

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.13325470 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 4.89824349 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.49701771 |
| 4 | chromatin remodeling at centromere (GO:0031055) | 4.44573126 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.41233457 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 4.41233457 |
| 7 | CENP-A containing nucleosome assembly (GO:0034080) | 4.17341772 |
| 8 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.98894226 |
| 9 | establishment of integrated proviral latency (GO:0075713) | 3.88204089 |
| 10 | protein complex biogenesis (GO:0070271) | 3.81532357 |
| 11 | cullin deneddylation (GO:0010388) | 3.79476610 |
| 12 | DNA double-strand break processing (GO:0000729) | 3.78806371 |
| 13 | proteasome assembly (GO:0043248) | 3.70693958 |
| 14 | respiratory electron transport chain (GO:0022904) | 3.66792737 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.66139282 |
| 16 | regulation of mitochondrial translation (GO:0070129) | 3.65022221 |
| 17 | respiratory chain complex IV assembly (GO:0008535) | 3.62550625 |
| 18 | protein deneddylation (GO:0000338) | 3.62032346 |
| 19 | electron transport chain (GO:0022900) | 3.59216221 |
| 20 | histone exchange (GO:0043486) | 3.58879391 |
| 21 | DNA damage response, detection of DNA damage (GO:0042769) | 3.57718570 |
| 22 | ribosomal small subunit assembly (GO:0000028) | 3.57589534 |
| 23 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.57013002 |
| 24 | termination of RNA polymerase III transcription (GO:0006386) | 3.56225525 |
| 25 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.56225525 |
| 26 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.56082289 |
| 27 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.56082289 |
| 28 | NADH dehydrogenase complex assembly (GO:0010257) | 3.56082289 |
| 29 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.49696715 |
| 30 | protein neddylation (GO:0045116) | 3.47803642 |
| 31 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.44878253 |
| 32 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.39644502 |
| 33 | regulation of helicase activity (GO:0051095) | 3.37346354 |
| 34 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.33121766 |
| 35 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.32774771 |
| 36 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.31005843 |
| 37 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.31005843 |
| 38 | DNA strand elongation (GO:0022616) | 3.30621407 |
| 39 | DNA replication checkpoint (GO:0000076) | 3.30257288 |
| 40 | rRNA modification (GO:0000154) | 3.28074384 |
| 41 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.26357915 |
| 42 | DNA replication-independent nucleosome organization (GO:0034724) | 3.26357915 |
| 43 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.25927362 |
| 44 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.25927362 |
| 45 | cytochrome complex assembly (GO:0017004) | 3.24771781 |
| 46 | negative regulation of ligase activity (GO:0051352) | 3.21087776 |
| 47 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.21087776 |
| 48 | spliceosomal snRNP assembly (GO:0000387) | 3.20573852 |
| 49 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.20215945 |
| 50 | pseudouridine synthesis (GO:0001522) | 3.19465514 |
| 51 | maturation of SSU-rRNA (GO:0030490) | 3.18304693 |
| 52 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.17496002 |
| 53 | DNA ligation (GO:0006266) | 3.14784961 |
| 54 | resolution of meiotic recombination intermediates (GO:0000712) | 3.13106985 |
| 55 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.12422889 |
| 56 | replication fork processing (GO:0031297) | 3.08425448 |
| 57 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.06938463 |
| 58 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.06938463 |
| 59 | protein targeting to mitochondrion (GO:0006626) | 3.05986781 |
| 60 | establishment of viral latency (GO:0019043) | 3.02891552 |
| 61 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.01803057 |
| 62 | establishment of protein localization to mitochondrion (GO:0072655) | 2.96682958 |
| 63 | mitotic metaphase plate congression (GO:0007080) | 2.94123007 |
| 64 | protein localization to mitochondrion (GO:0070585) | 2.93937128 |
| 65 | purine nucleobase biosynthetic process (GO:0009113) | 2.92850243 |
| 66 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.83991675 |
| 67 | translational termination (GO:0006415) | 2.83294498 |
| 68 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.82952531 |
| 69 | mismatch repair (GO:0006298) | 2.82717253 |
| 70 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.81803262 |
| 71 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.78942547 |
| 72 | viral transcription (GO:0019083) | 2.78707634 |
| 73 | nucleobase biosynthetic process (GO:0046112) | 2.78130859 |
| 74 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.77892549 |
| 75 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.77892549 |
| 76 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.77892549 |
| 77 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.76307833 |
| 78 | kinetochore assembly (GO:0051382) | 2.76099796 |
| 79 | L-serine metabolic process (GO:0006563) | 2.76055317 |
| 80 | protein K6-linked ubiquitination (GO:0085020) | 2.75971800 |
| 81 | translation (GO:0006412) | 2.75751934 |
| 82 | telomere maintenance via recombination (GO:0000722) | 2.73654375 |
| 83 | negative regulation of DNA recombination (GO:0045910) | 2.73630302 |
| 84 | cotranslational protein targeting to membrane (GO:0006613) | 2.73429526 |
| 85 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.73301543 |
| 86 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.73301543 |
| 87 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.72703598 |
| 88 | sequestering of actin monomers (GO:0042989) | 2.72314345 |
| 89 | synapsis (GO:0007129) | 2.71637289 |
| 90 | IMP biosynthetic process (GO:0006188) | 2.71055897 |
| 91 | metaphase plate congression (GO:0051310) | 2.70236845 |
| 92 | inner mitochondrial membrane organization (GO:0007007) | 2.69634558 |
| 93 | postreplication repair (GO:0006301) | 2.69126580 |
| 94 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.68632225 |
| 95 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.68168092 |
| 96 | positive regulation of ligase activity (GO:0051351) | 2.68128284 |
| 97 | base-excision repair, AP site formation (GO:0006285) | 2.67829047 |
| 98 | histone mRNA metabolic process (GO:0008334) | 2.67703894 |
| 99 | ribosomal small subunit biogenesis (GO:0042274) | 2.66524209 |
| 100 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.66176045 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.83592917 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.37342998 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.15459128 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.08270173 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.93296036 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.24003222 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.23714098 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.07220469 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.00290726 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.99195768 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.93952077 |
| 12 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.92593158 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.82106840 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.67878252 |
| 15 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.57079076 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.48767977 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.47890228 |
| 18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.23398914 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.19485351 |
| 20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.19126020 |
| 21 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.16018491 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.11326679 |
| 23 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.05809851 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.05003264 |
| 25 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.98624890 |
| 26 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.87614541 |
| 27 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.86054361 |
| 28 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.84370012 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.83052384 |
| 30 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.77139185 |
| 31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.75338126 |
| 32 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.74668110 |
| 33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.74307395 |
| 34 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.73108655 |
| 35 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.72910827 |
| 36 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.72820160 |
| 37 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.72577371 |
| 38 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.71880597 |
| 39 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.71048025 |
| 40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.70711590 |
| 41 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.69161087 |
| 42 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.68932674 |
| 43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.67215744 |
| 44 | EWS_26573619_Chip-Seq_HEK293_Human | 1.64716336 |
| 45 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.64397645 |
| 46 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.61567956 |
| 47 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.55678793 |
| 48 | VDR_22108803_ChIP-Seq_LS180_Human | 1.55344034 |
| 49 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.52893576 |
| 50 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.52679805 |
| 51 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.52127674 |
| 52 | FUS_26573619_Chip-Seq_HEK293_Human | 1.52087024 |
| 53 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.49474384 |
| 54 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.43081119 |
| 55 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.39209525 |
| 56 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.37798078 |
| 57 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.37084471 |
| 58 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.35441758 |
| 59 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.33488056 |
| 60 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.31838735 |
| 61 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.27234010 |
| 62 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.24748705 |
| 63 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.23233794 |
| 64 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.21433020 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.19858959 |
| 66 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.12285417 |
| 67 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.10368250 |
| 68 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.01463883 |
| 69 | P300_19829295_ChIP-Seq_ESCs_Human | 1.00126214 |
| 70 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.99854480 |
| 71 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.99704115 |
| 72 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.98852473 |
| 73 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.98232048 |
| 74 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.97707016 |
| 75 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96698803 |
| 76 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.95020246 |
| 77 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.94779045 |
| 78 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.94539007 |
| 79 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.92164624 |
| 80 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.89389457 |
| 81 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.88859175 |
| 82 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.87714890 |
| 83 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.87561060 |
| 84 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.86807140 |
| 85 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.84967915 |
| 86 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.84489395 |
| 87 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.83887999 |
| 88 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.83864756 |
| 89 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.83697761 |
| 90 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.81007856 |
| 91 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.80879693 |
| 92 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.80778230 |
| 93 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.80451402 |
| 94 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.80249163 |
| 95 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.79235780 |
| 96 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.77702647 |
| 97 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.74238058 |
| 98 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.73685609 |
| 99 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.73445417 |
| 100 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.69125269 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.45165824 |
| 2 | MP0006292_abnormal_olfactory_placode | 3.34076644 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.16934686 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.03768503 |
| 5 | MP0003693_abnormal_embryo_hatching | 2.81275792 |
| 6 | MP0008789_abnormal_olfactory_epithelium | 2.64198376 |
| 7 | MP0002102_abnormal_ear_morphology | 2.44224856 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.42908473 |
| 9 | MP0003111_abnormal_nucleus_morphology | 2.23181757 |
| 10 | MP0005394_taste/olfaction_phenotype | 2.19167058 |
| 11 | MP0005499_abnormal_olfactory_system | 2.19167058 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.14884486 |
| 13 | MP0001529_abnormal_vocalization | 2.11844517 |
| 14 | MP0006072_abnormal_retinal_apoptosis | 2.08509026 |
| 15 | MP0002938_white_spotting | 2.07234879 |
| 16 | MP0001293_anophthalmia | 2.01070832 |
| 17 | MP0009379_abnormal_foot_pigmentation | 1.99992091 |
| 18 | MP0003136_yellow_coat_color | 1.98620605 |
| 19 | MP0003718_maternal_effect | 1.97031571 |
| 20 | MP0001188_hyperpigmentation | 1.91178641 |
| 21 | MP0003121_genomic_imprinting | 1.89190778 |
| 22 | MP0002653_abnormal_ependyma_morphology | 1.83004449 |
| 23 | MP0003077_abnormal_cell_cycle | 1.78426972 |
| 24 | MP0009697_abnormal_copulation | 1.74569415 |
| 25 | MP0004133_heterotaxia | 1.73540200 |
| 26 | MP0003941_abnormal_skin_development | 1.66680336 |
| 27 | MP0005084_abnormal_gallbladder_morpholo | 1.63282102 |
| 28 | MP0001984_abnormal_olfaction | 1.58876803 |
| 29 | MP0003880_abnormal_central_pattern | 1.58005315 |
| 30 | MP0003122_maternal_imprinting | 1.57166723 |
| 31 | MP0003787_abnormal_imprinting | 1.55999009 |
| 32 | MP0010030_abnormal_orbit_morphology | 1.53202846 |
| 33 | MP0003786_premature_aging | 1.42511574 |
| 34 | MP0008007_abnormal_cellular_replicative | 1.42428382 |
| 35 | MP0003567_abnormal_fetal_cardiomyocyte | 1.40622479 |
| 36 | MP0006276_abnormal_autonomic_nervous | 1.39297430 |
| 37 | MP0008057_abnormal_DNA_replication | 1.39068700 |
| 38 | MP0000049_abnormal_middle_ear | 1.38894674 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.38741047 |
| 40 | MP0003119_abnormal_digestive_system | 1.37655289 |
| 41 | MP0000631_abnormal_neuroendocrine_gland | 1.36242084 |
| 42 | MP0003890_abnormal_embryonic-extraembry | 1.36209608 |
| 43 | MP0008995_early_reproductive_senescence | 1.35611110 |
| 44 | MP0002751_abnormal_autonomic_nervous | 1.33112984 |
| 45 | MP0006036_abnormal_mitochondrial_physio | 1.29810456 |
| 46 | MP0005253_abnormal_eye_physiology | 1.26685743 |
| 47 | MP0002210_abnormal_sex_determination | 1.24342656 |
| 48 | MP0002638_abnormal_pupillary_reflex | 1.22554692 |
| 49 | MP0003123_paternal_imprinting | 1.21346502 |
| 50 | MP0003011_delayed_dark_adaptation | 1.21318487 |
| 51 | MP0003186_abnormal_redox_activity | 1.20750474 |
| 52 | MP0002233_abnormal_nose_morphology | 1.19914649 |
| 53 | MP0003937_abnormal_limbs/digits/tail_de | 1.18416395 |
| 54 | MP0005551_abnormal_eye_electrophysiolog | 1.15943472 |
| 55 | MP0001929_abnormal_gametogenesis | 1.14636706 |
| 56 | MP0001286_abnormal_eye_development | 1.14253315 |
| 57 | MP0000566_synostosis | 1.09068960 |
| 58 | MP0000778_abnormal_nervous_system | 1.08999033 |
| 59 | MP0000653_abnormal_sex_gland | 1.06535919 |
| 60 | MP0001145_abnormal_male_reproductive | 1.05390868 |
| 61 | MP0003938_abnormal_ear_development | 1.03240733 |
| 62 | MP0002234_abnormal_pharynx_morphology | 1.02398410 |
| 63 | MP0000372_irregular_coat_pigmentation | 1.01742457 |
| 64 | MP0002736_abnormal_nociception_after | 1.00965870 |
| 65 | MP0002822_catalepsy | 1.00733501 |
| 66 | MP0002277_abnormal_respiratory_mucosa | 1.00270012 |
| 67 | MP0003698_abnormal_male_reproductive | 0.99422183 |
| 68 | MP0004147_increased_porphyrin_level | 0.99036281 |
| 69 | MP0003806_abnormal_nucleotide_metabolis | 0.95653020 |
| 70 | MP0005391_vision/eye_phenotype | 0.94821816 |
| 71 | MP0001485_abnormal_pinna_reflex | 0.92135557 |
| 72 | MP0002160_abnormal_reproductive_system | 0.91840922 |
| 73 | MP0003315_abnormal_perineum_morphology | 0.91175773 |
| 74 | MP0002837_dystrophic_cardiac_calcinosis | 0.89205568 |
| 75 | MP0003283_abnormal_digestive_organ | 0.87784083 |
| 76 | MP0004142_abnormal_muscle_tone | 0.87596949 |
| 77 | MP0002085_abnormal_embryonic_tissue | 0.86411343 |
| 78 | MP0003861_abnormal_nervous_system | 0.85807250 |
| 79 | MP0001764_abnormal_homeostasis | 0.85651398 |
| 80 | MP0002697_abnormal_eye_size | 0.84811686 |
| 81 | MP0002184_abnormal_innervation | 0.84740758 |
| 82 | MP0009046_muscle_twitch | 0.83521249 |
| 83 | MP0005389_reproductive_system_phenotype | 0.82342910 |
| 84 | MP0001119_abnormal_female_reproductive | 0.81993626 |
| 85 | MP0005423_abnormal_somatic_nervous | 0.81853919 |
| 86 | MP0002752_abnormal_somatic_nervous | 0.81535022 |
| 87 | MP0002084_abnormal_developmental_patter | 0.81410447 |
| 88 | MP0003195_calcinosis | 0.80812083 |
| 89 | MP0002090_abnormal_vision | 0.79483264 |
| 90 | MP0005195_abnormal_posterior_eye | 0.79204222 |
| 91 | MP0000647_abnormal_sebaceous_gland | 0.77644396 |
| 92 | MP0002111_abnormal_tail_morphology | 0.75359418 |
| 93 | MP0001697_abnormal_embryo_size | 0.74371605 |
| 94 | MP0000350_abnormal_cell_proliferation | 0.74013351 |
| 95 | MP0002272_abnormal_nervous_system | 0.72477703 |
| 96 | MP0005645_abnormal_hypothalamus_physiol | 0.71200820 |
| 97 | MP0000026_abnormal_inner_ear | 0.70929536 |
| 98 | MP0001919_abnormal_reproductive_system | 0.70300608 |
| 99 | MP0002163_abnormal_gland_morphology | 0.70056178 |
| 100 | MP0009672_abnormal_birth_weight | 0.69818727 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.08272274 |
| 2 | Abnormality of the labia minora (HP:0012880) | 3.73840286 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.71889050 |
| 4 | Acute encephalopathy (HP:0006846) | 3.66730131 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.63546585 |
| 6 | Colon cancer (HP:0003003) | 3.60648632 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 3.42942248 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.36405666 |
| 9 | Increased CSF lactate (HP:0002490) | 3.31249780 |
| 10 | Hepatocellular necrosis (HP:0001404) | 3.21732263 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.19044453 |
| 12 | Hepatic necrosis (HP:0002605) | 2.93091669 |
| 13 | Hyperglycinemia (HP:0002154) | 2.91048317 |
| 14 | Reticulocytopenia (HP:0001896) | 2.88165898 |
| 15 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.71448996 |
| 16 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.71448996 |
| 17 | Renal Fanconi syndrome (HP:0001994) | 2.70745691 |
| 18 | Cerebral edema (HP:0002181) | 2.70536647 |
| 19 | Meckel diverticulum (HP:0002245) | 2.70372537 |
| 20 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.66053198 |
| 21 | Abnormal number of erythroid precursors (HP:0012131) | 2.61072488 |
| 22 | Septo-optic dysplasia (HP:0100842) | 2.58185439 |
| 23 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.58153134 |
| 24 | Abnormality of the ileum (HP:0001549) | 2.57045322 |
| 25 | Methylmalonic acidemia (HP:0002912) | 2.56919659 |
| 26 | True hermaphroditism (HP:0010459) | 2.48310273 |
| 27 | Pancreatic cysts (HP:0001737) | 2.48147904 |
| 28 | Medial flaring of the eyebrow (HP:0010747) | 2.44950535 |
| 29 | Pancreatic fibrosis (HP:0100732) | 2.42047146 |
| 30 | Nephronophthisis (HP:0000090) | 2.41586677 |
| 31 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.38517522 |
| 32 | Increased intramyocellular lipid droplets (HP:0012240) | 2.36040175 |
| 33 | Increased serum lactate (HP:0002151) | 2.31678119 |
| 34 | Congenital primary aphakia (HP:0007707) | 2.28519642 |
| 35 | 3-Methylglutaconic aciduria (HP:0003535) | 2.28293807 |
| 36 | Lactic acidosis (HP:0003128) | 2.27894492 |
| 37 | Gait imbalance (HP:0002141) | 2.26928050 |
| 38 | Macrocytic anemia (HP:0001972) | 2.26173626 |
| 39 | Molar tooth sign on MRI (HP:0002419) | 2.24602939 |
| 40 | Abnormality of midbrain morphology (HP:0002418) | 2.24602939 |
| 41 | Abnormal lung lobation (HP:0002101) | 2.20809706 |
| 42 | Chromsome breakage (HP:0040012) | 2.20126339 |
| 43 | Methylmalonic aciduria (HP:0012120) | 2.18124095 |
| 44 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.14624754 |
| 45 | Abnormality of the preputium (HP:0100587) | 2.14425907 |
| 46 | Nephrogenic diabetes insipidus (HP:0009806) | 2.11682392 |
| 47 | Ependymoma (HP:0002888) | 2.08740111 |
| 48 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.08034255 |
| 49 | Abnormality of glycine metabolism (HP:0010895) | 2.08034255 |
| 50 | Respiratory failure (HP:0002878) | 2.06989685 |
| 51 | Abnormality of chromosome stability (HP:0003220) | 2.04877561 |
| 52 | Optic disc pallor (HP:0000543) | 2.04522347 |
| 53 | Pendular nystagmus (HP:0012043) | 2.03987975 |
| 54 | Triphalangeal thumb (HP:0001199) | 2.01829441 |
| 55 | Leukodystrophy (HP:0002415) | 2.01490291 |
| 56 | Hyperglycinuria (HP:0003108) | 2.00531810 |
| 57 | Medulloblastoma (HP:0002885) | 1.99397964 |
| 58 | Horseshoe kidney (HP:0000085) | 1.98549395 |
| 59 | Cerebral hypomyelination (HP:0006808) | 1.97931391 |
| 60 | Sclerocornea (HP:0000647) | 1.95941598 |
| 61 | Absent septum pellucidum (HP:0001331) | 1.94678437 |
| 62 | Vaginal atresia (HP:0000148) | 1.94538894 |
| 63 | Abnormality of serum amino acid levels (HP:0003112) | 1.94083558 |
| 64 | Supernumerary spleens (HP:0009799) | 1.93809995 |
| 65 | Exertional dyspnea (HP:0002875) | 1.93242029 |
| 66 | Exercise intolerance (HP:0003546) | 1.92762350 |
| 67 | Genital tract atresia (HP:0001827) | 1.91032814 |
| 68 | Abnormality of the anterior horn cell (HP:0006802) | 1.90567366 |
| 69 | Degeneration of anterior horn cells (HP:0002398) | 1.90567366 |
| 70 | Increased muscle lipid content (HP:0009058) | 1.88639467 |
| 71 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.87356647 |
| 72 | Male pseudohermaphroditism (HP:0000037) | 1.84892585 |
| 73 | Microvesicular hepatic steatosis (HP:0001414) | 1.83780729 |
| 74 | Type I transferrin isoform profile (HP:0003642) | 1.82508520 |
| 75 | Bilateral microphthalmos (HP:0007633) | 1.81550281 |
| 76 | Lethargy (HP:0001254) | 1.81538757 |
| 77 | Multiple enchondromatosis (HP:0005701) | 1.80368155 |
| 78 | Duodenal stenosis (HP:0100867) | 1.80305395 |
| 79 | Small intestinal stenosis (HP:0012848) | 1.80305395 |
| 80 | Abnormality of the septum pellucidum (HP:0007375) | 1.77484058 |
| 81 | Intestinal atresia (HP:0011100) | 1.77210509 |
| 82 | Sloping forehead (HP:0000340) | 1.76883912 |
| 83 | Anencephaly (HP:0002323) | 1.76558826 |
| 84 | Abnormality of the renal medulla (HP:0100957) | 1.76552432 |
| 85 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.74912730 |
| 86 | Abnormality of the duodenum (HP:0002246) | 1.74558407 |
| 87 | Hypoglycemic seizures (HP:0002173) | 1.73951747 |
| 88 | Absent thumb (HP:0009777) | 1.72818942 |
| 89 | Hypoplasia of the pons (HP:0012110) | 1.72700767 |
| 90 | Abnormality of renal resorption (HP:0011038) | 1.72573307 |
| 91 | Respiratory difficulties (HP:0002880) | 1.72565979 |
| 92 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.72068945 |
| 93 | Increased serum pyruvate (HP:0003542) | 1.68630309 |
| 94 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.67914526 |
| 95 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.66515030 |
| 96 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.66515030 |
| 97 | Abnormal protein glycosylation (HP:0012346) | 1.66515030 |
| 98 | Abnormal glycosylation (HP:0012345) | 1.66515030 |
| 99 | Stenosis of the external auditory canal (HP:0000402) | 1.65906917 |
| 100 | Preaxial hand polydactyly (HP:0001177) | 1.65612499 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.58032140 |
| 2 | CDC7 | 3.51257960 |
| 3 | BUB1 | 3.47063372 |
| 4 | SRPK1 | 3.16966139 |
| 5 | WNK3 | 2.99524931 |
| 6 | ZAK | 2.84303320 |
| 7 | PLK4 | 2.42141155 |
| 8 | PBK | 2.41787874 |
| 9 | STK16 | 2.34142154 |
| 10 | VRK1 | 2.30205621 |
| 11 | NUAK1 | 2.10892456 |
| 12 | DYRK2 | 2.07995490 |
| 13 | PLK3 | 2.06879713 |
| 14 | TTK | 2.00129398 |
| 15 | NME1 | 1.98907784 |
| 16 | TSSK6 | 1.97185730 |
| 17 | MAP3K4 | 1.89510956 |
| 18 | TRIM28 | 1.83129468 |
| 19 | MAP4K2 | 1.81310459 |
| 20 | MAP2K7 | 1.61067087 |
| 21 | PLK1 | 1.57104360 |
| 22 | TNIK | 1.50858022 |
| 23 | WEE1 | 1.49887600 |
| 24 | NEK1 | 1.47942642 |
| 25 | MKNK2 | 1.46492840 |
| 26 | MKNK1 | 1.43382177 |
| 27 | PNCK | 1.36654929 |
| 28 | BCKDK | 1.34420279 |
| 29 | BRSK2 | 1.30987511 |
| 30 | MST4 | 1.30078846 |
| 31 | ATR | 1.28229292 |
| 32 | CSNK1G1 | 1.27983947 |
| 33 | CSNK1G3 | 1.25810349 |
| 34 | TAF1 | 1.25237172 |
| 35 | CSNK1G2 | 1.19946785 |
| 36 | DYRK3 | 1.16935389 |
| 37 | EIF2AK3 | 1.13201300 |
| 38 | EIF2AK1 | 1.12067768 |
| 39 | BCR | 1.09729908 |
| 40 | GRK1 | 1.09548053 |
| 41 | PASK | 1.05222717 |
| 42 | TLK1 | 1.04965756 |
| 43 | AURKB | 1.03462885 |
| 44 | BMPR1B | 1.02568253 |
| 45 | LATS1 | 1.00916733 |
| 46 | PLK2 | 1.00122973 |
| 47 | CASK | 0.98607425 |
| 48 | CSNK1A1L | 0.98021432 |
| 49 | BRSK1 | 0.94898786 |
| 50 | CHEK2 | 0.94371572 |
| 51 | CDK19 | 0.92469430 |
| 52 | AURKA | 0.86356521 |
| 53 | PINK1 | 0.85438656 |
| 54 | INSRR | 0.83782962 |
| 55 | CCNB1 | 0.78598903 |
| 56 | RPS6KA4 | 0.77947855 |
| 57 | NME2 | 0.77743274 |
| 58 | ATM | 0.75101508 |
| 59 | CDK3 | 0.74234813 |
| 60 | ADRBK2 | 0.73015311 |
| 61 | MAPK13 | 0.72987022 |
| 62 | PRKCG | 0.70016861 |
| 63 | PDK2 | 0.64347313 |
| 64 | ERBB3 | 0.63514577 |
| 65 | CSNK2A2 | 0.63403759 |
| 66 | CSNK2A1 | 0.63034660 |
| 67 | NEK2 | 0.61763565 |
| 68 | STK38L | 0.61713547 |
| 69 | MINK1 | 0.60853072 |
| 70 | ACVR1B | 0.58902976 |
| 71 | RPS6KA5 | 0.58589565 |
| 72 | FRK | 0.58517281 |
| 73 | CSNK1E | 0.57547937 |
| 74 | CHEK1 | 0.56999384 |
| 75 | MAP3K12 | 0.56157599 |
| 76 | KDR | 0.55469871 |
| 77 | TIE1 | 0.51380138 |
| 78 | EPHA4 | 0.50942712 |
| 79 | MARK1 | 0.50697375 |
| 80 | STK4 | 0.46945988 |
| 81 | OXSR1 | 0.44585494 |
| 82 | MAPK15 | 0.43834127 |
| 83 | CSNK1A1 | 0.42738756 |
| 84 | CDK1 | 0.41235705 |
| 85 | PRKDC | 0.40803877 |
| 86 | DAPK1 | 0.40402795 |
| 87 | WNK4 | 0.39911711 |
| 88 | CDK2 | 0.39723380 |
| 89 | CDK7 | 0.38006924 |
| 90 | OBSCN | 0.37888720 |
| 91 | EIF2AK2 | 0.37642764 |
| 92 | NTRK2 | 0.36201328 |
| 93 | UHMK1 | 0.33766550 |
| 94 | IRAK2 | 0.33680709 |
| 95 | STK3 | 0.32462852 |
| 96 | ERBB4 | 0.31591944 |
| 97 | PKN1 | 0.29922699 |
| 98 | TESK2 | 0.29758034 |
| 99 | CDK14 | 0.29195068 |
| 100 | FGFR2 | 0.28001295 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.67045004 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.40410014 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.32986199 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.20013533 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 3.16027488 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.03576261 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 3.02463444 |
| 8 | Protein export_Homo sapiens_hsa03060 | 2.63822668 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.39387105 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.38640164 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.26018827 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.25437903 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.16693700 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.12963818 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 2.02471167 |
| 16 | Alzheimers disease_Homo sapiens_hsa05010 | 1.92704452 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.86131135 |
| 18 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.85689490 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.81111132 |
| 20 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.77042141 |
| 21 | RNA transport_Homo sapiens_hsa03013 | 1.76506984 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.69191668 |
| 23 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.67883340 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.66877124 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.66615925 |
| 26 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.60131018 |
| 27 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.57810350 |
| 28 | RNA degradation_Homo sapiens_hsa03018 | 1.57689688 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.50143449 |
| 30 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.49602885 |
| 31 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.42616183 |
| 32 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.39306087 |
| 33 | Cell cycle_Homo sapiens_hsa04110 | 1.34829915 |
| 34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.28389808 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.24927610 |
| 36 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.23834817 |
| 37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.21535507 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.20065346 |
| 39 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.13698023 |
| 40 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.13279471 |
| 41 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.02959164 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.00258967 |
| 43 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.96179768 |
| 44 | Phototransduction_Homo sapiens_hsa04744 | 0.92703691 |
| 45 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.90545608 |
| 46 | Sulfur relay system_Homo sapiens_hsa04122 | 0.88869598 |
| 47 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.85152173 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.83682795 |
| 49 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.82451319 |
| 50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.80158842 |
| 51 | Metabolic pathways_Homo sapiens_hsa01100 | 0.78037435 |
| 52 | Nicotine addiction_Homo sapiens_hsa05033 | 0.77623475 |
| 53 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.77109470 |
| 54 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.74752367 |
| 55 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.69799457 |
| 56 | Carbon metabolism_Homo sapiens_hsa01200 | 0.69335915 |
| 57 | Peroxisome_Homo sapiens_hsa04146 | 0.67562424 |
| 58 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.65352087 |
| 59 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.65227282 |
| 60 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.64873315 |
| 61 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.61310539 |
| 62 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.60810761 |
| 63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.57113575 |
| 64 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.55641071 |
| 65 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.55296150 |
| 66 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.51702547 |
| 67 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.50629576 |
| 68 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.50163811 |
| 69 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.50042066 |
| 70 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.47300298 |
| 71 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.47298216 |
| 72 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.44769240 |
| 73 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.43931657 |
| 74 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.42847921 |
| 75 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.42368195 |
| 76 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.41966254 |
| 77 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.41316044 |
| 78 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.39728738 |
| 79 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.38831310 |
| 80 | Retinol metabolism_Homo sapiens_hsa00830 | 0.38437642 |
| 81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.37026686 |
| 82 | Taste transduction_Homo sapiens_hsa04742 | 0.36229458 |
| 83 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.35693220 |
| 84 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.35648855 |
| 85 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.34620740 |
| 86 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34191902 |
| 87 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.33984028 |
| 88 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.31669824 |
| 89 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.31013359 |
| 90 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.30782024 |
| 91 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.29971133 |
| 92 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.28942182 |
| 93 | Alcoholism_Homo sapiens_hsa05034 | 0.24260971 |
| 94 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.22987072 |
| 95 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.21847065 |
| 96 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.21593438 |
| 97 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.21108648 |
| 98 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.19570371 |
| 99 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.19231430 |
| 100 | Olfactory transduction_Homo sapiens_hsa04740 | 0.19184100 |

