ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-fucose catabolic process (GO:0042355)	4.85458506
2	fucose catabolic process (GO:0019317)	4.85458506
3	L-fucose metabolic process (GO:0042354)	4.85458506
4	piRNA metabolic process (GO:0034587)	4.22473015
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.03431972
6	epithelial cilium movement (GO:0003351)	3.92797069
7	axoneme assembly (GO:0035082)	3.84537416
8	regulation of hippo signaling (GO:0035330)	3.69626588
9	cornea development in camera-type eye (GO:0061303)	3.67637321
10	cilium movement (GO:0003341)	3.59445209
11	regulation of glucokinase activity (GO:0033131)	3.51164101
12	regulation of hexokinase activity (GO:1903299)	3.51164101
13	neural tube formation (GO:0001841)	3.50306495
14	behavioral response to nicotine (GO:0035095)	3.42770002
15	cilium morphogenesis (GO:0060271)	3.40617531
16	positive regulation of mitochondrial fission (GO:0090141)	3.39866064
17	cell wall macromolecule catabolic process (GO:0016998)	3.36634262
18	cilium or flagellum-dependent cell motility (GO:0001539)	3.33044717
19	intraciliary transport (GO:0042073)	3.29956880
20	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.26353953
21	somite development (GO:0061053)	3.22874219
22	DNA methylation involved in gamete generation (GO:0043046)	3.19703442
23	cullin deneddylation (GO:0010388)	3.18155138
24	nonmotile primary cilium assembly (GO:0035058)	3.15850700
25	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.09965618
26	peptidyl-histidine modification (GO:0018202)	3.09381160
27	single strand break repair (GO:0000012)	3.08218748
28	synapsis (GO:0007129)	2.96903841
29	pyrimidine nucleobase catabolic process (GO:0006208)	2.96255964
30	male meiosis (GO:0007140)	2.94976624
31	regulation of cilium movement (GO:0003352)	2.94188644
32	indole-containing compound catabolic process (GO:0042436)	2.92399814
33	indolalkylamine catabolic process (GO:0046218)	2.92399814
34	tryptophan catabolic process (GO:0006569)	2.92399814
35	preassembly of GPI anchor in ER membrane (GO:0016254)	2.92287411
36	water-soluble vitamin biosynthetic process (GO:0042364)	2.91272119
37	fucosylation (GO:0036065)	2.91197368
38	resolution of meiotic recombination intermediates (GO:0000712)	2.89101609
39	DNA double-strand break processing (GO:0000729)	2.86668232
40	cilium organization (GO:0044782)	2.85710179
41	protein localization to cilium (GO:0061512)	2.85177010
42	regulation of protein glycosylation (GO:0060049)	2.84088841
43	protein localization to Golgi apparatus (GO:0034067)	2.82731562
44	cell wall macromolecule metabolic process (GO:0044036)	2.82086452
45	platelet dense granule organization (GO:0060155)	2.81631836
46	coenzyme catabolic process (GO:0009109)	2.81447485
47	cilium assembly (GO:0042384)	2.81154999
48	establishment of protein localization to Golgi (GO:0072600)	2.80851611
49	melanosome localization (GO:0032400)	2.76712845
50	C4-dicarboxylate transport (GO:0015740)	2.75739173
51	acrosome reaction (GO:0007340)	2.75366779
52	protein targeting to Golgi (GO:0000042)	2.74930808
53	dopamine transport (GO:0015872)	2.74167829
54	presynaptic membrane assembly (GO:0097105)	2.73820049
55	axonemal dynein complex assembly (GO:0070286)	2.70888973
56	protein K11-linked deubiquitination (GO:0035871)	2.70871188
57	protein deneddylation (GO:0000338)	2.68158309
58	transmission of nerve impulse (GO:0019226)	2.67483032
59	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.65416641
60	regulation of mitotic spindle checkpoint (GO:1903504)	2.65416641
61	iron-sulfur cluster assembly (GO:0016226)	2.63638764
62	metallo-sulfur cluster assembly (GO:0031163)	2.63638764
63	nucleobase catabolic process (GO:0046113)	2.63228443
64	indolalkylamine metabolic process (GO:0006586)	2.62119391
65	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.61172198
66	pigment granule localization (GO:0051875)	2.60380062
67	negative regulation of mast cell activation (GO:0033004)	2.59229739
68	protein polyglutamylation (GO:0018095)	2.59106727
69	detection of light stimulus involved in visual perception (GO:0050908)	2.57765087
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.57765087
71	protein complex biogenesis (GO:0070271)	2.57508533
72	fucose metabolic process (GO:0006004)	2.57368318
73	response to pheromone (GO:0019236)	2.57271882
74	retinal cone cell development (GO:0046549)	2.56568566
75	male meiosis I (GO:0007141)	2.56365475
76	melanosome transport (GO:0032402)	2.55082482
77	seminiferous tubule development (GO:0072520)	2.54966831
78	isoprenoid biosynthetic process (GO:0008299)	2.54850120
79	limb bud formation (GO:0060174)	2.52764943
80	protein-cofactor linkage (GO:0018065)	2.51167444
81	neuron cell-cell adhesion (GO:0007158)	2.50798675
82	DNA damage response, detection of DNA damage (GO:0042769)	2.50711929
83	establishment of melanosome localization (GO:0032401)	2.48541605
84	centriole replication (GO:0007099)	2.47033381
85	snRNA transcription (GO:0009301)	2.43184820
86	tryptophan metabolic process (GO:0006568)	2.42093898
87	signal peptide processing (GO:0006465)	2.41920457
88	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.41916086
89	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.41916086
90	protein prenylation (GO:0018342)	2.38801464
91	prenylation (GO:0097354)	2.38801464
92	postsynaptic membrane organization (GO:0001941)	2.38629546
93	pigment granule transport (GO:0051904)	2.37505700
94	S-adenosylmethionine metabolic process (GO:0046500)	2.36862038
95	response to redox state (GO:0051775)	2.36703889
96	intra-Golgi vesicle-mediated transport (GO:0006891)	2.36680032
97	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.35009139
98	brain morphogenesis (GO:0048854)	2.34812982
99	regulation of telomere maintenance (GO:0032204)	2.33630315
100	microtubule bundle formation (GO:0001578)	2.32764089

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.67140872
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.10156971
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.03686680
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.95762019
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75463897
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.63139220
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.47084456
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.46463239
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42400595
10	FUS_26573619_Chip-Seq_HEK293_Human	2.40319981
11	VDR_22108803_ChIP-Seq_LS180_Human	2.39167363
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.33616972
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32985763
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28556601
15	P300_19829295_ChIP-Seq_ESCs_Human	2.15664455
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.09458325
17	EWS_26573619_Chip-Seq_HEK293_Human	2.06658187
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.05893514
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05789241
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04972810
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04539009
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.04231927
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.96631139
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83266167
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.76158560
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68616277
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62126332
28	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59576551
29	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58304277
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57000871
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56273668
32	EZH2_22144423_ChIP-Seq_EOC_Human	1.55745369
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52910824
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52780544
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51364951
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51073921
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49093703
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49003950
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47061060
40	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.46095670
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45996333
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.44623194
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.42641272
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42575367
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42310510
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.42310510
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42245624
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41759539
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.40005185
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39126625
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38466551
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38403192
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37372782
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36149512
55	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35187085
56	TCF4_23295773_ChIP-Seq_U87_Human	1.35093412
57	STAT3_23295773_ChIP-Seq_U87_Human	1.35090323
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32801986
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32801986
60	AR_25329375_ChIP-Seq_VCAP_Human	1.32483095
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31951959
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31555285
63	VDR_23849224_ChIP-Seq_CD4+_Human	1.30932883
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29712057
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.29107696
66	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.28252364
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27297923
68	BCAT_22108803_ChIP-Seq_LS180_Human	1.27104414
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24921302
70	P53_22387025_ChIP-Seq_ESCs_Mouse	1.24387396
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.23350722
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21903795
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20257772
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20257772
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18878993
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.17785023
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17629951
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17408194
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17408194
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17391334
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15867502
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14270809
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12732204
84	JUN_21703547_ChIP-Seq_K562_Human	1.10637000
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10546803
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10099718
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.09924652
88	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09873224
89	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.09395129
90	AR_21572438_ChIP-Seq_LNCaP_Human	1.09278968
91	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08790544
92	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07177479
93	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06898562
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06643885
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06582781
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05223663
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.04614790
98	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.03495451
99	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.00528047
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00396507

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001984_abnormal_olfaction	3.48970430
2	MP0008877_abnormal_DNA_methylation	3.10443785
3	MP0002102_abnormal_ear_morphology	3.01710130
4	MP0004147_increased_porphyrin_level	2.97309145
5	MP0002653_abnormal_ependyma_morphology	2.69491570
6	MP0003787_abnormal_imprinting	2.64337937
7	MP0003880_abnormal_central_pattern	2.49490810
8	MP0003122_maternal_imprinting	2.43677380
9	MP0001529_abnormal_vocalization	2.37683839
10	MP0002837_dystrophic_cardiac_calcinosis	2.35493465
11	MP0009046_muscle_twitch	2.12267264
12	MP0002876_abnormal_thyroid_physiology	2.00699020
13	MP0001986_abnormal_taste_sensitivity	1.93318443
14	MP0005551_abnormal_eye_electrophysiolog	1.90384434
15	MP0003121_genomic_imprinting	1.80803318
16	MP0006072_abnormal_retinal_apoptosis	1.79997728
17	MP0003195_calcinosis	1.79057990
18	MP0005646_abnormal_pituitary_gland	1.76033749
19	MP0002638_abnormal_pupillary_reflex	1.75984632
20	MP0003950_abnormal_plasma_membrane	1.72686305
21	MP0008058_abnormal_DNA_repair	1.71194646
22	MP0004142_abnormal_muscle_tone	1.70863248
23	MP0005253_abnormal_eye_physiology	1.60174659
24	MP0009745_abnormal_behavioral_response	1.56076714
25	MP0002751_abnormal_autonomic_nervous	1.51467690
26	MP0002272_abnormal_nervous_system	1.50369297
27	MP0003718_maternal_effect	1.50343040
28	MP0008789_abnormal_olfactory_epithelium	1.46452749
29	MP0005084_abnormal_gallbladder_morpholo	1.46364228
30	MP0006276_abnormal_autonomic_nervous	1.43243297
31	MP0004043_abnormal_pH_regulation	1.42932148
32	MP0001486_abnormal_startle_reflex	1.41241131
33	MP0008875_abnormal_xenobiotic_pharmacok	1.40016307
34	MP0002572_abnormal_emotion/affect_behav	1.39084895
35	MP0001501_abnormal_sleep_pattern	1.37839479
36	MP0005645_abnormal_hypothalamus_physiol	1.37782835
37	MP0002163_abnormal_gland_morphology	1.35996445
38	MP0005075_abnormal_melanosome_morpholog	1.34790907
39	MP0003890_abnormal_embryonic-extraembry	1.34204471
40	MP0004885_abnormal_endolymph	1.33980926
41	MP0000569_abnormal_digit_pigmentation	1.33659275
42	MP0001968_abnormal_touch/_nociception	1.32482686
43	MP0002822_catalepsy	1.32326455
44	MP0000631_abnormal_neuroendocrine_gland	1.30718671
45	MP0004270_analgesia	1.29956070
46	MP0001905_abnormal_dopamine_level	1.29332359
47	MP0002734_abnormal_mechanical_nocicepti	1.28978628
48	MP0003635_abnormal_synaptic_transmissio	1.26656195
49	MP0005499_abnormal_olfactory_system	1.22466014
50	MP0005394_taste/olfaction_phenotype	1.22466014
51	MP0005379_endocrine/exocrine_gland_phen	1.20651163
52	MP0002557_abnormal_social/conspecific_i	1.19499070
53	MP0008995_early_reproductive_senescence	1.18608600
54	MP0004133_heterotaxia	1.18049675
55	MP0000778_abnormal_nervous_system	1.17373180
56	MP0003656_abnormal_erythrocyte_physiolo	1.16167504
57	MP0001919_abnormal_reproductive_system	1.13630616
58	MP0002063_abnormal_learning/memory/cond	1.11293263
59	MP0005389_reproductive_system_phenotype	1.09744553
60	MP0002909_abnormal_adrenal_gland	1.06864496
61	MP0004924_abnormal_behavior	1.04974269
62	MP0005386_behavior/neurological_phenoty	1.04974269
63	MP0004215_abnormal_myocardial_fiber	1.02747422
64	MP0002736_abnormal_nociception_after	1.01865375
65	MP0002938_white_spotting	1.01795955
66	MP0006035_abnormal_mitochondrial_morpho	1.00067927
67	MP0006054_spinal_hemorrhage	0.99837946
68	MP0005332_abnormal_amino_acid	0.99379065
69	MP0002064_seizures	0.98928528
70	MP0002928_abnormal_bile_duct	0.98241739
71	MP0003937_abnormal_limbs/digits/tail_de	0.98023867
72	MP0002067_abnormal_sensory_capabilities	0.97705787
73	MP0005410_abnormal_fertilization	0.95102163
74	MP0001502_abnormal_circadian_rhythm	0.94203202
75	MP0003698_abnormal_male_reproductive	0.93973959
76	MP0002184_abnormal_innervation	0.93452520
77	MP0001970_abnormal_pain_threshold	0.93440286
78	MP0003119_abnormal_digestive_system	0.93265684
79	MP0005171_absent_coat_pigmentation	0.92193228
80	MP0000427_abnormal_hair_cycle	0.91737692
81	MP0004859_abnormal_synaptic_plasticity	0.91355160
82	MP0000049_abnormal_middle_ear	0.90810443
83	MP0001929_abnormal_gametogenesis	0.89594343
84	MP0002177_abnormal_outer_ear	0.88339313
85	MP0000647_abnormal_sebaceous_gland	0.88126586
86	MP0002160_abnormal_reproductive_system	0.88017803
87	MP0004811_abnormal_neuron_physiology	0.87414496
88	MP0002735_abnormal_chemical_nociception	0.87202636
89	MP0002733_abnormal_thermal_nociception	0.86586753
90	MP0003186_abnormal_redox_activity	0.85604493
91	MP0009780_abnormal_chondrocyte_physiolo	0.84550916
92	MP0002095_abnormal_skin_pigmentation	0.84285258
93	MP0000372_irregular_coat_pigmentation	0.83443771
94	MP0002229_neurodegeneration	0.83411164
95	MP0002882_abnormal_neuron_morphology	0.82042668
96	MP0003136_yellow_coat_color	0.81981918
97	MP0001324_abnormal_eye_pigmentation	0.81271784
98	MP0003633_abnormal_nervous_system	0.80304825
99	MP0002752_abnormal_somatic_nervous	0.80064149
100	MP0001944_abnormal_pancreas_morphology	0.79815535

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	4.29090821
2	Gait imbalance (HP:0002141)	3.86260159
3	Congenital primary aphakia (HP:0007707)	3.78410919
4	Pancreatic cysts (HP:0001737)	3.76191582
5	Nephrogenic diabetes insipidus (HP:0009806)	3.73934669
6	Molar tooth sign on MRI (HP:0002419)	3.65101542
7	Abnormality of midbrain morphology (HP:0002418)	3.65101542
8	Type II lissencephaly (HP:0007260)	3.61685343
9	True hermaphroditism (HP:0010459)	3.60537483
10	Pancreatic fibrosis (HP:0100732)	3.57104118
11	Nephronophthisis (HP:0000090)	3.21259243
12	Genital tract atresia (HP:0001827)	3.01923030
13	Vaginal atresia (HP:0000148)	2.93624622
14	Lissencephaly (HP:0001339)	2.83738323
15	Congenital stationary night blindness (HP:0007642)	2.79184823
16	Methylmalonic acidemia (HP:0002912)	2.67220756
17	Abnormality of the renal cortex (HP:0011035)	2.63241669
18	Renal cortical cysts (HP:0000803)	2.60630537
19	Hyperventilation (HP:0002883)	2.60575493
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.59242258
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.59242258
22	Stomach cancer (HP:0012126)	2.59129625
23	Chronic hepatic failure (HP:0100626)	2.57685799
24	Poor coordination (HP:0002370)	2.56482941
25	Febrile seizures (HP:0002373)	2.56347677
26	Hypothermia (HP:0002045)	2.56148708
27	Abnormality of the renal medulla (HP:0100957)	2.54966591
28	Retinal dysplasia (HP:0007973)	2.52255463
29	Delayed gross motor development (HP:0002194)	2.48868237
30	Oligodactyly (hands) (HP:0001180)	2.45201981
31	Methylmalonic aciduria (HP:0012120)	2.41165094
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39293037
33	Absent/shortened dynein arms (HP:0200106)	2.39293037
34	Cystic liver disease (HP:0006706)	2.37759173
35	Abnormal ciliary motility (HP:0012262)	2.36646326
36	Intestinal atresia (HP:0011100)	2.34920585
37	Postaxial hand polydactyly (HP:0001162)	2.32689337
38	Progressive inability to walk (HP:0002505)	2.28632157
39	Colon cancer (HP:0003003)	2.26863253
40	Amyotrophic lateral sclerosis (HP:0007354)	2.26178923
41	Progressive macrocephaly (HP:0004481)	2.24632669
42	Absent speech (HP:0001344)	2.24436994
43	Drooling (HP:0002307)	2.23901709
44	Postaxial foot polydactyly (HP:0001830)	2.23799000
45	Acute necrotizing encephalopathy (HP:0006965)	2.23259790
46	Gaze-evoked nystagmus (HP:0000640)	2.23067770
47	Abnormal respiratory motile cilium physiology (HP:0012261)	2.22332184
48	Ketoacidosis (HP:0001993)	2.22318532
49	Broad-based gait (HP:0002136)	2.21575932
50	Hemiparesis (HP:0001269)	2.21094338
51	Specific learning disability (HP:0001328)	2.18509785
52	Inability to walk (HP:0002540)	2.13305552
53	Abnormal mitochondria in muscle tissue (HP:0008316)	2.12666474
54	Focal motor seizures (HP:0011153)	2.11919099
55	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.09266917
56	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.09266917
57	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.06444129
58	Rhinitis (HP:0012384)	2.04412137
59	Aplasia/Hypoplasia of the lens (HP:0008063)	2.01339094
60	Abnormality of the labia minora (HP:0012880)	2.00927814
61	Sclerocornea (HP:0000647)	2.00716874
62	Anencephaly (HP:0002323)	2.00403543
63	Excessive salivation (HP:0003781)	1.97783300
64	Abnormal rod and cone electroretinograms (HP:0008323)	1.96680698
65	Severe muscular hypotonia (HP:0006829)	1.92573849
66	Pachygyria (HP:0001302)	1.92132602
67	Progressive cerebellar ataxia (HP:0002073)	1.90682377
68	Oculomotor apraxia (HP:0000657)	1.89769322
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89364619
70	Polyphagia (HP:0002591)	1.89003916
71	Decreased testicular size (HP:0008734)	1.88325648
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86442854
73	Broad foot (HP:0001769)	1.86011643
74	Limb dystonia (HP:0002451)	1.85244060
75	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.85084447
76	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.85084447
77	Dandy-Walker malformation (HP:0001305)	1.82970630
78	Astigmatism (HP:0000483)	1.82886775
79	Abnormality of the metopic suture (HP:0005556)	1.81024584
80	Preaxial hand polydactyly (HP:0001177)	1.79155849
81	3-Methylglutaconic aciduria (HP:0003535)	1.78707235
82	Labial hypoplasia (HP:0000066)	1.78175014
83	Abnormality of the musculature of the pelvis (HP:0001469)	1.76370394
84	Abnormality of the hip-girdle musculature (HP:0001445)	1.76370394
85	Shoulder girdle muscle weakness (HP:0003547)	1.76157217
86	Hypoglycemic coma (HP:0001325)	1.75613137
87	Calf muscle hypertrophy (HP:0008981)	1.75131691
88	Occipital encephalocele (HP:0002085)	1.74903519
89	Focal seizures (HP:0007359)	1.74665918
90	Acute encephalopathy (HP:0006846)	1.74496394
91	Short foot (HP:0001773)	1.73928731
92	Furrowed tongue (HP:0000221)	1.73750233
93	Cerebellar dysplasia (HP:0007033)	1.73351909
94	Retinitis pigmentosa (HP:0000510)	1.72858179
95	Abnormality of the corticospinal tract (HP:0002492)	1.72793532
96	Attenuation of retinal blood vessels (HP:0007843)	1.71825299
97	Hepatic necrosis (HP:0002605)	1.70612479
98	Hyperglycinemia (HP:0002154)	1.70432776
99	Narrow forehead (HP:0000341)	1.68442127
100	Increased corneal curvature (HP:0100692)	1.67441636

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.54411996
2	PINK1	3.51423235
3	WNK3	3.18055454
4	STK38L	2.95218629
5	CASK	2.73169678
6	BCR	2.66838436
7	TRIM28	2.58797895
8	STK24	2.52792598
9	MAP4K2	2.15701751
10	TAOK3	2.11377768
11	MAP3K4	2.05191051
12	SIK2	1.95771369
13	ERBB3	1.95366667
14	BMPR1B	1.94240379
15	ADRBK2	1.66666377
16	CSNK1G1	1.65939725
17	CSNK1G3	1.59259251
18	MARK1	1.57425684
19	MAP2K7	1.53962634
20	TNIK	1.52951674
21	ACVR1B	1.52065135
22	GRK1	1.51903205
23	CSNK1A1L	1.51717653
24	STK3	1.48356960
25	ZAK	1.44733263
26	MAPK13	1.43273981
27	EIF2AK3	1.42210323
28	CSNK1G2	1.41993390
29	CDK19	1.38347767
30	NTRK3	1.37879939
31	NUAK1	1.32439068
32	PLK2	1.27721775
33	PAK3	1.18907572
34	PTK2B	1.13940496
35	MAPK15	1.12714504
36	EIF2AK1	1.10861254
37	EPHA4	1.09185465
38	WNK4	1.07420669
39	MKNK2	1.01480008
40	RPS6KA4	0.98763876
41	INSRR	0.96942598
42	MINK1	0.95510091
43	PRKCG	0.94554319
44	PRKCE	0.94179624
45	SIK3	0.93765821
46	AKT3	0.91568511
47	NEK2	0.90769904
48	PHKG2	0.86473075
49	PHKG1	0.86473075
50	DYRK3	0.84121324
51	GRK7	0.82938461
52	ADRBK1	0.82513485
53	DAPK2	0.79729766
54	FGFR2	0.78015972
55	STK16	0.74401559
56	PLK3	0.72428835
57	DYRK2	0.70544431
58	PLK4	0.67369556
59	MAP2K4	0.64173653
60	TXK	0.62286307
61	CAMK2A	0.62134816
62	DYRK1A	0.58720357
63	OXSR1	0.57023695
64	PRKCI	0.53553376
65	KSR1	0.50347986
66	UHMK1	0.49512910
67	CSNK1A1	0.46858224
68	EIF2AK2	0.46013200
69	RPS6KA5	0.45935603
70	CDK5	0.45235561
71	STK39	0.45139004
72	CSNK1D	0.44896548
73	MST4	0.44467794
74	LIMK1	0.43876697
75	EPHA3	0.43447519
76	PLK1	0.41929816
77	CDK3	0.41660623
78	OBSCN	0.41403363
79	MAP3K5	0.40625566
80	ATM	0.40572035
81	NLK	0.40561819
82	BMPR2	0.39793298
83	PRKAA1	0.39024796
84	MAP3K6	0.38543786
85	SGK2	0.38495865
86	TSSK6	0.38379215
87	FER	0.37152943
88	PKN1	0.35755547
89	BRSK2	0.35699520
90	PRKACA	0.34872774
91	GRK5	0.33996029
92	MAP2K6	0.33300821
93	PRKG1	0.33288422
94	LATS1	0.33050039
95	MKNK1	0.32834374
96	SGK494	0.29391926
97	SGK223	0.29391926
98	RAF1	0.27851264
99	MARK3	0.27129280
100	NTRK2	0.26540857

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.56494675
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.50427295
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.33969679
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.92183456
5	Butanoate metabolism_Homo sapiens_hsa00650	2.84462996
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.73326815
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.67208242
8	Phototransduction_Homo sapiens_hsa04744	2.53767287
9	Nicotine addiction_Homo sapiens_hsa05033	2.27558416
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.21482229
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.18413244
12	Regulation of autophagy_Homo sapiens_hsa04140	1.84056058
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80813846
14	Propanoate metabolism_Homo sapiens_hsa00640	1.80217458
15	Basal transcription factors_Homo sapiens_hsa03022	1.76523717
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64299161
17	Peroxisome_Homo sapiens_hsa04146	1.63364119
18	GABAergic synapse_Homo sapiens_hsa04727	1.59936041
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.59089498
20	RNA degradation_Homo sapiens_hsa03018	1.54978996
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42964268
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.39254761
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.38843179
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.38629171
25	Circadian rhythm_Homo sapiens_hsa04710	1.36424519
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.26510003
27	Taste transduction_Homo sapiens_hsa04742	1.25309850
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.24460171
29	Morphine addiction_Homo sapiens_hsa05032	1.23202212
30	Folate biosynthesis_Homo sapiens_hsa00790	1.22166300
31	Insulin secretion_Homo sapiens_hsa04911	1.16507121
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.14785917
33	RNA polymerase_Homo sapiens_hsa03020	1.14166379
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.13219502
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13026272
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.11655122
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.10085867
38	Circadian entrainment_Homo sapiens_hsa04713	1.06915291
39	Fatty acid elongation_Homo sapiens_hsa00062	1.04671766
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.04573526
41	Olfactory transduction_Homo sapiens_hsa04740	1.04003460
42	Parkinsons disease_Homo sapiens_hsa05012	1.01345222
43	Glutamatergic synapse_Homo sapiens_hsa04724	0.99641738
44	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99622350
45	Purine metabolism_Homo sapiens_hsa00230	0.92924293
46	Non-homologous end-joining_Homo sapiens_hsa03450	0.92627173
47	p53 signaling pathway_Homo sapiens_hsa04115	0.91219167
48	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.87534226
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.86671446
50	Dopaminergic synapse_Homo sapiens_hsa04728	0.86376771
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84452060
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.83847157
53	Serotonergic synapse_Homo sapiens_hsa04726	0.83646720
54	Renin secretion_Homo sapiens_hsa04924	0.83120637
55	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.82127298
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77468885
57	Oocyte meiosis_Homo sapiens_hsa04114	0.74821306
58	Huntingtons disease_Homo sapiens_hsa05016	0.74580364
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.73961235
60	ABC transporters_Homo sapiens_hsa02010	0.70737705
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.69656080
62	Amphetamine addiction_Homo sapiens_hsa05031	0.68339916
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.65956052
64	Long-term depression_Homo sapiens_hsa04730	0.65020583
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64151300
66	Metabolic pathways_Homo sapiens_hsa01100	0.64063770
67	Proteasome_Homo sapiens_hsa03050	0.63789981
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63631029
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.60275466
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60127892
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59851881
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59627446
73	Legionellosis_Homo sapiens_hsa05134	0.58177518
74	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57562529
75	RNA transport_Homo sapiens_hsa03013	0.55956741
76	Alzheimers disease_Homo sapiens_hsa05010	0.54722007
77	Sulfur metabolism_Homo sapiens_hsa00920	0.54472183
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54465281
79	Salivary secretion_Homo sapiens_hsa04970	0.52564539
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48189686
81	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.47402014
82	Cocaine addiction_Homo sapiens_hsa05030	0.46161863
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45094332
84	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.43281671
85	Retinol metabolism_Homo sapiens_hsa00830	0.42946617
86	Glutathione metabolism_Homo sapiens_hsa00480	0.40809069
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40654959
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.40551609
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40107497
90	Caffeine metabolism_Homo sapiens_hsa00232	0.39648649
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.39583721
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.38861113
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.38640918
94	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.38067001
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37394786
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.36682422
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.35239345
98	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34264017
99	Type I diabetes mellitus_Homo sapiens_hsa04940	0.33673690
100	Vibrio cholerae infection_Homo sapiens_hsa05110	0.33641063

ZNF23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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