ZNF257

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose catabolic process (GO:0042355)4.43203438
2fucose catabolic process (GO:0019317)4.43203438
3L-fucose metabolic process (GO:0042354)4.43203438
4synapsis (GO:0007129)4.12950899
5DNA deamination (GO:0045006)4.02959888
6behavioral response to nicotine (GO:0035095)3.86842083
7piRNA metabolic process (GO:0034587)3.84022799
8regulation of meiosis I (GO:0060631)3.77977563
9protein-cofactor linkage (GO:0018065)3.76196504
10protein complex biogenesis (GO:0070271)3.68507660
11somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65547963
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.65547963
13indole-containing compound catabolic process (GO:0042436)3.54913110
14indolalkylamine catabolic process (GO:0046218)3.54913110
15tryptophan catabolic process (GO:0006569)3.54913110
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52541174
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.52541174
18NADH dehydrogenase complex assembly (GO:0010257)3.52541174
19mitochondrial respiratory chain complex assembly (GO:0033108)3.44662298
20replication fork processing (GO:0031297)3.34894183
21rRNA catabolic process (GO:0016075)3.34104762
22respiratory chain complex IV assembly (GO:0008535)3.30105963
23male meiosis I (GO:0007141)3.27034120
24pseudouridine synthesis (GO:0001522)3.25061330
25water-soluble vitamin biosynthetic process (GO:0042364)3.23344811
26cytochrome complex assembly (GO:0017004)3.17671505
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.13291189
28tryptophan metabolic process (GO:0006568)3.12172878
29reciprocal meiotic recombination (GO:0007131)3.11014144
30reciprocal DNA recombination (GO:0035825)3.11014144
31response to pheromone (GO:0019236)3.10967517
32kidney morphogenesis (GO:0060993)3.08556880
33DNA methylation involved in gamete generation (GO:0043046)3.08430629
34indolalkylamine metabolic process (GO:0006586)3.06671230
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05864268
36neural tube formation (GO:0001841)3.03855982
37somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03262035
38somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03262035
39isotype switching (GO:0045190)3.03262035
40DNA double-strand break processing (GO:0000729)3.02142901
41kynurenine metabolic process (GO:0070189)3.01690634
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.00672234
43proteasome assembly (GO:0043248)2.99987793
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99704826
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99704826
46intra-S DNA damage checkpoint (GO:0031573)2.97512267
47preassembly of GPI anchor in ER membrane (GO:0016254)2.94846462
48mannosylation (GO:0097502)2.91367917
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90131836
50meiotic chromosome segregation (GO:0045132)2.89138582
51recombinational repair (GO:0000725)2.88910003
52double-strand break repair via homologous recombination (GO:0000724)2.86317460
53phosphatidylinositol acyl-chain remodeling (GO:0036149)2.81018809
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79959434
55platelet dense granule organization (GO:0060155)2.79896569
56resolution of meiotic recombination intermediates (GO:0000712)2.78438822
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77608193
58DNA catabolic process, exonucleolytic (GO:0000738)2.74564238
59rRNA modification (GO:0000154)2.73978287
60protein K11-linked deubiquitination (GO:0035871)2.71725973
61male meiosis (GO:0007140)2.67648139
62meiosis I (GO:0007127)2.67588173
63centriole replication (GO:0007099)2.65409736
64protein polyglutamylation (GO:0018095)2.64011174
65negative regulation of telomere maintenance (GO:0032205)2.63131064
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62906005
67S-adenosylmethionine metabolic process (GO:0046500)2.61379384
68cellular ketone body metabolic process (GO:0046950)2.60240068
69behavioral response to ethanol (GO:0048149)2.58777720
70rRNA methylation (GO:0031167)2.58736946
71axoneme assembly (GO:0035082)2.58082654
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57056996
73dopamine transport (GO:0015872)2.56448226
74protein neddylation (GO:0045116)2.55276243
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55272655
76photoreceptor cell maintenance (GO:0045494)2.54789713
77detection of light stimulus involved in sensory perception (GO:0050962)2.54592464
78detection of light stimulus involved in visual perception (GO:0050908)2.54592464
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.54362886
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.50627128
81ATP synthesis coupled proton transport (GO:0015986)2.50627128
82nonmotile primary cilium assembly (GO:0035058)2.50292785
83multicellular organism reproduction (GO:0032504)2.48609205
84somite rostral/caudal axis specification (GO:0032525)2.48306552
85inositol phosphate catabolic process (GO:0071545)2.47674897
86positive regulation of prostaglandin secretion (GO:0032308)2.46910693
87somatic diversification of immunoglobulins (GO:0016445)2.46500831
88regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46257830
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45942006
90regulation of mesoderm development (GO:2000380)2.45858233
91tRNA processing (GO:0008033)2.45638951
92DNA replication checkpoint (GO:0000076)2.45456370
93retinal cone cell development (GO:0046549)2.42299324
94cornea development in camera-type eye (GO:0061303)2.41068101
95positive regulation of meiotic cell cycle (GO:0051446)2.40316359
96positive regulation of meiosis (GO:0045836)2.40186090
97regulation of mitotic spindle checkpoint (GO:1903504)2.39478853
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39478853
99DNA demethylation (GO:0080111)2.39475664
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38392179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.46165596
2VDR_22108803_ChIP-Seq_LS180_Human3.14709673
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03009793
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77264978
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.67237638
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.65742303
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59937007
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52534723
9EWS_26573619_Chip-Seq_HEK293_Human2.42809172
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.34661453
11IGF1R_20145208_ChIP-Seq_DFB_Human2.30206887
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.28300526
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24208153
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19863585
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15297666
16FUS_26573619_Chip-Seq_HEK293_Human2.10931961
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.10611448
18TAF15_26573619_Chip-Seq_HEK293_Human2.06895638
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04407994
20VDR_23849224_ChIP-Seq_CD4+_Human2.00293382
21GBX2_23144817_ChIP-Seq_PC3_Human1.99889794
22IRF1_19129219_ChIP-ChIP_H3396_Human1.89916217
23ER_23166858_ChIP-Seq_MCF-7_Human1.87055952
24ELK1_19687146_ChIP-ChIP_HELA_Human1.84216102
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83354261
26MYC_18940864_ChIP-ChIP_HL60_Human1.82893760
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78639467
28P300_19829295_ChIP-Seq_ESCs_Human1.77286488
29TP53_22573176_ChIP-Seq_HFKS_Human1.76729493
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75583794
31EZH2_22144423_ChIP-Seq_EOC_Human1.75096662
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74506377
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71253929
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68197888
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.63736932
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61199788
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52463104
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49675676
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45434267
40BCAT_22108803_ChIP-Seq_LS180_Human1.43877671
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.40916553
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40916553
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40570071
44FOXP3_21729870_ChIP-Seq_TREG_Human1.39580763
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.39127092
46NANOG_19829295_ChIP-Seq_ESCs_Human1.38928122
47SOX2_19829295_ChIP-Seq_ESCs_Human1.38928122
48CBP_20019798_ChIP-Seq_JUKART_Human1.37886077
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37886077
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31467678
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28705612
52HOXB7_26014856_ChIP-Seq_BT474_Human1.28056162
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27546789
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27331761
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25634553
56AR_20517297_ChIP-Seq_VCAP_Human1.24425410
57STAT3_23295773_ChIP-Seq_U87_Human1.21702754
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18196445
59RNF2_27304074_Chip-Seq_NSC_Mouse1.16296456
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15482096
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14887623
62TCF4_23295773_ChIP-Seq_U87_Human1.14732508
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14676061
64NCOR_22424771_ChIP-Seq_293T_Human1.14405986
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.14311070
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13626473
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13037500
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.11388536
69AR_25329375_ChIP-Seq_VCAP_Human1.11357094
70SMAD4_21799915_ChIP-Seq_A2780_Human1.11279942
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10531456
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10524145
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.10351272
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10283672
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10026598
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10026598
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.09546108
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08527531
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.07358190
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07130728
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07124455
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06589180
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06533578
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04914882
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04337176
86TCF4_22108803_ChIP-Seq_LS180_Human1.04197019
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.04038165
88RUNX2_22187159_ChIP-Seq_PCA_Human1.02021472
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01529961
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01072528
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00263407
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.00244113
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98904617
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.98302468
95GATA3_26560356_Chip-Seq_TH2_Human0.97999958
96CBX2_27304074_Chip-Seq_ESCs_Mouse0.97688599
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.97444002
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96056589
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94968694
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92995091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.31656334
2MP0006292_abnormal_olfactory_placode2.63060878
3MP0004147_increased_porphyrin_level2.53565995
4MP0003195_calcinosis2.36637207
5MP0003787_abnormal_imprinting2.26954526
6MP0008058_abnormal_DNA_repair2.22342950
7MP0003718_maternal_effect2.21948549
8MP0006072_abnormal_retinal_apoptosis2.21777449
9MP0005551_abnormal_eye_electrophysiolog2.16715387
10MP0008875_abnormal_xenobiotic_pharmacok2.05784345
11MP0000372_irregular_coat_pigmentation1.99291859
12MP0001968_abnormal_touch/_nociception1.98284680
13MP0005646_abnormal_pituitary_gland1.97765773
14MP0001986_abnormal_taste_sensitivity1.97160502
15MP0002102_abnormal_ear_morphology1.96051735
16MP0003646_muscle_fatigue1.94945928
17MP0008995_early_reproductive_senescence1.91033298
18MP0008872_abnormal_physiological_respon1.85696571
19MP0002837_dystrophic_cardiac_calcinosis1.85407437
20MP0004885_abnormal_endolymph1.84987094
21MP0005084_abnormal_gallbladder_morpholo1.79584510
22MP0001984_abnormal_olfaction1.73956613
23MP0002876_abnormal_thyroid_physiology1.73868590
24MP0001529_abnormal_vocalization1.73682058
25MP0005075_abnormal_melanosome_morpholog1.71682992
26MP0000569_abnormal_digit_pigmentation1.69409455
27MP0005645_abnormal_hypothalamus_physiol1.65993490
28MP0003890_abnormal_embryonic-extraembry1.61349560
29MP0010094_abnormal_chromosome_stability1.57457329
30MP0010386_abnormal_urinary_bladder1.52980229
31MP0005253_abnormal_eye_physiology1.45990264
32MP0004142_abnormal_muscle_tone1.45822171
33MP0002138_abnormal_hepatobiliary_system1.45230417
34MP0009745_abnormal_behavioral_response1.45100586
35MP0004133_heterotaxia1.44303609
36MP0004043_abnormal_pH_regulation1.41142631
37MP0008057_abnormal_DNA_replication1.38506959
38MP0009046_muscle_twitch1.37327724
39MP0002938_white_spotting1.35734209
40MP0005389_reproductive_system_phenotype1.35631178
41MP0002736_abnormal_nociception_after1.35348772
42MP0001501_abnormal_sleep_pattern1.33767513
43MP0002160_abnormal_reproductive_system1.28836421
44MP0001764_abnormal_homeostasis1.28043251
45MP0002272_abnormal_nervous_system1.25661897
46MP0000427_abnormal_hair_cycle1.24824406
47MP0001929_abnormal_gametogenesis1.23944661
48MP0002928_abnormal_bile_duct1.21630565
49MP0003136_yellow_coat_color1.20281919
50MP0001485_abnormal_pinna_reflex1.20139934
51MP0000631_abnormal_neuroendocrine_gland1.17995286
52MP0006276_abnormal_autonomic_nervous1.17688693
53MP0002210_abnormal_sex_determination1.15007216
54MP0001919_abnormal_reproductive_system1.12715882
55MP0003698_abnormal_male_reproductive1.10616234
56MP0003786_premature_aging1.10095565
57MP0003252_abnormal_bile_duct1.09876989
58MP0003283_abnormal_digestive_organ1.09706287
59MP0002638_abnormal_pupillary_reflex1.09152894
60MP0005410_abnormal_fertilization1.06384288
61MP0008789_abnormal_olfactory_epithelium1.05194916
62MP0002277_abnormal_respiratory_mucosa1.04278064
63MP0001486_abnormal_startle_reflex1.04211304
64MP0004145_abnormal_muscle_electrophysio1.03722220
65MP0005379_endocrine/exocrine_gland_phen1.03002802
66MP0003567_abnormal_fetal_cardiomyocyte1.02024152
67MP0002735_abnormal_chemical_nociception1.01184294
68MP0004742_abnormal_vestibular_system1.01131138
69MP0000653_abnormal_sex_gland1.00631505
70MP0005386_behavior/neurological_phenoty1.00319408
71MP0004924_abnormal_behavior1.00319408
72MP0002163_abnormal_gland_morphology0.99221143
73MP0002751_abnormal_autonomic_nervous0.98598368
74MP0009697_abnormal_copulation0.98546491
75MP0003880_abnormal_central_pattern0.98336787
76MP0003121_genomic_imprinting0.97261224
77MP0001145_abnormal_male_reproductive0.95016351
78MP0003806_abnormal_nucleotide_metabolis0.94501357
79MP0002733_abnormal_thermal_nociception0.92852839
80MP0008007_abnormal_cellular_replicative0.91640805
81MP0002557_abnormal_social/conspecific_i0.90621497
82MP0006036_abnormal_mitochondrial_physio0.90478223
83MP0003011_delayed_dark_adaptation0.89553509
84MP0005174_abnormal_tail_pigmentation0.88816899
85MP0001119_abnormal_female_reproductive0.87905499
86MP0002234_abnormal_pharynx_morphology0.87676076
87MP0001970_abnormal_pain_threshold0.86952404
88MP0002572_abnormal_emotion/affect_behav0.85995937
89MP0003119_abnormal_digestive_system0.85445373
90MP0004215_abnormal_myocardial_fiber0.85415511
91MP0005332_abnormal_amino_acid0.84953853
92MP0005195_abnormal_posterior_eye0.84190736
93MP0005085_abnormal_gallbladder_physiolo0.83128887
94MP0001905_abnormal_dopamine_level0.81122064
95MP0005671_abnormal_response_to0.80850727
96MP0000383_abnormal_hair_follicle0.80248215
97MP0002693_abnormal_pancreas_physiology0.78168489
98MP0006035_abnormal_mitochondrial_morpho0.76766980
99MP0002734_abnormal_mechanical_nocicepti0.75754033
100MP0005310_abnormal_salivary_gland0.75566493

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.02658059
2Congenital stationary night blindness (HP:0007642)3.93818084
3Molar tooth sign on MRI (HP:0002419)3.51611323
4Abnormality of midbrain morphology (HP:0002418)3.51611323
5Pancreatic fibrosis (HP:0100732)3.44830475
6True hermaphroditism (HP:0010459)3.24791005
7Abnormality of the renal cortex (HP:0011035)3.13696661
8Type II lissencephaly (HP:0007260)3.13131042
9Nephronophthisis (HP:0000090)3.11728032
10Abolished electroretinogram (ERG) (HP:0000550)2.85837729
11Hypothermia (HP:0002045)2.78644239
12Abnormality of the renal medulla (HP:0100957)2.78603163
13Abnormal rod and cone electroretinograms (HP:0008323)2.66962028
14Acute necrotizing encephalopathy (HP:0006965)2.65367988
15Increased CSF lactate (HP:0002490)2.62720773
16Medial flaring of the eyebrow (HP:0010747)2.61535552
17Mitochondrial inheritance (HP:0001427)2.61291065
18Renal cortical cysts (HP:0000803)2.57548688
19Birth length less than 3rd percentile (HP:0003561)2.55539351
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51773636
21Abnormality of alanine metabolism (HP:0010916)2.51773636
22Hyperalaninemia (HP:0003348)2.51773636
23Inability to walk (HP:0002540)2.51565098
24Progressive macrocephaly (HP:0004481)2.51284007
25Acute encephalopathy (HP:0006846)2.41268804
26Increased hepatocellular lipid droplets (HP:0006565)2.35467866
27Abnormal mitochondria in muscle tissue (HP:0008316)2.34544894
28Supernumerary spleens (HP:0009799)2.34462324
29Progressive inability to walk (HP:0002505)2.33597786
30Chronic hepatic failure (HP:0100626)2.32661572
31Pendular nystagmus (HP:0012043)2.31241584
32Attenuation of retinal blood vessels (HP:0007843)2.30577065
33Lipid accumulation in hepatocytes (HP:0006561)2.29116610
34Stomach cancer (HP:0012126)2.27685021
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27678204
36Hyperglycinuria (HP:0003108)2.26516784
37Polydipsia (HP:0001959)2.26108092
38Abnormal drinking behavior (HP:0030082)2.26108092
39Hepatocellular necrosis (HP:0001404)2.24917507
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.23097852
41Aplasia/Hypoplasia of the spleen (HP:0010451)2.22648580
42Abnormal biliary tract physiology (HP:0012439)2.20883815
43Bile duct proliferation (HP:0001408)2.20883815
44Cystic liver disease (HP:0006706)2.19305762
45Asplenia (HP:0001746)2.19078392
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16084894
47Volvulus (HP:0002580)2.14248742
48Meckel diverticulum (HP:0002245)2.12035234
49Optic disc pallor (HP:0000543)2.11314726
50Sclerocornea (HP:0000647)2.10642585
51Hepatic necrosis (HP:0002605)2.10209277
52Abnormality of the ileum (HP:0001549)2.08405175
53Cerebellar dysplasia (HP:0007033)2.08349979
54Bilateral microphthalmos (HP:0007633)2.06474755
55Abnormality of the labia minora (HP:0012880)2.05222830
56Hypoplasia of the fovea (HP:0007750)2.02207595
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.02207595
58Tubular atrophy (HP:0000092)2.01069924
59Abnormality of the pons (HP:0007361)1.99931529
60Aplasia/hypoplasia of the uterus (HP:0008684)1.99012253
61Methylmalonic acidemia (HP:0002912)1.98982512
62Hyperventilation (HP:0002883)1.98547600
63Furrowed tongue (HP:0000221)1.98471756
64Gaze-evoked nystagmus (HP:0000640)1.97222709
65Increased serum lactate (HP:0002151)1.95421924
663-Methylglutaconic aciduria (HP:0003535)1.94713827
67Congenital hepatic fibrosis (HP:0002612)1.94289919
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93680691
69Colon cancer (HP:0003003)1.93599097
70Absent thumb (HP:0009777)1.93418912
71Patellar aplasia (HP:0006443)1.92929716
72Hypoplasia of the pons (HP:0012110)1.91888092
73Male pseudohermaphroditism (HP:0000037)1.91493646
74Abnormality of B cell number (HP:0010975)1.90062472
75IgG deficiency (HP:0004315)1.88584369
76Congenital primary aphakia (HP:0007707)1.87331585
77Chromsome breakage (HP:0040012)1.87190386
78Aplasia/Hypoplasia of the tibia (HP:0005772)1.87115918
79Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86939861
80Congenital, generalized hypertrichosis (HP:0004540)1.86534584
81Clubbing of toes (HP:0100760)1.85661552
82Decreased central vision (HP:0007663)1.84524410
83Gait imbalance (HP:0002141)1.84261614
84Aplasia/Hypoplasia of the patella (HP:0006498)1.84241495
85Thyroid-stimulating hormone excess (HP:0002925)1.83127355
86Abnormality of serine family amino acid metabolism (HP:0010894)1.80202975
87Abnormality of glycine metabolism (HP:0010895)1.80202975
88Lissencephaly (HP:0001339)1.79996842
89Abnormality of the preputium (HP:0100587)1.79672472
90Abnormality of the renal collecting system (HP:0004742)1.79526356
91Abnormality of chromosome stability (HP:0003220)1.78474100
92Polyuria (HP:0000103)1.78369658
93Stomatitis (HP:0010280)1.77610091
94Anencephaly (HP:0002323)1.76934540
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.76708154
96Progressive microcephaly (HP:0000253)1.76376626
97Nephrogenic diabetes insipidus (HP:0009806)1.75202669
98Hypomagnesemia (HP:0002917)1.73975893
99Optic nerve hypoplasia (HP:0000609)1.73076696
100Large for gestational age (HP:0001520)1.72555714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.94829252
2ADRBK23.55315584
3ZAK3.47214069
4TAOK33.46304139
5TLK13.05325128
6ACVR1B2.70337693
7TXK2.57871252
8NUAK12.51098503
9WNK32.44633700
10BMPR1B2.37954790
11MAP4K22.20820051
12PINK12.12135873
13WNK42.08364297
14GRK12.04812199
15EIF2AK31.79581765
16TAF11.52661591
17MST41.50968983
18MKNK21.45928048
19VRK11.38442729
20VRK21.38256109
21OXSR11.33034639
22INSRR1.27159629
23PLK41.26751597
24MAP3K41.25069162
25STK391.24034897
26MAPK131.20801745
27PLK31.20177072
28MKNK11.13009671
29DAPK21.10842817
30NME11.07884920
31TNIK1.05594004
32TEC1.04412786
33BCKDK1.03399184
34CASK1.03388455
35ADRBK10.99504419
36KIT0.95107399
37PLK20.89079574
38PBK0.86886683
39MAP4K10.86779735
40TRIM280.85624573
41BRSK20.84164039
42ERBB30.83701068
43CDC70.81948324
44TGFBR10.81268768
45DYRK20.81077411
46PRKCE0.79711200
47FLT30.78516521
48PASK0.77037372
49FGFR20.74814729
50EIF2AK10.74772250
51TIE10.73669073
52BCR0.71911495
53PLK10.69743660
54IKBKB0.69423034
55PHKG10.68944782
56PHKG20.68944782
57TTK0.68185047
58SRPK10.67464166
59ITK0.65194600
60ATR0.64563822
61EIF2AK20.61289591
62PRKCG0.59712383
63MAP2K70.59130253
64CSNK1G20.59057661
65PRKCI0.57913646
66STK30.57096606
67PRKCQ0.54813519
68GRK70.51143628
69SYK0.50852553
70PAK30.50579506
71CHEK20.49938582
72TSSK60.49850117
73ATM0.47456520
74NTRK20.44884731
75NEK20.43863313
76BMPR20.43308559
77CSNK1G30.41875770
78MAP2K20.41738380
79CAMKK20.41518322
80PTK2B0.40910711
81WEE10.40899500
82PIK3CA0.39601176
83CAMK2A0.39481463
84MUSK0.39413231
85CSNK1G10.39072419
86MAP2K60.37476835
87PRKACA0.37223418
88RPS6KA50.37096262
89LYN0.36363535
90CSNK1A10.35866565
91CSNK2A10.35442525
92PNCK0.35138692
93GRK50.34350143
94MAPKAPK50.32448974
95NTRK30.32142351
96GRK60.31145423
97IGF1R0.30577967
98AURKB0.29370146
99PRKCA0.29283801
100BTK0.28067525

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.59536158
2Phototransduction_Homo sapiens_hsa047442.55739919
3Oxidative phosphorylation_Homo sapiens_hsa001902.49805956
4Basal transcription factors_Homo sapiens_hsa030222.47161215
5Linoleic acid metabolism_Homo sapiens_hsa005912.43990832
6Protein export_Homo sapiens_hsa030602.34085999
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29713159
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20551743
9Fanconi anemia pathway_Homo sapiens_hsa034602.13858626
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09684994
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.05940772
12RNA polymerase_Homo sapiens_hsa030202.05261618
13Non-homologous end-joining_Homo sapiens_hsa034502.03626484
14Selenocompound metabolism_Homo sapiens_hsa004502.00668983
15Parkinsons disease_Homo sapiens_hsa050121.98721167
16Proteasome_Homo sapiens_hsa030501.97639680
17Nitrogen metabolism_Homo sapiens_hsa009101.94243698
18RNA degradation_Homo sapiens_hsa030181.78903408
19Butanoate metabolism_Homo sapiens_hsa006501.76987975
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75311607
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72371331
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71155701
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70887718
24Mismatch repair_Homo sapiens_hsa034301.65026903
25Ribosome_Homo sapiens_hsa030101.61758267
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60859870
27Nicotine addiction_Homo sapiens_hsa050331.58868325
28Ether lipid metabolism_Homo sapiens_hsa005651.55681801
29Propanoate metabolism_Homo sapiens_hsa006401.48259426
30One carbon pool by folate_Homo sapiens_hsa006701.42324475
31Primary immunodeficiency_Homo sapiens_hsa053401.39741224
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38898397
33Caffeine metabolism_Homo sapiens_hsa002321.37095360
34DNA replication_Homo sapiens_hsa030301.36446556
35Olfactory transduction_Homo sapiens_hsa047401.34101634
36Huntingtons disease_Homo sapiens_hsa050161.33656532
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30110510
38Tryptophan metabolism_Homo sapiens_hsa003801.26755751
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25966700
40RNA transport_Homo sapiens_hsa030131.22705451
41Base excision repair_Homo sapiens_hsa034101.20387090
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.18651165
43Taste transduction_Homo sapiens_hsa047421.17949281
44Nucleotide excision repair_Homo sapiens_hsa034201.14768894
45Regulation of autophagy_Homo sapiens_hsa041401.13330817
46Arachidonic acid metabolism_Homo sapiens_hsa005901.08532370
47Alzheimers disease_Homo sapiens_hsa050101.07673327
48Pyrimidine metabolism_Homo sapiens_hsa002401.04862795
49Peroxisome_Homo sapiens_hsa041461.04761999
50Asthma_Homo sapiens_hsa053101.02317348
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01573564
52Purine metabolism_Homo sapiens_hsa002301.00938769
53Cardiac muscle contraction_Homo sapiens_hsa042601.00642185
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96788445
55Morphine addiction_Homo sapiens_hsa050320.95500569
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.90224656
57Spliceosome_Homo sapiens_hsa030400.85453897
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.83070763
59Chemical carcinogenesis_Homo sapiens_hsa052040.82904772
60Retinol metabolism_Homo sapiens_hsa008300.77553916
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75509219
62Type I diabetes mellitus_Homo sapiens_hsa049400.75028513
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74588135
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.72517692
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70294822
66Steroid biosynthesis_Homo sapiens_hsa001000.67874061
67Metabolic pathways_Homo sapiens_hsa011000.66224473
68GABAergic synapse_Homo sapiens_hsa047270.66025531
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65424393
70Serotonergic synapse_Homo sapiens_hsa047260.65139717
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64243694
72Ovarian steroidogenesis_Homo sapiens_hsa049130.63872969
73Insulin secretion_Homo sapiens_hsa049110.63000137
74Fatty acid elongation_Homo sapiens_hsa000620.62938059
75Collecting duct acid secretion_Homo sapiens_hsa049660.62722675
76Sulfur metabolism_Homo sapiens_hsa009200.62671119
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59932467
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59526658
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58593700
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56928230
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56272544
82ABC transporters_Homo sapiens_hsa020100.56086396
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53523299
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53125610
85beta-Alanine metabolism_Homo sapiens_hsa004100.52414969
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47973979
87Allograft rejection_Homo sapiens_hsa053300.45706743
88Autoimmune thyroid disease_Homo sapiens_hsa053200.45110147
89Graft-versus-host disease_Homo sapiens_hsa053320.44897081
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44116364
91Antigen processing and presentation_Homo sapiens_hsa046120.42865848
92Fat digestion and absorption_Homo sapiens_hsa049750.39977423
93Circadian entrainment_Homo sapiens_hsa047130.39323834
94Salivary secretion_Homo sapiens_hsa049700.38794258
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36655303
96Glutamatergic synapse_Homo sapiens_hsa047240.35541136
97Calcium signaling pathway_Homo sapiens_hsa040200.34029562
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.33853577
99Mineral absorption_Homo sapiens_hsa049780.32928096
100Vitamin digestion and absorption_Homo sapiens_hsa049770.32788160

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