ZNF236

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.16755652
2DNA methylation involved in gamete generation (GO:0043046)4.54519802
3establishment of protein localization to Golgi (GO:0072600)4.53516963
4interkinetic nuclear migration (GO:0022027)4.47483798
5monoubiquitinated protein deubiquitination (GO:0035520)4.46034050
6histone H3-K4 trimethylation (GO:0080182)4.26752297
7protein targeting to Golgi (GO:0000042)4.06954716
8negative regulation of cAMP-mediated signaling (GO:0043951)4.04975882
9regulation of RNA export from nucleus (GO:0046831)3.98849641
10retrograde transport, vesicle recycling within Golgi (GO:0000301)3.95387200
11gene silencing by RNA (GO:0031047)3.94443529
12regulation of hippo signaling (GO:0035330)3.89471777
13histone H3-K36 demethylation (GO:0070544)3.87833860
14protein K11-linked deubiquitination (GO:0035871)3.86727572
15histone H2A acetylation (GO:0043968)3.80571815
16mitotic sister chromatid cohesion (GO:0007064)3.78271549
17DNA methylation (GO:0006306)3.75400636
18DNA alkylation (GO:0006305)3.75400636
19regulation of histone H3-K9 methylation (GO:0051570)3.71347617
20regulation of translation, ncRNA-mediated (GO:0045974)3.66787950
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.66787950
22negative regulation of translation, ncRNA-mediated (GO:0040033)3.66787950
23peptidyl-lysine trimethylation (GO:0018023)3.66666006
24microtubule nucleation (GO:0007020)3.55219654
25histone H3-K9 demethylation (GO:0033169)3.51070376
26oocyte development (GO:0048599)3.44708594
27negative regulation of histone methylation (GO:0031061)3.35588457
28regulation of meiosis I (GO:0060631)3.32913124
29gene silencing (GO:0016458)3.31866996
30histone H3-K4 methylation (GO:0051568)3.27333674
31histone lysine methylation (GO:0034968)3.27276597
32centriole replication (GO:0007099)3.24363390
33protein K48-linked deubiquitination (GO:0071108)3.21490804
34synapsis (GO:0007129)3.12197816
35peptidyl-lysine methylation (GO:0018022)3.07844299
36positive regulation by host of viral transcription (GO:0043923)3.06204569
37nuclear pore complex assembly (GO:0051292)3.02678058
38regulation of centriole replication (GO:0046599)3.01789280
39regulation of histone H3-K4 methylation (GO:0051569)2.98232829
40Golgi to endosome transport (GO:0006895)2.98027735
41sister chromatid cohesion (GO:0007062)2.97474181
42snRNA transcription (GO:0009301)2.96914718
43cytoplasmic mRNA processing body assembly (GO:0033962)2.96278085
44DNA synthesis involved in DNA repair (GO:0000731)2.94099221
45positive regulation of histone H3-K4 methylation (GO:0051571)2.94064598
46histone H3-K9 methylation (GO:0051567)2.91766905
47regulation of histone methylation (GO:0031060)2.91491055
48chromatin silencing (GO:0006342)2.90171595
49DNA methylation or demethylation (GO:0044728)2.88597125
50regulation of establishment of cell polarity (GO:2000114)2.86778964
51phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.85994477
52protein localization to Golgi apparatus (GO:0034067)2.85988941
53meiotic chromosome segregation (GO:0045132)2.85888947
54positive regulation of protein homodimerization activity (GO:0090073)2.85059396
55regulation of nucleobase-containing compound transport (GO:0032239)2.84343286
56retina layer formation (GO:0010842)2.80234566
57centriole assembly (GO:0098534)2.79978976
58regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.79687796
59positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.79687796
60histone lysine demethylation (GO:0070076)2.77944871
61central nervous system neuron axonogenesis (GO:0021955)2.75659345
62histone demethylation (GO:0016577)2.74370340
63negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73328856
64regulation of DNA endoreduplication (GO:0032875)2.71757398
65histone H3-K9 modification (GO:0061647)2.69680851
66positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68669708
67embryonic body morphogenesis (GO:0010172)2.66307370
68histone H4-K16 acetylation (GO:0043984)2.66263118
69nucleus localization (GO:0051647)2.65907410
70central nervous system projection neuron axonogenesis (GO:0021952)2.65180168
71TOR signaling (GO:0031929)2.64250071
72microtubule anchoring (GO:0034453)2.63809761
73negative regulation of gene expression, epigenetic (GO:0045814)2.61350827
74neuron maturation (GO:0042551)2.55426884
75acrosome reaction (GO:0007340)2.55180374
76positive regulation of histone methylation (GO:0031062)2.54762654
77cilium or flagellum-dependent cell motility (GO:0001539)2.54245008
78positive T cell selection (GO:0043368)2.54079404
79V(D)J recombination (GO:0033151)2.53748289
80histone deubiquitination (GO:0016578)2.52773139
81histone methylation (GO:0016571)2.52507626
82regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.51720670
83positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.51720670
84regulation of pigment cell differentiation (GO:0050932)2.51406644
85positive regulation of meiosis (GO:0045836)2.51282921
86cAMP catabolic process (GO:0006198)2.49161433
87cerebellar Purkinje cell differentiation (GO:0021702)2.49103736
88chromosome organization involved in meiosis (GO:0070192)2.48615267
89pre-miRNA processing (GO:0031054)2.48142469
90sperm motility (GO:0030317)2.47842165
91histone mRNA catabolic process (GO:0071044)2.44510402
92cyclic nucleotide catabolic process (GO:0009214)2.44476378
93cellular response to ethanol (GO:0071361)2.43932957
94male meiosis (GO:0007140)2.43924799
95female gamete generation (GO:0007292)2.43475889
96cerebral cortex radially oriented cell migration (GO:0021799)2.43173041
97embryonic hemopoiesis (GO:0035162)2.42989416
98hindbrain development (GO:0030902)2.42542411
99positive regulation of developmental pigmentation (GO:0048087)2.42355235
100protein dealkylation (GO:0008214)2.41613465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.91739414
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.83959797
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.27782137
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.06093672
5GATA1_22025678_ChIP-Seq_K562_Human2.95715555
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90491783
7GBX2_23144817_ChIP-Seq_PC3_Human2.69256336
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54399850
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.51254418
10FUS_26573619_Chip-Seq_HEK293_Human2.38589768
11ZNF274_21170338_ChIP-Seq_K562_Hela2.32981951
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14137855
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10070065
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09559107
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95017822
16STAT3_23295773_ChIP-Seq_U87_Human1.92271973
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.91165459
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91051570
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90288689
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85626140
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84094808
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80111208
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78528012
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.78528012
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.77185857
26EWS_26573619_Chip-Seq_HEK293_Human1.76023636
27VDR_22108803_ChIP-Seq_LS180_Human1.74541685
28* TCF4_23295773_ChIP-Seq_U87_Human1.74204523
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72862448
30SMAD4_21799915_ChIP-Seq_A2780_Human1.70954888
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66390198
32TAF15_26573619_Chip-Seq_HEK293_Human1.64945061
33AHR_22903824_ChIP-Seq_MCF-7_Human1.63534630
34IGF1R_20145208_ChIP-Seq_DFB_Human1.61661410
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59922380
36ER_23166858_ChIP-Seq_MCF-7_Human1.59881477
37AR_21572438_ChIP-Seq_LNCaP_Human1.59362746
38* P300_19829295_ChIP-Seq_ESCs_Human1.56754146
39AR_25329375_ChIP-Seq_VCAP_Human1.56617732
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55845790
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55532693
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.53280950
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52766547
44TP53_16413492_ChIP-PET_HCT116_Human1.52532794
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.52001728
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51067838
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51013609
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48920143
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47035779
50CBP_20019798_ChIP-Seq_JUKART_Human1.47035779
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45684369
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44963707
53BCAT_22108803_ChIP-Seq_LS180_Human1.44690379
54* RUNX2_22187159_ChIP-Seq_PCA_Human1.41945167
55DROSHA_22980978_ChIP-Seq_HELA_Human1.40471516
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.38193013
57E2F7_22180533_ChIP-Seq_HELA_Human1.35361995
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32697692
59* RUNX_20019798_ChIP-Seq_JUKART_Human1.27735473
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26333529
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.25964898
62* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25915675
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.23942301
64KDM2B_26808549_Chip-Seq_REH_Human1.23304653
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.23237147
66FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19938661
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19298955
68TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18831833
69TCF4_22108803_ChIP-Seq_LS180_Human1.18084090
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15698893
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12243796
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.11553585
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11444541
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11173236
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.09758654
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09509701
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08370391
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07634089
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06838791
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.06104537
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04519416
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.04275528
83AR_19668381_ChIP-Seq_PC3_Human1.04006181
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03379605
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03358176
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.02442711
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01742158
88RXR_22108803_ChIP-Seq_LS180_Human1.00968511
89IRF1_19129219_ChIP-ChIP_H3396_Human1.00300355
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.00030645
91SCL_19346495_ChIP-Seq_HPC-7_Human0.99966684
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99888677
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98835871
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98785580
95SMRT_27268052_Chip-Seq_Bcells_Human0.98483546
96PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98053524
97* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97172103
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97078426
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96882141
100RNF2_27304074_Chip-Seq_NSC_Mouse0.95730037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.97946055
2MP0000569_abnormal_digit_pigmentation4.52170611
3MP0008877_abnormal_DNA_methylation4.30511095
4MP0000383_abnormal_hair_follicle2.65896665
5MP0003136_yellow_coat_color2.47904101
6MP0004381_abnormal_hair_follicle2.43616355
7MP0000427_abnormal_hair_cycle2.41871674
8MP0008995_early_reproductive_senescence1.98429825
9MP0004808_abnormal_hematopoietic_stem1.96436854
10MP0003787_abnormal_imprinting1.96405327
11MP0000015_abnormal_ear_pigmentation1.94173515
12MP0003763_abnormal_thymus_physiology1.93366893
13MP0005451_abnormal_body_composition1.91129575
14MP0005397_hematopoietic_system_phenotyp1.88666984
15MP0001545_abnormal_hematopoietic_system1.88666984
16MP0010678_abnormal_skin_adnexa1.88486952
17MP0005409_darkened_coat_color1.76166156
18MP0001486_abnormal_startle_reflex1.74374926
19MP0001929_abnormal_gametogenesis1.62112119
20MP0003698_abnormal_male_reproductive1.59334531
21MP0000372_irregular_coat_pigmentation1.58033257
22MP0002822_catalepsy1.55510565
23MP0003943_abnormal_hepatobiliary_system1.53034964
24MP0002210_abnormal_sex_determination1.52264970
25MP0002928_abnormal_bile_duct1.51578630
26MP0005646_abnormal_pituitary_gland1.50794852
27MP0000631_abnormal_neuroendocrine_gland1.48786042
28MP0005174_abnormal_tail_pigmentation1.41038899
29MP0006292_abnormal_olfactory_placode1.38609169
30MP0000778_abnormal_nervous_system1.38123214
31MP0010094_abnormal_chromosome_stability1.38120729
32MP0002095_abnormal_skin_pigmentation1.35673930
33MP0003646_muscle_fatigue1.35401188
34MP0001986_abnormal_taste_sensitivity1.34272805
35MP0002102_abnormal_ear_morphology1.33781929
36MP0005551_abnormal_eye_electrophysiolog1.28949257
37MP0002009_preneoplasia1.27785650
38MP0001188_hyperpigmentation1.27445318
39MP0008961_abnormal_basal_metabolism1.27355422
40MP0010307_abnormal_tumor_latency1.26349047
41MP0005379_endocrine/exocrine_gland_phen1.26216533
42MP0002160_abnormal_reproductive_system1.19706833
43MP0003890_abnormal_embryonic-extraembry1.19090268
44MP0002163_abnormal_gland_morphology1.18708663
45MP0003786_premature_aging1.18393410
46MP0002138_abnormal_hepatobiliary_system1.17824345
47MP0009703_decreased_birth_body1.14792171
48MP0003121_genomic_imprinting1.14290656
49MP0008058_abnormal_DNA_repair1.11959945
50MP0002075_abnormal_coat/hair_pigmentati1.11747614
51MP0001145_abnormal_male_reproductive1.11414477
52MP0005187_abnormal_penis_morphology1.06768469
53MP0000653_abnormal_sex_gland1.05517198
54MP0003935_abnormal_craniofacial_develop1.02900758
55MP0004134_abnormal_chest_morphology1.00077364
56MP0003937_abnormal_limbs/digits/tail_de0.93521285
57MP0005310_abnormal_salivary_gland0.92750515
58MP0001968_abnormal_touch/_nociception0.91021854
59MP0005410_abnormal_fertilization0.90840213
60MP0005075_abnormal_melanosome_morpholog0.89713117
61MP0000703_abnormal_thymus_morphology0.88331980
62MP0005389_reproductive_system_phenotype0.88188487
63MP0003635_abnormal_synaptic_transmissio0.83872766
64MP0005645_abnormal_hypothalamus_physiol0.82062487
65MP0002166_altered_tumor_susceptibility0.81781708
66MP0002067_abnormal_sensory_capabilities0.81476578
67MP0002084_abnormal_developmental_patter0.81011746
68MP0003861_abnormal_nervous_system0.80991821
69MP0003172_abnormal_lysosome_physiology0.80965108
70MP0002184_abnormal_innervation0.79943079
71MP0001485_abnormal_pinna_reflex0.79753466
72MP0001784_abnormal_fluid_regulation0.77017078
73MP0005220_abnormal_exocrine_pancreas0.76154737
74MP0005377_hearing/vestibular/ear_phenot0.75717425
75MP0003878_abnormal_ear_physiology0.75717425
76MP0005408_hypopigmentation0.75668824
77MP0005647_abnormal_sex_gland0.75314927
78MP0000647_abnormal_sebaceous_gland0.74164326
79MP0005367_renal/urinary_system_phenotyp0.73472119
80MP0000516_abnormal_urinary_system0.73472119
81MP0002132_abnormal_respiratory_system0.73407420
82MP0004742_abnormal_vestibular_system0.73205243
83MP0003385_abnormal_body_wall0.73032028
84MP0002063_abnormal_learning/memory/cond0.72390995
85MP0001119_abnormal_female_reproductive0.70022690
86MP0003045_fibrosis0.69913314
87MP0000371_diluted_coat_color0.69366396
88MP0002109_abnormal_limb_morphology0.68438627
89MP0010352_gastrointestinal_tract_polyps0.68378769
90MP0002161_abnormal_fertility/fecundity0.65370950
91MP0002396_abnormal_hematopoietic_system0.65221207
92MP0001270_distended_abdomen0.63730942
93MP0001186_pigmentation_phenotype0.63264511
94MP0009672_abnormal_birth_weight0.62974249
95MP0003077_abnormal_cell_cycle0.62870273
96MP0000470_abnormal_stomach_morphology0.62546852
97MP0002152_abnormal_brain_morphology0.62012155
98MP0002557_abnormal_social/conspecific_i0.61866800
99MP0004924_abnormal_behavior0.61090267
100MP0005386_behavior/neurological_phenoty0.61090267

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)3.60065839
2Hyperventilation (HP:0002883)3.55581423
3Genetic anticipation (HP:0003743)3.52234911
4Volvulus (HP:0002580)3.33441221
5Lip pit (HP:0100267)3.24365195
6Truncal obesity (HP:0001956)3.15900502
7Abnormality of the fingertips (HP:0001211)3.12286277
8Thyroiditis (HP:0100646)2.95631685
9Drooling (HP:0002307)2.69562016
10Ectopic kidney (HP:0000086)2.65979436
11Acute lymphatic leukemia (HP:0006721)2.63931465
12Hypoplastic iliac wings (HP:0002866)2.62840528
13Oligodactyly (hands) (HP:0001180)2.59392388
14Pancreatic cysts (HP:0001737)2.59320542
15Tubulointerstitial nephritis (HP:0001970)2.59044738
16Facial hemangioma (HP:0000329)2.58694897
17Menstrual irregularities (HP:0000858)2.55825649
18Progressive cerebellar ataxia (HP:0002073)2.54399009
19Fair hair (HP:0002286)2.54075248
20Hypoplastic nipples (HP:0002557)2.52893623
21Pancreatic fibrosis (HP:0100732)2.50295549
22Gaze-evoked nystagmus (HP:0000640)2.49745794
23Excessive salivation (HP:0003781)2.49327156
24Abnormality of incisor morphology (HP:0011063)2.45432990
25Macroorchidism (HP:0000053)2.45304593
26Acute myeloid leukemia (HP:0004808)2.42647119
27Heterotopia (HP:0002282)2.41590945
28Severe visual impairment (HP:0001141)2.38219195
29Protruding tongue (HP:0010808)2.36566888
30Widely spaced teeth (HP:0000687)2.33405757
31Nephronophthisis (HP:0000090)2.33103393
32Molar tooth sign on MRI (HP:0002419)2.30998615
33Abnormality of midbrain morphology (HP:0002418)2.30998615
34Anhidrosis (HP:0000970)2.30733466
35Abnormality of the renal medulla (HP:0100957)2.28993595
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28505886
37Papillary thyroid carcinoma (HP:0002895)2.27330643
38Hepatoblastoma (HP:0002884)2.23705617
39Abnormal hair whorl (HP:0010721)2.21706943
40Abnormality of the labia majora (HP:0012881)2.21575548
41Severe combined immunodeficiency (HP:0004430)2.21019698
42Abnormality of the incisor (HP:0000676)2.11040964
43Hypoplastic pelvis (HP:0008839)2.06506358
44Hypoplastic labia majora (HP:0000059)2.05212098
45Intellectual disability, moderate (HP:0002342)2.03391259
46Panhypogammaglobulinemia (HP:0003139)2.02126362
47Hyperkalemia (HP:0002153)2.00679181
48Abnormality of the columella (HP:0009929)2.00675572
49Aqueductal stenosis (HP:0002410)1.99607157
50T lymphocytopenia (HP:0005403)1.99507282
51Narrow palate (HP:0000189)1.97439121
52Cystic liver disease (HP:0006706)1.97196801
53Abnormality of the renal cortex (HP:0011035)1.96327117
54Obsessive-compulsive behavior (HP:0000722)1.95463870
55Generalized hypopigmentation of hair (HP:0011358)1.94501382
56Sandal gap (HP:0001852)1.93742978
57True hermaphroditism (HP:0010459)1.90372742
58Neoplasm of the oral cavity (HP:0100649)1.89288432
59Long eyelashes (HP:0000527)1.88061920
60Oligodontia (HP:0000677)1.87607449
61Abnormality of T cell number (HP:0011839)1.84837785
62Chromsome breakage (HP:0040012)1.83898417
63Deep palmar crease (HP:0006191)1.83371289
64Broad-based gait (HP:0002136)1.83281638
65Hypoplasia of the thymus (HP:0000778)1.82580831
66Hip dysplasia (HP:0001385)1.82502142
67Proximal tubulopathy (HP:0000114)1.80979064
68Pendular nystagmus (HP:0012043)1.80401374
69Tapered finger (HP:0001182)1.80015453
70Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74670571
71Abnormality of the nasal septum (HP:0000419)1.74185301
72Abnormality of the ischium (HP:0003174)1.72690308
73Short chin (HP:0000331)1.71826784
74Cone-rod dystrophy (HP:0000548)1.71271374
75Aplasia/Hypoplasia of the nipples (HP:0006709)1.70828169
76Highly arched eyebrow (HP:0002553)1.70552390
77Neoplasm of the adrenal cortex (HP:0100641)1.70444482
78Preaxial hand polydactyly (HP:0001177)1.70127221
79Tented upper lip vermilion (HP:0010804)1.70018292
80Absent eyebrow (HP:0002223)1.69676866
81Abnormality of DNA repair (HP:0003254)1.69183996
82Hypoplasia of the maxilla (HP:0000327)1.69151352
83Abnormality of B cell number (HP:0010975)1.69146572
84Poor eye contact (HP:0000817)1.67984101
85Oligodactyly (HP:0012165)1.67162521
86Deep philtrum (HP:0002002)1.67006357
87Cupped ear (HP:0000378)1.66559462
88Intestinal atresia (HP:0011100)1.65996477
89Tubular atrophy (HP:0000092)1.65065850
90Chin dimple (HP:0010751)1.64472019
91Abnormality of the metopic suture (HP:0005556)1.63210917
92Broad face (HP:0000283)1.62255627
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.61273053
94Submucous cleft hard palate (HP:0000176)1.61045753
95Abnormality of chromosome stability (HP:0003220)1.60830238
96Optic nerve hypoplasia (HP:0000609)1.59776532
97B lymphocytopenia (HP:0010976)1.59735253
98Aplasia/Hypoplasia of the earlobes (HP:0009906)1.59715812
99Laryngomalacia (HP:0001601)1.59037321
100Small hand (HP:0200055)1.57313396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.61071930
2PNCK3.32384451
3AKT32.97505931
4CAMK1G2.85993415
5MAP3K42.77304640
6BRD42.59303791
7CDK122.55842940
8TNIK2.37151626
9NLK2.24879633
10FGFR22.05617774
11TAOK32.02898776
12SGK21.99765731
13STK38L1.86299018
14CASK1.79439378
15WNK11.69194708
16MAP3K71.59442380
17TYRO31.59180987
18MARK21.56670049
19CAMK1D1.49945319
20MAPK131.45782667
21STK391.39497498
22NUAK11.31815436
23PLK41.31294709
24INSRR1.31206873
25SGK31.22691132
26FGFR31.15934355
27TNK21.15479723
28NTRK21.11474406
29ACVR1B1.06397504
30MKNK21.04737843
31CDC71.03175014
32SGK2231.02833556
33SGK4941.02833556
34ZAK0.97078286
35MELK0.96888265
36STK110.96084484
37PRKD30.94025579
38MAP3K100.92680840
39PLK20.91710157
40BMPR1B0.88537268
41PAK30.86960322
42BLK0.84362884
43NEK60.82344492
44PTK2B0.82234915
45CAMK40.80352387
46CDK30.79749817
47FES0.79110272
48PIK3CG0.78509457
49PRKD20.78386009
50CAMK10.77525131
51CHEK10.76697082
52ATM0.75258036
53GRK10.71411006
54RPS6KB10.68224726
55TEC0.66985521
56MAPK70.65729509
57NTRK30.64087065
58SGK10.63981488
59PRKCH0.63886515
60DMPK0.63224975
61MTOR0.61943865
62MAPK100.61805067
63GSK3B0.61059278
64MAP3K60.60858919
65OXSR10.60613052
66ATR0.59017892
67MAPK80.58977141
68STK380.57584451
69OBSCN0.57549887
70BTK0.56369076
71MARK10.53297733
72PRKAA20.52768544
73HIPK20.51333987
74EPHA30.50657964
75RPS6KA60.50145319
76STK30.49948553
77ERBB20.49865913
78CDK20.49841042
79PDGFRB0.48622857
80PRKAA10.47748431
81TXK0.47460362
82RET0.45615086
83PDK10.44608368
84MAP4K10.43913539
85RPS6KL10.43714610
86RPS6KC10.43714610
87MAP2K40.43151152
88CDK10.43087743
89CSNK1D0.42855595
90MAPK140.42012345
91MUSK0.41859690
92STK240.41221559
93MAPK10.40973767
94CHUK0.40452736
95DYRK1A0.39789446
96MARK30.39624342
97RPS6KB20.39354810
98WNK30.39155787
99AKT10.38946169
100MAP2K70.38898242

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.26414630
2Fanconi anemia pathway_Homo sapiens_hsa034602.11795401
3Non-homologous end-joining_Homo sapiens_hsa034501.85447921
4Lysine degradation_Homo sapiens_hsa003101.70528876
5Type II diabetes mellitus_Homo sapiens_hsa049301.64959178
6Homologous recombination_Homo sapiens_hsa034401.59933000
7Phototransduction_Homo sapiens_hsa047441.58111379
8Taste transduction_Homo sapiens_hsa047421.57449596
9Regulation of autophagy_Homo sapiens_hsa041401.52468136
10mTOR signaling pathway_Homo sapiens_hsa041501.47642641
11Prostate cancer_Homo sapiens_hsa052151.43045337
12Circadian rhythm_Homo sapiens_hsa047101.41460838
13FoxO signaling pathway_Homo sapiens_hsa040681.33896761
14Choline metabolism in cancer_Homo sapiens_hsa052311.32470927
15B cell receptor signaling pathway_Homo sapiens_hsa046621.30648235
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29468483
17Nicotine addiction_Homo sapiens_hsa050331.27919333
18Non-small cell lung cancer_Homo sapiens_hsa052231.23963024
19Endometrial cancer_Homo sapiens_hsa052131.21786205
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19165445
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18526088
22Prolactin signaling pathway_Homo sapiens_hsa049171.18469429
23Hedgehog signaling pathway_Homo sapiens_hsa043401.17887717
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17354058
25T cell receptor signaling pathway_Homo sapiens_hsa046601.17029031
26Alcoholism_Homo sapiens_hsa050341.16424226
27Acute myeloid leukemia_Homo sapiens_hsa052211.16249754
28ABC transporters_Homo sapiens_hsa020101.15889022
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.15797773
30Inositol phosphate metabolism_Homo sapiens_hsa005621.14124417
31MicroRNAs in cancer_Homo sapiens_hsa052061.10115365
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09622504
33ErbB signaling pathway_Homo sapiens_hsa040121.04904164
34Selenocompound metabolism_Homo sapiens_hsa004501.03558961
35Morphine addiction_Homo sapiens_hsa050321.02772765
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02425721
37Glutamatergic synapse_Homo sapiens_hsa047241.01461999
38Colorectal cancer_Homo sapiens_hsa052101.00682466
39Long-term potentiation_Homo sapiens_hsa047201.00582509
40Calcium signaling pathway_Homo sapiens_hsa040201.00237236
41Cocaine addiction_Homo sapiens_hsa050300.97246832
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97061789
43cAMP signaling pathway_Homo sapiens_hsa040240.96870220
44Chronic myeloid leukemia_Homo sapiens_hsa052200.94786934
45mRNA surveillance pathway_Homo sapiens_hsa030150.93382117
46Circadian entrainment_Homo sapiens_hsa047130.92062763
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.91749957
48MAPK signaling pathway_Homo sapiens_hsa040100.91008277
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90880915
50Glioma_Homo sapiens_hsa052140.90736021
51Notch signaling pathway_Homo sapiens_hsa043300.89962347
52Wnt signaling pathway_Homo sapiens_hsa043100.89843493
53Cholinergic synapse_Homo sapiens_hsa047250.89711780
54RNA transport_Homo sapiens_hsa030130.88271383
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.88227997
56Renin secretion_Homo sapiens_hsa049240.86477478
57Olfactory transduction_Homo sapiens_hsa047400.86117312
58Dopaminergic synapse_Homo sapiens_hsa047280.85587222
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83682495
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.83441827
61Fatty acid biosynthesis_Homo sapiens_hsa000610.83435221
62Insulin secretion_Homo sapiens_hsa049110.82995814
63Systemic lupus erythematosus_Homo sapiens_hsa053220.82875980
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82654477
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82542063
66Axon guidance_Homo sapiens_hsa043600.81441337
67Insulin resistance_Homo sapiens_hsa049310.81122425
68Amphetamine addiction_Homo sapiens_hsa050310.79635293
69Primary immunodeficiency_Homo sapiens_hsa053400.77990700
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77477755
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77305301
72Cell cycle_Homo sapiens_hsa041100.74536286
73Oxytocin signaling pathway_Homo sapiens_hsa049210.74336291
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74308070
75Viral carcinogenesis_Homo sapiens_hsa052030.73771213
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72614263
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71070590
78Basal cell carcinoma_Homo sapiens_hsa052170.70247792
79Estrogen signaling pathway_Homo sapiens_hsa049150.67734369
80Oocyte meiosis_Homo sapiens_hsa041140.67449459
81Platelet activation_Homo sapiens_hsa046110.67039380
82Small cell lung cancer_Homo sapiens_hsa052220.66231252
83Renal cell carcinoma_Homo sapiens_hsa052110.66175716
84Basal transcription factors_Homo sapiens_hsa030220.65346977
85Pancreatic cancer_Homo sapiens_hsa052120.65322297
86AMPK signaling pathway_Homo sapiens_hsa041520.64709986
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64311579
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.64227758
89Ras signaling pathway_Homo sapiens_hsa040140.63029410
90Long-term depression_Homo sapiens_hsa047300.62051949
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60418079
92Hippo signaling pathway_Homo sapiens_hsa043900.57146245
93TGF-beta signaling pathway_Homo sapiens_hsa043500.56768309
94Pancreatic secretion_Homo sapiens_hsa049720.56521724
95Melanogenesis_Homo sapiens_hsa049160.55855404
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54727905
97Glucagon signaling pathway_Homo sapiens_hsa049220.54613700
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.52714404
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.52139016
100Pathways in cancer_Homo sapiens_hsa052000.51039000

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