ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of glucokinase activity (GO:0033131)	4.84044037
2	regulation of hexokinase activity (GO:1903299)	4.84044037
3	cellular ketone body metabolic process (GO:0046950)	4.12994055
4	ketone body metabolic process (GO:1902224)	3.92191519
5	positive regulation of glycolytic process (GO:0045821)	3.59651149
6	inositol phosphate catabolic process (GO:0071545)	3.33769616
7	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.30790451
8	regulation of protein glycosylation (GO:0060049)	3.28551777
9	lactate metabolic process (GO:0006089)	3.23548170
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.17689104
11	chemosensory behavior (GO:0007635)	3.13899340
12	keratinocyte development (GO:0003334)	3.12420630
13	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.12078157
14	kidney morphogenesis (GO:0060993)	3.10293930
15	respiratory chain complex IV assembly (GO:0008535)	2.94973212
16	inositol phosphate dephosphorylation (GO:0046855)	2.85067344
17	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.85067344
18	polyol catabolic process (GO:0046174)	2.80922857
19	prenylation (GO:0097354)	2.75452998
20	protein prenylation (GO:0018342)	2.75452998
21	endocrine pancreas development (GO:0031018)	2.74946255
22	branched-chain amino acid catabolic process (GO:0009083)	2.69899402
23	dopamine transport (GO:0015872)	2.66753703
24	positive regulation of macroautophagy (GO:0016239)	2.63709354
25	signal peptide processing (GO:0006465)	2.62676269
26	prostate gland growth (GO:0060736)	2.61823052
27	protein K11-linked deubiquitination (GO:0035871)	2.59997131
28	protein K6-linked ubiquitination (GO:0085020)	2.59567455
29	positive regulation of protein autophosphorylation (GO:0031954)	2.57715890
30	peristalsis (GO:0030432)	2.54841052
31	reflex (GO:0060004)	2.50364444
32	establishment of protein localization to Golgi (GO:0072600)	2.49903566
33	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.49456893
34	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.49456893
35	regulation of translation, ncRNA-mediated (GO:0045974)	2.49456893
36	proline transport (GO:0015824)	2.47786488
37	replication fork processing (GO:0031297)	2.47273310
38	cytochrome complex assembly (GO:0017004)	2.45994464
39	intraciliary transport (GO:0042073)	2.44939757
40	neural tube formation (GO:0001841)	2.44906315
41	regulation of meiosis I (GO:0060631)	2.44087269
42	S-adenosylmethionine metabolic process (GO:0046500)	2.43281981
43	DNA double-strand break processing (GO:0000729)	2.43087050
44	protein localization to cilium (GO:0061512)	2.43024896
45	nonmotile primary cilium assembly (GO:0035058)	2.41834634
46	nitric oxide mediated signal transduction (GO:0007263)	2.39539312
47	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.38228794
48	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.38144735
49	nephron tubule morphogenesis (GO:0072078)	2.37506755
50	nephron epithelium morphogenesis (GO:0072088)	2.37506755
51	presynaptic membrane assembly (GO:0097105)	2.36865972
52	fatty acid transmembrane transport (GO:1902001)	2.35834190
53	ubiquinone metabolic process (GO:0006743)	2.35723905
54	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.34461462
55	response to pheromone (GO:0019236)	2.32382988
56	L-fucose catabolic process (GO:0042355)	2.31786412
57	fucose catabolic process (GO:0019317)	2.31786412
58	L-fucose metabolic process (GO:0042354)	2.31786412
59	photoreceptor cell maintenance (GO:0045494)	2.30816742
60	protein targeting to Golgi (GO:0000042)	2.30685058
61	piRNA metabolic process (GO:0034587)	2.28882057
62	renal tubule morphogenesis (GO:0061333)	2.28739350
63	ubiquinone biosynthetic process (GO:0006744)	2.28067807
64	protein localization to Golgi apparatus (GO:0034067)	2.27244645
65	genitalia morphogenesis (GO:0035112)	2.27221643
66	histone H2A acetylation (GO:0043968)	2.26973187
67	detection of light stimulus involved in visual perception (GO:0050908)	2.26617824
68	detection of light stimulus involved in sensory perception (GO:0050962)	2.26617824
69	single strand break repair (GO:0000012)	2.26046962
70	insulin secretion (GO:0030073)	2.26008072
71	cilium organization (GO:0044782)	2.24330834
72	magnesium ion transport (GO:0015693)	2.23575513
73	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.23428827
74	C4-dicarboxylate transport (GO:0015740)	2.23038384
75	negative regulation of hormone biosynthetic process (GO:0032353)	2.21967677
76	positive regulation of insulin secretion (GO:0032024)	2.21853020
77	cilium assembly (GO:0042384)	2.21590078
78	zinc ion transport (GO:0006829)	2.21372585
79	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.21281126
80	detection of calcium ion (GO:0005513)	2.20913305
81	C-terminal protein amino acid modification (GO:0018410)	2.20456238
82	regulation of telomere maintenance (GO:0032204)	2.19284886
83	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.18393963
84	regulation of neurotransmitter uptake (GO:0051580)	2.17736197
85	limb bud formation (GO:0060174)	2.17672298
86	phasic smooth muscle contraction (GO:0014821)	2.17016050
87	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.16899980
88	protein complex biogenesis (GO:0070271)	2.16562418
89	C-terminal protein lipidation (GO:0006501)	2.16248165
90	preassembly of GPI anchor in ER membrane (GO:0016254)	2.15868768
91	synapsis (GO:0007129)	2.13525326
92	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.13185173
93	peptidyl-histidine modification (GO:0018202)	2.12537517
94	Golgi to endosome transport (GO:0006895)	2.12446914
95	regulation of cell communication by electrical coupling (GO:0010649)	2.11145025
96	carnitine shuttle (GO:0006853)	2.11052082
97	parental behavior (GO:0060746)	2.10284653
98	alanine transport (GO:0032328)	2.10045645
99	mannosylation (GO:0097502)	2.09650375
100	regulation of relaxation of muscle (GO:1901077)	2.09292728

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.43007976
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.28088278
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.93482009
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.87736555
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.82384287
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.71275414
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.69982101
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69378113
9	FUS_26573619_Chip-Seq_HEK293_Human	2.46335969
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37916359
11	VDR_22108803_ChIP-Seq_LS180_Human	2.25776899
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.24692692
13	P300_19829295_ChIP-Seq_ESCs_Human	2.19243924
14	EWS_26573619_Chip-Seq_HEK293_Human	2.18411138
15	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.17622922
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.16738330
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.15837261
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11436150
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04861681
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.96842489
21	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.90526871
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.83374449
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79958212
24	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.77342219
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77255156
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77096287
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75081311
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.68760985
29	STAT3_23295773_ChIP-Seq_U87_Human	1.61475927
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.59771808
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58901368
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58342074
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57050994
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55095036
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.55095036
36	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.54523163
37	AR_25329375_ChIP-Seq_VCAP_Human	1.54366763
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.51079209
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49589939
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48504514
41	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.47253111
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46632807
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45957092
44	TCF4_23295773_ChIP-Seq_U87_Human	1.44116237
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42576638
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38822885
47	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38467665
48	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.38386992
49	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.37965585
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37251973
51	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.36583096
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35746758
53	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35343728
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.34763801
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32772347
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.31398912
57	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.31172899
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.28516877
59	CDX2_22108803_ChIP-Seq_LS180_Human	1.26441454
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26411611
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25912891
62	P53_22387025_ChIP-Seq_ESCs_Mouse	1.23446655
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23112130
64	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21596521
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21272339
66	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19244168
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17258452
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.16691787
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15719501
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15398192
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15398192
72	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15272126
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.14040216
74	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.12646806
75	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.10681534
76	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10597190
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10022672
78	AHR_22903824_ChIP-Seq_MCF-7_Human	1.09215943
79	TP53_22573176_ChIP-Seq_HFKS_Human	1.09104027
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08710353
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08315090
82	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08103848
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.07295391
84	P300_18555785_Chip-Seq_ESCs_Mouse	1.07090490
85	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05218383
86	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04351458
87	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04109299
88	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.03649942
89	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03472706
90	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.03249896
91	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02484513
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00799490
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99683725
94	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.99169331
95	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.99169331
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99133569
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.98459867
98	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.98166406
99	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.97450604
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97446750

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.39973300
2	MP0008877_abnormal_DNA_methylation	3.18898559
3	MP0000569_abnormal_digit_pigmentation	2.82023818
4	MP0009780_abnormal_chondrocyte_physiolo	2.80095201
5	MP0002837_dystrophic_cardiac_calcinosis	2.77157113
6	MP0000372_irregular_coat_pigmentation	2.52245509
7	MP0003787_abnormal_imprinting	2.46851854
8	MP0000427_abnormal_hair_cycle	2.24533422
9	MP0002909_abnormal_adrenal_gland	2.08832677
10	MP0006072_abnormal_retinal_apoptosis	2.03045394
11	MP0002102_abnormal_ear_morphology	1.86983728
12	MP0000516_abnormal_urinary_system	1.80347138
13	MP0005367_renal/urinary_system_phenotyp	1.80347138
14	MP0001984_abnormal_olfaction	1.77854046
15	MP0005551_abnormal_eye_electrophysiolog	1.77243571
16	MP0010234_abnormal_vibrissa_follicle	1.76957476
17	MP0003121_genomic_imprinting	1.72480632
18	MP0002638_abnormal_pupillary_reflex	1.66640290
19	MP0004270_analgesia	1.60628588
20	MP0005253_abnormal_eye_physiology	1.58882078
21	MP0000013_abnormal_adipose_tissue	1.56576076
22	MP0003122_maternal_imprinting	1.53836795
23	MP0005174_abnormal_tail_pigmentation	1.51311262
24	MP0005379_endocrine/exocrine_gland_phen	1.48414849
25	MP0002938_white_spotting	1.46654200
26	MP0009046_muscle_twitch	1.43777264
27	MP0008058_abnormal_DNA_repair	1.40057983
28	MP0004043_abnormal_pH_regulation	1.38174292
29	MP0001944_abnormal_pancreas_morphology	1.38157730
30	MP0005646_abnormal_pituitary_gland	1.37494697
31	MP0005220_abnormal_exocrine_pancreas	1.36709109
32	MP0009697_abnormal_copulation	1.35425833
33	MP0004215_abnormal_myocardial_fiber	1.35355798
34	MP0001529_abnormal_vocalization	1.34604539
35	MP0010678_abnormal_skin_adnexa	1.33493140
36	MP0003646_muscle_fatigue	1.30228693
37	MP0005248_abnormal_Harderian_gland	1.26941281
38	MP0004145_abnormal_muscle_electrophysio	1.25155301
39	MP0003718_maternal_effect	1.22171542
40	MP0002090_abnormal_vision	1.22084072
41	MP0000647_abnormal_sebaceous_gland	1.21781234
42	MP0003252_abnormal_bile_duct	1.19042926
43	MP0010386_abnormal_urinary_bladder	1.18965372
44	MP0001986_abnormal_taste_sensitivity	1.15589073
45	MP0002272_abnormal_nervous_system	1.14607695
46	MP0008057_abnormal_DNA_replication	1.13213610
47	MP0003890_abnormal_embryonic-extraembry	1.12735545
48	MP0005332_abnormal_amino_acid	1.11557381
49	MP0000383_abnormal_hair_follicle	1.11262346
50	MP0001661_extended_life_span	1.10918120
51	MP0000631_abnormal_neuroendocrine_gland	1.10271343
52	MP0005408_hypopigmentation	1.09061468
53	MP0002163_abnormal_gland_morphology	1.08053136
54	MP0003283_abnormal_digestive_organ	1.06871040
55	MP0001485_abnormal_pinna_reflex	1.05619800
56	MP0005386_behavior/neurological_phenoty	1.05294047
57	MP0004924_abnormal_behavior	1.05294047
58	MP0005187_abnormal_penis_morphology	1.03647857
59	MP0002734_abnormal_mechanical_nocicepti	1.03126621
60	MP0002693_abnormal_pancreas_physiology	1.03018940
61	MP0002751_abnormal_autonomic_nervous	1.02681869
62	MP0003123_paternal_imprinting	1.02411118
63	MP0002876_abnormal_thyroid_physiology	1.01070218
64	MP0005075_abnormal_melanosome_morpholog	1.00817938
65	MP0008872_abnormal_physiological_respon	0.99220005
66	MP0006036_abnormal_mitochondrial_physio	0.98940384
67	MP0003950_abnormal_plasma_membrane	0.98210960
68	MP0002184_abnormal_innervation	0.97026838
69	MP0003868_abnormal_feces_composition	0.96850557
70	MP0009745_abnormal_behavioral_response	0.96541374
71	MP0002928_abnormal_bile_duct	0.95226436
72	MP0002095_abnormal_skin_pigmentation	0.94808412
73	MP0010329_abnormal_lipoprotein_level	0.92126324
74	MP0002557_abnormal_social/conspecific_i	0.92046086
75	MP0006276_abnormal_autonomic_nervous	0.90944127
76	MP0000538_abnormal_urinary_bladder	0.90237951
77	MP0004085_abnormal_heartbeat	0.90162858
78	MP0002078_abnormal_glucose_homeostasis	0.88262190
79	MP0001324_abnormal_eye_pigmentation	0.86555718
80	MP0003136_yellow_coat_color	0.85401916
81	MP0005645_abnormal_hypothalamus_physiol	0.85077157
82	MP0003937_abnormal_limbs/digits/tail_de	0.85010417
83	MP0000015_abnormal_ear_pigmentation	0.84235265
84	MP0005171_absent_coat_pigmentation	0.84110994
85	MP0001756_abnormal_urination	0.83568609
86	MP0001968_abnormal_touch/_nociception	0.82133099
87	MP0004142_abnormal_muscle_tone	0.81884385
88	MP0006035_abnormal_mitochondrial_morpho	0.81536977
89	MP0002234_abnormal_pharynx_morphology	0.81511592
90	MP0004885_abnormal_endolymph	0.80482985
91	MP0001486_abnormal_startle_reflex	0.80123063
92	MP0005395_other_phenotype	0.78304371
93	MP0000462_abnormal_digestive_system	0.77533616
94	MP0002160_abnormal_reproductive_system	0.77274850
95	MP0005084_abnormal_gallbladder_morpholo	0.77137603
96	MP0003786_premature_aging	0.76482119
97	MP0001666_abnormal_nutrient_absorption	0.75244951
98	MP0000778_abnormal_nervous_system	0.75139871
99	MP0005389_reproductive_system_phenotype	0.75082995
100	MP0005085_abnormal_gallbladder_physiolo	0.72513766

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	4.08526251
2	Ketoacidosis (HP:0001993)	3.92684437
3	Hypothermia (HP:0002045)	3.58674352
4	Hyperglycemia (HP:0003074)	3.47348338
5	Hypoglycemic coma (HP:0001325)	3.39204101
6	Hypoglycemic seizures (HP:0002173)	3.29629817
7	Pancreatic cysts (HP:0001737)	3.11744931
8	Intestinal atresia (HP:0011100)	3.11202760
9	Calf muscle hypertrophy (HP:0008981)	3.02842173
10	Abnormality of the renal cortex (HP:0011035)	2.84489976
11	Muscle hypertrophy of the lower extremities (HP:0008968)	2.84487386
12	Renal cortical cysts (HP:0000803)	2.70900668
13	Nephronophthisis (HP:0000090)	2.65821017
14	Hyperventilation (HP:0002883)	2.65158495
15	Abnormality of midbrain morphology (HP:0002418)	2.63245993
16	Molar tooth sign on MRI (HP:0002419)	2.63245993
17	Pancreatic fibrosis (HP:0100732)	2.62446563
18	True hermaphroditism (HP:0010459)	2.60914073
19	Abnormality of endocrine pancreas physiology (HP:0012093)	2.60514116
20	Abnormality of the pancreatic islet cells (HP:0006476)	2.60514116
21	Medial flaring of the eyebrow (HP:0010747)	2.54013469
22	Ketosis (HP:0001946)	2.54008463
23	Progressive macrocephaly (HP:0004481)	2.49515937
24	Abnormality of the astrocytes (HP:0100707)	2.43775091
25	Astrocytoma (HP:0009592)	2.43775091
26	Abnormality of the renal medulla (HP:0100957)	2.40498675
27	Gaze-evoked nystagmus (HP:0000640)	2.38085068
28	Large for gestational age (HP:0001520)	2.36978552
29	Prominent metopic ridge (HP:0005487)	2.36642257
30	Ependymoma (HP:0002888)	2.36456246
31	Hypomagnesemia (HP:0002917)	2.30719509
32	Neoplasm of the adrenal cortex (HP:0100641)	2.29480053
33	Abnormality of the metopic suture (HP:0005556)	2.27599411
34	Congenital stationary night blindness (HP:0007642)	2.24507992
35	Fair hair (HP:0002286)	2.20619448
36	Acute necrotizing encephalopathy (HP:0006965)	2.20598791
37	EEG with generalized epileptiform discharges (HP:0011198)	2.19768049
38	Glioma (HP:0009733)	2.19518440
39	Pancreatic islet-cell hyperplasia (HP:0004510)	2.17589926
40	Volvulus (HP:0002580)	2.17428083
41	Hypsarrhythmia (HP:0002521)	2.17357552
42	Insulin-resistant diabetes mellitus (HP:0000831)	2.15880424
43	Thyroiditis (HP:0100646)	2.14258125
44	Epileptiform EEG discharges (HP:0011182)	2.13824696
45	Hemiparesis (HP:0001269)	2.13258167
46	Hamartoma of the eye (HP:0010568)	2.10045305
47	Abnormality of the labia minora (HP:0012880)	2.08296709
48	Neoplasm of the adrenal gland (HP:0100631)	2.07734268
49	Symptomatic seizures (HP:0011145)	2.07293145
50	Acute encephalopathy (HP:0006846)	2.04349888
51	Type II lissencephaly (HP:0007260)	2.02918757
52	Neuroendocrine neoplasm (HP:0100634)	2.00175131
53	Progressive inability to walk (HP:0002505)	1.99105237
54	Proximal tubulopathy (HP:0000114)	1.98806847
55	Abnormal biliary tract morphology (HP:0012440)	1.98554642
56	Chronic hepatic failure (HP:0100626)	1.97769412
57	Gait imbalance (HP:0002141)	1.96280887
58	Congenital malformation of the right heart (HP:0011723)	1.93333696
59	Double outlet right ventricle (HP:0001719)	1.93333696
60	Abnormal drinking behavior (HP:0030082)	1.92942872
61	Polydipsia (HP:0001959)	1.92942872
62	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.92571660
63	Hypoplasia of the fovea (HP:0007750)	1.92571660
64	Congenital primary aphakia (HP:0007707)	1.92417677
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.90966049
66	Late onset (HP:0003584)	1.89680103
67	Methylmalonic acidemia (HP:0002912)	1.88023357
68	Thyroid carcinoma (HP:0002890)	1.87294885
69	Increased CSF lactate (HP:0002490)	1.86922954
70	Genital tract atresia (HP:0001827)	1.86612060
71	Tubular atrophy (HP:0000092)	1.85243895
72	Abnormality of vitamin B metabolism (HP:0004340)	1.80799544
73	Papillary thyroid carcinoma (HP:0002895)	1.79871763
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79154179
75	Generalized hypopigmentation of hair (HP:0011358)	1.78837407
76	Abnormality of the calf musculature (HP:0001430)	1.77985599
77	Congenital sensorineural hearing impairment (HP:0008527)	1.77557737
78	Vaginal atresia (HP:0000148)	1.77286984
79	Poor suck (HP:0002033)	1.75767480
80	Furrowed tongue (HP:0000221)	1.75752432
81	Broad-based gait (HP:0002136)	1.73911319
82	Aqueductal stenosis (HP:0002410)	1.73511278
83	Abnormal mitochondria in muscle tissue (HP:0008316)	1.73269109
84	Abnormality of chromosome stability (HP:0003220)	1.72211360
85	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.71591099
86	Attenuation of retinal blood vessels (HP:0007843)	1.71309567
87	Mitochondrial inheritance (HP:0001427)	1.70759266
88	Male pseudohermaphroditism (HP:0000037)	1.70625643
89	Abnormality of urine glucose concentration (HP:0011016)	1.69818974
90	Glycosuria (HP:0003076)	1.69818974
91	Cystic liver disease (HP:0006706)	1.68989976
92	Nephrogenic diabetes insipidus (HP:0009806)	1.67629408
93	Abnormality of methionine metabolism (HP:0010901)	1.66797121
94	Inability to walk (HP:0002540)	1.66779586
95	Gastrointestinal atresia (HP:0002589)	1.65967337
96	Cerebral edema (HP:0002181)	1.62354996
97	Tongue fasciculations (HP:0001308)	1.62318049
98	Fetal akinesia sequence (HP:0001989)	1.60798861
99	Biliary tract neoplasm (HP:0100574)	1.60074680
100	Muscular hypotonia of the trunk (HP:0008936)	1.59762766

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.24301065
2	WNK3	2.47310764
3	TRIM28	2.33734198
4	PINK1	2.30397412
5	ACVR1B	2.23069480
6	BMPR1B	2.21378009
7	FGFR2	2.16267349
8	PHKG2	2.15861697
9	PHKG1	2.15861697
10	TNIK	1.98935144
11	OBSCN	1.95164369
12	MAP4K2	1.93742762
13	STK39	1.90195249
14	CASK	1.89069728
15	ERBB3	1.81028689
16	BRSK2	1.67400001
17	EIF2AK3	1.66679065
18	MAPK13	1.65673675
19	MAP3K4	1.65356904
20	NUAK1	1.60433179
21	GRK1	1.55940881
22	MST4	1.54612671
23	MAPKAPK3	1.51682198
24	MAP3K12	1.49629177
25	MKNK2	1.48135873
26	STK38L	1.46321404
27	PAK3	1.45457284
28	EIF2AK1	1.39888650
29	OXSR1	1.32957325
30	PLK2	1.32948412
31	CSNK1G1	1.31501162
32	ADRBK2	1.31360322
33	ZAK	1.26336661
34	INSRR	1.24412405
35	FER	1.18721405
36	PLK3	1.15404694
37	BCR	1.13490537
38	WNK4	1.11191724
39	PRKCE	1.06705780
40	CSNK1G2	1.02955223
41	STK3	1.01760061
42	TRPM7	0.98230959
43	AKT3	0.97583165
44	CSNK1G3	0.95644420
45	MAP2K7	0.91639085
46	CSNK1A1L	0.85801807
47	PNCK	0.84230357
48	NTRK3	0.83714133
49	PDK2	0.83519060
50	NEK1	0.77003430
51	SRPK1	0.71809071
52	TSSK6	0.70819400
53	NLK	0.70438753
54	CAMK2D	0.69005742
55	DAPK2	0.68772125
56	PRKAA2	0.66054603
57	LATS1	0.64524373
58	STK16	0.62165266
59	PRKD3	0.62072393
60	LMTK2	0.60666245
61	PRKCG	0.59207998
62	PTK2B	0.57137960
63	PRKAA1	0.56433876
64	PIK3CA	0.55607293
65	PRKCI	0.55216301
66	PBK	0.53884564
67	EIF2AK2	0.53160633
68	ATM	0.52289070
69	MAP2K4	0.51763591
70	NEK6	0.51156525
71	PLK1	0.50925673
72	TLK1	0.50726346
73	MINK1	0.50609768
74	MKNK1	0.49749876
75	ADRBK1	0.48717741
76	MARK1	0.47923704
77	TAF1	0.47024568
78	CSNK1A1	0.47001272
79	CSNK1D	0.46949868
80	FGFR1	0.46311435
81	SGK2	0.45277531
82	ERBB4	0.45053189
83	MAP3K2	0.44869238
84	CAMK2A	0.44772780
85	CAMKK2	0.43441449
86	MET	0.43336367
87	YES1	0.42716424
88	PASK	0.41860275
89	MUSK	0.41485677
90	ROCK1	0.41042698
91	SCYL2	0.40985513
92	FGFR3	0.39148946
93	TTK	0.36797907
94	WEE1	0.36692574
95	PRKACA	0.36448514
96	RPS6KA4	0.35664604
97	PRKACB	0.34810323
98	PRKG1	0.34276975
99	RPS6KB2	0.34237200
100	PKN1	0.33970481

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.00793248
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.15982583
3	Butanoate metabolism_Homo sapiens_hsa00650	2.77318716
4	Protein export_Homo sapiens_hsa03060	2.70252884
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.45007255
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.43506725
7	Propanoate metabolism_Homo sapiens_hsa00640	2.36070458
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.16891321
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11803517
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.87764172
11	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.76889147
12	Circadian rhythm_Homo sapiens_hsa04710	1.71488981
13	Insulin secretion_Homo sapiens_hsa04911	1.68788067
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.53473794
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.51338497
16	Phototransduction_Homo sapiens_hsa04744	1.50939707
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.47981081
18	Regulation of autophagy_Homo sapiens_hsa04140	1.45992357
19	Caffeine metabolism_Homo sapiens_hsa00232	1.45470715
20	Peroxisome_Homo sapiens_hsa04146	1.41760110
21	Fatty acid elongation_Homo sapiens_hsa00062	1.41263214
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38304261
23	Sulfur metabolism_Homo sapiens_hsa00920	1.38033935
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.32305830
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.29381698
26	Basal transcription factors_Homo sapiens_hsa03022	1.18475718
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17871966
28	Fatty acid degradation_Homo sapiens_hsa00071	1.15862606
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15112039
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.14030910
31	RNA polymerase_Homo sapiens_hsa03020	1.14019640
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12117903
33	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.10407217
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.09894105
35	Retinol metabolism_Homo sapiens_hsa00830	1.05750915
36	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.01809376
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00883701
38	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98024221
39	beta-Alanine metabolism_Homo sapiens_hsa00410	0.96108059
40	Parkinsons disease_Homo sapiens_hsa05012	0.95732125
41	Folate biosynthesis_Homo sapiens_hsa00790	0.94499123
42	Homologous recombination_Homo sapiens_hsa03440	0.94408295
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93870842
44	RNA degradation_Homo sapiens_hsa03018	0.93565992
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.92934237
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.89299136
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89014022
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.87997967
49	Renin secretion_Homo sapiens_hsa04924	0.86057411
50	ABC transporters_Homo sapiens_hsa02010	0.85669440
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85279098
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84447940
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83069225
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82983305
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.81088688
56	Circadian entrainment_Homo sapiens_hsa04713	0.80986876
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80624469
58	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.80507765
59	Glucagon signaling pathway_Homo sapiens_hsa04922	0.78121940
60	Nicotine addiction_Homo sapiens_hsa05033	0.75779214
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.75269837
62	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75213898
63	One carbon pool by folate_Homo sapiens_hsa00670	0.73290087
64	Taste transduction_Homo sapiens_hsa04742	0.71636599
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71590924
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71463420
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.70975413
68	Alzheimers disease_Homo sapiens_hsa05010	0.70738602
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.69619649
70	Metabolic pathways_Homo sapiens_hsa01100	0.68782652
71	Proteasome_Homo sapiens_hsa03050	0.68244232
72	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.67767266
73	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.66218305
74	Purine metabolism_Homo sapiens_hsa00230	0.66082714
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64806455
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63367646
77	Amphetamine addiction_Homo sapiens_hsa05031	0.63187862
78	Glutathione metabolism_Homo sapiens_hsa00480	0.60829352
79	Type II diabetes mellitus_Homo sapiens_hsa04930	0.58428761
80	Histidine metabolism_Homo sapiens_hsa00340	0.56638749
81	Huntingtons disease_Homo sapiens_hsa05016	0.56340335
82	Serotonergic synapse_Homo sapiens_hsa04726	0.56208340
83	Oocyte meiosis_Homo sapiens_hsa04114	0.55306102
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.54721043
85	Lysine degradation_Homo sapiens_hsa00310	0.53617797
86	GABAergic synapse_Homo sapiens_hsa04727	0.53203414
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52628559
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.51147816
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.49743499
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.49672703
91	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.49194334
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47097349
93	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46925207
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.46475040
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.45493579
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.44823610
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43626351
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42902086
99	Morphine addiction_Homo sapiens_hsa05032	0.42900208
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.42081110

ZNF252P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »