ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.94600569
2	protein K11-linked deubiquitination (GO:0035871)	4.55881666
3	response to pheromone (GO:0019236)	4.33886611
4	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.88551357
5	L-fucose catabolic process (GO:0042355)	3.59990259
6	fucose catabolic process (GO:0019317)	3.59990259
7	L-fucose metabolic process (GO:0042354)	3.59990259
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.46685288
9	protein prenylation (GO:0018342)	3.38033975
10	prenylation (GO:0097354)	3.38033975
11	behavioral response to nicotine (GO:0035095)	3.37465326
12	replication fork processing (GO:0031297)	3.34951103
13	neural tube formation (GO:0001841)	3.32814420
14	DNA catabolic process, exonucleolytic (GO:0000738)	3.32584232
15	recombinational repair (GO:0000725)	3.25728415
16	tryptophan catabolic process (GO:0006569)	3.22978287
17	indole-containing compound catabolic process (GO:0042436)	3.22978287
18	indolalkylamine catabolic process (GO:0046218)	3.22978287
19	double-strand break repair via homologous recombination (GO:0000724)	3.22841919
20	platelet dense granule organization (GO:0060155)	3.19889625
21	protein-cofactor linkage (GO:0018065)	3.18779491
22	regulation of centriole replication (GO:0046599)	3.18654333
23	signal peptide processing (GO:0006465)	3.17888858
24	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.07973109
25	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.07973109
26	regulation of translation, ncRNA-mediated (GO:0045974)	3.07973109
27	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.02087945
28	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.00873876
29	inositol phosphate catabolic process (GO:0071545)	3.00246947
30	adaptation of signaling pathway (GO:0023058)	2.99792279
31	DNA deamination (GO:0045006)	2.98861704
32	positive regulation of T cell cytokine production (GO:0002726)	2.98731440
33	synapsis (GO:0007129)	2.95929070
34	respiratory chain complex IV assembly (GO:0008535)	2.92276204
35	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90561832
36	centriole replication (GO:0007099)	2.89701164
37	cullin deneddylation (GO:0010388)	2.87314629
38	kynurenine metabolic process (GO:0070189)	2.84617397
39	prostate gland growth (GO:0060736)	2.84482710
40	polyol catabolic process (GO:0046174)	2.83121450
41	DNA demethylation (GO:0080111)	2.82246374
42	protein K6-linked ubiquitination (GO:0085020)	2.81230098
43	tryptophan metabolic process (GO:0006568)	2.79273498
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.79000538
45	proteasome assembly (GO:0043248)	2.76157372
46	histone H2A acetylation (GO:0043968)	2.75527891
47	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.75068860
48	isotype switching (GO:0045190)	2.75068860
49	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.75068860
50	protein deneddylation (GO:0000338)	2.74140554
51	GPI anchor metabolic process (GO:0006505)	2.73440177
52	negative regulation of execution phase of apoptosis (GO:1900118)	2.73425636
53	regulation of hexokinase activity (GO:1903299)	2.73347856
54	regulation of glucokinase activity (GO:0033131)	2.73347856
55	DNA replication-dependent nucleosome assembly (GO:0006335)	2.72134179
56	DNA replication-dependent nucleosome organization (GO:0034723)	2.72134179
57	chromatin remodeling at centromere (GO:0031055)	2.71906760
58	piRNA metabolic process (GO:0034587)	2.71744071
59	protein complex biogenesis (GO:0070271)	2.69871073
60	keratinocyte development (GO:0003334)	2.69221225
61	indolalkylamine metabolic process (GO:0006586)	2.68606005
62	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.68128693
63	inositol phosphate dephosphorylation (GO:0046855)	2.68128693
64	nucleotide transmembrane transport (GO:1901679)	2.67790944
65	histone mRNA catabolic process (GO:0071044)	2.65808883
66	single strand break repair (GO:0000012)	2.63539918
67	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.60679271
68	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.60679271
69	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.60679271
70	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.60064706
71	regulation of meiosis I (GO:0060631)	2.59992581
72	CENP-A containing nucleosome assembly (GO:0034080)	2.59666046
73	cilium morphogenesis (GO:0060271)	2.59022427
74	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.58637260
75	response to X-ray (GO:0010165)	2.57464404
76	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.57279770
77	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.56864750
78	NADH dehydrogenase complex assembly (GO:0010257)	2.56864750
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.56864750
80	epithelial cilium movement (GO:0003351)	2.56664849
81	cytochrome complex assembly (GO:0017004)	2.56639761
82	magnesium ion transport (GO:0015693)	2.55854708
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.55413783
84	branched-chain amino acid catabolic process (GO:0009083)	2.54495032
85	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.53695539
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.51981187
87	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.51981187
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50304245
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50304245
90	estrogen biosynthetic process (GO:0006703)	2.50107906
91	rRNA catabolic process (GO:0016075)	2.49927744
92	kidney morphogenesis (GO:0060993)	2.49890164
93	mitochondrial respiratory chain complex assembly (GO:0033108)	2.48448319
94	protein neddylation (GO:0045116)	2.47236617
95	reciprocal meiotic recombination (GO:0007131)	2.45517689
96	reciprocal DNA recombination (GO:0035825)	2.45517689
97	reflex (GO:0060004)	2.43766624
98	histone exchange (GO:0043486)	2.43718458
99	postreplication repair (GO:0006301)	2.43221957
100	adenosine metabolic process (GO:0046085)	2.42778837

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78807296
2	VDR_22108803_ChIP-Seq_LS180_Human	2.97781340
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.92073929
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.80505002
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.58681279
6	FUS_26573619_Chip-Seq_HEK293_Human	2.49541836
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.49308792
8	EWS_26573619_Chip-Seq_HEK293_Human	2.45693209
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37832352
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.37298692
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.36688705
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33575851
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29038553
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.24824341
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.22020965
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.21544441
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.17787654
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14417115
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09171882
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09168127
21	P300_19829295_ChIP-Seq_ESCs_Human	2.07904127
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.04661770
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01786009
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.86218299
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85187946
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.80895514
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79993264
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.77770798
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.74074905
30	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63557721
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59273624
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.58940376
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56983257
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.55423691
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.55262053
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50110416
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.48559130
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.45813881
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.45251660
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45183469
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.45183469
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43445467
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43027000
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40475949
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40340283
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38255213
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38095232
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37252926
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37135311
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.34793237
51	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.33961070
52	STAT3_23295773_ChIP-Seq_U87_Human	1.32916086
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.32663616
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31823579
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31494610
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31369949
57	AR_25329375_ChIP-Seq_VCAP_Human	1.30579641
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.28648300
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.28537187
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28474988
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27183101
62	FOXP3_21729870_ChIP-Seq_TREG_Human	1.24042677
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24011415
64	TCF4_23295773_ChIP-Seq_U87_Human	1.23495000
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23458629
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23358704
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23358704
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22536469
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22377760
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.22280131
71	CDX2_22108803_ChIP-Seq_LS180_Human	1.21711378
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21593865
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19017032
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19017032
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18999925
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16833851
77	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16817810
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16484468
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16318241
80	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.15698499
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13399621
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12904618
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12660239
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12062687
85	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09487431
86	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.09074270
87	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08521241
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.07796074
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07556862
90	P300_18555785_Chip-Seq_ESCs_Mouse	1.06760941
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06613348
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06155415
93	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06020100
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.05640717
95	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05284157
96	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.04051476
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02262900
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.01839271
99	AR_20517297_ChIP-Seq_VCAP_Human	1.01779335
100	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01701445

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.00989529
2	MP0008058_abnormal_DNA_repair	2.70612323
3	MP0003890_abnormal_embryonic-extraembry	2.57655935
4	MP0002102_abnormal_ear_morphology	2.50667370
5	MP0010094_abnormal_chromosome_stability	2.39183860
6	MP0005367_renal/urinary_system_phenotyp	2.36017241
7	MP0000516_abnormal_urinary_system	2.36017241
8	MP0003787_abnormal_imprinting	2.26371017
9	MP0008057_abnormal_DNA_replication	2.16142654
10	MP0003195_calcinosis	2.14887588
11	MP0000427_abnormal_hair_cycle	2.00753576
12	MP0003121_genomic_imprinting	1.99959960
13	MP0005551_abnormal_eye_electrophysiolog	1.91706280
14	MP0003718_maternal_effect	1.86185486
15	MP0000372_irregular_coat_pigmentation	1.85572179
16	MP0003011_delayed_dark_adaptation	1.84571564
17	MP0006072_abnormal_retinal_apoptosis	1.81425693
18	MP0002876_abnormal_thyroid_physiology	1.80895589
19	MP0002938_white_spotting	1.78989094
20	MP0005253_abnormal_eye_physiology	1.75381371
21	MP0004147_increased_porphyrin_level	1.73498972
22	MP0005645_abnormal_hypothalamus_physiol	1.73216363
23	MP0000569_abnormal_digit_pigmentation	1.72439619
24	MP0003786_premature_aging	1.69819784
25	MP0002736_abnormal_nociception_after	1.68903227
26	MP0002638_abnormal_pupillary_reflex	1.67921051
27	MP0001986_abnormal_taste_sensitivity	1.63736370
28	MP0008995_early_reproductive_senescence	1.61589663
29	MP0008872_abnormal_physiological_respon	1.61305860
30	MP0001968_abnormal_touch/_nociception	1.61112994
31	MP0003937_abnormal_limbs/digits/tail_de	1.60792977
32	MP0005084_abnormal_gallbladder_morpholo	1.53677444
33	MP0003693_abnormal_embryo_hatching	1.51596657
34	MP0002837_dystrophic_cardiac_calcinosis	1.45768516
35	MP0001984_abnormal_olfaction	1.39464628
36	MP0009697_abnormal_copulation	1.34931098
37	MP0000383_abnormal_hair_follicle	1.33633677
38	MP0003122_maternal_imprinting	1.32814618
39	MP0001529_abnormal_vocalization	1.32001784
40	MP0003136_yellow_coat_color	1.30515142
41	MP0000647_abnormal_sebaceous_gland	1.28413976
42	MP0005187_abnormal_penis_morphology	1.26415376
43	MP0006292_abnormal_olfactory_placode	1.26104620
44	MP0008775_abnormal_heart_ventricle	1.24030443
45	MP0000538_abnormal_urinary_bladder	1.23634171
46	MP0004133_heterotaxia	1.23619784
47	MP0010678_abnormal_skin_adnexa	1.20733228
48	MP0005389_reproductive_system_phenotype	1.18917513
49	MP0005075_abnormal_melanosome_morpholog	1.16887274
50	MP0008875_abnormal_xenobiotic_pharmacok	1.16409379
51	MP0001293_anophthalmia	1.15642812
52	MP0002254_reproductive_system_inflammat	1.14591697
53	MP0002751_abnormal_autonomic_nervous	1.13793590
54	MP0010386_abnormal_urinary_bladder	1.13713742
55	MP0006054_spinal_hemorrhage	1.12394798
56	MP0006035_abnormal_mitochondrial_morpho	1.12387471
57	MP0002160_abnormal_reproductive_system	1.10277049
58	MP0001919_abnormal_reproductive_system	1.10085090
59	MP0002163_abnormal_gland_morphology	1.06710991
60	MP0001929_abnormal_gametogenesis	1.05520562
61	MP0000631_abnormal_neuroendocrine_gland	1.04098753
62	MP0009046_muscle_twitch	1.03494408
63	MP0002928_abnormal_bile_duct	1.02039278
64	MP0001119_abnormal_female_reproductive	1.01008245
65	MP0002006_tumorigenesis	0.99681715
66	MP0005174_abnormal_tail_pigmentation	0.98923923
67	MP0002234_abnormal_pharynx_morphology	0.97951635
68	MP0000613_abnormal_salivary_gland	0.96967149
69	MP0005410_abnormal_fertilization	0.96827001
70	MP0002210_abnormal_sex_determination	0.96319349
71	MP0003119_abnormal_digestive_system	0.95671304
72	MP0004215_abnormal_myocardial_fiber	0.95534798
73	MP0000653_abnormal_sex_gland	0.94931389
74	MP0005379_endocrine/exocrine_gland_phen	0.94799523
75	MP0003252_abnormal_bile_duct	0.94648087
76	MP0003646_muscle_fatigue	0.92541468
77	MP0005386_behavior/neurological_phenoty	0.92047707
78	MP0004924_abnormal_behavior	0.92047707
79	MP0002095_abnormal_skin_pigmentation	0.90983318
80	MP0003698_abnormal_male_reproductive	0.90477244
81	MP0001145_abnormal_male_reproductive	0.89698439
82	MP0006276_abnormal_autonomic_nervous	0.88482347
83	MP0005646_abnormal_pituitary_gland	0.86550636
84	MP0005310_abnormal_salivary_gland	0.85861084
85	MP0002090_abnormal_vision	0.85533468
86	MP0004957_abnormal_blastocyst_morpholog	0.83911135
87	MP0004142_abnormal_muscle_tone	0.82810507
88	MP0001485_abnormal_pinna_reflex	0.80728281
89	MP0005085_abnormal_gallbladder_physiolo	0.77789879
90	MP0009780_abnormal_chondrocyte_physiolo	0.77655826
91	MP0005647_abnormal_sex_gland	0.76843788
92	MP0001324_abnormal_eye_pigmentation	0.76346267
93	MP0008007_abnormal_cellular_replicative	0.75304107
94	MP0000015_abnormal_ear_pigmentation	0.74209127
95	MP0005195_abnormal_posterior_eye	0.74026922
96	MP0005220_abnormal_exocrine_pancreas	0.73755038
97	MP0009745_abnormal_behavioral_response	0.73381302
98	MP0003567_abnormal_fetal_cardiomyocyte	0.72346425
99	MP0002693_abnormal_pancreas_physiology	0.71090391
100	MP0004885_abnormal_endolymph	0.70537275

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.72099115
2	Abnormality of midbrain morphology (HP:0002418)	3.27361293
3	Molar tooth sign on MRI (HP:0002419)	3.27361293
4	Pancreatic fibrosis (HP:0100732)	3.25265634
5	True hermaphroditism (HP:0010459)	3.22124114
6	Congenital stationary night blindness (HP:0007642)	3.10574949
7	Abnormality of the renal cortex (HP:0011035)	3.02497506
8	Intestinal atresia (HP:0011100)	3.01134010
9	Chronic hepatic failure (HP:0100626)	2.94527012
10	Progressive inability to walk (HP:0002505)	2.94095905
11	Abnormality of chromosome stability (HP:0003220)	2.88645976
12	Renal cortical cysts (HP:0000803)	2.77677274
13	Chromsome breakage (HP:0040012)	2.73922825
14	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.72659899
15	Nephronophthisis (HP:0000090)	2.71372697
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.71353575
17	Abnormality of the labia minora (HP:0012880)	2.64809307
18	Hyperventilation (HP:0002883)	2.60079505
19	Thyroiditis (HP:0100646)	2.54098263
20	Colon cancer (HP:0003003)	2.49935736
21	Medial flaring of the eyebrow (HP:0010747)	2.49096228
22	Hypoproteinemia (HP:0003075)	2.48932597
23	Type II lissencephaly (HP:0007260)	2.46631885
24	Meckel diverticulum (HP:0002245)	2.45483561
25	Abnormality of the renal medulla (HP:0100957)	2.44808434
26	Tubular atrophy (HP:0000092)	2.44266826
27	Abnormality of the ileum (HP:0001549)	2.42941478
28	Neoplasm of the adrenal cortex (HP:0100641)	2.34835937
29	Fair hair (HP:0002286)	2.27919163
30	Inability to walk (HP:0002540)	2.27884333
31	3-Methylglutaconic aciduria (HP:0003535)	2.25146126
32	Cerebellar dysplasia (HP:0007033)	2.23979559
33	Abolished electroretinogram (ERG) (HP:0000550)	2.18171726
34	Hypothermia (HP:0002045)	2.17835582
35	Abnormality of the preputium (HP:0100587)	2.17175062
36	Gaze-evoked nystagmus (HP:0000640)	2.17144475
37	Methylmalonic acidemia (HP:0002912)	2.14978104
38	Attenuation of retinal blood vessels (HP:0007843)	2.14715942
39	Volvulus (HP:0002580)	2.11127969
40	Clubbing of toes (HP:0100760)	2.10756021
41	Abnormality of the pons (HP:0007361)	2.03831940
42	Pendular nystagmus (HP:0012043)	2.02803502
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.01196235
44	Hyperalaninemia (HP:0003348)	2.00133965
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.00133965
46	Abnormality of alanine metabolism (HP:0010916)	2.00133965
47	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00057870
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.99695480
49	Optic nerve hypoplasia (HP:0000609)	1.99623753
50	Sloping forehead (HP:0000340)	1.99416439
51	Small hand (HP:0200055)	1.96853934
52	Hypoplasia of the pons (HP:0012110)	1.91357187
53	Abnormality of the duodenum (HP:0002246)	1.91326498
54	Male pseudohermaphroditism (HP:0000037)	1.89839916
55	Septate vagina (HP:0001153)	1.87573539
56	Genital tract atresia (HP:0001827)	1.85879068
57	Cystic liver disease (HP:0006706)	1.85307600
58	Breast carcinoma (HP:0003002)	1.85112760
59	Postaxial foot polydactyly (HP:0001830)	1.84691004
60	Neoplasm of the adrenal gland (HP:0100631)	1.84587824
61	Congenital primary aphakia (HP:0007707)	1.83803238
62	Broad-based gait (HP:0002136)	1.83332600
63	Increased CSF lactate (HP:0002490)	1.83008444
64	Stomach cancer (HP:0012126)	1.82933723
65	Hypoplasia of the fovea (HP:0007750)	1.82692504
66	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82692504
67	Lipid accumulation in hepatocytes (HP:0006561)	1.82502616
68	Abnormal biliary tract physiology (HP:0012439)	1.82046585
69	Bile duct proliferation (HP:0001408)	1.82046585
70	Patellar aplasia (HP:0006443)	1.81497873
71	Duodenal stenosis (HP:0100867)	1.79958974
72	Small intestinal stenosis (HP:0012848)	1.79958974
73	Postaxial hand polydactyly (HP:0001162)	1.79556696
74	Supernumerary spleens (HP:0009799)	1.78781760
75	Vaginal atresia (HP:0000148)	1.78203653
76	Gait imbalance (HP:0002141)	1.76692499
77	Nephrogenic diabetes insipidus (HP:0009806)	1.75606558
78	Lissencephaly (HP:0001339)	1.74945897
79	Furrowed tongue (HP:0000221)	1.74059239
80	Abnormality of macular pigmentation (HP:0008002)	1.73466487
81	Abnormal drinking behavior (HP:0030082)	1.72446128
82	Polydipsia (HP:0001959)	1.72446128
83	Congenital hepatic fibrosis (HP:0002612)	1.72354164
84	Sclerocornea (HP:0000647)	1.72298775
85	Increased serum lactate (HP:0002151)	1.69653132
86	Aplasia/Hypoplasia of the patella (HP:0006498)	1.69156906
87	Astigmatism (HP:0000483)	1.68674220
88	Dandy-Walker malformation (HP:0001305)	1.68639277
89	Abnormality of the fovea (HP:0000493)	1.68606015
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.67922328
91	Chorioretinal atrophy (HP:0000533)	1.65713968
92	Anencephaly (HP:0002323)	1.65607280
93	Abnormality of vitamin B metabolism (HP:0004340)	1.65057530
94	Short tibia (HP:0005736)	1.64375948
95	Increased hepatocellular lipid droplets (HP:0006565)	1.64101939
96	Absent speech (HP:0001344)	1.63159427
97	Protruding tongue (HP:0010808)	1.62568571
98	Hepatocellular necrosis (HP:0001404)	1.62474138
99	Generalized hypopigmentation of hair (HP:0011358)	1.61082908
100	Methylmalonic aciduria (HP:0012120)	1.60714291

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.40379311
2	NUAK1	3.38549290
3	ZAK	2.98355005
4	MST4	2.79260666
5	WNK3	2.71417459
6	TRIM28	2.54824102
7	BMPR1B	2.49324350
8	EIF2AK3	2.37904432
9	ACVR1B	2.28805603
10	PLK4	2.09656340
11	MAP4K2	2.05196638
12	TNIK	2.01307397
13	BRSK2	1.97792215
14	TAF1	1.89435686
15	ADRBK2	1.80840235
16	PLK3	1.79819108
17	MKNK2	1.79602586
18	PINK1	1.65788181
19	CASK	1.58639352
20	TLK1	1.53291785
21	VRK1	1.48229806
22	BCR	1.47923959
23	GRK1	1.47458082
24	SRPK1	1.46254670
25	WEE1	1.42032596
26	MAP3K12	1.39243117
27	WNK4	1.37010630
28	FGFR2	1.35994606
29	STK39	1.35161723
30	PLK2	1.29404414
31	MAPK13	1.27691683
32	MKNK1	1.24321811
33	MAP3K4	1.23008230
34	TSSK6	1.22851632
35	ERBB3	1.16761019
36	STK38L	1.15880467
37	OXSR1	1.11865440
38	FER	1.07577181
39	NEK1	1.06650374
40	EIF2AK1	1.04632213
41	AKT3	1.04548816
42	TTK	1.03211568
43	CSNK1G1	0.98123104
44	PAK3	0.97191141
45	TXK	0.96693749
46	TAOK3	0.95422248
47	PRKCE	0.95079315
48	NLK	0.94030645
49	INSRR	0.93737705
50	VRK2	0.91864448
51	PBK	0.91093879
52	STK3	0.86118148
53	PLK1	0.84563725
54	CSNK1G2	0.82816559
55	NEK9	0.82050745
56	CSNK1G3	0.80263982
57	TGFBR1	0.77065418
58	DYRK2	0.76553172
59	PNCK	0.71599612
60	YES1	0.70550938
61	IRAK1	0.70547054
62	EIF2AK2	0.69762473
63	CSNK1A1L	0.69285891
64	TIE1	0.64127256
65	CDK3	0.63384607
66	ATR	0.62163235
67	LATS1	0.60523434
68	CAMKK2	0.59792294
69	MAP2K7	0.58648190
70	EPHA3	0.56007331
71	ATM	0.54947000
72	BUB1	0.51649820
73	PRKCQ	0.48200364
74	CHEK2	0.47682546
75	CDC7	0.47568403
76	PIK3CA	0.46269996
77	PRKCG	0.46164996
78	ERBB4	0.40543523
79	TEC	0.40514398
80	MAP2K6	0.38738578
81	ADRBK1	0.38412914
82	CLK1	0.34975829
83	PDK2	0.33458749
84	PRKCI	0.32756373
85	CSNK1A1	0.31782289
86	NME1	0.31425695
87	DAPK2	0.29050920
88	SGK2	0.27945490
89	CSNK1D	0.27917889
90	PRKAA2	0.27604810
91	STK24	0.27416559
92	ABL1	0.26786598
93	RPS6KA5	0.26170896
94	AURKB	0.26163793
95	BRSK1	0.24253768
96	MUSK	0.23709734
97	PHKG1	0.22028525
98	PHKG2	0.22028525
99	CSNK2A1	0.22014135
100	IGF1R	0.21964924

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.23578650
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.87936487
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.76031400
4	Homologous recombination_Homo sapiens_hsa03440	2.70783053
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.61866482
6	Basal transcription factors_Homo sapiens_hsa03022	2.57966839
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.48067988
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.47798968
9	Propanoate metabolism_Homo sapiens_hsa00640	2.25988291
10	Proteasome_Homo sapiens_hsa03050	2.17204339
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.12348754
12	Caffeine metabolism_Homo sapiens_hsa00232	2.12182209
13	Phototransduction_Homo sapiens_hsa04744	2.00975365
14	Butanoate metabolism_Homo sapiens_hsa00650	2.00363731
15	RNA polymerase_Homo sapiens_hsa03020	1.99216178
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94071328
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.93420511
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91192292
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.88109580
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.86935701
21	One carbon pool by folate_Homo sapiens_hsa00670	1.83744411
22	RNA degradation_Homo sapiens_hsa03018	1.79226634
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.71282251
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59797988
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.58193582
26	Fatty acid elongation_Homo sapiens_hsa00062	1.57615277
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55461766
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.54256581
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.50833457
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.45233528
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.38395374
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.38147864
33	Mismatch repair_Homo sapiens_hsa03430	1.37960195
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.27963112
35	RNA transport_Homo sapiens_hsa03013	1.27738275
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.25572544
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.06781634
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04895110
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03655110
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.02962250
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01868537
42	Peroxisome_Homo sapiens_hsa04146	1.00551513
43	Circadian rhythm_Homo sapiens_hsa04710	0.99238125
44	Fatty acid metabolism_Homo sapiens_hsa01212	0.99134598
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.96168649
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96090359
47	Taste transduction_Homo sapiens_hsa04742	0.94695980
48	Regulation of autophagy_Homo sapiens_hsa04140	0.94664452
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93253557
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90608013
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89841734
52	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88475134
53	Parkinsons disease_Homo sapiens_hsa05012	0.84946690
54	Glutathione metabolism_Homo sapiens_hsa00480	0.81209936
55	p53 signaling pathway_Homo sapiens_hsa04115	0.79918249
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79280420
57	Purine metabolism_Homo sapiens_hsa00230	0.77303255
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76976079
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76870689
60	Nicotine addiction_Homo sapiens_hsa05033	0.76556073
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76290612
62	Olfactory transduction_Homo sapiens_hsa04740	0.74709117
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.74272996
64	Sulfur metabolism_Homo sapiens_hsa00920	0.69687326
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67874706
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66787031
67	Retinol metabolism_Homo sapiens_hsa00830	0.66346425
68	Metabolic pathways_Homo sapiens_hsa01100	0.63399516
69	Base excision repair_Homo sapiens_hsa03410	0.63270924
70	ABC transporters_Homo sapiens_hsa02010	0.62282719
71	Huntingtons disease_Homo sapiens_hsa05016	0.62222560
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61813312
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57044722
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.55796440
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55442589
76	Fatty acid degradation_Homo sapiens_hsa00071	0.51931536
77	DNA replication_Homo sapiens_hsa03030	0.51667874
78	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48913110
79	Folate biosynthesis_Homo sapiens_hsa00790	0.48600753
80	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.47738480
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47384090
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45893959
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45707093
84	Mineral absorption_Homo sapiens_hsa04978	0.45446763
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.45023282
86	Cell cycle_Homo sapiens_hsa04110	0.44417064
87	Alzheimers disease_Homo sapiens_hsa05010	0.41459398
88	Type I diabetes mellitus_Homo sapiens_hsa04940	0.41214018
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40956488
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40482529
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40262942
92	Oocyte meiosis_Homo sapiens_hsa04114	0.39129845
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.37193255
94	Primary immunodeficiency_Homo sapiens_hsa05340	0.36072356
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35044994
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32639385
97	Spliceosome_Homo sapiens_hsa03040	0.32164289
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31818782
99	Serotonergic synapse_Homo sapiens_hsa04726	0.31055140
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.27242362

ZNF28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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