ZNF248

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.62183435
2presynaptic membrane organization (GO:0097090)4.56111616
3axonal fasciculation (GO:0007413)4.48429524
4neuron cell-cell adhesion (GO:0007158)4.29537091
5gamma-aminobutyric acid transport (GO:0015812)4.18462197
6protein localization to synapse (GO:0035418)4.15771519
7presynaptic membrane assembly (GO:0097105)4.11693300
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.10369165
9synaptic vesicle maturation (GO:0016188)4.08671505
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02295929
11neuron recognition (GO:0008038)3.93166191
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90019623
13vocalization behavior (GO:0071625)3.85669510
14synaptic transmission, glutamatergic (GO:0035249)3.83231108
15nucleobase catabolic process (GO:0046113)3.82606474
16synapse assembly (GO:0007416)3.70089126
17neurotransmitter-gated ion channel clustering (GO:0072578)3.65458645
18positive regulation of mitochondrial fission (GO:0090141)3.61812571
19establishment of mitochondrion localization (GO:0051654)3.61363739
20neuronal action potential propagation (GO:0019227)3.58163774
21postsynaptic membrane organization (GO:0001941)3.55285365
22glutamate receptor signaling pathway (GO:0007215)3.54683146
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47972081
24auditory behavior (GO:0031223)3.40635545
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40474540
26neuron-neuron synaptic transmission (GO:0007270)3.37132987
27mechanosensory behavior (GO:0007638)3.28701823
28cell migration in hindbrain (GO:0021535)3.26011816
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25916870
30synaptic vesicle exocytosis (GO:0016079)3.23741791
31negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17341001
32positive regulation of dendritic spine morphogenesis (GO:0061003)3.17045721
33negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15902716
34behavioral response to nicotine (GO:0035095)3.14054929
35dendritic spine morphogenesis (GO:0060997)3.13984272
36central nervous system projection neuron axonogenesis (GO:0021952)3.12466765
37neurotransmitter secretion (GO:0007269)3.11937904
38transmission of nerve impulse (GO:0019226)3.09079094
39calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.08623725
40glycosphingolipid biosynthetic process (GO:0006688)3.03004386
41regulation of synaptic vesicle exocytosis (GO:2000300)3.01076756
42adult walking behavior (GO:0007628)3.00919386
43glutamate secretion (GO:0014047)3.00836554
44membrane depolarization during action potential (GO:0086010)2.99056760
45C4-dicarboxylate transport (GO:0015740)2.97578603
46neuronal ion channel clustering (GO:0045161)2.95726145
47positive regulation of synapse assembly (GO:0051965)2.95471596
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93927869
49neuromuscular synaptic transmission (GO:0007274)2.93172646
50mitochondrion transport along microtubule (GO:0047497)2.91877801
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.91877801
52regulation of synaptic vesicle transport (GO:1902803)2.90111728
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89722603
54dendrite morphogenesis (GO:0048813)2.87533138
55retinal ganglion cell axon guidance (GO:0031290)2.87407434
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.86934499
57regulation of dendritic spine morphogenesis (GO:0061001)2.82903690
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80756289
59regulation of synapse structural plasticity (GO:0051823)2.79915756
60substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79636064
61substrate-independent telencephalic tangential migration (GO:0021826)2.79636064
62synapse organization (GO:0050808)2.79531325
63central nervous system neuron axonogenesis (GO:0021955)2.78952989
64regulation of glutamate receptor signaling pathway (GO:1900449)2.71575264
65mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.69863000
66positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.69863000
67neuronal action potential (GO:0019228)2.68861684
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68226651
69short-term memory (GO:0007614)2.65720140
70central nervous system myelination (GO:0022010)2.65139454
71axon ensheathment in central nervous system (GO:0032291)2.65139454
72nonmotile primary cilium assembly (GO:0035058)2.63612646
73response to auditory stimulus (GO:0010996)2.62471570
74regulation of feeding behavior (GO:0060259)2.61725229
75phenol-containing compound catabolic process (GO:0019336)2.57735685
76regulation of synaptic transmission, glutamatergic (GO:0051966)2.57576552
77synaptic vesicle docking involved in exocytosis (GO:0016081)2.56456548
78protein polyglutamylation (GO:0018095)2.54416838
79regulation of neurotransmitter levels (GO:0001505)2.53927476
80cerebellar Purkinje cell differentiation (GO:0021702)2.53489874
81positive regulation of synapse maturation (GO:0090129)2.52424182
82behavioral fear response (GO:0001662)2.51125366
83behavioral defense response (GO:0002209)2.51125366
84intraciliary transport (GO:0042073)2.48998178
85spinal cord development (GO:0021510)2.47668370
86organelle transport along microtubule (GO:0072384)2.46928101
87cerebral cortex radially oriented cell migration (GO:0021799)2.45590044
88neurotransmitter transport (GO:0006836)2.45245291
89dendrite development (GO:0016358)2.45119232
90gamma-aminobutyric acid signaling pathway (GO:0007214)2.44635689
91layer formation in cerebral cortex (GO:0021819)2.44575393
92synaptic transmission (GO:0007268)2.43722029
93ganglion development (GO:0061548)2.43057872
94adult behavior (GO:0030534)2.42598022
95behavioral response to ethanol (GO:0048149)2.41839218
96synaptic vesicle endocytosis (GO:0048488)2.41607893
97axonogenesis (GO:0007409)2.41580649
98regulation of synapse assembly (GO:0051963)2.41039073
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40900579
100positive regulation of amino acid transport (GO:0051957)2.40156465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.81211029
2GBX2_23144817_ChIP-Seq_PC3_Human3.77029791
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.08275148
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74296451
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.71400125
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61760445
7TAF15_26573619_Chip-Seq_HEK293_Human2.59623183
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55906202
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.47451278
10IGF1R_20145208_ChIP-Seq_DFB_Human2.44786233
11* ZNF274_21170338_ChIP-Seq_K562_Hela2.40926166
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24260579
13VDR_22108803_ChIP-Seq_LS180_Human2.22978272
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15736838
15FUS_26573619_Chip-Seq_HEK293_Human2.08827210
16REST_21632747_ChIP-Seq_MESCs_Mouse2.08017124
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05997809
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03016997
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97907693
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.97103905
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92805671
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92364127
23P300_19829295_ChIP-Seq_ESCs_Human1.91903509
24SMAD4_21799915_ChIP-Seq_A2780_Human1.88999248
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88334848
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87417854
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86917891
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86128627
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.85411392
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84565581
31RNF2_27304074_Chip-Seq_NSC_Mouse1.79336286
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.75405151
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72003151
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71767038
35EWS_26573619_Chip-Seq_HEK293_Human1.70091800
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.67397646
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65741594
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.64897685
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62697801
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61220054
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61015814
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59332792
43AR_21572438_ChIP-Seq_LNCaP_Human1.57426332
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54939842
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.54701439
46STAT3_23295773_ChIP-Seq_U87_Human1.52490711
47AR_25329375_ChIP-Seq_VCAP_Human1.49145626
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48214938
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46646415
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46633982
51ER_23166858_ChIP-Seq_MCF-7_Human1.46248489
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.43880210
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43617799
54TCF4_23295773_ChIP-Seq_U87_Human1.40552825
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38121067
56CBP_20019798_ChIP-Seq_JUKART_Human1.36956076
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36956076
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36804507
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35489851
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34878371
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34878371
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33791104
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30458724
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.29456788
65RUNX2_22187159_ChIP-Seq_PCA_Human1.29242625
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24987454
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.21379690
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21123493
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20716475
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20707910
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20550852
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20550852
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.19302923
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19114003
75IRF1_19129219_ChIP-ChIP_H3396_Human1.18696407
76DROSHA_22980978_ChIP-Seq_HELA_Human1.18378159
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18002871
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16079874
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.16004894
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13187328
81BCAT_22108803_ChIP-Seq_LS180_Human1.11748469
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.10888544
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10495298
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09500640
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.09387083
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.08996303
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08819669
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08557931
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07909438
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06715108
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05654289
92P53_22387025_ChIP-Seq_ESCs_Mouse1.05025312
93TCF4_22108803_ChIP-Seq_LS180_Human1.03307014
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02566392
95AR_19668381_ChIP-Seq_PC3_Human1.02465010
96JUN_21703547_ChIP-Seq_K562_Human1.01780083
97SOX9_26525672_Chip-Seq_HEART_Mouse1.01482191
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00935774
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99136844
100KDM2B_26808549_Chip-Seq_REH_Human0.97811859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.92845206
2MP0004859_abnormal_synaptic_plasticity3.51038806
3MP0003787_abnormal_imprinting3.29089893
4MP0004270_analgesia2.96930484
5MP0002822_catalepsy2.80701085
6MP0003635_abnormal_synaptic_transmissio2.58977210
7MP0005423_abnormal_somatic_nervous2.57827544
8MP0002735_abnormal_chemical_nociception2.50632477
9MP0001968_abnormal_touch/_nociception2.50513815
10MP0003122_maternal_imprinting2.47469728
11MP0009046_muscle_twitch2.38575143
12MP0000778_abnormal_nervous_system2.37313805
13MP0009745_abnormal_behavioral_response2.26735704
14MP0002272_abnormal_nervous_system2.25943990
15MP0001486_abnormal_startle_reflex2.21413491
16MP0003121_genomic_imprinting2.17096230
17MP0008877_abnormal_DNA_methylation2.16831991
18MP0002063_abnormal_learning/memory/cond2.14802158
19MP0002734_abnormal_mechanical_nocicepti2.04856637
20MP0002064_seizures2.02793608
21MP0002572_abnormal_emotion/affect_behav1.94826134
22MP0001984_abnormal_olfaction1.93883001
23MP0006276_abnormal_autonomic_nervous1.91165265
24MP0006292_abnormal_olfactory_placode1.83717402
25MP0002736_abnormal_nociception_after1.82078130
26MP0001529_abnormal_vocalization1.78300071
27MP0002733_abnormal_thermal_nociception1.71302501
28MP0002067_abnormal_sensory_capabilities1.69894497
29MP0002837_dystrophic_cardiac_calcinosis1.69814456
30MP0002557_abnormal_social/conspecific_i1.66495681
31MP0002184_abnormal_innervation1.65526358
32MP0001970_abnormal_pain_threshold1.65257192
33MP0000955_abnormal_spinal_cord1.60644054
34MP0004885_abnormal_endolymph1.59260026
35MP0005645_abnormal_hypothalamus_physiol1.52950048
36MP0000569_abnormal_digit_pigmentation1.52552213
37MP0005187_abnormal_penis_morphology1.50116803
38MP0005646_abnormal_pituitary_gland1.48762226
39MP0005394_taste/olfaction_phenotype1.47169484
40MP0005499_abnormal_olfactory_system1.47169484
41MP0002638_abnormal_pupillary_reflex1.45489862
42MP0002102_abnormal_ear_morphology1.43716702
43MP0004811_abnormal_neuron_physiology1.43397661
44MP0002653_abnormal_ependyma_morphology1.42624562
45MP0004924_abnormal_behavior1.41454006
46MP0005386_behavior/neurological_phenoty1.41454006
47MP0001986_abnormal_taste_sensitivity1.41425409
48MP0005551_abnormal_eye_electrophysiolog1.41183261
49MP0004142_abnormal_muscle_tone1.40458097
50MP0001502_abnormal_circadian_rhythm1.40290645
51MP0004145_abnormal_muscle_electrophysio1.39918922
52MP0002882_abnormal_neuron_morphology1.35357203
53MP0008789_abnormal_olfactory_epithelium1.29750015
54MP0000631_abnormal_neuroendocrine_gland1.26492407
55MP0002909_abnormal_adrenal_gland1.26401549
56MP0001188_hyperpigmentation1.25831814
57MP0004133_heterotaxia1.16829466
58MP0001440_abnormal_grooming_behavior1.16530755
59MP0006072_abnormal_retinal_apoptosis1.15409519
60MP0002152_abnormal_brain_morphology1.11470923
61MP0002752_abnormal_somatic_nervous1.11170276
62MP0005253_abnormal_eye_physiology1.10973267
63MP0003633_abnormal_nervous_system1.09597097
64MP0002066_abnormal_motor_capabilities/c1.09528319
65MP0001501_abnormal_sleep_pattern1.08111295
66MP0002234_abnormal_pharynx_morphology1.05704324
67MP0004742_abnormal_vestibular_system1.04932553
68MP0004215_abnormal_myocardial_fiber1.03925155
69MP0002751_abnormal_autonomic_nervous1.03583797
70MP0008569_lethality_at_weaning1.01450790
71MP0001485_abnormal_pinna_reflex1.00673398
72MP0004043_abnormal_pH_regulation0.97559100
73MP0009780_abnormal_chondrocyte_physiolo0.95883912
74MP0000013_abnormal_adipose_tissue0.93320228
75MP0000049_abnormal_middle_ear0.89388036
76MP0003861_abnormal_nervous_system0.88567993
77MP0002229_neurodegeneration0.87943032
78MP0001299_abnormal_eye_distance/0.86888964
79MP0001963_abnormal_hearing_physiology0.85481111
80MP0003631_nervous_system_phenotype0.85424773
81MP0002069_abnormal_eating/drinking_beha0.82186123
82MP0005195_abnormal_posterior_eye0.78962842
83MP0003123_paternal_imprinting0.78393512
84MP0003567_abnormal_fetal_cardiomyocyte0.78219765
85MP0000026_abnormal_inner_ear0.77859650
86MP0002160_abnormal_reproductive_system0.77645813
87MP0002233_abnormal_nose_morphology0.77146004
88MP0001905_abnormal_dopamine_level0.75877424
89MP0008872_abnormal_physiological_respon0.72223701
90MP0005084_abnormal_gallbladder_morpholo0.70291543
91MP0002928_abnormal_bile_duct0.69504000
92MP0010386_abnormal_urinary_bladder0.69366304
93MP0003385_abnormal_body_wall0.68992783
94MP0003890_abnormal_embryonic-extraembry0.68709968
95MP0003119_abnormal_digestive_system0.66740562
96MP0003938_abnormal_ear_development0.66425702
97MP0000427_abnormal_hair_cycle0.66416337
98MP0004085_abnormal_heartbeat0.65501249
99MP0003698_abnormal_male_reproductive0.62943657
100MP0003195_calcinosis0.62144563

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.98265813
2Focal seizures (HP:0007359)3.80689676
3Hyperventilation (HP:0002883)3.78345129
4Febrile seizures (HP:0002373)3.54727417
5Myokymia (HP:0002411)3.48029498
6Medial flaring of the eyebrow (HP:0010747)3.42017057
7Gait imbalance (HP:0002141)3.31331528
8Drooling (HP:0002307)3.29581983
9Epileptic encephalopathy (HP:0200134)3.27195888
10Progressive cerebellar ataxia (HP:0002073)3.11876584
11Atonic seizures (HP:0010819)3.05757444
12Limb dystonia (HP:0002451)3.03898152
13Excessive salivation (HP:0003781)2.99006634
14Congenital primary aphakia (HP:0007707)2.96932280
15Molar tooth sign on MRI (HP:0002419)2.85238672
16Abnormality of midbrain morphology (HP:0002418)2.85238672
17Broad-based gait (HP:0002136)2.80636238
18Pancreatic cysts (HP:0001737)2.80245775
19Pancreatic fibrosis (HP:0100732)2.77223566
20Nephrogenic diabetes insipidus (HP:0009806)2.73696969
21Epileptiform EEG discharges (HP:0011182)2.73569734
22True hermaphroditism (HP:0010459)2.72610356
23Absent speech (HP:0001344)2.71329714
24EEG with generalized epileptiform discharges (HP:0011198)2.70227797
25Gaze-evoked nystagmus (HP:0000640)2.68218237
26Hypsarrhythmia (HP:0002521)2.63995077
27Abnormality of the labia minora (HP:0012880)2.62132620
28Genital tract atresia (HP:0001827)2.61103636
29Hemiparesis (HP:0001269)2.59477929
30Nephronophthisis (HP:0000090)2.56006143
31Vaginal atresia (HP:0000148)2.53338506
32Dialeptic seizures (HP:0011146)2.52586044
33Polyphagia (HP:0002591)2.51259862
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.44588618
35Lissencephaly (HP:0001339)2.40611046
36Pachygyria (HP:0001302)2.39356297
37Specific learning disability (HP:0001328)2.38488297
38Generalized tonic-clonic seizures (HP:0002069)2.38290138
39Hepatoblastoma (HP:0002884)2.35033912
40Retinal dysplasia (HP:0007973)2.32141723
41Absence seizures (HP:0002121)2.31937946
42Inability to walk (HP:0002540)2.30708798
43Hypothermia (HP:0002045)2.30603810
44Agitation (HP:0000713)2.28963653
45Genetic anticipation (HP:0003743)2.20355359
46Abnormality of the corticospinal tract (HP:0002492)2.19513592
47Abnormality of the renal medulla (HP:0100957)2.15720688
48Protruding tongue (HP:0010808)2.15162404
49Amblyopia (HP:0000646)2.14903793
50Poor coordination (HP:0002370)2.14660472
51Thyroid-stimulating hormone excess (HP:0002925)2.14043847
52Action tremor (HP:0002345)2.13384113
53Colon cancer (HP:0003003)2.11416018
54Progressive inability to walk (HP:0002505)2.10501999
55Amyotrophic lateral sclerosis (HP:0007354)2.09241119
56Postaxial hand polydactyly (HP:0001162)2.07062438
57Short tibia (HP:0005736)2.06668314
58Hypoplasia of the brainstem (HP:0002365)2.06574609
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06574609
60Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03438730
61Spastic tetraplegia (HP:0002510)2.02064485
62Narrow forehead (HP:0000341)1.97712437
63Spastic gait (HP:0002064)1.94679764
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94550114
65Degeneration of the lateral corticospinal tracts (HP:0002314)1.94550114
66Papillary thyroid carcinoma (HP:0002895)1.92436060
67Failure to thrive in infancy (HP:0001531)1.91655836
68Poor eye contact (HP:0000817)1.91257560
69Intestinal atresia (HP:0011100)1.90709575
70Urinary urgency (HP:0000012)1.89494139
71Type II lissencephaly (HP:0007260)1.89492305
72Impaired vibration sensation in the lower limbs (HP:0002166)1.89252804
73Exotropia (HP:0000577)1.89179008
74Decreased testicular size (HP:0008734)1.86923045
75Volvulus (HP:0002580)1.84853045
76Sclerocornea (HP:0000647)1.84522660
77Hypoplasia of the corpus callosum (HP:0002079)1.84427630
78Abnormal eating behavior (HP:0100738)1.83785875
79Status epilepticus (HP:0002133)1.82901686
80Micropenis (HP:0000054)1.81649457
81Abnormal hair whorl (HP:0010721)1.81067514
82Short foot (HP:0001773)1.79386631
83Urinary bladder sphincter dysfunction (HP:0002839)1.76422454
84Optic nerve hypoplasia (HP:0000609)1.76366411
85Prominent nasal bridge (HP:0000426)1.76009664
86Intellectual disability, severe (HP:0010864)1.75185383
87Generalized myoclonic seizures (HP:0002123)1.74934667
88Cystic liver disease (HP:0006706)1.73237551
89Morphological abnormality of the pyramidal tract (HP:0002062)1.71615164
90Bifid tongue (HP:0010297)1.71566308
91Tented upper lip vermilion (HP:0010804)1.70677152
92Abnormality of the pubic bones (HP:0003172)1.69714243
93Scrotal hypoplasia (HP:0000046)1.69520578
94Dysdiadochokinesis (HP:0002075)1.69378666
95Cortical dysplasia (HP:0002539)1.68551497
96Chronic hepatic failure (HP:0100626)1.68234946
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.67983565
98Intention tremor (HP:0002080)1.64286674
99Esotropia (HP:0000565)1.63003914
100Polymicrogyria (HP:0002126)1.61920134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.17680978
2MARK14.11240637
3CASK3.58231171
4MAP2K73.03826403
5EPHA42.93287347
6MAPK132.91269118
7PINK12.55754939
8WNK32.43372039
9FRK2.42480106
10BCR2.41163982
11NTRK32.22734754
12MAP4K22.13550435
13MAP2K42.00909803
14NTRK21.91255395
15BMPR1B1.75912119
16ERBB31.65977788
17EPHA31.64311463
18TNIK1.58088666
19CSNK1G21.47123696
20PRKCG1.44950639
21MINK11.43396829
22DYRK21.43149944
23PAK31.36505023
24SIK21.30048994
25DAPK21.28390049
26CSNK1A1L1.24988986
27CSNK1G31.23886305
28MAP3K61.23827584
29CDK191.16076158
30CAMKK21.11842565
31PHKG11.10286986
32PHKG21.10286986
33PLK21.09308347
34STK161.08522605
35CSNK1G11.08072051
36TAOK31.06672518
37UHMK11.04174139
38PKN11.01694923
39DYRK1A1.01623491
40STK38L1.00989520
41CDK51.00259941
42PRKCE0.98396877
43PAK60.97133671
44CDK30.95778045
45RPS6KA40.93948117
46DYRK30.93196554
47SGK2230.92507025
48SGK4940.92507025
49TRIM280.90298758
50INSRR0.89345145
51WNK40.88452156
52CAMK2A0.86283186
53PNCK0.84047160
54AKT30.82995245
55SGK20.81802500
56OBSCN0.81186437
57CAMK10.79814871
58BRD40.79478264
59MKNK20.78797082
60CAMK2B0.77930248
61BCKDK0.77887282
62FGFR20.77211082
63OXSR10.72942738
64STK390.70977519
65PRKCZ0.67045805
66PIK3CA0.61542146
67PRKD30.60043620
68CAMK40.59820167
69GRK10.59469265
70NTRK10.59229261
71ADRBK20.58982579
72CAMKK10.58806331
73CCNB10.57549792
74CAMK2G0.55147146
75CSNK1A10.55073047
76PRKACA0.52785836
77PRKAA10.51970913
78SRPK10.51656481
79DYRK1B0.50067446
80CSNK1D0.49475102
81CDK140.49163602
82NUAK10.49034489
83CSNK1E0.48400718
84MKNK10.46565320
85CDK180.46471934
86CAMK2D0.45489069
87ERBB20.45110666
88PRKACB0.44838639
89ADRBK10.44783757
90SGK10.44164769
91RET0.43422741
92CDK11A0.42996363
93MAP3K50.42665476
94CDK150.41969600
95CDK80.41405969
96ZAK0.40490018
97PRKG10.40399043
98STK380.40394626
99RPS6KA30.40206765
100GRK70.39796985

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.75636589
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90697976
3GABAergic synapse_Homo sapiens_hsa047272.73113141
4Glutamatergic synapse_Homo sapiens_hsa047242.65270114
5Circadian entrainment_Homo sapiens_hsa047132.55273648
6Morphine addiction_Homo sapiens_hsa050322.37328059
7Dopaminergic synapse_Homo sapiens_hsa047282.28538283
8Amphetamine addiction_Homo sapiens_hsa050312.27682671
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20088121
10Synaptic vesicle cycle_Homo sapiens_hsa047212.12879653
11Cocaine addiction_Homo sapiens_hsa050302.10382251
12Insulin secretion_Homo sapiens_hsa049111.99124312
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98851597
14Taste transduction_Homo sapiens_hsa047421.95256287
15Phototransduction_Homo sapiens_hsa047441.88912905
16Butanoate metabolism_Homo sapiens_hsa006501.75194276
17Long-term depression_Homo sapiens_hsa047301.72710554
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67283242
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56189261
20Cholinergic synapse_Homo sapiens_hsa047251.50395786
21Serotonergic synapse_Homo sapiens_hsa047261.44203082
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42650988
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41280276
24Renin secretion_Homo sapiens_hsa049241.39632357
25Salivary secretion_Homo sapiens_hsa049701.38471525
26Axon guidance_Homo sapiens_hsa043601.37114219
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36311797
28Cardiac muscle contraction_Homo sapiens_hsa042601.34025762
29Olfactory transduction_Homo sapiens_hsa047401.32454388
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31949719
31Type II diabetes mellitus_Homo sapiens_hsa049301.23780799
32Propanoate metabolism_Homo sapiens_hsa006401.21112640
33Long-term potentiation_Homo sapiens_hsa047201.19482668
34Circadian rhythm_Homo sapiens_hsa047101.18618355
35Calcium signaling pathway_Homo sapiens_hsa040201.14406951
36Oxytocin signaling pathway_Homo sapiens_hsa049211.09948026
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06787873
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05925309
39cAMP signaling pathway_Homo sapiens_hsa040241.03203807
40Regulation of autophagy_Homo sapiens_hsa041401.01976061
41Gap junction_Homo sapiens_hsa045400.97167391
42Gastric acid secretion_Homo sapiens_hsa049710.96172993
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91294888
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86486646
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84272139
46Basal transcription factors_Homo sapiens_hsa030220.82312802
47Ether lipid metabolism_Homo sapiens_hsa005650.81598691
48Protein export_Homo sapiens_hsa030600.75010085
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74451198
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.73007882
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72933930
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72571422
53Oocyte meiosis_Homo sapiens_hsa041140.72114419
54Parkinsons disease_Homo sapiens_hsa050120.71136070
55Nitrogen metabolism_Homo sapiens_hsa009100.68243828
56Oxidative phosphorylation_Homo sapiens_hsa001900.66518361
57Collecting duct acid secretion_Homo sapiens_hsa049660.66095396
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65566625
59Alcoholism_Homo sapiens_hsa050340.65281870
60Dorso-ventral axis formation_Homo sapiens_hsa043200.62630540
61Glucagon signaling pathway_Homo sapiens_hsa049220.57559555
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55892955
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55628621
64Alzheimers disease_Homo sapiens_hsa050100.54297949
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54025061
66Dilated cardiomyopathy_Homo sapiens_hsa054140.53078688
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52220433
68Peroxisome_Homo sapiens_hsa041460.51954489
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50924422
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50677685
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50625047
72Linoleic acid metabolism_Homo sapiens_hsa005910.50118066
73Lysine degradation_Homo sapiens_hsa003100.48658923
74Hedgehog signaling pathway_Homo sapiens_hsa043400.47920202
75Tryptophan metabolism_Homo sapiens_hsa003800.47645568
76AMPK signaling pathway_Homo sapiens_hsa041520.47586922
77Hippo signaling pathway_Homo sapiens_hsa043900.47278049
78Ras signaling pathway_Homo sapiens_hsa040140.47191720
79Thyroid hormone synthesis_Homo sapiens_hsa049180.46487097
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45758318
81ABC transporters_Homo sapiens_hsa020100.44779757
82beta-Alanine metabolism_Homo sapiens_hsa004100.44156818
83Estrogen signaling pathway_Homo sapiens_hsa049150.43858558
84Melanogenesis_Homo sapiens_hsa049160.42434125
85Fatty acid metabolism_Homo sapiens_hsa012120.41901262
86GnRH signaling pathway_Homo sapiens_hsa049120.41313772
87Fanconi anemia pathway_Homo sapiens_hsa034600.40857294
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.40798243
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39600734
90Pancreatic secretion_Homo sapiens_hsa049720.38830960
91Wnt signaling pathway_Homo sapiens_hsa043100.38798219
92Huntingtons disease_Homo sapiens_hsa050160.37588765
93Ovarian steroidogenesis_Homo sapiens_hsa049130.36500950
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36253639
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35827118
96MAPK signaling pathway_Homo sapiens_hsa040100.34897003
97Arginine and proline metabolism_Homo sapiens_hsa003300.34553058
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34480675
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32466162
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30990546

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