ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.95085293
2	neuron remodeling (GO:0016322)	4.62134124
3	regulation of DNA endoreduplication (GO:0032875)	4.42445806
4	gamma-aminobutyric acid transport (GO:0015812)	4.13405901
5	cell proliferation in forebrain (GO:0021846)	4.13250893
6	sulfation (GO:0051923)	3.81584269
7	water-soluble vitamin biosynthetic process (GO:0042364)	3.65124870
8	snRNA transcription (GO:0009301)	3.57916894
9	head development (GO:0060322)	3.53249172
10	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.52971378
11	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.52628758
12	transmission of nerve impulse (GO:0019226)	3.47143988
13	negative regulation of T cell differentiation in thymus (GO:0033085)	3.43136233
14	regulation of posttranscriptional gene silencing (GO:0060147)	3.41712363
15	regulation of gene silencing by miRNA (GO:0060964)	3.41712363
16	regulation of gene silencing by RNA (GO:0060966)	3.41712363
17	pyrimidine nucleobase catabolic process (GO:0006208)	3.40855530
18	indolalkylamine metabolic process (GO:0006586)	3.32886474
19	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.32551366
20	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.25764916
21	presynaptic membrane assembly (GO:0097105)	3.21876852
22	cellular response to ATP (GO:0071318)	3.15445502
23	somite development (GO:0061053)	3.15298028
24	neuron maturation (GO:0042551)	3.11648014
25	L-fucose catabolic process (GO:0042355)	3.11441494
26	fucose catabolic process (GO:0019317)	3.11441494
27	L-fucose metabolic process (GO:0042354)	3.11441494
28	cell differentiation in hindbrain (GO:0021533)	3.10197975
29	detection of light stimulus involved in sensory perception (GO:0050962)	3.08768257
30	detection of light stimulus involved in visual perception (GO:0050908)	3.08768257
31	indole-containing compound catabolic process (GO:0042436)	3.08562209
32	indolalkylamine catabolic process (GO:0046218)	3.08562209
33	tryptophan catabolic process (GO:0006569)	3.08562209
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.08114983
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.08114983
36	response to pheromone (GO:0019236)	3.06391888
37	protein polyglutamylation (GO:0018095)	3.05323249
38	reflex (GO:0060004)	3.02138816
39	cerebellar Purkinje cell differentiation (GO:0021702)	2.97501260
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.97401746
41	serotonin metabolic process (GO:0042428)	2.97034391
42	presynaptic membrane organization (GO:0097090)	2.94765762
43	kidney morphogenesis (GO:0060993)	2.94631381
44	epithelial cilium movement (GO:0003351)	2.92549840
45	interkinetic nuclear migration (GO:0022027)	2.90023018
46	behavioral response to ethanol (GO:0048149)	2.89290587
47	cellular ketone body metabolic process (GO:0046950)	2.88795415
48	kynurenine metabolic process (GO:0070189)	2.88786604
49	histone H2A ubiquitination (GO:0033522)	2.88669521
50	nonmotile primary cilium assembly (GO:0035058)	2.87047429
51	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.86926848
52	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.86926848
53	regulation of translation, ncRNA-mediated (GO:0045974)	2.86926848
54	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.83958024
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.80744132
56	parturition (GO:0007567)	2.80559768
57	retinal ganglion cell axon guidance (GO:0031290)	2.79972439
58	primary amino compound metabolic process (GO:1901160)	2.79251552
59	neuronal action potential (GO:0019228)	2.75706912
60	indole-containing compound metabolic process (GO:0042430)	2.75269156
61	neuronal action potential propagation (GO:0019227)	2.73828505
62	negative regulation of systemic arterial blood pressure (GO:0003085)	2.72792899
63	endoderm formation (GO:0001706)	2.71862180
64	regulation of hippo signaling (GO:0035330)	2.71063424
65	nucleobase catabolic process (GO:0046113)	2.70743627
66	cerebellar granule cell differentiation (GO:0021707)	2.70673558
67	negative regulation of mast cell activation (GO:0033004)	2.70580626
68	regulation of action potential (GO:0098900)	2.66591732
69	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.65611373
70	replication fork processing (GO:0031297)	2.64350193
71	peristalsis (GO:0030432)	2.63856677
72	positive regulation of synapse assembly (GO:0051965)	2.63092680
73	forebrain neuron differentiation (GO:0021879)	2.62428983
74	membrane depolarization during action potential (GO:0086010)	2.61987711
75	positive regulation of T cell apoptotic process (GO:0070234)	2.61560926
76	neurotransmitter-gated ion channel clustering (GO:0072578)	2.60928938
77	spinal cord motor neuron differentiation (GO:0021522)	2.60103413
78	oocyte development (GO:0048599)	2.60036272
79	regulation of neurotransmitter uptake (GO:0051580)	2.59337365
80	ketone body metabolic process (GO:1902224)	2.57640657
81	regulation of telomere maintenance (GO:0032204)	2.56974462
82	tryptophan metabolic process (GO:0006568)	2.55176262
83	platelet dense granule organization (GO:0060155)	2.54256079
84	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.53772250
85	NADH dehydrogenase complex assembly (GO:0010257)	2.53772250
86	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.53772250
87	cilium morphogenesis (GO:0060271)	2.53363259
88	protein complex biogenesis (GO:0070271)	2.52392194
89	dendritic spine morphogenesis (GO:0060997)	2.52148078
90	regulation of collateral sprouting (GO:0048670)	2.48756955
91	DNA deamination (GO:0045006)	2.47554741
92	rRNA catabolic process (GO:0016075)	2.47185641
93	cell differentiation in spinal cord (GO:0021515)	2.47141241
94	photoreceptor cell development (GO:0042461)	2.47032109
95	otic vesicle formation (GO:0030916)	2.46860155
96	protein localization to cilium (GO:0061512)	2.44061048
97	axoneme assembly (GO:0035082)	2.43132648
98	cilium organization (GO:0044782)	2.42187233
99	postsynaptic membrane organization (GO:0001941)	2.41155250
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.40454901

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.22445567
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.74291067
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.25419040
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.75623354
5	VDR_22108803_ChIP-Seq_LS180_Human	2.66130663
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.63436391
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58508480
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47733970
9	EWS_26573619_Chip-Seq_HEK293_Human	2.37564228
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.31857186
11	FUS_26573619_Chip-Seq_HEK293_Human	2.31186524
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.27721954
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26702389
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25000567
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.19656062
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.18452982
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.13402768
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04468319
19	P300_19829295_ChIP-Seq_ESCs_Human	2.03058460
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.99390490
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.95913881
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.88705585
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.84357260
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.75044876
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68745304
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.67521483
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62368572
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61034074
29	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60536015
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59218788
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55754513
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55701599
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55530094
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55315469
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.54968320
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54788240
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54585037
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52859725
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.52458188
40	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50747096
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.49455036
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49045780
43	STAT3_23295773_ChIP-Seq_U87_Human	1.48954059
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47984514
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.45428665
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45428665
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43967971
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42717584
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41662761
50	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.40496244
51	AR_25329375_ChIP-Seq_VCAP_Human	1.39961112
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39789147
53	TCF4_23295773_ChIP-Seq_U87_Human	1.39005206
54	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.38628926
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36223550
56	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32479267
57	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.32060236
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.31867980
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.31319684
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30978701
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30978701
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30384736
63	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29709320
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28450629
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.27155511
66	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25272909
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.24963563
68	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21107721
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.20320893
70	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.20160769
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17874515
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15960357
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15960357
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15282977
75	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13441479
76	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12952595
77	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.11801432
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.09969986
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08499242
80	JUN_21703547_ChIP-Seq_K562_Human	1.06289331
81	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.05623654
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.05464602
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05415573
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05126187
85	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.05010928
86	KDM2B_26808549_Chip-Seq_REH_Human	1.04816542
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04680230
88	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04680230
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04522744
90	NCOR_22424771_ChIP-Seq_293T_Human	1.04392936
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03842297
92	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03775706
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.01167057
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00465737
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98959848
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98574446
97	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98553403
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98307899
99	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98300592
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98250576

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.26371001
2	MP0002102_abnormal_ear_morphology	3.21272505
3	MP0002837_dystrophic_cardiac_calcinosis	3.11875422
4	MP0003646_muscle_fatigue	2.95872118
5	MP0006292_abnormal_olfactory_placode	2.81216786
6	MP0008877_abnormal_DNA_methylation	2.59970879
7	MP0003787_abnormal_imprinting	2.33073129
8	MP0004885_abnormal_endolymph	2.20176406
9	MP0002160_abnormal_reproductive_system	2.15198216
10	MP0005551_abnormal_eye_electrophysiolog	2.12985276
11	MP0003890_abnormal_embryonic-extraembry	2.02096203
12	MP0001485_abnormal_pinna_reflex	2.01470514
13	MP0005423_abnormal_somatic_nervous	1.99896050
14	MP0000778_abnormal_nervous_system	1.93674735
15	MP0003195_calcinosis	1.86267140
16	MP0003136_yellow_coat_color	1.83102680
17	MP0004145_abnormal_muscle_electrophysio	1.80455694
18	MP0000049_abnormal_middle_ear	1.76401989
19	MP0001968_abnormal_touch/_nociception	1.70783871
20	MP0002272_abnormal_nervous_system	1.64922259
21	MP0005646_abnormal_pituitary_gland	1.61465442
22	MP0000631_abnormal_neuroendocrine_gland	1.59960502
23	MP0004133_heterotaxia	1.57063316
24	MP0005389_reproductive_system_phenotype	1.54618150
25	MP0009745_abnormal_behavioral_response	1.48593659
26	MP0004130_abnormal_muscle_cell	1.48592090
27	MP0009046_muscle_twitch	1.46688902
28	MP0006276_abnormal_autonomic_nervous	1.45763754
29	MP0001529_abnormal_vocalization	1.45379465
30	MP0006072_abnormal_retinal_apoptosis	1.44695163
31	MP0002876_abnormal_thyroid_physiology	1.43607893
32	MP0004142_abnormal_muscle_tone	1.41543289
33	MP0002928_abnormal_bile_duct	1.41083738
34	MP0003635_abnormal_synaptic_transmissio	1.40700799
35	MP0005253_abnormal_eye_physiology	1.37189648
36	MP0003937_abnormal_limbs/digits/tail_de	1.36284106
37	MP0001486_abnormal_startle_reflex	1.35596966
38	MP0001293_anophthalmia	1.33634000
39	MP0008789_abnormal_olfactory_epithelium	1.33323265
40	MP0002572_abnormal_emotion/affect_behav	1.33259766
41	MP0003119_abnormal_digestive_system	1.32850155
42	MP0000427_abnormal_hair_cycle	1.30802220
43	MP0002638_abnormal_pupillary_reflex	1.28561801
44	MP0008872_abnormal_physiological_respon	1.27334246
45	MP0002736_abnormal_nociception_after	1.26859681
46	MP0003011_delayed_dark_adaptation	1.26029781
47	MP0002184_abnormal_innervation	1.25865960
48	MP0002733_abnormal_thermal_nociception	1.25355471
49	MP0002734_abnormal_mechanical_nocicepti	1.25250708
50	MP0001986_abnormal_taste_sensitivity	1.23501905
51	MP0003121_genomic_imprinting	1.23491377
52	MP0002063_abnormal_learning/memory/cond	1.23489037
53	MP0000372_irregular_coat_pigmentation	1.23231353
54	MP0002557_abnormal_social/conspecific_i	1.23082682
55	MP0005084_abnormal_gallbladder_morpholo	1.21464533
56	MP0002938_white_spotting	1.20071756
57	MP0008775_abnormal_heart_ventricle	1.15775582
58	MP0001984_abnormal_olfaction	1.15538288
59	MP0002735_abnormal_chemical_nociception	1.14769955
60	MP0001970_abnormal_pain_threshold	1.13691015
61	MP0002752_abnormal_somatic_nervous	1.13423433
62	MP0005195_abnormal_posterior_eye	1.13274955
63	MP0002751_abnormal_autonomic_nervous	1.12281891
64	MP0000026_abnormal_inner_ear	1.10484535
65	MP0008875_abnormal_xenobiotic_pharmacok	1.10401589
66	MP0000955_abnormal_spinal_cord	1.09227316
67	MP0002064_seizures	1.08589592
68	MP0002653_abnormal_ependyma_morphology	1.04265673
69	MP0005367_renal/urinary_system_phenotyp	1.03854464
70	MP0000516_abnormal_urinary_system	1.03854464
71	MP0002234_abnormal_pharynx_morphology	1.03170237
72	MP0004215_abnormal_myocardial_fiber	1.02926651
73	MP0002882_abnormal_neuron_morphology	1.00180117
74	MP0005394_taste/olfaction_phenotype	0.97983045
75	MP0005499_abnormal_olfactory_system	0.97983045
76	MP0000569_abnormal_digit_pigmentation	0.95488542
77	MP0003938_abnormal_ear_development	0.95368148
78	MP0004134_abnormal_chest_morphology	0.92485835
79	MP0001188_hyperpigmentation	0.91880586
80	MP0005647_abnormal_sex_gland	0.91706015
81	MP0003567_abnormal_fetal_cardiomyocyte	0.90988474
82	MP0004270_analgesia	0.90927814
83	MP0001905_abnormal_dopamine_level	0.87083033
84	MP0009250_abnormal_appendicular_skeleto	0.86721860
85	MP0004924_abnormal_behavior	0.85883169
86	MP0005386_behavior/neurological_phenoty	0.85883169
87	MP0001963_abnormal_hearing_physiology	0.85730702
88	MP0003718_maternal_effect	0.85487013
89	MP0002067_abnormal_sensory_capabilities	0.83807731
90	MP0002229_neurodegeneration	0.83654792
91	MP0005187_abnormal_penis_morphology	0.83296593
92	MP0005167_abnormal_blood-brain_barrier	0.82871080
93	MP0003137_abnormal_impulse_conducting	0.82620108
94	MP0002163_abnormal_gland_morphology	0.82315162
95	MP0003861_abnormal_nervous_system	0.82187897
96	MP0002210_abnormal_sex_determination	0.82075459
97	MP0003122_maternal_imprinting	0.81779092
98	MP0000230_abnormal_systemic_arterial	0.80298828
99	MP0002152_abnormal_brain_morphology	0.79535222
100	MP0001286_abnormal_eye_development	0.79466497

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.23151949
2	Pancreatic cysts (HP:0001737)	4.21020334
3	True hermaphroditism (HP:0010459)	4.12245269
4	Nephronophthisis (HP:0000090)	3.79236945
5	Medial flaring of the eyebrow (HP:0010747)	3.49297291
6	Congenital stationary night blindness (HP:0007642)	3.37715331
7	Abnormality of midbrain morphology (HP:0002418)	3.26769671
8	Molar tooth sign on MRI (HP:0002419)	3.26769671
9	Gait imbalance (HP:0002141)	3.24337629
10	Congenital primary aphakia (HP:0007707)	3.18045377
11	Nephrogenic diabetes insipidus (HP:0009806)	3.14455359
12	Genetic anticipation (HP:0003743)	3.12457286
13	Abnormality of the renal medulla (HP:0100957)	3.09833104
14	Pendular nystagmus (HP:0012043)	3.09385746
15	Hyperventilation (HP:0002883)	2.98571759
16	Progressive cerebellar ataxia (HP:0002073)	2.86850068
17	Cystic liver disease (HP:0006706)	2.86776606
18	Tubular atrophy (HP:0000092)	2.86497945
19	Abolished electroretinogram (ERG) (HP:0000550)	2.78623906
20	Chronic hepatic failure (HP:0100626)	2.75755315
21	Genital tract atresia (HP:0001827)	2.71792907
22	Vaginal atresia (HP:0000148)	2.71509979
23	Poor coordination (HP:0002370)	2.61748227
24	Type II lissencephaly (HP:0007260)	2.61636583
25	Chorioretinal atrophy (HP:0000533)	2.52683757
26	Sclerocornea (HP:0000647)	2.52098129
27	Gaze-evoked nystagmus (HP:0000640)	2.48447401
28	Decreased central vision (HP:0007663)	2.47995407
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.37006201
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36705776
31	Increased corneal curvature (HP:0100692)	2.36598359
32	Keratoconus (HP:0000563)	2.36598359
33	Attenuation of retinal blood vessels (HP:0007843)	2.35229822
34	Methylmalonic acidemia (HP:0002912)	2.33827080
35	Abnormality of the renal cortex (HP:0011035)	2.33270406
36	Lissencephaly (HP:0001339)	2.33204371
37	Fibular aplasia (HP:0002990)	2.31765535
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31322799
39	Furrowed tongue (HP:0000221)	2.30727731
40	Male pseudohermaphroditism (HP:0000037)	2.29934963
41	Anencephaly (HP:0002323)	2.27264167
42	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.25904995
43	Abnormality of alanine metabolism (HP:0010916)	2.25904995
44	Hyperalaninemia (HP:0003348)	2.25904995
45	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.25532910
46	3-Methylglutaconic aciduria (HP:0003535)	2.22375945
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.19497079
48	Hyperglycinemia (HP:0002154)	2.15990819
49	Protruding tongue (HP:0010808)	2.15521514
50	Postaxial foot polydactyly (HP:0001830)	2.14936999
51	Specific learning disability (HP:0001328)	2.11825432
52	Hypothermia (HP:0002045)	2.11138579
53	Inability to walk (HP:0002540)	2.06805095
54	Abnormality of the renal collecting system (HP:0004742)	2.06405871
55	Postaxial hand polydactyly (HP:0001162)	2.03664341
56	Congenital hepatic fibrosis (HP:0002612)	2.03122785
57	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.99455526
58	Agitation (HP:0000713)	1.98113837
59	Progressive inability to walk (HP:0002505)	1.96945928
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.95772832
61	Bony spicule pigmentary retinopathy (HP:0007737)	1.94995283
62	Hemiparesis (HP:0001269)	1.93733204
63	Colon cancer (HP:0003003)	1.91139808
64	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.91080149
65	Asplenia (HP:0001746)	1.90420351
66	Septo-optic dysplasia (HP:0100842)	1.89605269
67	Short foot (HP:0001773)	1.88744281
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88467840
69	Abnormality of DNA repair (HP:0003254)	1.87236013
70	Optic nerve hypoplasia (HP:0000609)	1.86442456
71	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85804668
72	Congenital, generalized hypertrichosis (HP:0004540)	1.85506197
73	Decreased circulating renin level (HP:0003351)	1.85370651
74	Oligohydramnios (HP:0001562)	1.85164410
75	Short hallux (HP:0010109)	1.84512778
76	Broad-based gait (HP:0002136)	1.83174862
77	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.82837348
78	Renal cortical cysts (HP:0000803)	1.81171405
79	Drooling (HP:0002307)	1.81135002
80	Confusion (HP:0001289)	1.79754231
81	Occipital encephalocele (HP:0002085)	1.79530941
82	Tachypnea (HP:0002789)	1.78731039
83	Chromsome breakage (HP:0040012)	1.77970949
84	Aplasia/Hypoplasia of the patella (HP:0006498)	1.77471846
85	Small hand (HP:0200055)	1.77351907
86	Short tibia (HP:0005736)	1.75149807
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73830210
88	Hyperglycinuria (HP:0003108)	1.73527503
89	Preaxial hand polydactyly (HP:0001177)	1.72268402
90	Abnormal biliary tract physiology (HP:0012439)	1.72067075
91	Bile duct proliferation (HP:0001408)	1.72067075
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.71013029
93	Absent/shortened dynein arms (HP:0200106)	1.71013029
94	Abnormality of the middle phalanges of the toes (HP:0010183)	1.70827983
95	Partial agenesis of the corpus callosum (HP:0001338)	1.70555804
96	Methylmalonic aciduria (HP:0012120)	1.70416599
97	Patellar aplasia (HP:0006443)	1.70271270
98	Retinitis pigmentosa (HP:0000510)	1.69859152
99	Dandy-Walker malformation (HP:0001305)	1.68967568
100	Absent thumb (HP:0009777)	1.68616424

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.38290286
2	MAP3K4	4.09574877
3	CASK	2.97946679
4	GRK1	2.81676343
5	BMPR1B	2.78406768
6	WNK3	2.74212361
7	ZAK	2.55057925
8	ADRBK2	2.53440689
9	ACVR1B	2.27623255
10	WNK4	2.22687625
11	MAPK13	2.05887818
12	NUAK1	1.91314977
13	TLK1	1.71222901
14	PINK1	1.63270119
15	TAOK3	1.53698037
16	DYRK2	1.44567475
17	INSRR	1.43824450
18	MAP2K7	1.42851738
19	MAP4K2	1.41427024
20	TNIK	1.39603416
21	STK39	1.34064609
22	MARK1	1.32482154
23	TAF1	1.25067861
24	TIE1	1.17547114
25	MKNK2	1.16979520
26	CAMKK2	1.07484219
27	TRIM28	1.07121181
28	PNCK	1.06372645
29	NTRK2	1.06266147
30	MAPKAPK5	1.05718326
31	VRK1	1.04781334
32	STK38L	1.03510538
33	BCR	1.02932860
34	CSNK1G2	1.02622687
35	CSNK1G1	1.00316054
36	OXSR1	1.00246252
37	ERBB3	0.96094779
38	CSNK1G3	0.94777351
39	EPHB2	0.93602244
40	TGFBR1	0.91436985
41	PAK3	0.91071121
42	CSNK1A1L	0.88461668
43	NTRK3	0.85388390
44	PRKCG	0.85256087
45	ADRBK1	0.83852379
46	PRKCE	0.82193706
47	TYRO3	0.81994723
48	EPHA4	0.79486830
49	VRK2	0.77463407
50	MAP2K4	0.76916675
51	AKT3	0.74159892
52	CDC7	0.73948091
53	PLK3	0.72611524
54	FGFR2	0.71828622
55	PLK2	0.71417121
56	MAPK15	0.70795855
57	RPS6KA5	0.69675502
58	DAPK2	0.68192722
59	PLK4	0.67422624
60	SGK2	0.65249303
61	DYRK1A	0.61718084
62	PLK1	0.61240389
63	STK11	0.60170865
64	CAMK1D	0.59149192
65	CAMK1G	0.59031049
66	PRKD2	0.58950369
67	TEC	0.58721806
68	ERBB2	0.58472287
69	MKNK1	0.57977278
70	ATR	0.57697651
71	TXK	0.57239911
72	PKN1	0.56672332
73	BRSK2	0.55348261
74	BCKDK	0.52796249
75	PRKACA	0.52294868
76	PIK3CA	0.49035307
77	PRKCZ	0.48515296
78	CSNK1D	0.48026009
79	CSNK1A1	0.47154553
80	OBSCN	0.46227936
81	CAMK2A	0.45769783
82	RPS6KA6	0.45271265
83	WNK1	0.43805431
84	NEK2	0.41928967
85	FES	0.41912735
86	SGK223	0.41847470
87	SGK494	0.41847470
88	CHEK2	0.41108343
89	WEE1	0.40192262
90	CDK3	0.39739939
91	ATM	0.38811535
92	STK3	0.38648526
93	CDK5	0.36600420
94	PASK	0.34999045
95	MAPKAPK3	0.34715498
96	DYRK3	0.34141780
97	CAMK1	0.34057757
98	AURKA	0.33115342
99	FLT3	0.32782562
100	CHUK	0.32743177

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.07788855
2	Nicotine addiction_Homo sapiens_hsa05033	2.57360051
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42504599
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24720352
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.08141204
6	Butanoate metabolism_Homo sapiens_hsa00650	2.07420304
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.01665807
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.97936110
9	Linoleic acid metabolism_Homo sapiens_hsa00591	1.94617516
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.94005443
11	Protein export_Homo sapiens_hsa03060	1.88503557
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87812306
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.86093160
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84089476
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.81330703
16	Homologous recombination_Homo sapiens_hsa03440	1.79151800
17	Basal transcription factors_Homo sapiens_hsa03022	1.78587557
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.69206659
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66290763
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61100303
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.55678667
22	Morphine addiction_Homo sapiens_hsa05032	1.50239207
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45231613
24	Sulfur relay system_Homo sapiens_hsa04122	1.45135175
25	Caffeine metabolism_Homo sapiens_hsa00232	1.39254628
26	Taste transduction_Homo sapiens_hsa04742	1.38047524
27	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.36980011
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36940384
29	Olfactory transduction_Homo sapiens_hsa04740	1.36288617
30	Cocaine addiction_Homo sapiens_hsa05030	1.31473753
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.30759474
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.29437583
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.24548106
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.24547822
35	Retinol metabolism_Homo sapiens_hsa00830	1.24228585
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23008727
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.22771711
38	Peroxisome_Homo sapiens_hsa04146	1.21545879
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.21353124
40	RNA polymerase_Homo sapiens_hsa03020	1.20477060
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19864785
42	Axon guidance_Homo sapiens_hsa04360	1.17473851
43	RNA degradation_Homo sapiens_hsa03018	1.14915328
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.12293790
45	Steroid biosynthesis_Homo sapiens_hsa00100	1.12265381
46	Glycerolipid metabolism_Homo sapiens_hsa00561	1.10345327
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.09762426
48	Propanoate metabolism_Homo sapiens_hsa00640	1.09559543
49	Circadian entrainment_Homo sapiens_hsa04713	1.08157496
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.07390056
51	Dopaminergic synapse_Homo sapiens_hsa04728	1.06777302
52	GABAergic synapse_Homo sapiens_hsa04727	1.06639578
53	Serotonergic synapse_Homo sapiens_hsa04726	1.04035331
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00902158
55	Parkinsons disease_Homo sapiens_hsa05012	0.91412259
56	Sulfur metabolism_Homo sapiens_hsa00920	0.91391767
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91174920
58	Insulin secretion_Homo sapiens_hsa04911	0.87465964
59	Histidine metabolism_Homo sapiens_hsa00340	0.87231808
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.87197619
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.86779551
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.84976742
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.84546018
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82348838
65	Huntingtons disease_Homo sapiens_hsa05016	0.79574126
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79265555
67	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78404288
68	Regulation of autophagy_Homo sapiens_hsa04140	0.77683132
69	Tyrosine metabolism_Homo sapiens_hsa00350	0.76350055
70	ABC transporters_Homo sapiens_hsa02010	0.75866941
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.74336125
72	Amphetamine addiction_Homo sapiens_hsa05031	0.73233066
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.72660503
74	RNA transport_Homo sapiens_hsa03013	0.70953416
75	Basal cell carcinoma_Homo sapiens_hsa05217	0.68621373
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.63336350
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56853919
78	One carbon pool by folate_Homo sapiens_hsa00670	0.55947711
79	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.55091875
80	Cholinergic synapse_Homo sapiens_hsa04725	0.55011213
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.54200424
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53834130
83	Melanoma_Homo sapiens_hsa05218	0.52331875
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52040190
85	Alzheimers disease_Homo sapiens_hsa05010	0.51687336
86	Purine metabolism_Homo sapiens_hsa00230	0.51075652
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49789099
88	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.49693450
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49276300
90	Renin secretion_Homo sapiens_hsa04924	0.48990616
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48558513
92	Metabolic pathways_Homo sapiens_hsa01100	0.47927075
93	p53 signaling pathway_Homo sapiens_hsa04115	0.47333151
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46326365
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.45338017
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45326857
97	Fatty acid degradation_Homo sapiens_hsa00071	0.44988965
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44192631
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.43537184
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43476856

ZNF268

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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