ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	3.96078204
2	DNA double-strand break processing (GO:0000729)	3.81728629
3	presynaptic membrane assembly (GO:0097105)	3.81182217
4	response to pheromone (GO:0019236)	3.72608070
5	nonmotile primary cilium assembly (GO:0035058)	3.49188958
6	behavioral response to nicotine (GO:0035095)	3.45253010
7	presynaptic membrane organization (GO:0097090)	3.38968907
8	neural tube formation (GO:0001841)	3.33785987
9	intraciliary transport (GO:0042073)	3.29566141
10	nucleobase catabolic process (GO:0046113)	3.20199002
11	cilium morphogenesis (GO:0060271)	3.11507038
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.10119571
13	epithelial cilium movement (GO:0003351)	3.05161077
14	resolution of meiotic recombination intermediates (GO:0000712)	3.00060733
15	limb bud formation (GO:0060174)	2.99437100
16	forebrain neuron differentiation (GO:0021879)	2.97279619
17	replication fork processing (GO:0031297)	2.88895639
18	olfactory bulb development (GO:0021772)	2.84519015
19	neuron cell-cell adhesion (GO:0007158)	2.83268634
20	head development (GO:0060322)	2.80630918
21	retinal ganglion cell axon guidance (GO:0031290)	2.77109369
22	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.75188832
23	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.75188832
24	somite development (GO:0061053)	2.75016089
25	water-soluble vitamin biosynthetic process (GO:0042364)	2.74008344
26	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.70029124
27	cholesterol biosynthetic process (GO:0006695)	2.68429691
28	chromatin remodeling at centromere (GO:0031055)	2.67501513
29	peptidyl-histidine modification (GO:0018202)	2.65983970
30	positive regulation of mitochondrial fission (GO:0090141)	2.65419704
31	regulation of cilium movement (GO:0003352)	2.64773403
32	limb development (GO:0060173)	2.62929976
33	appendage development (GO:0048736)	2.62929976
34	postsynaptic membrane organization (GO:0001941)	2.62646729
35	cilium organization (GO:0044782)	2.61092522
36	protein-cofactor linkage (GO:0018065)	2.60423455
37	fucose catabolic process (GO:0019317)	2.59853103
38	L-fucose metabolic process (GO:0042354)	2.59853103
39	L-fucose catabolic process (GO:0042355)	2.59853103
40	cilium assembly (GO:0042384)	2.58754747
41	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.58380447
42	regulation of mitotic spindle checkpoint (GO:1903504)	2.57318869
43	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.57318869
44	isoprenoid biosynthetic process (GO:0008299)	2.57113324
45	platelet dense granule organization (GO:0060155)	2.55293261
46	cullin deneddylation (GO:0010388)	2.54915099
47	axonal fasciculation (GO:0007413)	2.54072603
48	regulation of development, heterochronic (GO:0040034)	2.52626776
49	DNA damage response, detection of DNA damage (GO:0042769)	2.50851639
50	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.47912520
51	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.47912520
52	regulation of translation, ncRNA-mediated (GO:0045974)	2.47912520
53	DNA integration (GO:0015074)	2.47313171
54	CENP-A containing nucleosome assembly (GO:0034080)	2.44063404
55	sterol biosynthetic process (GO:0016126)	2.43677491
56	cell proliferation in forebrain (GO:0021846)	2.43138416
57	neuronal stem cell maintenance (GO:0097150)	2.42628008
58	negative regulation of DNA recombination (GO:0045910)	2.41896485
59	kidney morphogenesis (GO:0060993)	2.41577653
60	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.41241275
61	ubiquinone metabolic process (GO:0006743)	2.40302348
62	regulation of telomere maintenance (GO:0032204)	2.40279719
63	sympathetic nervous system development (GO:0048485)	2.40144989
64	cilium movement (GO:0003341)	2.39223177
65	regulation of glucokinase activity (GO:0033131)	2.37423656
66	regulation of hexokinase activity (GO:1903299)	2.37423656
67	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.37027699
68	histone H2A acetylation (GO:0043968)	2.36832401
69	regulation of mesoderm development (GO:2000380)	2.34576385
70	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.33815343
71	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.33815343
72	recombinational repair (GO:0000725)	2.33489482
73	C4-dicarboxylate transport (GO:0015740)	2.32249208
74	gamma-aminobutyric acid transport (GO:0015812)	2.30426110
75	photoreceptor cell maintenance (GO:0045494)	2.29698645
76	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.29692196
77	double-strand break repair via homologous recombination (GO:0000724)	2.29290481
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.28405986
79	smoothened signaling pathway (GO:0007224)	2.28153968
80	protein deneddylation (GO:0000338)	2.28082869
81	mechanosensory behavior (GO:0007638)	2.28035549
82	protein localization to cilium (GO:0061512)	2.26848813
83	kinetochore organization (GO:0051383)	2.24283457
84	regulation of timing of cell differentiation (GO:0048505)	2.22527036
85	auditory behavior (GO:0031223)	2.22247291
86	cellular response to cholesterol (GO:0071397)	2.22074027
87	protein polyglutamylation (GO:0018095)	2.21764739
88	negative regulation of telomere maintenance (GO:0032205)	2.20798056
89	reciprocal meiotic recombination (GO:0007131)	2.20322675
90	reciprocal DNA recombination (GO:0035825)	2.20322675
91	cellular response to sterol (GO:0036315)	2.20249146
92	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.20046849
93	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.19525004
94	histone exchange (GO:0043486)	2.18965533
95	regulation of hippo signaling (GO:0035330)	2.18615816
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.18494619
97	microtubule anchoring (GO:0034453)	2.18293755
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.17687099
99	ganglion development (GO:0061548)	2.17306178
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.16929202

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.41155580
2	IGF1R_20145208_ChIP-Seq_DFB_Human	2.88041961
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.85963800
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.78073336
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.66933357
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.64799725
7	FUS_26573619_Chip-Seq_HEK293_Human	2.59359792
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50345478
9	EWS_26573619_Chip-Seq_HEK293_Human	2.46577188
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.45090860
11	VDR_22108803_ChIP-Seq_LS180_Human	2.36688663
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.28837068
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.22631260
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.21386565
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.16523336
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10044801
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.08950082
18	P300_19829295_ChIP-Seq_ESCs_Human	2.07266559
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05290279
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05241856
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01917208
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.98957457
23	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.92373244
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.86377789
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.84723757
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83035239
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77152430
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76452159
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73793321
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.66205295
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.65932415
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.65611716
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.65021702
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.57003037
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51664397
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51546028
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50989399
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.50301823
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48887988
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.48235284
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44973822
42	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44760995
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43416091
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42440933
45	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.40520613
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39726010
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36262209
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35217602
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.34370415
50	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.34231223
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33670785
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32738064
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.32738064
54	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32242536
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31873506
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31142908
57	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.30437262
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30183806
59	STAT3_23295773_ChIP-Seq_U87_Human	1.29250509
60	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.25951088
61	* VDR_23849224_ChIP-Seq_CD4+_Human	1.25929613
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25871271
63	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.21603130
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20818482
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20307925
66	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17332422
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16652776
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.15964475
69	AR_25329375_ChIP-Seq_VCAP_Human	1.14739223
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14634773
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14634773
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13728800
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13587307
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13576164
75	TCF4_23295773_ChIP-Seq_U87_Human	1.13418684
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12465370
77	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12456078
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12294570
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10719942
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09954032
81	* NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09178399
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08277664
83	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.07354812
84	TCF4_22108803_ChIP-Seq_LS180_Human	1.07075933
85	BCAT_22108803_ChIP-Seq_LS180_Human	1.06946641
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06520500
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06321742
88	TP53_22573176_ChIP-Seq_HFKS_Human	1.06121458
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05650873
90	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02252952
91	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02252952
92	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.01847968
93	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01721304
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01718802
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99984961
96	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.98977731
97	JUN_21703547_ChIP-Seq_K562_Human	0.98116583
98	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.98053691
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97058845
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.95321582

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	2.51459343
2	MP0006072_abnormal_retinal_apoptosis	2.44097429
3	MP0008877_abnormal_DNA_methylation	2.42614253
4	MP0006292_abnormal_olfactory_placode	2.34252799
5	MP0003890_abnormal_embryonic-extraembry	2.29263706
6	MP0004133_heterotaxia	2.28354316
7	MP0001529_abnormal_vocalization	2.23540368
8	MP0002102_abnormal_ear_morphology	2.21331024
9	MP0002938_white_spotting	2.13882176
10	MP0003122_maternal_imprinting	2.08654422
11	MP0008789_abnormal_olfactory_epithelium	2.07287118
12	MP0001293_anophthalmia	2.04980973
13	MP0001984_abnormal_olfaction	2.00896179
14	MP0003121_genomic_imprinting	1.88966600
15	MP0002751_abnormal_autonomic_nervous	1.87307915
16	MP0005499_abnormal_olfactory_system	1.86224629
17	MP0005394_taste/olfaction_phenotype	1.86224629
18	MP0003937_abnormal_limbs/digits/tail_de	1.85380847
19	MP0000778_abnormal_nervous_system	1.83898587
20	MP0005253_abnormal_eye_physiology	1.77961144
21	MP0003787_abnormal_imprinting	1.75646893
22	MP0003880_abnormal_central_pattern	1.75390362
23	MP0008058_abnormal_DNA_repair	1.71934591
24	MP0002653_abnormal_ependyma_morphology	1.65992575
25	MP0002736_abnormal_nociception_after	1.57542310
26	MP0006276_abnormal_autonomic_nervous	1.57220182
27	MP0000631_abnormal_neuroendocrine_gland	1.49465016
28	MP0002233_abnormal_nose_morphology	1.47865359
29	MP0005171_absent_coat_pigmentation	1.47777533
30	MP0003119_abnormal_digestive_system	1.47648933
31	MP0009697_abnormal_copulation	1.46550388
32	MP0002638_abnormal_pupillary_reflex	1.45265079
33	MP0005551_abnormal_eye_electrophysiolog	1.42402039
34	MP0005187_abnormal_penis_morphology	1.41239546
35	MP0000049_abnormal_middle_ear	1.39670871
36	MP0000647_abnormal_sebaceous_gland	1.33396910
37	MP0010094_abnormal_chromosome_stability	1.32423047
38	MP0001968_abnormal_touch/_nociception	1.31555049
39	MP0003567_abnormal_fetal_cardiomyocyte	1.29204118
40	MP0000427_abnormal_hair_cycle	1.28682434
41	MP0000569_abnormal_digit_pigmentation	1.28347846
42	MP0008057_abnormal_DNA_replication	1.27993030
43	MP0005248_abnormal_Harderian_gland	1.27634901
44	MP0005391_vision/eye_phenotype	1.24933843
45	MP0001286_abnormal_eye_development	1.24858631
46	MP0001486_abnormal_startle_reflex	1.23841662
47	MP0000383_abnormal_hair_follicle	1.21341836
48	MP0003011_delayed_dark_adaptation	1.17597083
49	MP0002184_abnormal_innervation	1.15843323
50	MP0009046_muscle_twitch	1.15683776
51	MP0000372_irregular_coat_pigmentation	1.14092978
52	MP0004142_abnormal_muscle_tone	1.13815447
53	MP0008932_abnormal_embryonic_tissue	1.13803812
54	MP0003755_abnormal_palate_morphology	1.13629001
55	MP0002095_abnormal_skin_pigmentation	1.12912506
56	MP0001485_abnormal_pinna_reflex	1.11440508
57	MP0000566_synostosis	1.10045114
58	MP0000955_abnormal_spinal_cord	1.09369895
59	MP0002697_abnormal_eye_size	1.07530664
60	MP0001299_abnormal_eye_distance/	1.07053788
61	MP0002234_abnormal_pharynx_morphology	1.04852320
62	MP0003861_abnormal_nervous_system	1.04655734
63	MP0002272_abnormal_nervous_system	1.04585928
64	MP0002557_abnormal_social/conspecific_i	1.04394475
65	MP0005195_abnormal_posterior_eye	1.03853143
66	MP0005645_abnormal_hypothalamus_physiol	1.02956903
67	MP0002752_abnormal_somatic_nervous	1.02849244
68	MP0004885_abnormal_endolymph	1.01912394
69	MP0003938_abnormal_ear_development	1.01729682
70	MP0000516_abnormal_urinary_system	1.00976287
71	MP0005367_renal/urinary_system_phenotyp	1.00976287
72	MP0002084_abnormal_developmental_patter	1.00581898
73	MP0002928_abnormal_bile_duct	1.00180769
74	MP0001188_hyperpigmentation	0.99262526
75	MP0003693_abnormal_embryo_hatching	0.99230222
76	MP0002837_dystrophic_cardiac_calcinosis	0.98287334
77	MP0002822_catalepsy	0.94246650
78	MP0005646_abnormal_pituitary_gland	0.90653944
79	MP0003195_calcinosis	0.90609820
80	MP0003718_maternal_effect	0.90472281
81	MP0002090_abnormal_vision	0.89194514
82	MP0002572_abnormal_emotion/affect_behav	0.88885868
83	MP0010030_abnormal_orbit_morphology	0.88772062
84	MP0003385_abnormal_body_wall	0.87584415
85	MP0009745_abnormal_behavioral_response	0.87217310
86	MP0001324_abnormal_eye_pigmentation	0.87020877
87	MP0002735_abnormal_chemical_nociception	0.86986039
88	MP0000026_abnormal_inner_ear	0.86282834
89	MP0002876_abnormal_thyroid_physiology	0.83565268
90	MP0002152_abnormal_brain_morphology	0.82877870
91	MP0001177_atelectasis	0.81992603
92	MP0003283_abnormal_digestive_organ	0.81679440
93	MP0002111_abnormal_tail_morphology	0.80515289
94	MP0003935_abnormal_craniofacial_develop	0.79820399
95	MP0004197_abnormal_fetal_growth/weight/	0.78587993
96	MP0004924_abnormal_behavior	0.78480721
97	MP0005386_behavior/neurological_phenoty	0.78480721
98	MP0002882_abnormal_neuron_morphology	0.78216208
99	MP0004215_abnormal_myocardial_fiber	0.78128529
100	MP0002092_abnormal_eye_morphology	0.76831736

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.84838371
2	Pancreatic fibrosis (HP:0100732)	3.82988695
3	Pancreatic cysts (HP:0001737)	3.65021706
4	Colon cancer (HP:0003003)	3.27272150
5	Abnormality of midbrain morphology (HP:0002418)	3.18267224
6	Molar tooth sign on MRI (HP:0002419)	3.18267224
7	Medial flaring of the eyebrow (HP:0010747)	3.12590430
8	Nephronophthisis (HP:0000090)	2.94759465
9	Abnormality of the labia minora (HP:0012880)	2.93450584
10	Gait imbalance (HP:0002141)	2.89039199
11	Congenital primary aphakia (HP:0007707)	2.87610259
12	Intestinal atresia (HP:0011100)	2.84483594
13	Chronic hepatic failure (HP:0100626)	2.69746320
14	Genital tract atresia (HP:0001827)	2.67971498
15	Septo-optic dysplasia (HP:0100842)	2.66689424
16	Nephrogenic diabetes insipidus (HP:0009806)	2.65941418
17	Vaginal atresia (HP:0000148)	2.64710566
18	Abnormality of the renal medulla (HP:0100957)	2.62236343
19	Optic nerve hypoplasia (HP:0000609)	2.49159095
20	Hepatoblastoma (HP:0002884)	2.37158176
21	Sclerocornea (HP:0000647)	2.36912128
22	Hyperglycinemia (HP:0002154)	2.33476098
23	Supernumerary spleens (HP:0009799)	2.33341798
24	Cystic liver disease (HP:0006706)	2.32676196
25	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.30437512
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.28346464
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26329960
28	Anophthalmia (HP:0000528)	2.26028013
29	Postaxial foot polydactyly (HP:0001830)	2.25549429
30	Postaxial hand polydactyly (HP:0001162)	2.24566777
31	Anencephaly (HP:0002323)	2.22012554
32	Oligodactyly (hands) (HP:0001180)	2.18449857
33	Poor coordination (HP:0002370)	2.15922477
34	Preaxial hand polydactyly (HP:0001177)	2.15877351
35	Drooling (HP:0002307)	2.15368309
36	Short tibia (HP:0005736)	2.13868727
37	Gastrointestinal atresia (HP:0002589)	2.12172828
38	Pendular nystagmus (HP:0012043)	2.11357312
39	Abnormal biliary tract physiology (HP:0012439)	2.10525201
40	Bile duct proliferation (HP:0001408)	2.10525201
41	Volvulus (HP:0002580)	2.09445387
42	Abolished electroretinogram (ERG) (HP:0000550)	2.06023366
43	Bifid tongue (HP:0010297)	2.03973761
44	Abnormality of the renal cortex (HP:0011035)	2.03646119
45	Occipital encephalocele (HP:0002085)	2.02319848
46	Methylmalonic acidemia (HP:0002912)	2.01896561
47	Broad foot (HP:0001769)	1.98634391
48	Lissencephaly (HP:0001339)	1.97889250
49	Cerebellar dysplasia (HP:0007033)	1.97032999
50	Dandy-Walker malformation (HP:0001305)	1.96192123
51	Type II lissencephaly (HP:0007260)	1.94285366
52	Specific learning disability (HP:0001328)	1.94277572
53	Renal cortical cysts (HP:0000803)	1.91881755
54	Congenital hepatic fibrosis (HP:0002612)	1.89310321
55	Renal hypoplasia (HP:0000089)	1.88996960
56	Excessive salivation (HP:0003781)	1.85867384
57	Abnormality of the ileum (HP:0001549)	1.85807609
58	Male pseudohermaphroditism (HP:0000037)	1.83332290
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.81968604
60	Abnormal lung lobation (HP:0002101)	1.81930572
61	Narrow forehead (HP:0000341)	1.81518141
62	Retinal dysplasia (HP:0007973)	1.81101304
63	Progressive inability to walk (HP:0002505)	1.80864441
64	Meckel diverticulum (HP:0002245)	1.80105433
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79722471
66	Abnormality of alanine metabolism (HP:0010916)	1.79722471
67	Hyperalaninemia (HP:0003348)	1.79722471
68	Thyroid-stimulating hormone excess (HP:0002925)	1.75544462
69	Stenosis of the external auditory canal (HP:0000402)	1.74635391
70	Micropenis (HP:0000054)	1.72733677
71	Glioma (HP:0009733)	1.72102968
72	Neoplasm of the adrenal cortex (HP:0100641)	1.71107218
73	Oligodactyly (HP:0012165)	1.70494587
74	Abnormality of serine family amino acid metabolism (HP:0010894)	1.69761474
75	Abnormality of glycine metabolism (HP:0010895)	1.69761474
76	Chorioretinal atrophy (HP:0000533)	1.69653095
77	Decreased testicular size (HP:0008734)	1.69235166
78	Hyperventilation (HP:0002883)	1.68870089
79	Hyperglycinuria (HP:0003108)	1.68327745
80	Rib fusion (HP:0000902)	1.68014043
81	Labial hypoplasia (HP:0000066)	1.67897072
82	Esophageal atresia (HP:0002032)	1.67399557
83	Aganglionic megacolon (HP:0002251)	1.67118572
84	Inability to walk (HP:0002540)	1.67073405
85	Bilateral microphthalmos (HP:0007633)	1.66275791
86	Astigmatism (HP:0000483)	1.65662382
87	Absent septum pellucidum (HP:0001331)	1.64057777
88	Multicystic kidney dysplasia (HP:0000003)	1.63691304
89	Aqueductal stenosis (HP:0002410)	1.63636016
90	Tubular atrophy (HP:0000092)	1.63558429
91	Rhabdomyosarcoma (HP:0002859)	1.63019879
92	Cutaneous finger syndactyly (HP:0010554)	1.62323535
93	Abnormality of serum amino acid levels (HP:0003112)	1.61982251
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.61702594
95	Broad-based gait (HP:0002136)	1.60373442
96	Sloping forehead (HP:0000340)	1.59682145
97	Patellar aplasia (HP:0006443)	1.59511497
98	Pachygyria (HP:0001302)	1.58227512
99	Keratoconus (HP:0000563)	1.58143923
100	Increased corneal curvature (HP:0100692)	1.58143923

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.31611606
2	FRK	3.15700327
3	CASK	2.92738111
4	MAP3K4	2.54347192
5	TRIM28	2.53387248
6	BMPR1B	2.47391151
7	BCR	2.33410058
8	MAP4K2	2.15884355
9	NUAK1	2.09018368
10	MKNK2	2.05554534
11	MAP2K7	1.97449357
12	SRPK1	1.91662741
13	MKNK1	1.89422541
14	ERBB3	1.82548031
15	ZAK	1.76334381
16	CSNK1G1	1.66911680
17	DYRK2	1.65499427
18	PINK1	1.61158267
19	TNIK	1.57323983
20	ACVR1B	1.56000568
21	EPHA4	1.54744751
22	EPHA3	1.53155367
23	CSNK1G2	1.53023561
24	CSNK1G3	1.49395969
25	PNCK	1.47096904
26	ADRBK2	1.44717231
27	PLK3	1.43984848
28	STK38L	1.43427879
29	CSNK1A1L	1.40590517
30	MARK1	1.39547738
31	FGFR2	1.34725841
32	PLK2	1.28175116
33	DYRK3	1.27811998
34	MAPK13	1.26972023
35	CDC7	1.25975593
36	STK39	1.20827409
37	GRK1	1.19852147
38	BCKDK	1.15304073
39	PBK	1.14953144
40	TSSK6	1.14188738
41	PAK3	1.11344000
42	WNK4	1.10397411
43	NEK1	1.07707851
44	PRKCE	1.01631627
45	EIF2AK3	1.00961762
46	VRK1	0.99280115
47	TGFBR1	0.98117983
48	WEE1	0.97938905
49	PLK4	0.96166380
50	OXSR1	0.95185867
51	BRSK2	0.94021407
52	INSRR	0.93957861
53	NTRK2	0.91653878
54	RPS6KA4	0.90968978
55	PLK1	0.90683185
56	PRKCG	0.88503719
57	STK3	0.87011080
58	LATS1	0.82913398
59	BUB1	0.82307421
60	BRD4	0.81507768
61	TTK	0.80044941
62	STK16	0.78833404
63	MINK1	0.73848341
64	ATM	0.67939669
65	CCNB1	0.67470487
66	ATR	0.66767369
67	ERBB4	0.65412513
68	TIE1	0.65378613
69	FGFR1	0.64045192
70	FLT3	0.61868057
71	NLK	0.61273364
72	VRK2	0.60783880
73	AKT3	0.60291143
74	CDK19	0.58051056
75	NEK2	0.54181667
76	CHEK2	0.50753009
77	TAF1	0.50561248
78	EIF2AK1	0.49199899
79	DYRK1A	0.48012525
80	EPHB2	0.47188176
81	CSNK1A1	0.46984462
82	MAP2K4	0.46744737
83	PASK	0.46630418
84	AURKB	0.44637689
85	CSNK1D	0.43676429
86	RPS6KA5	0.42821149
87	TLK1	0.42281598
88	NTRK3	0.40459318
89	CSNK1E	0.40321246
90	CAMK2A	0.39999668
91	KSR1	0.36479075
92	FER	0.36452975
93	PAK6	0.35738254
94	SGK2	0.35658339
95	EIF2AK2	0.35266692
96	PRKDC	0.34116987
97	SGK223	0.33182357
98	SGK494	0.33182357
99	PRKACB	0.33162847
100	STK11	0.30269834

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.32321422
2	Steroid biosynthesis_Homo sapiens_hsa00100	2.91166515
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.88756140
4	Protein export_Homo sapiens_hsa03060	2.78790562
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.52682361
6	Butanoate metabolism_Homo sapiens_hsa00650	2.31889691
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.19036950
8	Propanoate metabolism_Homo sapiens_hsa00640	2.18185225
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10693295
10	Basal transcription factors_Homo sapiens_hsa03022	2.06008042
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.96960540
12	Homologous recombination_Homo sapiens_hsa03440	1.94897948
13	RNA polymerase_Homo sapiens_hsa03020	1.94463294
14	Phototransduction_Homo sapiens_hsa04744	1.85592416
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85437008
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.83691582
17	Nicotine addiction_Homo sapiens_hsa05033	1.79765120
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.78358766
19	RNA degradation_Homo sapiens_hsa03018	1.72040534
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.57884136
21	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.55941862
22	Mismatch repair_Homo sapiens_hsa03430	1.54225080
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.49247677
24	RNA transport_Homo sapiens_hsa03013	1.43581116
25	Parkinsons disease_Homo sapiens_hsa05012	1.37881306
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.37145792
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.30038006
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24788493
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22699725
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21330713
31	Peroxisome_Homo sapiens_hsa04146	1.21223455
32	Proteasome_Homo sapiens_hsa03050	1.20591793
33	Caffeine metabolism_Homo sapiens_hsa00232	1.20167634
34	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.19877091
35	Fatty acid elongation_Homo sapiens_hsa00062	1.19439563
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.18951316
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.18403431
38	Spliceosome_Homo sapiens_hsa03040	1.14752156
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13024496
40	Base excision repair_Homo sapiens_hsa03410	1.11825784
41	Basal cell carcinoma_Homo sapiens_hsa05217	1.10868764
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.08052571
43	Huntingtons disease_Homo sapiens_hsa05016	1.06235540
44	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.06052242
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.03762688
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.03481903
47	Hippo signaling pathway_Homo sapiens_hsa04390	1.03450406
48	Taste transduction_Homo sapiens_hsa04742	1.00703594
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.99136841
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95270187
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94687224
52	One carbon pool by folate_Homo sapiens_hsa00670	0.93709652
53	GABAergic synapse_Homo sapiens_hsa04727	0.92617235
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.90380753
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87520334
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.82931500
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.82876154
58	Purine metabolism_Homo sapiens_hsa00230	0.81791498
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.81373298
60	Cell cycle_Homo sapiens_hsa04110	0.80960433
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79286830
62	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.77978473
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77921018
64	mRNA surveillance pathway_Homo sapiens_hsa03015	0.76094160
65	Axon guidance_Homo sapiens_hsa04360	0.72862460
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71130370
67	Morphine addiction_Homo sapiens_hsa05032	0.69485066
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68178253
69	Alzheimers disease_Homo sapiens_hsa05010	0.68040592
70	DNA replication_Homo sapiens_hsa03030	0.66504463
71	Olfactory transduction_Homo sapiens_hsa04740	0.66381867
72	Regulation of autophagy_Homo sapiens_hsa04140	0.66200406
73	Oocyte meiosis_Homo sapiens_hsa04114	0.65209886
74	Circadian rhythm_Homo sapiens_hsa04710	0.64914854
75	Metabolic pathways_Homo sapiens_hsa01100	0.64165657
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.63648097
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.61966947
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.61349031
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.60437417
80	Retinol metabolism_Homo sapiens_hsa00830	0.60366189
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59910189
82	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59885688
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58504742
84	Wnt signaling pathway_Homo sapiens_hsa04310	0.56450213
85	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56143983
86	Circadian entrainment_Homo sapiens_hsa04713	0.53682790
87	p53 signaling pathway_Homo sapiens_hsa04115	0.52292491
88	Lysine degradation_Homo sapiens_hsa00310	0.51741714
89	Serotonergic synapse_Homo sapiens_hsa04726	0.49097096
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48697390
91	Fatty acid degradation_Homo sapiens_hsa00071	0.46564033
92	Alcoholism_Homo sapiens_hsa05034	0.45725192
93	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.44984857
94	Insulin secretion_Homo sapiens_hsa04911	0.44935172
95	Cocaine addiction_Homo sapiens_hsa05030	0.44662112
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42964951
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41482026
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36006071
99	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35354560
100	Folate biosynthesis_Homo sapiens_hsa00790	0.33482267

ZNF260

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »