ZNF274

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)4.68750972
2positive regulation of gamma-delta T cell activation (GO:0046645)4.57529243
3histone H3-K9 methylation (GO:0051567)4.13928508
4histone H3-K9 modification (GO:0061647)4.07154339
5regulation of gamma-delta T cell activation (GO:0046643)3.67368203
6negative regulation of mast cell activation (GO:0033004)3.62606829
7cellular response to exogenous dsRNA (GO:0071360)3.58194576
8interferon-gamma production (GO:0032609)3.52486509
9activated T cell proliferation (GO:0050798)3.50205920
10protein K11-linked deubiquitination (GO:0035871)3.34556504
11regulation of gamma-delta T cell differentiation (GO:0045586)3.34043763
12positive regulation of granulocyte differentiation (GO:0030854)3.29601917
13neural tube formation (GO:0001841)3.27096844
14rRNA catabolic process (GO:0016075)3.24947339
15negative regulation of telomere maintenance (GO:0032205)3.13821472
16defense response to protozoan (GO:0042832)3.12506445
17basic amino acid transport (GO:0015802)3.10229067
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07143987
19negative regulation of cell killing (GO:0031342)3.07143987
20regulation of T cell tolerance induction (GO:0002664)3.04786264
21dosage compensation (GO:0007549)3.04258034
22regulation of mast cell activation (GO:0033003)3.00576388
23response to protozoan (GO:0001562)3.00255028
24protein K63-linked deubiquitination (GO:0070536)2.99353402
25regulation of T cell cytokine production (GO:0002724)2.98631100
26histone H3-K4 trimethylation (GO:0080182)2.95840414
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94494048
28positive regulation of mast cell activation (GO:0033005)2.94174343
29monoubiquitinated protein deubiquitination (GO:0035520)2.92442216
30granulocyte differentiation (GO:0030851)2.90758038
31positive regulation of defense response to virus by host (GO:0002230)2.89397107
32regulation of B cell receptor signaling pathway (GO:0050855)2.87469041
33negative thymic T cell selection (GO:0045060)2.85139355
34negative regulation of interleukin-6 production (GO:0032715)2.82497031
35B cell receptor signaling pathway (GO:0050853)2.81592850
36pyrimidine nucleobase catabolic process (GO:0006208)2.81344292
37positive regulation of protein homooligomerization (GO:0032464)2.78612330
38negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77500485
39necrotic cell death (GO:0070265)2.76597784
40maintenance of protein location in nucleus (GO:0051457)2.74454144
41negative T cell selection (GO:0043383)2.73029973
42regulation of tolerance induction (GO:0002643)2.71132853
43tryptophan metabolic process (GO:0006568)2.70863128
44regulation of mast cell activation involved in immune response (GO:0033006)2.70216574
45negative regulation of interleukin-12 production (GO:0032695)2.69755012
46indolalkylamine metabolic process (GO:0006586)2.69264736
47histone H4-K16 acetylation (GO:0043984)2.68937084
48positive regulation of natural killer cell differentiation (GO:0032825)2.68613267
49regulation of T cell mediated immunity (GO:0002709)2.66555197
50erythrocyte development (GO:0048821)2.64782789
51programmed necrotic cell death (GO:0097300)2.63944448
52positive regulation by symbiont of host defense response (GO:0052509)2.62294370
53modulation by symbiont of host defense response (GO:0052031)2.62294370
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62294370
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62294370
56positive regulation by organism of defense response of other organism involved in symbiotic interact2.62294370
57modulation by symbiont of host immune response (GO:0052553)2.62294370
58behavioral response to nicotine (GO:0035095)2.61749897
59negative regulation of T cell mediated immunity (GO:0002710)2.61407761
60positive regulation by host of viral transcription (GO:0043923)2.59679316
61protein K48-linked deubiquitination (GO:0071108)2.59336868
62response to muramyl dipeptide (GO:0032495)2.58936792
63neutrophil mediated immunity (GO:0002446)2.58535146
64regulation of defense response to virus by host (GO:0050691)2.58460146
65regulation of MHC class I biosynthetic process (GO:0045343)2.56728931
66regulation of telomere maintenance (GO:0032204)2.56391809
67peptidyl-lysine methylation (GO:0018022)2.55958546
68positive regulation of B cell differentiation (GO:0045579)2.55378328
69positive T cell selection (GO:0043368)2.54481542
70histone lysine methylation (GO:0034968)2.53397601
71peptidyl-lysine trimethylation (GO:0018023)2.53108683
72positive regulation of mast cell degranulation (GO:0043306)2.53081598
73positive regulation of mast cell activation involved in immune response (GO:0033008)2.53081598
74tolerance induction (GO:0002507)2.52796959
75antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51355855
76mannose metabolic process (GO:0006013)2.51224454
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50742564
78regulation of mast cell degranulation (GO:0043304)2.50338768
79regulation of interferon-beta biosynthetic process (GO:0045357)2.49704151
80I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.49632533
81positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49446203
82CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.49223508
83regulation of natural killer cell mediated immunity (GO:0002715)2.48471192
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.48471192
85negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.48241438
86regulation of T cell mediated cytotoxicity (GO:0001914)2.48032177
87regulation of granulocyte differentiation (GO:0030852)2.47441751
88CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.47166849
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.46717610
90positive regulation of CREB transcription factor activity (GO:0032793)2.46086315
91regulation of interleukin-12 biosynthetic process (GO:0045075)2.45855870
92indole-containing compound catabolic process (GO:0042436)2.45688249
93indolalkylamine catabolic process (GO:0046218)2.45688249
94tryptophan catabolic process (GO:0006569)2.45688249
95positive regulation of histone deacetylation (GO:0031065)2.44876826
96meiotic chromosome segregation (GO:0045132)2.44464925
97alpha-beta T cell differentiation (GO:0046632)2.44264378
98negative regulation of cAMP-mediated signaling (GO:0043951)2.44194516
99germinal center formation (GO:0002467)2.43027135
100histone H4-K5 acetylation (GO:0043981)2.41655762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.79255756
2ZNF274_21170338_ChIP-Seq_K562_Hela3.71352661
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.52713435
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13992305
5EZH2_22144423_ChIP-Seq_EOC_Human3.07712922
6CIITA_25753668_ChIP-Seq_RAJI_Human2.95742059
7IRF1_19129219_ChIP-ChIP_H3396_Human2.70522929
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.46083118
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.37934850
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33730019
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26920560
12MYB_26560356_Chip-Seq_TH2_Human2.15820976
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15129978
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14368026
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07016123
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04666238
17VDR_23849224_ChIP-Seq_CD4+_Human1.92777257
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92281186
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88886832
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84589271
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82925245
22MYB_26560356_Chip-Seq_TH1_Human1.82461645
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.82197937
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80602065
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.80525113
26RUNX_20019798_ChIP-Seq_JUKART_Human1.78999752
27MAF_26560356_Chip-Seq_TH2_Human1.75029392
28GATA3_26560356_Chip-Seq_TH2_Human1.74437591
29* SPI1_23547873_ChIP-Seq_NB4_Human1.72734294
30MYC_22102868_ChIP-Seq_BL_Human1.67220683
31SCL_19346495_ChIP-Seq_HPC-7_Human1.64852936
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63182876
33GATA3_27048872_Chip-Seq_THYMUS_Human1.63169705
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.61349791
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61085442
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57558531
37UTX_26944678_Chip-Seq_JUKART_Human1.56404480
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54015154
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53546045
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53374134
41KDM5A_27292631_Chip-Seq_BREAST_Human1.53243098
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52362481
43* MAF_26560356_Chip-Seq_TH1_Human1.51654175
44* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46913845
45VDR_21846776_ChIP-Seq_THP-1_Human1.46889876
46BCL6_27268052_Chip-Seq_Bcells_Human1.44819137
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41907540
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39820003
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.35769975
50SPI1_23127762_ChIP-Seq_K562_Human1.35236714
51GATA1_22025678_ChIP-Seq_K562_Human1.33615002
52ERA_21632823_ChIP-Seq_H3396_Human1.32044257
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31567218
54GABP_19822575_ChIP-Seq_HepG2_Human1.31150620
55BCOR_27268052_Chip-Seq_Bcells_Human1.31012147
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30435768
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.30199658
58P300_27268052_Chip-Seq_Bcells_Human1.29683639
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27652560
60PHF8_20622854_ChIP-Seq_HELA_Human1.25837217
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25819852
62FOXP3_21729870_ChIP-Seq_TREG_Human1.24152056
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20613071
64RAC3_21632823_ChIP-Seq_H3396_Human1.16392038
65P68_20966046_ChIP-Seq_HELA_Human1.16193926
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15622213
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14799408
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14786281
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12128996
70E2F1_20622854_ChIP-Seq_HELA_Human1.12073612
71IGF1R_20145208_ChIP-Seq_DFB_Human1.10633608
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.10382679
73SMRT_27268052_Chip-Seq_Bcells_Human1.08793239
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08644378
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06826055
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05899669
77GATA1_19941826_ChIP-Seq_K562_Human1.05499941
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04777091
79TP53_22573176_ChIP-Seq_HFKS_Human1.04498494
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03906480
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.02617123
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.01623693
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.01466751
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.00654248
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00055125
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99702079
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99332595
88WDR5_24793694_ChIP-Seq_LNCAP_Human0.99020579
89ER_23166858_ChIP-Seq_MCF-7_Human0.98600961
90* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.97516311
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97025122
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94075993
93OCT4_20526341_ChIP-Seq_ESCs_Human0.92796498
94KDM2B_26808549_Chip-Seq_DND41_Human0.91900950
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91686857
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90976926
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89300706
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89005480
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88804192
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88804192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to2.68211712
2MP0001800_abnormal_humoral_immune2.57776321
3MP0002138_abnormal_hepatobiliary_system2.51153552
4MP0003724_increased_susceptibility_to2.50550748
5MP0005671_abnormal_response_to2.44514930
6MP0003303_peritoneal_inflammation2.43212995
7MP0009278_abnormal_bone_marrow2.42447814
8MP0005387_immune_system_phenotype2.32407491
9MP0001790_abnormal_immune_system2.32407491
10MP0003787_abnormal_imprinting2.31900837
11MP0001835_abnormal_antigen_presentation2.27625133
12MP0002132_abnormal_respiratory_system2.25895951
13MP0003763_abnormal_thymus_physiology2.23544333
14MP0001545_abnormal_hematopoietic_system2.16755962
15MP0005397_hematopoietic_system_phenotyp2.16755962
16MP0002723_abnormal_immune_serum2.16447854
17MP0008877_abnormal_DNA_methylation2.05053781
18MP0003646_muscle_fatigue2.04893005
19MP0008057_abnormal_DNA_replication1.99056532
20MP0000685_abnormal_immune_system1.98995473
21MP0002452_abnormal_antigen_presenting1.97581456
22MP0005000_abnormal_immune_tolerance1.90168482
23MP0002420_abnormal_adaptive_immunity1.83500236
24MP0001819_abnormal_immune_cell1.81805564
25MP0002419_abnormal_innate_immunity1.73086251
26MP0000716_abnormal_immune_system1.69317778
27MP0002398_abnormal_bone_marrow1.68677818
28MP0005025_abnormal_response_to1.68320635
29MP0002148_abnormal_hypersensitivity_rea1.66477683
30MP0008995_early_reproductive_senescence1.66469168
31MP0000689_abnormal_spleen_morphology1.62667655
32MP0002653_abnormal_ependyma_morphology1.61460397
33MP0005167_abnormal_blood-brain_barrier1.61318937
34MP0003656_abnormal_erythrocyte_physiolo1.61178881
35MP0001873_stomach_inflammation1.59576316
36MP0002405_respiratory_system_inflammati1.56159679
37MP0009785_altered_susceptibility_to1.55678423
38MP0009764_decreased_sensitivity_to1.55011413
39MP0009333_abnormal_splenocyte_physiolog1.49813053
40MP0004147_increased_porphyrin_level1.48482917
41MP0008058_abnormal_DNA_repair1.46064475
42MP0002722_abnormal_immune_system1.46000342
43MP0000569_abnormal_digit_pigmentation1.42976554
44MP0000703_abnormal_thymus_morphology1.40800763
45MP0008961_abnormal_basal_metabolism1.36274907
46MP0003172_abnormal_lysosome_physiology1.34038331
47MP0002429_abnormal_blood_cell1.33319167
48MP0002928_abnormal_bile_duct1.28682698
49MP0004142_abnormal_muscle_tone1.27085752
50MP0005075_abnormal_melanosome_morpholog1.24386132
51MP0003183_abnormal_peptide_metabolism1.22525029
52MP0002277_abnormal_respiratory_mucosa1.20502917
53MP0005310_abnormal_salivary_gland1.18918531
54MP0001764_abnormal_homeostasis1.16942831
55MP0004043_abnormal_pH_regulation1.15135776
56MP0001661_extended_life_span1.15011970
57MP0008872_abnormal_physiological_respon1.14038601
58MP0001845_abnormal_inflammatory_respons1.10423398
59MP0006276_abnormal_autonomic_nervous1.08405102
60MP0003195_calcinosis1.07598196
61MP0002837_dystrophic_cardiac_calcinosis1.05268574
62MP0003121_genomic_imprinting1.04179011
63MP0008469_abnormal_protein_level1.03248927
64MP0003828_pulmonary_edema1.01025202
65MP0009115_abnormal_fat_cell0.99733348
66MP0008875_abnormal_xenobiotic_pharmacok0.98593507
67MP0002332_abnormal_exercise_endurance0.96809722
68MP0001919_abnormal_reproductive_system0.96198172
69MP0005266_abnormal_metabolism0.94651777
70MP0002102_abnormal_ear_morphology0.94262619
71MP0001986_abnormal_taste_sensitivity0.93888844
72MP0004130_abnormal_muscle_cell0.93777183
73MP0004947_skin_inflammation0.91351771
74MP0005448_abnormal_energy_balance0.90430031
75MP0004381_abnormal_hair_follicle0.88396385
76MP0005645_abnormal_hypothalamus_physiol0.84847743
77MP0006082_CNS_inflammation0.84372589
78MP0004808_abnormal_hematopoietic_stem0.83893079
79MP0001663_abnormal_digestive_system0.83560058
80MP0005334_abnormal_fat_pad0.82002440
81MP0009840_abnormal_foam_cell0.79590511
82MP0003221_abnormal_cardiomyocyte_apopto0.78185808
83MP0009765_abnormal_xenobiotic_induced0.76769215
84MP0010155_abnormal_intestine_physiology0.76158250
85MP0008260_abnormal_autophagy0.73601223
86MP0004742_abnormal_vestibular_system0.73554872
87MP0001533_abnormal_skeleton_physiology0.72904686
88MP0006035_abnormal_mitochondrial_morpho0.72200050
89MP0002009_preneoplasia0.67247929
90MP0000371_diluted_coat_color0.66092895
91MP0003698_abnormal_male_reproductive0.65820913
92MP0001853_heart_inflammation0.64431905
93MP0005389_reproductive_system_phenotype0.63679316
94MP0000778_abnormal_nervous_system0.63205233
95MP0005376_homeostasis/metabolism_phenot0.62684275
96MP0000465_gastrointestinal_hemorrhage0.60988934
97MP0000015_abnormal_ear_pigmentation0.60964587
98MP0001501_abnormal_sleep_pattern0.60314187
99MP0005410_abnormal_fertilization0.59024899
100MP0005058_abnormal_lysosome_morphology0.58312330

Predicted human phenotypes

RankGene SetZ-score
1Protruding tongue (HP:0010808)3.64660463
2Abnormal delayed hypersensitivity skin test (HP:0002963)3.48156838
3Optic neuritis (HP:0100653)3.25122741
4Retrobulbar optic neuritis (HP:0100654)3.25122741
5Panhypogammaglobulinemia (HP:0003139)3.20677121
6Recurrent fungal infections (HP:0002841)2.97662174
7Absent rod-and cone-mediated responses on ERG (HP:0007688)2.96689809
8Stomatitis (HP:0010280)2.96590787
9Eczematoid dermatitis (HP:0000976)2.90505165
10Hypoplastic iliac wings (HP:0002866)2.87695429
11Recurrent bacterial skin infections (HP:0005406)2.86644458
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.79290152
13Myositis (HP:0100614)2.76439595
14Orchitis (HP:0100796)2.75996293
15Elevated erythrocyte sedimentation rate (HP:0003565)2.73431648
16Hyperventilation (HP:0002883)2.69917964
17Recurrent cutaneous fungal infections (HP:0011370)2.60076538
18Chronic mucocutaneous candidiasis (HP:0002728)2.60076538
19Congenital stationary night blindness (HP:0007642)2.58749024
20Attenuation of retinal blood vessels (HP:0007843)2.56922277
21Encephalitis (HP:0002383)2.51901347
22Lissencephaly (HP:0001339)2.49076467
23Abnormal rod and cone electroretinograms (HP:0008323)2.48950756
24Absent speech (HP:0001344)2.45200351
25IgG deficiency (HP:0004315)2.43108147
26Pustule (HP:0200039)2.41048278
27Abnormality of T cell physiology (HP:0011840)2.38410012
28Stomach cancer (HP:0012126)2.37466904
29Pancreatic cysts (HP:0001737)2.35873959
30Widely spaced teeth (HP:0000687)2.30729188
31Severe combined immunodeficiency (HP:0004430)2.28984585
32Clumsiness (HP:0002312)2.27807042
33Macroglossia (HP:0000158)2.27645516
34Genetic anticipation (HP:0003743)2.27403935
35Molar tooth sign on MRI (HP:0002419)2.24486303
36Abnormality of midbrain morphology (HP:0002418)2.24486303
37Recurrent abscess formation (HP:0002722)2.23486455
38Mediastinal lymphadenopathy (HP:0100721)2.22800286
39Keratoconjunctivitis (HP:0001096)2.22139616
40Abnormality of the fingertips (HP:0001211)2.20954927
41Abnormal protein glycosylation (HP:0012346)2.15310645
42Abnormal glycosylation (HP:0012345)2.15310645
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15310645
44Abnormal protein N-linked glycosylation (HP:0012347)2.15310645
45Broad alveolar ridges (HP:0000187)2.12765657
46Keratoconjunctivitis sicca (HP:0001097)2.12281092
47Autoimmune thrombocytopenia (HP:0001973)2.12209628
48Bile duct proliferation (HP:0001408)2.12002340
49Abnormal biliary tract physiology (HP:0012439)2.12002340
50Vacuolated lymphocytes (HP:0001922)2.11796219
51Abnormality of T cells (HP:0002843)2.11617561
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.08846407
53Abnormality of the renal collecting system (HP:0004742)2.08506608
54Pancreatic fibrosis (HP:0100732)2.06475737
55Recurrent viral infections (HP:0004429)2.05425357
56Increased IgE level (HP:0003212)2.04146414
57Recurrent skin infections (HP:0001581)2.00481893
58Type II lissencephaly (HP:0007260)1.99575849
59Duplicated collecting system (HP:0000081)1.96183590
60Chronic hepatic failure (HP:0100626)1.96137217
61Medial flaring of the eyebrow (HP:0010747)1.95171205
62True hermaphroditism (HP:0010459)1.95043867
63Meningitis (HP:0001287)1.93882459
64Deep palmar crease (HP:0006191)1.91437684
65Alveolar cell carcinoma (HP:0006519)1.91246325
66Abnormality of DNA repair (HP:0003254)1.90843202
67Abnormality of T cell number (HP:0011839)1.90295452
68Nephrogenic diabetes insipidus (HP:0009806)1.89995455
69Increased neuronal autofluorescent lipopigment (HP:0002074)1.89655207
70Abnormality of the renal medulla (HP:0100957)1.88525443
71Nephronophthisis (HP:0000090)1.88154604
72Brushfield spots (HP:0001088)1.86901765
73Abnormality of dental color (HP:0011073)1.86258542
74Abnormality of transition element cation homeostasis (HP:0011030)1.85389497
75Neoplasm of the tracheobronchial system (HP:0100552)1.84950212
76Polydipsia (HP:0001959)1.84346146
77Abnormal drinking behavior (HP:0030082)1.84346146
78Agammaglobulinemia (HP:0004432)1.83610921
79Abnormality of the renal cortex (HP:0011035)1.82022740
80Abnormality of the pons (HP:0007361)1.81754172
81Hypochromic anemia (HP:0001931)1.81559465
82Amyotrophic lateral sclerosis (HP:0007354)1.81061645
83Failure to thrive in infancy (HP:0001531)1.80567244
84Progressive cerebellar ataxia (HP:0002073)1.80041074
85T lymphocytopenia (HP:0005403)1.79639130
86Abnormality of eosinophils (HP:0001879)1.79537796
87Recurrent sinusitis (HP:0011108)1.78945387
88Pachygyria (HP:0001302)1.74235401
89Increased cerebral lipofuscin (HP:0011813)1.72631435
90Thyroiditis (HP:0100646)1.70575617
91Abnormality of macrophages (HP:0004311)1.70092630
92Basal cell carcinoma (HP:0002671)1.68800597
93Impulsivity (HP:0100710)1.67057401
94Abnormality of liposaccharide metabolism (HP:0010968)1.66194027
95Abnormality of glycosphingolipid metabolism (HP:0004343)1.66194027
96Abnormality of glycolipid metabolism (HP:0010969)1.66194027
97Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.66152874
98Hypoplasia of the pons (HP:0012110)1.65865754
99Adactyly (HP:0009776)1.65535088
100Vasculitis (HP:0002633)1.65334012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK23.95658449
2EPHA32.97843019
3FRK2.63541486
4CDK122.47417903
5TXK2.42247274
6MAP4K12.28901972
7TRIM282.13039233
8RIPK41.89465190
9IRAK11.88976993
10MARK31.87034110
11TAOK31.85303697
12IRAK41.78510532
13BCKDK1.72373759
14WNK31.59848232
15MAP3K111.59790939
16ADRBK21.58300450
17MAP2K71.57784245
18TLK11.55237679
19IKBKE1.53918997
20DYRK1B1.51450682
21BMPR1B1.50934127
22IKBKB1.47188429
23MAP2K41.42716263
24CHUK1.41207877
25MAP3K41.39063751
26SIK31.37435761
27BLK1.35903999
28BTK1.31273196
29BRD41.28729309
30MAP3K141.25382473
31PIM11.23512718
32MAP4K21.19194677
33MAP3K61.16902045
34TNK21.14750762
35TRPM71.12460504
36TYK21.11562023
37SYK1.09672545
38DAPK21.04696386
39PINK11.04414904
40MAP3K71.03898172
41MAP3K101.02520561
42GRK61.01554326
43AKT31.01449606
44CSF1R0.98263387
45TBK10.97435684
46CAMK1D0.97010316
47BMPR20.96962429
48NLK0.94051828
49JAK20.92942887
50HIPK20.92290647
51KIT0.89332409
52JAK30.88675887
53ZAK0.88329770
54CAMK1G0.87978757
55MAPK130.87614820
56BCR0.85410473
57LCK0.83873794
58MARK20.83784634
59MAP3K50.83288701
60WNK40.83159669
61HCK0.82771917
62EPHB10.82282246
63ZAP700.81595570
64ITK0.81497177
65ERN10.77902494
66LYN0.77897023
67CAMKK20.76253811
68PDK20.73324238
69EEF2K0.73274561
70FES0.73154671
71PRKCZ0.72443826
72ACVR1B0.71661006
73MATK0.70306595
74TESK20.70079434
75RPS6KA60.69722695
76TEC0.65640347
77STK110.64583709
78RPS6KA50.60574223
79MAP3K10.60050701
80CSK0.58762866
81GRK70.58723393
82DYRK20.58179992
83PRKAA10.57189170
84CAMKK10.54685398
85PIM20.50951258
86PRKD20.50592736
87RPS6KC10.48888234
88RPS6KL10.48888234
89RPS6KA10.48022225
90CAMK40.46611699
91MAP2K20.45638203
92KSR10.45334904
93MAP2K60.43473465
94MAPK150.43393755
95PDK10.42028840
96MAPKAPK30.41597905
97PRKCQ0.41396740
98DYRK30.41016830
99FGR0.39639025
100PRKCI0.39587281

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046722.84433498
2Primary immunodeficiency_Homo sapiens_hsa053402.66747006
3Asthma_Homo sapiens_hsa053102.62857644
4Allograft rejection_Homo sapiens_hsa053302.56017173
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.38483004
6Graft-versus-host disease_Homo sapiens_hsa053322.28608702
7Autoimmune thyroid disease_Homo sapiens_hsa053202.21048327
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.16300425
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13228540
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02984510
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.02268041
12Other glycan degradation_Homo sapiens_hsa005111.98010206
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.92175563
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84733681
15Leishmaniasis_Homo sapiens_hsa051401.80294975
16Osteoclast differentiation_Homo sapiens_hsa043801.74107238
17TNF signaling pathway_Homo sapiens_hsa046681.73011614
18Type I diabetes mellitus_Homo sapiens_hsa049401.72899615
19B cell receptor signaling pathway_Homo sapiens_hsa046621.72542562
20Linoleic acid metabolism_Homo sapiens_hsa005911.67604222
21Regulation of autophagy_Homo sapiens_hsa041401.60107931
22Selenocompound metabolism_Homo sapiens_hsa004501.57856881
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52962902
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.48217868
25Tuberculosis_Homo sapiens_hsa051521.47499202
26T cell receptor signaling pathway_Homo sapiens_hsa046601.36258715
27Staphylococcus aureus infection_Homo sapiens_hsa051501.35040280
28Hematopoietic cell lineage_Homo sapiens_hsa046401.27206913
29Herpes simplex infection_Homo sapiens_hsa051681.26624430
30Influenza A_Homo sapiens_hsa051641.26559452
31Acute myeloid leukemia_Homo sapiens_hsa052211.24477036
32Ether lipid metabolism_Homo sapiens_hsa005651.22299382
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20136285
34Rheumatoid arthritis_Homo sapiens_hsa053231.17409958
35Measles_Homo sapiens_hsa051621.14992180
36Hepatitis B_Homo sapiens_hsa051611.13504731
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12975555
38Legionellosis_Homo sapiens_hsa051341.12471983
39Lysosome_Homo sapiens_hsa041421.09607417
40Antigen processing and presentation_Homo sapiens_hsa046121.09599196
41Dorso-ventral axis formation_Homo sapiens_hsa043201.07002498
42Basal transcription factors_Homo sapiens_hsa030221.05562511
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03420407
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.00600251
45Toxoplasmosis_Homo sapiens_hsa051450.99696453
46Viral myocarditis_Homo sapiens_hsa054160.94739333
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90754501
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90678207
49mTOR signaling pathway_Homo sapiens_hsa041500.85975637
50ABC transporters_Homo sapiens_hsa020100.85973602
51Fanconi anemia pathway_Homo sapiens_hsa034600.81152461
52Caffeine metabolism_Homo sapiens_hsa002320.80364336
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79803422
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79219565
55African trypanosomiasis_Homo sapiens_hsa051430.78928270
56FoxO signaling pathway_Homo sapiens_hsa040680.78917647
57Viral carcinogenesis_Homo sapiens_hsa052030.78798330
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76641858
59Hepatitis C_Homo sapiens_hsa051600.76491885
60Chemokine signaling pathway_Homo sapiens_hsa040620.75836875
61RNA degradation_Homo sapiens_hsa030180.75480817
62Lysine degradation_Homo sapiens_hsa003100.75469650
63Systemic lupus erythematosus_Homo sapiens_hsa053220.75120035
64Phototransduction_Homo sapiens_hsa047440.74815127
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74603554
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74101224
67Apoptosis_Homo sapiens_hsa042100.73810074
68Epstein-Barr virus infection_Homo sapiens_hsa051690.73461997
69Choline metabolism in cancer_Homo sapiens_hsa052310.73190576
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71403956
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.70687398
72Phagosome_Homo sapiens_hsa041450.69750763
73VEGF signaling pathway_Homo sapiens_hsa043700.67245436
74Insulin resistance_Homo sapiens_hsa049310.67088268
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.66817497
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60840762
77Butanoate metabolism_Homo sapiens_hsa006500.59426551
78Prolactin signaling pathway_Homo sapiens_hsa049170.57940857
79Homologous recombination_Homo sapiens_hsa034400.53241681
80Olfactory transduction_Homo sapiens_hsa047400.52868213
81Collecting duct acid secretion_Homo sapiens_hsa049660.52377668
82MAPK signaling pathway_Homo sapiens_hsa040100.51730102
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51710680
84Malaria_Homo sapiens_hsa051440.50460948
85Arachidonic acid metabolism_Homo sapiens_hsa005900.48963731
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47305833
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44427640
88Taste transduction_Homo sapiens_hsa047420.44292110
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44138964
90ErbB signaling pathway_Homo sapiens_hsa040120.43637100
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.41683647
92Morphine addiction_Homo sapiens_hsa050320.41679909
93Long-term depression_Homo sapiens_hsa047300.41067112
94Salmonella infection_Homo sapiens_hsa051320.39984267
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39440452
96Spliceosome_Homo sapiens_hsa030400.39224894
97Type II diabetes mellitus_Homo sapiens_hsa049300.38417966
98Pertussis_Homo sapiens_hsa051330.36779944
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36549405
100Ovarian steroidogenesis_Homo sapiens_hsa049130.33873025

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