ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	3.90144794
2	indolalkylamine metabolic process (GO:0006586)	3.88661372
3	cellular ketone body metabolic process (GO:0046950)	3.67349237
4	indole-containing compound catabolic process (GO:0042436)	3.64498735
5	indolalkylamine catabolic process (GO:0046218)	3.64498735
6	tryptophan catabolic process (GO:0006569)	3.64498735
7	replication fork processing (GO:0031297)	3.61199924
8	tryptophan metabolic process (GO:0006568)	3.56719135
9	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55451101
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55451101
11	NADH dehydrogenase complex assembly (GO:0010257)	3.55451101
12	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.49154097
13	ketone body metabolic process (GO:1902224)	3.47882800
14	kynurenine metabolic process (GO:0070189)	3.36177405
15	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.33811458
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.30894953
17	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29285638
18	organelle disassembly (GO:1903008)	3.21891949
19	protein complex biogenesis (GO:0070271)	3.06673137
20	neural tube formation (GO:0001841)	3.06416914
21	protein K6-linked ubiquitination (GO:0085020)	3.02969382
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.01902443
23	platelet dense granule organization (GO:0060155)	3.01070268
24	interkinetic nuclear migration (GO:0022027)	2.98530997
25	proteasome assembly (GO:0043248)	2.96000349
26	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.95673721
27	recombinational repair (GO:0000725)	2.93710423
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.93155133
29	double-strand break repair via homologous recombination (GO:0000724)	2.92897017
30	termination of RNA polymerase III transcription (GO:0006386)	2.92709501
31	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.92709501
32	ribonucleoprotein complex disassembly (GO:0032988)	2.91880238
33	histone mRNA metabolic process (GO:0008334)	2.89537251
34	establishment of protein localization to Golgi (GO:0072600)	2.85649082
35	negative regulation of systemic arterial blood pressure (GO:0003085)	2.82394115
36	respiratory chain complex IV assembly (GO:0008535)	2.80178435
37	centriole replication (GO:0007099)	2.79168463
38	chromatin remodeling at centromere (GO:0031055)	2.78503295
39	protein prenylation (GO:0018342)	2.76348263
40	prenylation (GO:0097354)	2.76348263
41	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.75247785
42	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.75247785
43	isotype switching (GO:0045190)	2.75247785
44	CENP-A containing nucleosome assembly (GO:0034080)	2.74289919
45	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.73305790
46	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.70247567
47	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.69308418
48	DNA replication-dependent nucleosome assembly (GO:0006335)	2.68334435
49	DNA replication-dependent nucleosome organization (GO:0034723)	2.68334435
50	response to pheromone (GO:0019236)	2.67859973
51	regulation of meiosis I (GO:0060631)	2.67315469
52	forebrain morphogenesis (GO:0048853)	2.64694992
53	protein K63-linked deubiquitination (GO:0070536)	2.63917254
54	regulation of mitotic spindle checkpoint (GO:1903504)	2.62256838
55	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.62256838
56	regulation of heat generation (GO:0031650)	2.61026276
57	positive regulation of cAMP-mediated signaling (GO:0043950)	2.60689171
58	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.59358878
59	protein targeting to Golgi (GO:0000042)	2.59231561
60	synapsis (GO:0007129)	2.59186930
61	DNA deamination (GO:0045006)	2.58245770
62	xenobiotic catabolic process (GO:0042178)	2.54700214
63	limb bud formation (GO:0060174)	2.52908601
64	detection of light stimulus involved in visual perception (GO:0050908)	2.52386174
65	detection of light stimulus involved in sensory perception (GO:0050962)	2.52386174
66	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.51980412
67	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.51980412
68	photoreceptor cell maintenance (GO:0045494)	2.51551752
69	histone exchange (GO:0043486)	2.48850407
70	amine catabolic process (GO:0009310)	2.48732930
71	cellular biogenic amine catabolic process (GO:0042402)	2.48732930
72	monoubiquitinated protein deubiquitination (GO:0035520)	2.48614152
73	anterograde synaptic vesicle transport (GO:0048490)	2.47964607
74	adenosine metabolic process (GO:0046085)	2.45907280
75	DNA demethylation (GO:0080111)	2.45720750
76	signal peptide processing (GO:0006465)	2.45426842
77	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.44787082
78	behavioral response to ethanol (GO:0048149)	2.44668888
79	C4-dicarboxylate transport (GO:0015740)	2.44033318
80	S-adenosylmethionine metabolic process (GO:0046500)	2.43967923
81	microtubule anchoring (GO:0034453)	2.43863688
82	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.43484488
83	cilium morphogenesis (GO:0060271)	2.43247241
84	negative regulation of mast cell activation (GO:0033004)	2.42491435
85	regulation of DNA endoreduplication (GO:0032875)	2.41945929
86	positive regulation of heat generation (GO:0031652)	2.41584004
87	regulation of sarcomere organization (GO:0060297)	2.41415839
88	positive regulation of prostaglandin secretion (GO:0032308)	2.40766996
89	nerve growth factor signaling pathway (GO:0038180)	2.39137674
90	peptidyl-histidine modification (GO:0018202)	2.37379225
91	GPI anchor metabolic process (GO:0006505)	2.36081727
92	L-fucose catabolic process (GO:0042355)	2.35867871
93	fucose catabolic process (GO:0019317)	2.35867871
94	L-fucose metabolic process (GO:0042354)	2.35867871
95	protein neddylation (GO:0045116)	2.35246779
96	axoneme assembly (GO:0035082)	2.34337020
97	reciprocal DNA recombination (GO:0035825)	2.33430175
98	reciprocal meiotic recombination (GO:0007131)	2.33430175
99	polyol catabolic process (GO:0046174)	2.33420274
100	intra-S DNA damage checkpoint (GO:0031573)	2.32648027

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.04107165
2	VDR_22108803_ChIP-Seq_LS180_Human	2.98165198
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.86022944
4	TAF15_26573619_Chip-Seq_HEK293_Human	2.48634469
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47776409
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.45550934
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.44858820
8	FUS_26573619_Chip-Seq_HEK293_Human	2.41731487
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39374502
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.32995525
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.31161653
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.27933599
13	EWS_26573619_Chip-Seq_HEK293_Human	2.27299417
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.25712048
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.24260229
16	P300_19829295_ChIP-Seq_ESCs_Human	2.13287269
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.11901592
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05753800
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.95273627
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92313444
21	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88504910
22	* ER_23166858_ChIP-Seq_MCF-7_Human	1.88484031
23	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.88232782
24	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.81158530
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.79817208
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78715913
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67272249
28	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.62654908
29	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.61436986
30	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58541674
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.56550098
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56190060
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56011095
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53271145
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51837470
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48481023
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.47399077
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47128815
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46924274
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.46462964
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46462964
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46050733
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.43223964
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42303908
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42303908
46	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.40922293
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39218933
48	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.36786104
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36432274
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36346909
51	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36234083
52	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.35819753
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.35110050
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35008718
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31624679
56	* STAT3_23295773_ChIP-Seq_U87_Human	1.31256918
57	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30282244
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29570815
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29358016
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29225415
61	AR_25329375_ChIP-Seq_VCAP_Human	1.28861033
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28671939
63	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27013385
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26957032
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25558154
66	* CDX2_22108803_ChIP-Seq_LS180_Human	1.24289885
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22175588
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21048146
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20256861
70	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.19846029
71	TCF4_23295773_ChIP-Seq_U87_Human	1.19001428
72	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.18981260
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.18790601
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.18119716
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.17119543
76	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17117262
77	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.16736587
78	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.15529456
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14997541
80	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.14832014
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.14381372
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.13932130
83	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.12856347
84	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12772450
85	P300_18555785_Chip-Seq_ESCs_Mouse	1.11629642
86	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11129405
87	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11129405
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09147957
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08019753
90	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07427917
91	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07400738
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06615124
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.06313339
94	TP53_22573176_ChIP-Seq_HFKS_Human	1.06085019
95	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.05476592
96	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.05476592
97	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04587804
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03468780
99	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02073333
100	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.01417236

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.67204911
2	MP0000372_irregular_coat_pigmentation	3.12895783
3	MP0008057_abnormal_DNA_replication	2.63928631
4	MP0003806_abnormal_nucleotide_metabolis	2.61297724
5	MP0009697_abnormal_copulation	2.58943343
6	MP0000569_abnormal_digit_pigmentation	2.44580368
7	MP0008877_abnormal_DNA_methylation	2.42152538
8	MP0005084_abnormal_gallbladder_morpholo	2.38973720
9	MP0006072_abnormal_retinal_apoptosis	2.21197076
10	MP0002163_abnormal_gland_morphology	2.14470343
11	MP0002102_abnormal_ear_morphology	2.03469833
12	MP0002138_abnormal_hepatobiliary_system	1.88014132
13	MP0005253_abnormal_eye_physiology	1.87692821
14	MP0002837_dystrophic_cardiac_calcinosis	1.83800759
15	MP0008995_early_reproductive_senescence	1.82913907
16	MP0005075_abnormal_melanosome_morpholog	1.81416791
17	MP0002139_abnormal_hepatobiliary_system	1.80494316
18	MP0008058_abnormal_DNA_repair	1.78557264
19	MP0005551_abnormal_eye_electrophysiolog	1.66809625
20	MP0006054_spinal_hemorrhage	1.66532818
21	MP0005379_endocrine/exocrine_gland_phen	1.63078723
22	MP0003718_maternal_effect	1.61130096
23	MP0001764_abnormal_homeostasis	1.60891611
24	MP0003890_abnormal_embryonic-extraembry	1.60108503
25	MP0005085_abnormal_gallbladder_physiolo	1.54559983
26	MP0003787_abnormal_imprinting	1.54141266
27	MP0008872_abnormal_physiological_respon	1.53452171
28	MP0003136_yellow_coat_color	1.52290665
29	MP0005646_abnormal_pituitary_gland	1.50245164
30	MP0000631_abnormal_neuroendocrine_gland	1.44216569
31	MP0002254_reproductive_system_inflammat	1.40831671
32	MP0002736_abnormal_nociception_after	1.38690715
33	MP0003567_abnormal_fetal_cardiomyocyte	1.31579737
34	MP0001529_abnormal_vocalization	1.29763453
35	MP0005365_abnormal_bile_salt	1.29222408
36	MP0006292_abnormal_olfactory_placode	1.27934754
37	MP0000383_abnormal_hair_follicle	1.26489581
38	MP0003868_abnormal_feces_composition	1.25872799
39	MP0009764_decreased_sensitivity_to	1.25157021
40	MP0005310_abnormal_salivary_gland	1.24817679
41	MP0002938_white_spotting	1.24653300
42	MP0010386_abnormal_urinary_bladder	1.19467739
43	MP0003252_abnormal_bile_duct	1.18404723
44	MP0005645_abnormal_hypothalamus_physiol	1.18268093
45	MP0005408_hypopigmentation	1.14683705
46	MP0005410_abnormal_fertilization	1.14595729
47	MP0010094_abnormal_chromosome_stability	1.13512822
48	MP0002148_abnormal_hypersensitivity_rea	1.12059119
49	MP0000427_abnormal_hair_cycle	1.11851562
50	MP0005389_reproductive_system_phenotype	1.10983313
51	MP0005174_abnormal_tail_pigmentation	1.09720928
52	MP0001919_abnormal_reproductive_system	1.08858685
53	MP0008875_abnormal_xenobiotic_pharmacok	1.06899481
54	MP0006035_abnormal_mitochondrial_morpho	1.06426344
55	MP0002090_abnormal_vision	1.05096643
56	MP0002928_abnormal_bile_duct	1.04568040
57	MP0003011_delayed_dark_adaptation	1.04562105
58	MP0004215_abnormal_myocardial_fiber	1.03260167
59	MP0002638_abnormal_pupillary_reflex	1.02318488
60	MP0001835_abnormal_antigen_presentation	1.01287114
61	MP0003186_abnormal_redox_activity	1.01281092
62	MP0001188_hyperpigmentation	1.00675667
63	MP0001984_abnormal_olfaction	0.99938142
64	MP0001324_abnormal_eye_pigmentation	0.99340145
65	MP0002876_abnormal_thyroid_physiology	0.97982682
66	MP0000647_abnormal_sebaceous_gland	0.97487760
67	MP0005395_other_phenotype	0.95725096
68	MP0001293_anophthalmia	0.94650903
69	MP0003646_muscle_fatigue	0.94274475
70	MP0001929_abnormal_gametogenesis	0.93603109
71	MP0002009_preneoplasia	0.93456931
72	MP0005220_abnormal_exocrine_pancreas	0.93191766
73	MP0005647_abnormal_sex_gland	0.92513461
74	MP0003121_genomic_imprinting	0.91847341
75	MP0010678_abnormal_skin_adnexa	0.91548369
76	MP0004142_abnormal_muscle_tone	0.91008632
77	MP0001968_abnormal_touch/_nociception	0.90610602
78	MP0002693_abnormal_pancreas_physiology	0.90381093
79	MP0010352_gastrointestinal_tract_polyps	0.88928565
80	MP0009785_altered_susceptibility_to	0.88248805
81	MP0006036_abnormal_mitochondrial_physio	0.86825780
82	MP0005332_abnormal_amino_acid	0.86550386
83	MP0000516_abnormal_urinary_system	0.84952358
84	MP0005367_renal/urinary_system_phenotyp	0.84952358
85	MP0002210_abnormal_sex_determination	0.84883829
86	MP0000653_abnormal_sex_gland	0.84750245
87	MP0002095_abnormal_skin_pigmentation	0.84413460
88	MP0002735_abnormal_chemical_nociception	0.83776700
89	MP0002160_abnormal_reproductive_system	0.82626272
90	MP0003880_abnormal_central_pattern	0.81655733
91	MP0005391_vision/eye_phenotype	0.81546087
92	MP0001986_abnormal_taste_sensitivity	0.79521604
93	MP0005266_abnormal_metabolism	0.77747867
94	MP0001501_abnormal_sleep_pattern	0.77686299
95	MP0006276_abnormal_autonomic_nervous	0.77517452
96	MP0003943_abnormal_hepatobiliary_system	0.76199194
97	MP0005195_abnormal_posterior_eye	0.75032240
98	MP0004957_abnormal_blastocyst_morpholog	0.74991170
99	MP0009046_muscle_twitch	0.74132355
100	MP0000371_diluted_coat_color	0.73250549

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.33107619
2	Hypothermia (HP:0002045)	3.21415282
3	Pancreatic cysts (HP:0001737)	3.13043675
4	3-Methylglutaconic aciduria (HP:0003535)	3.02901060
5	Molar tooth sign on MRI (HP:0002419)	2.83082178
6	Abnormality of midbrain morphology (HP:0002418)	2.83082178
7	Increased hepatocellular lipid droplets (HP:0006565)	2.74247444
8	Lipid accumulation in hepatocytes (HP:0006561)	2.72005251
9	Volvulus (HP:0002580)	2.69214539
10	Methylmalonic acidemia (HP:0002912)	2.64712459
11	Medial flaring of the eyebrow (HP:0010747)	2.62883315
12	Increased CSF lactate (HP:0002490)	2.62262658
13	Acute necrotizing encephalopathy (HP:0006965)	2.60899529
14	Abolished electroretinogram (ERG) (HP:0000550)	2.60419166
15	Methylmalonic aciduria (HP:0012120)	2.59246157
16	Progressive macrocephaly (HP:0004481)	2.58347656
17	True hermaphroditism (HP:0010459)	2.57282514
18	Mitochondrial inheritance (HP:0001427)	2.51329586
19	Intestinal atresia (HP:0011100)	2.49230360
20	Pancreatic fibrosis (HP:0100732)	2.49104912
21	Acute encephalopathy (HP:0006846)	2.45412164
22	Type II lissencephaly (HP:0007260)	2.44754615
23	Colon cancer (HP:0003003)	2.43863133
24	Abnormality of the renal cortex (HP:0011035)	2.43422929
25	Nephronophthisis (HP:0000090)	2.35683651
26	Gonadotropin excess (HP:0000837)	2.34850917
27	Stenosis of the external auditory canal (HP:0000402)	2.32441499
28	Abnormality of methionine metabolism (HP:0010901)	2.29691076
29	Rhabdomyosarcoma (HP:0002859)	2.29380346
30	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.26547598
31	Abnormality of chromosome stability (HP:0003220)	2.25959380
32	Hyperglycinemia (HP:0002154)	2.21983751
33	Renal cortical cysts (HP:0000803)	2.21289826
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.19052390
35	Bile duct proliferation (HP:0001408)	2.17032382
36	Abnormal biliary tract physiology (HP:0012439)	2.17032382
37	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16559686
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.15784038
39	Thyroiditis (HP:0100646)	2.14616945
40	Cerebellar dysplasia (HP:0007033)	2.13410221
41	Neoplasm of the oral cavity (HP:0100649)	2.13383622
42	Abnormality of the renal medulla (HP:0100957)	2.10011154
43	Medulloblastoma (HP:0002885)	2.09728627
44	Stomach cancer (HP:0012126)	2.06282730
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.05686781
46	Gaze-evoked nystagmus (HP:0000640)	2.04838938
47	Renal Fanconi syndrome (HP:0001994)	2.03949481
48	Hepatocellular necrosis (HP:0001404)	2.03217737
49	Tubular atrophy (HP:0000092)	1.99923348
50	Attenuation of retinal blood vessels (HP:0007843)	1.99387169
51	Ketoacidosis (HP:0001993)	1.99046587
52	Hepatic necrosis (HP:0002605)	1.98686933
53	Congenital stationary night blindness (HP:0007642)	1.97410785
54	Increased serum lactate (HP:0002151)	1.95861030
55	Pancreatic islet-cell hyperplasia (HP:0004510)	1.94538820
56	Abnormality of serum amino acid levels (HP:0003112)	1.93450683
57	Abnormality of B cell number (HP:0010975)	1.93198458
58	Papillary thyroid carcinoma (HP:0002895)	1.92839209
59	Abnormality of alanine metabolism (HP:0010916)	1.92692219
60	Hyperalaninemia (HP:0003348)	1.92692219
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.92692219
62	Exertional dyspnea (HP:0002875)	1.91705222
63	Abnormality of the labia minora (HP:0012880)	1.90514951
64	Genital tract atresia (HP:0001827)	1.86943102
65	Limb hypertonia (HP:0002509)	1.86843431
66	Thyroid-stimulating hormone excess (HP:0002925)	1.86209939
67	Thyroid carcinoma (HP:0002890)	1.83721595
68	Congenital primary aphakia (HP:0007707)	1.82587327
69	Cerebral edema (HP:0002181)	1.80262615
70	Neoplasm of striated muscle (HP:0009728)	1.79556929
71	Chronic hepatic failure (HP:0100626)	1.79486245
72	Sloping forehead (HP:0000340)	1.79429411
73	Short tibia (HP:0005736)	1.78779092
74	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77174782
75	Abnormality of macular pigmentation (HP:0008002)	1.74984966
76	Gait imbalance (HP:0002141)	1.73644572
77	Constricted visual fields (HP:0001133)	1.73599533
78	Glycosuria (HP:0003076)	1.73154300
79	Abnormality of urine glucose concentration (HP:0011016)	1.73154300
80	Ketosis (HP:0001946)	1.72825392
81	Abnormality of renal resorption (HP:0011038)	1.72084910
82	Abnormal glycosylation (HP:0012345)	1.71570106
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.71570106
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.71570106
85	Abnormal protein glycosylation (HP:0012346)	1.71570106
86	Vaginal atresia (HP:0000148)	1.70234472
87	Abnormal hair whorl (HP:0010721)	1.68452445
88	Autoimmune hemolytic anemia (HP:0001890)	1.66867821
89	Optic disc pallor (HP:0000543)	1.65496834
90	Lactic acidosis (HP:0003128)	1.65296632
91	Congenital, generalized hypertrichosis (HP:0004540)	1.63898428
92	Nephrogenic diabetes insipidus (HP:0009806)	1.63401165
93	Decreased central vision (HP:0007663)	1.62993455
94	Male pseudohermaphroditism (HP:0000037)	1.62148971
95	Absent eyebrow (HP:0002223)	1.62114523
96	Bifid tongue (HP:0010297)	1.61551904
97	Abnormality of vitamin B metabolism (HP:0004340)	1.60664149
98	Median cleft lip (HP:0000161)	1.60442914
99	Hypoplastic iliac wings (HP:0002866)	1.59913013
100	B lymphocytopenia (HP:0010976)	1.59889119

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.01363832
2	BMPR1B	3.91272079
3	EIF2AK3	3.29493447
4	ACVR1B	3.08432881
5	ZAK	2.78716772
6	NUAK1	2.74685302
7	MST4	2.48945574
8	WNK3	2.45362138
9	NLK	2.20264921
10	STK39	2.05101985
11	TRIM28	2.01683108
12	AKT3	1.94883536
13	ADRBK2	1.93965484
14	TNIK	1.79695121
15	MKNK2	1.75706868
16	OXSR1	1.67669316
17	MAP3K4	1.64349514
18	MAP4K2	1.60108439
19	BRSK2	1.56686572
20	PINK1	1.56366595
21	MKNK1	1.55517079
22	VRK1	1.52619869
23	PBK	1.47426721
24	TLK1	1.46273003
25	ERBB3	1.43941644
26	TAOK3	1.40411394
27	MAPK13	1.38489467
28	GRK1	1.35454196
29	CSNK1G1	1.28492890
30	MAP3K12	1.26513901
31	CASK	1.23514443
32	BCR	1.21901322
33	WNK4	1.19685661
34	PLK4	1.13368869
35	STK3	1.12252571
36	WEE1	1.11903429
37	TEC	1.04308084
38	CCNB1	1.02292272
39	EIF2AK2	0.99937511
40	STK24	0.94241361
41	NEK1	0.93033061
42	TAF1	0.93012546
43	IKBKB	0.92707852
44	IRAK1	0.91248908
45	SGK2	0.91165906
46	CSNK1G2	0.89033526
47	STK38L	0.88470723
48	PLK3	0.88255567
49	GRK7	0.84880998
50	TGFBR1	0.79710969
51	DYRK3	0.78663272
52	CSNK1G3	0.76577656
53	INSRR	0.76145855
54	PRKCE	0.74376766
55	CSNK1A1L	0.73128366
56	PIK3CG	0.71958860
57	EPHA3	0.71767553
58	CDK3	0.71587555
59	RPS6KA5	0.70672666
60	PNCK	0.69874281
61	EIF2AK1	0.68991160
62	BMPR2	0.66019100
63	MAP2K7	0.64468662
64	MUSK	0.63883837
65	MARK3	0.61044739
66	TXK	0.59734720
67	PLK1	0.59215208
68	MAP3K14	0.58232965
69	MAPKAPK5	0.55848777
70	PKN1	0.55316969
71	DYRK2	0.54036679
72	BUB1	0.51463545
73	MATK	0.49928947
74	FER	0.47463367
75	STK16	0.46701807
76	PAK3	0.45689182
77	PLK2	0.44891628
78	ADRBK1	0.44604509
79	MAP2K4	0.44328165
80	PRKCQ	0.43529818
81	STK4	0.42433699
82	CHUK	0.41633589
83	PRKCG	0.41501335
84	MAP2K6	0.40115229
85	MELK	0.39255589
86	TTK	0.39038996
87	ATM	0.38914035
88	NEK2	0.38904160
89	MAPKAPK3	0.37944349
90	IKBKE	0.35107448
91	PIK3CA	0.34699696
92	CAMKK2	0.34565141
93	CDK19	0.32351659
94	SGK494	0.31373154
95	SGK223	0.31373154
96	TIE1	0.30666908
97	MAP3K5	0.28936267
98	RPS6KB2	0.28859261
99	PIM1	0.28605411
100	EGFR	0.28310439

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.50386698
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.06919035
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58967195
4	Propanoate metabolism_Homo sapiens_hsa00640	2.52072968
5	RNA polymerase_Homo sapiens_hsa03020	2.36682703
6	Basal transcription factors_Homo sapiens_hsa03022	2.34247729
7	Butanoate metabolism_Homo sapiens_hsa00650	2.30164923
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.07250051
9	Asthma_Homo sapiens_hsa05310	2.05021148
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.00742390
11	RNA degradation_Homo sapiens_hsa03018	1.97735248
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.85980499
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.83601193
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.81202742
15	Homologous recombination_Homo sapiens_hsa03440	1.80306685
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.79741539
17	Parkinsons disease_Homo sapiens_hsa05012	1.76933334
18	Proteasome_Homo sapiens_hsa03050	1.74215303
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.71341244
20	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.68932259
21	Ribosome_Homo sapiens_hsa03010	1.64670322
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63203522
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54190444
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.52313527
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48457145
26	Regulation of autophagy_Homo sapiens_hsa04140	1.47049916
27	Allograft rejection_Homo sapiens_hsa05330	1.44003626
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.42944880
29	Peroxisome_Homo sapiens_hsa04146	1.41023623
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.35318670
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.31956904
32	Caffeine metabolism_Homo sapiens_hsa00232	1.31686768
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.27578260
34	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.24004285
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.22764456
36	Huntingtons disease_Homo sapiens_hsa05016	1.20863588
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19047238
38	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.18776112
39	Rheumatoid arthritis_Homo sapiens_hsa05323	1.16595026
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11915227
41	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.10858587
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.09163116
43	Phototransduction_Homo sapiens_hsa04744	1.08976328
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06650081
45	RNA transport_Homo sapiens_hsa03013	1.05947703
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.05911384
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.05405649
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04201903
49	Ether lipid metabolism_Homo sapiens_hsa00565	1.03499891
50	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02349469
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00853342
52	Alzheimers disease_Homo sapiens_hsa05010	0.99619937
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.96254528
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95378995
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.93437328
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.92471982
57	Alcoholism_Homo sapiens_hsa05034	0.92272861
58	One carbon pool by folate_Homo sapiens_hsa00670	0.88674761
59	Retinol metabolism_Homo sapiens_hsa00830	0.88296380
60	Mismatch repair_Homo sapiens_hsa03430	0.86236325
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.85791787
62	Olfactory transduction_Homo sapiens_hsa04740	0.83302500
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78388864
64	Purine metabolism_Homo sapiens_hsa00230	0.76674402
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75242025
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.71213498
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69238901
68	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.68392281
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66868548
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.64960324
71	ABC transporters_Homo sapiens_hsa02010	0.64543788
72	Legionellosis_Homo sapiens_hsa05134	0.64006159
73	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63048508
74	African trypanosomiasis_Homo sapiens_hsa05143	0.62927164
75	Fatty acid degradation_Homo sapiens_hsa00071	0.61928154
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.60439618
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57829107
78	Nicotine addiction_Homo sapiens_hsa05033	0.57684306
79	Metabolic pathways_Homo sapiens_hsa01100	0.54423291
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53416336
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52116134
82	p53 signaling pathway_Homo sapiens_hsa04115	0.50553721
83	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.49895216
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49861540
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45756277
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45070994
87	Fatty acid elongation_Homo sapiens_hsa00062	0.44949498
88	Circadian rhythm_Homo sapiens_hsa04710	0.43361418
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41857315
90	Glutathione metabolism_Homo sapiens_hsa00480	0.41007228
91	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40702302
92	Sulfur metabolism_Homo sapiens_hsa00920	0.37893929
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37705160
94	Taste transduction_Homo sapiens_hsa04742	0.37241884
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.35991825
96	mRNA surveillance pathway_Homo sapiens_hsa03015	0.34864798
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.34213529
98	Serotonergic synapse_Homo sapiens_hsa04726	0.33806105
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31431699
100	Mineral absorption_Homo sapiens_hsa04978	0.27853350

ZNF277

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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