ZNF256

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)6.65743650
2protein deneddylation (GO:0000338)6.10007526
3protein K11-linked deubiquitination (GO:0035871)5.86762048
4DNA replication-dependent nucleosome assembly (GO:0006335)5.39228401
5DNA replication-dependent nucleosome organization (GO:0034723)5.39228401
6regulation of mitotic spindle checkpoint (GO:1903504)5.12537179
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)5.12537179
8protein-chromophore linkage (GO:0018298)4.63570300
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.16220820
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.99330813
11postreplication repair (GO:0006301)3.98578524
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.97936386
13negative regulation of translation, ncRNA-mediated (GO:0040033)3.97936386
14regulation of translation, ncRNA-mediated (GO:0045974)3.97936386
15non-recombinational repair (GO:0000726)3.97545203
16double-strand break repair via nonhomologous end joining (GO:0006303)3.97545203
17platelet dense granule organization (GO:0060155)3.86261132
18pyrimidine nucleotide catabolic process (GO:0006244)3.85922950
19phosphorylated carbohydrate dephosphorylation (GO:0046838)3.85872008
20inositol phosphate dephosphorylation (GO:0046855)3.85872008
21L-serine metabolic process (GO:0006563)3.81680782
22somatic hypermutation of immunoglobulin genes (GO:0016446)3.80701480
23somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80701480
24chromatin remodeling at centromere (GO:0031055)3.73110192
25mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.72737798
26positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.72737798
27protein localization to kinetochore (GO:0034501)3.71308906
28histone H2A ubiquitination (GO:0033522)3.67464112
29regulation of spindle checkpoint (GO:0090231)3.63200607
30DNA replication-independent nucleosome organization (GO:0034724)3.55440935
31DNA replication-independent nucleosome assembly (GO:0006336)3.55440935
32negative regulation of cell cycle G2/M phase transition (GO:1902750)3.54515981
33mitotic metaphase plate congression (GO:0007080)3.46662112
34CENP-A containing nucleosome assembly (GO:0034080)3.46552882
35translesion synthesis (GO:0019985)3.44249312
36vitamin transmembrane transport (GO:0035461)3.44123277
37DNA double-strand break processing (GO:0000729)3.43422855
38protein localization to chromosome, centromeric region (GO:0071459)3.41878639
39replication fork processing (GO:0031297)3.39672701
40inositol phosphate catabolic process (GO:0071545)3.38482437
41DNA ligation (GO:0006266)3.36962238
42microtubule depolymerization (GO:0007019)3.35937701
43histone H3-K9 methylation (GO:0051567)3.33029648
44behavioral response to nicotine (GO:0035095)3.24123996
45protein polyglutamylation (GO:0018095)3.23797109
46mismatch repair (GO:0006298)3.23129922
47pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.21343208
48metaphase plate congression (GO:0051310)3.18223207
49phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.13968556
50histone exchange (GO:0043486)3.12302379
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08591816
52kinetochore assembly (GO:0051382)3.05961713
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.03045848
54morphogenesis of an endothelium (GO:0003159)2.98404214
55endothelial tube morphogenesis (GO:0061154)2.98404214
56artery development (GO:0060840)2.96255715
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95769233
58kinetochore organization (GO:0051383)2.94204424
59attachment of spindle microtubules to kinetochore (GO:0008608)2.93231492
60synapsis (GO:0007129)2.92678990
61negative regulation of DNA recombination (GO:0045910)2.92632489
62histone H2A monoubiquitination (GO:0035518)2.92182896
63response to X-ray (GO:0010165)2.89317873
64pyrimidine dimer repair (GO:0006290)2.86743477
65protein targeting to Golgi (GO:0000042)2.86683366
66protein K11-linked ubiquitination (GO:0070979)2.84643421
67negative regulation of meiosis (GO:0045835)2.83915485
68microtubule nucleation (GO:0007020)2.83714215
69spindle checkpoint (GO:0031577)2.82088116
70IMP biosynthetic process (GO:0006188)2.82035110
71mitochondrial RNA metabolic process (GO:0000959)2.80128726
72establishment of protein localization to Golgi (GO:0072600)2.79177680
73histone H3-K9 modification (GO:0061647)2.75445363
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75112926
75regulation of meiosis I (GO:0060631)2.74152170
76DNA replication checkpoint (GO:0000076)2.73631310
77mannosylation (GO:0097502)2.73079231
78resolution of meiotic recombination intermediates (GO:0000712)2.72578049
79protein modification by small protein removal (GO:0070646)2.72419432
80organelle disassembly (GO:1903008)2.71498015
81piRNA metabolic process (GO:0034587)2.70308886
82mitotic sister chromatid cohesion (GO:0007064)2.68769890
83DNA strand elongation involved in DNA replication (GO:0006271)2.66447877
84neuron fate determination (GO:0048664)2.66223028
85anterograde synaptic vesicle transport (GO:0048490)2.66088087
86chromatin assembly or disassembly (GO:0006333)2.65198948
87negative regulation of mitotic sister chromatid separation (GO:2000816)2.64381371
88negative regulation of sister chromatid segregation (GO:0033046)2.64381371
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64381371
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64381371
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64381371
92negative regulation of chromosome segregation (GO:0051985)2.63604764
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63574311
94chromatin assembly (GO:0031497)2.62319732
95inositol metabolic process (GO:0006020)2.61518433
96establishment of integrated proviral latency (GO:0075713)2.59680674
97response to misfolded protein (GO:0051788)2.56837872
98photoreceptor cell maintenance (GO:0045494)2.56821405
99mitotic spindle checkpoint (GO:0071174)2.55962648
100regulation of vesicle fusion (GO:0031338)2.55815857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.79352705
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.88661556
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.50514651
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.43286849
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43188364
6VDR_22108803_ChIP-Seq_LS180_Human3.39531800
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.25944357
8* EST1_17652178_ChIP-ChIP_JURKAT_Human3.12004593
9IGF1R_20145208_ChIP-Seq_DFB_Human3.05202168
10ZNF274_21170338_ChIP-Seq_K562_Hela2.84879701
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79919205
12* NOTCH1_21737748_ChIP-Seq_TLL_Human2.77756940
13* TP63_19390658_ChIP-ChIP_HaCaT_Human2.55918201
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47740920
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.38029905
16ELK1_19687146_ChIP-ChIP_HELA_Human2.37861462
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30693694
18FUS_26573619_Chip-Seq_HEK293_Human2.30296927
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28961142
20FOXP3_21729870_ChIP-Seq_TREG_Human2.22773495
21VDR_23849224_ChIP-Seq_CD4+_Human2.19498809
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14536911
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02522670
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93285479
25EZH2_22144423_ChIP-Seq_EOC_Human1.90868251
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89623730
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86688149
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80208078
29IRF1_19129219_ChIP-ChIP_H3396_Human1.70523021
30EWS_26573619_Chip-Seq_HEK293_Human1.70069102
31* ETS1_20019798_ChIP-Seq_JURKAT_Human1.68642334
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.65808097
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.64776239
34* MYC_18940864_ChIP-ChIP_HL60_Human1.63962890
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63866696
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60393955
37P300_19829295_ChIP-Seq_ESCs_Human1.59527364
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.58432631
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56124040
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56002165
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55562370
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53592686
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50837485
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48653430
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44929630
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42949913
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.41146233
48TTF2_22483619_ChIP-Seq_HELA_Human1.41089582
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40551523
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38327755
51* GABP_19822575_ChIP-Seq_HepG2_Human1.37713165
52GBX2_23144817_ChIP-Seq_PC3_Human1.36064431
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34242407
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30270655
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28380547
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26693912
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25732312
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25732312
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25037185
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20863928
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.20853320
62NANOG_19829295_ChIP-Seq_ESCs_Human1.19717290
63SOX2_19829295_ChIP-Seq_ESCs_Human1.19717290
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19713664
65AR_21909140_ChIP-Seq_LNCAP_Human1.19070093
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18322858
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17252585
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17009881
69KDM5A_27292631_Chip-Seq_BREAST_Human1.16110539
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15283391
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13440442
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11386170
73RNF2_27304074_Chip-Seq_NSC_Mouse1.09182437
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08402007
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08402007
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08402007
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06707529
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05740199
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05412136
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04685138
81TP53_22573176_ChIP-Seq_HFKS_Human1.04134491
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03496625
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03151764
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01533734
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99980078
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98640506
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.98385538
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95914306
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95843550
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95739554
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94959412
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94595263
93YY1_21170310_ChIP-Seq_MESCs_Mouse0.94205592
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92851815
95MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91303606
96XRN2_22483619_ChIP-Seq_HELA_Human0.87743223
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86623987
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84727336
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82945810
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82925048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.73727538
2MP0005083_abnormal_biliary_tract4.83000104
3MP0002638_abnormal_pupillary_reflex4.56676592
4MP0008057_abnormal_DNA_replication3.38161428
5MP0010094_abnormal_chromosome_stability3.13801109
6MP0001529_abnormal_vocalization2.98903622
7MP0008877_abnormal_DNA_methylation2.78706418
8MP0006072_abnormal_retinal_apoptosis2.75045416
9MP0005084_abnormal_gallbladder_morpholo2.74242463
10MP0003693_abnormal_embryo_hatching2.72892989
11MP0008058_abnormal_DNA_repair2.62458630
12MP0005253_abnormal_eye_physiology2.59305924
13MP0003890_abnormal_embryonic-extraembry2.44138018
14MP0003718_maternal_effect2.30619303
15MP0005085_abnormal_gallbladder_physiolo2.28015775
16MP0003122_maternal_imprinting2.27588805
17MP0000569_abnormal_digit_pigmentation2.11154475
18MP0003567_abnormal_fetal_cardiomyocyte1.97700188
19MP0003121_genomic_imprinting1.95522756
20MP0004957_abnormal_blastocyst_morpholog1.94912562
21MP0006292_abnormal_olfactory_placode1.87811514
22MP0008932_abnormal_embryonic_tissue1.86661622
23MP0005365_abnormal_bile_salt1.83598533
24MP0003111_abnormal_nucleus_morphology1.81134555
25MP0002102_abnormal_ear_morphology1.79600579
26MP0001764_abnormal_homeostasis1.73397181
27MP0002736_abnormal_nociception_after1.73164793
28MP0003077_abnormal_cell_cycle1.73109592
29MP0001293_anophthalmia1.71615534
30MP0003787_abnormal_imprinting1.61926529
31MP0003943_abnormal_hepatobiliary_system1.54678783
32MP0005499_abnormal_olfactory_system1.48829025
33MP0005394_taste/olfaction_phenotype1.48829025
34MP0009672_abnormal_birth_weight1.48296640
35MP0002928_abnormal_bile_duct1.45774698
36MP0005391_vision/eye_phenotype1.44966821
37MP0008789_abnormal_olfactory_epithelium1.39937201
38MP0001984_abnormal_olfaction1.38595960
39MP0002837_dystrophic_cardiac_calcinosis1.38200491
40MP0002751_abnormal_autonomic_nervous1.27507726
41MP0000465_gastrointestinal_hemorrhage1.20099043
42MP0001730_embryonic_growth_arrest1.15319599
43MP0003941_abnormal_skin_development1.09636332
44MP0002160_abnormal_reproductive_system1.08747608
45MP0003136_yellow_coat_color1.08425750
46MP0004133_heterotaxia1.07453432
47MP0005380_embryogenesis_phenotype1.03748915
48MP0001672_abnormal_embryogenesis/_devel1.03748915
49MP0008775_abnormal_heart_ventricle0.94631905
50MP0009703_decreased_birth_body0.94538003
51MP0000778_abnormal_nervous_system0.94028615
52MP0008007_abnormal_cellular_replicative0.93942811
53MP0000372_irregular_coat_pigmentation0.93633605
54MP0001286_abnormal_eye_development0.93297733
55MP0003221_abnormal_cardiomyocyte_apopto0.92502161
56MP0005551_abnormal_eye_electrophysiolog0.89964020
57MP0002210_abnormal_sex_determination0.89869639
58MP0001929_abnormal_gametogenesis0.86173163
59MP0002084_abnormal_developmental_patter0.85126212
60MP0002088_abnormal_embryonic_growth/wei0.83053935
61MP0001119_abnormal_female_reproductive0.82413913
62MP0001697_abnormal_embryo_size0.82248953
63MP0001502_abnormal_circadian_rhythm0.82217809
64MP0002085_abnormal_embryonic_tissue0.81898804
65MP0006035_abnormal_mitochondrial_morpho0.80615632
66MP0005195_abnormal_posterior_eye0.80281707
67MP0003984_embryonic_growth_retardation0.79284553
68MP0002938_white_spotting0.78936559
69MP0000350_abnormal_cell_proliferation0.78435432
70MP0000653_abnormal_sex_gland0.77452885
71MP0001145_abnormal_male_reproductive0.76524339
72MP0002735_abnormal_chemical_nociception0.76363824
73MP0002752_abnormal_somatic_nervous0.74338121
74MP0002233_abnormal_nose_morphology0.72434822
75MP0006276_abnormal_autonomic_nervous0.71757065
76MP0005395_other_phenotype0.70771997
77MP0001968_abnormal_touch/_nociception0.70748516
78MP0003937_abnormal_limbs/digits/tail_de0.70091836
79MP0005379_endocrine/exocrine_gland_phen0.69788113
80MP0002653_abnormal_ependyma_morphology0.68845127
81MP0004197_abnormal_fetal_growth/weight/0.66920154
82MP0000631_abnormal_neuroendocrine_gland0.65600871
83MP0003119_abnormal_digestive_system0.64713991
84MP0002277_abnormal_respiratory_mucosa0.64081865
85MP0003123_paternal_imprinting0.63796446
86MP0003861_abnormal_nervous_system0.63684599
87MP0009765_abnormal_xenobiotic_induced0.63351471
88MP0001986_abnormal_taste_sensitivity0.63043618
89MP0005075_abnormal_melanosome_morpholog0.62909822
90MP0002138_abnormal_hepatobiliary_system0.61398598
91MP0000049_abnormal_middle_ear0.61243711
92MP0002009_preneoplasia0.60996414
93MP0005389_reproductive_system_phenotype0.59829371
94MP0004859_abnormal_synaptic_plasticity0.58117179
95MP0002080_prenatal_lethality0.57536411
96MP0003699_abnormal_female_reproductive0.57310718
97MP0002234_abnormal_pharynx_morphology0.57277299
98MP0003724_increased_susceptibility_to0.56688139
99MP0001919_abnormal_reproductive_system0.55365300
100MP0000383_abnormal_hair_follicle0.53811203

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)6.34875138
2Colon cancer (HP:0003003)4.40981075
3Septo-optic dysplasia (HP:0100842)4.03685961
4Chronic hepatic failure (HP:0100626)3.68070989
5Volvulus (HP:0002580)3.47382303
6Atrophy/Degeneration involving motor neurons (HP:0007373)3.45511634
7Retinal dysplasia (HP:0007973)3.39490622
8Amyotrophic lateral sclerosis (HP:0007354)3.29719556
9Abnormality of the anterior horn cell (HP:0006802)3.25647519
10Degeneration of anterior horn cells (HP:0002398)3.25647519
11Type II lissencephaly (HP:0007260)3.18593755
12Abnormality of the labia minora (HP:0012880)3.13037249
13Intestinal atresia (HP:0011100)3.12044421
14Medulloblastoma (HP:0002885)3.01828528
15Abnormality of the lower motor neuron (HP:0002366)3.00797908
16Hypoplastic pelvis (HP:0008839)3.00258634
17Rhabdomyosarcoma (HP:0002859)2.76968132
18Rectovaginal fistula (HP:0000143)2.69997460
19Rectal fistula (HP:0100590)2.69997460
20Abnormality of the ileum (HP:0001549)2.61315513
21Optic nerve coloboma (HP:0000588)2.57508964
22Ependymoma (HP:0002888)2.55294220
23Upper motor neuron abnormality (HP:0002127)2.54302216
24Azoospermia (HP:0000027)2.54160633
25Abnormality of chromosome stability (HP:0003220)2.51951549
26Skull defect (HP:0001362)2.51386449
27Meckel diverticulum (HP:0002245)2.46388447
28Abnormality of the corticospinal tract (HP:0002492)2.38074492
29Pancreatic cysts (HP:0001737)2.31204487
30Gonadotropin excess (HP:0000837)2.30629171
31Molar tooth sign on MRI (HP:0002419)2.28629058
32Abnormality of midbrain morphology (HP:0002418)2.28629058
33Intestinal fistula (HP:0100819)2.23677992
34Abnormal spermatogenesis (HP:0008669)2.23276645
35Hyperglycinemia (HP:0002154)2.23155708
36Oligodactyly (hands) (HP:0001180)2.21436701
37Reticulocytopenia (HP:0001896)2.20399599
38Adactyly (HP:0009776)2.20277133
39Nephronophthisis (HP:0000090)2.19535343
40Progressive inability to walk (HP:0002505)2.18372456
41Spastic diplegia (HP:0001264)2.18021748
42Vaginal fistula (HP:0004320)2.16379857
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.15177624
44True hermaphroditism (HP:0010459)2.14902969
45Patellar aplasia (HP:0006443)2.14277697
46Abnormal lung lobation (HP:0002101)2.13402431
47Pancreatic fibrosis (HP:0100732)2.11480661
48Optic nerve hypoplasia (HP:0000609)2.09279499
49Abnormality of the septum pellucidum (HP:0007375)2.08568498
50Lissencephaly (HP:0001339)2.07597139
51Aplasia/Hypoplasia of the patella (HP:0006498)2.05980580
52Absent septum pellucidum (HP:0001331)2.03992435
53Agnosia (HP:0010524)2.03737573
54Ectopic kidney (HP:0000086)2.03410413
55Dandy-Walker malformation (HP:0001305)2.00264751
56Nephroblastoma (Wilms tumor) (HP:0002667)1.99760034
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98543227
58Absent thumb (HP:0009777)1.97920791
59Glioma (HP:0009733)1.97910149
60Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97709974
61Gastrointestinal atresia (HP:0002589)1.93706428
62Aplasia/Hypoplasia of the tibia (HP:0005772)1.92682549
63Abnormality of the antihelix (HP:0009738)1.92432546
64Supernumerary spleens (HP:0009799)1.91594084
65Short tibia (HP:0005736)1.87831547
66Type I transferrin isoform profile (HP:0003642)1.85641952
67Carpal bone hypoplasia (HP:0001498)1.85387644
68Neoplasm of striated muscle (HP:0009728)1.85251926
69Micropenis (HP:0000054)1.85188491
70Fair hair (HP:0002286)1.84425428
71Pseudobulbar signs (HP:0002200)1.82278922
72Exercise-induced muscle cramps (HP:0003710)1.81861030
73Sloping forehead (HP:0000340)1.81325797
74Tetraplegia (HP:0002445)1.80919222
75Aplasia/Hypoplasia of the sternum (HP:0006714)1.80769228
76Embryonal renal neoplasm (HP:0011794)1.79850409
77Stenosis of the external auditory canal (HP:0000402)1.79309157
78Triphalangeal thumb (HP:0001199)1.78812118
79Acute lymphatic leukemia (HP:0006721)1.77256122
80Urethral obstruction (HP:0000796)1.77205220
81Neoplasm of the oral cavity (HP:0100649)1.76402181
82Drooling (HP:0002307)1.76207861
832-3 toe syndactyly (HP:0004691)1.75370192
84Abnormality of the duodenum (HP:0002246)1.73450578
85Inability to walk (HP:0002540)1.72918457
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72806618
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71344909
88Abnormal protein N-linked glycosylation (HP:0012347)1.71344909
89Abnormal protein glycosylation (HP:0012346)1.71344909
90Abnormal glycosylation (HP:0012345)1.71344909
91Methylmalonic acidemia (HP:0002912)1.71070574
92Abnormality of the renal medulla (HP:0100957)1.70679942
93Renal cortical cysts (HP:0000803)1.68263116
94Postaxial hand polydactyly (HP:0001162)1.66320601
95Pachygyria (HP:0001302)1.66223010
96Abnormality of the astrocytes (HP:0100707)1.65809520
97Astrocytoma (HP:0009592)1.65809520
98Growth hormone deficiency (HP:0000824)1.65178391
99Postaxial foot polydactyly (HP:0001830)1.64671709
100Small intestinal stenosis (HP:0012848)1.62899756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME17.28680025
2CDC72.68183247
3SRPK12.53430845
4TRIM282.42204537
5BUB12.21897018
6NUAK12.18911417
7MKNK12.10182222
8PASK2.06955443
9CDK192.04925803
10EIF2AK32.01552307
11MAP3K101.84279173
12MKNK21.75833335
13ERBB31.71952770
14TTK1.70119322
15TAOK31.65163071
16ZAK1.64177496
17BRSK21.61166921
18BRD41.48925601
19PLK41.46186230
20PLK31.44353196
21TSSK61.44308846
22PINK11.42280764
23CAMK1D1.39696058
24VRK11.37947712
25STK38L1.37443469
26MAPK151.37152304
27DYRK21.31587064
28DYRK31.30223238
29BCR1.29440019
30CAMK1G1.28129968
31CSNK1G21.24710172
32WNK31.21323348
33SIK31.19766891
34WEE11.16598649
35PLK11.13679068
36PKN11.13543668
37MAP3K41.12928023
38BCKDK1.10646876
39LATS11.10215755
40CHEK21.06280398
41EIF2AK21.05978279
42CSNK1G31.04570568
43MAPK131.03489585
44STK161.02877478
45CSNK1G11.01483584
46NEK10.99859587
47AURKA0.96912779
48AURKB0.93502592
49ATR0.88969690
50PRKD20.87458377
51TAF10.83033093
52CHEK10.81820338
53CSNK1A1L0.81765567
54FLT30.80122585
55IRAK20.78837809
56EIF2AK10.78585677
57ATM0.71322692
58PIM10.71173341
59NEK60.70990378
60CDK10.70388675
61MAP2K70.70192868
62PBK0.69405935
63PIK3CG0.67993527
64RPS6KA40.65281832
65TGFBR10.65205087
66PIK3CA0.64609327
67PAK30.64087781
68CDK90.58984432
69PNCK0.57389344
70IRAK10.55739558
71STK30.55546816
72CDK60.55280111
73WNK10.54544327
74IKBKE0.54194268
75CDK20.53668661
76CDK30.52624870
77PRKCQ0.52546808
78MARK30.49668042
79CAMK10.48634725
80BRSK10.47051602
81CDK70.46809876
82FRK0.46716222
83OBSCN0.45694977
84BMPR1B0.42425134
85MAP3K70.41315423
86TEC0.40796100
87CSNK2A10.39371867
88TAOK10.37552357
89ERBB40.37435259
90CAMK40.36486992
91DYRK1B0.36348472
92TNIK0.34725340
93TLK10.34253017
94MARK10.33902638
95NTRK20.33864416
96RPS6KA10.32535542
97EGFR0.32180035
98PRKAA10.31727818
99TIE10.31422452
100STK40.31046510

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.27987351
2Mismatch repair_Homo sapiens_hsa034303.26824556
3Non-homologous end-joining_Homo sapiens_hsa034503.25994366
4Basal transcription factors_Homo sapiens_hsa030223.14985789
5DNA replication_Homo sapiens_hsa030303.09055361
6RNA degradation_Homo sapiens_hsa030183.08236341
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91128251
8Selenocompound metabolism_Homo sapiens_hsa004502.90591270
9RNA transport_Homo sapiens_hsa030132.78998199
10Homologous recombination_Homo sapiens_hsa034402.75785979
11Base excision repair_Homo sapiens_hsa034102.68338254
12Cell cycle_Homo sapiens_hsa041102.58007793
13RNA polymerase_Homo sapiens_hsa030202.57078178
14Ribosome_Homo sapiens_hsa030102.54009385
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19756798
16Spliceosome_Homo sapiens_hsa030402.18626124
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03535252
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01746712
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81342688
20Nucleotide excision repair_Homo sapiens_hsa034201.77620033
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74389269
22One carbon pool by folate_Homo sapiens_hsa006701.69992106
23mRNA surveillance pathway_Homo sapiens_hsa030151.69525770
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64299269
25Pyrimidine metabolism_Homo sapiens_hsa002401.63794473
26Regulation of autophagy_Homo sapiens_hsa041401.53888906
27Lysine degradation_Homo sapiens_hsa003101.47420304
28Inositol phosphate metabolism_Homo sapiens_hsa005621.41410367
29p53 signaling pathway_Homo sapiens_hsa041151.36864251
30Oocyte meiosis_Homo sapiens_hsa041141.29270074
31Purine metabolism_Homo sapiens_hsa002301.29076295
32Steroid biosynthesis_Homo sapiens_hsa001001.23218734
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.19613781
34Proteasome_Homo sapiens_hsa030501.08737729
35Pyruvate metabolism_Homo sapiens_hsa006201.03029522
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02269850
37Propanoate metabolism_Homo sapiens_hsa006401.01866807
38Nicotine addiction_Homo sapiens_hsa050330.99296997
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98898534
40Phototransduction_Homo sapiens_hsa047440.97296926
41Protein export_Homo sapiens_hsa030600.96331444
42Epstein-Barr virus infection_Homo sapiens_hsa051690.89009931
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.85958408
44Linoleic acid metabolism_Homo sapiens_hsa005910.84532150
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84024322
46Retinol metabolism_Homo sapiens_hsa008300.81553496
47Parkinsons disease_Homo sapiens_hsa050120.75986512
48Biosynthesis of amino acids_Homo sapiens_hsa012300.74744294
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72474532
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70075042
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69928843
52Huntingtons disease_Homo sapiens_hsa050160.68628427
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67980272
54Arachidonic acid metabolism_Homo sapiens_hsa005900.67365310
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63887565
56Glutathione metabolism_Homo sapiens_hsa004800.61649600
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60528202
58Vitamin digestion and absorption_Homo sapiens_hsa049770.60351812
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60301425
60Oxidative phosphorylation_Homo sapiens_hsa001900.59163770
61Metabolic pathways_Homo sapiens_hsa011000.58094366
62Fatty acid elongation_Homo sapiens_hsa000620.56914533
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.56250666
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55447462
65Notch signaling pathway_Homo sapiens_hsa043300.54828873
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54774998
67Fatty acid metabolism_Homo sapiens_hsa012120.54764453
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54001999
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52878102
70Carbon metabolism_Homo sapiens_hsa012000.52018369
71Basal cell carcinoma_Homo sapiens_hsa052170.51720126
72Viral carcinogenesis_Homo sapiens_hsa052030.50537145
73Hippo signaling pathway_Homo sapiens_hsa043900.48994347
74Olfactory transduction_Homo sapiens_hsa047400.48098398
75Ether lipid metabolism_Homo sapiens_hsa005650.43562533
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42564163
77Circadian rhythm_Homo sapiens_hsa047100.41424880
78Taste transduction_Homo sapiens_hsa047420.39004321
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37314604
80Hedgehog signaling pathway_Homo sapiens_hsa043400.35755339
81Wnt signaling pathway_Homo sapiens_hsa043100.35585700
82Fatty acid biosynthesis_Homo sapiens_hsa000610.35102784
83Cardiac muscle contraction_Homo sapiens_hsa042600.32445562
84Primary immunodeficiency_Homo sapiens_hsa053400.32431968
85TGF-beta signaling pathway_Homo sapiens_hsa043500.30725059
86Measles_Homo sapiens_hsa051620.29917258
87Arginine and proline metabolism_Homo sapiens_hsa003300.29368781
88Systemic lupus erythematosus_Homo sapiens_hsa053220.26416844
89MicroRNAs in cancer_Homo sapiens_hsa052060.25908482
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25006202
91Herpes simplex infection_Homo sapiens_hsa051680.24662362
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22454944
93Morphine addiction_Homo sapiens_hsa050320.21307886
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20291895
95Colorectal cancer_Homo sapiens_hsa052100.19166017
96Butanoate metabolism_Homo sapiens_hsa006500.15515795
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15159735
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15070282
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13323379
100Pentose phosphate pathway_Homo sapiens_hsa000300.12850383

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