ZNF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.40082220
2nuclear pore organization (GO:0006999)6.63809846
3mitotic sister chromatid cohesion (GO:0007064)5.86341214
4pore complex assembly (GO:0046931)5.40408494
5monoubiquitinated protein deubiquitination (GO:0035520)4.69381919
6pre-miRNA processing (GO:0031054)4.55201964
7regulation of RNA export from nucleus (GO:0046831)4.34159746
8cytoplasmic mRNA processing body assembly (GO:0033962)4.25446517
9negative regulation of neurotransmitter secretion (GO:0046929)3.85818345
10regulation of centriole replication (GO:0046599)3.79247226
11phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.76167266
12DNA topological change (GO:0006265)3.56950063
13regulation of nucleobase-containing compound transport (GO:0032239)3.56665623
14non-recombinational repair (GO:0000726)3.48153591
15double-strand break repair via nonhomologous end joining (GO:0006303)3.48153591
16regulation of DNA endoreduplication (GO:0032875)3.36327817
17regulation of NFAT protein import into nucleus (GO:0051532)3.33831666
18regulation of DNA damage checkpoint (GO:2000001)3.31013098
19histone H3-K9 demethylation (GO:0033169)3.30252839
20sister chromatid segregation (GO:0000819)3.27983061
21regulation of Rac protein signal transduction (GO:0035020)3.19242872
22negative regulation of histone methylation (GO:0031061)3.15118795
23peptidyl-lysine trimethylation (GO:0018023)3.06334669
24dosage compensation (GO:0007549)3.04506784
25establishment of nucleus localization (GO:0040023)3.04496481
26sister chromatid cohesion (GO:0007062)3.04100997
27negative regulation of DNA repair (GO:0045738)3.03360015
28NLS-bearing protein import into nucleus (GO:0006607)3.03176494
29DNA unwinding involved in DNA replication (GO:0006268)3.01042256
30histone H2B ubiquitination (GO:0033523)2.99867544
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98084753
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98084753
33positive regulation of mitotic sister chromatid separation (GO:1901970)2.98084753
34histone H3-K36 demethylation (GO:0070544)2.96750525
35cellular protein complex localization (GO:0034629)2.95829596
36Golgi to endosome transport (GO:0006895)2.94767075
37spermatid nucleus differentiation (GO:0007289)2.93195902
38regulation of sister chromatid cohesion (GO:0007063)2.92929952
39regulation of histone H3-K9 methylation (GO:0051570)2.92144572
40negative regulation of neurotransmitter transport (GO:0051589)2.92113562
41negative regulation of DNA recombination (GO:0045910)2.91096627
42nucleus organization (GO:0006997)2.87202829
43gastrulation with mouth forming second (GO:0001702)2.81117855
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80971561
45microtubule anchoring (GO:0034453)2.80135735
46acrosome assembly (GO:0001675)2.80012695
47histone H3-K4 trimethylation (GO:0080182)2.79362783
48neural tube formation (GO:0001841)2.77404126
49regulation of centrosome duplication (GO:0010824)2.75765403
50nuclear envelope disassembly (GO:0051081)2.72803151
51membrane disassembly (GO:0030397)2.72803151
52histone lysine demethylation (GO:0070076)2.72600459
53mitotic nuclear envelope disassembly (GO:0007077)2.72515648
54regulation of mitotic sister chromatid separation (GO:0010965)2.71811469
55regulation of mitotic sister chromatid segregation (GO:0033047)2.71811469
56regulation of sister chromatid segregation (GO:0033045)2.71811469
57mRNA stabilization (GO:0048255)2.70220853
58RNA stabilization (GO:0043489)2.70220853
59regulation of growth hormone secretion (GO:0060123)2.67379716
60DNA duplex unwinding (GO:0032508)2.67084489
61mitotic chromosome condensation (GO:0007076)2.65982846
62regulation of mitotic metaphase/anaphase transition (GO:0030071)2.65920301
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65920301
64positive regulation of RNA splicing (GO:0033120)2.64570192
65protein localization to kinetochore (GO:0034501)2.64379953
66DNA geometric change (GO:0032392)2.63800511
67ectodermal placode formation (GO:0060788)2.63457963
68V(D)J recombination (GO:0033151)2.63351058
69positive regulation of cell cycle checkpoint (GO:1901978)2.63172609
70intra-S DNA damage checkpoint (GO:0031573)2.62161582
71peptidyl-threonine dephosphorylation (GO:0035970)2.62111857
72metaphase plate congression (GO:0051310)2.62006538
73nucleus localization (GO:0051647)2.61630928
74mitotic sister chromatid segregation (GO:0000070)2.61476150
75negative regulation of fibroblast apoptotic process (GO:2000270)2.59847196
76positive regulation of mRNA processing (GO:0050685)2.59845299
77spindle checkpoint (GO:0031577)2.58974109
78DNA double-strand break processing (GO:0000729)2.58191892
79negative regulation of mitotic sister chromatid separation (GO:2000816)2.57731670
80negative regulation of sister chromatid segregation (GO:0033046)2.57731670
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57731670
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.57731670
83negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57731670
84histone demethylation (GO:0016577)2.56495032
85nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56237579
86regulation of chromosome segregation (GO:0051983)2.54632590
87peptidyl-threonine phosphorylation (GO:0018107)2.54592546
88negative regulation of chromosome segregation (GO:0051985)2.54284884
89mitotic spindle checkpoint (GO:0071174)2.53386806
90mitotic G2/M transition checkpoint (GO:0044818)2.53024544
91regulation of centrosome cycle (GO:0046605)2.52881804
92peptidyl-lysine dimethylation (GO:0018027)2.52609445
93protein K11-linked deubiquitination (GO:0035871)2.49485231
94positive regulation of histone H3-K4 methylation (GO:0051571)2.49004338
95regulation of histone H3-K4 methylation (GO:0051569)2.47932912
96regulation of DNA-templated transcription, initiation (GO:2000142)2.47517278
97peptidyl-threonine modification (GO:0018210)2.47481036
98regulation of histone H3-K27 methylation (GO:0061085)2.47021107
99nerve growth factor signaling pathway (GO:0038180)2.46863571
100histone ubiquitination (GO:0016574)2.45630805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.76606033
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.67286101
3KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.27056154
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.06184180
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.84292395
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82688751
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.77829242
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.76503226
9FUS_26573619_Chip-Seq_HEK293_Human2.45661453
10TAF15_26573619_Chip-Seq_HEK293_Human2.38050740
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29451766
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.21034663
13* EWS_26573619_Chip-Seq_HEK293_Human2.16832276
14AR_21909140_ChIP-Seq_LNCAP_Human2.05571543
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02553016
16WT1_19549856_ChIP-ChIP_CCG9911_Human1.98904001
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96176631
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.89815013
19ELK1_19687146_ChIP-ChIP_HELA_Human1.87576560
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85999390
21IGF1R_20145208_ChIP-Seq_DFB_Human1.83922468
22YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81618799
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78245047
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77727971
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68529952
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67518858
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.66174809
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61612218
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61345274
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58266927
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55836494
32TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53823184
33GATA1_22025678_ChIP-Seq_K562_Human1.50904003
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48083786
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.44308471
36* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44199890
37P300_19829295_ChIP-Seq_ESCs_Human1.42748156
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42297846
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.42119814
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41528657
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39326682
42GBX2_23144817_ChIP-Seq_PC3_Human1.37220767
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36668520
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34212390
45SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32991022
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30765222
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29880973
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.29568391
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24823870
50SMAD4_21799915_ChIP-Seq_A2780_Human1.22759918
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22293847
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.21678942
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21259365
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.20387890
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.19298653
56ER_23166858_ChIP-Seq_MCF-7_Human1.18429132
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17906816
58STAT3_23295773_ChIP-Seq_U87_Human1.16099937
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.14972854
60CHD1_26751641_Chip-Seq_LNCaP_Human1.14179823
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.13957930
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.08606104
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08452623
64* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08317955
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08296849
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08118370
67SOX9_26525672_Chip-Seq_HEART_Mouse1.07166389
68CBP_20019798_ChIP-Seq_JUKART_Human1.05471673
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05471673
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05259100
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04472186
72P53_22387025_ChIP-Seq_ESCs_Mouse1.03816112
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03573326
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03392893
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03352774
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03352774
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03167264
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02940701
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02594023
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01001535
81P300_18555785_Chip-Seq_ESCs_Mouse0.99520388
82SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98348150
83OCT4_18555785_Chip-Seq_ESCs_Mouse0.97900117
84POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96058325
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95439097
86NMYC_18555785_Chip-Seq_ESCs_Mouse0.95419243
87TCF4_23295773_ChIP-Seq_U87_Human0.95408955
88SMAD_19615063_ChIP-ChIP_OVARY_Human0.94726551
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94718603
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93656746
91AR_21572438_ChIP-Seq_LNCaP_Human0.93534813
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92131360
93GF1B_26923725_Chip-Seq_HPCs_Mouse0.92055950
94OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91745906
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91233506
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90770614
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.90677680
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90614726
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.90592669
100SOX2_18555785_Chip-Seq_ESCs_Mouse0.90564034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.40932597
2MP0002009_preneoplasia4.84171350
3MP0003890_abnormal_embryonic-extraembry3.54502120
4MP0010094_abnormal_chromosome_stability2.47799658
5MP0000569_abnormal_digit_pigmentation2.41377739
6MP0004957_abnormal_blastocyst_morpholog2.19804075
7MP0003077_abnormal_cell_cycle2.19760541
8MP0003111_abnormal_nucleus_morphology2.08459933
9MP0005187_abnormal_penis_morphology2.05711398
10MP0010352_gastrointestinal_tract_polyps2.02281278
11MP0003787_abnormal_imprinting2.01475072
12MP0008058_abnormal_DNA_repair1.84802345
13MP0005248_abnormal_Harderian_gland1.69400705
14MP0010234_abnormal_vibrissa_follicle1.68686638
15MP0003221_abnormal_cardiomyocyte_apopto1.67419551
16MP0002084_abnormal_developmental_patter1.66986253
17MP0008877_abnormal_DNA_methylation1.62640584
18MP0001672_abnormal_embryogenesis/_devel1.62074336
19MP0005380_embryogenesis_phenotype1.62074336
20MP0010307_abnormal_tumor_latency1.60732922
21MP0001730_embryonic_growth_arrest1.60630779
22MP0003984_embryonic_growth_retardation1.60092878
23MP0002088_abnormal_embryonic_growth/wei1.57491652
24MP0002396_abnormal_hematopoietic_system1.48489030
25MP0003937_abnormal_limbs/digits/tail_de1.47831189
26MP0000350_abnormal_cell_proliferation1.43826985
27MP0001697_abnormal_embryo_size1.43624791
28MP0008007_abnormal_cellular_replicative1.43094670
29MP0003136_yellow_coat_color1.41990589
30MP0003121_genomic_imprinting1.41775836
31MP0002166_altered_tumor_susceptibility1.40561240
32MP0003693_abnormal_embryo_hatching1.39054199
33MP0009703_decreased_birth_body1.38342624
34MP0005408_hypopigmentation1.37651441
35MP0010678_abnormal_skin_adnexa1.37211219
36MP0000778_abnormal_nervous_system1.35770190
37MP0000516_abnormal_urinary_system1.32702953
38MP0005367_renal/urinary_system_phenotyp1.32702953
39MP0001293_anophthalmia1.32272649
40MP0008932_abnormal_embryonic_tissue1.30598170
41MP0002822_catalepsy1.30573702
42MP0003567_abnormal_fetal_cardiomyocyte1.30097339
43MP0003656_abnormal_erythrocyte_physiolo1.29242511
44MP0002086_abnormal_extraembryonic_tissu1.26105924
45MP0009697_abnormal_copulation1.25703661
46MP0004197_abnormal_fetal_growth/weight/1.23130878
47MP0000015_abnormal_ear_pigmentation1.21628672
48MP0002085_abnormal_embryonic_tissue1.19830054
49MP0004264_abnormal_extraembryonic_tissu1.16902328
50MP0000372_irregular_coat_pigmentation1.16739554
51MP0001286_abnormal_eye_development1.16618967
52MP0003943_abnormal_hepatobiliary_system1.14645494
53MP0000537_abnormal_urethra_morphology1.13436540
54MP0009672_abnormal_birth_weight1.12319129
55MP0000383_abnormal_hair_follicle1.12240418
56MP0002638_abnormal_pupillary_reflex1.12145606
57MP0002697_abnormal_eye_size1.11485976
58MP0001529_abnormal_vocalization1.09443409
59MP0000428_abnormal_craniofacial_morphol1.06405696
60MP0005409_darkened_coat_color1.06065296
61MP0003861_abnormal_nervous_system1.05747552
62MP0002080_prenatal_lethality1.01895361
63MP0001188_hyperpigmentation1.01771654
64MP0004808_abnormal_hematopoietic_stem1.01240914
65MP0001984_abnormal_olfaction1.00175386
66MP0003935_abnormal_craniofacial_develop0.99511667
67MP0005220_abnormal_exocrine_pancreas0.99375629
68MP0002909_abnormal_adrenal_gland0.99350030
69MP0002092_abnormal_eye_morphology0.99289319
70MP0005174_abnormal_tail_pigmentation0.98307922
71MP0005075_abnormal_melanosome_morpholog0.96248861
72MP0005076_abnormal_cell_differentiation0.95070595
73MP0008995_early_reproductive_senescence0.94865317
74MP0003690_abnormal_glial_cell0.94453607
75MP0004381_abnormal_hair_follicle0.94134600
76MP0008961_abnormal_basal_metabolism0.93091453
77MP0002006_tumorigenesis0.89301824
78MP0000631_abnormal_neuroendocrine_gland0.89131243
79MP0002095_abnormal_skin_pigmentation0.88938702
80MP0006072_abnormal_retinal_apoptosis0.86068342
81MP0001915_intracranial_hemorrhage0.85435929
82MP0002090_abnormal_vision0.83263969
83MP0003868_abnormal_feces_composition0.82946072
84MP0002233_abnormal_nose_morphology0.82245981
85MP0001346_abnormal_lacrimal_gland0.81367558
86MP0000955_abnormal_spinal_cord0.80993164
87MP0004185_abnormal_adipocyte_glucose0.78985745
88MP0004270_analgesia0.78793885
89MP0005391_vision/eye_phenotype0.78415544
90MP0004811_abnormal_neuron_physiology0.78320229
91MP0000371_diluted_coat_color0.78260898
92MP0000313_abnormal_cell_death0.77476693
93MP0004233_abnormal_muscle_weight0.77365298
94MP0003300_gastrointestinal_ulcer0.75880522
95MP0003122_maternal_imprinting0.75553526
96MP0001177_atelectasis0.73600884
97MP0005253_abnormal_eye_physiology0.73457172
98MP0003632_abnormal_nervous_system0.73379935
99MP0003385_abnormal_body_wall0.73025340
100MP0002081_perinatal_lethality0.70740853

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.33424603
2Thyroid carcinoma (HP:0002890)4.00083331
3Volvulus (HP:0002580)3.96051289
4Cortical dysplasia (HP:0002539)3.80748033
5Medulloblastoma (HP:0002885)3.18141942
6Deep philtrum (HP:0002002)3.10696085
7Hepatoblastoma (HP:0002884)3.07747211
8Curly hair (HP:0002212)2.88032312
9Rhabdomyosarcoma (HP:0002859)2.85045966
10Pheochromocytoma (HP:0002666)2.76512199
11Nephroblastoma (Wilms tumor) (HP:0002667)2.73716194
12Transitional cell carcinoma of the bladder (HP:0006740)2.69315620
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.66772742
14Degeneration of the lateral corticospinal tracts (HP:0002314)2.66772742
15Insidious onset (HP:0003587)2.65267590
16Termporal pattern (HP:0011008)2.65267590
17Cystic hygroma (HP:0000476)2.63392552
18Embryonal renal neoplasm (HP:0011794)2.61122728
19Overlapping toe (HP:0001845)2.56151677
20Abnormal hair whorl (HP:0010721)2.54228144
21Abnormality of chromosome stability (HP:0003220)2.50600122
22Bladder carcinoma (HP:0002862)2.49784698
23Bladder neoplasm (HP:0009725)2.49784698
24Gastrointestinal carcinoma (HP:0002672)2.48397800
25Malignant gastrointestinal tract tumors (HP:0006749)2.48397800
26Chromsome breakage (HP:0040012)2.43086101
27Abnormality of chromosome segregation (HP:0002916)2.41848949
28Subaortic stenosis (HP:0001682)2.39916801
29Abnormality of the left ventricular outflow tract (HP:0011103)2.39916801
30Uterine leiomyosarcoma (HP:0002891)2.39825704
31Leiomyosarcoma (HP:0100243)2.39825704
32Abnormality of the corticospinal tract (HP:0002492)2.38784036
33Acute myeloid leukemia (HP:0004808)2.38509635
34Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.36282531
35Long clavicles (HP:0000890)2.30964958
36Neoplasm of the thyroid gland (HP:0100031)2.28586571
37Biliary tract neoplasm (HP:0100574)2.25962706
38Truncal obesity (HP:0001956)2.22870350
39Drooling (HP:0002307)2.22233328
40Anal stenosis (HP:0002025)2.18372818
41Macroorchidism (HP:0000053)2.15261445
42Abnormal biliary tract morphology (HP:0012440)2.14763748
43Obsessive-compulsive behavior (HP:0000722)2.14524203
44Large earlobe (HP:0009748)2.12027787
45Neoplasm of striated muscle (HP:0009728)2.10268272
46Neuroendocrine neoplasm (HP:0100634)2.10000232
47Excessive salivation (HP:0003781)2.09219241
48Blue irides (HP:0000635)2.07813063
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06392550
50Neoplasm of the small intestine (HP:0100833)2.03574996
51Absent eyebrow (HP:0002223)2.00207188
52Heterotopia (HP:0002282)1.99984824
53Abnormality of the fingertips (HP:0001211)1.98308592
54Low anterior hairline (HP:0000294)1.97807663
55Menstrual irregularities (HP:0000858)1.97764228
56Increased nuchal translucency (HP:0010880)1.97362337
57Asymmetry of the thorax (HP:0001555)1.97199369
58Aqueductal stenosis (HP:0002410)1.95878299
59Sandal gap (HP:0001852)1.95012673
60Neonatal hypoglycemia (HP:0001998)1.94243889
61Cafe-au-lait spot (HP:0000957)1.91969184
62Astrocytoma (HP:0009592)1.90119693
63Abnormality of the astrocytes (HP:0100707)1.90119693
64Submucous cleft hard palate (HP:0000176)1.89615757
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.88711985
66Glioma (HP:0009733)1.84769264
67Septate vagina (HP:0001153)1.84088636
68Pancreatic islet-cell hyperplasia (HP:0004510)1.84048201
69Subacute progressive viral hepatitis (HP:0006572)1.83940518
70Neoplasm of the oral cavity (HP:0100649)1.83748696
71Poor coordination (HP:0002370)1.81296314
72Hamartoma (HP:0010566)1.81129643
73Embryonal neoplasm (HP:0002898)1.78207029
74Limb hypertonia (HP:0002509)1.77559012
75Resting tremor (HP:0002322)1.77302450
76Uterine neoplasm (HP:0010784)1.77093142
77Vertebral arch anomaly (HP:0008438)1.75005879
78Progressive external ophthalmoplegia (HP:0000590)1.71321900
79Intestinal atresia (HP:0011100)1.71062321
80Hypoplastic labia majora (HP:0000059)1.71009178
81Abnormality of the pancreatic islet cells (HP:0006476)1.68501146
82Abnormality of endocrine pancreas physiology (HP:0012093)1.68501146
83Neoplasm of the adrenal cortex (HP:0100641)1.68252406
84Freckling (HP:0001480)1.67736985
85Ovarian neoplasm (HP:0100615)1.67688555
86Colon cancer (HP:0003003)1.65703417
87Hypoglycemic seizures (HP:0002173)1.64717295
88Midline defect of the nose (HP:0004122)1.64199640
89Missing ribs (HP:0000921)1.62522657
90Germ cell neoplasia (HP:0100728)1.60133907
91Thick eyebrow (HP:0000574)1.60065006
92Dysmetric saccades (HP:0000641)1.59702589
93Abnormal auditory evoked potentials (HP:0006958)1.58583770
94Exotropia (HP:0000577)1.58504465
95Cubitus valgus (HP:0002967)1.58149686
96Abnormal lung lobation (HP:0002101)1.57311085
97Ependymoma (HP:0002888)1.56653957
98Impaired vibration sensation in the lower limbs (HP:0002166)1.56641361
99Abnormal pancreas size (HP:0012094)1.55442966
100Hypopigmentation of the fundus (HP:0007894)1.55342324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD43.46405864
2AKT33.05242958
3EIF2AK32.72100902
4SRPK12.48284447
5MAP3K102.30604936
6MAP3K42.11415595
7BRSK22.07426602
8PLK42.05747823
9CDK122.04093963
10MKNK12.03086328
11MKNK22.01864964
12YES11.99742031
13EEF2K1.93456659
14SGK21.80720946
15ACVR1B1.76036569
16FGFR21.66461849
17STK241.64552409
18TTK1.63555311
19EIF2AK11.62937980
20KSR11.61634523
21TAF11.61587801
22PNCK1.58891222
23WEE11.57161517
24CAMK1G1.55322372
25TSSK61.51301758
26TNIK1.42258019
27NLK1.40155068
28MAP3K21.37018088
29DYRK31.36783573
30PASK1.35962219
31CDK61.32146512
32FGFR31.27937428
33STK31.25928696
34BMPR1B1.25075717
35SGK31.21711515
36CAMK1D1.18733233
37CASK1.17463519
38CDC71.13709692
39BCR1.10934724
40SGK4941.09268957
41SGK2231.09268957
42NTRK31.07650264
43TRIM281.05427101
44CAMKK21.03331997
45KSR20.99236374
46PLK30.98606941
47MST40.98210647
48EIF2AK20.96119422
49NEK90.90271722
50RAF10.88222570
51FGFR10.87932279
52ATM0.86816898
53SCYL20.83448832
54RPS6KA40.82553728
55FRK0.80012528
56LATS10.79918628
57PAK30.79136453
58WNK10.75555674
59CHEK10.74358595
60ATR0.73622158
61RPS6KB20.72054782
62STK38L0.72007126
63DYRK1B0.71685209
64PLK20.71070436
65RPS6KB10.70349781
66NEK60.69224962
67MARK30.65344159
68NEK10.64473545
69WNK30.63115515
70STK390.62413448
71EPHA30.61616733
72CAMK40.60497333
73MAPK100.60282553
74SGK10.58949617
75RET0.57103745
76CCNB10.56078125
77UHMK10.55758526
78CDK30.55653379
79DYRK1A0.55315038
80BMPR20.54336837
81DMPK0.53791526
82ALK0.53514782
83CSNK1E0.50456800
84CLK10.50139980
85CDK10.47784838
86CDK20.47463310
87PDGFRB0.47435599
88NTRK20.47035175
89FGR0.47016613
90STK40.46934523
91MELK0.44243450
92PKN20.43835951
93PLK10.42952902
94IRAK10.42574546
95MAP2K40.42386539
96MAPK130.42290685
97TEC0.39672934
98PIM10.39207084
99PRKDC0.38480731
100IRAK20.35833944

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.41750976
2mRNA surveillance pathway_Homo sapiens_hsa030152.33959926
3Cell cycle_Homo sapiens_hsa041102.11891520
4Endometrial cancer_Homo sapiens_hsa052132.09988783
5Circadian rhythm_Homo sapiens_hsa047102.04905769
6Colorectal cancer_Homo sapiens_hsa052102.01952472
7Spliceosome_Homo sapiens_hsa030401.89315262
8RNA transport_Homo sapiens_hsa030131.89220692
9Thyroid cancer_Homo sapiens_hsa052161.85525972
10Prostate cancer_Homo sapiens_hsa052151.82261533
11Chronic myeloid leukemia_Homo sapiens_hsa052201.75504132
12Non-small cell lung cancer_Homo sapiens_hsa052231.72518262
13Adherens junction_Homo sapiens_hsa045201.71259204
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70994510
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67308959
16Inositol phosphate metabolism_Homo sapiens_hsa005621.63929873
17FoxO signaling pathway_Homo sapiens_hsa040681.61026150
18Renal cell carcinoma_Homo sapiens_hsa052111.60896545
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56079088
20Basal transcription factors_Homo sapiens_hsa030221.51342387
21RNA degradation_Homo sapiens_hsa030181.49873381
22MicroRNAs in cancer_Homo sapiens_hsa052061.48100517
23Pancreatic cancer_Homo sapiens_hsa052121.43941832
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40031255
25ErbB signaling pathway_Homo sapiens_hsa040121.39319546
26mTOR signaling pathway_Homo sapiens_hsa041501.37736149
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37532391
28Propanoate metabolism_Homo sapiens_hsa006401.36493075
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35967918
30Lysine degradation_Homo sapiens_hsa003101.34276218
31Prolactin signaling pathway_Homo sapiens_hsa049171.31554588
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30298613
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28879403
34Glioma_Homo sapiens_hsa052141.27997816
35TGF-beta signaling pathway_Homo sapiens_hsa043501.27257163
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26584454
37Fanconi anemia pathway_Homo sapiens_hsa034601.20225061
38Protein export_Homo sapiens_hsa030601.18985584
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18585529
40Mismatch repair_Homo sapiens_hsa034301.16886103
41Oocyte meiosis_Homo sapiens_hsa041141.14079324
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12788122
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07369135
44Viral carcinogenesis_Homo sapiens_hsa052031.05913587
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.04810742
46Dorso-ventral axis formation_Homo sapiens_hsa043201.03426239
47Regulation of autophagy_Homo sapiens_hsa041401.01035219
48Type II diabetes mellitus_Homo sapiens_hsa049301.00321212
49Choline metabolism in cancer_Homo sapiens_hsa052310.98821019
50Hepatitis B_Homo sapiens_hsa051610.98287238
51Long-term potentiation_Homo sapiens_hsa047200.94104218
52B cell receptor signaling pathway_Homo sapiens_hsa046620.94088539
53Hippo signaling pathway_Homo sapiens_hsa043900.91043584
54Wnt signaling pathway_Homo sapiens_hsa043100.90979036
55Steroid biosynthesis_Homo sapiens_hsa001000.88821774
56AMPK signaling pathway_Homo sapiens_hsa041520.87095931
57T cell receptor signaling pathway_Homo sapiens_hsa046600.85097400
58Nucleotide excision repair_Homo sapiens_hsa034200.84670392
59Insulin signaling pathway_Homo sapiens_hsa049100.82911230
60Acute myeloid leukemia_Homo sapiens_hsa052210.79573583
61Measles_Homo sapiens_hsa051620.77728034
62Alcoholism_Homo sapiens_hsa050340.77610026
63Hedgehog signaling pathway_Homo sapiens_hsa043400.75445408
64Long-term depression_Homo sapiens_hsa047300.75163342
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72666639
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.70829919
67Estrogen signaling pathway_Homo sapiens_hsa049150.70637363
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70250456
69p53 signaling pathway_Homo sapiens_hsa041150.69605529
70Selenocompound metabolism_Homo sapiens_hsa004500.68791432
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68417148
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67408193
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66011104
74Tight junction_Homo sapiens_hsa045300.64583363
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63520916
76Small cell lung cancer_Homo sapiens_hsa052220.63081334
77Melanoma_Homo sapiens_hsa052180.61361105
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61100671
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60095353
80Fatty acid metabolism_Homo sapiens_hsa012120.59519577
81Hepatitis C_Homo sapiens_hsa051600.59012132
82Basal cell carcinoma_Homo sapiens_hsa052170.56802380
83Butanoate metabolism_Homo sapiens_hsa006500.56334945
84Gap junction_Homo sapiens_hsa045400.56229814
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.56178594
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54883308
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52218588
88Melanogenesis_Homo sapiens_hsa049160.50721495
89Herpes simplex infection_Homo sapiens_hsa051680.50436406
90HIF-1 signaling pathway_Homo sapiens_hsa040660.50066122
91Pathways in cancer_Homo sapiens_hsa052000.50005403
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.48967995
93Insulin resistance_Homo sapiens_hsa049310.47492409
94Amphetamine addiction_Homo sapiens_hsa050310.47031399
95Proteoglycans in cancer_Homo sapiens_hsa052050.46050677
96One carbon pool by folate_Homo sapiens_hsa006700.45033851
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.44807214
98Notch signaling pathway_Homo sapiens_hsa043300.44739515
99DNA replication_Homo sapiens_hsa030300.43781511
100Dopaminergic synapse_Homo sapiens_hsa047280.43327815

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