ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.38705947
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.11623543
3	behavioral response to nicotine (GO:0035095)	3.99835355
4	gamma-aminobutyric acid transport (GO:0015812)	3.93745871
5	nonmotile primary cilium assembly (GO:0035058)	3.90986483
6	epithelial cilium movement (GO:0003351)	3.84117054
7	presynaptic membrane assembly (GO:0097105)	3.67067754
8	regulation of cilium movement (GO:0003352)	3.60458083
9	protein polyglutamylation (GO:0018095)	3.55753964
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.55545279
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54539854
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54539854
13	NADH dehydrogenase complex assembly (GO:0010257)	3.54539854
14	neural tube formation (GO:0001841)	3.50911199
15	positive regulation of mitochondrial fission (GO:0090141)	3.46848190
16	protein complex biogenesis (GO:0070271)	3.43311950
17	cilium morphogenesis (GO:0060271)	3.37720195
18	nucleobase catabolic process (GO:0046113)	3.37550189
19	regulation of meiosis I (GO:0060631)	3.31873440
20	axoneme assembly (GO:0035082)	3.26332601
21	intraciliary transport (GO:0042073)	3.24802305
22	protein-cofactor linkage (GO:0018065)	3.20039448
23	histone H2A acetylation (GO:0043968)	3.18394442
24	presynaptic membrane organization (GO:0097090)	3.15167377
25	cilium movement (GO:0003341)	3.14549783
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.14422661
27	cilium organization (GO:0044782)	3.13286241
28	cilium assembly (GO:0042384)	3.06461212
29	DNA double-strand break processing (GO:0000729)	3.03934167
30	rRNA catabolic process (GO:0016075)	3.02215005
31	head development (GO:0060322)	3.00607756
32	anterograde synaptic vesicle transport (GO:0048490)	2.94752124
33	retinal ganglion cell axon guidance (GO:0031290)	2.94720746
34	auditory behavior (GO:0031223)	2.90676531
35	cell wall macromolecule catabolic process (GO:0016998)	2.90046344
36	replication fork processing (GO:0031297)	2.88913444
37	regulation of development, heterochronic (GO:0040034)	2.88313515
38	somite development (GO:0061053)	2.85432646
39	glycosphingolipid biosynthetic process (GO:0006688)	2.83383710
40	inositol phosphate catabolic process (GO:0071545)	2.83209635
41	regulation of timing of cell differentiation (GO:0048505)	2.81778074
42	transmission of nerve impulse (GO:0019226)	2.77383528
43	forebrain neuron differentiation (GO:0021879)	2.74067752
44	peptidyl-histidine modification (GO:0018202)	2.69199448
45	protein localization to cilium (GO:0061512)	2.68898478
46	ncRNA catabolic process (GO:0034661)	2.68695790
47	brain morphogenesis (GO:0048854)	2.62549956
48	L-fucose catabolic process (GO:0042355)	2.62193347
49	fucose catabolic process (GO:0019317)	2.62193347
50	L-fucose metabolic process (GO:0042354)	2.62193347
51	platelet dense granule organization (GO:0060155)	2.59333979
52	protein K11-linked deubiquitination (GO:0035871)	2.58376867
53	establishment of protein localization to Golgi (GO:0072600)	2.58116170
54	synapse assembly (GO:0007416)	2.57987715
55	startle response (GO:0001964)	2.57403657
56	centriole replication (GO:0007099)	2.57373293
57	olfactory bulb development (GO:0021772)	2.57173998
58	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.56939387
59	axonal fasciculation (GO:0007413)	2.56304929
60	mechanosensory behavior (GO:0007638)	2.54770326
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.53641167
62	spermatid nucleus differentiation (GO:0007289)	2.52757391
63	cullin deneddylation (GO:0010388)	2.52551769
64	pyrimidine dimer repair (GO:0006290)	2.51125806
65	DNA integration (GO:0015074)	2.50877202
66	respiratory chain complex IV assembly (GO:0008535)	2.49740178
67	photoreceptor cell maintenance (GO:0045494)	2.49506519
68	preassembly of GPI anchor in ER membrane (GO:0016254)	2.49327037
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.48857486
70	acrosome reaction (GO:0007340)	2.48612746
71	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.47789244
72	neuron cell-cell adhesion (GO:0007158)	2.47513242
73	protein prenylation (GO:0018342)	2.46554408
74	prenylation (GO:0097354)	2.46554408
75	inner ear receptor stereocilium organization (GO:0060122)	2.45693089
76	central nervous system projection neuron axonogenesis (GO:0021952)	2.45630574
77	regulation of mitochondrial fission (GO:0090140)	2.45354137
78	cellular component assembly involved in morphogenesis (GO:0010927)	2.44695161
79	resolution of meiotic recombination intermediates (GO:0000712)	2.43678708
80	postsynaptic membrane organization (GO:0001941)	2.43408748
81	behavioral response to ethanol (GO:0048149)	2.42722826
82	cerebral cortex radially oriented cell migration (GO:0021799)	2.42048701
83	limb bud formation (GO:0060174)	2.41455823
84	histone H2A ubiquitination (GO:0033522)	2.41349869
85	anterograde axon cargo transport (GO:0008089)	2.40766659
86	regulation of microtubule-based movement (GO:0060632)	2.40637919
87	negative regulation of mast cell activation (GO:0033004)	2.40211741
88	C4-dicarboxylate transport (GO:0015740)	2.39592659
89	regulation of DNA endoreduplication (GO:0032875)	2.39410099
90	water-soluble vitamin biosynthetic process (GO:0042364)	2.38881145
91	central nervous system neuron axonogenesis (GO:0021955)	2.38491139
92	regulation of hexokinase activity (GO:1903299)	2.37022400
93	regulation of glucokinase activity (GO:0033131)	2.37022400
94	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.36433547
95	cornea development in camera-type eye (GO:0061303)	2.36049113
96	GPI anchor metabolic process (GO:0006505)	2.35541744
97	neuron recognition (GO:0008038)	2.35365241
98	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.35269324
99	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.35225410
100	protein targeting to Golgi (GO:0000042)	2.35185706

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.56688668
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.21818976
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.17273751
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.98268392
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.84285712
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.80786360
7	VDR_22108803_ChIP-Seq_LS180_Human	2.65768593
8	FUS_26573619_Chip-Seq_HEK293_Human	2.64040657
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58541459
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51728790
11	* GABP_17652178_ChIP-ChIP_JURKAT_Human	2.42620694
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.42322272
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.34569786
14	* EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24880774
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.23246135
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.18397272
17	EWS_26573619_Chip-Seq_HEK293_Human	2.17401653
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15483469
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09107531
20	P300_19829295_ChIP-Seq_ESCs_Human	2.05122914
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.97375883
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96243269
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.93440309
24	* ELK1_19687146_ChIP-ChIP_HELA_Human	1.91776079
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87756709
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.82845804
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76598112
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74872656
29	* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.72199741
30	* MYC_18940864_ChIP-ChIP_HL60_Human	1.67962727
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65755067
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.64828032
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.62856519
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61471088
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59987799
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58269769
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.58269769
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56733094
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54076481
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52254696
41	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.51550806
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51393090
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51306882
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48908289
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47379285
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46914164
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43982149
48	STAT3_23295773_ChIP-Seq_U87_Human	1.42755164
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.42149726
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41234793
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39249706
52	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39229650
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.37479024
54	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.36298952
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35639595
56	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.34804522
57	AR_25329375_ChIP-Seq_VCAP_Human	1.34188672
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31895194
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29009715
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27973967
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27287916
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27287916
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26417528
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24912113
65	TCF4_23295773_ChIP-Seq_U87_Human	1.24605160
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24297239
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23382060
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21205007
69	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18552210
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17913797
71	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.17442428
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16137991
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15546907
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14798352
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14702907
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14429454
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14147380
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12889476
79	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.12382713
80	BCAT_22108803_ChIP-Seq_LS180_Human	1.12376042
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10909862
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.09474459
83	FOXP3_21729870_ChIP-Seq_TREG_Human	1.09342968
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07793515
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05343855
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05343855
87	TCF4_22108803_ChIP-Seq_LS180_Human	1.04377499
88	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.01665432
89	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01614414
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01289745
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99988969
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99441241
93	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99307638
94	AR_21572438_ChIP-Seq_LNCaP_Human	0.98731277
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98723359
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95854011
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94336793
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93723200
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93550070
100	JUN_21703547_ChIP-Seq_K562_Human	0.93093012

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.22618734
2	MP0003787_abnormal_imprinting	2.90970670
3	MP0008877_abnormal_DNA_methylation	2.61443215
4	MP0001986_abnormal_taste_sensitivity	2.40984673
5	MP0003880_abnormal_central_pattern	2.35526148
6	MP0001984_abnormal_olfaction	2.29284370
7	MP0003195_calcinosis	2.26650945
8	MP0005551_abnormal_eye_electrophysiolog	2.20353867
9	MP0006292_abnormal_olfactory_placode	2.19526520
10	MP0003136_yellow_coat_color	2.17829224
11	MP0000778_abnormal_nervous_system	2.11305303
12	MP0003121_genomic_imprinting	2.11190160
13	MP0008058_abnormal_DNA_repair	2.07569850
14	MP0004142_abnormal_muscle_tone	2.01868328
15	MP0003122_maternal_imprinting	1.96006920
16	MP0006072_abnormal_retinal_apoptosis	1.94855526
17	MP0001968_abnormal_touch/_nociception	1.93972015
18	MP0006276_abnormal_autonomic_nervous	1.93241807
19	MP0004147_increased_porphyrin_level	1.91940184
20	MP0005253_abnormal_eye_physiology	1.85077321
21	MP0009046_muscle_twitch	1.82870597
22	MP0002234_abnormal_pharynx_morphology	1.75162561
23	MP0008789_abnormal_olfactory_epithelium	1.74135191
24	MP0005394_taste/olfaction_phenotype	1.65828390
25	MP0005499_abnormal_olfactory_system	1.65828390
26	MP0002837_dystrophic_cardiac_calcinosis	1.62624198
27	MP0001486_abnormal_startle_reflex	1.60722805
28	MP0002638_abnormal_pupillary_reflex	1.60709007
29	MP0000372_irregular_coat_pigmentation	1.59885099
30	MP0004133_heterotaxia	1.59385343
31	MP0002653_abnormal_ependyma_morphology	1.58591059
32	MP0002736_abnormal_nociception_after	1.58474927
33	MP0002272_abnormal_nervous_system	1.58385847
34	MP0001529_abnormal_vocalization	1.58097571
35	MP0009745_abnormal_behavioral_response	1.54536215
36	MP0005423_abnormal_somatic_nervous	1.49191928
37	MP0002822_catalepsy	1.47505043
38	MP0005367_renal/urinary_system_phenotyp	1.47202884
39	MP0000516_abnormal_urinary_system	1.47202884
40	MP0002735_abnormal_chemical_nociception	1.46946590
41	MP0000631_abnormal_neuroendocrine_gland	1.44528382
42	MP0000569_abnormal_digit_pigmentation	1.41719283
43	MP0008995_early_reproductive_senescence	1.41673581
44	MP0005645_abnormal_hypothalamus_physiol	1.41407639
45	MP0000427_abnormal_hair_cycle	1.35272608
46	MP0003635_abnormal_synaptic_transmissio	1.33087894
47	MP0002572_abnormal_emotion/affect_behav	1.32809512
48	MP0002557_abnormal_social/conspecific_i	1.31251705
49	MP0001293_anophthalmia	1.30226361
50	MP0002938_white_spotting	1.27076113
51	MP0002064_seizures	1.24812628
52	MP0004043_abnormal_pH_regulation	1.24208008
53	MP0002751_abnormal_autonomic_nervous	1.23305555
54	MP0001188_hyperpigmentation	1.22059765
55	MP0004859_abnormal_synaptic_plasticity	1.20863102
56	MP0002067_abnormal_sensory_capabilities	1.19941845
57	MP0002734_abnormal_mechanical_nocicepti	1.16731813
58	MP0003937_abnormal_limbs/digits/tail_de	1.16084695
59	MP0005084_abnormal_gallbladder_morpholo	1.15771382
60	MP0002063_abnormal_learning/memory/cond	1.15443650
61	MP0005195_abnormal_posterior_eye	1.11223945
62	MP0002233_abnormal_nose_morphology	1.10232708
63	MP0002752_abnormal_somatic_nervous	1.10222705
64	MP0005391_vision/eye_phenotype	1.09408272
65	MP0006035_abnormal_mitochondrial_morpho	1.08736063
66	MP0003890_abnormal_embryonic-extraembry	1.08459228
67	MP0004924_abnormal_behavior	1.07207380
68	MP0005386_behavior/neurological_phenoty	1.07207380
69	MP0002882_abnormal_neuron_morphology	1.04638056
70	MP0004215_abnormal_myocardial_fiber	1.03356112
71	MP0002928_abnormal_bile_duct	1.02405353
72	MP0000955_abnormal_spinal_cord	1.02090878
73	MP0002095_abnormal_skin_pigmentation	1.01464344
74	MP0004811_abnormal_neuron_physiology	1.01093972
75	MP0003698_abnormal_male_reproductive	1.01088603
76	MP0002184_abnormal_innervation	0.99304030
77	MP0004885_abnormal_endolymph	0.97860176
78	MP0003718_maternal_effect	0.97411661
79	MP0010386_abnormal_urinary_bladder	0.97329224
80	MP0003119_abnormal_digestive_system	0.97178924
81	MP0008872_abnormal_physiological_respon	0.97047415
82	MP0000049_abnormal_middle_ear	0.96338829
83	MP0003567_abnormal_fetal_cardiomyocyte	0.93512596
84	MP0001324_abnormal_eye_pigmentation	0.92851938
85	MP0001970_abnormal_pain_threshold	0.92503752
86	MP0001929_abnormal_gametogenesis	0.92413224
87	MP0005379_endocrine/exocrine_gland_phen	0.90639293
88	MP0001270_distended_abdomen	0.90366160
89	MP0003011_delayed_dark_adaptation	0.89535536
90	MP0002210_abnormal_sex_determination	0.88408083
91	MP0005174_abnormal_tail_pigmentation	0.87831562
92	MP0000026_abnormal_inner_ear	0.86736068
93	MP0003938_abnormal_ear_development	0.86653234
94	MP0005187_abnormal_penis_morphology	0.86383106
95	MP0000647_abnormal_sebaceous_gland	0.85764006
96	MP0009697_abnormal_copulation	0.84759253
97	MP0002152_abnormal_brain_morphology	0.84000824
98	MP0004742_abnormal_vestibular_system	0.83742436
99	MP0001485_abnormal_pinna_reflex	0.83499370
100	MP0002733_abnormal_thermal_nociception	0.82931732

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.15603529
2	Abnormality of midbrain morphology (HP:0002418)	4.15603529
3	Medial flaring of the eyebrow (HP:0010747)	4.04545704
4	Pancreatic cysts (HP:0001737)	3.93224130
5	Chronic hepatic failure (HP:0100626)	3.78553958
6	Hyperventilation (HP:0002883)	3.75906927
7	Pancreatic fibrosis (HP:0100732)	3.63718712
8	Gait imbalance (HP:0002141)	3.53714503
9	Nephronophthisis (HP:0000090)	3.45201657
10	Congenital primary aphakia (HP:0007707)	3.43535304
11	True hermaphroditism (HP:0010459)	3.40995379
12	Nephrogenic diabetes insipidus (HP:0009806)	3.24416833
13	Genital tract atresia (HP:0001827)	3.05566820
14	Vaginal atresia (HP:0000148)	2.97422846
15	Abnormality of the renal medulla (HP:0100957)	2.80001588
16	Drooling (HP:0002307)	2.76818878
17	Abnormality of the labia minora (HP:0012880)	2.64575995
18	Excessive salivation (HP:0003781)	2.50998458
19	Poor coordination (HP:0002370)	2.48509793
20	Abnormality of the renal cortex (HP:0011035)	2.47038184
21	Acute necrotizing encephalopathy (HP:0006965)	2.45604592
22	Polyphagia (HP:0002591)	2.42516765
23	Methylmalonic acidemia (HP:0002912)	2.41148728
24	Retinal dysplasia (HP:0007973)	2.40360505
25	Broad-based gait (HP:0002136)	2.39972214
26	Mitochondrial inheritance (HP:0001427)	2.39185001
27	Absent speech (HP:0001344)	2.39002816
28	Type II lissencephaly (HP:0007260)	2.38324250
29	Lissencephaly (HP:0001339)	2.32078387
30	Postaxial hand polydactyly (HP:0001162)	2.29386733
31	Acute encephalopathy (HP:0006846)	2.26099253
32	Progressive macrocephaly (HP:0004481)	2.24149104
33	Increased CSF lactate (HP:0002490)	2.23680793
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21898584
35	Polydipsia (HP:0001959)	2.21545224
36	Abnormal drinking behavior (HP:0030082)	2.21545224
37	Volvulus (HP:0002580)	2.16051921
38	Tented upper lip vermilion (HP:0010804)	2.14768338
39	Narrow forehead (HP:0000341)	2.12555783
40	Cystic liver disease (HP:0006706)	2.11860751
41	Specific learning disability (HP:0001328)	2.11751281
42	Renal cortical cysts (HP:0000803)	2.11314673
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10407315
44	Congenital hepatic fibrosis (HP:0002612)	2.09701958
45	Lipid accumulation in hepatocytes (HP:0006561)	2.07683781
46	3-Methylglutaconic aciduria (HP:0003535)	2.07143646
47	Sclerocornea (HP:0000647)	2.05432708
48	Broad foot (HP:0001769)	2.05232183
49	Anencephaly (HP:0002323)	2.03301776
50	Bile duct proliferation (HP:0001408)	2.02449150
51	Abnormal biliary tract physiology (HP:0012439)	2.02449150
52	Dyskinesia (HP:0100660)	2.02120134
53	Progressive cerebellar ataxia (HP:0002073)	1.99719343
54	Congenital stationary night blindness (HP:0007642)	1.99422400
55	Prominent nasal bridge (HP:0000426)	1.99384678
56	Febrile seizures (HP:0002373)	1.98143937
57	Intestinal atresia (HP:0011100)	1.95740489
58	Amyotrophic lateral sclerosis (HP:0007354)	1.95277879
59	Occipital encephalocele (HP:0002085)	1.95055617
60	Protruding tongue (HP:0010808)	1.95053314
61	Colon cancer (HP:0003003)	1.94696147
62	Progressive inability to walk (HP:0002505)	1.94000327
63	Postaxial foot polydactyly (HP:0001830)	1.93757804
64	Increased hepatocellular lipid droplets (HP:0006565)	1.92986640
65	Hepatocellular necrosis (HP:0001404)	1.92965449
66	Decreased testicular size (HP:0008734)	1.91677950
67	Failure to thrive in infancy (HP:0001531)	1.91164395
68	Pachygyria (HP:0001302)	1.88801623
69	Pendular nystagmus (HP:0012043)	1.86660722
70	Tubular atrophy (HP:0000092)	1.85316390
71	Aplasia/Hypoplasia of the lens (HP:0008063)	1.84300712
72	Astigmatism (HP:0000483)	1.83636360
73	Optic nerve hypoplasia (HP:0000609)	1.83242009
74	Thyroid-stimulating hormone excess (HP:0002925)	1.83212918
75	Aganglionic megacolon (HP:0002251)	1.82948383
76	Oculomotor apraxia (HP:0000657)	1.82647081
77	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81869293
78	Tubulointerstitial nephritis (HP:0001970)	1.81628863
79	Methylmalonic aciduria (HP:0012120)	1.81541339
80	Hemiparesis (HP:0001269)	1.80573601
81	Male pseudohermaphroditism (HP:0000037)	1.80231849
82	Inability to walk (HP:0002540)	1.79925810
83	Widely spaced teeth (HP:0000687)	1.75329768
84	Hepatic necrosis (HP:0002605)	1.73596552
85	Gaze-evoked nystagmus (HP:0000640)	1.73176397
86	Hypothermia (HP:0002045)	1.72954535
87	Hyperglycinemia (HP:0002154)	1.72690523
88	Chorioretinal atrophy (HP:0000533)	1.72567270
89	Bifid tongue (HP:0010297)	1.71301638
90	Abnormality of macular pigmentation (HP:0008002)	1.71092743
91	Multicystic kidney dysplasia (HP:0000003)	1.70347460
92	Short foot (HP:0001773)	1.70161176
93	Optic disc pallor (HP:0000543)	1.69207602
94	Preaxial hand polydactyly (HP:0001177)	1.68637478
95	Atonic seizures (HP:0010819)	1.67940878
96	Micropenis (HP:0000054)	1.67749367
97	Neoplasm of the adrenal cortex (HP:0100641)	1.66541259
98	Focal motor seizures (HP:0011153)	1.66518795
99	Keratoconus (HP:0000563)	1.65880755
100	Increased corneal curvature (HP:0100692)	1.65880755

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.15800956
2	FRK	4.13457310
3	MAP3K4	2.90456812
4	BCR	2.70954621
5	MAPK13	2.43141079
6	MAP4K2	2.41740802
7	BMPR1B	2.21309762
8	MARK1	2.19468579
9	WNK3	2.07797162
10	TRIM28	2.04705740
11	MAP2K7	2.01685855
12	NUAK1	1.96419056
13	STK38L	1.94454699
14	ZAK	1.87802058
15	SRPK1	1.78844964
16	ACVR1B	1.77846533
17	EIF2AK3	1.75533420
18	PLK2	1.55517818
19	CDK19	1.53126138
20	MKNK2	1.47751213
21	GRK1	1.47280870
22	ERBB3	1.39765130
23	DYRK2	1.39086281
24	NTRK2	1.38839921
25	BCKDK	1.34724029
26	CSNK1G2	1.33645894
27	STK16	1.33089241
28	FGFR2	1.30153778
29	ADRBK2	1.29947985
30	EPHA4	1.27988911
31	PAK3	1.24683568
32	CSNK1G1	1.23298196
33	CSNK1G3	1.22860119
34	WNK4	1.20192898
35	CSNK1A1L	1.19097637
36	INSRR	1.17711197
37	EPHA3	1.13766123
38	OXSR1	1.12106954
39	PRKCG	1.07463505
40	STK39	1.06568759
41	TNIK	1.06204184
42	VRK1	1.02876546
43	MKNK1	1.02863207
44	PRKCE	1.02754222
45	BRD4	0.99303240
46	MAP2K4	0.95907300
47	PNCK	0.93625856
48	PINK1	0.93480325
49	DYRK3	0.92749652
50	DYRK1B	0.91361229
51	DYRK1A	0.86813101
52	RPS6KA4	0.85586207
53	MAPK15	0.77985268
54	TXK	0.77282706
55	NME1	0.77101224
56	TAOK3	0.74897790
57	PKN1	0.74204336
58	TLK1	0.67734185
59	CDK3	0.67172018
60	AKT3	0.66043643
61	TGFBR1	0.65519353
62	NTRK3	0.63295489
63	RPS6KA5	0.63275274
64	PLK3	0.63075661
65	MAP3K12	0.61882213
66	MATK	0.61660234
67	PRKACB	0.58153484
68	IRAK1	0.54852367
69	CAMK2A	0.54605953
70	ATM	0.52095454
71	CSNK1D	0.51777796
72	MINK1	0.51186501
73	FLT3	0.50761674
74	LATS1	0.49832616
75	PLK1	0.49375551
76	UHMK1	0.45268054
77	CSNK1A1	0.44722929
78	ADRBK1	0.44162947
79	CDC7	0.43336507
80	PRKACA	0.43067203
81	CAMK1	0.42905654
82	DAPK2	0.41416129
83	ATR	0.41094391
84	PTK2B	0.40594321
85	OBSCN	0.37316739
86	PRKCZ	0.36909304
87	PRKG1	0.36069467
88	CCNB1	0.35597491
89	CDK5	0.35388104
90	CHEK2	0.34422845
91	MAP3K5	0.34188080
92	PRKAA1	0.33776922
93	PLK4	0.32859095
94	GRK7	0.32200396
95	EIF2AK1	0.31568998
96	PRKDC	0.30343281
97	CSNK1E	0.30117443
98	PHKG2	0.29648038
99	PHKG1	0.29648038
100	CAMKK2	0.29229652

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.15877751
2	Nicotine addiction_Homo sapiens_hsa05033	3.04658024
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.83255205
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.62996263
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.61572879
6	Phototransduction_Homo sapiens_hsa04744	2.38764792
7	Parkinsons disease_Homo sapiens_hsa05012	2.30713911
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.28288305
9	RNA polymerase_Homo sapiens_hsa03020	2.26896870
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.18460329
11	Basal transcription factors_Homo sapiens_hsa03022	2.08862274
12	Butanoate metabolism_Homo sapiens_hsa00650	2.03841964
13	Propanoate metabolism_Homo sapiens_hsa00640	1.95998783
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.88387427
15	Homologous recombination_Homo sapiens_hsa03440	1.88130471
16	RNA degradation_Homo sapiens_hsa03018	1.75174459
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.73837989
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.67102917
19	Huntingtons disease_Homo sapiens_hsa05016	1.67062315
20	GABAergic synapse_Homo sapiens_hsa04727	1.62872422
21	Taste transduction_Homo sapiens_hsa04742	1.62233240
22	Regulation of autophagy_Homo sapiens_hsa04140	1.61443989
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59179513
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.58644099
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51974463
26	Peroxisome_Homo sapiens_hsa04146	1.45993678
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43707604
28	Morphine addiction_Homo sapiens_hsa05032	1.41654412
29	Alzheimers disease_Homo sapiens_hsa05010	1.40981144
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.37167955
31	RNA transport_Homo sapiens_hsa03013	1.36893354
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36530190
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27687888
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23441543
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.23208096
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22591418
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.19798926
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.19558686
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.15065831
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.13092989
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12378487
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.11912231
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.11597876
44	Cardiac muscle contraction_Homo sapiens_hsa04260	1.09976581
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06619196
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06417634
47	Circadian entrainment_Homo sapiens_hsa04713	1.02743925
48	Dopaminergic synapse_Homo sapiens_hsa04728	1.00153244
49	Circadian rhythm_Homo sapiens_hsa04710	0.99061991
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.96917729
51	Olfactory transduction_Homo sapiens_hsa04740	0.95792916
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95691613
53	Cocaine addiction_Homo sapiens_hsa05030	0.94102530
54	Spliceosome_Homo sapiens_hsa03040	0.93092101
55	Caffeine metabolism_Homo sapiens_hsa00232	0.91771556
56	Purine metabolism_Homo sapiens_hsa00230	0.90048088
57	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.89114290
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89087709
59	Proteasome_Homo sapiens_hsa03050	0.88677787
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87631546
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86528912
62	Base excision repair_Homo sapiens_hsa03410	0.86313658
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.84322000
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80806173
65	mRNA surveillance pathway_Homo sapiens_hsa03015	0.80378330
66	Mismatch repair_Homo sapiens_hsa03430	0.79928074
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.77482279
68	Sulfur metabolism_Homo sapiens_hsa00920	0.73709370
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73225245
70	Retinol metabolism_Homo sapiens_hsa00830	0.69393682
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69140949
72	Serotonergic synapse_Homo sapiens_hsa04726	0.68977659
73	Insulin secretion_Homo sapiens_hsa04911	0.68922280
74	Metabolic pathways_Homo sapiens_hsa01100	0.67675914
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67621637
76	Amphetamine addiction_Homo sapiens_hsa05031	0.66283539
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64246485
78	Axon guidance_Homo sapiens_hsa04360	0.57917535
79	ABC transporters_Homo sapiens_hsa02010	0.56000455
80	Oocyte meiosis_Homo sapiens_hsa04114	0.54851311
81	Fatty acid elongation_Homo sapiens_hsa00062	0.53374274
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51357761
83	Alcoholism_Homo sapiens_hsa05034	0.51101765
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.50476170
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.50169828
86	Long-term depression_Homo sapiens_hsa04730	0.46790115
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42113447
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.41671950
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40808223
90	DNA replication_Homo sapiens_hsa03030	0.40045439
91	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.36611744
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34214720
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32081973
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30960820
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30324006
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.29925155
97	Fatty acid degradation_Homo sapiens_hsa00071	0.29289299
98	Ribosome_Homo sapiens_hsa03010	0.28305425
99	Cholinergic synapse_Homo sapiens_hsa04725	0.24098335
100	Lysine degradation_Homo sapiens_hsa00310	0.22876186

ZNF226

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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