ZNF273

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.03002700
2cilium or flagellum-dependent cell motility (GO:0001539)5.78735001
3axonemal dynein complex assembly (GO:0070286)5.66565835
4epithelial cilium movement (GO:0003351)5.42195655
5cilium movement (GO:0003341)5.38546420
6behavioral response to nicotine (GO:0035095)4.57575341
7axoneme assembly (GO:0035082)4.37345635
8regulation of cilium movement (GO:0003352)4.07073156
9centriole replication (GO:0007099)3.74194486
10motile cilium assembly (GO:0044458)3.73022296
11fucose catabolic process (GO:0019317)3.70702609
12L-fucose metabolic process (GO:0042354)3.70702609
13L-fucose catabolic process (GO:0042355)3.70702609
14cilium organization (GO:0044782)3.56660458
15response to pheromone (GO:0019236)3.54886067
16nonmotile primary cilium assembly (GO:0035058)3.44614459
17cilium assembly (GO:0042384)3.44460188
18cilium morphogenesis (GO:0060271)3.43218897
19intraciliary transport (GO:0042073)3.38731101
20neural tube formation (GO:0001841)3.32138847
21retinal cone cell development (GO:0046549)3.27645820
22protein localization to cilium (GO:0061512)3.20481783
23replication fork processing (GO:0031297)3.18291374
24protein polyglutamylation (GO:0018095)3.16962533
25left/right axis specification (GO:0070986)3.16414674
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.09987565
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08947659
28microtubule depolymerization (GO:0007019)3.06607802
29DNA double-strand break processing (GO:0000729)3.03739821
30reciprocal DNA recombination (GO:0035825)2.97969839
31reciprocal meiotic recombination (GO:0007131)2.97969839
32regulation of nuclear cell cycle DNA replication (GO:0033262)2.94384294
33centriole assembly (GO:0098534)2.93423268
34rRNA catabolic process (GO:0016075)2.87384902
35cornea development in camera-type eye (GO:0061303)2.84277444
36negative regulation of telomere maintenance (GO:0032205)2.81334047
37regulation of microtubule-based movement (GO:0060632)2.81262810
38tryptophan catabolic process (GO:0006569)2.80070863
39indole-containing compound catabolic process (GO:0042436)2.80070863
40indolalkylamine catabolic process (GO:0046218)2.80070863
41photoreceptor cell maintenance (GO:0045494)2.78001764
42regulation of mitotic spindle checkpoint (GO:1903504)2.75400904
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75400904
44kynurenine metabolic process (GO:0070189)2.74640103
45piRNA metabolic process (GO:0034587)2.72271759
46recombinational repair (GO:0000725)2.71167618
47synapsis (GO:0007129)2.70624384
48regulation of meiosis I (GO:0060631)2.70067245
49negative regulation of translation, ncRNA-mediated (GO:0040033)2.67790165
50regulation of translation, ncRNA-mediated (GO:0045974)2.67790165
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67790165
52negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67210266
53double-strand break repair via homologous recombination (GO:0000724)2.67106976
54platelet dense granule organization (GO:0060155)2.66707528
55left/right pattern formation (GO:0060972)2.66318338
56indolalkylamine metabolic process (GO:0006586)2.65198607
57microtubule polymerization or depolymerization (GO:0031109)2.65100436
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64876787
59gamma-aminobutyric acid transport (GO:0015812)2.64700353
60cellular component assembly involved in morphogenesis (GO:0010927)2.63479278
61pyrimidine nucleobase catabolic process (GO:0006208)2.62249611
62spinal cord motor neuron differentiation (GO:0021522)2.59790518
63DNA deamination (GO:0045006)2.59402196
64mitochondrial respiratory chain complex I assembly (GO:0032981)2.59266527
65NADH dehydrogenase complex assembly (GO:0010257)2.59266527
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59266527
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57684501
68somatic hypermutation of immunoglobulin genes (GO:0016446)2.57408708
69somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57408708
70water-soluble vitamin biosynthetic process (GO:0042364)2.56866533
71tryptophan metabolic process (GO:0006568)2.53787893
72ubiquinone biosynthetic process (GO:0006744)2.53236830
73smoothened signaling pathway (GO:0007224)2.53148588
74atrial cardiac muscle cell action potential (GO:0086014)2.52951613
75negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52837343
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52598994
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51961002
78ubiquinone metabolic process (GO:0006743)2.50592049
79protein complex biogenesis (GO:0070271)2.50583801
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49721403
81sperm motility (GO:0030317)2.49629219
82preassembly of GPI anchor in ER membrane (GO:0016254)2.48813968
83photoreceptor cell development (GO:0042461)2.48778497
84sulfation (GO:0051923)2.47718924
85presynaptic membrane assembly (GO:0097105)2.47149128
86male meiosis I (GO:0007141)2.46431371
87kidney morphogenesis (GO:0060993)2.46382286
88protein-cofactor linkage (GO:0018065)2.45910850
89somite development (GO:0061053)2.45746008
90regulation of mesoderm development (GO:2000380)2.44899746
91respiratory chain complex IV assembly (GO:0008535)2.43184172
92microtubule bundle formation (GO:0001578)2.42620895
93determination of left/right symmetry (GO:0007368)2.42246359
94chromatin remodeling at centromere (GO:0031055)2.41837555
95protein K11-linked deubiquitination (GO:0035871)2.41682093
96detection of light stimulus involved in sensory perception (GO:0050962)2.41647919
97detection of light stimulus involved in visual perception (GO:0050908)2.41647919
98protein K6-linked ubiquitination (GO:0085020)2.39991833
99protein prenylation (GO:0018342)2.39631202
100prenylation (GO:0097354)2.39631202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.66763629
2VDR_22108803_ChIP-Seq_LS180_Human3.13551560
3GBX2_23144817_ChIP-Seq_PC3_Human2.76916034
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75589937
5IGF1R_20145208_ChIP-Seq_DFB_Human2.62598466
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55057403
7FUS_26573619_Chip-Seq_HEK293_Human2.51999658
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49930092
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46148031
10EWS_26573619_Chip-Seq_HEK293_Human2.44944253
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43952381
12EZH2_22144423_ChIP-Seq_EOC_Human2.43539588
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.35115862
14TAF15_26573619_Chip-Seq_HEK293_Human2.32226353
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28546318
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.18268529
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13599235
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10536011
19P300_19829295_ChIP-Seq_ESCs_Human2.07441780
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99715938
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95788216
22ER_23166858_ChIP-Seq_MCF-7_Human1.86448284
23IRF1_19129219_ChIP-ChIP_H3396_Human1.75071639
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74133908
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72752028
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72332773
27MYC_18940864_ChIP-ChIP_HL60_Human1.61435320
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60083820
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.58374071
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57464249
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.55614133
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54395907
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50385732
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49349592
35STAT3_23295773_ChIP-Seq_U87_Human1.49015509
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48234066
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48234066
38CBP_20019798_ChIP-Seq_JUKART_Human1.47030882
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47030882
40SMAD4_21799915_ChIP-Seq_A2780_Human1.45195217
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.44763992
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44659592
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44294593
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.42045050
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40743833
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39964447
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39814248
48RNF2_27304074_Chip-Seq_NSC_Mouse1.38408407
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37779901
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.37759568
51AR_25329375_ChIP-Seq_VCAP_Human1.37167083
52TCF4_23295773_ChIP-Seq_U87_Human1.36084862
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34352952
54TP53_22573176_ChIP-Seq_HFKS_Human1.33495681
55NANOG_19829295_ChIP-Seq_ESCs_Human1.33210297
56SOX2_19829295_ChIP-Seq_ESCs_Human1.33210297
57AR_21572438_ChIP-Seq_LNCaP_Human1.32751626
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.32223720
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32223720
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31443796
61BCAT_22108803_ChIP-Seq_LS180_Human1.30063503
62ELK1_19687146_ChIP-ChIP_HELA_Human1.29547030
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29014329
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28083978
65TCF4_22108803_ChIP-Seq_LS180_Human1.27897084
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.27004841
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26819902
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24347884
69REST_21632747_ChIP-Seq_MESCs_Mouse1.23930820
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.23550718
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23087468
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22631728
73RUNX2_22187159_ChIP-Seq_PCA_Human1.22146858
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21789880
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.19076544
76VDR_23849224_ChIP-Seq_CD4+_Human1.15818481
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15323891
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12067706
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11553217
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.10166217
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09433923
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.09219464
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.08596469
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.07779223
85NCOR_22424771_ChIP-Seq_293T_Human1.06598400
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.05793948
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05793248
88HOXB7_26014856_ChIP-Seq_BT474_Human1.04393645
89AR_20517297_ChIP-Seq_VCAP_Human1.04347209
90P53_22387025_ChIP-Seq_ESCs_Mouse1.02918714
91ETV1_20927104_ChIP-Seq_GIST48_Human0.99311327
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98265183
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97481419
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96547924
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.95631352
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95182256
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95017908
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.94946539
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94594660
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94559970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.94944361
2MP0002653_abnormal_ependyma_morphology2.73902663
3MP0003136_yellow_coat_color2.52732147
4MP0006292_abnormal_olfactory_placode2.49081622
5MP0005551_abnormal_eye_electrophysiolog2.17159882
6MP0004147_increased_porphyrin_level2.13132745
7MP0001984_abnormal_olfaction2.06728453
8MP0006072_abnormal_retinal_apoptosis2.06446195
9MP0009046_muscle_twitch2.01760286
10MP0002102_abnormal_ear_morphology2.01490339
11MP0003880_abnormal_central_pattern1.95286377
12MP0002638_abnormal_pupillary_reflex1.92585196
13MP0004133_heterotaxia1.91010815
14MP0001968_abnormal_touch/_nociception1.89919065
15MP0003787_abnormal_imprinting1.85239720
16MP0005253_abnormal_eye_physiology1.81812623
17MP0004043_abnormal_pH_regulation1.80670209
18MP0001485_abnormal_pinna_reflex1.75123709
19MP0009745_abnormal_behavioral_response1.72867568
20MP0008789_abnormal_olfactory_epithelium1.72565671
21MP0004142_abnormal_muscle_tone1.69978212
22MP0002736_abnormal_nociception_after1.68635753
23MP0008875_abnormal_xenobiotic_pharmacok1.68139689
24MP0000631_abnormal_neuroendocrine_gland1.67980228
25MP0002160_abnormal_reproductive_system1.67025601
26MP0002938_white_spotting1.66639912
27MP0003195_calcinosis1.65041011
28MP0003890_abnormal_embryonic-extraembry1.63403111
29MP0005646_abnormal_pituitary_gland1.62723481
30MP0004885_abnormal_endolymph1.61621757
31MP0001529_abnormal_vocalization1.60800247
32MP0008058_abnormal_DNA_repair1.59910768
33MP0003646_muscle_fatigue1.59246144
34MP0001486_abnormal_startle_reflex1.57702582
35MP0005645_abnormal_hypothalamus_physiol1.56209793
36MP0000569_abnormal_digit_pigmentation1.53078315
37MP0002272_abnormal_nervous_system1.49979385
38MP0006276_abnormal_autonomic_nervous1.48058466
39MP0002277_abnormal_respiratory_mucosa1.46394314
40MP0008872_abnormal_physiological_respon1.46107780
41MP0000427_abnormal_hair_cycle1.45126322
42MP0000383_abnormal_hair_follicle1.41308980
43MP0002837_dystrophic_cardiac_calcinosis1.39710565
44MP0003718_maternal_effect1.38450771
45MP0003878_abnormal_ear_physiology1.36892316
46MP0005377_hearing/vestibular/ear_phenot1.36892316
47MP0001986_abnormal_taste_sensitivity1.35259879
48MP0005389_reproductive_system_phenotype1.31717839
49MP0002735_abnormal_chemical_nociception1.30343591
50MP0005394_taste/olfaction_phenotype1.28802681
51MP0005499_abnormal_olfactory_system1.28802681
52MP0000372_irregular_coat_pigmentation1.27458111
53MP0001188_hyperpigmentation1.23653408
54MP0003698_abnormal_male_reproductive1.21294393
55MP0001929_abnormal_gametogenesis1.20751516
56MP0002064_seizures1.19735279
57MP0004742_abnormal_vestibular_system1.19590329
58MP0002572_abnormal_emotion/affect_behav1.18489164
59MP0002557_abnormal_social/conspecific_i1.17706274
60MP0001293_anophthalmia1.16637685
61MP0002234_abnormal_pharynx_morphology1.14135960
62MP0010094_abnormal_chromosome_stability1.13969064
63MP0003937_abnormal_limbs/digits/tail_de1.12062814
64MP0000566_synostosis1.10589832
65MP0000778_abnormal_nervous_system1.10514176
66MP0005386_behavior/neurological_phenoty1.09866042
67MP0004924_abnormal_behavior1.09866042
68MP0000049_abnormal_middle_ear1.09493041
69MP0002734_abnormal_mechanical_nocicepti1.07472352
70MP0003011_delayed_dark_adaptation1.06582189
71MP0002210_abnormal_sex_determination1.06457671
72MP0005174_abnormal_tail_pigmentation1.06141725
73MP0010386_abnormal_urinary_bladder1.04092000
74MP0003121_genomic_imprinting1.03922130
75MP0001501_abnormal_sleep_pattern1.03808704
76MP0001919_abnormal_reproductive_system1.03485561
77MP0002095_abnormal_skin_pigmentation1.03331319
78MP0002067_abnormal_sensory_capabilities1.03067690
79MP0005195_abnormal_posterior_eye1.02685150
80MP0008995_early_reproductive_senescence1.01424060
81MP0005423_abnormal_somatic_nervous1.01210694
82MP0008057_abnormal_DNA_replication1.01092418
83MP0003635_abnormal_synaptic_transmissio1.01003535
84MP0001970_abnormal_pain_threshold1.00541826
85MP0004215_abnormal_myocardial_fiber1.00358393
86MP0002928_abnormal_bile_duct1.00279487
87MP0003119_abnormal_digestive_system0.97003107
88MP0002733_abnormal_thermal_nociception0.96010444
89MP0002063_abnormal_learning/memory/cond0.95620163
90MP0003137_abnormal_impulse_conducting0.95154269
91MP0004145_abnormal_muscle_electrophysio0.95097970
92MP0002752_abnormal_somatic_nervous0.93734615
93MP0002751_abnormal_autonomic_nervous0.93674712
94MP0003122_maternal_imprinting0.93616296
95MP0000653_abnormal_sex_gland0.92111052
96MP0000026_abnormal_inner_ear0.92079002
97MP0005084_abnormal_gallbladder_morpholo0.89403528
98MP0001145_abnormal_male_reproductive0.88787154
99MP0005391_vision/eye_phenotype0.87962234
100MP0001502_abnormal_circadian_rhythm0.86927033

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)4.98478973
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.98478973
3Abnormal respiratory motile cilium morphology (HP:0005938)4.61825746
4Abnormal respiratory epithelium morphology (HP:0012253)4.61825746
5Pancreatic cysts (HP:0001737)4.42660156
6Abnormal ciliary motility (HP:0012262)4.39915829
7Molar tooth sign on MRI (HP:0002419)4.36041540
8Abnormality of midbrain morphology (HP:0002418)4.36041540
9Abnormal respiratory motile cilium physiology (HP:0012261)4.19486829
10True hermaphroditism (HP:0010459)4.19337131
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.19091101
12Pancreatic fibrosis (HP:0100732)4.18522488
13Nephronophthisis (HP:0000090)3.93261473
14Rhinitis (HP:0012384)3.51936289
15Abnormality of the renal medulla (HP:0100957)3.33903826
16Medial flaring of the eyebrow (HP:0010747)3.10640095
17Abnormality of the renal cortex (HP:0011035)3.07360217
18Cystic liver disease (HP:0006706)2.87295728
19Chronic hepatic failure (HP:0100626)2.81917169
20Type II lissencephaly (HP:0007260)2.78694965
21Congenital stationary night blindness (HP:0007642)2.69579703
22Chronic bronchitis (HP:0004469)2.62822966
23Gait imbalance (HP:0002141)2.62472582
24Congenital primary aphakia (HP:0007707)2.55516566
25Bronchiectasis (HP:0002110)2.54387111
26Tubular atrophy (HP:0000092)2.53285807
27Nephrogenic diabetes insipidus (HP:0009806)2.40214543
28Sclerocornea (HP:0000647)2.37761649
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.30117171
30Congenital hepatic fibrosis (HP:0002612)2.27787348
31Postaxial foot polydactyly (HP:0001830)2.27361207
32Anencephaly (HP:0002323)2.22351298
33Pendular nystagmus (HP:0012043)2.22320539
34Renal cortical cysts (HP:0000803)2.21650048
35Polydipsia (HP:0001959)2.21398041
36Abnormal drinking behavior (HP:0030082)2.21398041
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19035199
38Abnormality of alanine metabolism (HP:0010916)2.19035199
39Hyperalaninemia (HP:0003348)2.19035199
40Male pseudohermaphroditism (HP:0000037)2.18512836
41Lissencephaly (HP:0001339)2.17519747
42Furrowed tongue (HP:0000221)2.16688882
43Abolished electroretinogram (ERG) (HP:0000550)2.16505485
44Birth length less than 3rd percentile (HP:0003561)2.15699430
45Colon cancer (HP:0003003)2.11607598
46Genital tract atresia (HP:0001827)2.08107608
47Abnormality of the labia minora (HP:0012880)2.07058018
48Vaginal atresia (HP:0000148)2.06490558
49Cerebellar dysplasia (HP:0007033)2.06097926
50Occipital encephalocele (HP:0002085)2.05832671
51Hyperventilation (HP:0002883)2.04795420
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.04502768
53Abnormal biliary tract physiology (HP:0012439)2.03269663
54Bile duct proliferation (HP:0001408)2.03269663
55Congenital, generalized hypertrichosis (HP:0004540)2.01974089
56Abnormality of the renal collecting system (HP:0004742)2.01184549
57Focal motor seizures (HP:0011153)1.98271676
58Duplicated collecting system (HP:0000081)1.96273456
59Attenuation of retinal blood vessels (HP:0007843)1.96058429
60Abnormality of the pons (HP:0007361)1.94999228
61Preaxial hand polydactyly (HP:0001177)1.93006965
62Postaxial hand polydactyly (HP:0001162)1.92824540
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91865695
64Poor coordination (HP:0002370)1.90057705
65Optic nerve hypoplasia (HP:0000609)1.89360596
66Tubulointerstitial nephritis (HP:0001970)1.88242136
67Supernumerary spleens (HP:0009799)1.87813936
68Decreased central vision (HP:0007663)1.87451518
69Inability to walk (HP:0002540)1.86314219
70Aplasia/Hypoplasia of the spleen (HP:0010451)1.85705351
71Abnormal rod and cone electroretinograms (HP:0008323)1.84302392
72Patellar aplasia (HP:0006443)1.82278912
73Abnormality of the ileum (HP:0001549)1.80926334
74Progressive inability to walk (HP:0002505)1.80205879
75Broad-based gait (HP:0002136)1.79836578
76Oculomotor apraxia (HP:0000657)1.79676627
77Meckel diverticulum (HP:0002245)1.77982277
78Asplenia (HP:0001746)1.76624729
79Large for gestational age (HP:0001520)1.76539086
80Hypoplasia of the pons (HP:0012110)1.74510748
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74217240
82Protruding tongue (HP:0010808)1.73405100
83Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72095981
84Gaze-evoked nystagmus (HP:0000640)1.72055366
85Dandy-Walker malformation (HP:0001305)1.71200915
86Sloping forehead (HP:0000340)1.70131296
87Aplasia/Hypoplasia of the patella (HP:0006498)1.70129504
88Polyuria (HP:0000103)1.68790026
89Febrile seizures (HP:0002373)1.68566235
90Retinal dysplasia (HP:0007973)1.68408996
91Median cleft lip (HP:0000161)1.66871325
92Acute necrotizing encephalopathy (HP:0006965)1.66365635
93Aganglionic megacolon (HP:0002251)1.63891066
94Methylmalonic acidemia (HP:0002912)1.63118776
95Chronic sinusitis (HP:0011109)1.62877613
96Septo-optic dysplasia (HP:0100842)1.61862621
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.60907363
98Intestinal atresia (HP:0011100)1.60690574
99Chromsome breakage (HP:0040012)1.60665418
100Narrow forehead (HP:0000341)1.59890146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.36055188
2WNK32.90125502
3BMPR1B2.87636030
4ZAK2.82041371
5MAPK152.43357520
6PNCK2.27317149
7ADRBK22.20926967
8ACVR1B2.17163063
9GRK12.16134177
10NUAK12.10229113
11MAP4K22.09591102
12TAOK31.98639779
13MKNK21.98188012
14WEE11.91616462
15MAP3K41.91282724
16INSRR1.87767731
17TNIK1.76697941
18MAPK131.73994594
19TLK11.71844004
20PINK11.71632612
21BRSK21.65931748
22CASK1.54258147
23PLK41.51866909
24VRK11.51865983
25WNK41.49157335
26TGFBR11.45972005
27DYRK21.37364966
28MKNK11.37028479
29MUSK1.20961489
30OXSR11.20875927
31TSSK61.16158343
32PLK31.14169300
33TRIM281.12403258
34MARK11.09987098
35CDC71.08617425
36DAPK21.02615922
37MAP2K70.99923218
38STK38L0.99433320
39TAF10.99047195
40PLK20.96740187
41TTK0.95549788
42PRKCG0.93476838
43CSNK1G20.90022920
44ERBB30.86818078
45MST40.86107957
46BCR0.85838761
47NLK0.83916844
48STK390.83889004
49NME10.81938852
50PRKCE0.81448236
51ADRBK10.80568291
52CSNK1G10.78449467
53BCKDK0.77533141
54PLK10.77380517
55STK30.76549309
56SRPK10.76473454
57DYRK30.75174185
58CHEK20.73020596
59CAMKK20.72106599
60TXK0.71871730
61CSNK1G30.71404801
62NEK20.71085953
63EPHA40.68999511
64NTRK30.68994712
65BUB10.66667090
66PAK30.66460905
67VRK20.66442215
68CSNK1A1L0.64759193
69TIE10.61969306
70NTRK20.61577045
71ATR0.60546951
72RPS6KA50.58701248
73PTK2B0.57785290
74MAPKAPK50.55226565
75LATS10.53940501
76FGFR20.53908339
77PASK0.51923841
78MAPKAPK30.51233294
79DYRK1A0.49251637
80ATM0.49037281
81PHKG10.48835579
82PHKG20.48835579
83IRAK10.47104621
84CDK30.45770982
85CDK190.45466300
86AKT30.43561656
87CAMK2A0.43398368
88PKN10.42196720
89KIT0.40409737
90PRKCQ0.40162288
91UHMK10.38983609
92CSNK1D0.38058159
93OBSCN0.38003863
94PRKACA0.37694604
95CSNK1A10.37261843
96STK110.36903124
97ERBB20.34956710
98SGK20.34202989
99TEC0.32803566
100GRK50.31614682

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.59036591
2Linoleic acid metabolism_Homo sapiens_hsa005912.51985321
3Nitrogen metabolism_Homo sapiens_hsa009102.48884030
4Nicotine addiction_Homo sapiens_hsa050332.42011000
5Homologous recombination_Homo sapiens_hsa034402.30998836
6Fanconi anemia pathway_Homo sapiens_hsa034602.29001200
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27980973
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.22956908
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20994085
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02164448
11Butanoate metabolism_Homo sapiens_hsa006501.98712542
12Oxidative phosphorylation_Homo sapiens_hsa001901.96746214
13Basal transcription factors_Homo sapiens_hsa030221.95562503
14Selenocompound metabolism_Homo sapiens_hsa004501.85661673
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85399270
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81063250
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80054864
18Protein export_Homo sapiens_hsa030601.78125461
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77450987
20RNA polymerase_Homo sapiens_hsa030201.77386143
21RNA degradation_Homo sapiens_hsa030181.69112982
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63956499
23Ether lipid metabolism_Homo sapiens_hsa005651.61533061
24Huntingtons disease_Homo sapiens_hsa050161.60573851
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.59879810
26Taste transduction_Homo sapiens_hsa047421.58270175
27One carbon pool by folate_Homo sapiens_hsa006701.57361573
28Caffeine metabolism_Homo sapiens_hsa002321.56911822
29Parkinsons disease_Homo sapiens_hsa050121.53623460
30Propanoate metabolism_Homo sapiens_hsa006401.41478730
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32278769
32Chemical carcinogenesis_Homo sapiens_hsa052041.30017691
33Tryptophan metabolism_Homo sapiens_hsa003801.28620489
34Olfactory transduction_Homo sapiens_hsa047401.28437787
35Ribosome_Homo sapiens_hsa030101.19890372
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19617855
37Mismatch repair_Homo sapiens_hsa034301.18096224
38Morphine addiction_Homo sapiens_hsa050321.16487768
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13345788
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10973035
41Non-homologous end-joining_Homo sapiens_hsa034501.10346976
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10112430
43Peroxisome_Homo sapiens_hsa041461.07879949
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07658951
45Histidine metabolism_Homo sapiens_hsa003401.00948239
46GABAergic synapse_Homo sapiens_hsa047271.00824718
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00429191
48Cardiac muscle contraction_Homo sapiens_hsa042600.95910932
49Arachidonic acid metabolism_Homo sapiens_hsa005900.94350440
50Alzheimers disease_Homo sapiens_hsa050100.92872510
51Nucleotide excision repair_Homo sapiens_hsa034200.91218373
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.90868203
53Retinol metabolism_Homo sapiens_hsa008300.90234288
54Serotonergic synapse_Homo sapiens_hsa047260.89821110
55Glutamatergic synapse_Homo sapiens_hsa047240.89584832
56RNA transport_Homo sapiens_hsa030130.88297735
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88174412
58beta-Alanine metabolism_Homo sapiens_hsa004100.88087824
59Purine metabolism_Homo sapiens_hsa002300.86390896
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.83141025
61ABC transporters_Homo sapiens_hsa020100.82901969
62Regulation of autophagy_Homo sapiens_hsa041400.81895979
63Circadian entrainment_Homo sapiens_hsa047130.80839922
64Steroid biosynthesis_Homo sapiens_hsa001000.80315275
65Basal cell carcinoma_Homo sapiens_hsa052170.77090583
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75851612
67Insulin secretion_Homo sapiens_hsa049110.72312449
68Hedgehog signaling pathway_Homo sapiens_hsa043400.71275053
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71155518
70Sulfur relay system_Homo sapiens_hsa041220.69884083
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.69495124
72Base excision repair_Homo sapiens_hsa034100.69325223
73Circadian rhythm_Homo sapiens_hsa047100.65182045
74Pyrimidine metabolism_Homo sapiens_hsa002400.64176326
75Spliceosome_Homo sapiens_hsa030400.64148545
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61742763
77Salivary secretion_Homo sapiens_hsa049700.61144091
78Metabolic pathways_Homo sapiens_hsa011000.59105718
79Calcium signaling pathway_Homo sapiens_hsa040200.58868854
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55513732
81Dorso-ventral axis formation_Homo sapiens_hsa043200.55054360
82Collecting duct acid secretion_Homo sapiens_hsa049660.55000672
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50688977
84Glycerolipid metabolism_Homo sapiens_hsa005610.48681917
85DNA replication_Homo sapiens_hsa030300.47572232
86Ovarian steroidogenesis_Homo sapiens_hsa049130.45588896
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.44989493
88Vitamin digestion and absorption_Homo sapiens_hsa049770.43859301
89Dopaminergic synapse_Homo sapiens_hsa047280.40637508
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40450705
91Alcoholism_Homo sapiens_hsa050340.40324170
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40273541
93Oocyte meiosis_Homo sapiens_hsa041140.38709882
94p53 signaling pathway_Homo sapiens_hsa041150.38263548
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36958888
96Proteasome_Homo sapiens_hsa030500.36927307
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36660232
98Long-term depression_Homo sapiens_hsa047300.35503547
99Amphetamine addiction_Homo sapiens_hsa050310.33768243
100Fatty acid degradation_Homo sapiens_hsa000710.33467934

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