ZNF277

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)3.90144794
2indolalkylamine metabolic process (GO:0006586)3.88661372
3cellular ketone body metabolic process (GO:0046950)3.67349237
4indole-containing compound catabolic process (GO:0042436)3.64498735
5indolalkylamine catabolic process (GO:0046218)3.64498735
6tryptophan catabolic process (GO:0006569)3.64498735
7replication fork processing (GO:0031297)3.61199924
8tryptophan metabolic process (GO:0006568)3.56719135
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55451101
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.55451101
11NADH dehydrogenase complex assembly (GO:0010257)3.55451101
12RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.49154097
13ketone body metabolic process (GO:1902224)3.47882800
14kynurenine metabolic process (GO:0070189)3.36177405
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33811458
16water-soluble vitamin biosynthetic process (GO:0042364)3.30894953
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29285638
18organelle disassembly (GO:1903008)3.21891949
19protein complex biogenesis (GO:0070271)3.06673137
20neural tube formation (GO:0001841)3.06416914
21protein K6-linked ubiquitination (GO:0085020)3.02969382
22mitochondrial respiratory chain complex assembly (GO:0033108)3.01902443
23platelet dense granule organization (GO:0060155)3.01070268
24interkinetic nuclear migration (GO:0022027)2.98530997
25proteasome assembly (GO:0043248)2.96000349
26regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.95673721
27recombinational repair (GO:0000725)2.93710423
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93155133
29double-strand break repair via homologous recombination (GO:0000724)2.92897017
30termination of RNA polymerase III transcription (GO:0006386)2.92709501
31transcription elongation from RNA polymerase III promoter (GO:0006385)2.92709501
32ribonucleoprotein complex disassembly (GO:0032988)2.91880238
33histone mRNA metabolic process (GO:0008334)2.89537251
34establishment of protein localization to Golgi (GO:0072600)2.85649082
35negative regulation of systemic arterial blood pressure (GO:0003085)2.82394115
36respiratory chain complex IV assembly (GO:0008535)2.80178435
37centriole replication (GO:0007099)2.79168463
38chromatin remodeling at centromere (GO:0031055)2.78503295
39protein prenylation (GO:0018342)2.76348263
40prenylation (GO:0097354)2.76348263
41somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75247785
42somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75247785
43isotype switching (GO:0045190)2.75247785
44CENP-A containing nucleosome assembly (GO:0034080)2.74289919
45transcription elongation from RNA polymerase I promoter (GO:0006362)2.73305790
46positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70247567
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69308418
48DNA replication-dependent nucleosome assembly (GO:0006335)2.68334435
49DNA replication-dependent nucleosome organization (GO:0034723)2.68334435
50response to pheromone (GO:0019236)2.67859973
51regulation of meiosis I (GO:0060631)2.67315469
52forebrain morphogenesis (GO:0048853)2.64694992
53protein K63-linked deubiquitination (GO:0070536)2.63917254
54regulation of mitotic spindle checkpoint (GO:1903504)2.62256838
55regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62256838
56regulation of heat generation (GO:0031650)2.61026276
57positive regulation of cAMP-mediated signaling (GO:0043950)2.60689171
58negative regulation of DNA-dependent DNA replication (GO:2000104)2.59358878
59protein targeting to Golgi (GO:0000042)2.59231561
60synapsis (GO:0007129)2.59186930
61DNA deamination (GO:0045006)2.58245770
62xenobiotic catabolic process (GO:0042178)2.54700214
63limb bud formation (GO:0060174)2.52908601
64detection of light stimulus involved in visual perception (GO:0050908)2.52386174
65detection of light stimulus involved in sensory perception (GO:0050962)2.52386174
66somatic hypermutation of immunoglobulin genes (GO:0016446)2.51980412
67somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51980412
68photoreceptor cell maintenance (GO:0045494)2.51551752
69histone exchange (GO:0043486)2.48850407
70amine catabolic process (GO:0009310)2.48732930
71cellular biogenic amine catabolic process (GO:0042402)2.48732930
72monoubiquitinated protein deubiquitination (GO:0035520)2.48614152
73anterograde synaptic vesicle transport (GO:0048490)2.47964607
74adenosine metabolic process (GO:0046085)2.45907280
75DNA demethylation (GO:0080111)2.45720750
76signal peptide processing (GO:0006465)2.45426842
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.44787082
78behavioral response to ethanol (GO:0048149)2.44668888
79C4-dicarboxylate transport (GO:0015740)2.44033318
80S-adenosylmethionine metabolic process (GO:0046500)2.43967923
81microtubule anchoring (GO:0034453)2.43863688
82regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.43484488
83cilium morphogenesis (GO:0060271)2.43247241
84negative regulation of mast cell activation (GO:0033004)2.42491435
85regulation of DNA endoreduplication (GO:0032875)2.41945929
86positive regulation of heat generation (GO:0031652)2.41584004
87regulation of sarcomere organization (GO:0060297)2.41415839
88positive regulation of prostaglandin secretion (GO:0032308)2.40766996
89nerve growth factor signaling pathway (GO:0038180)2.39137674
90peptidyl-histidine modification (GO:0018202)2.37379225
91GPI anchor metabolic process (GO:0006505)2.36081727
92L-fucose catabolic process (GO:0042355)2.35867871
93fucose catabolic process (GO:0019317)2.35867871
94L-fucose metabolic process (GO:0042354)2.35867871
95protein neddylation (GO:0045116)2.35246779
96axoneme assembly (GO:0035082)2.34337020
97reciprocal DNA recombination (GO:0035825)2.33430175
98reciprocal meiotic recombination (GO:0007131)2.33430175
99polyol catabolic process (GO:0046174)2.33420274
100intra-S DNA damage checkpoint (GO:0031573)2.32648027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.04107165
2VDR_22108803_ChIP-Seq_LS180_Human2.98165198
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86022944
4TAF15_26573619_Chip-Seq_HEK293_Human2.48634469
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47776409
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.45550934
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44858820
8FUS_26573619_Chip-Seq_HEK293_Human2.41731487
9IGF1R_20145208_ChIP-Seq_DFB_Human2.39374502
10ELK1_19687146_ChIP-ChIP_HELA_Human2.32995525
11GBX2_23144817_ChIP-Seq_PC3_Human2.31161653
12ZNF274_21170338_ChIP-Seq_K562_Hela2.27933599
13EWS_26573619_Chip-Seq_HEK293_Human2.27299417
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.25712048
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.24260229
16P300_19829295_ChIP-Seq_ESCs_Human2.13287269
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11901592
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05753800
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95273627
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92313444
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88504910
22* ER_23166858_ChIP-Seq_MCF-7_Human1.88484031
23* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88232782
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81158530
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.79817208
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78715913
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67272249
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62654908
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.61436986
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58541674
31VDR_23849224_ChIP-Seq_CD4+_Human1.56550098
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56190060
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56011095
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53271145
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51837470
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48481023
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47399077
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.47128815
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46924274
40CBP_20019798_ChIP-Seq_JUKART_Human1.46462964
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46462964
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.46050733
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43223964
44NANOG_19829295_ChIP-Seq_ESCs_Human1.42303908
45SOX2_19829295_ChIP-Seq_ESCs_Human1.42303908
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40922293
47SMAD4_21799915_ChIP-Seq_A2780_Human1.39218933
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36786104
49IRF1_19129219_ChIP-ChIP_H3396_Human1.36432274
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.36346909
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36234083
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35819753
53BCAT_22108803_ChIP-Seq_LS180_Human1.35110050
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35008718
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31624679
56* STAT3_23295773_ChIP-Seq_U87_Human1.31256918
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30282244
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29570815
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.29358016
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29225415
61AR_25329375_ChIP-Seq_VCAP_Human1.28861033
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28671939
63* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27013385
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26957032
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.25558154
66* CDX2_22108803_ChIP-Seq_LS180_Human1.24289885
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22175588
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21048146
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20256861
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.19846029
71TCF4_23295773_ChIP-Seq_U87_Human1.19001428
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18981260
73TCF4_22108803_ChIP-Seq_LS180_Human1.18790601
74MYC_18940864_ChIP-ChIP_HL60_Human1.18119716
75P53_22387025_ChIP-Seq_ESCs_Mouse1.17119543
76* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17117262
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.16736587
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15529456
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.14997541
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14832014
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14381372
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13932130
83OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12856347
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12772450
85P300_18555785_Chip-Seq_ESCs_Mouse1.11629642
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11129405
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11129405
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.09147957
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08019753
90FOXP3_21729870_ChIP-Seq_TREG_Human1.07427917
91* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07400738
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.06615124
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.06313339
94TP53_22573176_ChIP-Seq_HFKS_Human1.06085019
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05476592
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05476592
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04587804
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03468780
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02073333
100* RUNX2_22187159_ChIP-Seq_PCA_Human1.01417236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.67204911
2MP0000372_irregular_coat_pigmentation3.12895783
3MP0008057_abnormal_DNA_replication2.63928631
4MP0003806_abnormal_nucleotide_metabolis2.61297724
5MP0009697_abnormal_copulation2.58943343
6MP0000569_abnormal_digit_pigmentation2.44580368
7MP0008877_abnormal_DNA_methylation2.42152538
8MP0005084_abnormal_gallbladder_morpholo2.38973720
9MP0006072_abnormal_retinal_apoptosis2.21197076
10MP0002163_abnormal_gland_morphology2.14470343
11MP0002102_abnormal_ear_morphology2.03469833
12MP0002138_abnormal_hepatobiliary_system1.88014132
13MP0005253_abnormal_eye_physiology1.87692821
14MP0002837_dystrophic_cardiac_calcinosis1.83800759
15MP0008995_early_reproductive_senescence1.82913907
16MP0005075_abnormal_melanosome_morpholog1.81416791
17MP0002139_abnormal_hepatobiliary_system1.80494316
18MP0008058_abnormal_DNA_repair1.78557264
19MP0005551_abnormal_eye_electrophysiolog1.66809625
20MP0006054_spinal_hemorrhage1.66532818
21MP0005379_endocrine/exocrine_gland_phen1.63078723
22MP0003718_maternal_effect1.61130096
23MP0001764_abnormal_homeostasis1.60891611
24MP0003890_abnormal_embryonic-extraembry1.60108503
25MP0005085_abnormal_gallbladder_physiolo1.54559983
26MP0003787_abnormal_imprinting1.54141266
27MP0008872_abnormal_physiological_respon1.53452171
28MP0003136_yellow_coat_color1.52290665
29MP0005646_abnormal_pituitary_gland1.50245164
30MP0000631_abnormal_neuroendocrine_gland1.44216569
31MP0002254_reproductive_system_inflammat1.40831671
32MP0002736_abnormal_nociception_after1.38690715
33MP0003567_abnormal_fetal_cardiomyocyte1.31579737
34MP0001529_abnormal_vocalization1.29763453
35MP0005365_abnormal_bile_salt1.29222408
36MP0006292_abnormal_olfactory_placode1.27934754
37MP0000383_abnormal_hair_follicle1.26489581
38MP0003868_abnormal_feces_composition1.25872799
39MP0009764_decreased_sensitivity_to1.25157021
40MP0005310_abnormal_salivary_gland1.24817679
41MP0002938_white_spotting1.24653300
42MP0010386_abnormal_urinary_bladder1.19467739
43MP0003252_abnormal_bile_duct1.18404723
44MP0005645_abnormal_hypothalamus_physiol1.18268093
45MP0005408_hypopigmentation1.14683705
46MP0005410_abnormal_fertilization1.14595729
47MP0010094_abnormal_chromosome_stability1.13512822
48MP0002148_abnormal_hypersensitivity_rea1.12059119
49MP0000427_abnormal_hair_cycle1.11851562
50MP0005389_reproductive_system_phenotype1.10983313
51MP0005174_abnormal_tail_pigmentation1.09720928
52MP0001919_abnormal_reproductive_system1.08858685
53MP0008875_abnormal_xenobiotic_pharmacok1.06899481
54MP0006035_abnormal_mitochondrial_morpho1.06426344
55MP0002090_abnormal_vision1.05096643
56MP0002928_abnormal_bile_duct1.04568040
57MP0003011_delayed_dark_adaptation1.04562105
58MP0004215_abnormal_myocardial_fiber1.03260167
59MP0002638_abnormal_pupillary_reflex1.02318488
60MP0001835_abnormal_antigen_presentation1.01287114
61MP0003186_abnormal_redox_activity1.01281092
62MP0001188_hyperpigmentation1.00675667
63MP0001984_abnormal_olfaction0.99938142
64MP0001324_abnormal_eye_pigmentation0.99340145
65MP0002876_abnormal_thyroid_physiology0.97982682
66MP0000647_abnormal_sebaceous_gland0.97487760
67MP0005395_other_phenotype0.95725096
68MP0001293_anophthalmia0.94650903
69MP0003646_muscle_fatigue0.94274475
70MP0001929_abnormal_gametogenesis0.93603109
71MP0002009_preneoplasia0.93456931
72MP0005220_abnormal_exocrine_pancreas0.93191766
73MP0005647_abnormal_sex_gland0.92513461
74MP0003121_genomic_imprinting0.91847341
75MP0010678_abnormal_skin_adnexa0.91548369
76MP0004142_abnormal_muscle_tone0.91008632
77MP0001968_abnormal_touch/_nociception0.90610602
78MP0002693_abnormal_pancreas_physiology0.90381093
79MP0010352_gastrointestinal_tract_polyps0.88928565
80MP0009785_altered_susceptibility_to0.88248805
81MP0006036_abnormal_mitochondrial_physio0.86825780
82MP0005332_abnormal_amino_acid0.86550386
83MP0000516_abnormal_urinary_system0.84952358
84MP0005367_renal/urinary_system_phenotyp0.84952358
85MP0002210_abnormal_sex_determination0.84883829
86MP0000653_abnormal_sex_gland0.84750245
87MP0002095_abnormal_skin_pigmentation0.84413460
88MP0002735_abnormal_chemical_nociception0.83776700
89MP0002160_abnormal_reproductive_system0.82626272
90MP0003880_abnormal_central_pattern0.81655733
91MP0005391_vision/eye_phenotype0.81546087
92MP0001986_abnormal_taste_sensitivity0.79521604
93MP0005266_abnormal_metabolism0.77747867
94MP0001501_abnormal_sleep_pattern0.77686299
95MP0006276_abnormal_autonomic_nervous0.77517452
96MP0003943_abnormal_hepatobiliary_system0.76199194
97MP0005195_abnormal_posterior_eye0.75032240
98MP0004957_abnormal_blastocyst_morpholog0.74991170
99MP0009046_muscle_twitch0.74132355
100MP0000371_diluted_coat_color0.73250549

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.33107619
2Hypothermia (HP:0002045)3.21415282
3Pancreatic cysts (HP:0001737)3.13043675
43-Methylglutaconic aciduria (HP:0003535)3.02901060
5Molar tooth sign on MRI (HP:0002419)2.83082178
6Abnormality of midbrain morphology (HP:0002418)2.83082178
7Increased hepatocellular lipid droplets (HP:0006565)2.74247444
8Lipid accumulation in hepatocytes (HP:0006561)2.72005251
9Volvulus (HP:0002580)2.69214539
10Methylmalonic acidemia (HP:0002912)2.64712459
11Medial flaring of the eyebrow (HP:0010747)2.62883315
12Increased CSF lactate (HP:0002490)2.62262658
13Acute necrotizing encephalopathy (HP:0006965)2.60899529
14Abolished electroretinogram (ERG) (HP:0000550)2.60419166
15Methylmalonic aciduria (HP:0012120)2.59246157
16Progressive macrocephaly (HP:0004481)2.58347656
17True hermaphroditism (HP:0010459)2.57282514
18Mitochondrial inheritance (HP:0001427)2.51329586
19Intestinal atresia (HP:0011100)2.49230360
20Pancreatic fibrosis (HP:0100732)2.49104912
21Acute encephalopathy (HP:0006846)2.45412164
22Type II lissencephaly (HP:0007260)2.44754615
23Colon cancer (HP:0003003)2.43863133
24Abnormality of the renal cortex (HP:0011035)2.43422929
25Nephronophthisis (HP:0000090)2.35683651
26Gonadotropin excess (HP:0000837)2.34850917
27Stenosis of the external auditory canal (HP:0000402)2.32441499
28Abnormality of methionine metabolism (HP:0010901)2.29691076
29Rhabdomyosarcoma (HP:0002859)2.29380346
30Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26547598
31Abnormality of chromosome stability (HP:0003220)2.25959380
32Hyperglycinemia (HP:0002154)2.21983751
33Renal cortical cysts (HP:0000803)2.21289826
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19052390
35Bile duct proliferation (HP:0001408)2.17032382
36Abnormal biliary tract physiology (HP:0012439)2.17032382
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.16559686
38Abnormal rod and cone electroretinograms (HP:0008323)2.15784038
39Thyroiditis (HP:0100646)2.14616945
40Cerebellar dysplasia (HP:0007033)2.13410221
41Neoplasm of the oral cavity (HP:0100649)2.13383622
42Abnormality of the renal medulla (HP:0100957)2.10011154
43Medulloblastoma (HP:0002885)2.09728627
44Stomach cancer (HP:0012126)2.06282730
45Abnormal mitochondria in muscle tissue (HP:0008316)2.05686781
46Gaze-evoked nystagmus (HP:0000640)2.04838938
47Renal Fanconi syndrome (HP:0001994)2.03949481
48Hepatocellular necrosis (HP:0001404)2.03217737
49Tubular atrophy (HP:0000092)1.99923348
50Attenuation of retinal blood vessels (HP:0007843)1.99387169
51Ketoacidosis (HP:0001993)1.99046587
52Hepatic necrosis (HP:0002605)1.98686933
53Congenital stationary night blindness (HP:0007642)1.97410785
54Increased serum lactate (HP:0002151)1.95861030
55Pancreatic islet-cell hyperplasia (HP:0004510)1.94538820
56Abnormality of serum amino acid levels (HP:0003112)1.93450683
57Abnormality of B cell number (HP:0010975)1.93198458
58Papillary thyroid carcinoma (HP:0002895)1.92839209
59Abnormality of alanine metabolism (HP:0010916)1.92692219
60Hyperalaninemia (HP:0003348)1.92692219
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92692219
62Exertional dyspnea (HP:0002875)1.91705222
63Abnormality of the labia minora (HP:0012880)1.90514951
64Genital tract atresia (HP:0001827)1.86943102
65Limb hypertonia (HP:0002509)1.86843431
66Thyroid-stimulating hormone excess (HP:0002925)1.86209939
67Thyroid carcinoma (HP:0002890)1.83721595
68Congenital primary aphakia (HP:0007707)1.82587327
69Cerebral edema (HP:0002181)1.80262615
70Neoplasm of striated muscle (HP:0009728)1.79556929
71Chronic hepatic failure (HP:0100626)1.79486245
72Sloping forehead (HP:0000340)1.79429411
73Short tibia (HP:0005736)1.78779092
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.77174782
75Abnormality of macular pigmentation (HP:0008002)1.74984966
76Gait imbalance (HP:0002141)1.73644572
77Constricted visual fields (HP:0001133)1.73599533
78Glycosuria (HP:0003076)1.73154300
79Abnormality of urine glucose concentration (HP:0011016)1.73154300
80Ketosis (HP:0001946)1.72825392
81Abnormality of renal resorption (HP:0011038)1.72084910
82Abnormal glycosylation (HP:0012345)1.71570106
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71570106
84Abnormal protein N-linked glycosylation (HP:0012347)1.71570106
85Abnormal protein glycosylation (HP:0012346)1.71570106
86Vaginal atresia (HP:0000148)1.70234472
87Abnormal hair whorl (HP:0010721)1.68452445
88Autoimmune hemolytic anemia (HP:0001890)1.66867821
89Optic disc pallor (HP:0000543)1.65496834
90Lactic acidosis (HP:0003128)1.65296632
91Congenital, generalized hypertrichosis (HP:0004540)1.63898428
92Nephrogenic diabetes insipidus (HP:0009806)1.63401165
93Decreased central vision (HP:0007663)1.62993455
94Male pseudohermaphroditism (HP:0000037)1.62148971
95Absent eyebrow (HP:0002223)1.62114523
96Bifid tongue (HP:0010297)1.61551904
97Abnormality of vitamin B metabolism (HP:0004340)1.60664149
98Median cleft lip (HP:0000161)1.60442914
99Hypoplastic iliac wings (HP:0002866)1.59913013
100B lymphocytopenia (HP:0010976)1.59889119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.01363832
2BMPR1B3.91272079
3EIF2AK33.29493447
4ACVR1B3.08432881
5ZAK2.78716772
6NUAK12.74685302
7MST42.48945574
8WNK32.45362138
9NLK2.20264921
10STK392.05101985
11TRIM282.01683108
12AKT31.94883536
13ADRBK21.93965484
14TNIK1.79695121
15MKNK21.75706868
16OXSR11.67669316
17MAP3K41.64349514
18MAP4K21.60108439
19BRSK21.56686572
20PINK11.56366595
21MKNK11.55517079
22VRK11.52619869
23PBK1.47426721
24TLK11.46273003
25ERBB31.43941644
26TAOK31.40411394
27MAPK131.38489467
28GRK11.35454196
29CSNK1G11.28492890
30MAP3K121.26513901
31CASK1.23514443
32BCR1.21901322
33WNK41.19685661
34PLK41.13368869
35STK31.12252571
36WEE11.11903429
37TEC1.04308084
38CCNB11.02292272
39EIF2AK20.99937511
40STK240.94241361
41NEK10.93033061
42TAF10.93012546
43IKBKB0.92707852
44IRAK10.91248908
45SGK20.91165906
46CSNK1G20.89033526
47STK38L0.88470723
48PLK30.88255567
49GRK70.84880998
50TGFBR10.79710969
51DYRK30.78663272
52CSNK1G30.76577656
53INSRR0.76145855
54PRKCE0.74376766
55CSNK1A1L0.73128366
56PIK3CG0.71958860
57EPHA30.71767553
58CDK30.71587555
59RPS6KA50.70672666
60PNCK0.69874281
61EIF2AK10.68991160
62BMPR20.66019100
63MAP2K70.64468662
64MUSK0.63883837
65MARK30.61044739
66TXK0.59734720
67PLK10.59215208
68MAP3K140.58232965
69MAPKAPK50.55848777
70PKN10.55316969
71DYRK20.54036679
72BUB10.51463545
73MATK0.49928947
74FER0.47463367
75STK160.46701807
76PAK30.45689182
77PLK20.44891628
78ADRBK10.44604509
79MAP2K40.44328165
80PRKCQ0.43529818
81STK40.42433699
82CHUK0.41633589
83PRKCG0.41501335
84MAP2K60.40115229
85MELK0.39255589
86TTK0.39038996
87ATM0.38914035
88NEK20.38904160
89MAPKAPK30.37944349
90IKBKE0.35107448
91PIK3CA0.34699696
92CAMKK20.34565141
93CDK190.32351659
94SGK4940.31373154
95SGK2230.31373154
96TIE10.30666908
97MAP3K50.28936267
98RPS6KB20.28859261
99PIM10.28605411
100EGFR0.28310439

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.50386698
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06919035
3Oxidative phosphorylation_Homo sapiens_hsa001902.58967195
4Propanoate metabolism_Homo sapiens_hsa006402.52072968
5RNA polymerase_Homo sapiens_hsa030202.36682703
6Basal transcription factors_Homo sapiens_hsa030222.34247729
7Butanoate metabolism_Homo sapiens_hsa006502.30164923
8Systemic lupus erythematosus_Homo sapiens_hsa053222.07250051
9Asthma_Homo sapiens_hsa053102.05021148
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00742390
11RNA degradation_Homo sapiens_hsa030181.97735248
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85980499
13Tryptophan metabolism_Homo sapiens_hsa003801.83601193
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.81202742
15Homologous recombination_Homo sapiens_hsa034401.80306685
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79741539
17Parkinsons disease_Homo sapiens_hsa050121.76933334
18Proteasome_Homo sapiens_hsa030501.74215303
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.71341244
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68932259
21Ribosome_Homo sapiens_hsa030101.64670322
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63203522
23Fanconi anemia pathway_Homo sapiens_hsa034601.54190444
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52313527
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48457145
26Regulation of autophagy_Homo sapiens_hsa041401.47049916
27Allograft rejection_Homo sapiens_hsa053301.44003626
28Non-homologous end-joining_Homo sapiens_hsa034501.42944880
29Peroxisome_Homo sapiens_hsa041461.41023623
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.35318670
31Graft-versus-host disease_Homo sapiens_hsa053321.31956904
32Caffeine metabolism_Homo sapiens_hsa002321.31686768
33Type I diabetes mellitus_Homo sapiens_hsa049401.27578260
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24004285
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22764456
36Huntingtons disease_Homo sapiens_hsa050161.20863588
37Linoleic acid metabolism_Homo sapiens_hsa005911.19047238
38Autoimmune thyroid disease_Homo sapiens_hsa053201.18776112
39Rheumatoid arthritis_Homo sapiens_hsa053231.16595026
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11915227
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10858587
42Selenocompound metabolism_Homo sapiens_hsa004501.09163116
43Phototransduction_Homo sapiens_hsa047441.08976328
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06650081
45RNA transport_Homo sapiens_hsa030131.05947703
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05911384
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05405649
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.04201903
49Ether lipid metabolism_Homo sapiens_hsa005651.03499891
50Chemical carcinogenesis_Homo sapiens_hsa052041.02349469
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00853342
52Alzheimers disease_Homo sapiens_hsa050100.99619937
53Nucleotide excision repair_Homo sapiens_hsa034200.96254528
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95378995
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93437328
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92471982
57Alcoholism_Homo sapiens_hsa050340.92272861
58One carbon pool by folate_Homo sapiens_hsa006700.88674761
59Retinol metabolism_Homo sapiens_hsa008300.88296380
60Mismatch repair_Homo sapiens_hsa034300.86236325
61Steroid biosynthesis_Homo sapiens_hsa001000.85791787
62Olfactory transduction_Homo sapiens_hsa047400.83302500
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78388864
64Purine metabolism_Homo sapiens_hsa002300.76674402
65Collecting duct acid secretion_Homo sapiens_hsa049660.75242025
66Nitrogen metabolism_Homo sapiens_hsa009100.71213498
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69238901
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68392281
69Pyrimidine metabolism_Homo sapiens_hsa002400.66868548
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64960324
71ABC transporters_Homo sapiens_hsa020100.64543788
72Legionellosis_Homo sapiens_hsa051340.64006159
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63048508
74African trypanosomiasis_Homo sapiens_hsa051430.62927164
75Fatty acid degradation_Homo sapiens_hsa000710.61928154
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.60439618
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.57829107
78Nicotine addiction_Homo sapiens_hsa050330.57684306
79Metabolic pathways_Homo sapiens_hsa011000.54423291
80Staphylococcus aureus infection_Homo sapiens_hsa051500.53416336
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52116134
82p53 signaling pathway_Homo sapiens_hsa041150.50553721
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.49895216
84beta-Alanine metabolism_Homo sapiens_hsa004100.49861540
85Arachidonic acid metabolism_Homo sapiens_hsa005900.45756277
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45070994
87Fatty acid elongation_Homo sapiens_hsa000620.44949498
88Circadian rhythm_Homo sapiens_hsa047100.43361418
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41857315
90Glutathione metabolism_Homo sapiens_hsa004800.41007228
91TGF-beta signaling pathway_Homo sapiens_hsa043500.40702302
92Sulfur metabolism_Homo sapiens_hsa009200.37893929
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37705160
94Taste transduction_Homo sapiens_hsa047420.37241884
95Fatty acid metabolism_Homo sapiens_hsa012120.35991825
96mRNA surveillance pathway_Homo sapiens_hsa030150.34864798
97Fatty acid biosynthesis_Homo sapiens_hsa000610.34213529
98Serotonergic synapse_Homo sapiens_hsa047260.33806105
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31431699
100Mineral absorption_Homo sapiens_hsa049780.27853350

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