ZNF239

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)4.89123818
2ribosome assembly (GO:0042255)4.75329321
3DNA double-strand break processing (GO:0000729)4.74854858
4synapsis (GO:0007129)4.36371885
5chromatin remodeling at centromere (GO:0031055)4.19885744
6mitotic sister chromatid cohesion (GO:0007064)4.19670599
7CENP-A containing nucleosome assembly (GO:0034080)4.18202988
8regulation of meiosis I (GO:0060631)4.12143002
9regulation of mitochondrial translation (GO:0070129)4.05135006
10establishment of integrated proviral latency (GO:0075713)3.92882025
11histone exchange (GO:0043486)3.80057878
12regulation of DNA endoreduplication (GO:0032875)3.71769133
13negative regulation of DNA-dependent DNA replication (GO:2000104)3.68048323
14IMP biosynthetic process (GO:0006188)3.65060569
15piRNA metabolic process (GO:0034587)3.58031177
16DNA replication-dependent nucleosome assembly (GO:0006335)3.55754180
17DNA replication-dependent nucleosome organization (GO:0034723)3.55754180
18DNA strand elongation involved in DNA replication (GO:0006271)3.45473224
19mitotic metaphase plate congression (GO:0007080)3.45438085
20protein K6-linked ubiquitination (GO:0085020)3.39034559
21pseudouridine synthesis (GO:0001522)3.38936975
22DNA strand elongation (GO:0022616)3.36952432
23chromosome organization involved in meiosis (GO:0070192)3.36586197
24regulation of centriole replication (GO:0046599)3.35316090
25DNA replication-independent nucleosome assembly (GO:0006336)3.34823886
26DNA replication-independent nucleosome organization (GO:0034724)3.34823886
27mitotic chromosome condensation (GO:0007076)3.33132346
28telomere maintenance via semi-conservative replication (GO:0032201)3.23702513
29negative regulation of meiosis (GO:0045835)3.21373578
30regulation of helicase activity (GO:0051095)3.18118162
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.17698766
32purine nucleobase biosynthetic process (GO:0009113)3.16941548
33protein localization to kinetochore (GO:0034501)3.13089023
34DNA catabolic process, exonucleolytic (GO:0000738)3.12971026
35folic acid-containing compound biosynthetic process (GO:0009396)3.09457003
36somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07519055
37somatic hypermutation of immunoglobulin genes (GO:0016446)3.07519055
38sister chromatid cohesion (GO:0007062)3.05174292
39IMP metabolic process (GO:0046040)3.03314231
40DNA unwinding involved in DNA replication (GO:0006268)3.01639658
41metaphase plate congression (GO:0051310)2.99921601
42termination of RNA polymerase III transcription (GO:0006386)2.98983863
43transcription elongation from RNA polymerase III promoter (GO:0006385)2.98983863
44respiratory chain complex IV assembly (GO:0008535)2.98011413
45nuclear pore complex assembly (GO:0051292)2.96800451
46nuclear pore organization (GO:0006999)2.96233884
47kinetochore organization (GO:0051383)2.95549537
48DNA damage response, detection of DNA damage (GO:0042769)2.94460277
49negative regulation of mitotic sister chromatid separation (GO:2000816)2.94423898
50negative regulation of sister chromatid segregation (GO:0033046)2.94423898
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94423898
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94423898
53negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94423898
54resolution of meiotic recombination intermediates (GO:0000712)2.94080164
55negative regulation of chromosome segregation (GO:0051985)2.93604023
56establishment of protein localization to mitochondrial membrane (GO:0090151)2.91250801
57spindle checkpoint (GO:0031577)2.87617373
58regulation of transcription from RNA polymerase I promoter (GO:0006356)2.87420440
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86099176
60DNA replication initiation (GO:0006270)2.85197064
61mitotic sister chromatid segregation (GO:0000070)2.84342236
62mitotic spindle checkpoint (GO:0071174)2.83430111
63L-serine metabolic process (GO:0006563)2.83042270
64telomere maintenance via recombination (GO:0000722)2.80575684
65mitotic recombination (GO:0006312)2.78479900
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78019990
67mitochondrial RNA metabolic process (GO:0000959)2.77838082
68nucleobase biosynthetic process (GO:0046112)2.77449611
69cytochrome complex assembly (GO:0017004)2.77291388
70male meiosis (GO:0007140)2.75120548
71ncRNA catabolic process (GO:0034661)2.74238452
72ubiquinone biosynthetic process (GO:0006744)2.73740930
73establishment of viral latency (GO:0019043)2.72876688
74mitotic spindle assembly checkpoint (GO:0007094)2.71921933
75spindle assembly checkpoint (GO:0071173)2.71406650
76DNA synthesis involved in DNA repair (GO:0000731)2.69106187
77rRNA modification (GO:0000154)2.67694687
78mitotic nuclear envelope disassembly (GO:0007077)2.67230214
79histone mRNA metabolic process (GO:0008334)2.66769004
80DNA methylation involved in gamete generation (GO:0043046)2.65396733
81negative regulation of nuclear division (GO:0051784)2.64913369
82regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64288070
83regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64288070
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63901193
85proteasome assembly (GO:0043248)2.63463334
86negative regulation of telomerase activity (GO:0051974)2.62563838
87regulation of chromosome segregation (GO:0051983)2.62328691
88telomere maintenance via telomere lengthening (GO:0010833)2.62155770
89sister chromatid segregation (GO:0000819)2.62019596
90pteridine-containing compound biosynthetic process (GO:0042559)2.61756055
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61619758
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61619758
93meiotic chromosome segregation (GO:0045132)2.61547614
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60900182
95regulation of centrosome cycle (GO:0046605)2.60820707
96ubiquinone metabolic process (GO:0006743)2.60815021
97meiotic nuclear division (GO:0007126)2.59357067
98ATP-dependent chromatin remodeling (GO:0043044)2.58607539
99regulation of mitotic sister chromatid segregation (GO:0033047)2.56313395
100regulation of sister chromatid segregation (GO:0033045)2.56313395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23727902
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19087129
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62612574
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.02545696
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.02435397
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.95634248
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93721752
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.79079812
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72265578
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.70360618
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68233251
12* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56054493
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38165258
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.33129137
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31071698
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30617576
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29780609
18ELK1_19687146_ChIP-ChIP_HELA_Human2.24461032
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21077483
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10948655
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09565567
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07499593
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.03177235
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93574689
25ZNF274_21170338_ChIP-Seq_K562_Hela1.90417775
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88946130
27AR_21909140_ChIP-Seq_LNCAP_Human1.86432606
28TTF2_22483619_ChIP-Seq_HELA_Human1.79557355
29EWS_26573619_Chip-Seq_HEK293_Human1.77942089
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77828019
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75679617
32DCP1A_22483619_ChIP-Seq_HELA_Human1.72577168
33FOXP3_21729870_ChIP-Seq_TREG_Human1.71788715
34VDR_23849224_ChIP-Seq_CD4+_Human1.71299302
35IGF1R_20145208_ChIP-Seq_DFB_Human1.68515819
36TAF15_26573619_Chip-Seq_HEK293_Human1.67495361
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66511534
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64168745
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62673086
40FUS_26573619_Chip-Seq_HEK293_Human1.62607398
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62349527
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59312252
43VDR_22108803_ChIP-Seq_LS180_Human1.58180678
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57274065
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56167495
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55942950
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48658527
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48427314
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47436630
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.47069525
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40901417
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40231605
53GABP_19822575_ChIP-Seq_HepG2_Human1.39675775
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.38318317
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37896072
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.37240151
57XRN2_22483619_ChIP-Seq_HELA_Human1.36975522
58MYC_18940864_ChIP-ChIP_HL60_Human1.36231193
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.34600111
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29658785
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29264742
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.28498759
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.27086617
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26819274
65KDM5A_27292631_Chip-Seq_BREAST_Human1.26790691
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26116158
67* NOTCH1_21737748_ChIP-Seq_TLL_Human1.23293685
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22679170
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20954956
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19032235
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16853777
72GBX2_23144817_ChIP-Seq_PC3_Human1.08702409
73P300_19829295_ChIP-Seq_ESCs_Human1.08698599
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07222414
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06688767
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03717261
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00435218
78NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95178991
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94534271
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93564479
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91536090
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91286633
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89058509
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87731332
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87688558
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85544658
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85423796
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85322858
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84736457
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84673733
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.84429280
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81504052
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77586942
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77586942
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77586942
96RNF2_27304074_Chip-Seq_NSC_Mouse0.75845870
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.73051971
98CHD1_26751641_Chip-Seq_LNCaP_Human0.72329086
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71476493
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69142458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.92082783
2MP0008057_abnormal_DNA_replication3.70741647
3MP0008877_abnormal_DNA_methylation3.57232856
4MP0010094_abnormal_chromosome_stability3.52743547
5MP0008058_abnormal_DNA_repair3.15697191
6MP0006292_abnormal_olfactory_placode2.80021077
7MP0004957_abnormal_blastocyst_morpholog2.72139331
8MP0003111_abnormal_nucleus_morphology2.52553749
9MP0008007_abnormal_cellular_replicative2.51692180
10MP0003718_maternal_effect2.48296626
11MP0003077_abnormal_cell_cycle2.48165989
12MP0003941_abnormal_skin_development2.40873536
13MP0008004_abnormal_stomach_pH2.29312112
14MP0002837_dystrophic_cardiac_calcinosis2.21870373
15MP0006035_abnormal_mitochondrial_morpho2.18971938
16MP0008932_abnormal_embryonic_tissue2.15912663
17MP0002736_abnormal_nociception_after1.83575260
18MP0003567_abnormal_fetal_cardiomyocyte1.80638787
19MP0001730_embryonic_growth_arrest1.74908812
20MP0003937_abnormal_limbs/digits/tail_de1.69850311
21MP0003186_abnormal_redox_activity1.59056919
22MP0009780_abnormal_chondrocyte_physiolo1.58214577
23MP0002210_abnormal_sex_determination1.53902216
24MP0002160_abnormal_reproductive_system1.51451886
25MP0002909_abnormal_adrenal_gland1.44756604
26MP0001929_abnormal_gametogenesis1.41543378
27MP0002102_abnormal_ear_morphology1.37888057
28MP0003123_paternal_imprinting1.36533704
29MP0000350_abnormal_cell_proliferation1.31864939
30MP0000358_abnormal_cell_content/1.31830856
31MP0000013_abnormal_adipose_tissue1.28212156
32MP0003806_abnormal_nucleotide_metabolis1.24267458
33MP0001145_abnormal_male_reproductive1.24073779
34MP0002085_abnormal_embryonic_tissue1.23502198
35MP0000653_abnormal_sex_gland1.22320269
36MP0001697_abnormal_embryo_size1.22204659
37MP0002084_abnormal_developmental_patter1.18574375
38MP0008789_abnormal_olfactory_epithelium1.18302872
39MP0009697_abnormal_copulation1.18124076
40MP0003121_genomic_imprinting1.17357597
41MP0003890_abnormal_embryonic-extraembry1.16730519
42MP0004264_abnormal_extraembryonic_tissu1.12484154
43MP0004133_heterotaxia1.12135317
44MP0003786_premature_aging1.09253255
45MP0006036_abnormal_mitochondrial_physio1.08661779
46MP0001177_atelectasis1.07307392
47MP0009672_abnormal_birth_weight1.06832813
48MP0001188_hyperpigmentation1.02197486
49MP0000631_abnormal_neuroendocrine_gland1.01498852
50MP0001529_abnormal_vocalization1.00769335
51MP0002139_abnormal_hepatobiliary_system0.99880408
52MP0001672_abnormal_embryogenesis/_devel0.98469714
53MP0005380_embryogenesis_phenotype0.98469714
54MP0003221_abnormal_cardiomyocyte_apopto0.97534658
55MP0000049_abnormal_middle_ear0.97391303
56MP0003698_abnormal_male_reproductive0.95679627
57MP0002233_abnormal_nose_morphology0.95301856
58MP0000647_abnormal_sebaceous_gland0.93562193
59MP0004197_abnormal_fetal_growth/weight/0.92182532
60MP0003755_abnormal_palate_morphology0.90863915
61MP0002249_abnormal_larynx_morphology0.89948259
62MP0001968_abnormal_touch/_nociception0.89702238
63MP0008995_early_reproductive_senescence0.89170165
64MP0000428_abnormal_craniofacial_morphol0.88979321
65MP0009703_decreased_birth_body0.87010791
66MP0010307_abnormal_tumor_latency0.86324715
67MP0002080_prenatal_lethality0.86057299
68MP0003119_abnormal_digestive_system0.85985359
69MP0006072_abnormal_retinal_apoptosis0.85029939
70MP0002177_abnormal_outer_ear0.82669184
71MP0005395_other_phenotype0.80152921
72MP0002254_reproductive_system_inflammat0.79671919
73MP0003935_abnormal_craniofacial_develop0.78214368
74MP0000678_abnormal_parathyroid_gland0.78145983
75MP0001661_extended_life_span0.77117797
76MP0003984_embryonic_growth_retardation0.77064857
77MP0002234_abnormal_pharynx_morphology0.76086638
78MP0002088_abnormal_embryonic_growth/wei0.76031925
79MP0002184_abnormal_innervation0.75718450
80MP0001346_abnormal_lacrimal_gland0.75530228
81MP0010030_abnormal_orbit_morphology0.75013627
82MP0002269_muscular_atrophy0.74340874
83MP0003699_abnormal_female_reproductive0.74065146
84MP0000462_abnormal_digestive_system0.73535608
85MP0003861_abnormal_nervous_system0.73330466
86MP0003787_abnormal_imprinting0.72557623
87MP0001293_anophthalmia0.71444576
88MP0000313_abnormal_cell_death0.70623148
89MP0002796_impaired_skin_barrier0.69992402
90MP0002161_abnormal_fertility/fecundity0.69565484
91MP0003137_abnormal_impulse_conducting0.69174688
92MP0004145_abnormal_muscle_electrophysio0.69153187
93MP0009046_muscle_twitch0.67795542
94MP0005389_reproductive_system_phenotype0.67139620
95MP0002751_abnormal_autonomic_nervous0.67078699
96MP0000579_abnormal_nail_morphology0.65950156
97MP0003938_abnormal_ear_development0.64819456
98MP0009250_abnormal_appendicular_skeleto0.64471368
99MP0001119_abnormal_female_reproductive0.64254266
100MP0002111_abnormal_tail_morphology0.62498236

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.33169631
2Volvulus (HP:0002580)3.33415271
3Chromsome breakage (HP:0040012)3.32147160
4Osteomalacia (HP:0002749)3.25912764
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22671274
6Reduced antithrombin III activity (HP:0001976)3.16444957
7Meckel diverticulum (HP:0002245)3.10274779
8Type I transferrin isoform profile (HP:0003642)2.97114095
9Abnormality of the preputium (HP:0100587)2.92382858
10Abnormality of chromosome stability (HP:0003220)2.86784972
11Abnormality of the ileum (HP:0001549)2.84792232
12Neuroendocrine neoplasm (HP:0100634)2.68778283
13Renal Fanconi syndrome (HP:0001994)2.63702689
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.63240808
15Septate vagina (HP:0001153)2.60235913
16Central scotoma (HP:0000603)2.44820465
17Neoplasm of the oral cavity (HP:0100649)2.43545580
18Papillary thyroid carcinoma (HP:0002895)2.41390613
19Neoplasm of the adrenal gland (HP:0100631)2.37569575
20Facial hemangioma (HP:0000329)2.35569293
21J-shaped sella turcica (HP:0002680)2.33287182
22Shoulder girdle muscle weakness (HP:0003547)2.30296699
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30015558
24Abnormal protein N-linked glycosylation (HP:0012347)2.30015558
25Abnormal protein glycosylation (HP:0012346)2.30015558
26Abnormal glycosylation (HP:0012345)2.30015558
27Menstrual irregularities (HP:0000858)2.27828513
28Pheochromocytoma (HP:0002666)2.27292828
29Abnormality of the intrinsic pathway (HP:0010989)2.22610931
30CNS hypomyelination (HP:0003429)2.20829510
31Colon cancer (HP:0003003)2.18547715
32Horseshoe kidney (HP:0000085)2.18476925
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16670437
34Gonadotropin excess (HP:0000837)2.16102203
35Absent radius (HP:0003974)2.15393360
36Biliary tract neoplasm (HP:0100574)2.15144408
37Ectopic kidney (HP:0000086)2.14717888
38Increased CSF lactate (HP:0002490)2.12757116
39Acute necrotizing encephalopathy (HP:0006965)2.12172408
40Poor speech (HP:0002465)2.10077475
41Acute encephalopathy (HP:0006846)2.08492005
42Dyschromatopsia (HP:0007641)2.06542713
43Abnormal lung lobation (HP:0002101)2.06001347
44Abnormality of methionine metabolism (HP:0010901)2.05447171
45Birth length less than 3rd percentile (HP:0003561)2.03873247
46Scotoma (HP:0000575)2.03153341
47Duodenal stenosis (HP:0100867)2.02322939
48Small intestinal stenosis (HP:0012848)2.02322939
49Abdominal situs inversus (HP:0003363)1.99570227
50Abnormality of abdominal situs (HP:0011620)1.99570227
51Absent forearm bone (HP:0003953)1.99434309
52Aplasia involving forearm bones (HP:0009822)1.99434309
53Hypoglycemic seizures (HP:0002173)1.98308894
54Methylmalonic acidemia (HP:0002912)1.95616765
55Progressive inability to walk (HP:0002505)1.95028068
56Increased nuchal translucency (HP:0010880)1.92795236
57Supernumerary spleens (HP:0009799)1.92018878
58Delayed myelination (HP:0012448)1.91915714
59Poor eye contact (HP:0000817)1.90441002
60Horizontal nystagmus (HP:0000666)1.88460716
61Abnormality of the septum pellucidum (HP:0007375)1.88357011
62Microvesicular hepatic steatosis (HP:0001414)1.88256383
63Abnormality of the duodenum (HP:0002246)1.88132185
64Hyperglycinemia (HP:0002154)1.87502357
65Carpal bone hypoplasia (HP:0001498)1.84479976
66Esophageal atresia (HP:0002032)1.84155470
67Rectal fistula (HP:0100590)1.83261464
68Rectovaginal fistula (HP:0000143)1.83261464
69Increased hepatocellular lipid droplets (HP:0006565)1.81703888
70Abnormal mitochondria in muscle tissue (HP:0008316)1.81252072
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80920061
72Median cleft lip (HP:0000161)1.80500099
73Fibular aplasia (HP:0002990)1.79721009
74Progressive macrocephaly (HP:0004481)1.77270815
75Mitochondrial inheritance (HP:0001427)1.76013532
76Ovarian neoplasm (HP:0100615)1.74961191
77Abnormality of serine family amino acid metabolism (HP:0010894)1.74116251
78Abnormality of glycine metabolism (HP:0010895)1.74116251
79Abnormality of calcium-phosphate metabolism (HP:0100530)1.73702602
80Hyperglycinuria (HP:0003108)1.73046854
81Abnormal number of incisors (HP:0011064)1.72466895
82Neoplasm of the small intestine (HP:0100833)1.72399231
83Abnormality of vitamin metabolism (HP:0100508)1.70949979
84Multiple enchondromatosis (HP:0005701)1.69327708
85Cerebral hypomyelination (HP:0006808)1.69198833
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68463713
87Cerebral edema (HP:0002181)1.68320271
88Abnormality of the anterior horn cell (HP:0006802)1.68087247
89Degeneration of anterior horn cells (HP:0002398)1.68087247
90Severe visual impairment (HP:0001141)1.67218262
91Proximal placement of thumb (HP:0009623)1.66960043
92Ependymoma (HP:0002888)1.66684178
93Sloping forehead (HP:0000340)1.65617677
94Septo-optic dysplasia (HP:0100842)1.65572416
95Neoplasm of the colon (HP:0100273)1.64814754
96Arteriovenous malformation (HP:0100026)1.64607850
97Abnormality of macular pigmentation (HP:0008002)1.62474078
98Increased serum lactate (HP:0002151)1.61891385
99Triphalangeal thumb (HP:0001199)1.61544236
100Hypoplastic pelvis (HP:0008839)1.61520996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.09262526
2SRPK13.57633830
3TTK3.42729276
4CDC73.25929912
5BUB12.78464316
6TSSK62.59470732
7EIF2AK12.47082690
8BRSK22.40998375
9MAP2K32.25494858
10PBK2.23919728
11MAP2K62.23341109
12MKNK22.21201874
13VRK22.06124595
14PLK32.05815707
15MST42.05693384
16ZAK2.00885017
17PLK41.89750152
18WNK31.85729268
19WEE11.73926803
20VRK11.68521263
21PLK11.66889245
22EIF2AK31.66829588
23ACVR1B1.66813674
24PINK11.58742757
25MAP2K41.56628263
26TNIK1.55176623
27PNCK1.46067812
28MKNK11.43773142
29STK161.43464154
30CASK1.39954612
31TRIM281.34014905
32CDK31.33937819
33CHEK21.32899335
34BRSK11.31749155
35ALK1.31105085
36ATR1.30700405
37NUAK11.27434844
38NME11.17289367
39MAP3K51.16369711
40NEK11.14641241
41MINK11.07571799
42AURKB1.05075005
43RPS6KB21.02917855
44ATM1.02862944
45PRKD30.99758452
46DMPK0.95780310
47STK38L0.91009068
48BCKDK0.85976071
49MAPK130.85489055
50CCNB10.83560716
51CHEK10.82455566
52BMPR1B0.80291654
53ERBB40.79860705
54CSNK1G10.79855605
55PASK0.79256545
56WNK40.78922942
57PLK20.77424616
58CAMK1G0.75201022
59CSNK1G20.73021970
60AURKA0.70965566
61STK30.70343679
62STK40.63307199
63TAF10.63193302
64ERBB30.62293835
65YES10.60647794
66CSNK1G30.59933956
67CDK10.59443967
68MAP4K20.57180770
69MAP3K80.54419935
70PRKDC0.53755424
71CSNK1E0.53691508
72CDK20.51332980
73PRKCI0.49718066
74MAP3K40.45996752
75CSNK2A10.44608615
76GRK10.44113906
77CDK70.43015875
78CAMK1D0.42819369
79TLK10.42119513
80CAMKK20.41972225
81CDK80.41856221
82BCR0.41691884
83NME20.41343036
84CSNK2A20.40198490
85EIF2AK20.39989580
86DYRK20.39467868
87SCYL20.37561862
88NEK60.37045184
89EEF2K0.35875179
90CSNK1A1L0.35236321
91PRKCE0.34704871
92RPS6KA40.34061779
93DYRK30.31170294
94NTRK30.27847811
95RET0.27070855
96CDK190.26980774
97OXSR10.25814600
98RPS6KB10.25399397
99FRK0.24446614
100ADRBK10.24421785

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.32266515
2Mismatch repair_Homo sapiens_hsa034303.24723085
3Proteasome_Homo sapiens_hsa030503.08294627
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02050161
5RNA polymerase_Homo sapiens_hsa030202.99318728
6Non-homologous end-joining_Homo sapiens_hsa034502.96192248
7Protein export_Homo sapiens_hsa030602.58580950
8Selenocompound metabolism_Homo sapiens_hsa004502.57790239
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57472539
10RNA transport_Homo sapiens_hsa030132.47045883
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42939373
12Homologous recombination_Homo sapiens_hsa034402.36482733
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31557338
14Fanconi anemia pathway_Homo sapiens_hsa034602.13987098
15Spliceosome_Homo sapiens_hsa030401.94577260
16One carbon pool by folate_Homo sapiens_hsa006701.91570543
17Cell cycle_Homo sapiens_hsa041101.84767726
18Nucleotide excision repair_Homo sapiens_hsa034201.83816005
19Basal transcription factors_Homo sapiens_hsa030221.79392277
20Oxidative phosphorylation_Homo sapiens_hsa001901.78871162
21Pyrimidine metabolism_Homo sapiens_hsa002401.76749474
22RNA degradation_Homo sapiens_hsa030181.75825870
23mRNA surveillance pathway_Homo sapiens_hsa030151.75062592
24Base excision repair_Homo sapiens_hsa034101.72222486
25Folate biosynthesis_Homo sapiens_hsa007901.67072825
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.63801354
27Parkinsons disease_Homo sapiens_hsa050121.53659552
28Steroid biosynthesis_Homo sapiens_hsa001001.53412410
29Purine metabolism_Homo sapiens_hsa002301.52984688
30Ribosome_Homo sapiens_hsa030101.46774279
31Huntingtons disease_Homo sapiens_hsa050161.39171897
32Vitamin B6 metabolism_Homo sapiens_hsa007501.38786948
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33357204
34Fatty acid elongation_Homo sapiens_hsa000621.30876088
35Oocyte meiosis_Homo sapiens_hsa041141.27363486
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25347437
37Pyruvate metabolism_Homo sapiens_hsa006201.16459372
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16176434
39Glutathione metabolism_Homo sapiens_hsa004801.15945402
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12047658
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04624452
42Propanoate metabolism_Homo sapiens_hsa006401.01795232
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.95415857
44Alzheimers disease_Homo sapiens_hsa050100.95158786
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93898281
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93149617
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91404860
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91125755
49Butanoate metabolism_Homo sapiens_hsa006500.88913190
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88586721
51Sulfur relay system_Homo sapiens_hsa041220.80962786
52Biosynthesis of amino acids_Homo sapiens_hsa012300.76138386
53Phototransduction_Homo sapiens_hsa047440.74724256
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70931789
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70605052
56Metabolic pathways_Homo sapiens_hsa011000.65889125
57Peroxisome_Homo sapiens_hsa041460.65728656
58Carbon metabolism_Homo sapiens_hsa012000.65424951
59p53 signaling pathway_Homo sapiens_hsa041150.65151081
60TGF-beta signaling pathway_Homo sapiens_hsa043500.64655211
61N-Glycan biosynthesis_Homo sapiens_hsa005100.62001525
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59286490
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58599607
64Cardiac muscle contraction_Homo sapiens_hsa042600.55703620
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49624370
66Fatty acid metabolism_Homo sapiens_hsa012120.48017128
67Regulation of autophagy_Homo sapiens_hsa041400.46910707
68Hippo signaling pathway_Homo sapiens_hsa043900.46863925
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46022845
70Pentose phosphate pathway_Homo sapiens_hsa000300.44740585
71Circadian rhythm_Homo sapiens_hsa047100.43260790
72Sulfur metabolism_Homo sapiens_hsa009200.43152425
73Vitamin digestion and absorption_Homo sapiens_hsa049770.41065907
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40101237
75Taste transduction_Homo sapiens_hsa047420.36981258
76Retinol metabolism_Homo sapiens_hsa008300.34860064
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34383175
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33160360
79Fatty acid biosynthesis_Homo sapiens_hsa000610.31834838
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31809422
81MicroRNAs in cancer_Homo sapiens_hsa052060.31708711
82Tight junction_Homo sapiens_hsa045300.30538836
83beta-Alanine metabolism_Homo sapiens_hsa004100.26443119
84Dopaminergic synapse_Homo sapiens_hsa047280.26174122
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26055690
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26004973
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23729391
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.23682942
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23131245
90Wnt signaling pathway_Homo sapiens_hsa043100.23107735
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19549275
92Lysine degradation_Homo sapiens_hsa003100.17602132
93AMPK signaling pathway_Homo sapiens_hsa041520.17599305
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14497701
95Hedgehog signaling pathway_Homo sapiens_hsa043400.13389589
96Arginine and proline metabolism_Homo sapiens_hsa003300.13326495
97Nicotine addiction_Homo sapiens_hsa050330.12501137
98Tryptophan metabolism_Homo sapiens_hsa003800.12235586
99Glucagon signaling pathway_Homo sapiens_hsa049220.11981620
100Insulin secretion_Homo sapiens_hsa049110.11362727

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