ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	4.29483144
2	presynaptic membrane organization (GO:0097090)	3.72133070
3	postsynaptic membrane organization (GO:0001941)	3.71704459
4	limb bud formation (GO:0060174)	3.52532416
5	pyrimidine nucleobase catabolic process (GO:0006208)	3.31484220
6	retinal ganglion cell axon guidance (GO:0031290)	3.24930541
7	inositol phosphate catabolic process (GO:0071545)	3.21518000
8	response to pheromone (GO:0019236)	3.14720727
9	axonal fasciculation (GO:0007413)	3.08743331
10	positive regulation of gastrulation (GO:2000543)	3.08712907
11	intraciliary transport (GO:0042073)	3.04010007
12	sympathetic nervous system development (GO:0048485)	2.96656951
13	spinal cord development (GO:0021510)	2.89187753
14	histone H2A acetylation (GO:0043968)	2.88717759
15	nonmotile primary cilium assembly (GO:0035058)	2.84172415
16	limb development (GO:0060173)	2.83267860
17	appendage development (GO:0048736)	2.83267860
18	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.83135254
19	regulation of translation, ncRNA-mediated (GO:0045974)	2.83135254
20	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.83135254
21	olfactory bulb development (GO:0021772)	2.82105163
22	behavioral response to nicotine (GO:0035095)	2.80735075
23	neuron recognition (GO:0008038)	2.78345420
24	regulation of timing of cell differentiation (GO:0048505)	2.76704932
25	cell migration in hindbrain (GO:0021535)	2.70121499
26	retinal cone cell development (GO:0046549)	2.69050170
27	regulation of development, heterochronic (GO:0040034)	2.62452125
28	negative regulation of axon guidance (GO:1902668)	2.62299706
29	nucleobase catabolic process (GO:0046113)	2.62216728
30	cardiac right ventricle morphogenesis (GO:0003215)	2.56354503
31	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.56028630
32	epithelial cilium movement (GO:0003351)	2.54752794
33	piRNA metabolic process (GO:0034587)	2.53601467
34	central nervous system projection neuron axonogenesis (GO:0021952)	2.53360133
35	vocalization behavior (GO:0071625)	2.51906751
36	inner ear receptor stereocilium organization (GO:0060122)	2.51803025
37	behavioral response to ethanol (GO:0048149)	2.50811752
38	regulation of respiratory system process (GO:0044065)	2.48019768
39	auditory behavior (GO:0031223)	2.47935102
40	protein localization to cilium (GO:0061512)	2.46638384
41	neuron cell-cell adhesion (GO:0007158)	2.44116698
42	mechanosensory behavior (GO:0007638)	2.42759522
43	neurotransmitter-gated ion channel clustering (GO:0072578)	2.42193608
44	cornea development in camera-type eye (GO:0061303)	2.42140313
45	regulation of glucokinase activity (GO:0033131)	2.41150862
46	regulation of hexokinase activity (GO:1903299)	2.41150862
47	central nervous system neuron axonogenesis (GO:0021955)	2.40248203
48	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.39622843
49	inositol phosphate dephosphorylation (GO:0046855)	2.39622843
50	pyrimidine dimer repair (GO:0006290)	2.38224751
51	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.37293618
52	positive regulation of dendrite morphogenesis (GO:0050775)	2.36486875
53	forebrain neuron differentiation (GO:0021879)	2.35548421
54	head development (GO:0060322)	2.35008305
55	neural tube formation (GO:0001841)	2.34834930
56	ephrin receptor signaling pathway (GO:0048013)	2.33430831
57	regulation of Rac protein signal transduction (GO:0035020)	2.32903912
58	transmission of nerve impulse (GO:0019226)	2.32070447
59	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.31685352
60	synapse assembly (GO:0007416)	2.31246745
61	negative regulation of astrocyte differentiation (GO:0048712)	2.30294830
62	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.28944163
63	DNA methylation involved in gamete generation (GO:0043046)	2.28384075
64	regulation of meiosis I (GO:0060631)	2.27824535
65	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.27528621
66	somite development (GO:0061053)	2.27269764
67	dendritic spine morphogenesis (GO:0060997)	2.26833359
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.26423157
69	ganglion development (GO:0061548)	2.26284796
70	replication fork processing (GO:0031297)	2.26218843
71	cilium organization (GO:0044782)	2.25918843
72	neuron fate specification (GO:0048665)	2.25212915
73	positive regulation of smoothened signaling pathway (GO:0045880)	2.24765824
74	polyol catabolic process (GO:0046174)	2.23269384
75	smoothened signaling pathway (GO:0007224)	2.22911721
76	positive regulation of embryonic development (GO:0040019)	2.22390113
77	cilium assembly (GO:0042384)	2.20623132
78	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.20580797
79	regulation of dendritic spine morphogenesis (GO:0061001)	2.19851213
80	regulation of axon guidance (GO:1902667)	2.19708485
81	cranial nerve development (GO:0021545)	2.19153018
82	chemosensory behavior (GO:0007635)	2.19127981
83	photoreceptor cell development (GO:0042461)	2.18911168
84	glycosphingolipid biosynthetic process (GO:0006688)	2.18631867
85	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.17330060
86	regulation of telomere maintenance (GO:0032204)	2.17241880
87	auditory receptor cell differentiation (GO:0042491)	2.16382010
88	regulation of growth hormone secretion (GO:0060123)	2.14857216
89	cilium morphogenesis (GO:0060271)	2.14822026
90	cilium movement (GO:0003341)	2.14569791
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.14463764
92	primitive streak formation (GO:0090009)	2.12652501
93	somite rostral/caudal axis specification (GO:0032525)	2.12238337
94	axoneme assembly (GO:0035082)	2.12116484
95	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.11919670
96	negative chemotaxis (GO:0050919)	2.11750595
97	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.11552198
98	regulation of acrosome reaction (GO:0060046)	2.11495070
99	DNA alkylation (GO:0006305)	2.11375456
100	DNA methylation (GO:0006306)	2.11375456

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.55045399
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.65038886
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.43509738
4	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.39011243
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.34954704
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.74819519
7	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.48914561
8	FUS_26573619_Chip-Seq_HEK293_Human	2.39246550
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36300273
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31399678
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.22236070
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.19164300
13	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.11183445
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07724192
15	VDR_22108803_ChIP-Seq_LS180_Human	2.07172159
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07043007
17	EWS_26573619_Chip-Seq_HEK293_Human	2.06890461
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.05875171
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.00651544
20	P300_19829295_ChIP-Seq_ESCs_Human	1.77626813
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.75972046
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69065455
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67148377
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67070329
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.66446868
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.63989362
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60150535
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56023212
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55452996
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.49427681
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48807034
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48409058
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.47265166
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44869794
35	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.43915297
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42881308
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.42480822
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41976200
39	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.38960696
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32888778
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32443949
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32443949
43	STAT3_23295773_ChIP-Seq_U87_Human	1.31549756
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30330085
45	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.30317432
46	AR_25329375_ChIP-Seq_VCAP_Human	1.28904240
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28164807
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25039695
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.24742366
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23772607
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23727663
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23167546
53	TCF4_23295773_ChIP-Seq_U87_Human	1.21995867
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21459616
55	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.20298334
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19632116
57	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.18414218
58	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.18020913
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17843027
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.15805530
61	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.14811532
62	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14266927
63	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.13721270
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.13107251
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13107251
66	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12961610
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11399173
68	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10910897
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10004142
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08689234
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.07747863
72	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.07364255
73	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06862806
74	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.05963103
75	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.04968982
76	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.04867925
77	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.04698493
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04506377
79	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.03227035
80	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.02410351
81	* TP53_22573176_ChIP-Seq_HFKS_Human	1.02163552
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01797948
83	MYC_18940864_ChIP-ChIP_HL60_Human	1.01059547
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99903474
85	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99424487
86	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.98531399
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97924911
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.97691841
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95666576
90	SOX9_26525672_Chip-Seq_HEART_Mouse	0.94617037
91	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.93442914
92	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.92752174
93	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.92675255
94	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.92098173
95	AHR_22903824_ChIP-Seq_MCF-7_Human	0.91570810
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90686991
97	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.90564706
98	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.88835878
99	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.87892147
100	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.87892147

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.64401717
2	MP0006292_abnormal_olfactory_placode	2.39274401
3	MP0000566_synostosis	2.27313497
4	MP0000778_abnormal_nervous_system	2.17909325
5	MP0002102_abnormal_ear_morphology	2.06705602
6	MP0003787_abnormal_imprinting	2.06453816
7	MP0003890_abnormal_embryonic-extraembry	2.02458089
8	MP0003121_genomic_imprinting	1.98777531
9	MP0000569_abnormal_digit_pigmentation	1.84331791
10	MP0003122_maternal_imprinting	1.79721467
11	MP0008789_abnormal_olfactory_epithelium	1.78665695
12	MP0008877_abnormal_DNA_methylation	1.72326927
13	MP0005394_taste/olfaction_phenotype	1.69542287
14	MP0005499_abnormal_olfactory_system	1.69542287
15	MP0006276_abnormal_autonomic_nervous	1.60089790
16	MP0002751_abnormal_autonomic_nervous	1.59726554
17	MP0010030_abnormal_orbit_morphology	1.58111040
18	MP0005551_abnormal_eye_electrophysiolog	1.57935205
19	MP0002184_abnormal_innervation	1.55283175
20	MP0001299_abnormal_eye_distance/	1.54100208
21	MP0003937_abnormal_limbs/digits/tail_de	1.53524321
22	MP0004133_heterotaxia	1.53367095
23	MP0000631_abnormal_neuroendocrine_gland	1.52348529
24	MP0003136_yellow_coat_color	1.49685876
25	MP0002938_white_spotting	1.49076513
26	MP0000049_abnormal_middle_ear	1.44912414
27	MP0001486_abnormal_startle_reflex	1.41054438
28	MP0000427_abnormal_hair_cycle	1.38876334
29	MP0001984_abnormal_olfaction	1.38441772
30	MP0001529_abnormal_vocalization	1.37953215
31	MP0001293_anophthalmia	1.36640699
32	MP0003119_abnormal_digestive_system	1.36563578
33	MP0005423_abnormal_somatic_nervous	1.34377241
34	MP0001968_abnormal_touch/_nociception	1.33502025
35	MP0003755_abnormal_palate_morphology	1.27731582
36	MP0006072_abnormal_retinal_apoptosis	1.26246042
37	MP0002557_abnormal_social/conspecific_i	1.26093338
38	MP0004270_analgesia	1.20021741
39	MP0002928_abnormal_bile_duct	1.19230797
40	MP0002233_abnormal_nose_morphology	1.17601989
41	MP0002638_abnormal_pupillary_reflex	1.17581898
42	MP0003635_abnormal_synaptic_transmissio	1.17316569
43	MP0005253_abnormal_eye_physiology	1.16748693
44	MP0002653_abnormal_ependyma_morphology	1.15128102
45	MP0002282_abnormal_trachea_morphology	1.12242142
46	MP0005171_absent_coat_pigmentation	1.11953515
47	MP0002822_catalepsy	1.11608807
48	MP0003942_abnormal_urinary_system	1.11347266
49	MP0008995_early_reproductive_senescence	1.10355862
50	MP0003861_abnormal_nervous_system	1.09122423
51	MP0003718_maternal_effect	1.09082825
52	MP0002752_abnormal_somatic_nervous	1.08263446
53	MP0000383_abnormal_hair_follicle	1.08037424
54	MP0001502_abnormal_circadian_rhythm	1.08027687
55	MP0008058_abnormal_DNA_repair	1.07793671
56	MP0001286_abnormal_eye_development	1.06680310
57	MP0000955_abnormal_spinal_cord	1.06073152
58	MP0003938_abnormal_ear_development	1.05919867
59	MP0001986_abnormal_taste_sensitivity	1.05868846
60	MP0002272_abnormal_nervous_system	1.05329465
61	MP0000026_abnormal_inner_ear	1.05230495
62	MP0008057_abnormal_DNA_replication	1.05002169
63	MP0003123_paternal_imprinting	1.03994921
64	MP0002234_abnormal_pharynx_morphology	1.03679449
65	MP0002572_abnormal_emotion/affect_behav	1.03401922
66	MP0002736_abnormal_nociception_after	1.02578400
67	MP0003935_abnormal_craniofacial_develop	1.01834349
68	MP0000516_abnormal_urinary_system	1.01468507
69	MP0005367_renal/urinary_system_phenotyp	1.01468507
70	MP0005646_abnormal_pituitary_gland	1.01288264
71	MP0004859_abnormal_synaptic_plasticity	0.99488252
72	MP0003567_abnormal_fetal_cardiomyocyte	0.99429330
73	MP0005391_vision/eye_phenotype	0.99245377
74	MP0002063_abnormal_learning/memory/cond	0.97765047
75	MP0009384_cardiac_valve_regurgitation	0.97648968
76	MP0002882_abnormal_neuron_morphology	0.96969642
77	MP0001485_abnormal_pinna_reflex	0.96878914
78	MP0005386_behavior/neurological_phenoty	0.96841378
79	MP0004924_abnormal_behavior	0.96841378
80	MP0009745_abnormal_behavioral_response	0.94910373
81	MP0005195_abnormal_posterior_eye	0.94902509
82	MP0002116_abnormal_craniofacial_bone	0.94680153
83	MP0002735_abnormal_chemical_nociception	0.93848931
84	MP0002152_abnormal_brain_morphology	0.93698927
85	MP0001177_atelectasis	0.92646409
86	MP0003943_abnormal_hepatobiliary_system	0.92234580
87	MP0002734_abnormal_mechanical_nocicepti	0.91168399
88	MP0000372_irregular_coat_pigmentation	0.91105936
89	MP0000538_abnormal_urinary_bladder	0.89005018
90	MP0003283_abnormal_digestive_organ	0.88465316
91	MP0004885_abnormal_endolymph	0.88192111
92	MP0001324_abnormal_eye_pigmentation	0.85831782
93	MP0002210_abnormal_sex_determination	0.85771529
94	MP0002067_abnormal_sensory_capabilities	0.85103355
95	MP0002697_abnormal_eye_size	0.84172940
96	MP0003195_calcinosis	0.81870374
97	MP0003385_abnormal_body_wall	0.80974647
98	MP0009046_muscle_twitch	0.80427880
99	MP0000428_abnormal_craniofacial_morphol	0.78575365
100	MP0003115_abnormal_respiratory_system	0.77013073

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	3.62401058
2	Intestinal atresia (HP:0011100)	3.54312111
3	Nephronophthisis (HP:0000090)	3.25122903
4	Type II lissencephaly (HP:0007260)	3.16917361
5	Molar tooth sign on MRI (HP:0002419)	3.13988076
6	Abnormality of midbrain morphology (HP:0002418)	3.13988076
7	Hyperventilation (HP:0002883)	3.07973432
8	Cerebellar dysplasia (HP:0007033)	3.06037475
9	Pancreatic cysts (HP:0001737)	3.01308838
10	Abnormality of the astrocytes (HP:0100707)	2.72362965
11	Astrocytoma (HP:0009592)	2.72362965
12	True hermaphroditism (HP:0010459)	2.71690785
13	Ependymoma (HP:0002888)	2.70007459
14	Abnormality of the renal medulla (HP:0100957)	2.65786832
15	Absent speech (HP:0001344)	2.56620257
16	Pancreatic fibrosis (HP:0100732)	2.49662888
17	Abnormality of the lower motor neuron (HP:0002366)	2.48584272
18	Volvulus (HP:0002580)	2.43164875
19	Glioma (HP:0009733)	2.31812056
20	Congenital stationary night blindness (HP:0007642)	2.31562070
21	Occipital encephalocele (HP:0002085)	2.30971205
22	Concave nail (HP:0001598)	2.26820133
23	Retinal dysplasia (HP:0007973)	2.26183912
24	Medial flaring of the eyebrow (HP:0010747)	2.25043192
25	Oligodactyly (hands) (HP:0001180)	2.24093010
26	Gait imbalance (HP:0002141)	2.12146168
27	Hypoplastic ischia (HP:0003175)	2.09193464
28	Protruding tongue (HP:0010808)	2.08712810
29	Anencephaly (HP:0002323)	2.08391337
30	Broad-based gait (HP:0002136)	2.07936509
31	Patellar aplasia (HP:0006443)	2.07373626
32	Cystic liver disease (HP:0006706)	2.07366200
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07352505
34	Lissencephaly (HP:0001339)	2.07236626
35	Tented upper lip vermilion (HP:0010804)	2.03772303
36	Abnormality of the ischium (HP:0003174)	2.02721232
37	Exotropia (HP:0000577)	2.02584334
38	Drooling (HP:0002307)	2.02364540
39	Delayed CNS myelination (HP:0002188)	2.01800478
40	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.99169385
41	Double outlet right ventricle (HP:0001719)	1.99130495
42	Congenital malformation of the right heart (HP:0011723)	1.99130495
43	Congenital primary aphakia (HP:0007707)	1.95051967
44	Infantile muscular hypotonia (HP:0008947)	1.94928526
45	Anophthalmia (HP:0000528)	1.93820223
46	Amblyopia (HP:0000646)	1.93445574
47	Aqueductal stenosis (HP:0002410)	1.93086767
48	Tubulointerstitial nephritis (HP:0001970)	1.89864517
49	Focal motor seizures (HP:0011153)	1.89114040
50	Anterior segment dysgenesis (HP:0007700)	1.87297490
51	Rib fusion (HP:0000902)	1.86200544
52	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85723705
53	Genital tract atresia (HP:0001827)	1.85444547
54	Pendular nystagmus (HP:0012043)	1.85060003
55	Attenuation of retinal blood vessels (HP:0007843)	1.84332387
56	Focal seizures (HP:0007359)	1.82031124
57	Postaxial hand polydactyly (HP:0001162)	1.81926304
58	Gastrointestinal atresia (HP:0002589)	1.81696622
59	Optic nerve hypoplasia (HP:0000609)	1.81187728
60	Shawl scrotum (HP:0000049)	1.78862674
61	Postaxial foot polydactyly (HP:0001830)	1.78577250
62	Hypsarrhythmia (HP:0002521)	1.78426587
63	Preaxial hand polydactyly (HP:0001177)	1.78322090
64	Vaginal atresia (HP:0000148)	1.78295548
65	Abnormality of the parathyroid morphology (HP:0011766)	1.77448076
66	Chorioretinal atrophy (HP:0000533)	1.76932036
67	Severe muscular hypotonia (HP:0006829)	1.76005325
68	Abnormality of the renal cortex (HP:0011035)	1.74271567
69	Narrow forehead (HP:0000341)	1.74179942
70	Growth hormone deficiency (HP:0000824)	1.73768432
71	Tubular atrophy (HP:0000092)	1.73290634
72	EEG with generalized epileptiform discharges (HP:0011198)	1.71964409
73	Bile duct proliferation (HP:0001408)	1.71547189
74	Abnormal biliary tract physiology (HP:0012439)	1.71547189
75	Dandy-Walker malformation (HP:0001305)	1.70957255
76	Excessive salivation (HP:0003781)	1.70592457
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.69710171
78	Medulloblastoma (HP:0002885)	1.69583633
79	Hemivertebrae (HP:0002937)	1.67964054
80	Nephrogenic diabetes insipidus (HP:0009806)	1.67791662
81	Epileptic encephalopathy (HP:0200134)	1.65895535
82	Urethral obstruction (HP:0000796)	1.65263733
83	Midline defect of the nose (HP:0004122)	1.65169697
84	Severe Myopia (HP:0011003)	1.64821587
85	Bifid tongue (HP:0010297)	1.64433411
86	Epileptiform EEG discharges (HP:0011182)	1.63146758
87	Oligodactyly (HP:0012165)	1.62258514
88	Hemiparesis (HP:0001269)	1.62190784
89	Neoplasm of the adrenal cortex (HP:0100641)	1.61595292
90	Congenital hepatic fibrosis (HP:0002612)	1.61568130
91	Optic nerve coloboma (HP:0000588)	1.60772767
92	Amyotrophic lateral sclerosis (HP:0007354)	1.58244282
93	Scrotal hypoplasia (HP:0000046)	1.57857722
94	Short foot (HP:0001773)	1.57317191
95	Micropenis (HP:0000054)	1.57072439
96	Abnormality of the corticospinal tract (HP:0002492)	1.55995831
97	Gonadotropin excess (HP:0000837)	1.54288522
98	Poor coordination (HP:0002370)	1.54026171
99	Disproportionate short-trunk short stature (HP:0003521)	1.53963696
100	Delayed myelination (HP:0012448)	1.53708628

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.47795481
2	MARK1	3.32661591
3	FRK	2.96935669
4	CASK	2.37730656
5	BMPR1B	2.29038097
6	WNK3	2.22681625
7	MAPK13	2.15325652
8	MAPK15	2.15031971
9	PRKD3	2.10031220
10	NTRK3	2.03960956
11	BRSK2	1.98510678
12	EPHA4	1.95956601
13	FGFR2	1.89895962
14	NUAK1	1.82476140
15	MAP3K4	1.82076246
16	PNCK	1.78623835
17	STK16	1.74335998
18	WEE1	1.73722712
19	SIK3	1.70105634
20	BCR	1.69399129
21	ERBB3	1.55762039
22	TNIK	1.54113885
23	MAP4K2	1.53824924
24	STK39	1.46213289
25	NTRK2	1.39756468
26	MAP2K7	1.27726377
27	PAK3	1.24053159
28	SRPK1	1.23365132
29	STK38L	1.22472704
30	ADRBK2	1.22088171
31	EPHB2	1.22067209
32	INSRR	1.21681122
33	MUSK	1.14836872
34	DYRK2	1.12964525
35	WNK4	1.11689569
36	PINK1	1.10628726
37	MKNK2	1.06676674
38	LATS1	1.05254631
39	BRSK1	1.03271758
40	GRK1	1.00908837
41	KSR1	0.98935011
42	AKT3	0.97733623
43	CDK3	0.94945120
44	DYRK1A	0.94300828
45	ACVR1B	0.89584103
46	CSNK1G1	0.87279269
47	PIK3CA	0.82140340
48	SIK2	0.81758289
49	NME1	0.81263310
50	MAP2K4	0.80227086
51	CSNK1G2	0.79964833
52	PRKCE	0.77642889
53	CSNK1A1L	0.74599870
54	BRD4	0.70892375
55	OXSR1	0.70854136
56	TGFBR1	0.70030122
57	PRKD2	0.68207744
58	TSSK6	0.67701971
59	CSNK1G3	0.67494723
60	FLT3	0.67177091
61	FGFR1	0.67129368
62	MINK1	0.66941571
63	PRKCG	0.65926938
64	MET	0.65272948
65	MST4	0.63387287
66	ADRBK1	0.63173132
67	VRK1	0.60686497
68	NEK6	0.59858801
69	TAF1	0.56872332
70	CDC7	0.56669600
71	STK3	0.56553429
72	PLK3	0.56044843
73	ZAK	0.51821668
74	CDK8	0.50541042
75	MAP2K1	0.49609874
76	PRKAA1	0.49208703
77	CSNK1D	0.46573933
78	PLK2	0.45936813
79	BCKDK	0.45007570
80	ROCK1	0.44894035
81	MAPKAPK5	0.44398034
82	PRKCI	0.43578208
83	CDK5	0.43400236
84	MAPKAPK3	0.43180409
85	PHKG2	0.41828147
86	PHKG1	0.41828147
87	MKNK1	0.41180891
88	PKN1	0.40443265
89	CAMK2A	0.38258587
90	ATM	0.37171540
91	CSNK1E	0.37171324
92	TNK2	0.36417192
93	CAMK2B	0.35901063
94	PKN2	0.35656144
95	ATR	0.33667479
96	STK11	0.33484052
97	CSNK1A1	0.32998912
98	PLK1	0.32288839
99	CDK1	0.31809771
100	MAP2K6	0.31768839

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.43207103
2	Nicotine addiction_Homo sapiens_hsa05033	2.41551970
3	Phototransduction_Homo sapiens_hsa04744	2.33420638
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.26163178
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.23776954
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14660130
7	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98796037
8	Circadian rhythm_Homo sapiens_hsa04710	1.97963984
9	Basal transcription factors_Homo sapiens_hsa03022	1.94426833
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.81022345
11	Propanoate metabolism_Homo sapiens_hsa00640	1.80065863
12	Protein export_Homo sapiens_hsa03060	1.77645282
13	Butanoate metabolism_Homo sapiens_hsa00650	1.66221255
14	Basal cell carcinoma_Homo sapiens_hsa05217	1.65456312
15	Taste transduction_Homo sapiens_hsa04742	1.60661902
16	Axon guidance_Homo sapiens_hsa04360	1.55221822
17	RNA polymerase_Homo sapiens_hsa03020	1.54681787
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.49108213
19	Hippo signaling pathway_Homo sapiens_hsa04390	1.40239351
20	Insulin secretion_Homo sapiens_hsa04911	1.34438910
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.34338336
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34304941
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.32386130
24	Cocaine addiction_Homo sapiens_hsa05030	1.30958326
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30708451
26	Wnt signaling pathway_Homo sapiens_hsa04310	1.29774901
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25766472
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.19840075
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19767412
30	Circadian entrainment_Homo sapiens_hsa04713	1.17130546
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.16248175
32	Homologous recombination_Homo sapiens_hsa03440	1.14669282
33	RNA degradation_Homo sapiens_hsa03018	1.13341745
34	Lysine degradation_Homo sapiens_hsa00310	1.13014775
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12751000
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.11237003
37	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.11176596
38	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.11102611
39	Amphetamine addiction_Homo sapiens_hsa05031	1.10978844
40	Morphine addiction_Homo sapiens_hsa05032	1.10978161
41	GABAergic synapse_Homo sapiens_hsa04727	1.10964508
42	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.09308404
43	mRNA surveillance pathway_Homo sapiens_hsa03015	1.07829717
44	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.05894957
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03614225
46	Regulation of autophagy_Homo sapiens_hsa04140	1.02963530
47	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.95698097
48	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.94149785
49	RNA transport_Homo sapiens_hsa03013	0.92455317
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.88872027
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.87190191
52	Glucagon signaling pathway_Homo sapiens_hsa04922	0.86378731
53	Melanogenesis_Homo sapiens_hsa04916	0.85792786
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.83734171
55	Long-term depression_Homo sapiens_hsa04730	0.81494777
56	Olfactory transduction_Homo sapiens_hsa04740	0.81291543
57	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.80905775
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.79706350
59	Base excision repair_Homo sapiens_hsa03410	0.79037940
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.78504210
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74911166
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.74692382
63	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.73805320
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73294952
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.72290204
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.71612029
67	Melanoma_Homo sapiens_hsa05218	0.71567516
68	Cholinergic synapse_Homo sapiens_hsa04725	0.70726295
69	Oocyte meiosis_Homo sapiens_hsa04114	0.70123421
70	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.69811582
71	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.69218155
72	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.68200201
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.67032243
74	ABC transporters_Homo sapiens_hsa02010	0.66776945
75	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.62456935
76	Peroxisome_Homo sapiens_hsa04146	0.62219894
77	Spliceosome_Homo sapiens_hsa03040	0.61254052
78	Cell cycle_Homo sapiens_hsa04110	0.60942213
79	Salivary secretion_Homo sapiens_hsa04970	0.60784138
80	Colorectal cancer_Homo sapiens_hsa05210	0.59324839
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58576232
82	AMPK signaling pathway_Homo sapiens_hsa04152	0.58075619
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.55367652
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.51504874
85	FoxO signaling pathway_Homo sapiens_hsa04068	0.51135481
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51056869
87	p53 signaling pathway_Homo sapiens_hsa04115	0.50579015
88	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47580099
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47129638
90	Gap junction_Homo sapiens_hsa04540	0.44980136
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44828827
92	Linoleic acid metabolism_Homo sapiens_hsa00591	0.44360939
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43995390
94	Renin secretion_Homo sapiens_hsa04924	0.43888472
95	Serotonergic synapse_Homo sapiens_hsa04726	0.43429448
96	Estrogen signaling pathway_Homo sapiens_hsa04915	0.42282388
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.41639971
98	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.41634940
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41014893
100	Tight junction_Homo sapiens_hsa04530	0.39988726

ZNF251

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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