ZNF254

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.27842162
2limb bud formation (GO:0060174)4.18591602
3neural tube formation (GO:0001841)4.09053328
4presynaptic membrane assembly (GO:0097105)3.76019425
5intraciliary transport (GO:0042073)3.75955943
6DNA double-strand break processing (GO:0000729)3.70074127
7response to pheromone (GO:0019236)3.67944193
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53677066
9somite development (GO:0061053)3.51407058
10presynaptic membrane organization (GO:0097090)3.39734301
11nucleobase catabolic process (GO:0046113)3.35149385
12prenylation (GO:0097354)3.22714601
13protein prenylation (GO:0018342)3.22714601
14behavioral response to nicotine (GO:0035095)3.20167161
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.20011379
16epithelial cilium movement (GO:0003351)3.13393011
17positive regulation of mitochondrial fission (GO:0090141)3.12553665
18negative regulation of translation, ncRNA-mediated (GO:0040033)3.08370519
19regulation of translation, ncRNA-mediated (GO:0045974)3.08370519
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08370519
21regulation of development, heterochronic (GO:0040034)3.02623764
22nonmotile primary cilium assembly (GO:0035058)2.98921203
23protein localization to cilium (GO:0061512)2.97968651
24replication fork processing (GO:0031297)2.95540590
25olfactory bulb development (GO:0021772)2.94595701
26negative regulation of DNA recombination (GO:0045910)2.93984571
27resolution of meiotic recombination intermediates (GO:0000712)2.93747420
28cilium morphogenesis (GO:0060271)2.91364168
29regulation of timing of cell differentiation (GO:0048505)2.89747970
30neuron cell-cell adhesion (GO:0007158)2.87687519
31forebrain neuron differentiation (GO:0021879)2.84009766
32mechanosensory behavior (GO:0007638)2.83177227
33protein polyglutamylation (GO:0018095)2.80621611
34cornea development in camera-type eye (GO:0061303)2.79962760
35microtubule anchoring (GO:0034453)2.79780015
36regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.77207044
37negative regulation of transcription regulatory region DNA binding (GO:2000678)2.76373355
38otic vesicle formation (GO:0030916)2.75647738
39retinal ganglion cell axon guidance (GO:0031290)2.73112198
40somatic hypermutation of immunoglobulin genes (GO:0016446)2.70696437
41somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70696437
42cilium organization (GO:0044782)2.70028830
43regulation of telomere maintenance (GO:0032204)2.69913151
44DNA damage response, detection of DNA damage (GO:0042769)2.69531593
45cilium assembly (GO:0042384)2.66656569
46RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66566100
47kidney morphogenesis (GO:0060993)2.62482877
48fucose catabolic process (GO:0019317)2.62464623
49L-fucose metabolic process (GO:0042354)2.62464623
50L-fucose catabolic process (GO:0042355)2.62464623
51regulation of cilium movement (GO:0003352)2.62158448
52sympathetic nervous system development (GO:0048485)2.61120404
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59913376
54regulation of glucokinase activity (GO:0033131)2.53939281
55regulation of hexokinase activity (GO:1903299)2.53939281
56inner ear receptor stereocilium organization (GO:0060122)2.53604990
57platelet dense granule organization (GO:0060155)2.51992024
58regulation of helicase activity (GO:0051095)2.51974493
59regulation of DNA endoreduplication (GO:0032875)2.51854643
60DNA integration (GO:0015074)2.50858033
61regulation of collateral sprouting (GO:0048670)2.50605518
62cilium movement (GO:0003341)2.50089583
63axoneme assembly (GO:0035082)2.49555082
64reciprocal meiotic recombination (GO:0007131)2.46970695
65reciprocal DNA recombination (GO:0035825)2.46970695
66regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.45413693
67neurotransmitter catabolic process (GO:0042135)2.45374950
68spermatid nucleus differentiation (GO:0007289)2.45117633
69protein K6-linked ubiquitination (GO:0085020)2.44631107
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.42793153
71regulation of non-canonical Wnt signaling pathway (GO:2000050)2.42170982
72regulation of sarcomere organization (GO:0060297)2.42100589
73reflex (GO:0060004)2.41776803
74spinal cord motor neuron differentiation (GO:0021522)2.41598774
75head development (GO:0060322)2.41572485
76preassembly of GPI anchor in ER membrane (GO:0016254)2.40841410
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.40608464
78central nervous system projection neuron axonogenesis (GO:0021952)2.40382226
79auditory behavior (GO:0031223)2.38933333
80limb development (GO:0060173)2.38452354
81appendage development (GO:0048736)2.38452354
82smoothened signaling pathway (GO:0007224)2.38292869
83hindbrain development (GO:0030902)2.37997126
84centriole replication (GO:0007099)2.37972091
85water-soluble vitamin biosynthetic process (GO:0042364)2.37797565
86cullin deneddylation (GO:0010388)2.37340388
87recombinational repair (GO:0000725)2.35674842
88cellular response to sterol (GO:0036315)2.34522236
89startle response (GO:0001964)2.34315884
90regulation of mitotic spindle checkpoint (GO:1903504)2.32946884
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.32946884
92embryonic epithelial tube formation (GO:0001838)2.32025777
93pancreas development (GO:0031016)2.31650123
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.31281116
95double-strand break repair via homologous recombination (GO:0000724)2.30382265
96behavioral response to ethanol (GO:0048149)2.29788071
97cell differentiation in spinal cord (GO:0021515)2.29332889
98axonal fasciculation (GO:0007413)2.28690836
99glycosphingolipid biosynthetic process (GO:0006688)2.28629996
100DNA demethylation (GO:0080111)2.28513535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.38919552
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.32865310
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14296391
4GBX2_23144817_ChIP-Seq_PC3_Human3.00389839
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.92722845
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84538343
7* IGF1R_20145208_ChIP-Seq_DFB_Human2.76879985
8FUS_26573619_Chip-Seq_HEK293_Human2.63637269
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59525390
10VDR_22108803_ChIP-Seq_LS180_Human2.54206674
11EWS_26573619_Chip-Seq_HEK293_Human2.50018646
12TAF15_26573619_Chip-Seq_HEK293_Human2.45135627
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40155528
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32400686
15P300_19829295_ChIP-Seq_ESCs_Human2.18604057
16* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14215535
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.12309859
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00538612
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89952024
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87620502
21EZH2_22144423_ChIP-Seq_EOC_Human1.87285070
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83226487
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77565585
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77493836
25ELK1_19687146_ChIP-ChIP_HELA_Human1.75425433
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72754166
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.69338399
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68869388
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68862582
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.67937768
31ER_23166858_ChIP-Seq_MCF-7_Human1.67654826
32IRF1_19129219_ChIP-ChIP_H3396_Human1.67574503
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66981629
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.65251279
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64569274
36SMAD4_21799915_ChIP-Seq_A2780_Human1.63874744
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63548458
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62642277
39* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59266342
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58770606
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56163733
42CBP_20019798_ChIP-Seq_JUKART_Human1.56163733
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52367914
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50975035
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48779091
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48637148
47STAT3_23295773_ChIP-Seq_U87_Human1.47618530
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.45835062
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45460601
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45460601
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44320794
52RNF2_27304074_Chip-Seq_NSC_Mouse1.43603289
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42225452
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41959030
55MYC_18940864_ChIP-ChIP_HL60_Human1.38762409
56* TCF4_23295773_ChIP-Seq_U87_Human1.37800571
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.37191891
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35160858
59AR_25329375_ChIP-Seq_VCAP_Human1.34906623
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.32566156
61BCAT_22108803_ChIP-Seq_LS180_Human1.30554691
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28860270
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28841306
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26834865
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26217400
66RUNX2_22187159_ChIP-Seq_PCA_Human1.24655865
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.23531193
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23254414
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22969694
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21328983
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.20528752
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19643715
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18620002
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18346083
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.18336883
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.17288640
77TCF4_22108803_ChIP-Seq_LS180_Human1.17204957
78SOX2_19829295_ChIP-Seq_ESCs_Human1.17046780
79NANOG_19829295_ChIP-Seq_ESCs_Human1.17046780
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15653354
81AR_21572438_ChIP-Seq_LNCaP_Human1.15140527
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14628263
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11818374
84VDR_23849224_ChIP-Seq_CD4+_Human1.11644938
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10210414
86* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10197114
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.09408807
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09274042
89TP53_22573176_ChIP-Seq_HFKS_Human1.09126845
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06106913
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.05428777
92P53_22387025_ChIP-Seq_ESCs_Mouse1.04814566
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04266037
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00489495
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98706956
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.98290830
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98287050
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.97734735
99* SOX2_21211035_ChIP-Seq_LN229_Gbm0.96024298
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95696376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.35846229
2MP0003787_abnormal_imprinting2.93658077
3MP0003880_abnormal_central_pattern2.54381371
4MP0001529_abnormal_vocalization2.42528560
5MP0000569_abnormal_digit_pigmentation2.38975662
6MP0002102_abnormal_ear_morphology2.34097768
7MP0006292_abnormal_olfactory_placode2.32252381
8MP0003121_genomic_imprinting2.28845078
9MP0006072_abnormal_retinal_apoptosis2.14106783
10MP0008995_early_reproductive_senescence2.02242675
11MP0008789_abnormal_olfactory_epithelium1.98650771
12MP0000778_abnormal_nervous_system1.96751461
13MP0004133_heterotaxia1.95546675
14MP0001984_abnormal_olfaction1.92783621
15MP0003122_maternal_imprinting1.89445735
16MP0002938_white_spotting1.84805541
17MP0003195_calcinosis1.79595453
18MP0008058_abnormal_DNA_repair1.78164668
19MP0005253_abnormal_eye_physiology1.72522409
20MP0006276_abnormal_autonomic_nervous1.72155415
21MP0001293_anophthalmia1.71032039
22MP0005499_abnormal_olfactory_system1.70820497
23MP0005394_taste/olfaction_phenotype1.70820497
24MP0003890_abnormal_embryonic-extraembry1.70561272
25MP0003136_yellow_coat_color1.66650013
26MP0002736_abnormal_nociception_after1.65834521
27MP0000631_abnormal_neuroendocrine_gland1.62192968
28MP0003567_abnormal_fetal_cardiomyocyte1.58611175
29MP0002751_abnormal_autonomic_nervous1.55694628
30MP0002822_catalepsy1.55197844
31MP0001486_abnormal_startle_reflex1.54795412
32MP0000372_irregular_coat_pigmentation1.51515003
33MP0005551_abnormal_eye_electrophysiolog1.50014894
34MP0005645_abnormal_hypothalamus_physiol1.48172591
35MP0002653_abnormal_ependyma_morphology1.46400016
36MP0001968_abnormal_touch/_nociception1.42012387
37MP0003937_abnormal_limbs/digits/tail_de1.41785796
38MP0003119_abnormal_digestive_system1.40610968
39MP0002638_abnormal_pupillary_reflex1.37571998
40MP0002233_abnormal_nose_morphology1.34754683
41MP0002735_abnormal_chemical_nociception1.30840840
42MP0005646_abnormal_pituitary_gland1.29460768
43MP0004885_abnormal_endolymph1.28469862
44MP0010094_abnormal_chromosome_stability1.27316582
45MP0005423_abnormal_somatic_nervous1.14552336
46MP0009046_muscle_twitch1.13037679
47MP0002234_abnormal_pharynx_morphology1.12838558
48MP0002272_abnormal_nervous_system1.12497172
49MP0004215_abnormal_myocardial_fiber1.11900664
50MP0000516_abnormal_urinary_system1.10833885
51MP0005367_renal/urinary_system_phenotyp1.10833885
52MP0005391_vision/eye_phenotype1.10369557
53MP0004270_analgesia1.10116910
54MP0001286_abnormal_eye_development1.10009742
55MP0005187_abnormal_penis_morphology1.09978998
56MP0001986_abnormal_taste_sensitivity1.09200166
57MP0000049_abnormal_middle_ear1.08693725
58MP0009697_abnormal_copulation1.08680590
59MP0000647_abnormal_sebaceous_gland1.07646921
60MP0008057_abnormal_DNA_replication1.06768309
61MP0009745_abnormal_behavioral_response1.06738978
62MP0005386_behavior/neurological_phenoty1.05674965
63MP0004924_abnormal_behavior1.05674965
64MP0001188_hyperpigmentation1.05397157
65MP0000955_abnormal_spinal_cord1.04961685
66MP0002752_abnormal_somatic_nervous1.04631782
67MP0000383_abnormal_hair_follicle1.03275737
68MP0002557_abnormal_social/conspecific_i1.02479927
69MP0002837_dystrophic_cardiac_calcinosis1.02076820
70MP0001177_atelectasis1.00458724
71MP0002184_abnormal_innervation1.00308009
72MP0001485_abnormal_pinna_reflex1.00104500
73MP0003718_maternal_effect0.98708644
74MP0002572_abnormal_emotion/affect_behav0.98404201
75MP0000427_abnormal_hair_cycle0.98351539
76MP0005195_abnormal_posterior_eye0.98151096
77MP0003861_abnormal_nervous_system0.97177824
78MP0002095_abnormal_skin_pigmentation0.96650046
79MP0005075_abnormal_melanosome_morpholog0.94040642
80MP0002734_abnormal_mechanical_nocicepti0.93857677
81MP0003755_abnormal_palate_morphology0.93424555
82MP0002067_abnormal_sensory_capabilities0.91913339
83MP0001324_abnormal_eye_pigmentation0.91395225
84MP0004043_abnormal_pH_regulation0.91090738
85MP0004142_abnormal_muscle_tone0.90731476
86MP0004147_increased_porphyrin_level0.89078628
87MP0002063_abnormal_learning/memory/cond0.87577774
88MP0003938_abnormal_ear_development0.87527461
89MP0005084_abnormal_gallbladder_morpholo0.87525599
90MP0002882_abnormal_neuron_morphology0.87493177
91MP0003635_abnormal_synaptic_transmissio0.85313956
92MP0001299_abnormal_eye_distance/0.85133331
93MP0000026_abnormal_inner_ear0.84920640
94MP0002928_abnormal_bile_duct0.84577553
95MP0004742_abnormal_vestibular_system0.83347019
96MP0002152_abnormal_brain_morphology0.82485882
97MP0008872_abnormal_physiological_respon0.82103283
98MP0003137_abnormal_impulse_conducting0.81163580
99MP0003011_delayed_dark_adaptation0.80617445
100MP0005171_absent_coat_pigmentation0.79124094

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.59150495
2True hermaphroditism (HP:0010459)3.56038222
3Pancreatic fibrosis (HP:0100732)3.26917321
4Medial flaring of the eyebrow (HP:0010747)3.19949429
5Nephronophthisis (HP:0000090)3.11509821
6Chronic hepatic failure (HP:0100626)3.10500564
7Molar tooth sign on MRI (HP:0002419)2.97460034
8Abnormality of midbrain morphology (HP:0002418)2.97460034
9Intestinal atresia (HP:0011100)2.94191908
10Gait imbalance (HP:0002141)2.90910675
11Congenital primary aphakia (HP:0007707)2.89047861
12Abnormality of the renal medulla (HP:0100957)2.84598013
13Abnormality of the labia minora (HP:0012880)2.82449914
14Colon cancer (HP:0003003)2.75524275
15Genital tract atresia (HP:0001827)2.71682256
16Vaginal atresia (HP:0000148)2.71422714
17Nephrogenic diabetes insipidus (HP:0009806)2.69281184
18Volvulus (HP:0002580)2.58750537
19Thyroiditis (HP:0100646)2.55028153
20Abnormality of the renal cortex (HP:0011035)2.52660892
21Tubulointerstitial nephritis (HP:0001970)2.37329490
22Hyperventilation (HP:0002883)2.25684189
23Poor coordination (HP:0002370)2.24279285
24Postaxial foot polydactyly (HP:0001830)2.21227097
25Postaxial hand polydactyly (HP:0001162)2.21135928
26Cystic liver disease (HP:0006706)2.20100214
27Renal cortical cysts (HP:0000803)2.13592448
28Septo-optic dysplasia (HP:0100842)2.12801230
29Methylmalonic acidemia (HP:0002912)2.10765379
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.10455267
31Abnormality of B cell number (HP:0010975)2.09304273
32B lymphocytopenia (HP:0010976)2.08997404
33Male pseudohermaphroditism (HP:0000037)2.08403055
34Drooling (HP:0002307)2.07804502
35Type 2 muscle fiber atrophy (HP:0003554)2.06105269
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.04709653
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.02838457
38Broad-based gait (HP:0002136)2.02827520
39Progressive inability to walk (HP:0002505)2.01726788
40Supernumerary spleens (HP:0009799)2.01346380
41Specific learning disability (HP:0001328)2.00281522
42Hyperglycinemia (HP:0002154)2.00074451
43Abnormality of the ileum (HP:0001549)1.99936136
44Oligodactyly (hands) (HP:0001180)1.98508218
45Sclerocornea (HP:0000647)1.95823388
46Thyroid-stimulating hormone excess (HP:0002925)1.95534403
47Anencephaly (HP:0002323)1.95450134
48Glioma (HP:0009733)1.95407936
49Bilateral microphthalmos (HP:0007633)1.93448614
50Abnormal hair whorl (HP:0010721)1.93437618
51Meckel diverticulum (HP:0002245)1.93298917
52Aplasia/Hypoplasia of the tongue (HP:0010295)1.93195682
53Cupped ear (HP:0000378)1.92481190
54Progressive cerebellar ataxia (HP:0002073)1.91284374
55Severe combined immunodeficiency (HP:0004430)1.90990841
56Abnormality of chromosome stability (HP:0003220)1.89987272
57Inability to walk (HP:0002540)1.89702840
58Renal hypoplasia (HP:0000089)1.88067833
59Congenital hepatic fibrosis (HP:0002612)1.87359854
60Optic nerve hypoplasia (HP:0000609)1.85160831
61Pendular nystagmus (HP:0012043)1.83161570
62Genetic anticipation (HP:0003743)1.82055186
63Narrow forehead (HP:0000341)1.81398903
64Excessive salivation (HP:0003781)1.81218549
65Preaxial hand polydactyly (HP:0001177)1.80437659
66Anophthalmia (HP:0000528)1.80311610
67Febrile seizures (HP:0002373)1.80080476
68Congenital stationary night blindness (HP:0007642)1.79704111
69Abnormal lung lobation (HP:0002101)1.79110918
70Astigmatism (HP:0000483)1.77929028
71Bile duct proliferation (HP:0001408)1.77792401
72Abnormal biliary tract physiology (HP:0012439)1.77792401
73Broad foot (HP:0001769)1.77430379
74Lissencephaly (HP:0001339)1.76976507
75Abolished electroretinogram (ERG) (HP:0000550)1.76255687
76Decreased muscle mass (HP:0003199)1.75151813
77Gastrointestinal atresia (HP:0002589)1.74633866
78Gonadotropin excess (HP:0000837)1.73468558
79Short tibia (HP:0005736)1.72692564
80Hepatoblastoma (HP:0002884)1.71620653
81Adactyly (HP:0009776)1.69029549
82Tubulointerstitial abnormality (HP:0001969)1.68373781
83Dandy-Walker malformation (HP:0001305)1.68244849
84Tubular atrophy (HP:0000092)1.66762279
85Micropenis (HP:0000054)1.66761312
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65938790
87Tented upper lip vermilion (HP:0010804)1.65702692
88Growth hormone deficiency (HP:0000824)1.65702083
89Medulloblastoma (HP:0002885)1.64643572
90Neoplasm of the oral cavity (HP:0100649)1.64368524
91Occipital encephalocele (HP:0002085)1.63760981
92Short foot (HP:0001773)1.62475312
93Absent speech (HP:0001344)1.61147027
94Patellar aplasia (HP:0006443)1.60848791
95Gaze-evoked nystagmus (HP:0000640)1.59452374
96Decreased testicular size (HP:0008734)1.59370980
97Aqueductal stenosis (HP:0002410)1.57752818
98Sloping forehead (HP:0000340)1.57679588
99Astrocytoma (HP:0009592)1.56251799
100Abnormality of the astrocytes (HP:0100707)1.56251799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.92399838
2WNK33.39307939
3FRK2.98875778
4PINK12.78744036
5BMPR1B2.77374763
6MAP3K42.73566561
7TRIM282.25281987
8BCR2.08587703
9NUAK12.04841826
10MKNK21.96741879
11MKNK11.92696020
12MAP2K71.90385863
13SRPK11.87775702
14MARK11.84412835
15ZAK1.80268382
16CASK1.79856450
17ERBB31.79376291
18MAPK131.70624488
19EPHA31.52156852
20ADRBK21.51255578
21INSRR1.50233871
22ACVR1B1.48241630
23DYRK21.44533707
24BRSK21.43989114
25TNIK1.41631786
26TAOK31.37650896
27AKT31.35699528
28PLK21.31695521
29PNCK1.31607696
30GRK11.31473933
31PLK41.24862000
32CSNK1G11.24699792
33DYRK31.22202442
34CSNK1G21.21699667
35PAK31.20499151
36EIF2AK31.18816065
37PLK31.15206151
38STK391.13669267
39CSNK1A1L1.11509709
40STK38L1.07734397
41EPHA41.05627305
42VRK11.04860577
43CSNK1G31.02623986
44WEE11.01463683
45TGFBR11.00613818
46TSSK60.99178587
47PBK0.97801622
48OXSR10.93784192
49CDK190.90624785
50FGFR20.85662816
51CDC70.84020388
52BRD40.81122555
53CCNB10.79838898
54PRKCE0.73163102
55WNK40.71569749
56SGK20.70718243
57LATS10.69570953
58NEK20.66699890
59MAP3K100.65437530
60RPS6KA40.65337563
61PIK3CA0.65316099
62MAP2K40.64766593
63NLK0.64662926
64NTRK20.63943028
65NEK10.62427084
66BCKDK0.62414853
67CAMKK20.62164350
68PRKCG0.61897223
69PKN10.61344427
70DYRK1A0.60762123
71STK30.57953375
72PLK10.57731163
73ATM0.57235648
74ATR0.56454323
75BUB10.56409562
76MINK10.56288611
77SGK4940.53958141
78SGK2230.53958141
79RPS6KA50.51737189
80TTK0.51234025
81TAF10.49635204
82FLT30.48849238
83CSNK1A10.46216022
84CDK30.45214555
85FER0.43024982
86NTRK30.42982973
87DYRK1B0.41943522
88ERBB20.41897411
89OBSCN0.41491009
90STK160.40985300
91TEC0.39485941
92PRKACB0.38430130
93FGFR10.38423952
94CSNK1D0.37381060
95DAPK20.37200690
96TIE10.34217533
97ADRBK10.33907141
98CAMK2A0.33880384
99PASK0.33774084
100YES10.30946033

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06611301
2Non-homologous end-joining_Homo sapiens_hsa034502.88597316
3Protein export_Homo sapiens_hsa030602.77538823
4Basal transcription factors_Homo sapiens_hsa030222.62939258
5Nicotine addiction_Homo sapiens_hsa050332.47845194
6Fanconi anemia pathway_Homo sapiens_hsa034602.44645157
7Propanoate metabolism_Homo sapiens_hsa006402.43112079
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41046930
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.31050392
10Homologous recombination_Homo sapiens_hsa034402.15263350
11Phototransduction_Homo sapiens_hsa047442.04436989
12Butanoate metabolism_Homo sapiens_hsa006501.99789735
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93144408
14Steroid biosynthesis_Homo sapiens_hsa001001.92333359
15RNA polymerase_Homo sapiens_hsa030201.85020614
16RNA degradation_Homo sapiens_hsa030181.83131579
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79949380
18Mismatch repair_Homo sapiens_hsa034301.73685626
19Selenocompound metabolism_Homo sapiens_hsa004501.72091981
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57395172
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49298574
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49021085
23Oxidative phosphorylation_Homo sapiens_hsa001901.46295146
24Taste transduction_Homo sapiens_hsa047421.45105053
25RNA transport_Homo sapiens_hsa030131.43621716
26Parkinsons disease_Homo sapiens_hsa050121.30156606
27Linoleic acid metabolism_Homo sapiens_hsa005911.28082836
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.26942921
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25325165
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22431594
31Hedgehog signaling pathway_Homo sapiens_hsa043401.22310730
32Nitrogen metabolism_Homo sapiens_hsa009101.16433456
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13733839
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13140713
35Caffeine metabolism_Homo sapiens_hsa002321.12989833
36Spliceosome_Homo sapiens_hsa030401.11858131
37Ether lipid metabolism_Homo sapiens_hsa005651.10970011
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08939226
39Fatty acid elongation_Homo sapiens_hsa000621.07519919
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06759122
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03708094
42Huntingtons disease_Homo sapiens_hsa050161.03187666
43Peroxisome_Homo sapiens_hsa041461.02863936
44GABAergic synapse_Homo sapiens_hsa047271.01832206
45Regulation of autophagy_Homo sapiens_hsa041401.01438861
46Basal cell carcinoma_Homo sapiens_hsa052170.97389607
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.97148668
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95478260
49Nucleotide excision repair_Homo sapiens_hsa034200.94519291
50Morphine addiction_Homo sapiens_hsa050320.94252628
51Alcoholism_Homo sapiens_hsa050340.92434393
52mRNA surveillance pathway_Homo sapiens_hsa030150.91080658
53Glutamatergic synapse_Homo sapiens_hsa047240.89741632
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89573006
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.89114742
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87571784
57Tryptophan metabolism_Homo sapiens_hsa003800.85644660
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84945780
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84448499
60Proteasome_Homo sapiens_hsa030500.83748553
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81701390
62Circadian entrainment_Homo sapiens_hsa047130.79348214
63Dopaminergic synapse_Homo sapiens_hsa047280.78487454
64Fatty acid metabolism_Homo sapiens_hsa012120.77540995
65Olfactory transduction_Homo sapiens_hsa047400.76497596
66Purine metabolism_Homo sapiens_hsa002300.75763590
67Oocyte meiosis_Homo sapiens_hsa041140.73319165
68One carbon pool by folate_Homo sapiens_hsa006700.72230090
69Cell cycle_Homo sapiens_hsa041100.72159671
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.71643183
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69030884
72Serotonergic synapse_Homo sapiens_hsa047260.67551164
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67057949
74TGF-beta signaling pathway_Homo sapiens_hsa043500.66735001
75Cocaine addiction_Homo sapiens_hsa050300.66499607
76Chemical carcinogenesis_Homo sapiens_hsa052040.66255917
77Hippo signaling pathway_Homo sapiens_hsa043900.65714886
78Circadian rhythm_Homo sapiens_hsa047100.65283605
79Base excision repair_Homo sapiens_hsa034100.65046896
80Retinol metabolism_Homo sapiens_hsa008300.63596997
81Lysine degradation_Homo sapiens_hsa003100.62691422
82beta-Alanine metabolism_Homo sapiens_hsa004100.61510292
83Amphetamine addiction_Homo sapiens_hsa050310.61439549
84Axon guidance_Homo sapiens_hsa043600.60299825
85Alzheimers disease_Homo sapiens_hsa050100.53691809
86Systemic lupus erythematosus_Homo sapiens_hsa053220.51952734
87p53 signaling pathway_Homo sapiens_hsa041150.51763610
88Wnt signaling pathway_Homo sapiens_hsa043100.51349164
89Metabolic pathways_Homo sapiens_hsa011000.51134207
90Long-term depression_Homo sapiens_hsa047300.49605962
91Pyrimidine metabolism_Homo sapiens_hsa002400.49504153
92Pyruvate metabolism_Homo sapiens_hsa006200.46793230
93Vitamin digestion and absorption_Homo sapiens_hsa049770.46383458
94Cardiac muscle contraction_Homo sapiens_hsa042600.46107639
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45876565
96Collecting duct acid secretion_Homo sapiens_hsa049660.44874056
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44298388
98Insulin secretion_Homo sapiens_hsa049110.40918074
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36842079
100Fatty acid degradation_Homo sapiens_hsa000710.36433700

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