ZNF280C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)5.39348083
2piRNA metabolic process (GO:0034587)4.70898332
3DNA methylation involved in gamete generation (GO:0043046)4.29496559
4centriole replication (GO:0007099)4.21907462
5chromatin remodeling at centromere (GO:0031055)4.20782003
6synapsis (GO:0007129)4.18702163
7CENP-A containing nucleosome assembly (GO:0034080)4.11623806
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.10386831
9meiotic chromosome segregation (GO:0045132)4.08611649
10DNA double-strand break processing (GO:0000729)4.07825393
11regulation of centriole replication (GO:0046599)3.91927810
12protein localization to kinetochore (GO:0034501)3.80957231
13mitotic metaphase plate congression (GO:0007080)3.76419347
14regulation of nuclear cell cycle DNA replication (GO:0033262)3.66563348
15metaphase plate congression (GO:0051310)3.66397920
16histone exchange (GO:0043486)3.63912967
17kinetochore organization (GO:0051383)3.59404802
18attachment of spindle microtubules to kinetochore (GO:0008608)3.58492711
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57178656
20regulation of mitotic spindle checkpoint (GO:1903504)3.57178656
21negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.56281453
22DNA replication checkpoint (GO:0000076)3.55589834
23replication fork processing (GO:0031297)3.49022896
24nuclear pore organization (GO:0006999)3.45739352
25spindle checkpoint (GO:0031577)3.44140049
26reciprocal meiotic recombination (GO:0007131)3.42596594
27reciprocal DNA recombination (GO:0035825)3.42596594
28nuclear pore complex assembly (GO:0051292)3.38989590
29regulation of DNA endoreduplication (GO:0032875)3.37175434
30mitotic spindle checkpoint (GO:0071174)3.36024791
31regulation of mitotic metaphase/anaphase transition (GO:0030071)3.34188143
32regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.34188143
33negative regulation of chromosome segregation (GO:0051985)3.33923802
34kinetochore assembly (GO:0051382)3.32342744
35negative regulation of mitotic sister chromatid separation (GO:2000816)3.31076079
36negative regulation of sister chromatid segregation (GO:0033046)3.31076079
37negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.31076079
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31076079
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.31076079
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.26751656
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.26751656
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.26751656
43regulation of centrosome cycle (GO:0046605)3.26562354
44regulation of mitotic sister chromatid segregation (GO:0033047)3.25948274
45regulation of sister chromatid segregation (GO:0033045)3.25948274
46regulation of mitotic sister chromatid separation (GO:0010965)3.25948274
47meiotic cell cycle (GO:0051321)3.25039557
48mitotic sister chromatid cohesion (GO:0007064)3.19685830
49DNA replication-dependent nucleosome assembly (GO:0006335)3.19423892
50DNA replication-dependent nucleosome organization (GO:0034723)3.19423892
51protein localization to chromosome, centromeric region (GO:0071459)3.19302409
52sister chromatid cohesion (GO:0007062)3.18945359
53DNA replication-independent nucleosome organization (GO:0034724)3.17163378
54DNA replication-independent nucleosome assembly (GO:0006336)3.17163378
55mitotic spindle assembly checkpoint (GO:0007094)3.16952138
56spindle assembly checkpoint (GO:0071173)3.16127759
57gene silencing by RNA (GO:0031047)3.14727492
58mitotic sister chromatid segregation (GO:0000070)3.13578465
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.13161049
60protein K6-linked ubiquitination (GO:0085020)3.10922873
61sister chromatid segregation (GO:0000819)3.07341116
62regulation of centrosome duplication (GO:0010824)3.06599762
63postreplication repair (GO:0006301)3.06599246
64male meiosis I (GO:0007141)3.04562170
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02015763
66negative regulation of cell cycle G2/M phase transition (GO:1902750)3.01044347
67resolution of meiotic recombination intermediates (GO:0000712)3.00806118
68establishment of chromosome localization (GO:0051303)3.00059258
69regulation of chromosome segregation (GO:0051983)2.97456200
70protein localization to chromosome (GO:0034502)2.97240958
71chromosome organization involved in meiosis (GO:0070192)2.93839300
72recombinational repair (GO:0000725)2.92340892
73double-strand break repair via homologous recombination (GO:0000724)2.89077855
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88991698
75meiotic cell cycle process (GO:1903046)2.87676506
76histone H2A acetylation (GO:0043968)2.87100552
77centriole assembly (GO:0098534)2.86514577
78somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85626222
79somatic hypermutation of immunoglobulin genes (GO:0016446)2.85626222
80male meiosis (GO:0007140)2.84684986
81mitotic nuclear envelope disassembly (GO:0007077)2.84433833
82positive regulation of chromosome segregation (GO:0051984)2.81142263
83DNA strand elongation involved in DNA replication (GO:0006271)2.79899577
84telomere maintenance via semi-conservative replication (GO:0032201)2.76777496
85non-recombinational repair (GO:0000726)2.76542849
86double-strand break repair via nonhomologous end joining (GO:0006303)2.76542849
87microtubule depolymerization (GO:0007019)2.74148489
88meiosis I (GO:0007127)2.73721200
89DNA ligation (GO:0006266)2.72875656
90translesion synthesis (GO:0019985)2.72766010
91negative regulation of mitosis (GO:0045839)2.72310159
92female gamete generation (GO:0007292)2.72045927
93DNA catabolic process, exonucleolytic (GO:0000738)2.71756826
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71684748
95proteasome assembly (GO:0043248)2.69982606
96DNA strand elongation (GO:0022616)2.69883757
97microtubule anchoring (GO:0034453)2.69054317
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.68183163
99mitotic recombination (GO:0006312)2.67226845
100positive regulation of developmental pigmentation (GO:0048087)2.66535156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.22165603
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34691058
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22921945
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.00462206
5IGF1R_20145208_ChIP-Seq_DFB_Human2.86128661
6ZNF274_21170338_ChIP-Seq_K562_Hela2.83755732
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77431519
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.61489822
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56567745
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.46802638
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.44852885
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32317898
13FUS_26573619_Chip-Seq_HEK293_Human2.28257969
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26752227
15EWS_26573619_Chip-Seq_HEK293_Human2.24235927
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20743304
17EZH2_22144423_ChIP-Seq_EOC_Human2.20562989
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17936479
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17793423
20ELK1_19687146_ChIP-ChIP_HELA_Human2.14261714
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13644067
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02601080
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02079796
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94936596
25VDR_22108803_ChIP-Seq_LS180_Human1.92015089
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.88615455
27TAF15_26573619_Chip-Seq_HEK293_Human1.85396955
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79001790
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.77165791
30VDR_23849224_ChIP-Seq_CD4+_Human1.76433085
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75540854
32P300_19829295_ChIP-Seq_ESCs_Human1.74436593
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73924549
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73549524
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72713224
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.66217117
37GBX2_23144817_ChIP-Seq_PC3_Human1.65993606
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65527541
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64770955
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60427785
41FOXP3_21729870_ChIP-Seq_TREG_Human1.55912821
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54974221
43MYC_18940864_ChIP-ChIP_HL60_Human1.50435755
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.48076484
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.46189148
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45191993
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44122013
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40241426
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.33568597
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31344707
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28115976
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26751088
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26152030
54IRF1_19129219_ChIP-ChIP_H3396_Human1.23910778
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23789855
56CBP_20019798_ChIP-Seq_JUKART_Human1.23789855
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20602570
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.19640215
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19471982
60ER_23166858_ChIP-Seq_MCF-7_Human1.18887912
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18863804
62AR_21909140_ChIP-Seq_LNCAP_Human1.13892740
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.12349770
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11813767
65STAT3_23295773_ChIP-Seq_U87_Human1.10835225
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10782527
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10494104
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10335523
69DCP1A_22483619_ChIP-Seq_HELA_Human1.10062583
70SMAD4_21799915_ChIP-Seq_A2780_Human1.09195232
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08589871
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07284716
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06762956
74AR_21572438_ChIP-Seq_LNCaP_Human1.06305192
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06300868
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.05802455
77TCF4_23295773_ChIP-Seq_U87_Human1.02964725
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02824698
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02722091
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.02415000
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01288893
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.01117147
83AR_25329375_ChIP-Seq_VCAP_Human1.00987573
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00942709
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99338174
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98868490
87GABP_19822575_ChIP-Seq_HepG2_Human0.98859704
88TTF2_22483619_ChIP-Seq_HELA_Human0.98722666
89RNF2_27304074_Chip-Seq_NSC_Mouse0.98083059
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97945803
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97945803
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97629965
93TP53_22573176_ChIP-Seq_HFKS_Human0.97387525
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96225575
95MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96042897
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95147696
97TCF4_22108803_ChIP-Seq_LS180_Human0.93409774
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92819588
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92111293
100BCAT_22108803_ChIP-Seq_LS180_Human0.91713621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry3.79281966
2MP0008877_abnormal_DNA_methylation3.64396148
3MP0008057_abnormal_DNA_replication3.22227383
4MP0008058_abnormal_DNA_repair3.21132187
5MP0010094_abnormal_chromosome_stability3.19229830
6MP0006292_abnormal_olfactory_placode3.18875755
7MP0003136_yellow_coat_color3.13428255
8MP0003718_maternal_effect2.71411772
9MP0003693_abnormal_embryo_hatching2.60283393
10MP0002837_dystrophic_cardiac_calcinosis2.54995882
11MP0008789_abnormal_olfactory_epithelium2.40258252
12MP0003111_abnormal_nucleus_morphology2.40139310
13MP0002102_abnormal_ear_morphology2.19829385
14MP0004957_abnormal_blastocyst_morpholog2.13619976
15MP0003077_abnormal_cell_cycle2.09918580
16MP0005499_abnormal_olfactory_system2.03776453
17MP0005394_taste/olfaction_phenotype2.03776453
18MP0002938_white_spotting2.03597684
19MP0005171_absent_coat_pigmentation2.02328094
20MP0002653_abnormal_ependyma_morphology2.01173606
21MP0001293_anophthalmia1.95692014
22MP0008932_abnormal_embryonic_tissue1.95056958
23MP0002234_abnormal_pharynx_morphology1.81741899
24MP0000569_abnormal_digit_pigmentation1.72652008
25MP0003121_genomic_imprinting1.66235647
26MP0003937_abnormal_limbs/digits/tail_de1.65830571
27MP0002210_abnormal_sex_determination1.61343148
28MP0002160_abnormal_reproductive_system1.60902034
29MP0001929_abnormal_gametogenesis1.59865713
30MP0009697_abnormal_copulation1.56179906
31MP0010030_abnormal_orbit_morphology1.55870762
32MP0006072_abnormal_retinal_apoptosis1.52293722
33MP0002233_abnormal_nose_morphology1.43062020
34MP0003119_abnormal_digestive_system1.41577135
35MP0008995_early_reproductive_senescence1.38708458
36MP0003646_muscle_fatigue1.37357568
37MP0000631_abnormal_neuroendocrine_gland1.33805543
38MP0000653_abnormal_sex_gland1.31090706
39MP0001145_abnormal_male_reproductive1.29112573
40MP0002751_abnormal_autonomic_nervous1.28185879
41MP0001984_abnormal_olfaction1.25311402
42MP0003195_calcinosis1.24872551
43MP0001529_abnormal_vocalization1.22970668
44MP0000427_abnormal_hair_cycle1.22651480
45MP0002084_abnormal_developmental_patter1.20112784
46MP0000049_abnormal_middle_ear1.19094750
47MP0005395_other_phenotype1.16763624
48MP0003698_abnormal_male_reproductive1.14920257
49MP0001286_abnormal_eye_development1.14342684
50MP0003787_abnormal_imprinting1.12989484
51MP0005645_abnormal_hypothalamus_physiol1.10222433
52MP0005253_abnormal_eye_physiology1.09024473
53MP0005380_embryogenesis_phenotype1.08907110
54MP0001672_abnormal_embryogenesis/_devel1.08907110
55MP0003567_abnormal_fetal_cardiomyocyte1.08242299
56MP0003880_abnormal_central_pattern1.07935939
57MP0000778_abnormal_nervous_system1.07387741
58MP0003786_premature_aging1.06046737
59MP0005389_reproductive_system_phenotype1.05793559
60MP0001119_abnormal_female_reproductive1.05717957
61MP0000566_synostosis1.04691798
62MP0006276_abnormal_autonomic_nervous1.04608571
63MP0008007_abnormal_cellular_replicative1.02768281
64MP0003755_abnormal_palate_morphology1.02199131
65MP0005075_abnormal_melanosome_morpholog1.01935762
66MP0005551_abnormal_eye_electrophysiolog1.01118909
67MP0004133_heterotaxia1.00674218
68MP0002138_abnormal_hepatobiliary_system0.97788613
69MP0002085_abnormal_embryonic_tissue0.96776475
70MP0000372_irregular_coat_pigmentation0.95358720
71MP0002095_abnormal_skin_pigmentation0.92177342
72MP0001697_abnormal_embryo_size0.91960555
73MP0000383_abnormal_hair_follicle0.91629074
74MP0001730_embryonic_growth_arrest0.91442260
75MP0010307_abnormal_tumor_latency0.91146728
76MP0004197_abnormal_fetal_growth/weight/0.90722709
77MP0005391_vision/eye_phenotype0.89073691
78MP0003861_abnormal_nervous_system0.86705673
79MP0001324_abnormal_eye_pigmentation0.85255533
80MP0003935_abnormal_craniofacial_develop0.84950666
81MP0000647_abnormal_sebaceous_gland0.84629561
82MP0002161_abnormal_fertility/fecundity0.83757577
83MP0004142_abnormal_muscle_tone0.83356361
84MP0003385_abnormal_body_wall0.81918139
85MP0003699_abnormal_female_reproductive0.80917455
86MP0002697_abnormal_eye_size0.80399002
87MP0001188_hyperpigmentation0.80256477
88MP0003941_abnormal_skin_development0.78645001
89MP0003984_embryonic_growth_retardation0.78111888
90MP0002088_abnormal_embryonic_growth/wei0.76996899
91MP0002638_abnormal_pupillary_reflex0.76524008
92MP0005248_abnormal_Harderian_gland0.74956837
93MP0003122_maternal_imprinting0.73591885
94MP0001486_abnormal_startle_reflex0.70225114
95MP0006035_abnormal_mitochondrial_morpho0.70223085
96MP0002111_abnormal_tail_morphology0.69918914
97MP0000350_abnormal_cell_proliferation0.69192088
98MP0000428_abnormal_craniofacial_morphol0.67247469
99MP0009703_decreased_birth_body0.66602926
100MP0001986_abnormal_taste_sensitivity0.66046152

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91849538
2Abnormality of the labia minora (HP:0012880)3.87640475
3Chromsome breakage (HP:0040012)3.72515904
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.59018619
5Colon cancer (HP:0003003)3.43013390
6Volvulus (HP:0002580)3.29735761
7Pancreatic cysts (HP:0001737)3.26486526
8Abnormality of chromosome stability (HP:0003220)3.05714965
9Abnormality of midbrain morphology (HP:0002418)2.99838722
10Molar tooth sign on MRI (HP:0002419)2.99838722
11Nephronophthisis (HP:0000090)2.99712898
12Meckel diverticulum (HP:0002245)2.99119513
13Pancreatic fibrosis (HP:0100732)2.99116850
14Abnormality of the ileum (HP:0001549)2.93612750
15Supernumerary spleens (HP:0009799)2.88532918
16Abnormal lung lobation (HP:0002101)2.72316925
17Septo-optic dysplasia (HP:0100842)2.66316453
18Abnormality of the renal medulla (HP:0100957)2.55040639
19Pendular nystagmus (HP:0012043)2.54864296
20Gonadotropin excess (HP:0000837)2.52670525
21True hermaphroditism (HP:0010459)2.52326209
22Tubulointerstitial nephritis (HP:0001970)2.48606351
23Chronic hepatic failure (HP:0100626)2.47738498
24Embryonal renal neoplasm (HP:0011794)2.46715304
25Duodenal stenosis (HP:0100867)2.46263285
26Small intestinal stenosis (HP:0012848)2.46263285
27Nephroblastoma (Wilms tumor) (HP:0002667)2.45413011
28Aplasia/Hypoplasia of the tongue (HP:0010295)2.42399530
29Abnormality of the preputium (HP:0100587)2.42157828
30Oligodactyly (hands) (HP:0001180)2.41988229
31Birth length less than 3rd percentile (HP:0003561)2.40308272
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.37910572
33Ectopic kidney (HP:0000086)2.32307301
34Sloping forehead (HP:0000340)2.30758518
35Medial flaring of the eyebrow (HP:0010747)2.26867292
36Abnormality of the duodenum (HP:0002246)2.24199260
37Intestinal atresia (HP:0011100)2.19193953
38Medulloblastoma (HP:0002885)2.19167582
39Preaxial hand polydactyly (HP:0001177)2.17889563
40Oligodactyly (HP:0012165)2.12164150
41Triphalangeal thumb (HP:0001199)2.11852953
42Absent radius (HP:0003974)2.11745043
43Genital tract atresia (HP:0001827)2.11621759
44Median cleft lip (HP:0000161)2.09238600
45Short tibia (HP:0005736)2.09145507
46Postaxial foot polydactyly (HP:0001830)2.08866957
47Aplasia involving forearm bones (HP:0009822)2.06804067
48Absent forearm bone (HP:0003953)2.06804067
49Optic nerve hypoplasia (HP:0000609)2.06004048
50Abnormality of the carotid arteries (HP:0005344)2.03644244
51Absent septum pellucidum (HP:0001331)2.03612623
52Cortical dysplasia (HP:0002539)1.99111746
53Bifid tongue (HP:0010297)1.99086954
54Progressive inability to walk (HP:0002505)1.97463972
55Abnormality of the renal cortex (HP:0011035)1.95846461
56Gastrointestinal atresia (HP:0002589)1.94450253
57Congenital primary aphakia (HP:0007707)1.93611455
58Glioma (HP:0009733)1.93608629
59Patellar aplasia (HP:0006443)1.92974103
60Clubbing of toes (HP:0100760)1.89384912
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88886696
62Dandy-Walker malformation (HP:0001305)1.88187768
63Vaginal atresia (HP:0000148)1.87896228
64Facial hemangioma (HP:0000329)1.87298292
65Abnormality of the septum pellucidum (HP:0007375)1.86296472
66Anencephaly (HP:0002323)1.85607716
67Gait imbalance (HP:0002141)1.85437686
68Abnormal biliary tract physiology (HP:0012439)1.84909690
69Bile duct proliferation (HP:0001408)1.84909690
70Nephrogenic diabetes insipidus (HP:0009806)1.84063124
71Postaxial hand polydactyly (HP:0001162)1.83376869
72Neoplasm of the colon (HP:0100273)1.79399818
73Aplasia/Hypoplasia of the patella (HP:0006498)1.77218288
74Aplastic anemia (HP:0001915)1.75650393
75Neoplasm of the adrenal cortex (HP:0100641)1.74859405
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73489163
77Abnormality of alanine metabolism (HP:0010916)1.73489163
78Hyperalaninemia (HP:0003348)1.73489163
79Astigmatism (HP:0000483)1.70655625
80Increased nuchal translucency (HP:0010880)1.70398158
81Hyperglycinemia (HP:0002154)1.70208561
82Tubular atrophy (HP:0000092)1.70125190
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.66656529
84Cystic liver disease (HP:0006706)1.65732157
85Myelodysplasia (HP:0002863)1.64744773
86Small hand (HP:0200055)1.64160783
87Hypoplastic labia majora (HP:0000059)1.64061356
88Hypoplastic pelvis (HP:0008839)1.63818764
89Ependymoma (HP:0002888)1.63778176
90Short thumb (HP:0009778)1.62831642
91Congenital hepatic fibrosis (HP:0002612)1.62393614
92Sclerocornea (HP:0000647)1.61871450
93Poor coordination (HP:0002370)1.61825481
94Abnormality of abdominal situs (HP:0011620)1.61389912
95Abdominal situs inversus (HP:0003363)1.61389912
96Drooling (HP:0002307)1.61228065
97Aganglionic megacolon (HP:0002251)1.61074519
98Hepatoblastoma (HP:0002884)1.60875350
99Embryonal neoplasm (HP:0002898)1.60250243
100Focal motor seizures (HP:0011153)1.60084703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.67792439
2ZAK3.06165701
3STK38L2.87800578
4BMPR1B2.72183742
5BUB12.59834515
6ACVR1B2.50741839
7WNK32.48994306
8TTK2.47258045
9PLK42.38752068
10NUAK12.33428860
11SRPK12.22050447
12TRIM282.20510243
13FRK2.18962274
14CDC72.18346036
15MKNK22.12550822
16MAP3K42.07165481
17BRSK21.97204950
18EIF2AK31.94778278
19NEK11.93847784
20MKNK11.88612197
21MAP4K21.84430653
22PLK31.73383041
23WEE11.56734178
24STK31.50242473
25BCR1.49406541
26TSSK61.49201965
27PLK11.48118240
28CDK191.47625123
29PNCK1.41666636
30VRK11.39959189
31TAF11.36842852
32CASK1.36660787
33BRD41.36458805
34TNIK1.36202292
35NEK21.33295425
36MST41.33039986
37TGFBR11.29505319
38LATS21.26743083
39CSNK1A1L1.24893091
40MAP2K71.20056309
41ERBB31.19132859
42PBK1.17998726
43CHEK21.15707785
44TAOK31.12750923
45INSRR1.11481196
46NLK1.11152010
47PLK21.09513212
48CSNK1G11.07234210
49ATR1.04680831
50VRK21.02656366
51MAPK130.99680354
52EPHA40.97961884
53CSNK1G30.93492089
54PRKD30.92038481
55MELK0.89648402
56ATM0.89459193
57PINK10.87126554
58BRSK10.86068028
59CSNK1G20.83658111
60STK390.79863516
61EIF2AK10.77304355
62AURKB0.71293941
63STK160.70695671
64CHEK10.70577810
65EIF2AK20.68695830
66ERBB40.67987834
67CDK80.66719664
68DYRK20.66614391
69CCNB10.65885980
70DYRK30.65495815
71CDK90.63836874
72RPS6KA40.61657666
73WNK40.54390072
74OXSR10.50179065
75BRAF0.47104639
76AURKA0.45137884
77STK240.44680942
78BCKDK0.44614665
79CDK30.43603809
80CDK70.43342713
81CDK10.42801369
82ADRBK20.41709273
83CSNK1D0.41516204
84NME10.41494997
85CDK20.40343744
86FLT30.40129632
87FGFR10.39602025
88PRKCE0.37867706
89CAMK1G0.37849248
90MARK10.37285082
91NEK90.35384622
92STK380.35126808
93FGFR20.32220832
94AKT30.31461927
95NTRK20.31104514
96TLK10.30881732
97PASK0.29898841
98NEK60.28559727
99PRKCG0.28538751
100PRKCI0.28135174

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.39837119
2Homologous recombination_Homo sapiens_hsa034403.29041491
3Mismatch repair_Homo sapiens_hsa034303.25023640
4Basal transcription factors_Homo sapiens_hsa030223.07613996
5Fanconi anemia pathway_Homo sapiens_hsa034603.07218458
6DNA replication_Homo sapiens_hsa030302.72190447
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65309579
8Cell cycle_Homo sapiens_hsa041102.58269455
9RNA polymerase_Homo sapiens_hsa030202.38406283
10RNA degradation_Homo sapiens_hsa030182.33132056
11RNA transport_Homo sapiens_hsa030132.31082661
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30395118
13Nucleotide excision repair_Homo sapiens_hsa034202.13213226
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02799873
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94923084
16Phototransduction_Homo sapiens_hsa047441.90492167
17Spliceosome_Homo sapiens_hsa030401.89275919
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89069270
19Base excision repair_Homo sapiens_hsa034101.88399369
20Steroid biosynthesis_Homo sapiens_hsa001001.84558677
21One carbon pool by folate_Homo sapiens_hsa006701.83485387
22Protein export_Homo sapiens_hsa030601.82867969
23Propanoate metabolism_Homo sapiens_hsa006401.78455392
24Proteasome_Homo sapiens_hsa030501.68785795
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.66322993
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62344402
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59087202
28Oocyte meiosis_Homo sapiens_hsa041141.52861177
29Nicotine addiction_Homo sapiens_hsa050331.48711721
30Butanoate metabolism_Homo sapiens_hsa006501.44643736
31Selenocompound metabolism_Homo sapiens_hsa004501.41042811
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31154862
33mRNA surveillance pathway_Homo sapiens_hsa030151.30704630
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29284723
35Pyrimidine metabolism_Homo sapiens_hsa002401.28463969
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25089484
37p53 signaling pathway_Homo sapiens_hsa041151.23894406
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21925518
39Purine metabolism_Homo sapiens_hsa002301.15774985
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14710145
41Taste transduction_Homo sapiens_hsa047421.03373321
42Pyruvate metabolism_Homo sapiens_hsa006200.94623785
43TGF-beta signaling pathway_Homo sapiens_hsa043500.91357637
44Dorso-ventral axis formation_Homo sapiens_hsa043200.90477329
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89478137
46Fatty acid elongation_Homo sapiens_hsa000620.87589090
47Basal cell carcinoma_Homo sapiens_hsa052170.87071526
48Huntingtons disease_Homo sapiens_hsa050160.83639494
49Hedgehog signaling pathway_Homo sapiens_hsa043400.82193286
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78862737
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77875430
52Caffeine metabolism_Homo sapiens_hsa002320.77740406
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74139715
54Hippo signaling pathway_Homo sapiens_hsa043900.72616099
55Lysine degradation_Homo sapiens_hsa003100.72229915
56Olfactory transduction_Homo sapiens_hsa047400.71797087
57Parkinsons disease_Homo sapiens_hsa050120.70388377
58N-Glycan biosynthesis_Homo sapiens_hsa005100.68267855
59Oxidative phosphorylation_Homo sapiens_hsa001900.67247725
60Tryptophan metabolism_Homo sapiens_hsa003800.64229172
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63595624
62Wnt signaling pathway_Homo sapiens_hsa043100.57518024
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55223218
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54871445
65Linoleic acid metabolism_Homo sapiens_hsa005910.52529565
66Circadian rhythm_Homo sapiens_hsa047100.52381292
67Metabolic pathways_Homo sapiens_hsa011000.50779970
68Fatty acid metabolism_Homo sapiens_hsa012120.50704286
69Peroxisome_Homo sapiens_hsa041460.50287067
70Vitamin digestion and absorption_Homo sapiens_hsa049770.49471767
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48000738
72Ether lipid metabolism_Homo sapiens_hsa005650.47187388
73Folate biosynthesis_Homo sapiens_hsa007900.46870799
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45338313
75beta-Alanine metabolism_Homo sapiens_hsa004100.44091635
76Morphine addiction_Homo sapiens_hsa050320.43889710
77Sphingolipid metabolism_Homo sapiens_hsa006000.43068374
78Ribosome_Homo sapiens_hsa030100.41886260
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.41313307
80Alcoholism_Homo sapiens_hsa050340.41055861
81Nitrogen metabolism_Homo sapiens_hsa009100.40943697
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39640727
83Fatty acid degradation_Homo sapiens_hsa000710.39400789
84GABAergic synapse_Homo sapiens_hsa047270.39346090
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34911441
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33078622
87Regulation of autophagy_Homo sapiens_hsa041400.31917113
88Glutathione metabolism_Homo sapiens_hsa004800.31589888
89Ovarian steroidogenesis_Homo sapiens_hsa049130.31339487
90Retinol metabolism_Homo sapiens_hsa008300.28599617
91Sulfur relay system_Homo sapiens_hsa041220.27674004
92Arginine and proline metabolism_Homo sapiens_hsa003300.25901275
93Serotonergic synapse_Homo sapiens_hsa047260.24932971
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24420319
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22864476
96Colorectal cancer_Homo sapiens_hsa052100.22218335
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22149217
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21795979
99Adherens junction_Homo sapiens_hsa045200.20521598
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18787556

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »