36	Retinal dysplasia (HP:0007973)	2.52393576
37	Hypothermia (HP:0002045)	2.51322962
38	Focal motor seizures (HP:0011153)	2.50794805
39	Abnormal respiratory epithelium morphology (HP:0012253)	2.49858523
40	Abnormal respiratory motile cilium morphology (HP:0005938)	2.49858523
41	Sclerocornea (HP:0000647)	2.47829964
42	Attenuation of retinal blood vessels (HP:0007843)	2.46965542
43	Abnormal ciliary motility (HP:0012262)	2.46928199
44	Male pseudohermaphroditism (HP:0000037)	2.44419625
45	Anencephaly (HP:0002323)	2.43380089
46	3-Methylglutaconic aciduria (HP:0003535)	2.41838709
47	Severe muscular hypotonia (HP:0006829)	2.41648888
48	Lissencephaly (HP:0001339)	2.41608385
49	Nephrogenic diabetes insipidus (HP:0009806)	2.41543994
50	Genital tract atresia (HP:0001827)	2.39678198
51	Large for gestational age (HP:0001520)	2.37387466
52	Inability to walk (HP:0002540)	2.36093973
53	Intestinal atresia (HP:0011100)	2.34466962
54	Renal cortical cysts (HP:0000803)	2.33037391
55	Chorioretinal atrophy (HP:0000533)	2.28285077
56	Optic nerve hypoplasia (HP:0000609)	2.28162954
57	Polydipsia (HP:0001959)	2.27458936
58	Abnormal drinking behavior (HP:0030082)	2.27458936
59	Vaginal atresia (HP:0000148)	2.24353984
60	Hypoplastic iliac wings (HP:0002866)	2.21818587
61	Atonic seizures (HP:0010819)	2.20534762
62	Absent speech (HP:0001344)	2.18477245
63	Concave nail (HP:0001598)	2.18416059
64	Occipital encephalocele (HP:0002085)	2.17380891
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.15538745
66	Congenital hepatic fibrosis (HP:0002612)	2.13641610
67	Abolished electroretinogram (ERG) (HP:0000550)	2.13312519
68	Keratoconus (HP:0000563)	2.10829382
69	Increased corneal curvature (HP:0100692)	2.10829382
70	Morphological abnormality of the pyramidal tract (HP:0002062)	2.09047294
71	Gastrointestinal atresia (HP:0002589)	2.07230062
72	Abnormal respiratory motile cilium physiology (HP:0012261)	2.02568197
73	Acute necrotizing encephalopathy (HP:0006965)	1.99683475
74	Hypoplasia of the pons (HP:0012110)	1.98819080
75	Optic disc pallor (HP:0000543)	1.98175891
76	Furrowed tongue (HP:0000221)	1.97613059
77	Abnormality of the pons (HP:0007361)	1.96960509
78	Abnormality of the corticospinal tract (HP:0002492)	1.94394049
79	Pachygyria (HP:0001302)	1.94311564
80	Protruding tongue (HP:0010808)	1.90721687
81	Poor coordination (HP:0002370)	1.87673257
82	Increased CSF lactate (HP:0002490)	1.87462930
83	Polyuria (HP:0000103)	1.87000495
84	Progressive cerebellar ataxia (HP:0002073)	1.86040195
85	Acute encephalopathy (HP:0006846)	1.85103549
86	Postaxial foot polydactyly (HP:0001830)	1.83308716
87	Congenital, generalized hypertrichosis (HP:0004540)	1.82095092
88	Partial agenesis of the corpus callosum (HP:0001338)	1.81254197
89	Long nose (HP:0003189)	1.80547736
90	Segmental peripheral demyelination/remyelination (HP:0003481)	1.79397690
91	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.79097572
92	Anophthalmia (HP:0000528)	1.76299429
93	Postaxial hand polydactyly (HP:0001162)	1.76298752
94	Dandy-Walker malformation (HP:0001305)	1.76107630
95	Patellar aplasia (HP:0006443)	1.74670831
96	Morphological abnormality of the middle ear (HP:0008609)	1.74160875
97	Mitochondrial inheritance (HP:0001427)	1.72288155
98	Stomach cancer (HP:0012126)	1.71778019
99	Febrile seizures (HP:0002373)	1.70822751
100	Small hand (HP:0200055)	1.70278513

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.05932082
2	PNCK	3.80686496
3	TSSK6	3.15697323
4	IRAK1	3.05870065
5	BMPR1B	3.04592319
6	INSRR	3.03787647
7	ACVR1B	2.95612249
8	ADRBK2	2.74700858
9	WNK3	2.42866625
10	MAP4K2	2.35099509
11	CASK	2.31003124
12	WEE1	2.28425783
13	GRK1	2.06315445
14	ZAK	1.92508797
15	MAPK15	1.88045210
16	MARK1	1.84960865
17	NUAK1	1.72290802
18	MAPK13	1.62376464
19	VRK1	1.62203767
20	MKNK2	1.59939665
21	TLK1	1.57736975
22	TIE1	1.47033305
23	PINK1	1.41412739
24	MAP3K4	1.41145598
25	TAOK3	1.39273110
26	TGFBR1	1.37879366
27	WNK4	1.37655027
28	EPHA3	1.29873773
29	DAPK2	1.29073181
30	DYRK3	1.22810105
31	PRKCG	1.20465037
32	ADRBK1	1.20058323
33	BRSK2	1.13913355
34	STK11	1.12248721
35	MUSK	1.09554819
36	CDK3	1.08726194
37	DYRK2	1.05660968
38	PLK3	1.02434140
39	MKNK1	1.00304178
40	CAMKK2	0.90281946
41	PAK3	0.88286431
42	TNIK	0.87760020
43	OXSR1	0.86672520
44	KIT	0.85279716
45	PRKCE	0.84502359
46	PTK2B	0.83647025
47	STK39	0.83028421
48	MAP2K7	0.81774323
49	MAPKAPK5	0.79226328
50	PIK3CA	0.75131991
51	PLK2	0.74505508
52	ERBB3	0.72797432
53	MAPKAPK3	0.68105516
54	RPS6KA5	0.68068691
55	MST4	0.61125207
56	CAMK2A	0.60766961
57	TRIM28	0.59804337
58	UHMK1	0.58285745
59	ERBB2	0.57222832
60	FGFR2	0.56429049
61	PLK1	0.55669843
62	LATS1	0.55024268
63	PKN1	0.52231775
64	TXK	0.52051522
65	PRKACA	0.50919381
66	OBSCN	0.46518449
67	BCKDK	0.46467286
68	IKBKB	0.46419466
69	STK38L	0.45846544
70	VRK2	0.45239491
71	NTRK2	0.42520412
72	NME1	0.42372318
73	PHKG2	0.41894189
74	PHKG1	0.41894189
75	MAP2K1	0.41867918
76	PRKAA1	0.41234835
77	PRKG1	0.41020281
78	CSNK1G2	0.40891979
79	PRKACB	0.40470612
80	CHUK	0.38356898
81	EIF2AK2	0.36819446
82	BUB1	0.36564607
83	SIK2	0.36485478
84	PRKCQ	0.34935645
85	NEK2	0.34863182
86	PRKCA	0.34329647
87	PRKCZ	0.31911831
88	PLK4	0.31843672
89	EPHA4	0.31813530
90	MELK	0.31441791
91	TEC	0.30871880
92	BCR	0.30579973
93	RPS6KB1	0.29835180
94	CSF1R	0.29675848
95	GRK7	0.28585272
96	ATR	0.28458799
97	STK3	0.28046302
98	CSNK1G1	0.27182165
99	ATM	0.26719503
100	PRKCH	0.25898672

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.93060703
2	Butanoate metabolism_Homo sapiens_hsa00650	2.87481409
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.82085442
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58339728
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.56816138
6	Phototransduction_Homo sapiens_hsa04744	2.55249680
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.53968945
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.32913569
9	Nicotine addiction_Homo sapiens_hsa05033	2.30088872
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.28879089
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.24213358
12	Protein export_Homo sapiens_hsa03060	2.17733932
13	Ether lipid metabolism_Homo sapiens_hsa00565	2.14291610
14	RNA polymerase_Homo sapiens_hsa03020	2.13108326
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.10767501
16	Parkinsons disease_Homo sapiens_hsa05012	2.02332941
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.99082961
18	Basal transcription factors_Homo sapiens_hsa03022	1.84378819
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77554392
20	Taste transduction_Homo sapiens_hsa04742	1.73433581
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72442788
22	Caffeine metabolism_Homo sapiens_hsa00232	1.64959023
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.62398940
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61145706
25	Huntingtons disease_Homo sapiens_hsa05016	1.54551647
26	Homologous recombination_Homo sapiens_hsa03440	1.52267684
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.44954221
28	Alzheimers disease_Homo sapiens_hsa05010	1.41595723
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33641579
30	Morphine addiction_Homo sapiens_hsa05032	1.32375091
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.31410182
32	RNA degradation_Homo sapiens_hsa03018	1.26382408
33	GABAergic synapse_Homo sapiens_hsa04727	1.24799017
34	Olfactory transduction_Homo sapiens_hsa04740	1.23030170
35	Glutamatergic synapse_Homo sapiens_hsa04724	1.16546696
36	Circadian entrainment_Homo sapiens_hsa04713	1.15361225
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14983528
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11156694
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08474889
40	Serotonergic synapse_Homo sapiens_hsa04726	1.02160917
41	Propanoate metabolism_Homo sapiens_hsa00640	1.01915658
42	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98915582
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.97013612
44	Peroxisome_Homo sapiens_hsa04146	0.95326162
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95075347
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93498945
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92260354
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89967753
49	Proteasome_Homo sapiens_hsa03050	0.88757495
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.88111592
51	ABC transporters_Homo sapiens_hsa02010	0.86699044
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84880857
53	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.84688147
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84648459
55	Insulin secretion_Homo sapiens_hsa04911	0.82330440
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.79321242
57	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77369112
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77168563
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.75590549
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72875843
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71330245
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68895138
63	Circadian rhythm_Homo sapiens_hsa04710	0.67706855
64	Regulation of autophagy_Homo sapiens_hsa04140	0.65979445
65	Retinol metabolism_Homo sapiens_hsa00830	0.64599845
66	One carbon pool by folate_Homo sapiens_hsa00670	0.64593165
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.63913565
68	Asthma_Homo sapiens_hsa05310	0.61338049
69	Purine metabolism_Homo sapiens_hsa00230	0.60129409
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.59954876
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.59137852
72	Histidine metabolism_Homo sapiens_hsa00340	0.58725196
73	Cocaine addiction_Homo sapiens_hsa05030	0.58042903
74	Salivary secretion_Homo sapiens_hsa04970	0.53349824
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.51560978
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51461393
77	Metabolic pathways_Homo sapiens_hsa01100	0.51457575
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50597129
79	Cholinergic synapse_Homo sapiens_hsa04725	0.47823888
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47553820
81	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.47023170
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.45835982
83	Non-homologous end-joining_Homo sapiens_hsa03450	0.45078076
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44582287
85	Mineral absorption_Homo sapiens_hsa04978	0.43249883
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.42501566
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42178252
88	Amphetamine addiction_Homo sapiens_hsa05031	0.40567501
89	Long-term depression_Homo sapiens_hsa04730	0.39940406
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.34774531
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.33787178
92	Ribosome_Homo sapiens_hsa03010	0.32010313
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31842185
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30465745
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.28881542
96	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27600223
97	Cell cycle_Homo sapiens_hsa04110	0.25926260
98	Oocyte meiosis_Homo sapiens_hsa04114	0.25817025
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.25460708
100	Axon guidance_Homo sapiens_hsa04360	0.25352498

ZNF225

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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