ZNF26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.07341983
2indolalkylamine metabolic process (GO:0006586)4.34770246
3tryptophan catabolic process (GO:0006569)4.24082578
4indole-containing compound catabolic process (GO:0042436)4.24082578
5indolalkylamine catabolic process (GO:0046218)4.24082578
6kynurenine metabolic process (GO:0070189)4.23440980
7L-fucose catabolic process (GO:0042355)4.05243240
8fucose catabolic process (GO:0019317)4.05243240
9L-fucose metabolic process (GO:0042354)4.05243240
10serotonin metabolic process (GO:0042428)3.80237300
11primary amino compound metabolic process (GO:1901160)3.66947587
12sulfation (GO:0051923)3.66741830
13gamma-aminobutyric acid transport (GO:0015812)3.62139856
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61908327
15indole-containing compound metabolic process (GO:0042430)3.54082874
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49898999
17tryptophan metabolic process (GO:0006568)3.46871060
18regulation of gene silencing by miRNA (GO:0060964)3.42952552
19regulation of gene silencing by RNA (GO:0060966)3.42952552
20regulation of posttranscriptional gene silencing (GO:0060147)3.42952552
21regulation of hippo signaling (GO:0035330)3.33928422
22interkinetic nuclear migration (GO:0022027)3.31844679
23cellular response to ATP (GO:0071318)3.30747652
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29007444
25detection of light stimulus involved in sensory perception (GO:0050962)3.28589604
26detection of light stimulus involved in visual perception (GO:0050908)3.28589604
27response to pheromone (GO:0019236)3.28124389
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.24301789
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.24301789
30regulation of translation, ncRNA-mediated (GO:0045974)3.24301789
31cell proliferation in forebrain (GO:0021846)3.16775084
32DNA deamination (GO:0045006)3.14917537
33positive regulation of fatty acid oxidation (GO:0046321)3.13417119
34negative regulation of systemic arterial blood pressure (GO:0003085)3.12211305
35negative regulation of telomere maintenance (GO:0032205)3.10898964
36protein polyglutamylation (GO:0018095)3.06112599
37positive regulation of fatty acid beta-oxidation (GO:0032000)3.01223540
38neuronal action potential (GO:0019228)2.98128429
39reflex (GO:0060004)2.91177952
40epithelial cilium movement (GO:0003351)2.87013821
41negative regulation of mast cell activation (GO:0033004)2.85517149
42snRNA transcription (GO:0009301)2.83767943
43cilium or flagellum-dependent cell motility (GO:0001539)2.82191715
44neural tube formation (GO:0001841)2.81343839
45nonmotile primary cilium assembly (GO:0035058)2.79966782
46axoneme assembly (GO:0035082)2.79386209
47kidney morphogenesis (GO:0060993)2.77481207
48negative regulation of transcription regulatory region DNA binding (GO:2000678)2.76502913
49regulation of mesoderm development (GO:2000380)2.76416127
50regulation of action potential (GO:0098900)2.73441116
51transmission of nerve impulse (GO:0019226)2.72551167
52cornea development in camera-type eye (GO:0061303)2.71748683
53membrane depolarization during action potential (GO:0086010)2.71571503
54parturition (GO:0007567)2.71556939
55oxidative demethylation (GO:0070989)2.70821720
56cellular biogenic amine catabolic process (GO:0042402)2.70507146
57amine catabolic process (GO:0009310)2.70507146
58behavioral response to ethanol (GO:0048149)2.69238593
59cellular response to exogenous dsRNA (GO:0071360)2.68274097
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68193889
61water-soluble vitamin biosynthetic process (GO:0042364)2.68176809
62protein import into peroxisome matrix (GO:0016558)2.67930391
63protein K48-linked deubiquitination (GO:0071108)2.67511464
64negative regulation of response to food (GO:0032096)2.63391650
65negative regulation of appetite (GO:0032099)2.63391650
66preassembly of GPI anchor in ER membrane (GO:0016254)2.60649763
67cardiovascular system development (GO:0072358)2.60645262
68spinal cord motor neuron differentiation (GO:0021522)2.60628645
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60175234
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.60175234
71NADH dehydrogenase complex assembly (GO:0010257)2.60175234
72cellular ketone body metabolic process (GO:0046950)2.57200606
73cilium movement (GO:0003341)2.54501804
74endoderm formation (GO:0001706)2.54324099
75somite development (GO:0061053)2.53398361
76multicellular organism reproduction (GO:0032504)2.51632907
77positive regulation of fatty acid transport (GO:2000193)2.51562661
78cAMP catabolic process (GO:0006198)2.49848735
79NAD biosynthetic process (GO:0009435)2.49716234
80synaptic transmission, cholinergic (GO:0007271)2.47506632
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47023498
82reciprocal DNA recombination (GO:0035825)2.43888109
83reciprocal meiotic recombination (GO:0007131)2.43888109
84purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.43120827
853-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.43120827
86head development (GO:0060322)2.42665034
87protein K11-linked deubiquitination (GO:0035871)2.41929735
88regulation of telomere maintenance (GO:0032204)2.41846752
89ovulation cycle (GO:0042698)2.41091187
90positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.40819592
91regulation of rhodopsin mediated signaling pathway (GO:0022400)2.39694648
92negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36614342
93regulation of cilium movement (GO:0003352)2.35547999
94cilium organization (GO:0044782)2.34809888
95rRNA catabolic process (GO:0016075)2.34050873
96rhodopsin mediated signaling pathway (GO:0016056)2.33779520
97positive regulation of defense response to virus by host (GO:0002230)2.33101516
98drug catabolic process (GO:0042737)2.29987730
99negative regulation of sodium ion transport (GO:0010766)2.29601516
100protein complex biogenesis (GO:0070271)2.29204998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.41665536
2ZNF274_21170338_ChIP-Seq_K562_Hela3.36558590
3VDR_22108803_ChIP-Seq_LS180_Human3.02273948
4GBX2_23144817_ChIP-Seq_PC3_Human2.99250089
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74342032
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43097761
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38875469
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37622747
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07830192
10IGF1R_20145208_ChIP-Seq_DFB_Human1.99052790
11CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95093359
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87900573
13EWS_26573619_Chip-Seq_HEK293_Human1.87386728
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86554168
15TAF15_26573619_Chip-Seq_HEK293_Human1.82425080
16ER_23166858_ChIP-Seq_MCF-7_Human1.82060517
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78766861
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76733632
19FUS_26573619_Chip-Seq_HEK293_Human1.76037921
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.74995712
21P300_19829295_ChIP-Seq_ESCs_Human1.74261565
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.71672749
23REST_21632747_ChIP-Seq_MESCs_Mouse1.70275247
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69994511
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63689841
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62730965
27* STAT3_23295773_ChIP-Seq_U87_Human1.61276716
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54610258
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51672557
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51672557
31* IRF1_19129219_ChIP-ChIP_H3396_Human1.51581595
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51395159
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50883856
34TCF4_23295773_ChIP-Seq_U87_Human1.50110310
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.49215992
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49017653
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48167203
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.48164228
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.47777482
40DROSHA_22980978_ChIP-Seq_HELA_Human1.47346987
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46694467
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.46446255
43SMAD4_21799915_ChIP-Seq_A2780_Human1.45285249
44BCAT_22108803_ChIP-Seq_LS180_Human1.42336880
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39244765
46CBP_20019798_ChIP-Seq_JUKART_Human1.37913490
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37913490
48RNF2_27304074_Chip-Seq_NSC_Mouse1.37509761
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36083537
50AR_25329375_ChIP-Seq_VCAP_Human1.35910636
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34573678
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34470310
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33698846
54AR_21572438_ChIP-Seq_LNCaP_Human1.33272913
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.33170806
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32710733
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.28151543
58TP53_16413492_ChIP-PET_HCT116_Human1.26425306
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.25756833
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.24374105
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24105633
62TP53_22573176_ChIP-Seq_HFKS_Human1.22028750
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20568802
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20110735
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19568224
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19336461
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19200557
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17542053
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.17234248
70RUNX2_22187159_ChIP-Seq_PCA_Human1.17157799
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16635927
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.16190680
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14774982
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.14572603
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13851141
76TCF4_22108803_ChIP-Seq_LS180_Human1.13767802
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.12597255
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12300477
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.12300477
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09860827
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09316936
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09180408
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08003317
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06922132
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06778622
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05530137
87NCOR_22424771_ChIP-Seq_293T_Human1.05436321
88SOX2_19829295_ChIP-Seq_ESCs_Human1.04987142
89NANOG_19829295_ChIP-Seq_ESCs_Human1.04987142
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02903372
91HOXB7_26014856_ChIP-Seq_BT474_Human1.02273195
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01241465
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.01091197
94MYC_18940864_ChIP-ChIP_HL60_Human1.00151386
95AHR_22903824_ChIP-Seq_MCF-7_Human0.99614530
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.99386057
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.99043746
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98833846
99KDM2B_26808549_Chip-Seq_REH_Human0.98297801
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98253079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.31675580
2MP0000569_abnormal_digit_pigmentation3.30645138
3MP0003195_calcinosis2.83604382
4MP0006292_abnormal_olfactory_placode2.54958875
5MP0008877_abnormal_DNA_methylation2.34595222
6MP0005551_abnormal_eye_electrophysiolog2.32027028
7MP0001968_abnormal_touch/_nociception2.18687994
8MP0002837_dystrophic_cardiac_calcinosis2.18584328
9MP0003787_abnormal_imprinting2.08459750
10MP0009745_abnormal_behavioral_response2.02529283
11MP0009046_muscle_twitch1.99276548
12MP0005646_abnormal_pituitary_gland1.98644560
13MP0004142_abnormal_muscle_tone1.97939320
14MP0004885_abnormal_endolymph1.94743178
15MP0002160_abnormal_reproductive_system1.93046057
16MP0002102_abnormal_ear_morphology1.91535695
17MP0001986_abnormal_taste_sensitivity1.91416103
18MP0002876_abnormal_thyroid_physiology1.89748661
19MP0004130_abnormal_muscle_cell1.89022399
20MP0001485_abnormal_pinna_reflex1.85829389
21MP0008872_abnormal_physiological_respon1.83890600
22MP0004043_abnormal_pH_regulation1.82858765
23MP0002272_abnormal_nervous_system1.80058987
24MP0004145_abnormal_muscle_electrophysio1.79798646
25MP0002653_abnormal_ependyma_morphology1.75357504
26MP0000631_abnormal_neuroendocrine_gland1.70551553
27MP0004133_heterotaxia1.70148793
28MP0005645_abnormal_hypothalamus_physiol1.69562226
29MP0003136_yellow_coat_color1.65135691
30MP0002638_abnormal_pupillary_reflex1.62857882
31MP0006276_abnormal_autonomic_nervous1.60852483
32MP0002735_abnormal_chemical_nociception1.60053284
33MP0000427_abnormal_hair_cycle1.58030122
34MP0001501_abnormal_sleep_pattern1.53791573
35MP0005174_abnormal_tail_pigmentation1.51948457
36MP0005389_reproductive_system_phenotype1.50629815
37MP0004147_increased_porphyrin_level1.48623942
38MP0002572_abnormal_emotion/affect_behav1.44717586
39MP0003890_abnormal_embryonic-extraembry1.44590663
40MP0002736_abnormal_nociception_after1.44532630
41MP0002064_seizures1.44054734
42MP0004742_abnormal_vestibular_system1.41717592
43MP0002928_abnormal_bile_duct1.40228773
44MP0001486_abnormal_startle_reflex1.39750695
45MP0003011_delayed_dark_adaptation1.34618210
46MP0003880_abnormal_central_pattern1.33933113
47MP0002733_abnormal_thermal_nociception1.33054489
48MP0004924_abnormal_behavior1.31843415
49MP0005386_behavior/neurological_phenoty1.31843415
50MP0005423_abnormal_somatic_nervous1.30361747
51MP0001970_abnormal_pain_threshold1.30196567
52MP0002557_abnormal_social/conspecific_i1.28922762
53MP0002938_white_spotting1.28304327
54MP0006072_abnormal_retinal_apoptosis1.26405707
55MP0005253_abnormal_eye_physiology1.25613467
56MP0003635_abnormal_synaptic_transmissio1.24597973
57MP0002063_abnormal_learning/memory/cond1.23357867
58MP0001440_abnormal_grooming_behavior1.22360237
59MP0002067_abnormal_sensory_capabilities1.21287951
60MP0008775_abnormal_heart_ventricle1.18705220
61MP0008875_abnormal_xenobiotic_pharmacok1.15537247
62MP0000230_abnormal_systemic_arterial1.12442043
63MP0000778_abnormal_nervous_system1.07141015
64MP0008961_abnormal_basal_metabolism1.06546692
65MP0000383_abnormal_hair_follicle1.03280644
66MP0005195_abnormal_posterior_eye1.03212146
67MP0000026_abnormal_inner_ear1.02372165
68MP0003119_abnormal_digestive_system1.01377897
69MP0002138_abnormal_hepatobiliary_system0.99857880
70MP0002184_abnormal_innervation0.99633177
71MP0002752_abnormal_somatic_nervous0.98933184
72MP0002734_abnormal_mechanical_nocicepti0.97939712
73MP0008995_early_reproductive_senescence0.97420389
74MP0003879_abnormal_hair_cell0.95941671
75MP0000049_abnormal_middle_ear0.95917102
76MP0010386_abnormal_urinary_bladder0.93615847
77MP0001963_abnormal_hearing_physiology0.93015267
78MP0001919_abnormal_reproductive_system0.91084879
79MP0005084_abnormal_gallbladder_morpholo0.90477003
80MP0005448_abnormal_energy_balance0.90364420
81MP0003121_genomic_imprinting0.89576441
82MP0002163_abnormal_gland_morphology0.88463757
83MP0002095_abnormal_skin_pigmentation0.85679271
84MP0003937_abnormal_limbs/digits/tail_de0.83412051
85MP0003252_abnormal_bile_duct0.82782413
86MP0001905_abnormal_dopamine_level0.82446513
87MP0002229_neurodegeneration0.81354213
88MP0001502_abnormal_circadian_rhythm0.79772449
89MP0002882_abnormal_neuron_morphology0.76766771
90MP0004215_abnormal_myocardial_fiber0.76642954
91MP0000955_abnormal_spinal_cord0.76338219
92MP0005167_abnormal_blood-brain_barrier0.76248678
93MP0001984_abnormal_olfaction0.75717901
94MP0003698_abnormal_male_reproductive0.74842850
95MP0002234_abnormal_pharynx_morphology0.73655739
96MP0000538_abnormal_urinary_bladder0.73359271
97MP0000470_abnormal_stomach_morphology0.72289290
98MP0005083_abnormal_biliary_tract0.71512318
99MP0005410_abnormal_fertilization0.69816793
100MP0003938_abnormal_ear_development0.69682239

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.63193139
2Genetic anticipation (HP:0003743)4.41901898
3Pancreatic fibrosis (HP:0100732)4.14463983
4Abnormality of midbrain morphology (HP:0002418)4.10370987
5Molar tooth sign on MRI (HP:0002419)4.10370987
6Congenital stationary night blindness (HP:0007642)3.94205581
7True hermaphroditism (HP:0010459)3.91968475
8Progressive cerebellar ataxia (HP:0002073)3.68826947
9Nephronophthisis (HP:0000090)3.63397636
10Hyperventilation (HP:0002883)3.61245589
11Abnormality of the renal medulla (HP:0100957)3.21405879
12Abolished electroretinogram (ERG) (HP:0000550)3.08889633
13Abnormality of the renal cortex (HP:0011035)3.05931440
14Clumsiness (HP:0002312)3.05601872
15Attenuation of retinal blood vessels (HP:0007843)2.99499755
16Gaze-evoked nystagmus (HP:0000640)2.96716962
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.96022361
18Abnormality of alanine metabolism (HP:0010916)2.96022361
19Hyperalaninemia (HP:0003348)2.96022361
20Decreased circulating renin level (HP:0003351)2.92644911
21Cystic liver disease (HP:0006706)2.88002896
22Protruding tongue (HP:0010808)2.85986505
23Pendular nystagmus (HP:0012043)2.85595115
24Chronic hepatic failure (HP:0100626)2.79886706
25Type II lissencephaly (HP:0007260)2.74717846
26Patellar aplasia (HP:0006443)2.71770406
27Tubular atrophy (HP:0000092)2.68049678
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.66590320
29Aplasia/Hypoplasia of the patella (HP:0006498)2.66298268
30Medial flaring of the eyebrow (HP:0010747)2.57377092
31Abnormality of the renal collecting system (HP:0004742)2.52934719
32Broad-based gait (HP:0002136)2.49140561
33Abnormal drinking behavior (HP:0030082)2.46686053
34Polydipsia (HP:0001959)2.46686053
35Chorioretinal atrophy (HP:0000533)2.45723700
36Birth length less than 3rd percentile (HP:0003561)2.45501048
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45366075
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44560528
39Decreased central vision (HP:0007663)2.42091291
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.38267710
41Absent/shortened dynein arms (HP:0200106)2.38267710
42Inability to walk (HP:0002540)2.37146255
43Keratoconus (HP:0000563)2.32889294
44Increased corneal curvature (HP:0100692)2.32889294
45Abnormal rod and cone electroretinograms (HP:0008323)2.32741040
46Furrowed tongue (HP:0000221)2.32224741
47Sclerocornea (HP:0000647)2.30565263
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26770242
49Congenital, generalized hypertrichosis (HP:0004540)2.20999726
50Concave nail (HP:0001598)2.19285079
51Large for gestational age (HP:0001520)2.14657633
52Anencephaly (HP:0002323)2.14435088
53Congenital hepatic fibrosis (HP:0002612)2.13254018
54Bony spicule pigmentary retinopathy (HP:0007737)2.12889389
55Male pseudohermaphroditism (HP:0000037)2.10529097
56Abnormality of the pons (HP:0007361)2.10439329
57Abnormal respiratory epithelium morphology (HP:0012253)2.10011683
58Abnormal respiratory motile cilium morphology (HP:0005938)2.10011683
59Congenital sensorineural hearing impairment (HP:0008527)2.09727291
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.07323914
61Hypoplasia of the pons (HP:0012110)2.05681613
62Gait imbalance (HP:0002141)2.04203046
63Lissencephaly (HP:0001339)1.98939764
64Cerebellar dysplasia (HP:0007033)1.96985067
65Febrile seizures (HP:0002373)1.96592912
66Polyuria (HP:0000103)1.95217609
67Fair hair (HP:0002286)1.95086720
68Small hand (HP:0200055)1.94397059
69Progressive inability to walk (HP:0002505)1.93899065
70Congenital primary aphakia (HP:0007707)1.92987754
71Renal cortical cysts (HP:0000803)1.88754277
72Duplicated collecting system (HP:0000081)1.88078145
73Abnormality of DNA repair (HP:0003254)1.83667953
74Absent speech (HP:0001344)1.81852368
75Agitation (HP:0000713)1.80371709
76Postaxial foot polydactyly (HP:0001830)1.79395560
77Abnormality of the nasal septum (HP:0000419)1.78796958
78Abnormal ciliary motility (HP:0012262)1.78745073
79Metabolic alkalosis (HP:0200114)1.78699764
80Bulbous nose (HP:0000414)1.76996202
81Genital tract atresia (HP:0001827)1.76319822
82Absent thumb (HP:0009777)1.75302929
83Nephrogenic diabetes insipidus (HP:0009806)1.75214995
84Stomach cancer (HP:0012126)1.74014056
85Vaginal atresia (HP:0000148)1.72491620
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.72232308
87Abnormal biliary tract physiology (HP:0012439)1.69195682
88Bile duct proliferation (HP:0001408)1.69195682
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.69192719
90Poor coordination (HP:0002370)1.68566428
91Tachypnea (HP:0002789)1.68094290
92Severe muscular hypotonia (HP:0006829)1.67144046
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66365634
94Impaired smooth pursuit (HP:0007772)1.65238603
95Focal seizures (HP:0007359)1.64634363
96Abnormality of renin-angiotensin system (HP:0000847)1.64443679
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63538596
98Hemiparesis (HP:0001269)1.62716763
99Short tibia (HP:0005736)1.62601780
100Pachygyria (HP:0001302)1.61694340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.02176812
2ACVR1B3.99407485
3BMPR1B3.55519925
4ADRBK23.18838290
5TLK12.69429960
6TAOK32.44603689
7GRK12.39602543
8INSRR2.24771552
9WNK42.24274042
10CASK2.10877351
11ZAK1.99786099
12WNK31.92315328
13PINK11.86435749
14MAPK131.68719525
15NUAK11.55655374
16OXSR11.52198169
17CAMKK21.46818258
18DAPK21.45861676
19TGFBR11.42995997
20ADRBK11.42417070
21TXK1.37052496
22MKNK21.35021205
23CAMK1D1.34439820
24MAP4K21.30335120
25MAPK151.30268134
26MAP3K41.24947376
27STK391.24710877
28PIK3CA1.22590805
29NTRK31.17070129
30AKT31.12992000
31SIK21.01683364
32CAMK1G0.94439854
33NTRK20.92021424
34PAK30.91348791
35SGK20.90798342
36PRKCG0.88716578
37KIT0.86341118
38TRPM70.83741807
39TEC0.83689009
40PTK2B0.83292726
41STK110.81152461
42MARK10.76433297
43PNCK0.75455530
44TIE10.75256899
45NEK20.74920887
46DYRK20.73162628
47SGK4940.72810924
48SGK2230.72810924
49RPS6KA60.72725356
50CAMK10.71367080
51MAP2K60.70436963
52CAMKK10.67592945
53PRKCE0.67430231
54CHUK0.66883209
55IRAK10.66734702
56IKBKB0.65437393
57TNIK0.65074530
58PKN10.64538862
59MAPKAPK30.62854364
60ERBB20.59488770
61RPS6KA50.59372557
62MAP3K70.57739237
63STK38L0.57346072
64MAP2K70.55921452
65ITK0.55530385
66FGFR20.54303137
67PRKCQ0.54119629
68PRKD20.53575720
69TNK20.51876419
70MAP4K10.51871088
71CAMK2A0.51162390
72BRSK20.50873056
73PRKAA20.48301832
74CDK190.48297556
75PRKACA0.47864126
76PRKCH0.47264737
77MELK0.45901491
78GRK70.45545371
79SYK0.45285688
80NLK0.44317796
81WNK10.43848591
82CAMK40.41955120
83MAP2K40.41622324
84PRKCZ0.41193905
85SGK10.41128236
86MUSK0.40194758
87PRKAA10.38478505
88PHKG10.38132633
89PHKG20.38132633
90OBSCN0.37732681
91CSNK1A10.36075226
92MARK30.35328243
93FLT30.34107886
94TYRO30.33421901
95MAP2K10.32814359
96PRKCA0.32592123
97PLK20.32397789
98BTK0.31773000
99MAPKAPK50.31294811
100CSNK1D0.31266518

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.91121780
2Nicotine addiction_Homo sapiens_hsa050332.71436878
3Nitrogen metabolism_Homo sapiens_hsa009102.54151842
4Linoleic acid metabolism_Homo sapiens_hsa005912.53916423
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35954336
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.31300567
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22170207
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10296371
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04120700
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97906923
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91418150
12Tryptophan metabolism_Homo sapiens_hsa003801.90139767
13Morphine addiction_Homo sapiens_hsa050321.87446733
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.80053231
15Taste transduction_Homo sapiens_hsa047421.79102949
16Butanoate metabolism_Homo sapiens_hsa006501.71542473
17Selenocompound metabolism_Homo sapiens_hsa004501.68896769
18Olfactory transduction_Homo sapiens_hsa047401.60311889
19Ether lipid metabolism_Homo sapiens_hsa005651.59032519
20Homologous recombination_Homo sapiens_hsa034401.56948027
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.55752675
22Caffeine metabolism_Homo sapiens_hsa002321.51599190
23ABC transporters_Homo sapiens_hsa020101.51249489
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46941425
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44015762
26Glutamatergic synapse_Homo sapiens_hsa047241.42436138
27Serotonergic synapse_Homo sapiens_hsa047261.39685313
28Circadian entrainment_Homo sapiens_hsa047131.38885736
29Fanconi anemia pathway_Homo sapiens_hsa034601.36464118
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.31906627
31GABAergic synapse_Homo sapiens_hsa047271.28046367
32RNA polymerase_Homo sapiens_hsa030201.26783506
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26548446
34Insulin secretion_Homo sapiens_hsa049111.20856607
35Chemical carcinogenesis_Homo sapiens_hsa052041.19736602
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15922775
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12579883
38Retinol metabolism_Homo sapiens_hsa008301.10790365
39Basal transcription factors_Homo sapiens_hsa030221.10043568
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09413143
41Calcium signaling pathway_Homo sapiens_hsa040201.09087893
42Oxidative phosphorylation_Homo sapiens_hsa001901.07271771
43Dorso-ventral axis formation_Homo sapiens_hsa043201.05018349
44Ovarian steroidogenesis_Homo sapiens_hsa049131.04958833
45Glycerolipid metabolism_Homo sapiens_hsa005611.01303664
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.99489722
47Cholinergic synapse_Homo sapiens_hsa047250.98095018
48Cardiac muscle contraction_Homo sapiens_hsa042600.92907240
49Arachidonic acid metabolism_Homo sapiens_hsa005900.86924708
50Salivary secretion_Homo sapiens_hsa049700.85112002
51Sulfur relay system_Homo sapiens_hsa041220.83050903
52Histidine metabolism_Homo sapiens_hsa003400.82972782
53Asthma_Homo sapiens_hsa053100.81802040
54Dopaminergic synapse_Homo sapiens_hsa047280.78985088
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78196334
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.77184177
57RNA degradation_Homo sapiens_hsa030180.76616475
58Peroxisome_Homo sapiens_hsa041460.74603313
59Vitamin digestion and absorption_Homo sapiens_hsa049770.73695721
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73223616
61Oxytocin signaling pathway_Homo sapiens_hsa049210.72152980
62cAMP signaling pathway_Homo sapiens_hsa040240.71814714
63Cocaine addiction_Homo sapiens_hsa050300.70276348
64Long-term depression_Homo sapiens_hsa047300.69113950
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68733961
66Primary immunodeficiency_Homo sapiens_hsa053400.66973192
67Regulation of autophagy_Homo sapiens_hsa041400.66311797
68Parkinsons disease_Homo sapiens_hsa050120.66149022
69Gastric acid secretion_Homo sapiens_hsa049710.66062240
70Graft-versus-host disease_Homo sapiens_hsa053320.62510620
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62275622
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58511356
73Huntingtons disease_Homo sapiens_hsa050160.58090346
74Fatty acid biosynthesis_Homo sapiens_hsa000610.57842914
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56822073
76Type II diabetes mellitus_Homo sapiens_hsa049300.56653135
77Fat digestion and absorption_Homo sapiens_hsa049750.56216417
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53889409
79MAPK signaling pathway_Homo sapiens_hsa040100.52003856
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51930316
81Alzheimers disease_Homo sapiens_hsa050100.51290394
82beta-Alanine metabolism_Homo sapiens_hsa004100.51197485
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51172472
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48936847
85Renin secretion_Homo sapiens_hsa049240.48093596
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45613786
87Melanoma_Homo sapiens_hsa052180.45007149
88Allograft rejection_Homo sapiens_hsa053300.44511597
89Hedgehog signaling pathway_Homo sapiens_hsa043400.42463928
90Mineral absorption_Homo sapiens_hsa049780.42421251
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41807158
92Type I diabetes mellitus_Homo sapiens_hsa049400.41547535
93Amphetamine addiction_Homo sapiens_hsa050310.41503866
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41302334
95Ras signaling pathway_Homo sapiens_hsa040140.40294112
96One carbon pool by folate_Homo sapiens_hsa006700.40033306
97Lysine degradation_Homo sapiens_hsa003100.39609386
98Axon guidance_Homo sapiens_hsa043600.38444052
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.37741883
100Basal cell carcinoma_Homo sapiens_hsa052170.36340138

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