ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lactate metabolic process (GO:0006089)	4.00921647
2	presynaptic membrane assembly (GO:0097105)	3.78612014
3	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.17720845
4	pyrimidine nucleobase catabolic process (GO:0006208)	3.10262341
5	presynaptic membrane organization (GO:0097090)	3.09232157
6	axonal fasciculation (GO:0007413)	3.09015148
7	neuron recognition (GO:0008038)	3.08549948
8	nonmotile primary cilium assembly (GO:0035058)	3.01060417
9	paraxial mesoderm development (GO:0048339)	2.68153409
10	negative regulation of gluconeogenesis (GO:0045721)	2.65840058
11	negative chemotaxis (GO:0050919)	2.61689491
12	cochlea development (GO:0090102)	2.59415985
13	postsynaptic membrane organization (GO:0001941)	2.55553924
14	cellular response to leptin stimulus (GO:0044320)	2.53721667
15	smooth muscle tissue development (GO:0048745)	2.52436764
16	neurotransmitter-gated ion channel clustering (GO:0072578)	2.50575561
17	regulation of acrosome reaction (GO:0060046)	2.48107086
18	establishment of tissue polarity (GO:0007164)	2.44579417
19	establishment of planar polarity (GO:0001736)	2.44579417
20	regulation of axon guidance (GO:1902667)	2.43629425
21	embryonic body morphogenesis (GO:0010172)	2.43518170
22	neuron cell-cell adhesion (GO:0007158)	2.38066738
23	auditory behavior (GO:0031223)	2.36714930
24	polarized epithelial cell differentiation (GO:0030859)	2.36576491
25	peristalsis (GO:0030432)	2.36317637
26	apical protein localization (GO:0045176)	2.32784518
27	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.31746227
28	positive regulation of glycolytic process (GO:0045821)	2.31545555
29	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.31451432
30	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.31414130
31	retinal cone cell development (GO:0046549)	2.31076482
32	ephrin receptor signaling pathway (GO:0048013)	2.31048858
33	cerebral cortex radially oriented cell migration (GO:0021799)	2.28204006
34	negative regulation of axon guidance (GO:1902668)	2.27468229
35	regulation of axon extension involved in axon guidance (GO:0048841)	2.27307892
36	central nervous system neuron axonogenesis (GO:0021955)	2.25423882
37	nucleobase catabolic process (GO:0046113)	2.22350064
38	positive regulation of synapse assembly (GO:0051965)	2.16277192
39	mechanosensory behavior (GO:0007638)	2.15271681
40	intraciliary transport (GO:0042073)	2.13741837
41	piRNA metabolic process (GO:0034587)	2.13022395
42	central nervous system projection neuron axonogenesis (GO:0021952)	2.11912897
43	negative regulation of keratinocyte proliferation (GO:0010839)	2.09898266
44	dendritic spine morphogenesis (GO:0060997)	2.08888458
45	body morphogenesis (GO:0010171)	2.08294945
46	neural tube formation (GO:0001841)	2.08265503
47	limb bud formation (GO:0060174)	2.07602974
48	artery development (GO:0060840)	2.07252045
49	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.05633814
50	regulation of transforming growth factor beta2 production (GO:0032909)	2.04930318
51	response to leptin (GO:0044321)	2.04641459
52	cerebral cortex cell migration (GO:0021795)	2.04312309
53	protein localization to synapse (GO:0035418)	2.04240591
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.04226776
55	hippo signaling (GO:0035329)	2.03999981
56	brain morphogenesis (GO:0048854)	2.02599438
57	asymmetric protein localization (GO:0008105)	2.01208665
58	establishment of nucleus localization (GO:0040023)	2.00359344
59	DNA methylation involved in gamete generation (GO:0043046)	2.00337978
60	righting reflex (GO:0060013)	1.99603194
61	lymphangiogenesis (GO:0001946)	1.98338134
62	cerebral cortex development (GO:0021987)	1.98192132
63	regulation of DNA methylation (GO:0044030)	1.97758752
64	negative regulation of axon extension involved in axon guidance (GO:0048843)	1.96674297
65	histone H2A acetylation (GO:0043968)	1.96435955
66	cilium morphogenesis (GO:0060271)	1.96184415
67	axon extension involved in axon guidance (GO:0048846)	1.95194479
68	neuron projection extension involved in neuron projection guidance (GO:1902284)	1.95194479
69	retinal ganglion cell axon guidance (GO:0031290)	1.94642975
70	multicellular organism reproduction (GO:0032504)	1.94511131
71	regulation of respiratory system process (GO:0044065)	1.93841682
72	synapse assembly (GO:0007416)	1.93437382
73	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	1.91499335
74	bone trabecula formation (GO:0060346)	1.91437300
75	cellular response to cholesterol (GO:0071397)	1.90827030
76	hindbrain development (GO:0030902)	1.90808350
77	urinary tract smooth muscle contraction (GO:0014848)	1.89674230
78	startle response (GO:0001964)	1.89237009
79	somite rostral/caudal axis specification (GO:0032525)	1.89212345
80	spinal cord development (GO:0021510)	1.88881458
81	retina layer formation (GO:0010842)	1.88785507
82	axon extension (GO:0048675)	1.88643100
83	regulation of short-term neuronal synaptic plasticity (GO:0048172)	1.88016308
84	cytoplasmic mRNA processing body assembly (GO:0033962)	1.87659090
85	dendrite morphogenesis (GO:0048813)	1.87574205
86	positive regulation of gastrulation (GO:2000543)	1.86002056
87	positive regulation of cell cycle G2/M phase transition (GO:1902751)	1.84704186
88	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	1.84704186
89	regulation of meiosis I (GO:0060631)	1.82485338
90	coenzyme catabolic process (GO:0009109)	1.82467526
91	chondrocyte proliferation (GO:0035988)	1.81584826
92	positive regulation of meiosis (GO:0045836)	1.81541318
93	glutamine metabolic process (GO:0006541)	1.80921388
94	lens morphogenesis in camera-type eye (GO:0002089)	1.80865529
95	positive regulation of protein autophosphorylation (GO:0031954)	1.80774755
96	neuron projection extension (GO:1990138)	1.80720337
97	replication fork processing (GO:0031297)	1.80518792
98	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	1.80439914
99	cytoskeleton-dependent intracellular transport (GO:0030705)	1.79827077
100	COPII vesicle coating (GO:0048208)	1.79761728

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.30555583
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.90603628
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.15465507
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78502640
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.69946544
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.55383183
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.54583991
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.47450543
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29276455
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21177005
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11729500
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04610326
13	FUS_26573619_Chip-Seq_HEK293_Human	1.97232766
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91689230
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.88397965
16	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.86991963
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.84677260
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.82800140
19	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.79500443
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.78276783
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.78116515
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76148567
23	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.76122552
24	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.71225664
25	EWS_26573619_Chip-Seq_HEK293_Human	1.69159290
26	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.64839674
27	P300_19829295_ChIP-Seq_ESCs_Human	1.64501430
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64179473
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.63058112
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.62052701
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.60334895
32	STAT3_23295773_ChIP-Seq_U87_Human	1.58632849
33	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.51410819
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49115865
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46997160
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45716026
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45501351
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.42202198
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42202198
40	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.39022869
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.38761207
42	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38052094
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37533797
44	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.36414035
45	AR_25329375_ChIP-Seq_VCAP_Human	1.35281026
46	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32277854
47	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.25312490
48	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.24384659
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24175652
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22737061
51	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.21809787
52	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21278008
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20655045
54	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20149629
55	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.19584214
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19553936
57	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19019295
58	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.18965240
59	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.18529591
60	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.18518860
61	* TCF4_23295773_ChIP-Seq_U87_Human	1.18485162
62	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18369966
63	TP53_18474530_ChIP-ChIP_U2OS_Human	1.18036445
64	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.17405214
65	SOX9_26525672_Chip-Seq_HEART_Mouse	1.14254206
66	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.13661462
67	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12238514
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12212098
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12120209
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10654634
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10654634
72	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.10217652
73	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09841506
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09795739
75	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.09299043
76	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.09180830
77	BCAT_22108803_ChIP-Seq_LS180_Human	1.08776879
78	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07710745
79	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07529400
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07489752
81	AHR_22903824_ChIP-Seq_MCF-7_Human	1.06620514
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06601246
83	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.05342802
84	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.05108151
85	VDR_22108803_ChIP-Seq_LS180_Human	1.05096784
86	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04671603
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04333842
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03451962
89	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03404567
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02913139
91	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.00295701
92	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99073070
93	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99073070
94	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.98997907
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98220494
96	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97380674
97	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.97268240
98	KDM2B_26808549_Chip-Seq_REH_Human	0.97137392
99	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.95996700
100	JUN_21703547_ChIP-Seq_K562_Human	0.95961352

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.26934786
2	MP0001529_abnormal_vocalization	2.24595488
3	MP0004272_abnormal_basement_membrane	2.00878694
4	MP0000778_abnormal_nervous_system	1.91639028
5	MP0003890_abnormal_embryonic-extraembry	1.90672402
6	MP0002909_abnormal_adrenal_gland	1.90649444
7	MP0003718_maternal_effect	1.85438300
8	MP0001299_abnormal_eye_distance/	1.81954802
9	MP0000566_synostosis	1.81650853
10	MP0006276_abnormal_autonomic_nervous	1.81260956
11	MP0010368_abnormal_lymphatic_system	1.73528338
12	MP0003122_maternal_imprinting	1.69855588
13	MP0003121_genomic_imprinting	1.69341668
14	MP0001984_abnormal_olfaction	1.61727601
15	MP0004270_analgesia	1.59454512
16	MP0008438_abnormal_cutaneous_collagen	1.55264377
17	MP0004859_abnormal_synaptic_plasticity	1.53541094
18	MP0009780_abnormal_chondrocyte_physiolo	1.49341327
19	MP0004885_abnormal_endolymph	1.44765875
20	MP0003937_abnormal_limbs/digits/tail_de	1.38386464
21	MP0002735_abnormal_chemical_nociception	1.37401609
22	MP0005394_taste/olfaction_phenotype	1.34965821
23	MP0005499_abnormal_olfactory_system	1.34965821
24	MP0009384_cardiac_valve_regurgitation	1.31961571
25	MP0003941_abnormal_skin_development	1.31402541
26	MP0000537_abnormal_urethra_morphology	1.31220005
27	MP0002653_abnormal_ependyma_morphology	1.30866139
28	MP0006054_spinal_hemorrhage	1.27873093
29	MP0000534_abnormal_ureter_morphology	1.25887487
30	MP0003755_abnormal_palate_morphology	1.25589393
31	MP0003136_yellow_coat_color	1.25326165
32	MP0002234_abnormal_pharynx_morphology	1.24551772
33	MP0003787_abnormal_imprinting	1.21476637
34	MP0008789_abnormal_olfactory_epithelium	1.21426230
35	MP0002837_dystrophic_cardiac_calcinosis	1.17254170
36	MP0006292_abnormal_olfactory_placode	1.16931488
37	MP0002938_white_spotting	1.16560221
38	MP0004134_abnormal_chest_morphology	1.15200959
39	MP0000428_abnormal_craniofacial_morphol	1.13146549
40	MP0002160_abnormal_reproductive_system	1.12200672
41	MP0000516_abnormal_urinary_system	1.11967484
42	MP0005367_renal/urinary_system_phenotyp	1.11967484
43	MP0003880_abnormal_central_pattern	1.11711315
44	MP0000013_abnormal_adipose_tissue	1.10691536
45	MP0003119_abnormal_digestive_system	1.09818675
46	MP0005275_abnormal_skin_tensile	1.09311335
47	MP0003942_abnormal_urinary_system	1.08227601
48	MP0001293_anophthalmia	1.06008061
49	MP0005623_abnormal_meninges_morphology	1.05176379
50	MP0005187_abnormal_penis_morphology	1.05102988
51	MP0006072_abnormal_retinal_apoptosis	1.04331129
52	MP0002697_abnormal_eye_size	1.03722481
53	MP0010352_gastrointestinal_tract_polyps	1.03409653
54	MP0005423_abnormal_somatic_nervous	1.03171733
55	MP0009250_abnormal_appendicular_skeleto	1.03152953
56	MP0002084_abnormal_developmental_patter	1.02361007
57	MP0000762_abnormal_tongue_morphology	1.02047682
58	MP0000579_abnormal_nail_morphology	1.00947414
59	MP0002233_abnormal_nose_morphology	1.00726634
60	MP0003861_abnormal_nervous_system	1.00378056
61	MP0010678_abnormal_skin_adnexa	1.00317286
62	MP0002822_catalepsy	1.00014164
63	MP0003935_abnormal_craniofacial_develop	0.99275144
64	MP0000631_abnormal_neuroendocrine_gland	0.99017365
65	MP0010234_abnormal_vibrissa_follicle	0.98829072
66	MP0002295_abnormal_pulmonary_circulatio	0.97967153
67	MP0003283_abnormal_digestive_organ	0.96316950
68	MP0003385_abnormal_body_wall	0.94828675
69	MP0003635_abnormal_synaptic_transmissio	0.93946256
70	MP0003123_paternal_imprinting	0.93596584
71	MP0002163_abnormal_gland_morphology	0.93526315
72	MP0000427_abnormal_hair_cycle	0.93421793
73	MP0010030_abnormal_orbit_morphology	0.92989158
74	MP0000049_abnormal_middle_ear	0.92447842
75	MP0001177_atelectasis	0.92073722
76	MP0002184_abnormal_innervation	0.92046188
77	MP0000383_abnormal_hair_follicle	0.92013573
78	MP0004145_abnormal_muscle_electrophysio	0.91656759
79	MP0002734_abnormal_mechanical_nocicepti	0.90491565
80	MP0002557_abnormal_social/conspecific_i	0.90225106
81	MP0001286_abnormal_eye_development	0.88613547
82	MP0000647_abnormal_sebaceous_gland	0.87260088
83	MP0008057_abnormal_DNA_replication	0.86033920
84	MP0002572_abnormal_emotion/affect_behav	0.85849771
85	MP0005503_abnormal_tendon_morphology	0.82969022
86	MP0002116_abnormal_craniofacial_bone	0.82682995
87	MP0002272_abnormal_nervous_system	0.82014070
88	MP0004924_abnormal_behavior	0.80665783
89	MP0005386_behavior/neurological_phenoty	0.80665783
90	MP0002085_abnormal_embryonic_tissue	0.79904650
91	MP0002152_abnormal_brain_morphology	0.79877736
92	MP0002081_perinatal_lethality	0.77998002
93	MP0001879_abnormal_lymphatic_vessel	0.77900501
94	MP0005508_abnormal_skeleton_morphology	0.76454857
95	MP0001486_abnormal_startle_reflex	0.76002588
96	MP0009046_muscle_twitch	0.75665587
97	MP0003567_abnormal_fetal_cardiomyocyte	0.75529722
98	MP0000955_abnormal_spinal_cord	0.74444033
99	MP0004811_abnormal_neuron_physiology	0.74328225
100	MP0002882_abnormal_neuron_morphology	0.74270843

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatoblastoma (HP:0002884)	5.47567304
2	Hypoglycemic coma (HP:0001325)	4.82859613
3	Hypoglycemic seizures (HP:0002173)	4.24469000
4	Hyperinsulinemic hypoglycemia (HP:0000825)	3.97424601
5	Proximal tubulopathy (HP:0000114)	3.36133360
6	Abnormality of dentin (HP:0010299)	2.77092404
7	Gout (HP:0001997)	2.75777426
8	Papillary thyroid carcinoma (HP:0002895)	2.55213062
9	Symptomatic seizures (HP:0011145)	2.54265326
10	Abnormality of the metopic suture (HP:0005556)	2.48522194
11	EEG with generalized epileptiform discharges (HP:0011198)	2.33003936
12	Abnormality of the pancreatic islet cells (HP:0006476)	2.31878208
13	Abnormality of endocrine pancreas physiology (HP:0012093)	2.31878208
14	Hypsarrhythmia (HP:0002521)	2.30254298
15	Median cleft lip (HP:0000161)	2.27584456
16	Gait imbalance (HP:0002141)	2.24206382
17	Epileptiform EEG discharges (HP:0011182)	2.23086413
18	Prominent metopic ridge (HP:0005487)	2.22719827
19	Nephronophthisis (HP:0000090)	2.20818050
20	Abnormality of the labia minora (HP:0012880)	2.17728282
21	Medial flaring of the eyebrow (HP:0010747)	2.16908574
22	Congenital primary aphakia (HP:0007707)	2.08949050
23	Pancreatic cysts (HP:0001737)	2.07530019
24	Coronal craniosynostosis (HP:0004440)	2.07491511
25	Follicular hyperkeratosis (HP:0007502)	2.05782145
26	Thyroid carcinoma (HP:0002890)	2.05417044
27	Genital tract atresia (HP:0001827)	2.01867057
28	Chronic hepatic failure (HP:0100626)	1.99568192
29	Neoplasm of the oral cavity (HP:0100649)	1.97977765
30	Hydroureter (HP:0000072)	1.97939378
31	Astrocytoma (HP:0009592)	1.97764526
32	Abnormality of the astrocytes (HP:0100707)	1.97764526
33	Postaxial hand polydactyly (HP:0001162)	1.97092019
34	Ketosis (HP:0001946)	1.95523586
35	Intestinal atresia (HP:0011100)	1.94956211
36	Vaginal atresia (HP:0000148)	1.94573038
37	Late onset (HP:0003584)	1.93239822
38	Abnormality of the renal cortex (HP:0011035)	1.90242863
39	Ketoacidosis (HP:0001993)	1.88250641
40	Hyperglycemia (HP:0003074)	1.86481985
41	Bifid tongue (HP:0010297)	1.84225547
42	Gonadotropin excess (HP:0000837)	1.80355907
43	Tubular atrophy (HP:0000092)	1.80272485
44	Nephrogenic diabetes insipidus (HP:0009806)	1.80206813
45	Pancreatic fibrosis (HP:0100732)	1.79816827
46	Abnormality of the renal medulla (HP:0100957)	1.78691782
47	Abnormality of midbrain morphology (HP:0002418)	1.78013596
48	Molar tooth sign on MRI (HP:0002419)	1.78013596
49	Facial hemangioma (HP:0000329)	1.77885313
50	Supernumerary spleens (HP:0009799)	1.76177758
51	Drooling (HP:0002307)	1.71494985
52	Atonic seizures (HP:0010819)	1.70851175
53	Glioma (HP:0009733)	1.70162981
54	Intellectual disability, moderate (HP:0002342)	1.68198422
55	Ependymoma (HP:0002888)	1.64696549
56	Poor coordination (HP:0002370)	1.63972639
57	Cutaneous finger syndactyly (HP:0010554)	1.63959104
58	Wide anterior fontanel (HP:0000260)	1.63242085
59	Anterior segment dysgenesis (HP:0007700)	1.62301030
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.61112412
61	Enlarged kidneys (HP:0000105)	1.59403651
62	Abnormality of the phalanges of the hallux (HP:0010057)	1.58787395
63	Heterotopia (HP:0002282)	1.58440263
64	Premature rupture of membranes (HP:0001788)	1.58023455
65	Shawl scrotum (HP:0000049)	1.56393598
66	Hypoplastic scapulae (HP:0000882)	1.56014663
67	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.56014663
68	Decreased testicular size (HP:0008734)	1.55578534
69	Hemiparesis (HP:0001269)	1.53562162
70	Renal hypoplasia (HP:0000089)	1.53549591
71	Short tibia (HP:0005736)	1.52507583
72	Pachygyria (HP:0001302)	1.50670140
73	Abnormality of the aortic arch (HP:0012303)	1.49173831
74	Facial cleft (HP:0002006)	1.48994628
75	Short foot (HP:0001773)	1.48350337
76	Atrophic scars (HP:0001075)	1.48162780
77	Omphalocele (HP:0001539)	1.47917839
78	Hypoplastic labia majora (HP:0000059)	1.46288982
79	Unilateral renal agenesis (HP:0000122)	1.45913612
80	Atrioventricular canal defect (HP:0006695)	1.45861218
81	Muscular hypotonia of the trunk (HP:0008936)	1.44600500
82	Bicornuate uterus (HP:0000813)	1.44161596
83	Action tremor (HP:0002345)	1.43453827
84	Oligodactyly (hands) (HP:0001180)	1.43373215
85	Complete atrioventricular canal defect (HP:0001674)	1.43099963
86	Septo-optic dysplasia (HP:0100842)	1.42777511
87	Cortical dysplasia (HP:0002539)	1.41521536
88	Micropenis (HP:0000054)	1.41384092
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.40389173
90	Stage 5 chronic kidney disease (HP:0003774)	1.40091774
91	Shallow orbits (HP:0000586)	1.39334084
92	Hypomagnesemia (HP:0002917)	1.38539787
93	True hermaphroditism (HP:0010459)	1.38361279
94	Neonatal short-limb short stature (HP:0008921)	1.38031638
95	Excessive salivation (HP:0003781)	1.37965616
96	Bowel diverticulosis (HP:0005222)	1.37748698
97	Focal segmental glomerulosclerosis (HP:0000097)	1.37551068
98	Medulloblastoma (HP:0002885)	1.37378152
99	Dental crowding (HP:0000678)	1.37257754
100	Cutaneous syndactyly (HP:0012725)	1.36389310

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	3.92201890
2	FRK	3.89509217
3	PNCK	3.36013152
4	PDK2	2.74225780
5	MARK1	2.69890953
6	MAP3K4	2.05105096
7	TRIM28	2.04996892
8	EPHB2	1.94787922
9	MAP3K9	1.83815972
10	BCR	1.81954906
11	NTRK2	1.76290529
12	CSNK1G1	1.71475568
13	MAP2K7	1.68576436
14	FGFR2	1.64759646
15	PINK1	1.60908067
16	WNK3	1.58749739
17	STK3	1.55358240
18	ARAF	1.54336353
19	EIF2AK3	1.48034497
20	TNIK	1.41062221
21	MAPK13	1.39797813
22	CAMK1G	1.38426944
23	NTRK1	1.34470902
24	NTRK3	1.24074417
25	CSNK1G2	1.24044064
26	PLK2	1.21109771
27	DDR2	1.21070842
28	CDC7	1.20520133
29	CSNK1G3	1.18864155
30	EPHA3	1.17180288
31	NEK6	1.13539918
32	MET	1.13156559
33	CSNK1A1L	1.06767783
34	STK38	1.05190512
35	PTK2	1.03604854
36	SRPK1	1.00990017
37	ERBB4	0.99847376
38	DYRK2	0.98832296
39	KSR1	0.98653895
40	BRD4	0.97303391
41	MAPK7	0.97225094
42	NEK9	0.94790833
43	BMPR1B	0.94530164
44	PAK2	0.91370114
45	PLK3	0.87990969
46	TIE1	0.86027000
47	PRKCE	0.85788932
48	PDGFRA	0.84672476
49	ERBB3	0.82766262
50	CAMK2D	0.79611975
51	PRKD3	0.78078972
52	TTK	0.77093373
53	AKT3	0.74891090
54	MAPK15	0.74395856
55	PAK6	0.74276440
56	TSSK6	0.73115707
57	DYRK1A	0.71244050
58	SGK2	0.71164407
59	PRKD2	0.69400550
60	PHKG2	0.68223929
61	PHKG1	0.68223929
62	PLK4	0.66252343
63	MAP4K2	0.65360229
64	NLK	0.64657353
65	PAK3	0.64132067
66	ROCK1	0.63235886
67	MOS	0.62685987
68	SCYL2	0.62538969
69	TGFBR1	0.61007255
70	CDK9	0.60718625
71	ATM	0.60513129
72	FER	0.59433069
73	SGK494	0.59078700
74	SGK223	0.59078700
75	RAF1	0.58793998
76	PRKCG	0.57203629
77	CSNK1A1	0.57144178
78	GRK1	0.56835233
79	CAMK2B	0.56405405
80	AURKA	0.55700394
81	LATS1	0.53779114
82	YES1	0.51959719
83	CAMK2G	0.51393366
84	CDK3	0.51245338
85	PRKCZ	0.50458083
86	MTOR	0.50382262
87	LATS2	0.50176599
88	BCKDK	0.49818109
89	CAMK2A	0.49249993
90	GSK3A	0.48359391
91	ROCK2	0.48254141
92	PRKACB	0.48204232
93	PRKCI	0.47417638
94	PLK1	0.47293127
95	CDK8	0.47068636
96	DYRK3	0.46553553
97	MKNK2	0.45978562
98	CSNK1E	0.45824561
99	CDK5	0.45626931
100	SGK3	0.44442934

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.59423652
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42750255
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.28336316
4	Butanoate metabolism_Homo sapiens_hsa00650	2.22790754
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.12513292
6	Insulin secretion_Homo sapiens_hsa04911	1.93522339
7	Fatty acid elongation_Homo sapiens_hsa00062	1.90786186
8	Propanoate metabolism_Homo sapiens_hsa00640	1.73086465
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.68812113
10	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.60464433
11	Basal transcription factors_Homo sapiens_hsa03022	1.50833481
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42274663
13	Hippo signaling pathway_Homo sapiens_hsa04390	1.40508247
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38170980
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34257310
16	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.33126770
17	ECM-receptor interaction_Homo sapiens_hsa04512	1.30311810
18	Fatty acid metabolism_Homo sapiens_hsa01212	1.20205992
19	Regulation of autophagy_Homo sapiens_hsa04140	1.19723945
20	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.17849221
21	Nicotine addiction_Homo sapiens_hsa05033	1.17350708
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.16923337
23	Axon guidance_Homo sapiens_hsa04360	1.16797761
24	Protein export_Homo sapiens_hsa03060	1.13221825
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.11006825
26	GABAergic synapse_Homo sapiens_hsa04727	1.10663757
27	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.07205421
28	Lysine degradation_Homo sapiens_hsa00310	1.06961179
29	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.05727830
30	Gap junction_Homo sapiens_hsa04540	1.05487489
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00428398
32	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.98448876
33	Glutamatergic synapse_Homo sapiens_hsa04724	0.95748036
34	Basal cell carcinoma_Homo sapiens_hsa05217	0.94590396
35	Oocyte meiosis_Homo sapiens_hsa04114	0.93490316
36	Cocaine addiction_Homo sapiens_hsa05030	0.90954084
37	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.89466137
38	Adherens junction_Homo sapiens_hsa04520	0.86481432
39	Tight junction_Homo sapiens_hsa04530	0.85363905
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.85352300
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85037164
42	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.84830305
43	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.83024926
44	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.82908733
45	Long-term depression_Homo sapiens_hsa04730	0.82590478
46	Taste transduction_Homo sapiens_hsa04742	0.82052700
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.81931189
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81599354
49	Protein digestion and absorption_Homo sapiens_hsa04974	0.79643228
50	RNA transport_Homo sapiens_hsa03013	0.79482734
51	Circadian entrainment_Homo sapiens_hsa04713	0.77479968
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77329850
53	Melanogenesis_Homo sapiens_hsa04916	0.77058275
54	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.76848501
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.76591954
56	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.75459246
57	Melanoma_Homo sapiens_hsa05218	0.75025120
58	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.74767929
59	Wnt signaling pathway_Homo sapiens_hsa04310	0.73921012
60	Phototransduction_Homo sapiens_hsa04744	0.73890801
61	ABC transporters_Homo sapiens_hsa02010	0.73677050
62	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.72907937
63	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70454982
64	Focal adhesion_Homo sapiens_hsa04510	0.70335559
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.69290476
66	Cell cycle_Homo sapiens_hsa04110	0.67122849
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.67045609
68	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.67029343
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.66935079
70	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.66692460
71	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.66602118
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.66024633
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65526707
74	Circadian rhythm_Homo sapiens_hsa04710	0.65163236
75	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.62965740
76	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.61354379
77	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.61201169
78	Glucagon signaling pathway_Homo sapiens_hsa04922	0.60087742
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.59315363
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59092314
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.58238195
82	MicroRNAs in cancer_Homo sapiens_hsa05206	0.57356729
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56497172
84	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.55172684
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.54820655
86	Amphetamine addiction_Homo sapiens_hsa05031	0.53587839
87	Cholinergic synapse_Homo sapiens_hsa04725	0.52357175
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.51537178
89	Homologous recombination_Homo sapiens_hsa03440	0.50956112
90	RNA degradation_Homo sapiens_hsa03018	0.50338573
91	Morphine addiction_Homo sapiens_hsa05032	0.49278312
92	Rap1 signaling pathway_Homo sapiens_hsa04015	0.48809092
93	Serotonergic synapse_Homo sapiens_hsa04726	0.47837870
94	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.47492051
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.47265448
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47136572
97	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.46460588
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.45336506
99	Fatty acid degradation_Homo sapiens_hsa00071	0.45265664
100	Mismatch repair_Homo sapiens_hsa03430	0.44961645

ZNF229

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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