ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.18782297
2	fucose catabolic process (GO:0019317)	4.28158726
3	L-fucose metabolic process (GO:0042354)	4.28158726
4	L-fucose catabolic process (GO:0042355)	4.28158726
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.94921125
6	platelet dense granule organization (GO:0060155)	3.80963219
7	neural tube formation (GO:0001841)	3.79833641
8	response to pheromone (GO:0019236)	3.66183456
9	nonmotile primary cilium assembly (GO:0035058)	3.64912806
10	negative regulation of telomere maintenance (GO:0032205)	3.58847066
11	respiratory chain complex IV assembly (GO:0008535)	3.49542335
12	intraciliary transport (GO:0042073)	3.40041044
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.35250206
14	NADH dehydrogenase complex assembly (GO:0010257)	3.35250206
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.35250206
16	replication fork processing (GO:0031297)	3.33520926
17	protein complex biogenesis (GO:0070271)	3.31937165
18	tryptophan catabolic process (GO:0006569)	3.29304768
19	indole-containing compound catabolic process (GO:0042436)	3.29304768
20	indolalkylamine catabolic process (GO:0046218)	3.29304768
21	centriole replication (GO:0007099)	3.28589186
22	indolalkylamine metabolic process (GO:0006586)	3.23389952
23	cellular ketone body metabolic process (GO:0046950)	3.21892380
24	DNA double-strand break processing (GO:0000729)	3.20701413
25	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.17453177
26	regulation of cilium movement (GO:0003352)	3.17112622
27	cilium morphogenesis (GO:0060271)	3.16748045
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16070903
29	protein-cofactor linkage (GO:0018065)	3.14314579
30	kynurenine metabolic process (GO:0070189)	3.13963425
31	recombinational repair (GO:0000725)	3.12014672
32	regulation of telomere maintenance (GO:0032204)	3.10641116
33	double-strand break repair via homologous recombination (GO:0000724)	3.10535709
34	protein K11-linked deubiquitination (GO:0035871)	3.09296592
35	peptidyl-histidine modification (GO:0018202)	3.08001640
36	preassembly of GPI anchor in ER membrane (GO:0016254)	3.03044496
37	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.02695669
38	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.02695669
39	regulation of translation, ncRNA-mediated (GO:0045974)	3.02695669
40	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.02114636
41	cytochrome complex assembly (GO:0017004)	3.01708407
42	epithelial cilium movement (GO:0003351)	2.99559193
43	water-soluble vitamin biosynthetic process (GO:0042364)	2.96997580
44	tryptophan metabolic process (GO:0006568)	2.94721836
45	regulation of hexokinase activity (GO:1903299)	2.94398951
46	regulation of glucokinase activity (GO:0033131)	2.94398951
47	photoreceptor cell maintenance (GO:0045494)	2.94293683
48	ketone body metabolic process (GO:1902224)	2.93117944
49	mannosylation (GO:0097502)	2.91378697
50	protein localization to cilium (GO:0061512)	2.90928804
51	presynaptic membrane assembly (GO:0097105)	2.89353041
52	DNA deamination (GO:0045006)	2.88510983
53	regulation of action potential (GO:0098900)	2.85533614
54	detection of light stimulus involved in visual perception (GO:0050908)	2.84196557
55	detection of light stimulus involved in sensory perception (GO:0050962)	2.84196557
56	ubiquinone metabolic process (GO:0006743)	2.84020679
57	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.80902266
58	regulation of mitotic spindle checkpoint (GO:1903504)	2.80902266
59	head development (GO:0060322)	2.80440582
60	cilium organization (GO:0044782)	2.79205090
61	photoreceptor cell development (GO:0042461)	2.77698501
62	gamma-aminobutyric acid transport (GO:0015812)	2.77633885
63	protein polyglutamylation (GO:0018095)	2.77263998
64	ubiquinone biosynthetic process (GO:0006744)	2.77067103
65	kidney morphogenesis (GO:0060993)	2.76883785
66	cilium assembly (GO:0042384)	2.73941386
67	C4-dicarboxylate transport (GO:0015740)	2.70042201
68	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66728120
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66049462
70	reciprocal DNA recombination (GO:0035825)	2.64182470
71	reciprocal meiotic recombination (GO:0007131)	2.64182470
72	pyrimidine nucleobase catabolic process (GO:0006208)	2.64068025
73	pseudouridine synthesis (GO:0001522)	2.63197141
74	somite development (GO:0061053)	2.62324811
75	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.60704857
76	prenylation (GO:0097354)	2.58782367
77	protein prenylation (GO:0018342)	2.58782367
78	reflex (GO:0060004)	2.56099924
79	axoneme assembly (GO:0035082)	2.54066947
80	spinal cord motor neuron differentiation (GO:0021522)	2.53305159
81	DNA strand renaturation (GO:0000733)	2.52131993
82	presynaptic membrane organization (GO:0097090)	2.52094128
83	histone H2A acetylation (GO:0043968)	2.52046953
84	retinal ganglion cell axon guidance (GO:0031290)	2.51598573
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.51421834
86	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.51027846
87	drug catabolic process (GO:0042737)	2.50683011
88	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.50450174
89	DNA demethylation (GO:0080111)	2.50200378
90	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.49685068
91	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.49685068
92	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.49541512
93	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.49541512
94	eye photoreceptor cell development (GO:0042462)	2.49509400
95	cornea development in camera-type eye (GO:0061303)	2.49200402
96	piRNA metabolic process (GO:0034587)	2.47739643
97	indole-containing compound metabolic process (GO:0042430)	2.47489045
98	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.46213403
99	resolution of meiotic recombination intermediates (GO:0000712)	2.45527341
100	postsynaptic membrane organization (GO:0001941)	2.45117725

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.93082325
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.92696139
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.81808500
4	VDR_22108803_ChIP-Seq_LS180_Human	2.76627359
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70075565
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.67103789
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.61584746
8	FUS_26573619_Chip-Seq_HEK293_Human	2.52581211
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51734265
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43394005
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.42116359
12	EWS_26573619_Chip-Seq_HEK293_Human	2.30968214
13	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.28440131
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26263184
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.20372161
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.16489227
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15517423
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.06593417
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05230995
20	P300_19829295_ChIP-Seq_ESCs_Human	2.04912686
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.04758208
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98770719
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.89156475
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80700720
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.77892090
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76967264
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.75937955
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74990862
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69052184
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.67287272
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59676138
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57825147
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.57813159
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56465877
35	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54987342
36	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53150265
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52261683
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.51475928
39	STAT3_23295773_ChIP-Seq_U87_Human	1.47172116
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.47062505
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47062505
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.45614372
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45471512
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44920793
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42687260
46	* MYC_18940864_ChIP-ChIP_HL60_Human	1.42339435
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40736294
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39074555
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39024498
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.38250214
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37735796
52	AR_25329375_ChIP-Seq_VCAP_Human	1.36125091
53	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34294989
54	TCF4_23295773_ChIP-Seq_U87_Human	1.33181153
55	VDR_23849224_ChIP-Seq_CD4+_Human	1.32677020
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31251566
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30870663
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30398707
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29080392
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28345930
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28345930
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28241458
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27534876
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26548055
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.23315262
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.22678760
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21420255
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21420255
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20877633
70	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.20793625
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19414273
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17060288
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16949382
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15054287
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14336665
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14331704
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13852466
78	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.13811425
79	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10952845
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10586088
81	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09710099
82	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09710099
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08419324
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07944855
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07506742
86	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05582625
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.04213846
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02722974
89	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01959901
90	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.00664486
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00316467
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.99805241
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99797225
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.99236391
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99007986
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98395116
97	* AR_20517297_ChIP-Seq_VCAP_Human	0.96523540
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.95853720
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95850726
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.95427561

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.52150458
2	MP0008877_abnormal_DNA_methylation	3.00425337
3	MP0002102_abnormal_ear_morphology	2.81344308
4	MP0006072_abnormal_retinal_apoptosis	2.46482978
5	MP0003195_calcinosis	2.45046360
6	MP0005551_abnormal_eye_electrophysiolog	2.35740310
7	MP0003880_abnormal_central_pattern	2.24371444
8	MP0002938_white_spotting	2.19321878
9	MP0002837_dystrophic_cardiac_calcinosis	2.15874411
10	MP0003136_yellow_coat_color	2.09918498
11	MP0004147_increased_porphyrin_level	2.07336263
12	MP0005253_abnormal_eye_physiology	2.06764716
13	MP0001984_abnormal_olfaction	1.97462560
14	MP0000372_irregular_coat_pigmentation	1.91717129
15	MP0001529_abnormal_vocalization	1.84770182
16	MP0005645_abnormal_hypothalamus_physiol	1.83271958
17	MP0002638_abnormal_pupillary_reflex	1.82976457
18	MP0001968_abnormal_touch/_nociception	1.80968827
19	MP0002876_abnormal_thyroid_physiology	1.77215477
20	MP0006292_abnormal_olfactory_placode	1.75474346
21	MP0008058_abnormal_DNA_repair	1.73808789
22	MP0005084_abnormal_gallbladder_morpholo	1.67214655
23	MP0003787_abnormal_imprinting	1.67198586
24	MP0004142_abnormal_muscle_tone	1.64956191
25	MP0009046_muscle_twitch	1.64685113
26	MP0004885_abnormal_endolymph	1.62623516
27	MP0004043_abnormal_pH_regulation	1.62364434
28	MP0000427_abnormal_hair_cycle	1.62324185
29	MP0002736_abnormal_nociception_after	1.58550095
30	MP0005174_abnormal_tail_pigmentation	1.56416383
31	MP0002163_abnormal_gland_morphology	1.55447892
32	MP0001986_abnormal_taste_sensitivity	1.54941219
33	MP0003646_muscle_fatigue	1.53397320
34	MP0008995_early_reproductive_senescence	1.52398586
35	MP0003718_maternal_effect	1.49765741
36	MP0004133_heterotaxia	1.47272438
37	MP0006276_abnormal_autonomic_nervous	1.45620069
38	MP0009745_abnormal_behavioral_response	1.44952887
39	MP0008872_abnormal_physiological_respon	1.42974242
40	MP0001486_abnormal_startle_reflex	1.39100910
41	MP0004924_abnormal_behavior	1.37746108
42	MP0005386_behavior/neurological_phenoty	1.37746108
43	MP0005379_endocrine/exocrine_gland_phen	1.36777153
44	MP0003011_delayed_dark_adaptation	1.35018818
45	MP0006054_spinal_hemorrhage	1.34439324
46	MP0002272_abnormal_nervous_system	1.31800708
47	MP0005187_abnormal_penis_morphology	1.30734072
48	MP0000631_abnormal_neuroendocrine_gland	1.30059604
49	MP0002095_abnormal_skin_pigmentation	1.26127938
50	MP0003121_genomic_imprinting	1.24041678
51	MP0004215_abnormal_myocardial_fiber	1.21262126
52	MP0002234_abnormal_pharynx_morphology	1.20427858
53	MP0001485_abnormal_pinna_reflex	1.16338531
54	MP0005646_abnormal_pituitary_gland	1.15830355
55	MP0003122_maternal_imprinting	1.15193259
56	MP0003890_abnormal_embryonic-extraembry	1.14961819
57	MP0008775_abnormal_heart_ventricle	1.14021170
58	MP0004145_abnormal_muscle_electrophysio	1.11963128
59	MP0002751_abnormal_autonomic_nervous	1.11960980
60	MP0003937_abnormal_limbs/digits/tail_de	1.11632095
61	MP0003567_abnormal_fetal_cardiomyocyte	1.11545603
62	MP0008875_abnormal_xenobiotic_pharmacok	1.10242456
63	MP0000647_abnormal_sebaceous_gland	1.09754887
64	MP0008057_abnormal_DNA_replication	1.09463433
65	MP0001501_abnormal_sleep_pattern	1.09146559
66	MP0002557_abnormal_social/conspecific_i	1.07403865
67	MP0005075_abnormal_melanosome_morpholog	1.05866179
68	MP0002572_abnormal_emotion/affect_behav	1.05663197
69	MP0002160_abnormal_reproductive_system	1.05505086
70	MP0000778_abnormal_nervous_system	1.05303283
71	MP0004742_abnormal_vestibular_system	1.04861620
72	MP0005389_reproductive_system_phenotype	1.03813616
73	MP0005195_abnormal_posterior_eye	1.03373066
74	MP0001293_anophthalmia	0.97301018
75	MP0002735_abnormal_chemical_nociception	0.95886511
76	MP0001324_abnormal_eye_pigmentation	0.95844517
77	MP0008789_abnormal_olfactory_epithelium	0.94404912
78	MP0003137_abnormal_impulse_conducting	0.93899264
79	MP0002254_reproductive_system_inflammat	0.93558787
80	MP0001764_abnormal_homeostasis	0.93332675
81	MP0000383_abnormal_hair_follicle	0.93101016
82	MP0002752_abnormal_somatic_nervous	0.90882050
83	MP0002067_abnormal_sensory_capabilities	0.90167216
84	MP0000516_abnormal_urinary_system	0.90080514
85	MP0005367_renal/urinary_system_phenotyp	0.90080514
86	MP0005391_vision/eye_phenotype	0.89699600
87	MP0009697_abnormal_copulation	0.89198593
88	MP0002928_abnormal_bile_duct	0.87440386
89	MP0002277_abnormal_respiratory_mucosa	0.86635944
90	MP0002064_seizures	0.85534983
91	MP0002653_abnormal_ependyma_morphology	0.84622733
92	MP0003786_premature_aging	0.84206865
93	MP0005377_hearing/vestibular/ear_phenot	0.83761803
94	MP0003878_abnormal_ear_physiology	0.83761803
95	MP0002733_abnormal_thermal_nociception	0.80104210
96	MP0001970_abnormal_pain_threshold	0.79608522
97	MP0010094_abnormal_chromosome_stability	0.79310473
98	MP0001919_abnormal_reproductive_system	0.76105491
99	MP0003635_abnormal_synaptic_transmissio	0.74966530
100	MP0001502_abnormal_circadian_rhythm	0.74316447

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.03891467
2	Pancreatic fibrosis (HP:0100732)	3.70740271
3	Abnormality of midbrain morphology (HP:0002418)	3.54818788
4	Molar tooth sign on MRI (HP:0002419)	3.54818788
5	Congenital stationary night blindness (HP:0007642)	3.45922674
6	Nephronophthisis (HP:0000090)	3.39903840
7	True hermaphroditism (HP:0010459)	3.39522536
8	Type II lissencephaly (HP:0007260)	3.32360234
9	Medial flaring of the eyebrow (HP:0010747)	3.23033273
10	Hyperventilation (HP:0002883)	3.21417492
11	Abnormality of the renal medulla (HP:0100957)	3.13207544
12	Abnormality of the renal cortex (HP:0011035)	3.10927049
13	Renal cortical cysts (HP:0000803)	2.84021112
14	Nephrogenic diabetes insipidus (HP:0009806)	2.80662268
15	Lissencephaly (HP:0001339)	2.76764691
16	Gait imbalance (HP:0002141)	2.74605807
17	Congenital primary aphakia (HP:0007707)	2.71107077
18	Colon cancer (HP:0003003)	2.65600972
19	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.65359640
20	Abnormality of alanine metabolism (HP:0010916)	2.65359640
21	Hyperalaninemia (HP:0003348)	2.65359640
22	Inability to walk (HP:0002540)	2.54811597
23	Abolished electroretinogram (ERG) (HP:0000550)	2.54367561
24	Intestinal atresia (HP:0011100)	2.48267828
25	Pendular nystagmus (HP:0012043)	2.47620418
26	Attenuation of retinal blood vessels (HP:0007843)	2.43561880
27	Large for gestational age (HP:0001520)	2.38473398
28	Cerebellar dysplasia (HP:0007033)	2.37967327
29	Chronic hepatic failure (HP:0100626)	2.35003432
30	Abnormality of the labia minora (HP:0012880)	2.31767157
31	Cystic liver disease (HP:0006706)	2.29198072
32	Hemiparesis (HP:0001269)	2.27851290
33	Acute necrotizing encephalopathy (HP:0006965)	2.23731669
34	Increased CSF lactate (HP:0002490)	2.21618651
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.20287695
36	Gaze-evoked nystagmus (HP:0000640)	2.20205705
37	Keratoconus (HP:0000563)	2.19868001
38	Increased corneal curvature (HP:0100692)	2.19868001
39	Genital tract atresia (HP:0001827)	2.19520443
40	Progressive inability to walk (HP:0002505)	2.18198938
41	Vaginal atresia (HP:0000148)	2.17489813
42	Sclerocornea (HP:0000647)	2.15577517
43	Tubular atrophy (HP:0000092)	2.13246564
44	Patellar aplasia (HP:0006443)	2.12357650
45	Decreased central vision (HP:0007663)	2.12162392
46	Acute encephalopathy (HP:0006846)	2.10715969
47	Hypoplasia of the pons (HP:0012110)	2.10195369
48	Mitochondrial inheritance (HP:0001427)	2.09788863
49	Hypothermia (HP:0002045)	2.09360374
50	Abnormality of the pons (HP:0007361)	2.08639097
51	Bile duct proliferation (HP:0001408)	2.08395871
52	Abnormal biliary tract physiology (HP:0012439)	2.08395871
53	Congenital hepatic fibrosis (HP:0002612)	2.08117366
54	Absent speech (HP:0001344)	2.07991467
55	Abnormality of the ileum (HP:0001549)	2.06817547
56	Hepatocellular necrosis (HP:0001404)	2.06480572
57	Methylmalonic acidemia (HP:0002912)	2.06217600
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.04800792
59	Progressive macrocephaly (HP:0004481)	2.03945396
60	Optic nerve hypoplasia (HP:0000609)	1.99961120
61	Poor coordination (HP:0002370)	1.99715326
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99045429
63	Retinal dysplasia (HP:0007973)	1.98687133
64	Aplasia/Hypoplasia of the patella (HP:0006498)	1.97403477
65	Chorioretinal atrophy (HP:0000533)	1.96969129
66	Volvulus (HP:0002580)	1.95484675
67	Hepatic necrosis (HP:0002605)	1.92253692
68	Abnormality of chromosome stability (HP:0003220)	1.91584922
69	Protruding tongue (HP:0010808)	1.91197190
70	Meckel diverticulum (HP:0002245)	1.90460635
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90453469
72	Abnormal mitochondria in muscle tissue (HP:0008316)	1.90371899
73	Tubulointerstitial nephritis (HP:0001970)	1.90291566
74	Hyperglycinemia (HP:0002154)	1.90270924
75	Birth length less than 3rd percentile (HP:0003561)	1.90265193
76	Furrowed tongue (HP:0000221)	1.89472332
77	Optic disc pallor (HP:0000543)	1.89167511
78	Abnormal rod and cone electroretinograms (HP:0008323)	1.89034006
79	Polydipsia (HP:0001959)	1.87363546
80	Abnormal drinking behavior (HP:0030082)	1.87363546
81	Supernumerary spleens (HP:0009799)	1.84420776
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83631067
83	Dandy-Walker malformation (HP:0001305)	1.82707207
84	Anencephaly (HP:0002323)	1.82146536
85	Methylmalonic aciduria (HP:0012120)	1.82116402
86	Postaxial hand polydactyly (HP:0001162)	1.81342209
87	Postaxial foot polydactyly (HP:0001830)	1.81034877
88	Congenital, generalized hypertrichosis (HP:0004540)	1.80175574
89	Progressive cerebellar ataxia (HP:0002073)	1.79275759
90	Broad-based gait (HP:0002136)	1.78686330
91	Ketoacidosis (HP:0001993)	1.76587617
92	Fair hair (HP:0002286)	1.74197505
93	Astigmatism (HP:0000483)	1.72914126
94	Hip dysplasia (HP:0001385)	1.71095236
95	Severe muscular hypotonia (HP:0006829)	1.71087234
96	Male pseudohermaphroditism (HP:0000037)	1.68810639
97	Pachygyria (HP:0001302)	1.68801384
98	Stomach cancer (HP:0012126)	1.66366323
99	Tachypnea (HP:0002789)	1.66208733
100	Sloping forehead (HP:0000340)	1.66164506

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.33500223
2	TRIM28	3.17928565
3	BMPR1B	3.07238754
4	WNK3	2.99055347
5	NUAK1	2.81957606
6	ADRBK2	2.63084384
7	MAP4K2	2.60955657
8	INSRR	2.47463760
9	CASK	2.36821710
10	ZAK	2.29328094
11	BCR	2.19570888
12	GRK1	2.10758201
13	ACVR1B	2.10666322
14	PNCK	1.99182610
15	MAP3K4	1.87701060
16	MAPK13	1.87253442
17	TNIK	1.73649312
18	WNK4	1.72040202
19	PINK1	1.54543153
20	MKNK2	1.38451545
21	BCKDK	1.37392464
22	TLK1	1.35821202
23	WEE1	1.23009951
24	OXSR1	1.19268279
25	DYRK2	1.16076697
26	ERBB3	1.13956332
27	CAMKK2	1.13279492
28	TGFBR1	1.09411909
29	MARK1	1.08083185
30	PAK3	1.07239187
31	VRK1	1.06974962
32	STK39	1.06794423
33	TAOK3	1.05525956
34	DAPK2	1.03644970
35	CSNK1G1	1.02681531
36	VRK2	1.02471095
37	STK38L	1.01909867
38	MAP2K7	1.00110848
39	ADRBK1	0.97412263
40	PLK2	0.97235874
41	CSNK1G3	0.96752505
42	CSNK1G2	0.96178719
43	PRKCE	0.96162330
44	MKNK1	0.95849365
45	STK3	0.95301811
46	PLK3	0.94603444
47	TIE1	0.92469985
48	BRSK2	0.91645566
49	BUB1	0.91375606
50	CSNK1A1L	0.88993098
51	TAF1	0.87870541
52	TXK	0.87024192
53	PLK4	0.86008328
54	CAMK1G	0.74881909
55	PRKCG	0.73570071
56	SRPK1	0.69368262
57	TSSK6	0.65939774
58	FGFR2	0.65636486
59	EPHA4	0.63886991
60	TEC	0.63088705
61	DYRK1A	0.62526975
62	EIF2AK3	0.60655426
63	PIK3CA	0.60011631
64	NLK	0.59721135
65	PLK1	0.58150234
66	CAMK1D	0.55501293
67	OBSCN	0.54688682
68	ATR	0.52782847
69	PTK2B	0.50552764
70	RPS6KA5	0.48721226
71	PKN1	0.47773428
72	ATM	0.46394660
73	PHKG1	0.46129940
74	PHKG2	0.46129940
75	CSNK1A1	0.44357563
76	CAMK1	0.44240626
77	CAMK2A	0.43843685
78	CHUK	0.41107493
79	CHEK2	0.40062803
80	EIF2AK2	0.39888654
81	CSNK1D	0.39887842
82	MAPK15	0.39012495
83	NTRK2	0.37134297
84	PRKACA	0.37081744
85	FLT3	0.36504123
86	KIT	0.36401537
87	MUSK	0.35988474
88	PRKCQ	0.35785988
89	CCNB1	0.33126151
90	GRK5	0.31377320
91	CDK3	0.31282042
92	NME1	0.31196427
93	NEK2	0.31140663
94	STK11	0.30821979
95	MST4	0.30215606
96	PRKACB	0.28790146
97	IKBKB	0.28401987
98	PRKG1	0.27773344
99	MAPKAPK5	0.27667915
100	IRAK1	0.26585520

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.88759560
2	Butanoate metabolism_Homo sapiens_hsa00650	2.66733946
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.63090682
4	Homologous recombination_Homo sapiens_hsa03440	2.61336818
5	Protein export_Homo sapiens_hsa03060	2.45590866
6	Phototransduction_Homo sapiens_hsa04744	2.32363312
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.11747117
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.08085490
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.04785475
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02589166
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.02383973
12	Propanoate metabolism_Homo sapiens_hsa00640	2.01981127
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.01651614
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.01421140
15	Oxidative phosphorylation_Homo sapiens_hsa00190	2.01252275
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.94487600
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.94414146
18	Basal transcription factors_Homo sapiens_hsa03022	1.89296659
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.82976318
20	RNA polymerase_Homo sapiens_hsa03020	1.80899283
21	Nicotine addiction_Homo sapiens_hsa05033	1.80803623
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.79076223
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.72033603
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.67216514
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.61803742
26	RNA degradation_Homo sapiens_hsa03018	1.54583975
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.52170627
28	One carbon pool by folate_Homo sapiens_hsa00670	1.50097209
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.47239022
30	Parkinsons disease_Homo sapiens_hsa05012	1.47050929
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.45812769
32	Peroxisome_Homo sapiens_hsa04146	1.42969777
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.34623429
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.28174963
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27688875
36	Taste transduction_Homo sapiens_hsa04742	1.19765923
37	Caffeine metabolism_Homo sapiens_hsa00232	1.18794694
38	Olfactory transduction_Homo sapiens_hsa04740	1.16430160
39	Huntingtons disease_Homo sapiens_hsa05016	1.07480319
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06869512
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06110070
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04550959
43	ABC transporters_Homo sapiens_hsa02010	1.02991061
44	Morphine addiction_Homo sapiens_hsa05032	0.99140084
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.95859913
46	Regulation of autophagy_Homo sapiens_hsa04140	0.93370982
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.91285796
48	GABAergic synapse_Homo sapiens_hsa04727	0.88667580
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.88570343
50	Retinol metabolism_Homo sapiens_hsa00830	0.87110150
51	Alzheimers disease_Homo sapiens_hsa05010	0.86244846
52	Circadian rhythm_Homo sapiens_hsa04710	0.85033945
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84354216
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84350511
55	Purine metabolism_Homo sapiens_hsa00230	0.83632264
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82924491
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79953063
58	Mismatch repair_Homo sapiens_hsa03430	0.77962637
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75412791
60	RNA transport_Homo sapiens_hsa03013	0.74956868
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74450485
62	Circadian entrainment_Homo sapiens_hsa04713	0.74397893
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.74221283
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74120038
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73728039
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72801711
67	Proteasome_Homo sapiens_hsa03050	0.68830875
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68730557
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67769133
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67247798
71	Serotonergic synapse_Homo sapiens_hsa04726	0.66484839
72	Metabolic pathways_Homo sapiens_hsa01100	0.65947757
73	Asthma_Homo sapiens_hsa05310	0.64782918
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61946432
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.60999111
76	Insulin secretion_Homo sapiens_hsa04911	0.60722255
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60164852
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.57406848
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55414572
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.54875119
81	Fatty acid elongation_Homo sapiens_hsa00062	0.54167086
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54049836
83	p53 signaling pathway_Homo sapiens_hsa04115	0.50987778
84	Histidine metabolism_Homo sapiens_hsa00340	0.48657422
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48556913
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48492638
87	Type I diabetes mellitus_Homo sapiens_hsa04940	0.45938769
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44882667
89	Fatty acid degradation_Homo sapiens_hsa00071	0.44607443
90	Base excision repair_Homo sapiens_hsa03410	0.43159409
91	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38292973
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38095232
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.37806537
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37761627
95	Spliceosome_Homo sapiens_hsa03040	0.36312884
96	Salivary secretion_Homo sapiens_hsa04970	0.35054881
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.34384199
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.33930100
99	Lysine degradation_Homo sapiens_hsa00310	0.31345757
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.31141486

ZNF234

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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