ZNF263

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.17064870
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.06833868
3histone H3-K36 demethylation (GO:0070544)4.05946280
4spliceosomal tri-snRNP complex assembly (GO:0000244)4.04211899
5dosage compensation (GO:0007549)3.96841891
6regulation of chromatin binding (GO:0035561)3.84626218
7regulation of RNA export from nucleus (GO:0046831)3.82798335
8regulation of NFAT protein import into nucleus (GO:0051532)3.80431264
9nuclear pore complex assembly (GO:0051292)3.73806869
10activation of MAPKKK activity (GO:0000185)3.59211033
11regulation of translational fidelity (GO:0006450)3.52465030
123-UTR-mediated mRNA stabilization (GO:0070935)3.50700279
13regulation of nucleobase-containing compound transport (GO:0032239)3.50053040
14embryonic process involved in female pregnancy (GO:0060136)3.41140865
15proline biosynthetic process (GO:0006561)3.40671223
16DNA synthesis involved in DNA repair (GO:0000731)3.31596791
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.27360823
18mRNA stabilization (GO:0048255)3.26741814
19RNA stabilization (GO:0043489)3.26741814
20COPI coating of Golgi vesicle (GO:0048205)3.22441922
21Golgi transport vesicle coating (GO:0048200)3.22441922
22negative regulation of mRNA processing (GO:0050686)3.19138286
23mitotic chromosome condensation (GO:0007076)3.09395398
24DNA unwinding involved in DNA replication (GO:0006268)3.08806514
25response to laminar fluid shear stress (GO:0034616)3.02105408
26cellular protein complex localization (GO:0034629)3.01650885
27negative regulation of mRNA metabolic process (GO:1903312)2.98979594
28ribosomal small subunit biogenesis (GO:0042274)2.90403683
29protein export from nucleus (GO:0006611)2.88888078
30histone lysine demethylation (GO:0070076)2.88447512
31trophectodermal cell differentiation (GO:0001829)2.87791759
32histone demethylation (GO:0016577)2.87005219
33glucocorticoid receptor signaling pathway (GO:0042921)2.86647763
34negative regulation of RNA splicing (GO:0033119)2.85745772
35nuclear pore organization (GO:0006999)2.82314194
36negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.82194180
37apoptotic process involved in morphogenesis (GO:0060561)2.81393072
38protein complex localization (GO:0031503)2.79704197
39pore complex assembly (GO:0046931)2.79499163
40negative regulation of histone methylation (GO:0031061)2.77885503
41NIK/NF-kappaB signaling (GO:0038061)2.75036417
42positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.75017298
43response to muramyl dipeptide (GO:0032495)2.73595408
44positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.73499534
45stress granule assembly (GO:0034063)2.70152818
46epithelial cell differentiation involved in prostate gland development (GO:0060742)2.69584448
47histone H3-K9 demethylation (GO:0033169)2.68844650
48intracellular estrogen receptor signaling pathway (GO:0030520)2.67603036
49regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64881249
50maturation of SSU-rRNA (GO:0030490)2.63754625
51histone H2B ubiquitination (GO:0033523)2.63645253
52activation of Rac GTPase activity (GO:0032863)2.62787357
53mannose metabolic process (GO:0006013)2.61300197
54positive regulation of p38MAPK cascade (GO:1900745)2.60399931
55modulation by symbiont of host cellular process (GO:0044068)2.59235292
56protein localization to endosome (GO:0036010)2.57145888
57positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55785313
58DNA duplex unwinding (GO:0032508)2.54907736
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.54122170
60response to peptidoglycan (GO:0032494)2.52641728
61poly(A)+ mRNA export from nucleus (GO:0016973)2.50859024
62cellular hyperosmotic response (GO:0071474)2.49631908
63mitotic sister chromatid cohesion (GO:0007064)2.48151376
64regulation of RNA stability (GO:0043487)2.45585064
65corticosteroid receptor signaling pathway (GO:0031958)2.45394600
66stress fiber assembly (GO:0043149)2.44383759
67peptidyl-lysine dimethylation (GO:0018027)2.43973489
68maternal placenta development (GO:0001893)2.43896865
69adherens junction assembly (GO:0034333)2.42937498
70protein demethylation (GO:0006482)2.42692187
71protein dealkylation (GO:0008214)2.42692187
72positive regulation of gamma-delta T cell activation (GO:0046645)2.40812024
73regulation of mRNA stability (GO:0043488)2.40786059
74positive regulation of protein homooligomerization (GO:0032464)2.40448238
75negative regulation of fatty acid biosynthetic process (GO:0045717)2.40177687
76regulation of DNA methylation (GO:0044030)2.39066482
77negative regulation of necroptotic process (GO:0060546)2.38026777
78positive regulation of keratinocyte differentiation (GO:0045618)2.36506826
79modulation by virus of host process (GO:0019054)2.36353407
80rRNA transcription (GO:0009303)2.34937256
81mitochondrial fusion (GO:0008053)2.34653064
82mitochondrial DNA metabolic process (GO:0032042)2.33140813
83activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.32843980
84retrograde transport, endosome to Golgi (GO:0042147)2.32466714
85negative regulation of toll-like receptor signaling pathway (GO:0034122)2.32347084
86cellular response to virus (GO:0098586)2.32218815
87activation of JUN kinase activity (GO:0007257)2.31887581
88positive regulation of nuclease activity (GO:0032075)2.31303489
89DNA geometric change (GO:0032392)2.31072491
90pinocytosis (GO:0006907)2.28748129
91focal adhesion assembly (GO:0048041)2.25716349
92cell-substrate adherens junction assembly (GO:0007045)2.25716349
93regulation of histone methylation (GO:0031060)2.25440788
94ribosome biogenesis (GO:0042254)2.23814291
95mRNA transcription from RNA polymerase II promoter (GO:0042789)2.23537858
96pentose-phosphate shunt (GO:0006098)2.23410588
97nucleosome disassembly (GO:0006337)2.22701540
98protein-DNA complex disassembly (GO:0032986)2.22701540
99histone H4-K16 acetylation (GO:0043984)2.21752995
100retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.20599607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.57318558
2MYC_22102868_ChIP-Seq_BL_Human3.55742623
3VDR_21846776_ChIP-Seq_THP-1_Human3.47867233
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.94275235
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77117403
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50298022
7* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37004811
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.22233418
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.21979958
10TCF7_22412390_ChIP-Seq_EML_Mouse2.18381648
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11804072
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07294178
13DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04563428
14CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.03131368
15KDM2B_26808549_Chip-Seq_DND41_Human2.03121719
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.02140967
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.96490572
18LXR_22292898_ChIP-Seq_THP-1_Human1.91694518
19ZNF263_19887448_ChIP-Seq_K562_Human1.85924186
20XRN2_22483619_ChIP-Seq_HELA_Human1.84730523
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84323544
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84252299
23RACK7_27058665_Chip-Seq_MCF-7_Human1.80680935
24CIITA_25753668_ChIP-Seq_RAJI_Human1.79175454
25MAF_26560356_Chip-Seq_TH1_Human1.75270756
26VDR_24763502_ChIP-Seq_THP-1_Human1.73823019
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59096571
28* UTX_26944678_Chip-Seq_JUKART_Human1.58496876
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58063753
30* MAF_26560356_Chip-Seq_TH2_Human1.57661741
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57512141
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56001066
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55139041
34CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.53790767
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45367441
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44790461
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44542352
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44337266
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.41326984
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.40868092
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40682154
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38889012
43KDM2B_26808549_Chip-Seq_K562_Human1.38611337
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37506737
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36198784
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36090189
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36001312
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35018930
49CLOCK_20551151_ChIP-Seq_293T_Human1.33613728
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33225144
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30931482
52NCOR1_26117541_ChIP-Seq_K562_Human1.30366469
53TFEB_21752829_ChIP-Seq_HELA_Human1.28221794
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27672297
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27635407
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27542305
57DCP1A_22483619_ChIP-Seq_HELA_Human1.25326276
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25229867
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23998275
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23842553
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.23635773
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23057926
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.22498997
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21325963
65P68_20966046_ChIP-Seq_HELA_Human1.21192301
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20298123
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20240459
68PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20213102
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19884837
70CREB1_26743006_Chip-Seq_LNCaP_Human1.18196689
71ATF3_27146783_Chip-Seq_COLON_Human1.17645021
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17565739
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16692216
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16365630
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16351057
76* NOTCH1_21737748_ChIP-Seq_TLL_Human1.16099684
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14233271
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14192848
79* KDM5A_27292631_Chip-Seq_BREAST_Human1.13266354
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12773323
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12330570
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11294659
83CHD1_26751641_Chip-Seq_LNCaP_Human1.11273185
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10038865
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09061732
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.08186399
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08095323
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06852791
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06449140
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05636274
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05554174
92SMC4_20622854_ChIP-Seq_HELA_Human1.05168597
93GABP_19822575_ChIP-Seq_HepG2_Human1.05093145
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04715553
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03888087
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03404538
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01637386
98STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01576761
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.01418692
100TP53_22127205_ChIP-Seq_IMR90_Human1.00600690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.10514695
2MP0009278_abnormal_bone_marrow2.97297804
3MP0003705_abnormal_hypodermis_morpholog2.76050914
4MP0008057_abnormal_DNA_replication2.75740811
5MP0003111_abnormal_nucleus_morphology2.68874484
6MP0003693_abnormal_embryo_hatching2.36218126
7MP0008260_abnormal_autophagy2.35340491
8MP0004185_abnormal_adipocyte_glucose2.33607057
9MP0003303_peritoneal_inflammation2.31917626
10MP0004264_abnormal_extraembryonic_tissu2.15344311
11MP0005058_abnormal_lysosome_morphology2.08466547
12MP0005451_abnormal_body_composition2.02075436
13MP0003763_abnormal_thymus_physiology1.99974097
14MP0002396_abnormal_hematopoietic_system1.99639040
15MP0003077_abnormal_cell_cycle1.99481235
16MP0003453_abnormal_keratinocyte_physiol1.99315077
17MP0001545_abnormal_hematopoietic_system1.99238644
18MP0005397_hematopoietic_system_phenotyp1.99238644
19MP0004808_abnormal_hematopoietic_stem1.96325269
20MP0009840_abnormal_foam_cell1.91553178
21MP0004233_abnormal_muscle_weight1.90448354
22MP0002877_abnormal_melanocyte_morpholog1.88955511
23MP0003123_paternal_imprinting1.79593663
24MP0004957_abnormal_blastocyst_morpholog1.79257542
25MP0000350_abnormal_cell_proliferation1.72371951
26MP0003191_abnormal_cellular_cholesterol1.67993802
27MP0002009_preneoplasia1.67843518
28MP0009333_abnormal_splenocyte_physiolog1.67827950
29MP0001730_embryonic_growth_arrest1.59144717
30MP0001849_ear_inflammation1.57361818
31MP0003091_abnormal_cell_migration1.54431073
32MP0003436_decreased_susceptibility_to1.54316704
33MP0010307_abnormal_tumor_latency1.53380508
34MP0010094_abnormal_chromosome_stability1.50053194
35MP0003221_abnormal_cardiomyocyte_apopto1.49615192
36MP0000703_abnormal_thymus_morphology1.40335556
37MP0002398_abnormal_bone_marrow1.35301271
38MP0000313_abnormal_cell_death1.34946452
39MP0004947_skin_inflammation1.33110965
40MP0003300_gastrointestinal_ulcer1.30465893
41MP0003984_embryonic_growth_retardation1.30366012
42MP0005621_abnormal_cell_physiology1.29700129
43MP0008007_abnormal_cellular_replicative1.28082452
44MP0005666_abnormal_adipose_tissue1.26389329
45MP0002080_prenatal_lethality1.25178596
46MP0000490_abnormal_crypts_of1.23829052
47MP0005380_embryogenesis_phenotype1.23300861
48MP0001672_abnormal_embryogenesis/_devel1.23300861
49MP0002086_abnormal_extraembryonic_tissu1.23127032
50MP0005501_abnormal_skin_physiology1.22573951
51MP0002088_abnormal_embryonic_growth/wei1.21564594
52MP0004782_abnormal_surfactant_physiolog1.19498417
53MP0002089_abnormal_postnatal_growth/wei1.17139173
54MP0004858_abnormal_nervous_system1.16718929
55MP0003656_abnormal_erythrocyte_physiolo1.14287621
56MP0002722_abnormal_immune_system1.12222343
57MP0005384_cellular_phenotype1.10783343
58MP0002796_impaired_skin_barrier1.09476738
59MP0001697_abnormal_embryo_size1.09238868
60MP0003566_abnormal_cell_adhesion1.06254582
61MP0000858_altered_metastatic_potential1.05478482
62MP0002429_abnormal_blood_cell1.04354669
63MP0002019_abnormal_tumor_incidence1.03440509
64MP0000716_abnormal_immune_system1.03301171
65MP0001661_extended_life_span1.02368803
66MP0000537_abnormal_urethra_morphology1.01868588
67MP0005409_darkened_coat_color1.00971800
68MP0002420_abnormal_adaptive_immunity1.00305822
69MP0002405_respiratory_system_inflammati1.00058041
70MP0009672_abnormal_birth_weight0.99811749
71MP0010352_gastrointestinal_tract_polyps0.98334686
72MP0001819_abnormal_immune_cell0.97862983
73MP0001800_abnormal_humoral_immune0.96528631
74MP0005375_adipose_tissue_phenotype0.96456409
75MP0010630_abnormal_cardiac_muscle0.96435725
76MP0000689_abnormal_spleen_morphology0.95360731
77MP0002419_abnormal_innate_immunity0.94402458
78MP0002452_abnormal_antigen_presenting0.93410477
79MP0005000_abnormal_immune_tolerance0.92628066
80MP0000358_abnormal_cell_content/0.91933470
81MP0002723_abnormal_immune_serum0.91290666
82MP0000747_muscle_weakness0.90285503
83MP0004197_abnormal_fetal_growth/weight/0.89870950
84MP0001853_heart_inflammation0.87652954
85MP0009931_abnormal_skin_appearance0.86501899
86MP0000733_abnormal_muscle_development0.86396375
87MP0000678_abnormal_parathyroid_gland0.85541116
88MP0002084_abnormal_developmental_patter0.84600219
89MP0003329_amyloid_beta_deposits0.82909440
90MP0005025_abnormal_response_to0.82154280
91MP0002085_abnormal_embryonic_tissue0.81772403
92MP0002998_abnormal_bone_remodeling0.79589809
93MP0003172_abnormal_lysosome_physiology0.78996258
94MP0008058_abnormal_DNA_repair0.78777837
95MP0001790_abnormal_immune_system0.78359608
96MP0005387_immune_system_phenotype0.78359608
97MP0000003_abnormal_adipose_tissue0.77719882
98MP0004381_abnormal_hair_follicle0.76795212
99MP0001915_intracranial_hemorrhage0.76273413
100MP0008995_early_reproductive_senescence0.75472609

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.56135751
2Microvesicular hepatic steatosis (HP:0001414)3.27693997
3Ragged-red muscle fibers (HP:0003200)3.19269137
4Progressive external ophthalmoplegia (HP:0000590)3.18649362
5Progressive muscle weakness (HP:0003323)3.13166719
6Abnormality of the fingertips (HP:0001211)3.10395802
7Syringomyelia (HP:0003396)3.06944755
8Spinal cord lesions (HP:0100561)3.06944755
9Ulnar bowing (HP:0003031)2.79404556
10Thin bony cortex (HP:0002753)2.72496258
11Insomnia (HP:0100785)2.66633823
12Sparse lateral eyebrow (HP:0005338)2.65318914
13Slow saccadic eye movements (HP:0000514)2.64618499
14Cellulitis (HP:0100658)2.62347191
15Abnormality of the distal phalanx of the thumb (HP:0009617)2.52140046
16Abnormality of the thoracic spine (HP:0100711)2.39428399
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39383041
18Deep palmar crease (HP:0006191)2.35223096
19Long palpebral fissure (HP:0000637)2.32875765
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30217753
21Thoracic kyphosis (HP:0002942)2.30207108
22Eczematoid dermatitis (HP:0000976)2.25599126
23Achilles tendon contracture (HP:0001771)2.25331409
24Dysmetric saccades (HP:0000641)2.24771197
25Hypercortisolism (HP:0001578)2.21396309
26Chromsome breakage (HP:0040012)2.18457431
27Fatigue (HP:0012378)2.17122998
28Basal cell carcinoma (HP:0002671)2.17043355
29Colitis (HP:0002583)2.12494119
30Overriding aorta (HP:0002623)2.11852487
31Multiple enchondromatosis (HP:0005701)2.09999927
32Abnormality of the phalanges of the hallux (HP:0010057)2.09537782
33Upper motor neuron abnormality (HP:0002127)2.07250972
34Reticulocytopenia (HP:0001896)2.07216219
35Broad distal phalanx of finger (HP:0009836)2.00015019
36Patellar dislocation (HP:0002999)1.98839966
37Ankyloglossia (HP:0010296)1.98246567
38Mediastinal lymphadenopathy (HP:0100721)1.96988474
39Dislocated radial head (HP:0003083)1.96362119
40Vertebral compression fractures (HP:0002953)1.92213603
41Turricephaly (HP:0000262)1.90223041
42Ureteral duplication (HP:0000073)1.89635016
43Squamous cell carcinoma (HP:0002860)1.86148884
44Pointed chin (HP:0000307)1.85563001
45Germ cell neoplasia (HP:0100728)1.85161276
46Elfin facies (HP:0004428)1.83324606
47Abnormality of the Achilles tendon (HP:0005109)1.81496378
48Neuronal loss in central nervous system (HP:0002529)1.81349398
49Hypertensive crisis (HP:0100735)1.80668661
50Gastrointestinal inflammation (HP:0004386)1.79114790
51Abnormality of the radial head (HP:0003995)1.77314858
52Thrombocytosis (HP:0001894)1.72536098
53Recurrent viral infections (HP:0004429)1.71898101
54Mitral regurgitation (HP:0001653)1.69959060
55Obstructive sleep apnea (HP:0002870)1.69461359
56Dysphonia (HP:0001618)1.67938584
57Viral hepatitis (HP:0006562)1.66617007
58Broad face (HP:0000283)1.66116433
59Flat acetabular roof (HP:0003180)1.66011022
60Abnormality of the columella (HP:0009929)1.65924628
61Segmental peripheral demyelination/remyelination (HP:0003481)1.64982669
62External ophthalmoplegia (HP:0000544)1.64138371
63Gastrointestinal stroma tumor (HP:0100723)1.63997178
64Abnormality of oral frenula (HP:0000190)1.62806333
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62672447
66Hyperparathyroidism (HP:0000843)1.62670269
6711 pairs of ribs (HP:0000878)1.62359590
68Poikiloderma (HP:0001029)1.61571924
69Trismus (HP:0000211)1.60460849
70Abnormality of the gastric mucosa (HP:0004295)1.59559464
71Interstitial pulmonary disease (HP:0006530)1.59524444
72Cerebral inclusion bodies (HP:0100314)1.59212033
73Thin ribs (HP:0000883)1.58588488
74Absent radius (HP:0003974)1.58467869
75Duplication of thumb phalanx (HP:0009942)1.58199290
76Vertebral arch anomaly (HP:0008438)1.57798303
77Testicular atrophy (HP:0000029)1.57430927
78Metaphyseal cupping (HP:0003021)1.57145448
79Renovascular hypertension (HP:0100817)1.57055775
80Flat cornea (HP:0007720)1.55867582
81Renal duplication (HP:0000075)1.54542664
82Long eyelashes (HP:0000527)1.53834704
83Arnold-Chiari malformation (HP:0002308)1.50881726
84Genu recurvatum (HP:0002816)1.50304616
85Asymmetry of the thorax (HP:0001555)1.49597305
86Heterotopia (HP:0002282)1.49330980
87Disproportionate tall stature (HP:0001519)1.48544683
88Abnormal large intestine physiology (HP:0012700)1.48497724
89Myopathic facies (HP:0002058)1.48088443
90Spina bifida occulta (HP:0003298)1.47817471
91Bowel incontinence (HP:0002607)1.47263521
92Recurrent bacterial skin infections (HP:0005406)1.47108738
93Persistence of primary teeth (HP:0006335)1.45583506
94Abnormality of DNA repair (HP:0003254)1.44183604
95Inflammation of the large intestine (HP:0002037)1.43499615
96Abnormality of the parietal bone (HP:0002696)1.42935544
97Missing ribs (HP:0000921)1.42807344
98Obsessive-compulsive behavior (HP:0000722)1.42713990
99Flared metaphyses (HP:0003015)1.41646112
100Increased serum ferritin (HP:0003281)1.41498606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.25329557
2TRIB33.68522954
3CDK123.60254869
4EEF2K2.91625852
5NME22.87308000
6SMG12.81031425
7MAP3K102.54364472
8ICK2.39668665
9SIK12.21804350
10MAP4K12.04720577
11IRAK32.04698386
12SCYL21.83741334
13ERN11.81057711
14BRD41.61221819
15KSR21.55301371
16MAP3K131.45081635
17TAOK21.42246128
18MTOR1.30984963
19CDK41.28417345
20MAP3K141.27912346
21MAP2K31.25807542
22MAPK111.25754332
23SIK21.24433601
24LATS21.23485763
25RIPK41.21562721
26FGFR41.19227778
27MARK21.18381779
28SRPK11.11762342
29PIM21.11513510
30CDK61.09764216
31MAP3K11.09505790
32RAF11.08981242
33TAOK11.02842823
34RPS6KB21.02504214
35MAP3K111.02478783
36RPS6KC11.02004182
37RPS6KL11.02004182
38TBK11.00481694
39PDGFRA0.93684382
40RIPK10.93250681
41CAMK1D0.88711528
42PBK0.86999077
43CDC70.84150870
44PIM10.83427572
45BMX0.79699773
46MAP3K80.77776521
47BLK0.77638178
48IRAK40.76316423
49PDK20.76277504
50CDC42BPA0.75453022
51PKN20.74256888
52TESK20.73367723
53PDPK10.73335920
54RPS6KA60.73187343
55RPS6KA10.71225322
56RPS6KA20.69701706
57PASK0.69555855
58DYRK1B0.68977390
59TYRO30.66975785
60CHEK10.66560065
61IRAK20.66185116
62PRKD20.64661387
63LRRK20.64620258
64CAMK1G0.63907338
65MAP3K20.63697737
66JAK30.62952851
67CDK70.62086382
68MAP3K30.62036356
69CSK0.60941394
70AURKA0.60216858
71IKBKE0.59614023
72ATR0.59483835
73MAP2K20.58978253
74YES10.58382571
75TTN0.57660123
76FGFR30.57447246
77CLK10.56762766
78PTK60.55696684
79PAK40.53720982
80ARAF0.53422445
81BTK0.52532529
82PAK20.52203775
83MOS0.52031820
84RPS6KB10.50958537
85PDGFRB0.50942827
86CDK20.49804152
87CHUK0.49211906
88SIK30.49077436
89ZAP700.49054214
90HCK0.47536985
91ALK0.47418635
92MAP3K90.46332675
93JAK20.45927258
94PDK10.44999243
95HIPK20.44013317
96MAP3K50.44012232
97RET0.42857850
98KSR10.42500303
99IKBKB0.42272970
100BRAF0.40715745

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.24447893
2Chronic myeloid leukemia_Homo sapiens_hsa052202.15962169
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09147351
4B cell receptor signaling pathway_Homo sapiens_hsa046622.08298745
5Other glycan degradation_Homo sapiens_hsa005112.02008931
6Non-small cell lung cancer_Homo sapiens_hsa052231.90017046
7Bladder cancer_Homo sapiens_hsa052191.68648951
8Notch signaling pathway_Homo sapiens_hsa043301.63951544
9Pancreatic cancer_Homo sapiens_hsa052121.62081826
10mTOR signaling pathway_Homo sapiens_hsa041501.57078529
11Endometrial cancer_Homo sapiens_hsa052131.51730543
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51029453
13Hepatitis B_Homo sapiens_hsa051611.49245028
14mRNA surveillance pathway_Homo sapiens_hsa030151.49241653
15Spliceosome_Homo sapiens_hsa030401.47647262
16DNA replication_Homo sapiens_hsa030301.47178396
17Neurotrophin signaling pathway_Homo sapiens_hsa047221.46970775
18Viral carcinogenesis_Homo sapiens_hsa052031.46547097
19VEGF signaling pathway_Homo sapiens_hsa043701.44370629
20Base excision repair_Homo sapiens_hsa034101.42838959
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.40371411
22Colorectal cancer_Homo sapiens_hsa052101.34815986
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33533282
24Renal cell carcinoma_Homo sapiens_hsa052111.33140055
25ErbB signaling pathway_Homo sapiens_hsa040121.32702692
26Apoptosis_Homo sapiens_hsa042101.31942015
27Osteoclast differentiation_Homo sapiens_hsa043801.29828062
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29779371
29Thyroid cancer_Homo sapiens_hsa052161.28842759
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27291114
31MicroRNAs in cancer_Homo sapiens_hsa052061.23690540
32Prolactin signaling pathway_Homo sapiens_hsa049171.22447455
33Herpes simplex infection_Homo sapiens_hsa051681.20523374
34Cell cycle_Homo sapiens_hsa041101.19097570
35Prostate cancer_Homo sapiens_hsa052151.18030412
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16820867
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15136818
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.14066457
39T cell receptor signaling pathway_Homo sapiens_hsa046601.12754504
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.10571258
41HTLV-I infection_Homo sapiens_hsa051661.09690644
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09256015
43TNF signaling pathway_Homo sapiens_hsa046681.08673304
44Influenza A_Homo sapiens_hsa051641.08466611
45Small cell lung cancer_Homo sapiens_hsa052221.05563306
46Inositol phosphate metabolism_Homo sapiens_hsa005621.02586451
47Hepatitis C_Homo sapiens_hsa051601.01591035
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99834404
49Sulfur relay system_Homo sapiens_hsa041220.99616863
50Measles_Homo sapiens_hsa051620.98163140
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98154348
52FoxO signaling pathway_Homo sapiens_hsa040680.98086526
53Leishmaniasis_Homo sapiens_hsa051400.97882783
54Glioma_Homo sapiens_hsa052140.97069361
55RNA transport_Homo sapiens_hsa030130.97056132
56Epstein-Barr virus infection_Homo sapiens_hsa051690.96775993
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96316015
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94655276
59Insulin signaling pathway_Homo sapiens_hsa049100.92381348
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.90928125
61Systemic lupus erythematosus_Homo sapiens_hsa053220.89227662
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89108593
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87867005
64Prion diseases_Homo sapiens_hsa050200.86532892
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86264816
66Lysine degradation_Homo sapiens_hsa003100.86241666
67Toxoplasmosis_Homo sapiens_hsa051450.85531183
68Choline metabolism in cancer_Homo sapiens_hsa052310.84250723
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.82372297
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.81199819
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.79361972
72Pentose phosphate pathway_Homo sapiens_hsa000300.78846997
73Tuberculosis_Homo sapiens_hsa051520.77992739
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70766618
75Fructose and mannose metabolism_Homo sapiens_hsa000510.70555597
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70528178
77Insulin resistance_Homo sapiens_hsa049310.70175960
78Endocytosis_Homo sapiens_hsa041440.69198025
79Shigellosis_Homo sapiens_hsa051310.67185506
80MAPK signaling pathway_Homo sapiens_hsa040100.66824130
81HIF-1 signaling pathway_Homo sapiens_hsa040660.66358175
82GnRH signaling pathway_Homo sapiens_hsa049120.66040299
83Viral myocarditis_Homo sapiens_hsa054160.65156272
84AMPK signaling pathway_Homo sapiens_hsa041520.65039443
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64587937
86Lysosome_Homo sapiens_hsa041420.63660524
87Alcoholism_Homo sapiens_hsa050340.63257402
88p53 signaling pathway_Homo sapiens_hsa041150.62995880
89Biosynthesis of amino acids_Homo sapiens_hsa012300.62852222
90Estrogen signaling pathway_Homo sapiens_hsa049150.62318920
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.62263736
92Adherens junction_Homo sapiens_hsa045200.62232009
93Proteoglycans in cancer_Homo sapiens_hsa052050.62224771
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59570943
95Type II diabetes mellitus_Homo sapiens_hsa049300.57851354
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55480839
97Long-term potentiation_Homo sapiens_hsa047200.55415389
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53318931
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.52447580
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50593994

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