ZNF227

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein polyglutamylation (GO:0018095)5.19017711
2mitotic sister chromatid cohesion (GO:0007064)4.83461957
3regulation of meiosis I (GO:0060631)4.81035852
4spliceosomal tri-snRNP complex assembly (GO:0000244)4.70965692
5piRNA metabolic process (GO:0034587)4.41958621
6histone H2A acetylation (GO:0043968)4.35216139
7nuclear pore organization (GO:0006999)4.08172011
8negative regulation of fibroblast apoptotic process (GO:2000270)4.01651966
9mitotic metaphase plate congression (GO:0007080)3.91421822
10estrogen biosynthetic process (GO:0006703)3.87547053
11nuclear pore complex assembly (GO:0051292)3.86315263
12sister chromatid segregation (GO:0000819)3.76585235
13attachment of spindle microtubules to kinetochore (GO:0008608)3.74374523
14DNA synthesis involved in DNA repair (GO:0000731)3.72825274
15mitotic sister chromatid segregation (GO:0000070)3.55264016
16base-excision repair, AP site formation (GO:0006285)3.54051174
17replication fork processing (GO:0031297)3.53502060
18meiotic cell cycle (GO:0051321)3.50903346
19somatic hypermutation of immunoglobulin genes (GO:0016446)3.49479214
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.49479214
21synapsis (GO:0007129)3.48813927
22DNA damage response, detection of DNA damage (GO:0042769)3.45582527
23regulation of DNA endoreduplication (GO:0032875)3.42489809
24metaphase plate congression (GO:0051310)3.40081131
25sister chromatid cohesion (GO:0007062)3.38956556
26spindle checkpoint (GO:0031577)3.38257017
27gene silencing by RNA (GO:0031047)3.36958426
28protein localization to kinetochore (GO:0034501)3.33672171
29centriole replication (GO:0007099)3.31033784
30ribonucleoprotein complex disassembly (GO:0032988)3.30916769
31mitotic spindle checkpoint (GO:0071174)3.28332260
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21548904
33protein localization to chromosome, centromeric region (GO:0071459)3.21062644
34chromatin remodeling at centromere (GO:0031055)3.19923692
35DNA demethylation (GO:0080111)3.17966868
36negative regulation of chromosome segregation (GO:0051985)3.11449198
37meiotic chromosome segregation (GO:0045132)3.09687016
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.09285179
39CENP-A containing nucleosome assembly (GO:0034080)3.08472183
40negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01986933
41negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01986933
42negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01986933
43negative regulation of mitotic sister chromatid separation (GO:2000816)3.01986933
44negative regulation of sister chromatid segregation (GO:0033046)3.01986933
45mitotic spindle assembly checkpoint (GO:0007094)3.00092330
46axoneme assembly (GO:0035082)3.00063406
47resolution of meiotic recombination intermediates (GO:0000712)2.99107560
48spliceosomal snRNP assembly (GO:0000387)2.96702198
49spindle assembly checkpoint (GO:0071173)2.96357508
50regulation of chromatin binding (GO:0035561)2.96181311
51DNA methylation involved in gamete generation (GO:0043046)2.93838886
52histone mRNA catabolic process (GO:0071044)2.92800055
53regulation of mitotic sister chromatid separation (GO:0010965)2.92667973
54regulation of mitotic sister chromatid segregation (GO:0033047)2.92667973
55regulation of sister chromatid segregation (GO:0033045)2.92667973
56cullin deneddylation (GO:0010388)2.92202135
57neural tube formation (GO:0001841)2.90860612
58establishment of chromosome localization (GO:0051303)2.90226105
59negative regulation of DNA recombination (GO:0045910)2.89861906
60regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89599121
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89599121
62DNA dealkylation (GO:0035510)2.86509118
63DNA replication checkpoint (GO:0000076)2.85991990
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84934860
65regulation of DNA-dependent DNA replication (GO:0090329)2.84612533
66non-recombinational repair (GO:0000726)2.84501823
67double-strand break repair via nonhomologous end joining (GO:0006303)2.84501823
68regulation of double-strand break repair via homologous recombination (GO:0010569)2.84220089
69DNA replication-dependent nucleosome organization (GO:0034723)2.81466239
70DNA replication-dependent nucleosome assembly (GO:0006335)2.81466239
71microtubule anchoring (GO:0034453)2.81111164
72mismatch repair (GO:0006298)2.79606479
73formation of translation preinitiation complex (GO:0001731)2.78810053
74microtubule depolymerization (GO:0007019)2.77592066
75pore complex assembly (GO:0046931)2.76925758
76base-excision repair (GO:0006284)2.76780200
77protein deneddylation (GO:0000338)2.76337725
78histone exchange (GO:0043486)2.76166196
79maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75492319
80organelle disassembly (GO:1903008)2.75446381
81protein localization to chromosome (GO:0034502)2.74055233
82double-strand break repair via homologous recombination (GO:0000724)2.73228143
83recombinational repair (GO:0000725)2.73105444
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.71931903
85male meiosis (GO:0007140)2.70829648
86peptidyl-histidine modification (GO:0018202)2.68528717
87positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67102516
88positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67102516
89positive regulation of mitotic sister chromatid separation (GO:1901970)2.67102516
90histone mRNA metabolic process (GO:0008334)2.66984613
91negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.66840622
92mitotic nuclear envelope disassembly (GO:0007077)2.66133965
93pre-miRNA processing (GO:0031054)2.65194432
94histone-serine phosphorylation (GO:0035404)2.62392969
95response to X-ray (GO:0010165)2.61186574
96negative regulation of cell cycle G2/M phase transition (GO:1902750)2.61122798
97double-strand break repair (GO:0006302)2.61088733
98positive regulation of DNA repair (GO:0045739)2.60779884
99regulation of mitotic spindle checkpoint (GO:1903504)2.60475071
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60475071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.79887158
2E2F7_22180533_ChIP-Seq_HELA_Human4.18204398
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.70061509
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47909858
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.02384144
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87632027
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.86994360
8ZNF274_21170338_ChIP-Seq_K562_Hela2.85937913
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.83769442
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.78147610
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.70237848
12FUS_26573619_Chip-Seq_HEK293_Human2.67610296
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57721861
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54768688
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51771576
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38252471
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27977334
18IGF1R_20145208_ChIP-Seq_DFB_Human2.26472590
19VDR_22108803_ChIP-Seq_LS180_Human2.18817442
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17263658
21* VDR_23849224_ChIP-Seq_CD4+_Human2.14074500
22* EWS_26573619_Chip-Seq_HEK293_Human2.12404331
23TAF15_26573619_Chip-Seq_HEK293_Human2.07768907
24GBX2_23144817_ChIP-Seq_PC3_Human2.07710415
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05986326
26EZH2_22144423_ChIP-Seq_EOC_Human1.99189433
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97734400
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96808296
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94287496
30* ELK1_19687146_ChIP-ChIP_HELA_Human1.92637416
31* ETS1_20019798_ChIP-Seq_JURKAT_Human1.91352716
32FOXP3_21729870_ChIP-Seq_TREG_Human1.90434661
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89963336
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80648140
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74602444
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72279236
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70804186
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67609579
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65908137
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64873847
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64198948
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.56705438
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55961856
44GATA1_22025678_ChIP-Seq_K562_Human1.54393393
45MYC_18940864_ChIP-ChIP_HL60_Human1.50603582
46CIITA_25753668_ChIP-Seq_RAJI_Human1.42803073
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.42176818
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41934172
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40258799
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.36384633
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34771512
52TTF2_22483619_ChIP-Seq_HELA_Human1.33979713
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30778982
54IRF1_19129219_ChIP-ChIP_H3396_Human1.30676946
55P300_19829295_ChIP-Seq_ESCs_Human1.29027903
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27709786
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27559973
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25745899
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25488894
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23075471
61CBP_20019798_ChIP-Seq_JUKART_Human1.23075471
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22611184
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19244770
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17829630
65* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17196855
66ER_23166858_ChIP-Seq_MCF-7_Human1.16878647
67DCP1A_22483619_ChIP-Seq_HELA_Human1.14766432
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11546851
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11222776
70* GABP_19822575_ChIP-Seq_HepG2_Human1.08064285
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07600385
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04973570
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04077394
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03693161
75STAT3_23295773_ChIP-Seq_U87_Human1.02289128
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00878646
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00715714
78* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00521063
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00047344
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00047344
81SMAD4_21799915_ChIP-Seq_A2780_Human0.98907234
82TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97178527
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96979114
84FLI1_27457419_Chip-Seq_LIVER_Mouse0.96929661
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96323919
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96110113
87* SOX2_16153702_ChIP-ChIP_HESCs_Human0.95980043
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95784504
89MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95510869
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94629607
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93384504
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91184825
93TP53_22573176_ChIP-Seq_HFKS_Human0.91020370
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88710230
95KDM5A_27292631_Chip-Seq_BREAST_Human0.88464914
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.87843778
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.87278421
98RNF2_27304074_Chip-Seq_NSC_Mouse0.87202398
99XRN2_22483619_ChIP-Seq_HELA_Human0.85842193
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85354505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.27165704
2MP0008058_abnormal_DNA_repair4.07722900
3MP0010094_abnormal_chromosome_stability3.61754649
4MP0003693_abnormal_embryo_hatching3.29345322
5MP0008877_abnormal_DNA_methylation3.28309292
6MP0006292_abnormal_olfactory_placode3.11439014
7MP0003718_maternal_effect2.81117347
8MP0003111_abnormal_nucleus_morphology2.67754917
9MP0003077_abnormal_cell_cycle2.65227324
10MP0000569_abnormal_digit_pigmentation2.46952354
11MP0003890_abnormal_embryonic-extraembry2.44355585
12MP0003567_abnormal_fetal_cardiomyocyte2.37906953
13MP0003880_abnormal_central_pattern2.28811407
14MP0004957_abnormal_blastocyst_morpholog2.25318433
15MP0001293_anophthalmia2.14703770
16MP0003646_muscle_fatigue1.99738585
17MP0008789_abnormal_olfactory_epithelium1.89882515
18MP0008932_abnormal_embryonic_tissue1.87486708
19MP0002653_abnormal_ependyma_morphology1.85998729
20MP0002009_preneoplasia1.84271969
21MP0010307_abnormal_tumor_latency1.61651719
22MP0002102_abnormal_ear_morphology1.56884559
23MP0001929_abnormal_gametogenesis1.54388033
24MP0008995_early_reproductive_senescence1.53857854
25MP0002837_dystrophic_cardiac_calcinosis1.48797672
26MP0000631_abnormal_neuroendocrine_gland1.48641457
27MP0005394_taste/olfaction_phenotype1.43000193
28MP0005499_abnormal_olfactory_system1.43000193
29MP0002210_abnormal_sex_determination1.42609039
30MP0008007_abnormal_cellular_replicative1.39716901
31MP0003937_abnormal_limbs/digits/tail_de1.37450996
32MP0009697_abnormal_copulation1.35017517
33MP0005551_abnormal_eye_electrophysiolog1.28801242
34MP0001984_abnormal_olfaction1.27806589
35MP0000653_abnormal_sex_gland1.24685096
36MP0003221_abnormal_cardiomyocyte_apopto1.24625747
37MP0001145_abnormal_male_reproductive1.23499356
38MP0005187_abnormal_penis_morphology1.22947231
39MP0003787_abnormal_imprinting1.22252062
40MP0001324_abnormal_eye_pigmentation1.22113702
41MP0000778_abnormal_nervous_system1.20216427
42MP0001730_embryonic_growth_arrest1.18634582
43MP0001529_abnormal_vocalization1.15915923
44MP0002084_abnormal_developmental_patter1.11813466
45MP0000428_abnormal_craniofacial_morphol1.10574780
46MP0003121_genomic_imprinting1.10481788
47MP0003698_abnormal_male_reproductive1.10080049
48MP0001672_abnormal_embryogenesis/_devel1.08308587
49MP0005380_embryogenesis_phenotype1.08308587
50MP0001286_abnormal_eye_development1.07149701
51MP0000383_abnormal_hair_follicle1.05442435
52MP0000350_abnormal_cell_proliferation1.04356037
53MP0002751_abnormal_autonomic_nervous1.04158346
54MP0002938_white_spotting1.03836295
55MP0003136_yellow_coat_color1.02822161
56MP0004197_abnormal_fetal_growth/weight/1.01792063
57MP0002160_abnormal_reproductive_system1.00967004
58MP0002085_abnormal_embryonic_tissue1.00283855
59MP0001119_abnormal_female_reproductive0.99561925
60MP0000049_abnormal_middle_ear0.98971972
61MP0002233_abnormal_nose_morphology0.98830773
62MP0006072_abnormal_retinal_apoptosis0.98745157
63MP0005391_vision/eye_phenotype0.96776193
64MP0001986_abnormal_taste_sensitivity0.96055932
65MP0000465_gastrointestinal_hemorrhage0.95921159
66MP0003861_abnormal_nervous_system0.94742656
67MP0004133_heterotaxia0.94329536
68MP0005253_abnormal_eye_physiology0.93872936
69MP0002095_abnormal_skin_pigmentation0.93071099
70MP0005395_other_phenotype0.91509924
71MP0001697_abnormal_embryo_size0.90559084
72MP0009703_decreased_birth_body0.90290673
73MP0000313_abnormal_cell_death0.89853271
74MP0003786_premature_aging0.89629563
75MP0003984_embryonic_growth_retardation0.88960008
76MP0002736_abnormal_nociception_after0.87796588
77MP0001764_abnormal_homeostasis0.87605189
78MP0002092_abnormal_eye_morphology0.87538490
79MP0006035_abnormal_mitochondrial_morpho0.85759498
80MP0002088_abnormal_embryonic_growth/wei0.85656366
81MP0005646_abnormal_pituitary_gland0.84805909
82MP0003935_abnormal_craniofacial_develop0.83443888
83MP0003699_abnormal_female_reproductive0.83411149
84MP0002697_abnormal_eye_size0.81887014
85MP0002234_abnormal_pharynx_morphology0.81023995
86MP0004233_abnormal_muscle_weight0.79342469
87MP0004142_abnormal_muscle_tone0.79326332
88MP0002080_prenatal_lethality0.75412041
89MP0002161_abnormal_fertility/fecundity0.75160332
90MP0003119_abnormal_digestive_system0.73777886
91MP0006276_abnormal_autonomic_nervous0.72003300
92MP0001486_abnormal_startle_reflex0.71956783
93MP0002277_abnormal_respiratory_mucosa0.71236726
94MP0003943_abnormal_hepatobiliary_system0.70696973
95MP0005423_abnormal_somatic_nervous0.69998796
96MP0001968_abnormal_touch/_nociception0.69966407
97MP0000358_abnormal_cell_content/0.69744861
98MP0001177_atelectasis0.69741620
99MP0002138_abnormal_hepatobiliary_system0.69295926
100MP0000516_abnormal_urinary_system0.68236548

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)4.70178418
2Reduced antithrombin III activity (HP:0001976)3.87612365
3Abnormality of macular pigmentation (HP:0008002)3.82125568
4Chromsome breakage (HP:0040012)3.47817445
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47041451
6Medial flaring of the eyebrow (HP:0010747)3.35494374
7Congenital primary aphakia (HP:0007707)3.26441991
8Volvulus (HP:0002580)3.23326212
9Nephrogenic diabetes insipidus (HP:0009806)3.20456449
10Gait imbalance (HP:0002141)3.18091837
11Protruding tongue (HP:0010808)3.04228971
12Capillary hemangiomas (HP:0005306)2.99248244
13Central scotoma (HP:0000603)2.87949105
14Abnormal lung lobation (HP:0002101)2.84565775
15Vaginal atresia (HP:0000148)2.80353938
16Genital tract atresia (HP:0001827)2.79892526
17Colon cancer (HP:0003003)2.76647409
18Poor coordination (HP:0002370)2.75818594
19Abnormality of chromosome stability (HP:0003220)2.73339129
20Abnormality of the labia minora (HP:0012880)2.71593113
21Oligodactyly (hands) (HP:0001180)2.65744985
22Aplasia/Hypoplasia of the sternum (HP:0006714)2.58188764
23Aplasia/Hypoplasia of the tibia (HP:0005772)2.54373649
24Dyschromatopsia (HP:0007641)2.54219852
25Bifid tongue (HP:0010297)2.52559599
26Supernumerary spleens (HP:0009799)2.52247052
27Rhabdomyosarcoma (HP:0002859)2.48097668
28Papillary thyroid carcinoma (HP:0002895)2.42291204
29Ectopic kidney (HP:0000086)2.39634772
30Amyotrophic lateral sclerosis (HP:0007354)2.35833946
31Chronic hepatic failure (HP:0100626)2.33784383
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.33330206
33Sloping forehead (HP:0000340)2.33123048
34Short tibia (HP:0005736)2.26431687
35Molar tooth sign on MRI (HP:0002419)2.25534967
36Abnormality of midbrain morphology (HP:0002418)2.25534967
37Cortical dysplasia (HP:0002539)2.24905503
38Self-mutilation (HP:0000742)2.23796634
39Meckel diverticulum (HP:0002245)2.21578137
40Birth length less than 3rd percentile (HP:0003561)2.20172767
41Tubulointerstitial nephritis (HP:0001970)2.18312959
42Oligodactyly (HP:0012165)2.17394256
43Glioma (HP:0009733)2.16148870
44Proximal placement of thumb (HP:0009623)2.16104654
45Bile duct proliferation (HP:0001408)2.15245569
46Abnormal biliary tract physiology (HP:0012439)2.15245569
47Abnormality of the ileum (HP:0001549)2.14958449
48Abnormal protein glycosylation (HP:0012346)2.14484884
49Abnormal glycosylation (HP:0012345)2.14484884
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14484884
51Abnormal protein N-linked glycosylation (HP:0012347)2.14484884
52Abnormality of the phalanges of the hallux (HP:0010057)2.14110114
53Broad foot (HP:0001769)2.11339711
54Decreased testicular size (HP:0008734)2.10221222
55Scotoma (HP:0000575)2.09480218
56Nephroblastoma (Wilms tumor) (HP:0002667)2.09220842
57Midline defect of the nose (HP:0004122)2.08230768
58Medulloblastoma (HP:0002885)2.05880684
59Gonadotropin excess (HP:0000837)2.05038108
60Hip dysplasia (HP:0001385)2.03448090
61Pancreatic cysts (HP:0001737)2.03283870
62Neoplasm of striated muscle (HP:0009728)2.02634502
63Abnormality of the intrinsic pathway (HP:0010989)2.02151123
64Postaxial hand polydactyly (HP:0001162)2.00967285
65Embryonal renal neoplasm (HP:0011794)1.97218031
66True hermaphroditism (HP:0010459)1.97070906
67Preaxial hand polydactyly (HP:0001177)1.95856285
68Generalized hypotonia (HP:0001290)1.95696443
69Astigmatism (HP:0000483)1.92923074
70Abnormality of the preputium (HP:0100587)1.91954789
71Long clavicles (HP:0000890)1.91576650
72Optic nerve coloboma (HP:0000588)1.91029389
73Astrocytoma (HP:0009592)1.90035630
74Abnormality of the astrocytes (HP:0100707)1.90035630
75Stenosis of the external auditory canal (HP:0000402)1.88844497
76Micropenis (HP:0000054)1.86511002
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86343997
78Triphalangeal thumb (HP:0001199)1.86195062
79Abnormality of the columella (HP:0009929)1.85066924
80Thoracolumbar scoliosis (HP:0002944)1.84221240
81Carpal bone hypoplasia (HP:0001498)1.83434343
82Microretrognathia (HP:0000308)1.78440540
83Abnormality of DNA repair (HP:0003254)1.76848769
84Deviation of the thumb (HP:0009603)1.76108369
85Long eyelashes (HP:0000527)1.75391166
86Hypoplastic pelvis (HP:0008839)1.75344962
87Abnormality of the septum pellucidum (HP:0007375)1.75056686
88Pancreatic fibrosis (HP:0100732)1.74560909
89Prominent nasal bridge (HP:0000426)1.73538753
90Absent forearm bone (HP:0003953)1.73522476
91Aplasia involving forearm bones (HP:0009822)1.73522476
92Abnormality of cochlea (HP:0000375)1.72128726
93Absent radius (HP:0003974)1.71642193
94Median cleft lip (HP:0000161)1.70218046
95Specific learning disability (HP:0001328)1.70163733
96Duodenal stenosis (HP:0100867)1.69826567
97Small intestinal stenosis (HP:0012848)1.69826567
98Anencephaly (HP:0002323)1.68720284
99Truncal obesity (HP:0001956)1.68319972
100Aplasia/Hypoplasia of the lens (HP:0008063)1.64748343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.04104490
2TTK2.89249996
3PNCK2.62128741
4SRPK12.55419096
5NUAK12.47589314
6MAP3K42.31079536
7NEK12.30353731
8MKNK12.28681431
9MKNK22.20545713
10CDC72.15305234
11TRIM282.06547147
12BRSK22.04449898
13TSSK61.84582994
14PLK41.82241465
15BRD41.81460917
16ACVR1B1.77456459
17PBK1.73000254
18EIF2AK31.72090155
19DAPK21.71866085
20PLK31.69990814
21BUB11.69419088
22ZAK1.62977087
23FRK1.62539120
24WNK31.61852442
25ATR1.57320972
26BMPR1B1.56914589
27CDK191.56733106
28CAMK1G1.51638552
29WEE11.47057652
30NEK21.46406777
31TAF11.40380760
32EIF2AK11.39404903
33STK38L1.36983065
34CCNB11.31886414
35PLK11.28517629
36ERBB31.26114570
37CAMKK21.25457773
38RPS6KA41.22540618
39LATS11.21140064
40PINK11.20509821
41CHEK21.17366585
42ATM1.15598396
43NLK1.07825594
44CHEK11.04661998
45CSNK1G11.04353826
46CDK31.01692468
47BCR1.00543995
48STK40.97989717
49VRK10.94464611
50CSNK1G30.93206225
51DAPK10.92619125
52CDK60.92394166
53ERBB40.89858435
54AURKB0.87963899
55MAP2K70.86853136
56CSNK1A1L0.86794892
57MAPK130.84414944
58CSNK1G20.84042663
59BRAF0.80739377
60BRSK10.80595272
61MAP3K100.75449692
62PDK20.74620908
63PLK20.73434599
64DYRK30.72394429
65TIE10.72216887
66STK30.69231234
67CAMK1D0.69112348
68TXK0.68673645
69CDK20.66088511
70EPHA40.65154213
71PIM10.63157692
72STK160.62047208
73NEK90.61312161
74EIF2AK20.59863662
75CDK10.59801685
76MARK30.59427682
77TEC0.59074327
78IRAK10.59000430
79PKN10.56485720
80CASK0.55185872
81STK390.53421103
82MAPK100.53192693
83BCKDK0.53006676
84TAOK30.48537790
85RPS6KA50.46869118
86WNK10.46566771
87MAPKAPK50.45590877
88INSRR0.43088380
89MELK0.41946919
90IRAK40.41763779
91CDK120.41398163
92NEK60.39814669
93STK240.38079555
94DYRK1A0.36981835
95TGFBR10.36870920
96RAF10.36551775
97CLK10.35820155
98DAPK30.35813379
99CDK70.35341390
100AURKA0.33963759

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.01606637
2Base excision repair_Homo sapiens_hsa034103.33142216
3Selenocompound metabolism_Homo sapiens_hsa004503.30301836
4Basal transcription factors_Homo sapiens_hsa030223.30186440
5Mismatch repair_Homo sapiens_hsa034303.03769111
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99084761
7Homologous recombination_Homo sapiens_hsa034402.81548692
8Fanconi anemia pathway_Homo sapiens_hsa034602.81473228
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72222939
10DNA replication_Homo sapiens_hsa030302.71821454
11RNA transport_Homo sapiens_hsa030132.61578287
12RNA polymerase_Homo sapiens_hsa030202.58340042
13RNA degradation_Homo sapiens_hsa030182.55525600
14Cell cycle_Homo sapiens_hsa041102.50204318
15Spliceosome_Homo sapiens_hsa030402.33843033
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32947908
17Cysteine and methionine metabolism_Homo sapiens_hsa002702.20562432
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18483941
19Nucleotide excision repair_Homo sapiens_hsa034202.13883481
20Fatty acid elongation_Homo sapiens_hsa000622.07870100
21mRNA surveillance pathway_Homo sapiens_hsa030151.89374551
22Propanoate metabolism_Homo sapiens_hsa006401.82840121
23Pyrimidine metabolism_Homo sapiens_hsa002401.60567415
24Regulation of autophagy_Homo sapiens_hsa041401.47548137
25Oocyte meiosis_Homo sapiens_hsa041141.32138277
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25411465
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25267700
28One carbon pool by folate_Homo sapiens_hsa006701.25105990
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24786248
30Proteasome_Homo sapiens_hsa030501.23657034
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18818268
32Lysine degradation_Homo sapiens_hsa003101.16994750
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16637703
34Purine metabolism_Homo sapiens_hsa002301.15684464
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11767545
36p53 signaling pathway_Homo sapiens_hsa041151.05689162
37Caffeine metabolism_Homo sapiens_hsa002321.02960108
38Phototransduction_Homo sapiens_hsa047440.96951911
39Protein export_Homo sapiens_hsa030600.96718394
40Ribosome_Homo sapiens_hsa030100.93058144
41Ether lipid metabolism_Homo sapiens_hsa005650.92537455
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86428383
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82405152
44Dorso-ventral axis formation_Homo sapiens_hsa043200.79454670
45Butanoate metabolism_Homo sapiens_hsa006500.78445512
46Hedgehog signaling pathway_Homo sapiens_hsa043400.76647310
47Ovarian steroidogenesis_Homo sapiens_hsa049130.70333764
48Pyruvate metabolism_Homo sapiens_hsa006200.70144812
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.66178008
50N-Glycan biosynthesis_Homo sapiens_hsa005100.65105670
51Steroid biosynthesis_Homo sapiens_hsa001000.64427819
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62593058
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60426843
54Systemic lupus erythematosus_Homo sapiens_hsa053220.56173741
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.55654176
56Basal cell carcinoma_Homo sapiens_hsa052170.55407309
57Olfactory transduction_Homo sapiens_hsa047400.54997912
58Taste transduction_Homo sapiens_hsa047420.53641755
59Nicotine addiction_Homo sapiens_hsa050330.51009903
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48830223
61Huntingtons disease_Homo sapiens_hsa050160.48234039
62Peroxisome_Homo sapiens_hsa041460.47510784
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47256705
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43262719
65Epstein-Barr virus infection_Homo sapiens_hsa051690.42367210
66Biosynthesis of amino acids_Homo sapiens_hsa012300.41337471
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41203686
68Alcoholism_Homo sapiens_hsa050340.40542493
69Colorectal cancer_Homo sapiens_hsa052100.39597198
70TGF-beta signaling pathway_Homo sapiens_hsa043500.37174791
71Metabolic pathways_Homo sapiens_hsa011000.36956396
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36098737
73Melanoma_Homo sapiens_hsa052180.35572823
74MicroRNAs in cancer_Homo sapiens_hsa052060.35425613
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34613018
76Linoleic acid metabolism_Homo sapiens_hsa005910.32745765
77FoxO signaling pathway_Homo sapiens_hsa040680.31924926
78beta-Alanine metabolism_Homo sapiens_hsa004100.31733087
79Herpes simplex infection_Homo sapiens_hsa051680.29780528
80Circadian rhythm_Homo sapiens_hsa047100.29663006
81Prostate cancer_Homo sapiens_hsa052150.28196895
82Arginine and proline metabolism_Homo sapiens_hsa003300.27048275
83Wnt signaling pathway_Homo sapiens_hsa043100.26910629
84Long-term depression_Homo sapiens_hsa047300.26903707
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26649189
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.26195278
87Viral carcinogenesis_Homo sapiens_hsa052030.24697082
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19877909
89ABC transporters_Homo sapiens_hsa020100.18928184
90Hippo signaling pathway_Homo sapiens_hsa043900.18539855
91Carbon metabolism_Homo sapiens_hsa012000.17524998
92Nitrogen metabolism_Homo sapiens_hsa009100.16709853
93Sulfur relay system_Homo sapiens_hsa041220.13437701
94mTOR signaling pathway_Homo sapiens_hsa041500.10424439
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10312043
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.09705984
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09677988
98Measles_Homo sapiens_hsa051620.09676678
99Gap junction_Homo sapiens_hsa045400.09423935
100Fatty acid metabolism_Homo sapiens_hsa012120.08167844

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