ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.52788607
2	behavioral response to nicotine (GO:0035095)	4.22829115
3	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.14465052
4	tryptophan catabolic process (GO:0006569)	4.02634576
5	indole-containing compound catabolic process (GO:0042436)	4.02634576
6	indolalkylamine catabolic process (GO:0046218)	4.02634576
7	kynurenine metabolic process (GO:0070189)	4.01787845
8	piRNA metabolic process (GO:0034587)	3.86355216
9	indolalkylamine metabolic process (GO:0006586)	3.76494532
10	behavioral response to ethanol (GO:0048149)	3.72076288
11	L-fucose metabolic process (GO:0042354)	3.62337426
12	L-fucose catabolic process (GO:0042355)	3.62337426
13	fucose catabolic process (GO:0019317)	3.62337426
14	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.57354916
15	protein K11-linked deubiquitination (GO:0035871)	3.56455674
16	neural tube formation (GO:0001841)	3.45876788
17	detection of light stimulus involved in visual perception (GO:0050908)	3.45004149
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.45004149
19	tryptophan metabolic process (GO:0006568)	3.39850258
20	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.36623296
21	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.33588442
22	regulation of meiosis I (GO:0060631)	3.26108122
23	ketone body metabolic process (GO:1902224)	3.18440642
24	centriole replication (GO:0007099)	3.16146557
25	auditory receptor cell stereocilium organization (GO:0060088)	3.15222606
26	gamma-aminobutyric acid transport (GO:0015812)	3.14906812
27	photoreceptor cell maintenance (GO:0045494)	3.11062501
28	pyrimidine nucleobase catabolic process (GO:0006208)	3.09174440
29	cellular ketone body metabolic process (GO:0046950)	3.08725273
30	DNA double-strand break processing (GO:0000729)	3.08680702
31	epithelial cilium movement (GO:0003351)	3.06528007
32	protein polyglutamylation (GO:0018095)	3.06457967
33	inner ear receptor stereocilium organization (GO:0060122)	3.03203948
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.02202747
35	reciprocal DNA recombination (GO:0035825)	2.96710830
36	reciprocal meiotic recombination (GO:0007131)	2.96710830
37	DNA methylation involved in gamete generation (GO:0043046)	2.92987017
38	indole-containing compound metabolic process (GO:0042430)	2.92580278
39	C4-dicarboxylate transport (GO:0015740)	2.91003851
40	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.89964038
41	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.89964038
42	axoneme assembly (GO:0035082)	2.88720969
43	L-methionine biosynthetic process (GO:0071265)	2.88662025
44	amino acid salvage (GO:0043102)	2.88662025
45	L-methionine salvage (GO:0071267)	2.88662025
46	prenylation (GO:0097354)	2.87047065
47	protein prenylation (GO:0018342)	2.87047065
48	recombinational repair (GO:0000725)	2.85288041
49	double-strand break repair via homologous recombination (GO:0000724)	2.84794240
50	meiotic chromosome segregation (GO:0045132)	2.84714062
51	protein localization to cilium (GO:0061512)	2.84526483
52	regulation of hippo signaling (GO:0035330)	2.83383516
53	cilium morphogenesis (GO:0060271)	2.83348322
54	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.80220561
55	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.76247967
56	cilium or flagellum-dependent cell motility (GO:0001539)	2.76235739
57	transmission of nerve impulse (GO:0019226)	2.73851815
58	negative regulation of mast cell activation (GO:0033004)	2.71936268
59	nucleobase catabolic process (GO:0046113)	2.71752377
60	DNA deamination (GO:0045006)	2.70803265
61	reflex (GO:0060004)	2.70776281
62	replication fork processing (GO:0031297)	2.70740891
63	photoreceptor cell development (GO:0042461)	2.70093453
64	platelet dense granule organization (GO:0060155)	2.68914720
65	male meiosis (GO:0007140)	2.66443613
66	tachykinin receptor signaling pathway (GO:0007217)	2.63795859
67	proline transport (GO:0015824)	2.62650371
68	nonmotile primary cilium assembly (GO:0035058)	2.62532486
69	cilium movement (GO:0003341)	2.61753426
70	regulation of action potential (GO:0098900)	2.61591137
71	regulation of cilium movement (GO:0003352)	2.61009452
72	methionine biosynthetic process (GO:0009086)	2.60242185
73	synapsis (GO:0007129)	2.60022208
74	cellular biogenic amine catabolic process (GO:0042402)	2.59490094
75	amine catabolic process (GO:0009310)	2.59490094
76	retinal cone cell development (GO:0046549)	2.59308044
77	cilium organization (GO:0044782)	2.58077859
78	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.56931634
79	cornea development in camera-type eye (GO:0061303)	2.56792125
80	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.56445072
81	central nervous system neuron axonogenesis (GO:0021955)	2.55992606
82	monoubiquitinated protein deubiquitination (GO:0035520)	2.55924837
83	neuronal action potential propagation (GO:0019227)	2.55034693
84	gene silencing by RNA (GO:0031047)	2.54954085
85	cilium assembly (GO:0042384)	2.54677274
86	water-soluble vitamin biosynthetic process (GO:0042364)	2.54423908
87	regulation of DNA endoreduplication (GO:0032875)	2.53147240
88	startle response (GO:0001964)	2.53022522
89	regulation of memory T cell differentiation (GO:0043380)	2.52233016
90	central nervous system projection neuron axonogenesis (GO:0021952)	2.51665992
91	neuronal action potential (GO:0019228)	2.51567642
92	signal peptide processing (GO:0006465)	2.51366318
93	acrosome assembly (GO:0001675)	2.51015787
94	sex differentiation (GO:0007548)	2.49622423
95	eye photoreceptor cell development (GO:0042462)	2.49150541
96	establishment of protein localization to Golgi (GO:0072600)	2.48026903
97	regulation of hexokinase activity (GO:1903299)	2.47976011
98	regulation of glucokinase activity (GO:0033131)	2.47976011
99	regulation of sarcomere organization (GO:0060297)	2.46840708
100	regulation of translation, ncRNA-mediated (GO:0045974)	2.44125717

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.76347786
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.31940156
3	VDR_22108803_ChIP-Seq_LS180_Human	3.18778398
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.08931697
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.06846199
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.78727248
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.65769786
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.65699662
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.50459126
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.49843618
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42026742
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37447031
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30408138
14	FUS_26573619_Chip-Seq_HEK293_Human	2.29443027
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.21434681
16	P300_19829295_ChIP-Seq_ESCs_Human	2.14463431
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.05154793
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.05114291
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01302561
20	EWS_26573619_Chip-Seq_HEK293_Human	1.97512246
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.96460164
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.87336017
23	STAT3_23295773_ChIP-Seq_U87_Human	1.84554031
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.78735193
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72757354
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.71298437
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70778371
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.70710058
29	TCF4_23295773_ChIP-Seq_U87_Human	1.68285262
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60301643
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60248108
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.60248108
33	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.57757819
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54986642
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52952673
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51568062
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51568062
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.51441305
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.50694237
40	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.50083670
41	AR_25329375_ChIP-Seq_VCAP_Human	1.49135920
42	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.48792416
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46698646
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46602427
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45638773
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44419944
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44362521
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42491418
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42056920
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.40146415
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39433439
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.39226979
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38233236
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37676669
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36206789
56	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34066994
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32931725
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31343237
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31343237
60	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30636780
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30327167
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.30232912
63	AR_21572438_ChIP-Seq_LNCaP_Human	1.29893280
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.29218494
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26578286
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23558939
67	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23518776
68	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23359272
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23224394
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20103037
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19604112
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16940490
73	CDX2_22108803_ChIP-Seq_LS180_Human	1.16836464
74	TP53_16413492_ChIP-PET_HCT116_Human	1.15089764
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14362840
76	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13783602
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11579758
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.11481020
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11373604
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09471359
81	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.09048101
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07822714
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07112398
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07112398
85	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.07000476
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05615682
87	P300_18555785_Chip-Seq_ESCs_Mouse	1.05106270
88	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04350355
89	NCOR_22424771_ChIP-Seq_293T_Human	1.04215125
90	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02656019
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01209714
92	KDM2B_26808549_Chip-Seq_REH_Human	1.00581468
93	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00226697
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99944151
95	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99905324
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99628376
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99580360
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98528405
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94769407
100	ELK1_19687146_ChIP-ChIP_HELA_Human	0.94429963

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.52340964
2	MP0003646_muscle_fatigue	3.00294985
3	MP0000372_irregular_coat_pigmentation	2.92639711
4	MP0008877_abnormal_DNA_methylation	2.92510015
5	MP0003195_calcinosis	2.64594806
6	MP0005551_abnormal_eye_electrophysiolog	2.63070251
7	MP0008057_abnormal_DNA_replication	2.59871163
8	MP0002102_abnormal_ear_morphology	2.47348681
9	MP0001968_abnormal_touch/_nociception	2.43649837
10	MP0003880_abnormal_central_pattern	2.20508977
11	MP0002837_dystrophic_cardiac_calcinosis	2.17815052
12	MP0002736_abnormal_nociception_after	2.16962517
13	MP0009046_muscle_twitch	2.11302148
14	MP0003136_yellow_coat_color	2.08504530
15	MP0005253_abnormal_eye_physiology	2.06216215
16	MP0004043_abnormal_pH_regulation	2.06188953
17	MP0001501_abnormal_sleep_pattern	1.91200235
18	MP0009745_abnormal_behavioral_response	1.88407360
19	MP0005174_abnormal_tail_pigmentation	1.85186181
20	MP0006292_abnormal_olfactory_placode	1.83965319
21	MP0005645_abnormal_hypothalamus_physiol	1.80843576
22	MP0006072_abnormal_retinal_apoptosis	1.72532915
23	MP0008058_abnormal_DNA_repair	1.72512439
24	MP0000427_abnormal_hair_cycle	1.69103691
25	MP0001486_abnormal_startle_reflex	1.68568826
26	MP0005075_abnormal_melanosome_morpholog	1.68137284
27	MP0003787_abnormal_imprinting	1.66167084
28	MP0001986_abnormal_taste_sensitivity	1.61127929
29	MP0005171_absent_coat_pigmentation	1.60251667
30	MP0002938_white_spotting	1.59561030
31	MP0005646_abnormal_pituitary_gland	1.59507194
32	MP0006276_abnormal_autonomic_nervous	1.56559262
33	MP0003252_abnormal_bile_duct	1.53855324
34	MP0008872_abnormal_physiological_respon	1.53304702
35	MP0001529_abnormal_vocalization	1.53160891
36	MP0000015_abnormal_ear_pigmentation	1.52876215
37	MP0001984_abnormal_olfaction	1.52118498
38	MP0002272_abnormal_nervous_system	1.49622879
39	MP0002095_abnormal_skin_pigmentation	1.43949672
40	MP0004147_increased_porphyrin_level	1.42653157
41	MP0004885_abnormal_endolymph	1.34276176
42	MP0002876_abnormal_thyroid_physiology	1.33712838
43	MP0002638_abnormal_pupillary_reflex	1.33387150
44	MP0000383_abnormal_hair_follicle	1.32075707
45	MP0001485_abnormal_pinna_reflex	1.30882749
46	MP0002064_seizures	1.30040017
47	MP0003718_maternal_effect	1.29991022
48	MP0000631_abnormal_neuroendocrine_gland	1.28793639
49	MP0004142_abnormal_muscle_tone	1.28153706
50	MP0005386_behavior/neurological_phenoty	1.26855666
51	MP0004924_abnormal_behavior	1.26855666
52	MP0004215_abnormal_myocardial_fiber	1.23111742
53	MP0008875_abnormal_xenobiotic_pharmacok	1.20951125
54	MP0002572_abnormal_emotion/affect_behav	1.20224689
55	MP0005083_abnormal_biliary_tract	1.19681480
56	MP0001324_abnormal_eye_pigmentation	1.15400600
57	MP0000371_diluted_coat_color	1.10791600
58	MP0005167_abnormal_blood-brain_barrier	1.10530704
59	MP0000778_abnormal_nervous_system	1.08891735
60	MP0002067_abnormal_sensory_capabilities	1.08703413
61	MP0002234_abnormal_pharynx_morphology	1.08101862
62	MP0003121_genomic_imprinting	1.07438752
63	MP0002735_abnormal_chemical_nociception	1.07116102
64	MP0004133_heterotaxia	1.06827819
65	MP0003635_abnormal_synaptic_transmissio	1.06717099
66	MP0002557_abnormal_social/conspecific_i	1.06609410
67	MP0004742_abnormal_vestibular_system	1.01998336
68	MP0003950_abnormal_plasma_membrane	0.99761419
69	MP0003698_abnormal_male_reproductive	0.98500240
70	MP0005670_abnormal_white_adipose	0.98356454
71	MP0005085_abnormal_gallbladder_physiolo	0.97658483
72	MP0002733_abnormal_thermal_nociception	0.96286882
73	MP0005410_abnormal_fertilization	0.96036107
74	MP0002751_abnormal_autonomic_nervous	0.93727252
75	MP0005195_abnormal_posterior_eye	0.91939963
76	MP0002063_abnormal_learning/memory/cond	0.90923073
77	MP0001970_abnormal_pain_threshold	0.90402616
78	MP0005408_hypopigmentation	0.89589520
79	MP0009697_abnormal_copulation	0.89566497
80	MP0002229_neurodegeneration	0.88777438
81	MP0000516_abnormal_urinary_system	0.87094427
82	MP0005367_renal/urinary_system_phenotyp	0.87094427
83	MP0002752_abnormal_somatic_nervous	0.86908664
84	MP0004145_abnormal_muscle_electrophysio	0.86710559
85	MP0001764_abnormal_homeostasis	0.86443503
86	MP0003011_delayed_dark_adaptation	0.86089555
87	MP0001929_abnormal_gametogenesis	0.82947851
88	MP0010094_abnormal_chromosome_stability	0.82520031
89	MP0006035_abnormal_mitochondrial_morpho	0.80828780
90	MP0002163_abnormal_gland_morphology	0.80224773
91	MP0005391_vision/eye_phenotype	0.79846480
92	MP0003137_abnormal_impulse_conducting	0.78765920
93	MP0002928_abnormal_bile_duct	0.76802750
94	MP0001963_abnormal_hearing_physiology	0.76706102
95	MP0002653_abnormal_ependyma_morphology	0.76663820
96	MP0002254_reproductive_system_inflammat	0.76631288
97	MP0005647_abnormal_sex_gland	0.76400637
98	MP0000026_abnormal_inner_ear	0.75011633
99	MP0005310_abnormal_salivary_gland	0.74950433
100	MP0002210_abnormal_sex_determination	0.74343581

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.35270850
2	Hyperventilation (HP:0002883)	4.01827408
3	Pancreatic fibrosis (HP:0100732)	3.95547093
4	Gaze-evoked nystagmus (HP:0000640)	3.89117551
5	True hermaphroditism (HP:0010459)	3.79202280
6	Molar tooth sign on MRI (HP:0002419)	3.73642384
7	Abnormality of midbrain morphology (HP:0002418)	3.73642384
8	Genetic anticipation (HP:0003743)	3.67480413
9	Nephronophthisis (HP:0000090)	3.56966372
10	Congenital stationary night blindness (HP:0007642)	3.54688394
11	Progressive cerebellar ataxia (HP:0002073)	3.31239182
12	Abnormality of the renal cortex (HP:0011035)	3.27679785
13	Abnormality of the renal medulla (HP:0100957)	3.22690454
14	Chronic hepatic failure (HP:0100626)	3.13503660
15	Pendular nystagmus (HP:0012043)	2.98223001
16	Medial flaring of the eyebrow (HP:0010747)	2.84723471
17	Type II lissencephaly (HP:0007260)	2.79338926
18	Abolished electroretinogram (ERG) (HP:0000550)	2.77059054
19	Absent speech (HP:0001344)	2.72993791
20	Attenuation of retinal blood vessels (HP:0007843)	2.71338927
21	Cystic liver disease (HP:0006706)	2.64763305
22	Inability to walk (HP:0002540)	2.63861549
23	Febrile seizures (HP:0002373)	2.61395521
24	Tubular atrophy (HP:0000092)	2.58984482
25	Focal seizures (HP:0007359)	2.52732919
26	Protruding tongue (HP:0010808)	2.50796552
27	Renal cortical cysts (HP:0000803)	2.49293471
28	Colon cancer (HP:0003003)	2.48875659
29	Progressive inability to walk (HP:0002505)	2.45196668
30	Fair hair (HP:0002286)	2.45028609
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.43008390
32	Keratoconus (HP:0000563)	2.42887503
33	Increased corneal curvature (HP:0100692)	2.42887503
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.41361968
35	Broad-based gait (HP:0002136)	2.39633617
36	Focal motor seizures (HP:0011153)	2.38798651
37	Decreased central vision (HP:0007663)	2.38676850
38	Dialeptic seizures (HP:0011146)	2.37534000
39	Sclerocornea (HP:0000647)	2.32280670
40	Abnormality of macular pigmentation (HP:0008002)	2.31977233
41	Congenital hepatic fibrosis (HP:0002612)	2.30572537
42	Postaxial foot polydactyly (HP:0001830)	2.30304282
43	Gait imbalance (HP:0002141)	2.28267637
44	Lissencephaly (HP:0001339)	2.28091977
45	Chorioretinal atrophy (HP:0000533)	2.27433441
46	Abnormality of alanine metabolism (HP:0010916)	2.23969708
47	Hyperalaninemia (HP:0003348)	2.23969708
48	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.23969708
49	Congenital primary aphakia (HP:0007707)	2.23434684
50	Cerebellar dysplasia (HP:0007033)	2.20053215
51	Anencephaly (HP:0002323)	2.18968639
52	Atonic seizures (HP:0010819)	2.16334852
53	Generalized hypopigmentation of hair (HP:0011358)	2.14662349
54	Drooling (HP:0002307)	2.11285466
55	Genital tract atresia (HP:0001827)	2.10370822
56	Nephrogenic diabetes insipidus (HP:0009806)	2.07630537
57	Intestinal atresia (HP:0011100)	2.07543745
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.06569410
59	Clumsiness (HP:0002312)	2.06226221
60	Chromsome breakage (HP:0040012)	2.06040258
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.03009369
62	Hypoplasia of the fovea (HP:0007750)	2.03009369
63	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.01606737
64	Tubulointerstitial nephritis (HP:0001970)	2.00876306
65	Hyperglycinemia (HP:0002154)	1.99333054
66	Abnormal rod and cone electroretinograms (HP:0008323)	1.96914473
67	Hemiparesis (HP:0001269)	1.95792276
68	Vaginal atresia (HP:0000148)	1.94355611
69	Congenital sensorineural hearing impairment (HP:0008527)	1.92894306
70	Astigmatism (HP:0000483)	1.92017307
71	Retinal dysplasia (HP:0007973)	1.91494364
72	Absence seizures (HP:0002121)	1.90689389
73	Volvulus (HP:0002580)	1.90420043
74	Small hand (HP:0200055)	1.90005607
75	Excessive salivation (HP:0003781)	1.86447562
76	Abnormal drinking behavior (HP:0030082)	1.86328435
77	Polydipsia (HP:0001959)	1.86328435
78	Bony spicule pigmentary retinopathy (HP:0007737)	1.85109139
79	Abnormality of the ileum (HP:0001549)	1.84883062
80	Preaxial hand polydactyly (HP:0001177)	1.84754757
81	Bile duct proliferation (HP:0001408)	1.84025418
82	Abnormal biliary tract physiology (HP:0012439)	1.84025418
83	Stomach cancer (HP:0012126)	1.83131649
84	Pachygyria (HP:0001302)	1.81122115
85	Postaxial hand polydactyly (HP:0001162)	1.81007425
86	Widely spaced teeth (HP:0000687)	1.80168545
87	Male pseudohermaphroditism (HP:0000037)	1.79994205
88	Abnormality of the fovea (HP:0000493)	1.79372725
89	Sloping forehead (HP:0000340)	1.78018908
90	Furrowed tongue (HP:0000221)	1.77443042
91	Meckel diverticulum (HP:0002245)	1.76311159
92	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74159787
93	Retinitis pigmentosa (HP:0000510)	1.73922237
94	Ectopic kidney (HP:0000086)	1.73807668
95	Urinary bladder sphincter dysfunction (HP:0002839)	1.73505001
96	Methylmalonic acidemia (HP:0002912)	1.73109597
97	Abnormality of the labia minora (HP:0012880)	1.72831753
98	Amyotrophic lateral sclerosis (HP:0007354)	1.72263359
99	Action tremor (HP:0002345)	1.72166104
100	Oculomotor apraxia (HP:0000657)	1.71570061

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.41621062
2	MAP4K2	3.18783929
3	ACVR1B	2.76684231
4	BMPR1B	2.74673843
5	CASK	2.72570752
6	ADRBK2	2.54119191
7	WNK3	2.51982760
8	NUAK1	2.39839520
9	PINK1	2.15919632
10	ZAK	2.15876022
11	MAPK13	1.98698488
12	CAMKK2	1.96866601
13	MAP3K4	1.92426160
14	OXSR1	1.81608126
15	GRK1	1.76783738
16	TRIM28	1.70051700
17	INSRR	1.55937300
18	TAOK3	1.54415050
19	CCNB1	1.44755378
20	WNK4	1.40956489
21	BCR	1.40601642
22	EPHA4	1.38809620
23	MKNK2	1.29508650
24	MARK1	1.29306974
25	PLK2	1.28394741
26	PAK3	1.24513160
27	STK39	1.22113805
28	STK38L	1.20456195
29	CDK19	1.15758069
30	DAPK2	1.15330121
31	TXK	1.11822754
32	CAMK1D	1.10878814
33	CSNK1A1L	1.09526205
34	CSNK1G2	1.09359271
35	MAP2K7	1.05025594
36	TAF1	1.04629274
37	NEK2	1.03866148
38	BRSK2	0.99010494
39	ADRBK1	0.97898967
40	PRKCE	0.97396140
41	CSNK1G1	0.97042367
42	CAMK1G	0.96586296
43	CSNK1G3	0.93344326
44	NTRK3	0.93006279
45	ERBB3	0.89839003
46	PTK2B	0.89635770
47	IRAK1	0.86881016
48	TNIK	0.83720071
49	STK3	0.80567172
50	TNK2	0.79789210
51	LATS1	0.78154526
52	EIF2AK3	0.78125060
53	FER	0.75271363
54	OBSCN	0.70386573
55	DYRK2	0.68947074
56	PRKAA2	0.68858034
57	MAP3K7	0.68725635
58	PRKCG	0.68135473
59	VRK1	0.67216893
60	WEE1	0.67035254
61	TGFBR1	0.65861411
62	AKT3	0.65126003
63	CAMK1	0.64831168
64	PIK3CA	0.64393297
65	MKNK1	0.63534170
66	PLK3	0.63270009
67	GRK5	0.59514160
68	CAMK2A	0.56758596
69	PLK4	0.56539574
70	PNCK	0.56258046
71	PKN1	0.55055945
72	CAMK4	0.53203695
73	TEC	0.52895919
74	ATR	0.51825709
75	PHKG2	0.50034326
76	PHKG1	0.50034326
77	PRKAA1	0.46145978
78	ATM	0.45248633
79	DYRK1A	0.44743066
80	STK11	0.44348160
81	FGFR2	0.44103059
82	CHEK2	0.44046245
83	CSNK1A1	0.43435882
84	BCKDK	0.42953778
85	CSNK1D	0.42533207
86	TIE1	0.42425130
87	PLK1	0.41118201
88	SGK2	0.39539498
89	PRKACA	0.39253058
90	PRKCI	0.36796457
91	NTRK2	0.36100328
92	MUSK	0.34860068
93	CHUK	0.34034828
94	NLK	0.32033775
95	PRKG1	0.31607920
96	TLK1	0.31335292
97	PRKCQ	0.31087840
98	ERBB2	0.30753428
99	PIK3CG	0.29870533
100	PRKCZ	0.29196248

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.82991921
2	Phototransduction_Homo sapiens_hsa04744	2.73519739
3	Butanoate metabolism_Homo sapiens_hsa00650	2.51906760
4	Nicotine addiction_Homo sapiens_hsa05033	2.40004855
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.33884819
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.30718874
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.25275086
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.20954370
9	Propanoate metabolism_Homo sapiens_hsa00640	2.20867205
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.16680645
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.12294296
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.03791535
13	Homologous recombination_Homo sapiens_hsa03440	2.03741787
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00293954
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.96009278
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.92963723
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92576016
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.91084106
19	Basal transcription factors_Homo sapiens_hsa03022	1.84674016
20	Taste transduction_Homo sapiens_hsa04742	1.81986126
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.79029874
22	Caffeine metabolism_Homo sapiens_hsa00232	1.69005995
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.68827728
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.66314016
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59980579
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.50370367
27	RNA polymerase_Homo sapiens_hsa03020	1.49473888
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.45642486
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37380742
30	Regulation of autophagy_Homo sapiens_hsa04140	1.36958855
31	Olfactory transduction_Homo sapiens_hsa04740	1.36745232
32	ABC transporters_Homo sapiens_hsa02010	1.35954851
33	Morphine addiction_Homo sapiens_hsa05032	1.31773824
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.29272658
35	Peroxisome_Homo sapiens_hsa04146	1.17962453
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17818418
37	Protein export_Homo sapiens_hsa03060	1.16472994
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.15723872
39	RNA degradation_Homo sapiens_hsa03018	1.13310018
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.07196914
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07049024
42	Circadian entrainment_Homo sapiens_hsa04713	1.05330555
43	GABAergic synapse_Homo sapiens_hsa04727	1.04447489
44	Salivary secretion_Homo sapiens_hsa04970	1.02221905
45	Retinol metabolism_Homo sapiens_hsa00830	0.99943849
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.94619701
47	One carbon pool by folate_Homo sapiens_hsa00670	0.93736498
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.92021928
49	Calcium signaling pathway_Homo sapiens_hsa04020	0.89996245
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89717659
51	Serotonergic synapse_Homo sapiens_hsa04726	0.89664637
52	Lysine degradation_Homo sapiens_hsa00310	0.89230697
53	Insulin secretion_Homo sapiens_hsa04911	0.88246909
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87376314
55	Circadian rhythm_Homo sapiens_hsa04710	0.84906781
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.83566191
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82482964
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79657845
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76560104
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75715467
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75510691
62	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75406841
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75203816
64	Long-term depression_Homo sapiens_hsa04730	0.73690330
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.70786404
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69504971
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68849148
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68070854
69	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.67797709
70	Oxidative phosphorylation_Homo sapiens_hsa00190	0.64559820
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.62097414
72	Fatty acid degradation_Homo sapiens_hsa00071	0.61741008
73	Histidine metabolism_Homo sapiens_hsa00340	0.56273067
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55620649
75	Metabolic pathways_Homo sapiens_hsa01100	0.54712191
76	Purine metabolism_Homo sapiens_hsa00230	0.54616034
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50447188
78	Dopaminergic synapse_Homo sapiens_hsa04728	0.48560466
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47197623
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.44464095
81	Parkinsons disease_Homo sapiens_hsa05012	0.44295183
82	Base excision repair_Homo sapiens_hsa03410	0.43116753
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41536628
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.40623118
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40416243
86	Huntingtons disease_Homo sapiens_hsa05016	0.40075445
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39778484
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.38191886
89	Fatty acid elongation_Homo sapiens_hsa00062	0.36600421
90	Cocaine addiction_Homo sapiens_hsa05030	0.35692700
91	Gastric acid secretion_Homo sapiens_hsa04971	0.35192756
92	Mineral absorption_Homo sapiens_hsa04978	0.34804848
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34307731
94	Cholinergic synapse_Homo sapiens_hsa04725	0.34250352
95	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32207897
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.30899883
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28370514
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28302922
99	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.28288505
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.27715178

ZNF233

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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