ZNF235

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mouse Zfp93 protein. This gene is located in a cluster of zinc finger genes on 19q13.2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.58557151
2regulation of meiosis I (GO:0060631)4.59040477
3behavioral response to nicotine (GO:0035095)4.24927961
4DNA double-strand break processing (GO:0000729)4.24661906
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95037104
6DNA methylation involved in gamete generation (GO:0043046)3.84516109
7epithelial cilium movement (GO:0003351)3.84079485
8protein K11-linked deubiquitination (GO:0035871)3.58549198
9cellular ketone body metabolic process (GO:0046950)3.56711792
10neural tube formation (GO:0001841)3.53698441
11platelet dense granule organization (GO:0060155)3.53041254
12resolution of meiotic recombination intermediates (GO:0000712)3.41432160
13synapsis (GO:0007129)3.41269427
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.37557243
15tachykinin receptor signaling pathway (GO:0007217)3.35580168
16intraciliary transport (GO:0042073)3.35346564
17single strand break repair (GO:0000012)3.25426688
18cilium movement (GO:0003341)3.24235396
19replication fork processing (GO:0031297)3.21518520
20somite rostral/caudal axis specification (GO:0032525)3.21066891
21peptidyl-histidine modification (GO:0018202)3.18001492
22ketone body metabolic process (GO:1902224)3.15394964
23preassembly of GPI anchor in ER membrane (GO:0016254)3.15128141
24cilium or flagellum-dependent cell motility (GO:0001539)3.12246479
25respiratory chain complex IV assembly (GO:0008535)3.11311759
26male meiosis I (GO:0007141)3.09600839
27presynaptic membrane assembly (GO:0097105)3.03568288
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.03176486
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03176486
30histone H2A acetylation (GO:0043968)3.02718304
31meiotic chromosome segregation (GO:0045132)3.00263397
32prenylation (GO:0097354)2.99817763
33protein prenylation (GO:0018342)2.99817763
34cilium morphogenesis (GO:0060271)2.98918520
35recombinational repair (GO:0000725)2.98338213
36reciprocal DNA recombination (GO:0035825)2.98025860
37reciprocal meiotic recombination (GO:0007131)2.98025860
38cytochrome complex assembly (GO:0017004)2.97964140
39double-strand break repair via homologous recombination (GO:0000724)2.96215166
40male meiosis (GO:0007140)2.95991706
41regulation of action potential (GO:0098900)2.95986019
42establishment of protein localization to Golgi (GO:0072600)2.95252525
43retinal cone cell development (GO:0046549)2.93532362
44response to pheromone (GO:0019236)2.93214812
45organelle disassembly (GO:1903008)2.89084192
46protein complex biogenesis (GO:0070271)2.88484883
47nonmotile primary cilium assembly (GO:0035058)2.86260552
48axoneme assembly (GO:0035082)2.85005580
49DNA deamination (GO:0045006)2.84666154
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83974476
51meiotic cell cycle (GO:0051321)2.82231636
52photoreceptor cell maintenance (GO:0045494)2.81436912
53mitochondrial respiratory chain complex assembly (GO:0033108)2.80668914
54water-soluble vitamin biosynthetic process (GO:0042364)2.79313196
55cilium organization (GO:0044782)2.77434225
56postreplication repair (GO:0006301)2.77052052
57protein K6-linked ubiquitination (GO:0085020)2.76126655
58somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76064612
59isotype switching (GO:0045190)2.76064612
60somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76064612
61protein polyglutamylation (GO:0018095)2.74850238
62microtubule anchoring (GO:0034453)2.74197004
63detection of light stimulus involved in visual perception (GO:0050908)2.73760137
64detection of light stimulus involved in sensory perception (GO:0050962)2.73760137
65cilium assembly (GO:0042384)2.72732821
66cullin deneddylation (GO:0010388)2.72574642
67proteasome assembly (GO:0043248)2.72477860
68mechanosensory behavior (GO:0007638)2.70935969
69somite development (GO:0061053)2.68952493
70L-fucose catabolic process (GO:0042355)2.68198712
71fucose catabolic process (GO:0019317)2.68198712
72L-fucose metabolic process (GO:0042354)2.68198712
73C4-dicarboxylate transport (GO:0015740)2.65760082
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65156423
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.65156423
76NADH dehydrogenase complex assembly (GO:0010257)2.65156423
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65155971
78regulation of cilium movement (GO:0003352)2.64963827
79protein targeting to Golgi (GO:0000042)2.62847953
80regulation of glucokinase activity (GO:0033131)2.60734445
81regulation of hexokinase activity (GO:1903299)2.60734445
82negative regulation of mast cell activation (GO:0033004)2.59556830
83pseudouridine synthesis (GO:0001522)2.59156740
84chromatin remodeling at centromere (GO:0031055)2.59090704
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58986754
86positive regulation of action potential (GO:0045760)2.58669798
87anterograde synaptic vesicle transport (GO:0048490)2.57695238
88lactate metabolic process (GO:0006089)2.57482916
89regulation of sarcomere organization (GO:0060297)2.57170877
90negative regulation of DNA recombination (GO:0045910)2.56988032
91attachment of spindle microtubules to kinetochore (GO:0008608)2.55796445
92DNA catabolic process, exonucleolytic (GO:0000738)2.55754910
93indolalkylamine metabolic process (GO:0006586)2.53526298
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53194311
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53136189
96regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51445958
97regulation of mitotic spindle checkpoint (GO:1903504)2.51445958
98protein localization to cilium (GO:0061512)2.51444402
99meiosis I (GO:0007127)2.51170449
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.50244562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.82462168
2VDR_22108803_ChIP-Seq_LS180_Human3.21724134
3IGF1R_20145208_ChIP-Seq_DFB_Human2.84714016
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.70669007
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69345504
6GBX2_23144817_ChIP-Seq_PC3_Human2.65479230
7FUS_26573619_Chip-Seq_HEK293_Human2.53601551
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.52318492
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45596803
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43886774
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.38122363
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.37731660
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37357470
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.36433692
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35902080
16EWS_26573619_Chip-Seq_HEK293_Human2.34972129
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27304817
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19611902
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18271156
20TAF15_26573619_Chip-Seq_HEK293_Human2.08637261
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03885202
22EZH2_22144423_ChIP-Seq_EOC_Human1.99924892
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94257107
24ELK1_19687146_ChIP-ChIP_HELA_Human1.93533392
25P300_19829295_ChIP-Seq_ESCs_Human1.91237064
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83391819
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81799789
28VDR_23849224_ChIP-Seq_CD4+_Human1.80351875
29IRF1_19129219_ChIP-ChIP_H3396_Human1.71519495
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68584573
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66979539
32ER_23166858_ChIP-Seq_MCF-7_Human1.63975993
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63681168
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63219642
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60459182
36CBP_20019798_ChIP-Seq_JUKART_Human1.60459182
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60408247
38* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59626387
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57007942
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52108218
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48658279
42STAT3_23295773_ChIP-Seq_U87_Human1.43607825
43SMAD4_21799915_ChIP-Seq_A2780_Human1.43371809
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42645974
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.42022213
46MYC_18940864_ChIP-ChIP_HL60_Human1.38606683
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37830909
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36066557
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34608375
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33747695
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32346453
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29779439
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29609691
54BCAT_22108803_ChIP-Seq_LS180_Human1.29512096
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29160567
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.29067479
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28226933
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27691689
59TCF4_23295773_ChIP-Seq_U87_Human1.26206923
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.26189205
61FOXP3_21729870_ChIP-Seq_TREG_Human1.25591364
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.25484325
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25090191
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24754149
65* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24446349
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24102201
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24061337
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23565867
69* ETS1_20019798_ChIP-Seq_JURKAT_Human1.22279003
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19786636
71SOX2_19829295_ChIP-Seq_ESCs_Human1.19546179
72NANOG_19829295_ChIP-Seq_ESCs_Human1.19546179
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19355372
74TP53_22573176_ChIP-Seq_HFKS_Human1.19048165
75RUNX2_22187159_ChIP-Seq_PCA_Human1.13512462
76AR_25329375_ChIP-Seq_VCAP_Human1.12345465
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12024224
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11926879
79TCF4_22108803_ChIP-Seq_LS180_Human1.11444555
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10904995
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10904995
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09926138
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09742435
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.09140154
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08558847
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.06448084
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04951630
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.04310744
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03004478
90RNF2_27304074_Chip-Seq_NSC_Mouse1.02864540
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01989801
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00448492
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99583757
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.99008960
95SRF_21415370_ChIP-Seq_HL-1_Mouse0.98986866
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97848709
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.97848709
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97723608
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.95016569
100P53_22387025_ChIP-Seq_ESCs_Mouse0.94239026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.95278663
2MP0000569_abnormal_digit_pigmentation3.37019826
3MP0008058_abnormal_DNA_repair3.20764412
4MP0002102_abnormal_ear_morphology2.80791059
5MP0006072_abnormal_retinal_apoptosis2.41110553
6MP0008057_abnormal_DNA_replication2.37397336
7MP0003195_calcinosis2.31051819
8MP0002638_abnormal_pupillary_reflex2.15734225
9MP0003880_abnormal_central_pattern2.11031819
10MP0003787_abnormal_imprinting2.07093064
11MP0005253_abnormal_eye_physiology2.04347782
12MP0006276_abnormal_autonomic_nervous2.04087607
13MP0005551_abnormal_eye_electrophysiolog2.03193976
14MP0010094_abnormal_chromosome_stability1.96688354
15MP0002837_dystrophic_cardiac_calcinosis1.92995817
16MP0006292_abnormal_olfactory_placode1.85457776
17MP0005645_abnormal_hypothalamus_physiol1.84151952
18MP0002138_abnormal_hepatobiliary_system1.83843634
19MP0003136_yellow_coat_color1.83150993
20MP0003121_genomic_imprinting1.81228194
21MP0003890_abnormal_embryonic-extraembry1.79688999
22MP0005084_abnormal_gallbladder_morpholo1.79649350
23MP0004133_heterotaxia1.79017426
24MP0005174_abnormal_tail_pigmentation1.76363373
25MP0002928_abnormal_bile_duct1.73422849
26MP0008995_early_reproductive_senescence1.72346008
27MP0003567_abnormal_fetal_cardiomyocyte1.70169492
28MP0010386_abnormal_urinary_bladder1.68611910
29MP0002938_white_spotting1.66998818
30MP0000372_irregular_coat_pigmentation1.66856094
31MP0004142_abnormal_muscle_tone1.63677109
32MP0005075_abnormal_melanosome_morpholog1.62486837
33MP0003718_maternal_effect1.54710067
34MP0002653_abnormal_ependyma_morphology1.53435418
35MP0001293_anophthalmia1.50519298
36MP0004043_abnormal_pH_regulation1.50253505
37MP0003122_maternal_imprinting1.43236605
38MP0000427_abnormal_hair_cycle1.42884687
39MP0004215_abnormal_myocardial_fiber1.38756455
40MP0000631_abnormal_neuroendocrine_gland1.38166284
41MP0003786_premature_aging1.36362942
42MP0003011_delayed_dark_adaptation1.34311729
43MP0002210_abnormal_sex_determination1.28333096
44MP0002751_abnormal_autonomic_nervous1.26183899
45MP0001984_abnormal_olfaction1.26013188
46MP0001929_abnormal_gametogenesis1.25045677
47MP0001968_abnormal_touch/_nociception1.25041620
48MP0001986_abnormal_taste_sensitivity1.24271058
49MP0005646_abnormal_pituitary_gland1.24009380
50MP0001764_abnormal_homeostasis1.23123341
51MP0001324_abnormal_eye_pigmentation1.18971882
52MP0000015_abnormal_ear_pigmentation1.18891964
53MP0001529_abnormal_vocalization1.18487419
54MP0009046_muscle_twitch1.17447211
55MP0001486_abnormal_startle_reflex1.14782098
56MP0004145_abnormal_muscle_electrophysio1.14381938
57MP0009697_abnormal_copulation1.14312798
58MP0002272_abnormal_nervous_system1.13853652
59MP0005171_absent_coat_pigmentation1.13471318
60MP0000778_abnormal_nervous_system1.12577382
61MP0000653_abnormal_sex_gland1.10463495
62MP0009745_abnormal_behavioral_response1.08350779
63MP0000383_abnormal_hair_follicle1.07309580
64MP0002095_abnormal_skin_pigmentation1.06441996
65MP0003698_abnormal_male_reproductive1.05307883
66MP0001188_hyperpigmentation1.04035736
67MP0003646_muscle_fatigue1.03555462
68MP0005167_abnormal_blood-brain_barrier1.03378885
69MP0002736_abnormal_nociception_after1.03000903
70MP0000647_abnormal_sebaceous_gland1.02856393
71MP0005391_vision/eye_phenotype1.00958825
72MP0008961_abnormal_basal_metabolism0.99824128
73MP0001145_abnormal_male_reproductive0.99775067
74MP0005195_abnormal_posterior_eye0.98650992
75MP0008789_abnormal_olfactory_epithelium0.93800411
76MP0002067_abnormal_sensory_capabilities0.92559454
77MP0002163_abnormal_gland_morphology0.91944400
78MP0003119_abnormal_digestive_system0.90087830
79MP0001485_abnormal_pinna_reflex0.89876569
80MP0003937_abnormal_limbs/digits/tail_de0.85596184
81MP0008007_abnormal_cellular_replicative0.84862048
82MP0002160_abnormal_reproductive_system0.83193548
83MP0002752_abnormal_somatic_nervous0.80564506
84MP0004742_abnormal_vestibular_system0.80484844
85MP0004885_abnormal_endolymph0.79201385
86MP0001119_abnormal_female_reproductive0.78605499
87MP0005394_taste/olfaction_phenotype0.78602954
88MP0005499_abnormal_olfactory_system0.78602954
89MP0002064_seizures0.76556644
90MP0006035_abnormal_mitochondrial_morpho0.76462984
91MP0003183_abnormal_peptide_metabolism0.74488135
92MP0003693_abnormal_embryo_hatching0.74352832
93MP0005389_reproductive_system_phenotype0.73217546
94MP0003077_abnormal_cell_cycle0.71072151
95MP0003950_abnormal_plasma_membrane0.70936164
96MP0002233_abnormal_nose_morphology0.69620228
97MP0002090_abnormal_vision0.68937166
98MP0002229_neurodegeneration0.67293877
99MP0006036_abnormal_mitochondrial_physio0.67225773
100MP0001970_abnormal_pain_threshold0.66534493

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)3.85203683
2Abnormality of midbrain morphology (HP:0002418)3.85203683
3Pancreatic cysts (HP:0001737)3.74759440
4Pancreatic fibrosis (HP:0100732)3.48540346
5Medial flaring of the eyebrow (HP:0010747)3.39937932
6True hermaphroditism (HP:0010459)3.32478141
7Nephronophthisis (HP:0000090)2.95750905
8Congenital primary aphakia (HP:0007707)2.93634352
9Gait imbalance (HP:0002141)2.93348210
10Aplasia/Hypoplasia of the tibia (HP:0005772)2.85120805
11Bile duct proliferation (HP:0001408)2.66511122
12Abnormal biliary tract physiology (HP:0012439)2.66511122
13Type II lissencephaly (HP:0007260)2.65261195
14Colon cancer (HP:0003003)2.65242780
15Abnormality of the labia minora (HP:0012880)2.62619658
16Abnormality of the renal medulla (HP:0100957)2.58555738
17Nephrogenic diabetes insipidus (HP:0009806)2.53795263
18Chronic hepatic failure (HP:0100626)2.53773366
19Genital tract atresia (HP:0001827)2.46791187
20Abolished electroretinogram (ERG) (HP:0000550)2.46538156
21Supernumerary spleens (HP:0009799)2.43711182
22Vaginal atresia (HP:0000148)2.41557722
23Abnormality of macular pigmentation (HP:0008002)2.39581594
24Pendular nystagmus (HP:0012043)2.37353878
25Congenital stationary night blindness (HP:0007642)2.35954667
26Short tibia (HP:0005736)2.35036027
27Attenuation of retinal blood vessels (HP:0007843)2.30832528
28Cerebellar dysplasia (HP:0007033)2.29722809
29Methylmalonic acidemia (HP:0002912)2.29371450
30Abnormality of vitamin B metabolism (HP:0004340)2.26117466
31Abnormality of the renal cortex (HP:0011035)2.25840639
32Abnormality of chromosome stability (HP:0003220)2.23606913
333-Methylglutaconic aciduria (HP:0003535)2.21188997
34Fair hair (HP:0002286)2.21104355
35Poor coordination (HP:0002370)2.19393261
36Abnormality of the vitamin B12 metabolism (HP:0004341)2.19149906
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.18364826
38Abnormality of the pons (HP:0007361)2.17104681
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.17027362
40Central scotoma (HP:0000603)2.10070396
41Cystic liver disease (HP:0006706)2.07384486
42Occipital encephalocele (HP:0002085)2.07040613
43Chromsome breakage (HP:0040012)2.06256054
44Anencephaly (HP:0002323)2.05297359
45Rhabdomyosarcoma (HP:0002859)2.03538118
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02134121
47Increased CSF lactate (HP:0002490)2.00703340
48Hypoplasia of the pons (HP:0012110)1.99718031
49Acute necrotizing encephalopathy (HP:0006965)1.98705709
50Postaxial hand polydactyly (HP:0001162)1.97291896
51Decreased central vision (HP:0007663)1.95821847
52Homocystinuria (HP:0002156)1.94805299
53Abnormality of homocysteine metabolism (HP:0010919)1.94805299
54Progressive macrocephaly (HP:0004481)1.93743085
55Meckel diverticulum (HP:0002245)1.89630353
56Clubbing of toes (HP:0100760)1.89427557
57Postaxial foot polydactyly (HP:0001830)1.88879668
58Oculomotor apraxia (HP:0000657)1.86201059
59Oligodactyly (hands) (HP:0001180)1.85967532
60Narrow forehead (HP:0000341)1.83275356
61Abnormality of the metopic suture (HP:0005556)1.82543898
62Hip dysplasia (HP:0001385)1.82350637
63Bony spicule pigmentary retinopathy (HP:0007737)1.80938166
64Abnormality of the ileum (HP:0001549)1.80603874
65Preaxial hand polydactyly (HP:0001177)1.80464826
66Sclerocornea (HP:0000647)1.79857147
67Sloping forehead (HP:0000340)1.79348453
68Astigmatism (HP:0000483)1.79164972
69Abnormal respiratory motile cilium physiology (HP:0012261)1.78968566
70Male pseudohermaphroditism (HP:0000037)1.77940384
71Ectopic kidney (HP:0000086)1.77030688
72Prominent nasal bridge (HP:0000426)1.76651555
73Mitochondrial inheritance (HP:0001427)1.76650868
74Intestinal atresia (HP:0011100)1.76564927
75Scotoma (HP:0000575)1.75844563
76Methylmalonic aciduria (HP:0012120)1.75092084
77Abnormal ciliary motility (HP:0012262)1.74276730
78Broad-based gait (HP:0002136)1.73961678
79Acute encephalopathy (HP:0006846)1.72083367
80Congenital hepatic fibrosis (HP:0002612)1.71925732
81Abnormal respiratory epithelium morphology (HP:0012253)1.71306359
82Abnormal respiratory motile cilium morphology (HP:0005938)1.71306359
83Protruding tongue (HP:0010808)1.71126454
84Abnormality of the fovea (HP:0000493)1.71045647
85Glioma (HP:0009733)1.70988514
86Hyperventilation (HP:0002883)1.70978547
87Volvulus (HP:0002580)1.70761786
88Dandy-Walker malformation (HP:0001305)1.70497979
89Hyperglycinemia (HP:0002154)1.70337139
90Furrowed tongue (HP:0000221)1.70125470
91Facial hemangioma (HP:0000329)1.67755569
92Abnormal protein glycosylation (HP:0012346)1.67740184
93Abnormal glycosylation (HP:0012345)1.67740184
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67740184
95Abnormal protein N-linked glycosylation (HP:0012347)1.67740184
96Gaze-evoked nystagmus (HP:0000640)1.67421136
97Prominent metopic ridge (HP:0005487)1.67390290
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.66390020
99Absent/shortened dynein arms (HP:0200106)1.66390020
100Abnormal rod and cone electroretinograms (HP:0008323)1.66378525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.14621905
2WNK32.97868840
3ACVR1B2.80404636
4NUAK12.61501031
5TSSK62.54970321
6MAP3K42.21875186
7ZAK2.17331713
8TNIK2.08681980
9BMPR1B2.07322283
10MKNK21.82065444
11SRPK11.80593318
12MAP4K21.78423418
13ADRBK21.76714800
14MAPK131.76713623
15PINK11.70771003
16MST41.67957981
17TAOK31.62329924
18STK38L1.48606321
19MKNK11.39715415
20BRSK21.38574979
21LATS11.36438305
22GRK11.34461440
23CASK1.33977636
24PDK21.30236295
25BUB11.24837441
26PLK31.24100516
27VRK11.21309367
28CAMKK21.18289375
29OXSR11.17685601
30PAK31.15163956
31TRIM281.15156174
32EIF2AK31.12673101
33INSRR1.12389874
34MAP2K71.11474956
35PBK1.10032599
36PLK41.06557444
37CSNK1G21.06074977
38DYRK21.03031429
39WNK41.00974421
40DYRK30.97000685
41ERBB30.96446897
42PLK20.95150230
43PNCK0.94960976
44IRAK10.91938891
45MARK10.91308467
46AKT30.91243086
47CSNK1G10.88088473
48FGFR20.86155316
49STK390.86073542
50NLK0.85500522
51BCKDK0.83960958
52TIE10.83770597
53STK30.82536773
54PLK10.82357022
55CSNK1G30.79137324
56ATR0.77878184
57OBSCN0.75397776
58CDC70.74446162
59WEE10.71895736
60CSNK1A1L0.71107226
61TGFBR10.70176663
62STK240.70032310
63EPHA40.69608729
64TLK10.69360147
65PASK0.66607358
66ATM0.66187966
67NTRK30.65380486
68TXK0.64812097
69MAPK150.63740763
70EIF2AK10.63676534
71DAPK20.62800851
72MUSK0.62792482
73RPS6KA50.62209974
74PKN10.61929037
75PRKCE0.61184627
76NTRK20.58611446
77MARK30.58327545
78TEC0.56801806
79CDK30.56325668
80BRD40.53620651
81DYRK1A0.52562128
82CHEK20.52431229
83PRKCG0.50271345
84STK110.46974986
85PTK2B0.46573967
86PIK3CA0.46055004
87CDK190.45849701
88TAF10.45311916
89STK40.44331185
90BCR0.40979941
91SGK20.39974973
92RPS6KA40.39892948
93PIK3CG0.38841719
94CCNB10.38501367
95CHEK10.37871458
96TTK0.37669149
97CAMK40.37451275
98CAMK2A0.36154130
99PRKACA0.35676115
100PRKACB0.34355005

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.14029532
2Protein export_Homo sapiens_hsa030602.97248046
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.90117157
4Fanconi anemia pathway_Homo sapiens_hsa034602.86012359
5Butanoate metabolism_Homo sapiens_hsa006502.81361523
6Non-homologous end-joining_Homo sapiens_hsa034502.68519608
7Basal transcription factors_Homo sapiens_hsa030222.52174539
8Propanoate metabolism_Homo sapiens_hsa006402.36225557
9Homologous recombination_Homo sapiens_hsa034402.27651063
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25600294
11Selenocompound metabolism_Homo sapiens_hsa004502.24915944
12RNA polymerase_Homo sapiens_hsa030202.13677410
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10476089
14Proteasome_Homo sapiens_hsa030502.03272204
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01435450
16Phototransduction_Homo sapiens_hsa047441.98398255
17Oxidative phosphorylation_Homo sapiens_hsa001901.93925786
18RNA degradation_Homo sapiens_hsa030181.93759331
19Fatty acid elongation_Homo sapiens_hsa000621.78018192
20Nicotine addiction_Homo sapiens_hsa050331.67100503
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.64802438
22Nitrogen metabolism_Homo sapiens_hsa009101.60622933
23Mismatch repair_Homo sapiens_hsa034301.59978855
24Parkinsons disease_Homo sapiens_hsa050121.54816554
25Tryptophan metabolism_Homo sapiens_hsa003801.47625279
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41223945
27RNA transport_Homo sapiens_hsa030131.37210622
28Regulation of autophagy_Homo sapiens_hsa041401.35155137
29Huntingtons disease_Homo sapiens_hsa050161.30639474
30Nucleotide excision repair_Homo sapiens_hsa034201.27850598
31Ether lipid metabolism_Homo sapiens_hsa005651.26656401
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26001566
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25729421
34Linoleic acid metabolism_Homo sapiens_hsa005911.25609659
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20436916
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18611405
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.17843723
38Dorso-ventral axis formation_Homo sapiens_hsa043201.16515351
39One carbon pool by folate_Homo sapiens_hsa006701.14852725
40Taste transduction_Homo sapiens_hsa047421.14738111
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11398553
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10137136
43Olfactory transduction_Homo sapiens_hsa047401.10018294
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06505239
45Peroxisome_Homo sapiens_hsa041461.06175681
46Base excision repair_Homo sapiens_hsa034100.97066156
47Collecting duct acid secretion_Homo sapiens_hsa049660.96492895
48ABC transporters_Homo sapiens_hsa020100.96181137
49beta-Alanine metabolism_Homo sapiens_hsa004100.91422882
50mRNA surveillance pathway_Homo sapiens_hsa030150.90911132
51Spliceosome_Homo sapiens_hsa030400.89692317
52Caffeine metabolism_Homo sapiens_hsa002320.89288714
53Purine metabolism_Homo sapiens_hsa002300.88628633
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82580807
55Alzheimers disease_Homo sapiens_hsa050100.78636823
56Steroid biosynthesis_Homo sapiens_hsa001000.75967619
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75869294
58Lysine degradation_Homo sapiens_hsa003100.75614060
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75000553
60Pyrimidine metabolism_Homo sapiens_hsa002400.74440355
61Circadian rhythm_Homo sapiens_hsa047100.72377994
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.70934170
63Systemic lupus erythematosus_Homo sapiens_hsa053220.69444132
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69383704
65Fatty acid degradation_Homo sapiens_hsa000710.69134236
66Oocyte meiosis_Homo sapiens_hsa041140.65784193
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64236515
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.63907974
69Fatty acid metabolism_Homo sapiens_hsa012120.61619753
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59089481
71Cell cycle_Homo sapiens_hsa041100.56802476
72p53 signaling pathway_Homo sapiens_hsa041150.54834564
73Metabolic pathways_Homo sapiens_hsa011000.54570572
74Alcoholism_Homo sapiens_hsa050340.52958828
75Cardiac muscle contraction_Homo sapiens_hsa042600.51546773
76Chemical carcinogenesis_Homo sapiens_hsa052040.49194108
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48056757
78Glycerolipid metabolism_Homo sapiens_hsa005610.46342345
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44665662
80Pyruvate metabolism_Homo sapiens_hsa006200.44395602
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44027032
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43446362
83GABAergic synapse_Homo sapiens_hsa047270.43031550
84Circadian entrainment_Homo sapiens_hsa047130.43028525
85Ovarian steroidogenesis_Homo sapiens_hsa049130.42935514
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42308865
87Vitamin digestion and absorption_Homo sapiens_hsa049770.41997680
88Folate biosynthesis_Homo sapiens_hsa007900.41522931
89Serotonergic synapse_Homo sapiens_hsa047260.39517909
90Morphine addiction_Homo sapiens_hsa050320.38442469
91Long-term depression_Homo sapiens_hsa047300.38035846
92Glutamatergic synapse_Homo sapiens_hsa047240.37191806
93DNA replication_Homo sapiens_hsa030300.36891584
94Arachidonic acid metabolism_Homo sapiens_hsa005900.36604680
95Retinol metabolism_Homo sapiens_hsa008300.35061159
96Primary immunodeficiency_Homo sapiens_hsa053400.32639046
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29575394
98Dopaminergic synapse_Homo sapiens_hsa047280.29279756
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26560894
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25688790

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