ZNF276

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.78926845
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.78926845
3positive regulation of gamma-delta T cell activation (GO:0046645)5.66618588
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.14348599
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07068106
6antigen processing and presentation of endogenous antigen (GO:0019883)4.91371500
7positive thymic T cell selection (GO:0045059)4.86425526
8positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.76093229
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.71878710
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.50036031
11negative thymic T cell selection (GO:0045060)4.41994171
12regulation of gamma-delta T cell activation (GO:0046643)4.41974022
13positive T cell selection (GO:0043368)4.37630956
14negative regulation of erythrocyte differentiation (GO:0045647)4.36982406
15negative T cell selection (GO:0043383)4.36642407
16regulation of gamma-delta T cell differentiation (GO:0045586)4.30695123
17leukocyte aggregation (GO:0070486)4.30648938
18mannose metabolic process (GO:0006013)4.24201304
19thymic T cell selection (GO:0045061)4.22588998
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22409079
21G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.15715397
22regulation of B cell receptor signaling pathway (GO:0050855)4.14781622
23T cell selection (GO:0045058)4.03005381
24positive regulation by symbiont of host defense response (GO:0052509)3.93935365
25modulation by symbiont of host defense response (GO:0052031)3.93935365
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.93935365
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.93935365
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.93935365
29modulation by symbiont of host immune response (GO:0052553)3.93935365
30detection of other organism (GO:0098543)3.89143729
31response to muramyl dipeptide (GO:0032495)3.88810534
32detection of bacterium (GO:0016045)3.87868191
33interferon-gamma production (GO:0032609)3.79989887
34response to interleukin-15 (GO:0070672)3.78786497
35response to peptidoglycan (GO:0032494)3.78583028
36regulation of interferon-beta biosynthetic process (GO:0045357)3.75914760
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.70275060
38purinergic nucleotide receptor signaling pathway (GO:0035590)3.67239277
39macrophage activation involved in immune response (GO:0002281)3.62174218
40negative regulation of T cell mediated immunity (GO:0002710)3.58589002
41cellular extravasation (GO:0045123)3.51715466
42activated T cell proliferation (GO:0050798)3.48358181
43tolerance induction (GO:0002507)3.47266289
44B cell receptor signaling pathway (GO:0050853)3.43287075
45adenosine receptor signaling pathway (GO:0001973)3.39384275
46cellular response to ATP (GO:0071318)3.38611461
47cellular response to interleukin-15 (GO:0071350)3.33779697
48negative regulation of leukocyte mediated immunity (GO:0002704)3.33281828
49detection of external biotic stimulus (GO:0098581)3.30718507
50negative regulation of innate immune response (GO:0045824)3.29296896
51T cell migration (GO:0072678)3.28130933
52neutrophil activation involved in immune response (GO:0002283)3.23547648
53GDP-mannose metabolic process (GO:0019673)3.16753632
54germinal center formation (GO:0002467)3.15936157
55negative regulation of interleukin-12 production (GO:0032695)3.14435855
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.13187208
57myeloid cell activation involved in immune response (GO:0002275)3.12027986
58regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10459989
59response to type I interferon (GO:0034340)3.07062367
60regulation of B cell differentiation (GO:0045577)3.03395771
61positive regulation of granulocyte differentiation (GO:0030854)3.03215122
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99681024
63type I interferon signaling pathway (GO:0060337)2.97427141
64cellular response to type I interferon (GO:0071357)2.97427141
65purinergic receptor signaling pathway (GO:0035587)2.97165058
66positive regulation of B cell differentiation (GO:0045579)2.97129668
67negative regulation of glycoprotein biosynthetic process (GO:0010561)2.97035627
68leukocyte degranulation (GO:0043299)2.96847660
69regulation of T cell tolerance induction (GO:0002664)2.96670960
70detection of molecule of bacterial origin (GO:0032490)2.95599971
71G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.92425524
72regulation of alpha-beta T cell proliferation (GO:0046640)2.88860031
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87493833
74detection of biotic stimulus (GO:0009595)2.86478258
75negative regulation of toll-like receptor signaling pathway (GO:0034122)2.86423941
76regulation of T cell mediated cytotoxicity (GO:0001914)2.84105955
77defense response to protozoan (GO:0042832)2.79947734
78positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78851421
79negative regulation of interleukin-8 production (GO:0032717)2.78486050
80regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78053095
81regulation of tolerance induction (GO:0002643)2.76514340
82regulation of granulocyte differentiation (GO:0030852)2.75400465
83regulation of mast cell degranulation (GO:0043304)2.74867331
84immunoglobulin mediated immune response (GO:0016064)2.74367949
85T cell homeostasis (GO:0043029)2.71944316
86neutrophil activation (GO:0042119)2.69959329
87mast cell activation (GO:0045576)2.69937990
88antigen processing and presentation via MHC class Ib (GO:0002475)2.69830704
89CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.69285488
90regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68696149
91positive regulation of interferon-alpha production (GO:0032727)2.67658471
92regulation of regulatory T cell differentiation (GO:0045589)2.65728145
93regulation of natural killer cell mediated immunity (GO:0002715)2.65267915
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.65267915
95antigen receptor-mediated signaling pathway (GO:0050851)2.65030748
96positive regulation of Rap GTPase activity (GO:0032854)2.64732235
97granulocyte activation (GO:0036230)2.64319319
98negative regulation of tumor necrosis factor production (GO:0032720)2.64312480
99response to host immune response (GO:0052572)2.63970007
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.63970007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.28144655
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.46257480
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.16893637
4MYC_22102868_ChIP-Seq_BL_Human3.12265238
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.83475104
6VDR_24763502_ChIP-Seq_THP-1_Human2.80210414
7MAF_26560356_Chip-Seq_TH1_Human2.76509367
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.70978725
9MAF_26560356_Chip-Seq_TH2_Human2.66849865
10LXR_22292898_ChIP-Seq_THP-1_Human2.61517655
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48382807
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47884031
13* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.45752688
14TCF7_22412390_ChIP-Seq_EML_Mouse2.43012764
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.42642957
16KDM2B_26808549_Chip-Seq_DND41_Human2.42071599
17UTX_26944678_Chip-Seq_JUKART_Human2.41919236
18P68_20966046_ChIP-Seq_HELA_Human2.17610963
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02118533
20SCL_19346495_ChIP-Seq_HPC-7_Human2.00562352
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.95724011
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95409739
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94668146
24RUNX1_22412390_ChIP-Seq_EML_Mouse1.92581191
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.89539700
26BCL6_27268052_Chip-Seq_Bcells_Human1.88695892
27BCOR_27268052_Chip-Seq_Bcells_Human1.84726015
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84331924
29RUNX_20019798_ChIP-Seq_JUKART_Human1.77533712
30RACK7_27058665_Chip-Seq_MCF-7_Human1.74333878
31CTCF_27219007_Chip-Seq_ERYTHROID_Human1.73134130
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71275585
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70425610
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69761457
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67385103
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66111491
37MYB_26560356_Chip-Seq_TH1_Human1.65696405
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.64704695
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61980351
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.58117921
41SMC4_20622854_ChIP-Seq_HELA_Human1.57971756
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57110164
43MYB_26560356_Chip-Seq_TH2_Human1.56636273
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54510756
45SPI1_23547873_ChIP-Seq_NB4_Human1.54002883
46E2F1_20622854_ChIP-Seq_HELA_Human1.52436963
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52342696
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51874558
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.51815643
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50600358
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.49840393
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.47817067
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45995239
54PU.1_20513432_ChIP-Seq_Bcells_Mouse1.45975234
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45258271
56PHF8_20622854_ChIP-Seq_HELA_Human1.44412427
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.43063299
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42978261
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41822645
60SPI1_23127762_ChIP-Seq_K562_Human1.41276665
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.41202225
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38616218
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.36847322
64CIITA_25753668_ChIP-Seq_RAJI_Human1.35273705
65MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35005693
66NCOR1_26117541_ChIP-Seq_K562_Human1.33292465
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31203366
68KDM2B_26808549_Chip-Seq_K562_Human1.30864763
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30601157
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30597825
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28499823
72CTCF_21964334_ChIP-Seq_BJAB-B_Human1.28494651
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25298924
74CTCF_27219007_Chip-Seq_Bcells_Human1.24671468
75RARB_24833708_ChIP-Seq_LIVER_Mouse1.23327458
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22106417
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22029517
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22000440
79CREB1_26743006_Chip-Seq_LNCaP_Human1.21493523
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20843545
81CTCF_21964334_Chip-Seq_Bcells_Human1.20179795
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18436169
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17038537
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17009631
85GATA1_19941826_ChIP-Seq_K562_Human1.15970921
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14259962
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13427651
88GATA3_27048872_Chip-Seq_THYMUS_Human1.13302588
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13270002
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12629154
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.11890814
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11114992
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10241380
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09589474
95SA1_27219007_Chip-Seq_Bcells_Human1.09391868
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09305439
97ETS1_21867929_ChIP-Seq_TH2_Mouse1.09128060
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08176645
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07827625
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07422021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity4.08122317
2MP0003436_decreased_susceptibility_to3.68738293
3MP0003303_peritoneal_inflammation3.34948018
4MP0005174_abnormal_tail_pigmentation3.21115340
5MP0003763_abnormal_thymus_physiology3.13856927
6MP0003724_increased_susceptibility_to3.09753302
7MP0001835_abnormal_antigen_presentation2.88653028
8MP0004381_abnormal_hair_follicle2.87530076
9MP0001800_abnormal_humoral_immune2.68984896
10MP0005171_absent_coat_pigmentation2.48433407
11MP0005671_abnormal_response_to2.43549870
12MP0005025_abnormal_response_to2.35192635
13MP0000685_abnormal_immune_system2.35120427
14MP0009278_abnormal_bone_marrow2.34645263
15MP0002723_abnormal_immune_serum2.31796890
16MP0005000_abnormal_immune_tolerance2.30536360
17MP0005387_immune_system_phenotype2.29974858
18MP0001790_abnormal_immune_system2.29974858
19MP0002419_abnormal_innate_immunity2.29551725
20MP0002420_abnormal_adaptive_immunity2.21621844
21MP0001819_abnormal_immune_cell2.19802013
22MP0005423_abnormal_somatic_nervous2.19695720
23MP0005409_darkened_coat_color2.17649498
24MP0002452_abnormal_antigen_presenting2.15090567
25MP0003172_abnormal_lysosome_physiology2.08958316
26MP0000015_abnormal_ear_pigmentation1.97719776
27MP0009333_abnormal_splenocyte_physiolog1.97324920
28MP0002398_abnormal_bone_marrow1.94771632
29MP0006082_CNS_inflammation1.91720880
30MP0001873_stomach_inflammation1.88092973
31MP0003136_yellow_coat_color1.86312057
32MP0002396_abnormal_hematopoietic_system1.84043366
33MP0002405_respiratory_system_inflammati1.81205988
34MP0000716_abnormal_immune_system1.79833415
35MP0004947_skin_inflammation1.73595664
36MP0010155_abnormal_intestine_physiology1.70516813
37MP0000703_abnormal_thymus_morphology1.69399974
38MP0009785_altered_susceptibility_to1.65450562
39MP0002148_abnormal_hypersensitivity_rea1.63607733
40MP0008260_abnormal_autophagy1.61781978
41MP0003300_gastrointestinal_ulcer1.59333227
42MP0002722_abnormal_immune_system1.54052770
43MP0000689_abnormal_spleen_morphology1.53001553
44MP0005076_abnormal_cell_differentiation1.52748878
45MP0002429_abnormal_blood_cell1.49598514
46MP0004130_abnormal_muscle_cell1.47038879
47MP0001533_abnormal_skeleton_physiology1.45488288
48MP0001188_hyperpigmentation1.39880232
49MP0001845_abnormal_inflammatory_respons1.38070863
50MP0003866_abnormal_defecation1.36286709
51MP0005058_abnormal_lysosome_morphology1.35989811
52MP0002933_joint_inflammation1.34950394
53MP0005083_abnormal_biliary_tract1.34557593
54MP0005464_abnormal_platelet_physiology1.25057938
55MP0005397_hematopoietic_system_phenotyp1.23275927
56MP0001545_abnormal_hematopoietic_system1.23275927
57MP0003453_abnormal_keratinocyte_physiol1.22426292
58MP0005451_abnormal_body_composition1.21555520
59MP0002132_abnormal_respiratory_system1.13107627
60MP0008469_abnormal_protein_level1.11235027
61MP0005310_abnormal_salivary_gland1.10924492
62MP0000858_altered_metastatic_potential1.09871883
63MP0003191_abnormal_cellular_cholesterol1.05124000
64MP0000465_gastrointestinal_hemorrhage0.93792186
65MP0004808_abnormal_hematopoietic_stem0.93134084
66MP0002998_abnormal_bone_remodeling0.91932237
67MP0001851_eye_inflammation0.91864679
68MP0001502_abnormal_circadian_rhythm0.89878995
69MP0003448_altered_tumor_morphology0.89311671
70MP0002019_abnormal_tumor_incidence0.87324171
71MP0003828_pulmonary_edema0.87275245
72MP0009764_decreased_sensitivity_to0.86166439
73MP0001968_abnormal_touch/_nociception0.84551035
74MP0003091_abnormal_cell_migration0.83934749
75MP0002009_preneoplasia0.82141050
76MP0003705_abnormal_hypodermis_morpholog0.80528163
77MP0001663_abnormal_digestive_system0.79574254
78MP0001765_abnormal_ion_homeostasis0.79546588
79MP0002166_altered_tumor_susceptibility0.78967296
80MP0003183_abnormal_peptide_metabolism0.78307237
81MP0003656_abnormal_erythrocyte_physiolo0.74823952
82MP0004510_myositis0.72358571
83MP0008961_abnormal_basal_metabolism0.70003508
84MP0003045_fibrosis0.69608005
85MP0003690_abnormal_glial_cell0.69583514
86MP0005584_abnormal_enzyme/coenzyme_acti0.66925482
87MP0000470_abnormal_stomach_morphology0.66856137
88MP0001756_abnormal_urination0.66584589
89MP0008874_decreased_physiological_sensi0.65186744
90MP0004185_abnormal_adipocyte_glucose0.64430739
91MP0009931_abnormal_skin_appearance0.64215554
92MP0001348_abnormal_lacrimal_gland0.64131885
93MP0004883_abnormal_blood_vessel0.63828008
94MP0002277_abnormal_respiratory_mucosa0.63762157
95MP0005166_decreased_susceptibility_to0.61416537
96MP0001958_emphysema0.61318574
97MP0009840_abnormal_foam_cell0.60769439
98MP0004043_abnormal_pH_regulation0.58285822
99MP0001853_heart_inflammation0.57093603
100MP0000490_abnormal_crypts_of0.55468819

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.89017731
2Pustule (HP:0200039)4.09542784
3Myositis (HP:0100614)4.03637801
4Gastrointestinal infarctions (HP:0005244)3.96037455
5Thin bony cortex (HP:0002753)3.92924314
6Annular pancreas (HP:0001734)3.89098706
7Recurrent bacterial skin infections (HP:0005406)3.82237188
8Recurrent fungal infections (HP:0002841)3.76766288
9Recurrent abscess formation (HP:0002722)3.75551320
10Elevated erythrocyte sedimentation rate (HP:0003565)3.64761631
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.54785085
12Recurrent cutaneous fungal infections (HP:0011370)3.47843859
13Chronic mucocutaneous candidiasis (HP:0002728)3.47843859
14Orchitis (HP:0100796)3.36117349
15Abnormality of macrophages (HP:0004311)3.25534657
16Panhypogammaglobulinemia (HP:0003139)3.22606144
17Testicular atrophy (HP:0000029)3.21871514
18Rib fusion (HP:0000902)3.16201106
19Retrobulbar optic neuritis (HP:0100654)3.15447032
20Optic neuritis (HP:0100653)3.15447032
21Hemorrhage of the eye (HP:0011885)3.15194238
22Poikiloderma (HP:0001029)3.14209816
23Stomatitis (HP:0010280)3.13086432
24Intestinal fistula (HP:0100819)3.10441322
25Hypochromic anemia (HP:0001931)3.09883918
26Meningitis (HP:0001287)3.07259905
27Abnormality of the fingertips (HP:0001211)3.00439674
28Recurrent skin infections (HP:0001581)3.00322920
29Basal cell carcinoma (HP:0002671)2.86259117
30Obstructive lung disease (HP:0006536)2.83572259
31Chronic obstructive pulmonary disease (HP:0006510)2.83572259
32Colitis (HP:0002583)2.78293406
33Mediastinal lymphadenopathy (HP:0100721)2.76238169
34Ulnar bowing (HP:0003031)2.74466753
35Increased IgE level (HP:0003212)2.73558542
36Prolonged bleeding time (HP:0003010)2.73458166
37Facial hemangioma (HP:0000329)2.69611416
38Encephalitis (HP:0002383)2.67532150
39T lymphocytopenia (HP:0005403)2.65441408
40Recurrent viral infections (HP:0004429)2.60229343
41Recurrent gram-negative bacterial infections (HP:0005420)2.60103435
42Gastrointestinal inflammation (HP:0004386)2.59931334
43Inflammation of the large intestine (HP:0002037)2.58741238
44Facial diplegia (HP:0001349)2.58378655
45Attenuation of retinal blood vessels (HP:0007843)2.51808405
46Chest pain (HP:0100749)2.50579792
47Abnormality of T cell number (HP:0011839)2.50239740
48Vasculitis (HP:0002633)2.49413417
49Rectal fistula (HP:0100590)2.47851509
50Rectovaginal fistula (HP:0000143)2.47851509
51Epistaxis (HP:0000421)2.47370727
52Congenital stationary night blindness (HP:0007642)2.41209294
53Squamous cell carcinoma (HP:0002860)2.39092707
54Anorexia (HP:0002039)2.35885838
55Abnormality of T cells (HP:0002843)2.35766025
56Vaginal fistula (HP:0004320)2.35163648
57Turricephaly (HP:0000262)2.34872190
58Granulocytopenia (HP:0001913)2.34822129
59Hemoptysis (HP:0002105)2.34164477
60Joint hemorrhage (HP:0005261)2.32528376
61Spontaneous hematomas (HP:0007420)2.31866513
62Cheilitis (HP:0100825)2.31051465
63Cellulitis (HP:0100658)2.30924179
64Papilledema (HP:0001085)2.28421910
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27713927
66Gingivitis (HP:0000230)2.24565210
67Joint stiffness (HP:0001387)2.22697888
68Increased serum ferritin (HP:0003281)2.18003099
69Dyschromatopsia (HP:0007641)2.13284430
70Akinesia (HP:0002304)2.12629061
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11990377
72Abnormality of polysaccharide metabolism (HP:0011012)2.11990377
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11990377
74Easy fatigability (HP:0003388)2.11444852
75Keratoconjunctivitis sicca (HP:0001097)2.11420704
76Anteriorly placed anus (HP:0001545)2.08774659
77Keratoconjunctivitis (HP:0001096)2.08216021
78Agammaglobulinemia (HP:0004432)2.06783983
79Mucopolysacchariduria (HP:0008155)2.04659648
80Urinary glycosaminoglycan excretion (HP:0003541)2.04659648
81Premature graying of hair (HP:0002216)2.04634212
82Pulmonary infiltrates (HP:0002113)2.03414718
83Abnormality of T cell physiology (HP:0011840)2.02469240
84Arterial thrombosis (HP:0004420)2.02029705
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00121174
86Short chin (HP:0000331)2.00033684
87Slow saccadic eye movements (HP:0000514)1.96018607
88Leukocytosis (HP:0001974)1.94134524
89Emphysema (HP:0002097)1.92518026
90Papilloma (HP:0012740)1.92103995
91Verrucae (HP:0200043)1.92103995
92Ocular albinism (HP:0001107)1.90913758
93Malnutrition (HP:0004395)1.90554906
94Abnormality of the costochondral junction (HP:0000919)1.90323836
95Nasal polyposis (HP:0100582)1.88510893
96Dysostosis multiplex (HP:0000943)1.87346710
97Abnormality of iron homeostasis (HP:0011031)1.86735195
98Obstructive sleep apnea (HP:0002870)1.86353911
99Enlarged epiphyses (HP:0010580)1.82790634
100Dislocated radial head (HP:0003083)1.81536794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.92598931
2BLK3.05893927
3RIPK43.01121726
4PRPF4B2.74108254
5MAPK152.71927005
6MAP2K32.71184002
7GRK62.67290228
8ERN12.63771820
9TRIB32.60353527
10ZAP702.34911636
11TYK22.06108166
12TXK2.04895956
13TNK22.03278706
14SIK22.02052934
15CSK1.88734910
16FES1.84781467
17IRAK41.79157206
18SIK11.77535231
19BTK1.65136287
20JAK31.53626795
21IKBKE1.53467574
22EPHB11.42215832
23MAP3K131.41926457
24TBK11.41466768
25SYK1.39529129
26MAP3K141.37841254
27MARK21.37550631
28ITK1.30828111
29CDK121.29008375
30HCK1.27701367
31SMG11.24884057
32PRKD21.24388439
33SIK31.20806610
34TESK21.19355559
35JAK11.12749243
36MAPK121.11883201
37MAP3K31.10283416
38MAP3K111.09236273
39WNK41.05976103
40LCK1.03462195
41MAP3K101.02131526
42LYN1.01809185
43FGFR40.99915479
44MAP3K70.99092395
45EEF2K0.98800043
46CDC42BPA0.98469503
47IKBKB0.97152464
48TAOK10.95870747
49PDPK10.95323280
50CDK40.93878005
51IRAK20.93164447
52MAP2K60.93115287
53ICK0.91315836
54HIPK20.91252714
55TAOK30.90361928
56MAPK110.89223402
57CAMKK10.87959001
58MAP3K10.86253266
59JAK20.82599903
60PDK10.81866453
61MARK30.80807059
62PTK60.79354443
63TLK10.78399575
64KIT0.77082673
65WNK10.75773024
66TEC0.75690295
67CSF1R0.75677780
68PKN20.70289580
69RPS6KC10.69690268
70RPS6KL10.69690268
71DYRK1B0.69574379
72KSR20.69218807
73RPS6KA60.68990918
74STK110.68552492
75FGFR30.67938524
76MAPK70.63743628
77MELK0.60109820
78PRKCQ0.58095318
79TYRO30.57006480
80MAP3K60.55155164
81CDK60.54402986
82RPS6KA20.53893448
83FGR0.53883269
84MAP2K20.53409790
85RET0.51181919
86PRKCH0.48549343
87PIM10.48503647
88IRAK10.47232554
89BMX0.45940141
90RIPK10.45782617
91PRKD10.44788371
92SGK30.43177454
93STK100.42850277
94CHUK0.41984023
95STK380.40709332
96DAPK20.38559700
97MTOR0.38431280
98FYN0.37340300
99ACVR1B0.36939859
100IRAK30.36655341

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.84355783
2Primary immunodeficiency_Homo sapiens_hsa053402.41333820
3Osteoclast differentiation_Homo sapiens_hsa043802.28407444
4B cell receptor signaling pathway_Homo sapiens_hsa046622.18070783
5Leishmaniasis_Homo sapiens_hsa051402.04573689
6Other glycan degradation_Homo sapiens_hsa005112.03948434
7T cell receptor signaling pathway_Homo sapiens_hsa046601.95441559
8Acute myeloid leukemia_Homo sapiens_hsa052211.89278460
9Graft-versus-host disease_Homo sapiens_hsa053321.87136618
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85338433
11Sulfur relay system_Homo sapiens_hsa041221.79939872
12Allograft rejection_Homo sapiens_hsa053301.76360388
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.73115813
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.72393993
15Staphylococcus aureus infection_Homo sapiens_hsa051501.68925919
16Autoimmune thyroid disease_Homo sapiens_hsa053201.65155063
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64459598
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64038700
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61278078
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59267514
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52146088
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.50742202
23Tuberculosis_Homo sapiens_hsa051521.49070283
24VEGF signaling pathway_Homo sapiens_hsa043701.47397893
25Non-small cell lung cancer_Homo sapiens_hsa052231.45886668
26Measles_Homo sapiens_hsa051621.45658043
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.37718097
28Hematopoietic cell lineage_Homo sapiens_hsa046401.35401049
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.32047213
30TNF signaling pathway_Homo sapiens_hsa046681.31972742
31Influenza A_Homo sapiens_hsa051641.30901670
32Chemokine signaling pathway_Homo sapiens_hsa040621.30880875
33Toxoplasmosis_Homo sapiens_hsa051451.28019644
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26173797
35Notch signaling pathway_Homo sapiens_hsa043301.18887199
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18603640
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18175258
38Herpes simplex infection_Homo sapiens_hsa051681.16635860
39Hepatitis C_Homo sapiens_hsa051601.15083314
40Inositol phosphate metabolism_Homo sapiens_hsa005621.13736122
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12529184
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12442373
43mTOR signaling pathway_Homo sapiens_hsa041501.12150575
44Type I diabetes mellitus_Homo sapiens_hsa049401.12121024
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12018199
46Chronic myeloid leukemia_Homo sapiens_hsa052201.10753041
47Hepatitis B_Homo sapiens_hsa051611.06918828
48Antigen processing and presentation_Homo sapiens_hsa046121.06822201
49Malaria_Homo sapiens_hsa051441.05212069
50Fructose and mannose metabolism_Homo sapiens_hsa000511.00886336
51Platelet activation_Homo sapiens_hsa046110.99400224
52Pancreatic cancer_Homo sapiens_hsa052120.99187214
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.97709832
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96004416
55Viral myocarditis_Homo sapiens_hsa054160.91719801
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.89499315
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88695126
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.86247706
59Prolactin signaling pathway_Homo sapiens_hsa049170.84668152
60Apoptosis_Homo sapiens_hsa042100.82375685
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81614385
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.81079760
63Insulin resistance_Homo sapiens_hsa049310.78764910
64FoxO signaling pathway_Homo sapiens_hsa040680.77069948
65Choline metabolism in cancer_Homo sapiens_hsa052310.76892430
66Endocytosis_Homo sapiens_hsa041440.75737049
67Endometrial cancer_Homo sapiens_hsa052130.75573704
68Dorso-ventral axis formation_Homo sapiens_hsa043200.75015105
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.73449108
70GnRH signaling pathway_Homo sapiens_hsa049120.73213316
71Renal cell carcinoma_Homo sapiens_hsa052110.72459243
72Asthma_Homo sapiens_hsa053100.70705796
73HTLV-I infection_Homo sapiens_hsa051660.70562369
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70048736
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69514355
76MAPK signaling pathway_Homo sapiens_hsa040100.68574532
77Pertussis_Homo sapiens_hsa051330.67566463
78Lysosome_Homo sapiens_hsa041420.67075474
79African trypanosomiasis_Homo sapiens_hsa051430.65819152
80Colorectal cancer_Homo sapiens_hsa052100.64664183
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.63803063
82Epstein-Barr virus infection_Homo sapiens_hsa051690.60501179
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59520369
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57023054
85ErbB signaling pathway_Homo sapiens_hsa040120.54201523
86Viral carcinogenesis_Homo sapiens_hsa052030.52452056
87Legionellosis_Homo sapiens_hsa051340.51616591
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49645607
89ABC transporters_Homo sapiens_hsa020100.47462868
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47353209
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47294722
92Bladder cancer_Homo sapiens_hsa052190.45347431
93Sphingolipid metabolism_Homo sapiens_hsa006000.45178543
94Circadian rhythm_Homo sapiens_hsa047100.45118344
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45018899
96Lysine degradation_Homo sapiens_hsa003100.42240457
97Glioma_Homo sapiens_hsa052140.40228958
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39836728
99Long-term potentiation_Homo sapiens_hsa047200.39615502
100Insulin signaling pathway_Homo sapiens_hsa049100.39461976

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