ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.70909706
2	fucose catabolic process (GO:0019317)	4.69517877
3	L-fucose metabolic process (GO:0042354)	4.69517877
4	L-fucose catabolic process (GO:0042355)	4.69517877
5	behavioral response to nicotine (GO:0035095)	4.51150445
6	pyrimidine nucleobase catabolic process (GO:0006208)	4.31218730
7	presynaptic membrane assembly (GO:0097105)	3.85088179
8	neuron cell-cell adhesion (GO:0007158)	3.74130060
9	DNA deamination (GO:0045006)	3.69600069
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.66528359
11	auditory behavior (GO:0031223)	3.61563695
12	nucleobase catabolic process (GO:0046113)	3.59853189
13	neuronal action potential propagation (GO:0019227)	3.55816579
14	presynaptic membrane organization (GO:0097090)	3.49539354
15	nonmotile primary cilium assembly (GO:0035058)	3.48012284
16	postsynaptic membrane organization (GO:0001941)	3.47114387
17	neurotransmitter-gated ion channel clustering (GO:0072578)	3.45158905
18	neural tube formation (GO:0001841)	3.36078802
19	negative regulation of mast cell activation (GO:0033004)	3.33675546
20	limb bud formation (GO:0060174)	3.24542920
21	vocalization behavior (GO:0071625)	3.22502997
22	platelet dense granule organization (GO:0060155)	3.17410276
23	mechanosensory behavior (GO:0007638)	3.14393545
24	inner ear receptor stereocilium organization (GO:0060122)	3.10040672
25	startle response (GO:0001964)	3.06007737
26	indolalkylamine metabolic process (GO:0006586)	3.05769910
27	retinal ganglion cell axon guidance (GO:0031290)	3.01903639
28	indole-containing compound catabolic process (GO:0042436)	2.96527682
29	indolalkylamine catabolic process (GO:0046218)	2.96527682
30	tryptophan catabolic process (GO:0006569)	2.96527682
31	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.95232611
32	gamma-aminobutyric acid transport (GO:0015812)	2.94802241
33	negative regulation of telomere maintenance (GO:0032205)	2.92843665
34	behavioral response to ethanol (GO:0048149)	2.92018652
35	replication fork processing (GO:0031297)	2.90493414
36	detection of light stimulus involved in sensory perception (GO:0050962)	2.89445559
37	detection of light stimulus involved in visual perception (GO:0050908)	2.89445559
38	retinal cone cell development (GO:0046549)	2.88949596
39	protein neddylation (GO:0045116)	2.88800065
40	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.87812038
41	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.87812038
42	regulation of translation, ncRNA-mediated (GO:0045974)	2.87812038
43	regulation of collateral sprouting (GO:0048670)	2.87348207
44	cilium morphogenesis (GO:0060271)	2.86068983
45	sulfation (GO:0051923)	2.83864188
46	dendritic spine morphogenesis (GO:0060997)	2.82011623
47	synapse assembly (GO:0007416)	2.79161463
48	regulation of cilium movement (GO:0003352)	2.78385262
49	epithelial cilium movement (GO:0003351)	2.77657226
50	cornea development in camera-type eye (GO:0061303)	2.76633606
51	kynurenine metabolic process (GO:0070189)	2.76543435
52	DNA double-strand break processing (GO:0000729)	2.75115205
53	water-soluble vitamin biosynthetic process (GO:0042364)	2.73292180
54	protein-cofactor linkage (GO:0018065)	2.73259919
55	regulation of action potential (GO:0098900)	2.72148728
56	regulation of meiosis I (GO:0060631)	2.72087043
57	piRNA metabolic process (GO:0034587)	2.71704939
58	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.68421471
59	photoreceptor cell maintenance (GO:0045494)	2.67850647
60	auditory receptor cell stereocilium organization (GO:0060088)	2.67327485
61	protein polyglutamylation (GO:0018095)	2.67051708
62	protein localization to cilium (GO:0061512)	2.66433392
63	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.65400411
64	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.64658760
65	cilium organization (GO:0044782)	2.63248022
66	cullin deneddylation (GO:0010388)	2.63017433
67	protein K11-linked deubiquitination (GO:0035871)	2.62065339
68	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.61892853
69	cilium assembly (GO:0042384)	2.60602911
70	ubiquinone biosynthetic process (GO:0006744)	2.58545771
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.56669171
72	photoreceptor cell development (GO:0042461)	2.56298807
73	fucosylation (GO:0036065)	2.55989542
74	transmission of nerve impulse (GO:0019226)	2.55967209
75	somite development (GO:0061053)	2.55168915
76	ubiquinone metabolic process (GO:0006743)	2.54748003
77	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.53717321
78	regulation of telomere maintenance (GO:0032204)	2.52641247
79	neuronal action potential (GO:0019228)	2.51663270
80	tryptophan metabolic process (GO:0006568)	2.51630635
81	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.51601394
82	axonal fasciculation (GO:0007413)	2.51541140
83	glycerophospholipid catabolic process (GO:0046475)	2.51480344
84	regulation of hexokinase activity (GO:1903299)	2.50356519
85	regulation of glucokinase activity (GO:0033131)	2.50356519
86	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.49370107
87	histone H2A acetylation (GO:0043968)	2.47628506
88	intraciliary transport (GO:0042073)	2.47480903
89	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.46871639
90	prenylation (GO:0097354)	2.45896584
91	protein prenylation (GO:0018342)	2.45896584
92	central nervous system projection neuron axonogenesis (GO:0021952)	2.45488070
93	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45257520
94	protein localization to synapse (GO:0035418)	2.44176353
95	head development (GO:0060322)	2.43358150
96	olfactory bulb development (GO:0021772)	2.42843820
97	regulation of axon regeneration (GO:0048679)	2.42788506
98	regulation of neuron projection regeneration (GO:0070570)	2.42788506
99	preassembly of GPI anchor in ER membrane (GO:0016254)	2.42754937
100	resolution of meiotic recombination intermediates (GO:0000712)	2.42080180

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.67957890
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.47986496
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.22716686
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.90098824
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.85170744
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.77481707
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.63253502
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61173468
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.60834179
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.43432813
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.39554018
12	VDR_22108803_ChIP-Seq_LS180_Human	2.37592459
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35047733
14	EWS_26573619_Chip-Seq_HEK293_Human	2.31351644
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.29475910
16	FUS_26573619_Chip-Seq_HEK293_Human	2.21212611
17	P300_19829295_ChIP-Seq_ESCs_Human	2.15967044
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04103137
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04014445
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97679872
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.79179425
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.78985600
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.77887488
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76065928
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73646033
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71513547
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70573799
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66525314
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64431410
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.63882732
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.61756698
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.54739430
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54603638
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53416429
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52633042
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.52633042
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52197780
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52144319
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51919486
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51429007
41	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49492824
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49148626
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48279863
44	AR_25329375_ChIP-Seq_VCAP_Human	1.47817500
45	STAT3_23295773_ChIP-Seq_U87_Human	1.46651997
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43734416
47	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.41761713
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41517443
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40796387
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39077146
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37324232
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37189613
53	TCF4_23295773_ChIP-Seq_U87_Human	1.37137081
54	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36868275
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35300170
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.34835047
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.33829621
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29069617
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29069617
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27996404
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27968470
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27886133
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26814917
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.24008276
65	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.23798949
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23113466
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23027154
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22996697
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21628666
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20528376
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18737006
72	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.17866554
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16135502
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16135502
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15102654
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.14518710
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14012575
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.12485366
79	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10342910
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09980948
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08788415
82	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.06941224
83	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06853423
84	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06278759
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.04753487
86	JUN_21703547_ChIP-Seq_K562_Human	1.01159218
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00407855
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00160216
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99787286
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97533398
91	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.97482178
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97297967
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96737265
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96261257
95	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.95915522
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94021816
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93811679
98	VDR_23849224_ChIP-Seq_CD4+_Human	0.93761255
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92980901
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92762117

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.19053739
2	MP0002102_abnormal_ear_morphology	3.11878239
3	MP0000569_abnormal_digit_pigmentation	2.90975209
4	MP0001968_abnormal_touch/_nociception	2.45886568
5	MP0002736_abnormal_nociception_after	2.42655086
6	MP0001529_abnormal_vocalization	2.31781481
7	MP0008877_abnormal_DNA_methylation	2.24369951
8	MP0006072_abnormal_retinal_apoptosis	2.12909797
9	MP0005551_abnormal_eye_electrophysiolog	2.12702165
10	MP0006276_abnormal_autonomic_nervous	2.09456567
11	MP0006292_abnormal_olfactory_placode	2.08804828
12	MP0005253_abnormal_eye_physiology	1.98805909
13	MP0003646_muscle_fatigue	1.93508340
14	MP0000778_abnormal_nervous_system	1.91720573
15	MP0000631_abnormal_neuroendocrine_gland	1.91684041
16	MP0009046_muscle_twitch	1.87593946
17	MP0008789_abnormal_olfactory_epithelium	1.84484398
18	MP0004142_abnormal_muscle_tone	1.80743865
19	MP0004133_heterotaxia	1.80367713
20	MP0005645_abnormal_hypothalamus_physiol	1.79179603
21	MP0002272_abnormal_nervous_system	1.78125758
22	MP0003195_calcinosis	1.75252128
23	MP0004885_abnormal_endolymph	1.74731103
24	MP0003283_abnormal_digestive_organ	1.70169514
25	MP0003787_abnormal_imprinting	1.70050728
26	MP0009745_abnormal_behavioral_response	1.67631555
27	MP0001486_abnormal_startle_reflex	1.66673369
28	MP0002938_white_spotting	1.63033779
29	MP0002751_abnormal_autonomic_nervous	1.60131503
30	MP0002735_abnormal_chemical_nociception	1.59781249
31	MP0005394_taste/olfaction_phenotype	1.58682577
32	MP0005499_abnormal_olfactory_system	1.58682577
33	MP0001984_abnormal_olfaction	1.57186227
34	MP0000372_irregular_coat_pigmentation	1.56274211
35	MP0002653_abnormal_ependyma_morphology	1.50564577
36	MP0005646_abnormal_pituitary_gland	1.46261192
37	MP0002638_abnormal_pupillary_reflex	1.45851936
38	MP0004924_abnormal_behavior	1.44269321
39	MP0005386_behavior/neurological_phenoty	1.44269321
40	MP0004742_abnormal_vestibular_system	1.43820840
41	MP0005423_abnormal_somatic_nervous	1.43536214
42	MP0002837_dystrophic_cardiac_calcinosis	1.43518495
43	MP0002822_catalepsy	1.40808419
44	MP0002557_abnormal_social/conspecific_i	1.39308642
45	MP0001986_abnormal_taste_sensitivity	1.36599818
46	MP0001485_abnormal_pinna_reflex	1.36439308
47	MP0000427_abnormal_hair_cycle	1.35725170
48	MP0002572_abnormal_emotion/affect_behav	1.35198871
49	MP0003635_abnormal_synaptic_transmissio	1.33463955
50	MP0008872_abnormal_physiological_respon	1.33073279
51	MP0002067_abnormal_sensory_capabilities	1.25751712
52	MP0003136_yellow_coat_color	1.25536362
53	MP0002064_seizures	1.25248552
54	MP0002734_abnormal_mechanical_nocicepti	1.24225291
55	MP0001970_abnormal_pain_threshold	1.23979223
56	MP0003121_genomic_imprinting	1.22025273
57	MP0002184_abnormal_innervation	1.21985331
58	MP0002063_abnormal_learning/memory/cond	1.20364999
59	MP0003011_delayed_dark_adaptation	1.18597704
60	MP0004043_abnormal_pH_regulation	1.18547966
61	MP0002733_abnormal_thermal_nociception	1.18361093
62	MP0004270_analgesia	1.17912330
63	MP0000049_abnormal_middle_ear	1.17476366
64	MP0002234_abnormal_pharynx_morphology	1.16648798
65	MP0008995_early_reproductive_senescence	1.15822614
66	MP0003718_maternal_effect	1.14550424
67	MP0002752_abnormal_somatic_nervous	1.13191802
68	MP0003122_maternal_imprinting	1.12011108
69	MP0003890_abnormal_embryonic-extraembry	1.11753090
70	MP0005187_abnormal_penis_morphology	1.08652244
71	MP0005195_abnormal_posterior_eye	1.05636847
72	MP0001501_abnormal_sleep_pattern	1.03598977
73	MP0002882_abnormal_neuron_morphology	1.03196804
74	MP0000647_abnormal_sebaceous_gland	1.01432494
75	MP0004859_abnormal_synaptic_plasticity	1.00871772
76	MP0000026_abnormal_inner_ear	1.00672708
77	MP0002876_abnormal_thyroid_physiology	1.00069046
78	MP0008058_abnormal_DNA_repair	0.99750947
79	MP0003937_abnormal_limbs/digits/tail_de	0.97556985
80	MP0002160_abnormal_reproductive_system	0.95781407
81	MP0003119_abnormal_digestive_system	0.94899685
82	MP0000955_abnormal_spinal_cord	0.94837968
83	MP0004147_increased_porphyrin_level	0.93911740
84	MP0005391_vision/eye_phenotype	0.91750423
85	MP0002233_abnormal_nose_morphology	0.91336038
86	MP0002095_abnormal_skin_pigmentation	0.90760946
87	MP0001293_anophthalmia	0.90519628
88	MP0001502_abnormal_circadian_rhythm	0.90043882
89	MP0005174_abnormal_tail_pigmentation	0.88538323
90	MP0003698_abnormal_male_reproductive	0.88497509
91	MP0005389_reproductive_system_phenotype	0.84836234
92	MP0001963_abnormal_hearing_physiology	0.83319802
93	MP0002152_abnormal_brain_morphology	0.82043028
94	MP0004145_abnormal_muscle_electrophysio	0.81908841
95	MP0005171_absent_coat_pigmentation	0.81041261
96	MP0003755_abnormal_palate_morphology	0.79789072
97	MP0001905_abnormal_dopamine_level	0.79111792
98	MP0002229_neurodegeneration	0.78584093
99	MP0003137_abnormal_impulse_conducting	0.78179542
100	MP0005084_abnormal_gallbladder_morpholo	0.78004329

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.34561977
2	Abnormality of midbrain morphology (HP:0002418)	4.34561977
3	Pancreatic cysts (HP:0001737)	4.15302292
4	True hermaphroditism (HP:0010459)	4.02426022
5	Pancreatic fibrosis (HP:0100732)	3.90957217
6	Hyperventilation (HP:0002883)	3.58279553
7	Nephronophthisis (HP:0000090)	3.39825209
8	Medial flaring of the eyebrow (HP:0010747)	3.04652459
9	Abnormality of the renal medulla (HP:0100957)	3.03041373
10	Chronic hepatic failure (HP:0100626)	2.92729168
11	Broad-based gait (HP:0002136)	2.84976930
12	Abnormality of the renal cortex (HP:0011035)	2.76957786
13	Gait imbalance (HP:0002141)	2.68515105
14	Cystic liver disease (HP:0006706)	2.64890113
15	Pendular nystagmus (HP:0012043)	2.63030044
16	Congenital stationary night blindness (HP:0007642)	2.61333780
17	Retinal dysplasia (HP:0007973)	2.56636333
18	Congenital primary aphakia (HP:0007707)	2.56057828
19	Anencephaly (HP:0002323)	2.55237598
20	Attenuation of retinal blood vessels (HP:0007843)	2.52802246
21	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.50960735
22	Tubular atrophy (HP:0000092)	2.47425591
23	Type II lissencephaly (HP:0007260)	2.46948602
24	Lissencephaly (HP:0001339)	2.42688590
25	Absent speech (HP:0001344)	2.40736973
26	Nephrogenic diabetes insipidus (HP:0009806)	2.39265345
27	Abolished electroretinogram (ERG) (HP:0000550)	2.33889130
28	Sclerocornea (HP:0000647)	2.33169586
29	Pachygyria (HP:0001302)	2.32313649
30	Optic nerve hypoplasia (HP:0000609)	2.25601049
31	Genital tract atresia (HP:0001827)	2.24138097
32	Postaxial foot polydactyly (HP:0001830)	2.23537476
33	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.22803374
34	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.20454913
35	Hypomagnesemia (HP:0002917)	2.20020387
36	Cerebellar dysplasia (HP:0007033)	2.18677126
37	Vaginal atresia (HP:0000148)	2.18452029
38	Abnormality of the labia minora (HP:0012880)	2.18378975
39	Drooling (HP:0002307)	2.10589409
40	Intestinal atresia (HP:0011100)	2.10434089
41	Polyuria (HP:0000103)	2.09796681
42	Inability to walk (HP:0002540)	2.09729912
43	Septo-optic dysplasia (HP:0100842)	2.09488859
44	Oligodactyly (hands) (HP:0001180)	2.08846237
45	Occipital encephalocele (HP:0002085)	2.08633982
46	Stomach cancer (HP:0012126)	2.08169010
47	Postaxial hand polydactyly (HP:0001162)	2.07982713
48	Small hand (HP:0200055)	2.06244598
49	Methylmalonic acidemia (HP:0002912)	2.05733323
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.00014165
51	Hemiparesis (HP:0001269)	1.98932379
52	Narrow forehead (HP:0000341)	1.98342284
53	Gaze-evoked nystagmus (HP:0000640)	1.98180932
54	Bifid tongue (HP:0010297)	1.97529744
55	Abnormal rod and cone electroretinograms (HP:0008323)	1.96145946
56	Increased corneal curvature (HP:0100692)	1.94828685
57	Keratoconus (HP:0000563)	1.94828685
58	Bony spicule pigmentary retinopathy (HP:0007737)	1.94549133
59	Astigmatism (HP:0000483)	1.94317962
60	Focal seizures (HP:0007359)	1.94258974
61	Congenital hepatic fibrosis (HP:0002612)	1.93652960
62	Tubulointerstitial abnormality (HP:0001969)	1.93617771
63	Colon cancer (HP:0003003)	1.92733884
64	Preaxial hand polydactyly (HP:0001177)	1.92598582
65	Acute necrotizing encephalopathy (HP:0006965)	1.92399486
66	Tented upper lip vermilion (HP:0010804)	1.92060126
67	Polydipsia (HP:0001959)	1.91612427
68	Abnormal drinking behavior (HP:0030082)	1.91612427
69	Progressive inability to walk (HP:0002505)	1.90190118
70	Progressive cerebellar ataxia (HP:0002073)	1.90065266
71	Abnormal biliary tract physiology (HP:0012439)	1.89965414
72	Bile duct proliferation (HP:0001408)	1.89965414
73	Protruding tongue (HP:0010808)	1.89712029
74	Febrile seizures (HP:0002373)	1.89654673
75	Focal motor seizures (HP:0011153)	1.89200322
76	Furrowed tongue (HP:0000221)	1.88301498
77	Male pseudohermaphroditism (HP:0000037)	1.88137935
78	Short tibia (HP:0005736)	1.86996972
79	Progressive macrocephaly (HP:0004481)	1.86784072
80	Tubulointerstitial fibrosis (HP:0005576)	1.85392250
81	Excessive salivation (HP:0003781)	1.84948795
82	Increased CSF lactate (HP:0002490)	1.84640438
83	Dandy-Walker malformation (HP:0001305)	1.84206718
84	Mitochondrial inheritance (HP:0001427)	1.83577623
85	Rib fusion (HP:0000902)	1.83553637
86	Patellar aplasia (HP:0006443)	1.82024008
87	Chorioretinal atrophy (HP:0000533)	1.81959160
88	Renal cortical cysts (HP:0000803)	1.81870965
89	Polyphagia (HP:0002591)	1.81779024
90	Hypoplasia of the pons (HP:0012110)	1.81276838
91	Poor coordination (HP:0002370)	1.81058233
92	Abnormality of the pons (HP:0007361)	1.76742365
93	Hypothermia (HP:0002045)	1.74321078
94	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.73259696
95	Polymicrogyria (HP:0002126)	1.70362265
96	Decreased central vision (HP:0007663)	1.69438493
97	Severe muscular hypotonia (HP:0006829)	1.69004252
98	Aplasia/Hypoplasia of the patella (HP:0006498)	1.68769292
99	Methylmalonic aciduria (HP:0012120)	1.68098354
100	Agitation (HP:0000713)	1.67099527

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.20333440
2	CASK	3.90831660
3	WNK3	3.21776195
4	MAP4K2	2.86431161
5	MARK1	2.61177758
6	NUAK1	2.60171472
7	ZAK	2.54026267
8	MAP3K4	2.52156783
9	PINK1	2.40669560
10	MAPK13	2.38073781
11	TNIK	2.28774872
12	ADRBK2	2.19744291
13	BMPR1B	2.11459763
14	GRK1	1.94832694
15	TLK1	1.91904741
16	MAP2K7	1.91679906
17	TRIM28	1.81806474
18	INSRR	1.78489233
19	EPHA4	1.64182494
20	BCR	1.62975938
21	DYRK2	1.60721884
22	ERBB3	1.47841103
23	MKNK2	1.42319514
24	PAK3	1.28799935
25	VRK1	1.18392180
26	BUB1	1.16741983
27	STK38L	1.10823061
28	WNK4	1.10367217
29	CSNK1G2	1.09296015
30	FER	1.07703530
31	PLK2	1.07608533
32	OXSR1	1.02136209
33	CSNK1G1	1.01831743
34	TAOK3	1.01811094
35	CSNK1G3	0.99755790
36	BRSK2	0.97479656
37	CSNK1A1L	0.94868662
38	SRPK1	0.94749477
39	PHKG1	0.94522306
40	PHKG2	0.94522306
41	STK39	0.87876724
42	PRKCE	0.87732177
43	NTRK3	0.87446043
44	EPHA3	0.84804467
45	NTRK2	0.84329818
46	PRKCG	0.83855935
47	PLK4	0.83215505
48	PNCK	0.82762750
49	PLK3	0.81013421
50	ADRBK1	0.75724928
51	FGFR2	0.74266861
52	EPHB2	0.70403035
53	MST4	0.70239822
54	DAPK2	0.69423861
55	CAMKK2	0.69052697
56	ACVR1B	0.68907497
57	MKNK1	0.67497381
58	SIK2	0.66209159
59	AKT3	0.61528750
60	DYRK3	0.59804906
61	TXK	0.58554074
62	LATS1	0.58269428
63	PLK1	0.56547354
64	KIT	0.56202916
65	MINK1	0.56159938
66	WEE1	0.55295620
67	CDK8	0.54257855
68	PKN1	0.53925495
69	CAMK2A	0.51815548
70	PIK3CA	0.49559294
71	CDK3	0.47360231
72	RPS6KA5	0.46419067
73	SGK494	0.44961382
74	SGK223	0.44961382
75	MAP2K4	0.44870192
76	SGK2	0.44601213
77	ATR	0.44118757
78	PRKACA	0.43276558
79	CSNK1A1	0.42758223
80	CCNB1	0.42505641
81	MUSK	0.42010481
82	OBSCN	0.41729154
83	CDC7	0.40001414
84	MAPK15	0.39548105
85	TGFBR1	0.39149841
86	MAPKAPK5	0.39086143
87	ATM	0.36965489
88	PRKAA1	0.36685819
89	BCKDK	0.36420361
90	VRK2	0.36355003
91	CDK5	0.35474496
92	STK11	0.34207813
93	PRKCI	0.33621385
94	NEK1	0.31688822
95	MARK3	0.30961631
96	CAMK4	0.30630037
97	PRKG1	0.29756765
98	CSNK1D	0.29568126
99	NLK	0.29380600
100	NEK2	0.28944260

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.99221887
2	Nicotine addiction_Homo sapiens_hsa05033	2.88025241
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.62145435
4	Phototransduction_Homo sapiens_hsa04744	2.50485304
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.34154859
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33139163
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25114561
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.20215055
9	Butanoate metabolism_Homo sapiens_hsa00650	2.16035023
10	Protein export_Homo sapiens_hsa03060	2.11858178
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.10504799
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00727432
13	Parkinsons disease_Homo sapiens_hsa05012	1.95425198
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.93149544
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.92881455
16	RNA polymerase_Homo sapiens_hsa03020	1.85996267
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.85559558
18	Propanoate metabolism_Homo sapiens_hsa00640	1.83157475
19	Basal transcription factors_Homo sapiens_hsa03022	1.77676113
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.70926369
21	Homologous recombination_Homo sapiens_hsa03440	1.66358719
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.64805960
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.64667482
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.62888217
25	RNA degradation_Homo sapiens_hsa03018	1.56240471
26	Taste transduction_Homo sapiens_hsa04742	1.51167854
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.47707853
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.46160046
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43056030
30	Morphine addiction_Homo sapiens_hsa05032	1.39172772
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.36143519
32	Huntingtons disease_Homo sapiens_hsa05016	1.29926596
33	Caffeine metabolism_Homo sapiens_hsa00232	1.29365645
34	GABAergic synapse_Homo sapiens_hsa04727	1.29349271
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.29229760
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28252745
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.20693760
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.19353481
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.17125690
40	Circadian entrainment_Homo sapiens_hsa04713	1.13270030
41	Olfactory transduction_Homo sapiens_hsa04740	1.09130083
42	Peroxisome_Homo sapiens_hsa04146	1.05617937
43	Alzheimers disease_Homo sapiens_hsa05010	1.05377781
44	Proteasome_Homo sapiens_hsa03050	0.97172350
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95808767
46	Circadian rhythm_Homo sapiens_hsa04710	0.90804824
47	Regulation of autophagy_Homo sapiens_hsa04140	0.90633685
48	Serotonergic synapse_Homo sapiens_hsa04726	0.90581491
49	Sulfur metabolism_Homo sapiens_hsa00920	0.86346573
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.84640302
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84557736
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.83865572
53	Insulin secretion_Homo sapiens_hsa04911	0.82488829
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.81920261
55	One carbon pool by folate_Homo sapiens_hsa00670	0.80894735
56	Mismatch repair_Homo sapiens_hsa03430	0.80790785
57	Cocaine addiction_Homo sapiens_hsa05030	0.80402314
58	Asthma_Homo sapiens_hsa05310	0.78965889
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76162804
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71404186
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69247066
62	Axon guidance_Homo sapiens_hsa04360	0.69120768
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68664026
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68530691
65	Purine metabolism_Homo sapiens_hsa00230	0.68503975
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.67024903
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66499896
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65138196
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63982677
70	Lysine degradation_Homo sapiens_hsa00310	0.63332431
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.60059682
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59954447
73	Metabolic pathways_Homo sapiens_hsa01100	0.59746897
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59078509
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58524021
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57312648
77	ABC transporters_Homo sapiens_hsa02010	0.55142998
78	Amphetamine addiction_Homo sapiens_hsa05031	0.55077067
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53647917
80	Alcoholism_Homo sapiens_hsa05034	0.52756350
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52503573
82	Fatty acid elongation_Homo sapiens_hsa00062	0.52274313
83	RNA transport_Homo sapiens_hsa03013	0.51848943
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51639594
85	Base excision repair_Homo sapiens_hsa03410	0.50721492
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.48965670
87	Long-term depression_Homo sapiens_hsa04730	0.47166153
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45475018
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42899558
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.42540136
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42355401
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41856130
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41499748
94	Cholinergic synapse_Homo sapiens_hsa04725	0.40742765
95	Oocyte meiosis_Homo sapiens_hsa04114	0.38115475
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37307682
97	Allograft rejection_Homo sapiens_hsa05330	0.36927745
98	Retinol metabolism_Homo sapiens_hsa00830	0.36804343
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.36143214
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.35998768

ZNF250

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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