ZNF280B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.18649725
2piRNA metabolic process (GO:0034587)4.72663766
3regulation of meiosis I (GO:0060631)4.35267324
4DNA methylation involved in gamete generation (GO:0043046)3.97413584
5male meiosis I (GO:0007141)3.89858103
6DNA double-strand break processing (GO:0000729)3.88370324
7water-soluble vitamin biosynthetic process (GO:0042364)3.71776136
8negative regulation of DNA-dependent DNA replication (GO:2000104)3.54732542
9male meiosis (GO:0007140)3.50548623
10resolution of meiotic recombination intermediates (GO:0000712)3.50007479
11regulation of DNA endoreduplication (GO:0032875)3.40601821
12proteasome assembly (GO:0043248)3.31442166
13DNA deamination (GO:0045006)3.30413228
14DNA replication checkpoint (GO:0000076)3.29944110
15replication fork processing (GO:0031297)3.25576811
16chromosome organization involved in meiosis (GO:0070192)3.24903764
17RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18469039
18behavioral response to nicotine (GO:0035095)3.16979452
19respiratory chain complex IV assembly (GO:0008535)3.16945324
20protein complex biogenesis (GO:0070271)3.12075161
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09186341
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09053036
23centriole replication (GO:0007099)3.08115627
24meiosis I (GO:0007127)3.07765129
25response to pheromone (GO:0019236)3.06836280
26cullin deneddylation (GO:0010388)3.04460972
27chromatin remodeling at centromere (GO:0031055)3.02059348
28protein K6-linked ubiquitination (GO:0085020)3.01764791
29histone exchange (GO:0043486)2.98151095
30lactate metabolic process (GO:0006089)2.98065868
31mitochondrial respiratory chain complex assembly (GO:0033108)2.95331251
32cytochrome complex assembly (GO:0017004)2.88991750
33mitochondrial respiratory chain complex I assembly (GO:0032981)2.87951697
34NADH dehydrogenase complex assembly (GO:0010257)2.87951697
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87951697
36recombinational repair (GO:0000725)2.84775509
37regulation of hexokinase activity (GO:1903299)2.84417692
38regulation of glucokinase activity (GO:0033131)2.84417692
39CENP-A containing nucleosome assembly (GO:0034080)2.84370077
40double-strand break repair via homologous recombination (GO:0000724)2.84290254
41protein deneddylation (GO:0000338)2.83756389
42meiotic cell cycle (GO:0051321)2.81636631
43prenylation (GO:0097354)2.80697633
44protein prenylation (GO:0018342)2.80697633
45protein polyglutamylation (GO:0018095)2.80573513
46DNA catabolic process, exonucleolytic (GO:0000738)2.79661766
47reciprocal meiotic recombination (GO:0007131)2.79525128
48reciprocal DNA recombination (GO:0035825)2.79525128
49somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76772691
50somatic hypermutation of immunoglobulin genes (GO:0016446)2.76772691
51positive regulation of meiosis (GO:0045836)2.71255761
52maturation of 5.8S rRNA (GO:0000460)2.70842150
53rRNA modification (GO:0000154)2.70613722
54rRNA methylation (GO:0031167)2.70598780
55axoneme assembly (GO:0035082)2.67822035
56inositol phosphate catabolic process (GO:0071545)2.66227399
57sister chromatid cohesion (GO:0007062)2.65788607
58regulation of nuclear cell cycle DNA replication (GO:0033262)2.65163954
59single strand break repair (GO:0000012)2.63991316
60regulation of acrosome reaction (GO:0060046)2.60807691
61meiotic nuclear division (GO:0007126)2.59550991
62regulation of mitotic spindle checkpoint (GO:1903504)2.58837424
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58837424
64meiotic cell cycle process (GO:1903046)2.56317876
65histone H2A acetylation (GO:0043968)2.55778766
66epithelial cilium movement (GO:0003351)2.55308502
67DNA replication-dependent nucleosome assembly (GO:0006335)2.52994103
68DNA replication-dependent nucleosome organization (GO:0034723)2.52994103
69positive regulation of histone H3-K4 methylation (GO:0051571)2.52003365
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51259578
71transcription elongation from RNA polymerase III promoter (GO:0006385)2.50952817
72termination of RNA polymerase III transcription (GO:0006386)2.50952817
73positive regulation of meiotic cell cycle (GO:0051446)2.50227921
74regulation of cilium movement (GO:0003352)2.48637896
75gene silencing by RNA (GO:0031047)2.45989185
76gamma-aminobutyric acid transport (GO:0015812)2.45393781
77negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44524374
78regulation of centriole replication (GO:0046599)2.41720871
79nonmotile primary cilium assembly (GO:0035058)2.41160099
80sperm motility (GO:0030317)2.40197406
81retinal cone cell development (GO:0046549)2.39844884
82protein K11-linked deubiquitination (GO:0035871)2.38918659
83L-fucose catabolic process (GO:0042355)2.38684961
84fucose catabolic process (GO:0019317)2.38684961
85L-fucose metabolic process (GO:0042354)2.38684961
86somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.38395924
87isotype switching (GO:0045190)2.38395924
88somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.38395924
89inositol phosphate dephosphorylation (GO:0046855)2.36262070
90phosphorylated carbohydrate dephosphorylation (GO:0046838)2.36262070
91positive regulation of mitochondrial fission (GO:0090141)2.35268941
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.34879706
93presynaptic membrane assembly (GO:0097105)2.33986096
94preassembly of GPI anchor in ER membrane (GO:0016254)2.33044019
95acrosome reaction (GO:0007340)2.30373821
96intraciliary transport (GO:0042073)2.28138110
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.27522507
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.27522507
99regulation of centrosome cycle (GO:0046605)2.26934047
100protein neddylation (GO:0045116)2.24903298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.75062006
2ZNF274_21170338_ChIP-Seq_K562_Hela3.24925580
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14439190
4VDR_22108803_ChIP-Seq_LS180_Human2.70199115
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.65223170
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.58115113
7EZH2_22144423_ChIP-Seq_EOC_Human2.53310503
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.49744434
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48355613
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46426183
11FUS_26573619_Chip-Seq_HEK293_Human2.36841116
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34890750
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33759474
14IGF1R_20145208_ChIP-Seq_DFB_Human2.28663062
15GBX2_23144817_ChIP-Seq_PC3_Human2.20408055
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18542763
17EWS_26573619_Chip-Seq_HEK293_Human2.11011920
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06018448
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.93673476
20P300_19829295_ChIP-Seq_ESCs_Human1.91059485
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84205346
22TAF15_26573619_Chip-Seq_HEK293_Human1.82133425
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81563674
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74831806
25ELK1_19687146_ChIP-ChIP_HELA_Human1.69044700
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64340382
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63279196
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61688794
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58946292
30E2F7_22180533_ChIP-Seq_HELA_Human1.58119160
31MYC_18940864_ChIP-ChIP_HL60_Human1.56333001
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52441899
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.52386729
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51712244
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50412713
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48927820
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.48123598
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47917989
39CBP_20019798_ChIP-Seq_JUKART_Human1.46865208
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46865208
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45754511
42VDR_23849224_ChIP-Seq_CD4+_Human1.43405828
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41411778
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39740825
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37926353
46ER_23166858_ChIP-Seq_MCF-7_Human1.37914499
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37477130
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37411844
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35476155
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32429600
51TP53_22573176_ChIP-Seq_HFKS_Human1.32236483
52NANOG_19829295_ChIP-Seq_ESCs_Human1.30572109
53SOX2_19829295_ChIP-Seq_ESCs_Human1.30572109
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30242067
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30014181
56SMAD4_21799915_ChIP-Seq_A2780_Human1.29496264
57STAT3_23295773_ChIP-Seq_U87_Human1.26217554
58RNF2_27304074_Chip-Seq_NSC_Mouse1.23969939
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.23341687
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22772544
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.22269364
62IRF1_19129219_ChIP-ChIP_H3396_Human1.21894276
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21661786
64FOXP3_21729870_ChIP-Seq_TREG_Human1.21001862
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20751945
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20511700
67AR_25329375_ChIP-Seq_VCAP_Human1.19712542
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19015945
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16946444
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.16362222
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16362222
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.16336599
73TCF4_23295773_ChIP-Seq_U87_Human1.16141935
74BCAT_22108803_ChIP-Seq_LS180_Human1.15784295
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.14647439
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13714244
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13669222
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11681949
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.09401381
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08337310
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08058899
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07181646
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07181646
84TCF4_22108803_ChIP-Seq_LS180_Human1.07152551
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.06099878
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.05896968
87HTT_18923047_ChIP-ChIP_STHdh_Human1.05347698
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05060258
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04177338
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02968530
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02716652
92RUNX2_22187159_ChIP-Seq_PCA_Human1.01829227
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00544359
94NCOR_22424771_ChIP-Seq_293T_Human1.00454142
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00163299
96PIAS1_25552417_ChIP-Seq_VCAP_Human0.99186461
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.98570697
98P53_22387025_ChIP-Seq_ESCs_Mouse0.98297599
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97342852
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97121985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.68254394
2MP0006292_abnormal_olfactory_placode3.30205285
3MP0008058_abnormal_DNA_repair2.70728125
4MP0003787_abnormal_imprinting2.54201664
5MP0003195_calcinosis2.54060888
6MP0002102_abnormal_ear_morphology2.34922846
7MP0002837_dystrophic_cardiac_calcinosis2.21398964
8MP0003718_maternal_effect2.19118957
9MP0005646_abnormal_pituitary_gland2.09114406
10MP0000372_irregular_coat_pigmentation2.09105903
11MP0008789_abnormal_olfactory_epithelium2.03498522
12MP0002160_abnormal_reproductive_system2.01035772
13MP0003646_muscle_fatigue1.98653984
14MP0003121_genomic_imprinting1.93084382
15MP0005551_abnormal_eye_electrophysiolog1.86253437
16MP0006072_abnormal_retinal_apoptosis1.80268447
17MP0005379_endocrine/exocrine_gland_phen1.79616287
18MP0010094_abnormal_chromosome_stability1.77981595
19MP0003880_abnormal_central_pattern1.73401548
20MP0002163_abnormal_gland_morphology1.72501459
21MP0001929_abnormal_gametogenesis1.66294725
22MP0001984_abnormal_olfaction1.63370598
23MP0005389_reproductive_system_phenotype1.62087369
24MP0000631_abnormal_neuroendocrine_gland1.59000113
25MP0002210_abnormal_sex_determination1.58584406
26MP0009046_muscle_twitch1.56239319
27MP0004147_increased_porphyrin_level1.53058381
28MP0005394_taste/olfaction_phenotype1.49829213
29MP0005499_abnormal_olfactory_system1.49829213
30MP0008995_early_reproductive_senescence1.49367911
31MP0005253_abnormal_eye_physiology1.46793583
32MP0003890_abnormal_embryonic-extraembry1.45582607
33MP0005410_abnormal_fertilization1.42377925
34MP0002938_white_spotting1.41851580
35MP0001968_abnormal_touch/_nociception1.38877973
36MP0001485_abnormal_pinna_reflex1.37392136
37MP0003122_maternal_imprinting1.37301677
38MP0006276_abnormal_autonomic_nervous1.35597690
39MP0002638_abnormal_pupillary_reflex1.34884951
40MP0003123_paternal_imprinting1.34615967
41MP0000653_abnormal_sex_gland1.34041142
42MP0003698_abnormal_male_reproductive1.33881542
43MP0001145_abnormal_male_reproductive1.30548911
44MP0008057_abnormal_DNA_replication1.30435632
45MP0002876_abnormal_thyroid_physiology1.29920936
46MP0002272_abnormal_nervous_system1.29720046
47MP0003786_premature_aging1.29068861
48MP0003693_abnormal_embryo_hatching1.28209115
49MP0004142_abnormal_muscle_tone1.26926364
50MP0008872_abnormal_physiological_respon1.26240504
51MP0009745_abnormal_behavioral_response1.25696807
52MP0003119_abnormal_digestive_system1.24641315
53MP0009780_abnormal_chondrocyte_physiolo1.23850967
54MP0003011_delayed_dark_adaptation1.23524066
55MP0005645_abnormal_hypothalamus_physiol1.23479139
56MP0005084_abnormal_gallbladder_morpholo1.15158182
57MP0004133_heterotaxia1.13854738
58MP0002736_abnormal_nociception_after1.11815298
59MP0004215_abnormal_myocardial_fiber1.11743955
60MP0006036_abnormal_mitochondrial_physio1.10595269
61MP0006035_abnormal_mitochondrial_morpho1.09332589
62MP0003136_yellow_coat_color1.06727864
63MP0001486_abnormal_startle_reflex1.06590984
64MP0003937_abnormal_limbs/digits/tail_de1.06003926
65MP0004270_analgesia1.04954306
66MP0000427_abnormal_hair_cycle1.03069666
67MP0003567_abnormal_fetal_cardiomyocyte1.02948210
68MP0001293_anophthalmia1.02120296
69MP0001986_abnormal_taste_sensitivity1.01188303
70MP0004885_abnormal_endolymph0.99809744
71MP0002928_abnormal_bile_duct0.98885986
72MP0001529_abnormal_vocalization0.98838009
73MP0003111_abnormal_nucleus_morphology0.98584387
74MP0005367_renal/urinary_system_phenotyp0.95892665
75MP0000516_abnormal_urinary_system0.95892665
76MP0002234_abnormal_pharynx_morphology0.95624260
77MP0004145_abnormal_muscle_electrophysio0.95031386
78MP0002138_abnormal_hepatobiliary_system0.94767347
79MP0003283_abnormal_digestive_organ0.94458000
80MP0002751_abnormal_autonomic_nervous0.94037932
81MP0002734_abnormal_mechanical_nocicepti0.93614864
82MP0005332_abnormal_amino_acid0.91128867
83MP0001119_abnormal_female_reproductive0.91103423
84MP0002557_abnormal_social/conspecific_i0.90989256
85MP0001919_abnormal_reproductive_system0.86536303
86MP0002090_abnormal_vision0.84225942
87MP0005075_abnormal_melanosome_morpholog0.83594912
88MP0004957_abnormal_blastocyst_morpholog0.83427749
89MP0001944_abnormal_pancreas_morphology0.82057672
90MP0005195_abnormal_posterior_eye0.82017245
91MP0000049_abnormal_middle_ear0.80492089
92MP0001324_abnormal_eye_pigmentation0.80328845
93MP0002161_abnormal_fertility/fecundity0.79540775
94MP0002572_abnormal_emotion/affect_behav0.79413625
95MP0003938_abnormal_ear_development0.77319055
96MP0005174_abnormal_tail_pigmentation0.76376993
97MP0005395_other_phenotype0.74430842
98MP0002277_abnormal_respiratory_mucosa0.74090360
99MP0001905_abnormal_dopamine_level0.73021495
100MP0003137_abnormal_impulse_conducting0.72666590

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.45292794
2Pancreatic fibrosis (HP:0100732)3.23677379
3Abnormality of the labia minora (HP:0012880)3.14687574
4Methylmalonic acidemia (HP:0002912)3.11493039
5Volvulus (HP:0002580)3.04406737
6Abnormality of midbrain morphology (HP:0002418)2.99183160
7Molar tooth sign on MRI (HP:0002419)2.99183160
8True hermaphroditism (HP:0010459)2.97095496
9Nephronophthisis (HP:0000090)2.79758865
10Medial flaring of the eyebrow (HP:0010747)2.75800140
11Acute encephalopathy (HP:0006846)2.55679587
12Acute necrotizing encephalopathy (HP:0006965)2.53557275
13Hypothermia (HP:0002045)2.53470760
14Progressive macrocephaly (HP:0004481)2.52834163
15Congenital stationary night blindness (HP:0007642)2.46949674
16Chromsome breakage (HP:0040012)2.44101467
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42198145
18Methylmalonic aciduria (HP:0012120)2.40894411
19Abnormality of the renal cortex (HP:0011035)2.39167984
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.38279141
21Abnormality of the renal medulla (HP:0100957)2.33579212
22Chronic hepatic failure (HP:0100626)2.33561398
23Pendular nystagmus (HP:0012043)2.33057976
24Abnormality of the ileum (HP:0001549)2.29913054
25Increased CSF lactate (HP:0002490)2.27022196
26Meckel diverticulum (HP:0002245)2.23126131
27Hyperglycinemia (HP:0002154)2.23078888
28Ectopic kidney (HP:0000086)2.20435580
29Abolished electroretinogram (ERG) (HP:0000550)2.17665125
30Congenital primary aphakia (HP:0007707)2.16193874
31Gait imbalance (HP:0002141)2.15666577
32Intestinal atresia (HP:0011100)2.13610703
33Abnormality of vitamin B metabolism (HP:0004340)2.13027357
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12898489
35Male pseudohermaphroditism (HP:0000037)2.12616010
36Renal cortical cysts (HP:0000803)2.10229403
37Mitochondrial inheritance (HP:0001427)2.09740853
38Neoplasm of the adrenal cortex (HP:0100641)2.09109917
39Type II lissencephaly (HP:0007260)2.07567813
40Supernumerary spleens (HP:0009799)2.07406380
41Abnormal mitochondria in muscle tissue (HP:0008316)2.06316892
42Nephrogenic diabetes insipidus (HP:0009806)2.06277700
43Abnormality of chromosome stability (HP:0003220)2.04898078
44Abnormality of alanine metabolism (HP:0010916)2.03830928
45Hyperalaninemia (HP:0003348)2.03830928
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03830928
47Sclerocornea (HP:0000647)2.03335732
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.02810438
493-Methylglutaconic aciduria (HP:0003535)1.99102188
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96883577
51Hypoplasia of the fovea (HP:0007750)1.94967432
52Aplasia/Hypoplasia of the fovea (HP:0008060)1.94967432
53Attenuation of retinal blood vessels (HP:0007843)1.94817329
54Genital tract atresia (HP:0001827)1.94654659
55Abnormality of methionine metabolism (HP:0010901)1.93180536
56Oligodactyly (hands) (HP:0001180)1.93145224
57Cystic liver disease (HP:0006706)1.92878761
58Hypoglycemic coma (HP:0001325)1.91041488
59Colon cancer (HP:0003003)1.89384754
60Abnormality of the preputium (HP:0100587)1.89354453
61Absent thumb (HP:0009777)1.89279679
62Abnormality of the vitamin B12 metabolism (HP:0004341)1.87331508
63Adrenal hypoplasia (HP:0000835)1.86729291
64Gaze-evoked nystagmus (HP:0000640)1.86632267
65Hepatic necrosis (HP:0002605)1.85605380
66Optic nerve hypoplasia (HP:0000609)1.84712944
67Hypoglycemic seizures (HP:0002173)1.83306899
68Furrowed tongue (HP:0000221)1.81917653
69Vaginal atresia (HP:0000148)1.81687317
70Median cleft lip (HP:0000161)1.81077018
71Anencephaly (HP:0002323)1.80566695
72Hypomagnesemia (HP:0002917)1.80001881
73Septo-optic dysplasia (HP:0100842)1.78881003
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.78739218
75Preaxial hand polydactyly (HP:0001177)1.78584447
76Hepatocellular necrosis (HP:0001404)1.77429065
77Ketoacidosis (HP:0001993)1.75898551
78Abnormality of glycine metabolism (HP:0010895)1.75340860
79Abnormality of serine family amino acid metabolism (HP:0010894)1.75340860
80Ependymoma (HP:0002888)1.75241465
81Hyperinsulinemic hypoglycemia (HP:0000825)1.75063206
82Agitation (HP:0000713)1.74721754
83Abnormality of serum amino acid levels (HP:0003112)1.74209352
84Small intestinal stenosis (HP:0012848)1.74135056
85Duodenal stenosis (HP:0100867)1.74135056
86Abnormal rod and cone electroretinograms (HP:0008323)1.73706557
87Short tibia (HP:0005736)1.73503584
88Sloping forehead (HP:0000340)1.72122237
89Hyperglycinuria (HP:0003108)1.71606836
90Postaxial foot polydactyly (HP:0001830)1.71569697
91Progressive inability to walk (HP:0002505)1.71414284
92Homocystinuria (HP:0002156)1.70752854
93Abnormality of homocysteine metabolism (HP:0010919)1.70752854
94Bony spicule pigmentary retinopathy (HP:0007737)1.70720354
95Small hand (HP:0200055)1.70566681
96Aplasia/hypoplasia of the uterus (HP:0008684)1.69570689
97Abnormality of the duodenum (HP:0002246)1.68642199
98Broad-based gait (HP:0002136)1.67517423
99Tubular atrophy (HP:0000092)1.67473801
100Horseshoe kidney (HP:0000085)1.67166447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.98067400
2TRIM282.72901574
3WNK32.72143632
4NUAK12.68872845
5TNIK2.58512864
6PLK42.24542300
7MAP4K22.21434324
8PLK22.08830393
9ADRBK22.07119731
10ZAK2.06469680
11BMPR1B2.05518132
12GRK12.03328659
13PNCK1.99973622
14BUB11.93090836
15EIF2AK31.92715697
16PLK31.89686723
17ACVR1B1.83449027
18MAP3K41.79180776
19MST41.75637582
20FGFR21.67043141
21CDC71.64879344
22PINK11.61251877
23STK161.57022566
24BRSK21.56340733
25MKNK21.54486269
26TSSK61.45800088
27PDK21.39463524
28CASK1.34170696
29INSRR1.31102743
30VRK11.29804587
31MAP2K71.25029540
32TTK1.21985194
33MAPK131.21561398
34PLK11.19083248
35EIF2AK11.12568901
36CSNK1G11.11897894
37VRK21.09559627
38SRPK11.09332640
39CSNK1G31.06031364
40MKNK11.04471321
41NEK11.04239121
42CSNK1G21.02375035
43WEE10.96045649
44PRKCG0.94749741
45NTRK30.90292452
46PRKCE0.89931375
47OXSR10.89529673
48STK390.88396725
49STK30.88181895
50PAK30.88130673
51WNK40.88082538
52ERBB30.84388954
53MAP3K90.84329043
54CSNK1A1L0.84104500
55PASK0.83401532
56PHKG20.82715052
57PHKG10.82715052
58DYRK20.82581281
59ATR0.82486837
60BCR0.80105967
61TIE10.79592490
62STK38L0.78467769
63NME10.73779373
64MUSK0.73647476
65BRSK10.71037920
66ATM0.68639179
67BCKDK0.64686938
68TLK10.62821690
69CHEK20.59548572
70PRKCI0.58162003
71EPHA40.57564748
72NLK0.57550669
73TAF10.57388964
74MARK10.56580973
75TAOK30.51867136
76DAPK20.51099002
77CAMK2A0.47259695
78EIF2AK20.45036352
79TGFBR10.44367554
80CAMK1G0.42442245
81CSNK1A10.41857576
82BRD40.41794590
83DYRK30.41391320
84PRKACA0.40452895
85CCNB10.40245281
86CSNK1E0.39762304
87MINK10.38721918
88ADRBK10.38265056
89CSNK2A10.37582276
90NTRK20.37020561
91CHEK10.36975222
92PRKDC0.34817315
93CSNK1D0.34605243
94OBSCN0.33665426
95CSNK2A20.32917944
96PRKG10.32863717
97AURKA0.32110328
98PRKAA10.31992315
99PBK0.31925874
100MAPKAPK50.31907819

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.97524547
2Protein export_Homo sapiens_hsa030602.89516485
3Homologous recombination_Homo sapiens_hsa034402.81384752
4Mismatch repair_Homo sapiens_hsa034302.39642522
5Basal transcription factors_Homo sapiens_hsa030222.32604596
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30118131
7RNA polymerase_Homo sapiens_hsa030202.28260438
8Fanconi anemia pathway_Homo sapiens_hsa034602.25449655
9Oxidative phosphorylation_Homo sapiens_hsa001902.19807612
10Proteasome_Homo sapiens_hsa030502.16161410
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15538160
12RNA degradation_Homo sapiens_hsa030182.11935499
13Phototransduction_Homo sapiens_hsa047442.11503199
14Non-homologous end-joining_Homo sapiens_hsa034502.07716705
15Butanoate metabolism_Homo sapiens_hsa006502.02759267
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96723410
17Propanoate metabolism_Homo sapiens_hsa006401.95589458
18DNA replication_Homo sapiens_hsa030301.93236310
19Parkinsons disease_Homo sapiens_hsa050121.86090959
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77569523
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74669438
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68187324
23Selenocompound metabolism_Homo sapiens_hsa004501.67450859
24Nicotine addiction_Homo sapiens_hsa050331.55432462
25RNA transport_Homo sapiens_hsa030131.55265671
26One carbon pool by folate_Homo sapiens_hsa006701.36452621
27Huntingtons disease_Homo sapiens_hsa050161.34825707
28Vitamin B6 metabolism_Homo sapiens_hsa007501.33338021
29Nucleotide excision repair_Homo sapiens_hsa034201.31619554
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31520486
31Sulfur metabolism_Homo sapiens_hsa009201.27031945
32Steroid biosynthesis_Homo sapiens_hsa001001.22741387
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.20881805
34Folate biosynthesis_Homo sapiens_hsa007901.20351333
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18743348
36Olfactory transduction_Homo sapiens_hsa047401.15596622
37Base excision repair_Homo sapiens_hsa034101.15265106
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15240454
39Caffeine metabolism_Homo sapiens_hsa002321.11452878
40Oocyte meiosis_Homo sapiens_hsa041141.09723676
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07502366
42Tryptophan metabolism_Homo sapiens_hsa003801.05972366
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05861355
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04983940
45Fatty acid elongation_Homo sapiens_hsa000621.04649358
46Linoleic acid metabolism_Homo sapiens_hsa005911.04539090
47Purine metabolism_Homo sapiens_hsa002301.03535464
48Regulation of autophagy_Homo sapiens_hsa041401.03506475
49Alzheimers disease_Homo sapiens_hsa050101.03042391
50Peroxisome_Homo sapiens_hsa041461.02847826
51Pyruvate metabolism_Homo sapiens_hsa006201.02150057
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99973448
53Cardiac muscle contraction_Homo sapiens_hsa042600.97961811
54Pyrimidine metabolism_Homo sapiens_hsa002400.97847920
55Cell cycle_Homo sapiens_hsa041100.95886662
56Spliceosome_Homo sapiens_hsa030400.90973094
57Taste transduction_Homo sapiens_hsa047420.89806939
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87639371
59Insulin secretion_Homo sapiens_hsa049110.83592100
60Collecting duct acid secretion_Homo sapiens_hsa049660.83180759
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81019434
62Ether lipid metabolism_Homo sapiens_hsa005650.77822095
63Retinol metabolism_Homo sapiens_hsa008300.77554520
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76103636
65beta-Alanine metabolism_Homo sapiens_hsa004100.75069251
66Nitrogen metabolism_Homo sapiens_hsa009100.74338166
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73433074
68Metabolic pathways_Homo sapiens_hsa011000.71663313
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.71126213
70Morphine addiction_Homo sapiens_hsa050320.65060797
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64171619
72Chemical carcinogenesis_Homo sapiens_hsa052040.62729507
73p53 signaling pathway_Homo sapiens_hsa041150.61975227
74GABAergic synapse_Homo sapiens_hsa047270.61242913
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59325072
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57532277
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57290256
78Fatty acid degradation_Homo sapiens_hsa000710.57125045
79Fatty acid metabolism_Homo sapiens_hsa012120.53954063
80Circadian rhythm_Homo sapiens_hsa047100.50219955
81Vitamin digestion and absorption_Homo sapiens_hsa049770.48346619
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.47583457
83Glutathione metabolism_Homo sapiens_hsa004800.47361449
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47059059
85Fat digestion and absorption_Homo sapiens_hsa049750.46967116
86Serotonergic synapse_Homo sapiens_hsa047260.46625314
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44700979
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44567224
89mRNA surveillance pathway_Homo sapiens_hsa030150.44338624
90Dorso-ventral axis formation_Homo sapiens_hsa043200.43395217
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41070249
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39520081
93Circadian entrainment_Homo sapiens_hsa047130.39083606
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38193548
95Hedgehog signaling pathway_Homo sapiens_hsa043400.37783334
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37770191
97Ovarian steroidogenesis_Homo sapiens_hsa049130.34782812
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33645128
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32482635
100Type II diabetes mellitus_Homo sapiens_hsa049300.31838363

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