ZNF267

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.30568951
2negative regulation of interleukin-12 production (GO:0032695)4.79483218
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.68039695
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.68039695
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.68039695
6modulation by symbiont of host immune response (GO:0052553)4.68039695
7positive regulation by symbiont of host defense response (GO:0052509)4.68039695
8modulation by symbiont of host defense response (GO:0052031)4.68039695
9response to peptidoglycan (GO:0032494)4.53877519
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.41835830
11macrophage activation involved in immune response (GO:0002281)4.20276698
12detection of molecule of bacterial origin (GO:0032490)4.18712913
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.16297058
14regulation of B cell receptor signaling pathway (GO:0050855)4.08807685
15cellular extravasation (GO:0045123)3.95528105
16regulation of interferon-beta biosynthetic process (GO:0045357)3.91715027
17regulation of gamma-delta T cell activation (GO:0046643)3.84305624
18negative regulation of cell killing (GO:0031342)3.82166879
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.82166879
20neutrophil activation involved in immune response (GO:0002283)3.78858263
21regulation of interferon-alpha production (GO:0032647)3.68941287
22immunoglobulin mediated immune response (GO:0016064)3.67879922
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.65868009
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65604464
25T cell migration (GO:0072678)3.63145705
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.62341016
27detection of other organism (GO:0098543)3.58124153
28positive regulation of interferon-alpha production (GO:0032727)3.56421737
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.56307220
30NIK/NF-kappaB signaling (GO:0038061)3.50762586
31type I interferon signaling pathway (GO:0060337)3.49171041
32cellular response to type I interferon (GO:0071357)3.49171041
33T-helper 1 type immune response (GO:0042088)3.48493795
34response to type I interferon (GO:0034340)3.45573393
35detection of external biotic stimulus (GO:0098581)3.39508914
36defense response to protozoan (GO:0042832)3.37825785
37regulation of vitamin D biosynthetic process (GO:0060556)3.36946304
38regulation of T-helper 1 cell differentiation (GO:0045625)3.36090833
39B cell mediated immunity (GO:0019724)3.32321136
40interferon-gamma-mediated signaling pathway (GO:0060333)3.30133927
41response to protozoan (GO:0001562)3.29067069
42microglial cell activation (GO:0001774)3.28422588
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.27438539
44response to host immune response (GO:0052572)3.27438539
45regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.22649537
46regulation of interleukin-12 biosynthetic process (GO:0045075)3.22604852
47myeloid cell activation involved in immune response (GO:0002275)3.21289964
48germinal center formation (GO:0002467)3.19029168
49myeloid dendritic cell differentiation (GO:0043011)3.18516653
50detection of biotic stimulus (GO:0009595)3.17710120
51negative regulation of T cell mediated immunity (GO:0002710)3.15098827
52macrophage activation (GO:0042116)3.14879299
53regulation of gamma-delta T cell differentiation (GO:0045586)3.11342992
54positive regulation of interferon-beta production (GO:0032728)3.11210925
55detection of bacterium (GO:0016045)3.11141241
56myeloid dendritic cell activation (GO:0001773)3.10810986
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10687916
58regulation of interleukin-12 production (GO:0032655)3.07704358
59response to muramyl dipeptide (GO:0032495)3.05762546
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05271940
61granulocyte activation (GO:0036230)3.05115285
62positive regulation of B cell differentiation (GO:0045579)3.04952742
63regulation of alpha-beta T cell proliferation (GO:0046640)3.01451648
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.98944146
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98662724
66B cell receptor signaling pathway (GO:0050853)2.96805705
67neutrophil mediated immunity (GO:0002446)2.96661559
68antigen processing and presentation of endogenous antigen (GO:0019883)2.93901625
69neutrophil activation (GO:0042119)2.93451596
70response to host (GO:0075136)2.90774869
71response to host defenses (GO:0052200)2.90774869
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90774869
73respiratory burst (GO:0045730)2.89823918
74response to interleukin-15 (GO:0070672)2.88456282
75regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88212437
76antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87996595
77positive regulation of interleukin-2 production (GO:0032743)2.87700204
78regulation of interleukin-2 biosynthetic process (GO:0045076)2.87370082
79tolerance induction (GO:0002507)2.86508246
80positive regulation of type 2 immune response (GO:0002830)2.86229294
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.85179660
82positive regulation of interleukin-10 production (GO:0032733)2.83886789
83positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.83589881
84interferon-gamma production (GO:0032609)2.82161410
85positive regulation of interleukin-12 production (GO:0032735)2.80701323
86production of molecular mediator involved in inflammatory response (GO:0002532)2.79840586
87regulation of chronic inflammatory response (GO:0002676)2.79833454
88regulation of interleukin-8 biosynthetic process (GO:0045414)2.79626608
89positive regulation of NF-kappaB import into nucleus (GO:0042346)2.79609997
90regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78554553
91regulation of T cell tolerance induction (GO:0002664)2.78058113
92positive regulation of cytokine biosynthetic process (GO:0042108)2.76547845
93positive regulation of toll-like receptor signaling pathway (GO:0034123)2.76269730
94myeloid leukocyte activation (GO:0002274)2.75624128
95positive regulation of humoral immune response (GO:0002922)2.75550509
96negative regulation of interleukin-17 production (GO:0032700)2.72425620
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.72345934
98regulation of T-helper cell differentiation (GO:0045622)2.71953011
99regulation of tolerance induction (GO:0002643)2.71497763
100cellular response to interleukin-15 (GO:0071350)2.69310693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.57195304
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.51208989
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.10667738
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.58460260
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.00942895
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.64316192
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.48495598
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.38648994
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.30331405
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.26228336
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21525956
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.08737692
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.03138667
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95748263
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.67429472
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62784559
17* MYB_26560356_Chip-Seq_TH2_Human2.57016092
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.51085614
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50964841
20* SPI1_23547873_ChIP-Seq_NB4_Human2.47376217
21RUNX_20019798_ChIP-Seq_JUKART_Human2.43489830
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.41009634
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.39506351
24* MYB_26560356_Chip-Seq_TH1_Human2.08088312
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07531126
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03446277
27SCL_19346495_ChIP-Seq_HPC-7_Human2.01363825
28GATA1_22025678_ChIP-Seq_K562_Human1.95568958
29VDR_24787735_ChIP-Seq_THP-1_Human1.94373266
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82500057
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80776023
32GATA3_27048872_Chip-Seq_THYMUS_Human1.70603426
33SPI1_23127762_ChIP-Seq_K562_Human1.69867101
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69067298
35GATA3_26560356_Chip-Seq_TH2_Human1.68582837
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66666365
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64686564
38E2F7_22180533_ChIP-Seq_HELA_Human1.64392200
39MAF_26560356_Chip-Seq_TH1_Human1.59888273
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59736188
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59055950
42PU_27001747_Chip-Seq_BMDM_Mouse1.58129059
43VDR_24763502_ChIP-Seq_THP-1_Human1.57802725
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55353234
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53473239
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42700943
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.39027949
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36657157
49TFEB_21752829_ChIP-Seq_HELA_Human1.34474093
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32576156
51MYC_22102868_ChIP-Seq_BL_Human1.31650559
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29028207
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27816597
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22489968
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22028569
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19494560
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18731357
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18451149
59* UTX_26944678_Chip-Seq_JUKART_Human1.15919159
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09821592
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09033550
62VDR_21846776_ChIP-Seq_THP-1_Human1.06012393
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05161871
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04847154
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03942926
66VDR_23849224_ChIP-Seq_CD4+_Human1.03808560
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98454390
68GATA2_21666600_ChIP-Seq_HMVEC_Human0.96997026
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96988658
70* MAF_26560356_Chip-Seq_TH2_Human0.90466868
71SMRT_27268052_Chip-Seq_Bcells_Human0.88946328
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88700844
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84507825
74GATA3_26560356_Chip-Seq_TH1_Human0.81462103
75ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81011726
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80893714
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80059639
78TCF7_22412390_ChIP-Seq_EML_Mouse0.79490436
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79111818
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79102394
81SALL4_22934838_ChIP-ChIP_CD34+_Human0.78576141
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77989276
83ELK1_19687146_ChIP-ChIP_HELA_Human0.77647657
84FLI1_27457419_Chip-Seq_LIVER_Mouse0.76936706
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75692849
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75240628
87FOXM1_23109430_ChIP-Seq_U2OS_Human0.73083511
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71645829
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.71536135
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71151457
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70995839
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70079212
93FOXP3_21729870_ChIP-Seq_TREG_Human0.68721745
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.67309569
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.67309569
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.67309569
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67298049
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.67113039
99GATA2_19941826_ChIP-Seq_K562_Human0.66472030
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.65623186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.18632477
2MP0003724_increased_susceptibility_to3.64452979
3MP0001835_abnormal_antigen_presentation3.57340642
4MP0005671_abnormal_response_to3.17916946
5MP0003436_decreased_susceptibility_to3.14408736
6MP0009785_altered_susceptibility_to3.03802440
7MP0005000_abnormal_immune_tolerance2.89367688
8MP0002148_abnormal_hypersensitivity_rea2.87187525
9MP0001800_abnormal_humoral_immune2.80734820
10MP0005387_immune_system_phenotype2.71237532
11MP0001790_abnormal_immune_system2.71237532
12MP0006082_CNS_inflammation2.68265901
13MP0008057_abnormal_DNA_replication2.67038332
14MP0000685_abnormal_immune_system2.63294896
15MP0002419_abnormal_innate_immunity2.61204822
16MP0002452_abnormal_antigen_presenting2.52499889
17MP0002723_abnormal_immune_serum2.50082950
18MP0005025_abnormal_response_to2.46417977
19MP0002420_abnormal_adaptive_immunity2.25744575
20MP0001819_abnormal_immune_cell2.24000548
21MP0003763_abnormal_thymus_physiology2.13054089
22MP0003300_gastrointestinal_ulcer2.08141316
23MP0002405_respiratory_system_inflammati1.97583220
24MP0004947_skin_inflammation1.90044862
25MP0009764_decreased_sensitivity_to1.88699030
26MP0002398_abnormal_bone_marrow1.83326487
27MP0000716_abnormal_immune_system1.78547315
28MP0001853_heart_inflammation1.78236535
29MP0001845_abnormal_inflammatory_respons1.78214917
30MP0005310_abnormal_salivary_gland1.76021217
31MP0010155_abnormal_intestine_physiology1.75105532
32MP0005451_abnormal_body_composition1.74242046
33MP0009333_abnormal_splenocyte_physiolog1.72014242
34MP0004510_myositis1.67113549
35MP0005464_abnormal_platelet_physiology1.57050948
36MP0000689_abnormal_spleen_morphology1.57036447
37MP0002138_abnormal_hepatobiliary_system1.55127527
38MP0001533_abnormal_skeleton_physiology1.53088217
39MP0002722_abnormal_immune_system1.51618092
40MP0008260_abnormal_autophagy1.50299559
41MP0000569_abnormal_digit_pigmentation1.49375851
42MP0003656_abnormal_erythrocyte_physiolo1.48915185
43MP0005397_hematopoietic_system_phenotyp1.46137902
44MP0001545_abnormal_hematopoietic_system1.46137902
45MP0002429_abnormal_blood_cell1.43221445
46MP0009278_abnormal_bone_marrow1.42578487
47MP0003172_abnormal_lysosome_physiology1.42358657
48MP0008469_abnormal_protein_level1.38803850
49MP0002166_altered_tumor_susceptibility1.38313931
50MP0003828_pulmonary_edema1.35603623
51MP0005058_abnormal_lysosome_morphology1.35014280
52MP0008004_abnormal_stomach_pH1.31535789
53MP0002998_abnormal_bone_remodeling1.30877861
54MP0002006_tumorigenesis1.28214516
55MP0000703_abnormal_thymus_morphology1.26734288
56MP0003448_altered_tumor_morphology1.24609797
57MP0000343_altered_response_to1.22871590
58MP0003075_altered_response_to1.20436541
59MP0009840_abnormal_foam_cell1.19833517
60MP0006054_spinal_hemorrhage1.19636940
61MP0000465_gastrointestinal_hemorrhage1.19467521
62MP0004808_abnormal_hematopoietic_stem1.17253291
63MP0000858_altered_metastatic_potential1.14635010
64MP0005167_abnormal_blood-brain_barrier1.13833546
65MP0003191_abnormal_cellular_cholesterol1.08010950
66MP0003221_abnormal_cardiomyocyte_apopto1.04294869
67MP0010352_gastrointestinal_tract_polyps1.00368152
68MP0002254_reproductive_system_inflammat1.00344268
69MP0005166_decreased_susceptibility_to0.99010784
70MP0003806_abnormal_nucleotide_metabolis0.98662176
71MP0009763_increased_sensitivity_to0.96054362
72MP0009765_abnormal_xenobiotic_induced0.95294997
73MP0003453_abnormal_keratinocyte_physiol0.92814538
74MP0002332_abnormal_exercise_endurance0.92662028
75MP0010307_abnormal_tumor_latency0.92014637
76MP0005164_abnormal_response_to0.90190601
77MP0004381_abnormal_hair_follicle0.87572666
78MP0002396_abnormal_hematopoietic_system0.87412747
79MP0002277_abnormal_respiratory_mucosa0.87138826
80MP0000604_amyloidosis0.86595297
81MP0003183_abnormal_peptide_metabolism0.86147310
82MP0002139_abnormal_hepatobiliary_system0.85834860
83MP0004883_abnormal_blood_vessel0.82781278
84MP0003866_abnormal_defecation0.81298584
85MP0001851_eye_inflammation0.74634671
86MP0002132_abnormal_respiratory_system0.74182205
87MP0001873_stomach_inflammation0.73324414
88MP0010094_abnormal_chromosome_stability0.72955337
89MP0002877_abnormal_melanocyte_morpholog0.71758844
90MP0002019_abnormal_tumor_incidence0.70533539
91MP0003091_abnormal_cell_migration0.69259483
92MP0000371_diluted_coat_color0.68605471
93MP0000015_abnormal_ear_pigmentation0.67580255
94MP0003690_abnormal_glial_cell0.66941928
95MP0005647_abnormal_sex_gland0.66930372
96MP0003195_calcinosis0.63847099
97MP0002009_preneoplasia0.61645482
98MP0000490_abnormal_crypts_of0.61541721
99MP0003045_fibrosis0.61399520
100MP0000249_abnormal_blood_vessel0.58742030

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.28888641
2Optic neuritis (HP:0100653)5.06850731
3Retrobulbar optic neuritis (HP:0100654)5.06850731
4Recurrent abscess formation (HP:0002722)4.81853671
5Eczematoid dermatitis (HP:0000976)4.76279197
6Stomatitis (HP:0010280)4.74014144
7Orchitis (HP:0100796)4.69833693
8Abnormality of macrophages (HP:0004311)4.52883691
9Myositis (HP:0100614)4.34736899
10T lymphocytopenia (HP:0005403)4.32757295
11Abnormality of T cell number (HP:0011839)4.31519449
12Mediastinal lymphadenopathy (HP:0100721)4.18702103
13Recurrent viral infections (HP:0004429)3.87311344
14Recurrent fungal infections (HP:0002841)3.81399465
15Keratoconjunctivitis sicca (HP:0001097)3.78356683
16Autoimmune thrombocytopenia (HP:0001973)3.78082985
17Abnormality of glycolipid metabolism (HP:0010969)3.68843221
18Abnormality of liposaccharide metabolism (HP:0010968)3.68843221
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.68843221
20Autoimmune hemolytic anemia (HP:0001890)3.62410093
21Vasculitis (HP:0002633)3.57437132
22Recurrent gram-negative bacterial infections (HP:0005420)3.56766875
23Keratoconjunctivitis (HP:0001096)3.46112526
24Recurrent skin infections (HP:0001581)3.38375791
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.33714444
26Elevated erythrocyte sedimentation rate (HP:0003565)3.31492488
27Meningitis (HP:0001287)3.30354557
28Pulmonary infiltrates (HP:0002113)3.20989575
29Recurrent cutaneous fungal infections (HP:0011370)3.12437634
30Chronic mucocutaneous candidiasis (HP:0002728)3.12437634
31Encephalitis (HP:0002383)3.11509705
32Abnormality of T cells (HP:0002843)3.06611615
33Increased IgM level (HP:0003496)3.01516397
34IgA deficiency (HP:0002720)2.98907405
35Leukocytosis (HP:0001974)2.96725661
36Hemoptysis (HP:0002105)2.94993397
37Eosinophilia (HP:0001880)2.92589188
38Gastrointestinal infarctions (HP:0005244)2.92298139
39Arterial thrombosis (HP:0004420)2.91989281
40Gangrene (HP:0100758)2.91478906
41Disinhibition (HP:0000734)2.83565793
42Chronic obstructive pulmonary disease (HP:0006510)2.81896943
43Obstructive lung disease (HP:0006536)2.81896943
44Vacuolated lymphocytes (HP:0001922)2.72216840
45Urticaria (HP:0001025)2.70783165
46IgM deficiency (HP:0002850)2.69180913
47Spontaneous hematomas (HP:0007420)2.65811680
48Granulocytopenia (HP:0001913)2.64487995
49Abnormality of B cell number (HP:0010975)2.61872463
50Recurrent bronchitis (HP:0002837)2.59235259
51B lymphocytopenia (HP:0010976)2.54531491
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.53161708
53Abnormality of eosinophils (HP:0001879)2.51194797
54IgG deficiency (HP:0004315)2.50903699
55Gingivitis (HP:0000230)2.50722488
56Hematochezia (HP:0002573)2.46932149
57Polyneuropathy (HP:0001271)2.44919973
58Anorexia (HP:0002039)2.42410875
59Amaurosis fugax (HP:0100576)2.42363726
60Increased cerebral lipofuscin (HP:0011813)2.41445205
61Colitis (HP:0002583)2.40690211
62Chest pain (HP:0100749)2.39620071
63Lymphopenia (HP:0001888)2.37368746
64Abnormality of T cell physiology (HP:0011840)2.36672248
65Panhypogammaglobulinemia (HP:0003139)2.36503968
66Chronic diarrhea (HP:0002028)2.36396221
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.35631178
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.35086480
69Osteomyelitis (HP:0002754)2.34848515
70Loss of speech (HP:0002371)2.33135327
71Combined immunodeficiency (HP:0005387)2.27508785
72Abnormality of the prostate (HP:0008775)2.24282067
73Gastrointestinal stroma tumor (HP:0100723)2.23729834
74Abnormality of the pleura (HP:0002103)2.20498585
75Pulmonary embolism (HP:0002204)2.20092930
76Inflammation of the large intestine (HP:0002037)2.19466184
77Cellulitis (HP:0100658)2.15570080
78Agnosia (HP:0010524)2.09015059
79Fatigue (HP:0012378)2.05595563
80Acute hepatic failure (HP:0006554)2.04639719
81Viral hepatitis (HP:0006562)2.04340413
82Joint swelling (HP:0001386)2.03149053
83Myocardial infarction (HP:0001658)2.02122544
84Lymphoma (HP:0002665)2.00614181
85Recurrent sinusitis (HP:0011108)1.99461669
86Keratitis (HP:0000491)1.95875355
87Increased IgE level (HP:0003212)1.94733630
88Gastrointestinal inflammation (HP:0004386)1.94674795
89Slow saccadic eye movements (HP:0000514)1.92696905
90Prostate neoplasm (HP:0100787)1.92682453
91Gingival bleeding (HP:0000225)1.90736694
92Hypergammaglobulinemia (HP:0010702)1.90167702
93Increased neuronal autofluorescent lipopigment (HP:0002074)1.89545896
94Glomerulopathy (HP:0100820)1.88612433
95Thyroiditis (HP:0100646)1.87765085
96Neoplasm of the tracheobronchial system (HP:0100552)1.85450773
97Epistaxis (HP:0000421)1.85303177
98Pustule (HP:0200039)1.83788897
99Dysostosis multiplex (HP:0000943)1.83246617
100Abnormality of the endocardium (HP:0004306)1.82193200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.68315425
2RIPK43.65702645
3IRAK42.95211005
4MAP4K12.91817326
5BLK2.78396042
6IRAK32.74399338
7TXK2.73568157
8IKBKE2.69941603
9TYK22.55416527
10CSK2.29617689
11BMPR22.26736566
12PRPF4B2.16448826
13EIF2AK32.00120740
14IKBKB1.99793155
15TBK11.94216666
16ACVR1B1.91045343
17MATK1.89192338
18JAK31.89180422
19FGR1.85415102
20MARK31.82139867
21TAOK31.81464424
22JAK11.74440996
23MAP3K131.71692043
24IRAK11.71560755
25SYK1.58247331
26BTK1.53175151
27MAP2K31.47988434
28GRK71.47092543
29TEC1.45698179
30IRAK21.45103082
31ZAP701.41872055
32STK241.35698984
33LYN1.26987081
34JAK21.25504787
35MST41.25192865
36HCK1.17582615
37CHUK1.14548718
38TAOK21.14451864
39FES1.14225154
40PIM11.08507916
41ITK1.06899268
42MAP3K31.06057230
43KIT1.05885054
44STK101.04836162
45YES11.01993749
46MAP3K11.01958877
47BRD40.98281037
48LCK0.97281937
49FGFR30.94788046
50MAP3K50.92688220
51SIK30.89268950
52NEK90.88472273
53NLK0.88403099
54PIK3CG0.85988069
55CSF1R0.83633300
56FRK0.81789765
57TGFBR20.81444928
58TAOK10.81240333
59NME20.78726290
60CAMKK20.76508699
61MELK0.72505617
62CDK120.70639555
63CDK60.68428538
64MAP3K20.68100489
65PRKCQ0.67927131
66TRPM70.61782230
67DYRK30.61365397
68GRK60.52036385
69RAF10.47317818
70STK30.45810642
71PDK10.45186776
72MOS0.44172647
73CDC42BPA0.43905617
74CDK40.43636171
75PDK20.43394937
76EGFR0.43278467
77CLK10.42567520
78FGFR40.41606285
79KSR20.41168505
80SGK20.40020627
81EPHA30.39702069
82NEK60.37643019
83BRSK20.37001461
84MAPK110.36532474
85MKNK20.36017720
86TRIM280.35757005
87STK38L0.32301233
88MAP3K80.31826151
89STK40.30872814
90ADRBK20.30554540
91MAP3K110.28766688
92SGK30.28163282
93EIF2AK20.26860514
94EPHB10.26195980
95ALK0.25805968
96TAF10.24953189
97ABL10.24014082
98MAPKAPK20.23987290
99ERN10.23045557
100CCNB10.23032414

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.85632236
2Leishmaniasis_Homo sapiens_hsa051402.73515451
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.72563495
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.69248719
5Graft-versus-host disease_Homo sapiens_hsa053322.69241010
6Osteoclast differentiation_Homo sapiens_hsa043802.56652237
7Autoimmune thyroid disease_Homo sapiens_hsa053202.46118306
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.41522236
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.41417843
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.18754467
11Staphylococcus aureus infection_Homo sapiens_hsa051502.18605953
12Type I diabetes mellitus_Homo sapiens_hsa049402.18257308
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.16417748
14Legionellosis_Homo sapiens_hsa051342.15482024
15Measles_Homo sapiens_hsa051622.14904962
16Asthma_Homo sapiens_hsa053102.14022279
17B cell receptor signaling pathway_Homo sapiens_hsa046622.06006442
18Primary immunodeficiency_Homo sapiens_hsa053402.03093463
19Tuberculosis_Homo sapiens_hsa051522.00420493
20Rheumatoid arthritis_Homo sapiens_hsa053232.00181554
21TNF signaling pathway_Homo sapiens_hsa046681.98519894
22Influenza A_Homo sapiens_hsa051641.94507540
23Herpes simplex infection_Homo sapiens_hsa051681.81460442
24Antigen processing and presentation_Homo sapiens_hsa046121.76474860
25Malaria_Homo sapiens_hsa051441.75950441
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66967886
27Toxoplasmosis_Homo sapiens_hsa051451.66216165
28Hematopoietic cell lineage_Homo sapiens_hsa046401.65194432
29T cell receptor signaling pathway_Homo sapiens_hsa046601.62664220
30Hepatitis B_Homo sapiens_hsa051611.51421603
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.49747835
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49244871
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44821430
34Pertussis_Homo sapiens_hsa051331.36252146
35Chemokine signaling pathway_Homo sapiens_hsa040621.35804141
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33881856
37Viral myocarditis_Homo sapiens_hsa054161.32660255
38African trypanosomiasis_Homo sapiens_hsa051431.29909896
39Apoptosis_Homo sapiens_hsa042101.26715656
40Other glycan degradation_Homo sapiens_hsa005111.20089303
41Acute myeloid leukemia_Homo sapiens_hsa052211.19160200
42Hepatitis C_Homo sapiens_hsa051601.18242632
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13400250
44Phagosome_Homo sapiens_hsa041451.12242262
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11213986
46Lysosome_Homo sapiens_hsa041421.11138578
47Salmonella infection_Homo sapiens_hsa051321.09584689
48Epstein-Barr virus infection_Homo sapiens_hsa051691.07227268
49Shigellosis_Homo sapiens_hsa051310.94404512
50Dorso-ventral axis formation_Homo sapiens_hsa043200.94383146
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93114892
52Viral carcinogenesis_Homo sapiens_hsa052030.92120263
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90110881
54Prolactin signaling pathway_Homo sapiens_hsa049170.80491192
55Pancreatic cancer_Homo sapiens_hsa052120.78122688
56Systemic lupus erythematosus_Homo sapiens_hsa053220.75259686
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74280590
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71432501
59Non-small cell lung cancer_Homo sapiens_hsa052230.70133554
60Chronic myeloid leukemia_Homo sapiens_hsa052200.69172546
61HTLV-I infection_Homo sapiens_hsa051660.67001075
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65136177
63Platelet activation_Homo sapiens_hsa046110.63531013
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63403579
65FoxO signaling pathway_Homo sapiens_hsa040680.62136221
66HIF-1 signaling pathway_Homo sapiens_hsa040660.61143425
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.58747380
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.56323145
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.55905756
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55757306
71Renal cell carcinoma_Homo sapiens_hsa052110.53907537
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52112771
73Prostate cancer_Homo sapiens_hsa052150.49752694
74Type II diabetes mellitus_Homo sapiens_hsa049300.49230226
75p53 signaling pathway_Homo sapiens_hsa041150.45634658
76mTOR signaling pathway_Homo sapiens_hsa041500.45303846
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42765392
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42141247
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.40858497
80VEGF signaling pathway_Homo sapiens_hsa043700.38932666
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38408325
82Amoebiasis_Homo sapiens_hsa051460.37379052
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.35554649
84Bladder cancer_Homo sapiens_hsa052190.34903072
85Small cell lung cancer_Homo sapiens_hsa052220.32317105
86MAPK signaling pathway_Homo sapiens_hsa040100.31188729
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30778016
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30301533
89Non-homologous end-joining_Homo sapiens_hsa034500.29884653
90Sphingolipid metabolism_Homo sapiens_hsa006000.28259231
91Insulin resistance_Homo sapiens_hsa049310.26748632
92Regulation of autophagy_Homo sapiens_hsa041400.24568428
93MicroRNAs in cancer_Homo sapiens_hsa052060.23444920
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23139684
95Endometrial cancer_Homo sapiens_hsa052130.22289384
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21866181
97Cell cycle_Homo sapiens_hsa041100.18533717
98Basal transcription factors_Homo sapiens_hsa030220.18220510
99RNA degradation_Homo sapiens_hsa030180.17783615
100Endocytosis_Homo sapiens_hsa041440.16791176

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