ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	3.96396787
2	cilium or flagellum-dependent cell motility (GO:0001539)	3.80577130
3	indole-containing compound catabolic process (GO:0042436)	3.74200371
4	indolalkylamine catabolic process (GO:0046218)	3.74200371
5	tryptophan catabolic process (GO:0006569)	3.74200371
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.70377170
7	establishment of protein localization to Golgi (GO:0072600)	3.68545818
8	indolalkylamine metabolic process (GO:0006586)	3.67923743
9	behavioral response to nicotine (GO:0035095)	3.52594813
10	L-fucose catabolic process (GO:0042355)	3.52483626
11	fucose catabolic process (GO:0019317)	3.52483626
12	L-fucose metabolic process (GO:0042354)	3.52483626
13	regulation of sarcomere organization (GO:0060297)	3.51086393
14	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.48715349
15	interkinetic nuclear migration (GO:0022027)	3.47277741
16	protein K11-linked deubiquitination (GO:0035871)	3.44638399
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.42969006
18	regulation of pigment cell differentiation (GO:0050932)	3.42748681
19	monoubiquitinated protein deubiquitination (GO:0035520)	3.35413153
20	tryptophan metabolic process (GO:0006568)	3.27903289
21	positive regulation of developmental pigmentation (GO:0048087)	3.19422096
22	negative regulation of neurotransmitter transport (GO:0051589)	3.19099843
23	detection of light stimulus involved in visual perception (GO:0050908)	3.19026122
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.19026122
25	phospholipid translocation (GO:0045332)	3.17015841
26	lipid translocation (GO:0034204)	3.17015841
27	reflex (GO:0060004)	3.13627930
28	kynurenine metabolic process (GO:0070189)	3.12442471
29	negative regulation of mast cell activation (GO:0033004)	3.11232618
30	retinal cone cell development (GO:0046549)	3.09630856
31	serotonin metabolic process (GO:0042428)	3.09510883
32	photoreceptor cell maintenance (GO:0045494)	3.08465117
33	protein K48-linked deubiquitination (GO:0071108)	3.06972663
34	cellular ketone body metabolic process (GO:0046950)	3.06688552
35	indole-containing compound metabolic process (GO:0042430)	2.99943683
36	response to pheromone (GO:0019236)	2.98765920
37	signal peptide processing (GO:0006465)	2.97613278
38	primary amino compound metabolic process (GO:1901160)	2.97589546
39	cAMP catabolic process (GO:0006198)	2.96225146
40	regulation of establishment of cell polarity (GO:2000114)	2.96215166
41	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.95164352
42	regulation of translation, ncRNA-mediated (GO:0045974)	2.95164352
43	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.95164352
44	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.92261015
45	neuronal action potential (GO:0019228)	2.91005772
46	protein targeting to Golgi (GO:0000042)	2.90256158
47	gamma-aminobutyric acid transport (GO:0015812)	2.89719168
48	ketone body metabolic process (GO:1902224)	2.88643647
49	behavioral response to ethanol (GO:0048149)	2.82881861
50	cyclic nucleotide catabolic process (GO:0009214)	2.79600956
51	presynaptic membrane assembly (GO:0097105)	2.76744985
52	central nervous system neuron axonogenesis (GO:0021955)	2.76584271
53	membrane depolarization during action potential (GO:0086010)	2.76255933
54	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.76095476
55	cellular response to sterol (GO:0036315)	2.72479266
56	axoneme assembly (GO:0035082)	2.70301752
57	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.69777969
58	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.66755361
59	inner ear receptor stereocilium organization (GO:0060122)	2.64391043
60	regulation of hippo signaling (GO:0035330)	2.64045632
61	neuronal action potential propagation (GO:0019227)	2.62621161
62	protein K63-linked deubiquitination (GO:0070536)	2.59948004
63	negative regulation of neurotransmitter secretion (GO:0046929)	2.59706214
64	cilium organization (GO:0044782)	2.58297510
65	epithelial cilium movement (GO:0003351)	2.56453773
66	pyrimidine nucleobase catabolic process (GO:0006208)	2.53932177
67	cilium assembly (GO:0042384)	2.53369481
68	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.52547407
69	cilium movement (GO:0003341)	2.52371406
70	central nervous system projection neuron axonogenesis (GO:0021952)	2.50967454
71	presynaptic membrane organization (GO:0097090)	2.50700884
72	benzene-containing compound metabolic process (GO:0042537)	2.50654519
73	cellular response to ethanol (GO:0071361)	2.50008106
74	cilium morphogenesis (GO:0060271)	2.49724801
75	nucleus localization (GO:0051647)	2.48624597
76	auditory receptor cell stereocilium organization (GO:0060088)	2.46708233
77	regulation of action potential (GO:0098900)	2.45583774
78	sulfation (GO:0051923)	2.45096210
79	proline transport (GO:0015824)	2.44921640
80	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.42556998
81	startle response (GO:0001964)	2.42263878
82	neuron cell-cell adhesion (GO:0007158)	2.42231027
83	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.39568420
84	microtubule anchoring (GO:0034453)	2.38692249
85	glycosphingolipid biosynthetic process (GO:0006688)	2.37076547
86	cerebellar Purkinje cell differentiation (GO:0021702)	2.37063892
87	protein targeting to vacuole (GO:0006623)	2.36091239
88	protein targeting to lysosome (GO:0006622)	2.36091239
89	establishment of protein localization to vacuole (GO:0072666)	2.36091239
90	neurotransmitter-gated ion channel clustering (GO:0072578)	2.35659157
91	glutamate receptor signaling pathway (GO:0007215)	2.34041174
92	regulation of gene silencing by miRNA (GO:0060964)	2.32863906
93	regulation of gene silencing by RNA (GO:0060966)	2.32863906
94	regulation of posttranscriptional gene silencing (GO:0060147)	2.32863906
95	limb development (GO:0060173)	2.32850301
96	appendage development (GO:0048736)	2.32850301
97	tachykinin receptor signaling pathway (GO:0007217)	2.32566604
98	thyroid hormone metabolic process (GO:0042403)	2.32145703
99	transmission of nerve impulse (GO:0019226)	2.31178525
100	snRNA transcription (GO:0009301)	2.31157462

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.65300409
2	IGF1R_20145208_ChIP-Seq_DFB_Human	2.98519405
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.82387940
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.73011887
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71159438
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.67834864
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.66647832
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58358500
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56829376
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.53923266
11	VDR_22108803_ChIP-Seq_LS180_Human	2.49969279
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28568330
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.17726110
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.16859691
15	* P300_19829295_ChIP-Seq_ESCs_Human	2.10355942
16	FUS_26573619_Chip-Seq_HEK293_Human	2.08853960
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04264284
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.96128471
19	EWS_26573619_Chip-Seq_HEK293_Human	1.95367833
20	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.94137202
21	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.93995372
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.92777527
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.91625514
24	STAT3_23295773_ChIP-Seq_U87_Human	1.86640068
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83061594
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.69579662
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.69571417
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67860297
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.67675689
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66556663
31	TCF4_23295773_ChIP-Seq_U87_Human	1.66431830
32	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63588213
33	AR_25329375_ChIP-Seq_VCAP_Human	1.60475543
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.60281338
35	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58828475
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57783243
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.57126363
38	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.56313384
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.55146158
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52027454
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49819125
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49508574
43	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.47868968
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.47448172
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47448172
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47265204
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.47265204
48	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.43218564
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.41138059
50	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.38881832
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38656882
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36822627
53	TP53_16413492_ChIP-PET_HCT116_Human	1.36610894
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36340891
55	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.35553410
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33741543
57	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.31879870
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30484966
59	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.30052058
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28829267
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28654006
62	* TCF4_22108803_ChIP-Seq_LS180_Human	1.27979522
63	DROSHA_22980978_ChIP-Seq_HELA_Human	1.26452625
64	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.26382394
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25184762
66	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.24480632
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.24062279
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21101065
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20311405
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19907287
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19730180
72	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.19634116
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19368684
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18353922
75	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.17417004
76	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.17417004
77	AHR_22903824_ChIP-Seq_MCF-7_Human	1.16949363
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16345227
79	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.16006888
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15080365
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.14971116
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13381853
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.12804802
84	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.11323987
85	KDM2B_26808549_Chip-Seq_REH_Human	1.10965663
86	CDX2_22108803_ChIP-Seq_LS180_Human	1.10234150
87	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08726300
88	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.08599840
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07937345
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07269647
91	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06650478
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06463676
93	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06163686
94	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06163686
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06158685
96	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.05004674
97	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03117062
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.02115253
99	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00005628
100	TP53_18474530_ChIP-ChIP_U2OS_Human	0.99815295

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.81474972
2	MP0003195_calcinosis	2.43008127
3	MP0008057_abnormal_DNA_replication	2.35923975
4	MP0005551_abnormal_eye_electrophysiolog	2.35577044
5	MP0008877_abnormal_DNA_methylation	2.33596728
6	MP0009046_muscle_twitch	2.31900568
7	MP0002102_abnormal_ear_morphology	2.26742546
8	MP0003787_abnormal_imprinting	2.25905255
9	MP0004043_abnormal_pH_regulation	2.21971553
10	MP0001968_abnormal_touch/_nociception	2.18248147
11	MP0001501_abnormal_sleep_pattern	2.14766993
12	MP0009745_abnormal_behavioral_response	2.13348520
13	MP0003646_muscle_fatigue	2.10951906
14	MP0001486_abnormal_startle_reflex	1.94901531
15	MP0006276_abnormal_autonomic_nervous	1.90742137
16	MP0004145_abnormal_muscle_electrophysio	1.83417522
17	MP0002272_abnormal_nervous_system	1.81622378
18	MP0003880_abnormal_central_pattern	1.81262164
19	MP0000427_abnormal_hair_cycle	1.73593033
20	MP0005253_abnormal_eye_physiology	1.70238571
21	MP0010386_abnormal_urinary_bladder	1.68755250
22	MP0004147_increased_porphyrin_level	1.68668805
23	MP0002638_abnormal_pupillary_reflex	1.68216664
24	MP0002735_abnormal_chemical_nociception	1.67777171
25	MP0002837_dystrophic_cardiac_calcinosis	1.66926189
26	MP0002736_abnormal_nociception_after	1.66007095
27	MP0004924_abnormal_behavior	1.65938989
28	MP0005386_behavior/neurological_phenoty	1.65938989
29	MP0002064_seizures	1.64975185
30	MP0004885_abnormal_endolymph	1.64511495
31	MP0005646_abnormal_pituitary_gland	1.61473171
32	MP0003635_abnormal_synaptic_transmissio	1.60474183
33	MP0005174_abnormal_tail_pigmentation	1.57703412
34	MP0004215_abnormal_myocardial_fiber	1.55762006
35	MP0000383_abnormal_hair_follicle	1.50924810
36	MP0002822_catalepsy	1.50880648
37	MP0004142_abnormal_muscle_tone	1.47044633
38	MP0001984_abnormal_olfaction	1.46594692
39	MP0002572_abnormal_emotion/affect_behav	1.45881976
40	MP0006072_abnormal_retinal_apoptosis	1.44585154
41	MP0001485_abnormal_pinna_reflex	1.43730464
42	MP0004484_altered_response_of	1.39038481
43	MP0002067_abnormal_sensory_capabilities	1.36471349
44	MP0002063_abnormal_learning/memory/cond	1.35882261
45	MP0001986_abnormal_taste_sensitivity	1.34806585
46	MP0008961_abnormal_basal_metabolism	1.33080024
47	MP0005645_abnormal_hypothalamus_physiol	1.27757784
48	MP0002557_abnormal_social/conspecific_i	1.24747028
49	MP0004130_abnormal_muscle_cell	1.21839376
50	MP0003633_abnormal_nervous_system	1.20081202
51	MP0005167_abnormal_blood-brain_barrier	1.19789693
52	MP0000778_abnormal_nervous_system	1.18118145
53	MP0001970_abnormal_pain_threshold	1.16411647
54	MP0002876_abnormal_thyroid_physiology	1.16307552
55	MP0005187_abnormal_penis_morphology	1.16282992
56	MP0000631_abnormal_neuroendocrine_gland	1.16141764
57	MP0008872_abnormal_physiological_respon	1.15187888
58	MP0003890_abnormal_embryonic-extraembry	1.10907704
59	MP0002734_abnormal_mechanical_nocicepti	1.09932856
60	MP0002928_abnormal_bile_duct	1.08235859
61	MP0002229_neurodegeneration	1.05186443
62	MP0000230_abnormal_systemic_arterial	1.02795458
63	MP0003045_fibrosis	1.01209121
64	MP0004270_analgesia	0.99602493
65	MP0002733_abnormal_thermal_nociception	0.97050385
66	MP0002234_abnormal_pharynx_morphology	0.95754129
67	MP0003136_yellow_coat_color	0.94815839
68	MP0002095_abnormal_skin_pigmentation	0.94789146
69	MP0002160_abnormal_reproductive_system	0.94253023
70	MP0004085_abnormal_heartbeat	0.92728988
71	MP0003252_abnormal_bile_duct	0.92480018
72	MP0003631_nervous_system_phenotype	0.90402147
73	MP0002184_abnormal_innervation	0.88413027
74	MP0008995_early_reproductive_senescence	0.87270147
75	MP0002138_abnormal_hepatobiliary_system	0.87258560
76	MP0000538_abnormal_urinary_bladder	0.87183689
77	MP0002882_abnormal_neuron_morphology	0.87103788
78	MP0004084_abnormal_cardiac_muscle	0.86516628
79	MP0001188_hyperpigmentation	0.86220925
80	MP0004742_abnormal_vestibular_system	0.85606032
81	MP0004133_heterotaxia	0.84511805
82	MP0002752_abnormal_somatic_nervous	0.83946023
83	MP0003868_abnormal_feces_composition	0.83898764
84	MP0002938_white_spotting	0.83173116
85	MP0005195_abnormal_posterior_eye	0.83099723
86	MP0005171_absent_coat_pigmentation	0.82553068
87	MP0001664_abnormal_digestion	0.81740014
88	MP0008775_abnormal_heart_ventricle	0.81199615
89	MP0006054_spinal_hemorrhage	0.80539450
90	MP0010678_abnormal_skin_adnexa	0.79191169
91	MP0002009_preneoplasia	0.79186729
92	MP0002168_other_aberrant_phenotype	0.78868972
93	MP0001963_abnormal_hearing_physiology	0.77728433
94	MP0003137_abnormal_impulse_conducting	0.76840550
95	MP0001440_abnormal_grooming_behavior	0.76153087
96	MP0004859_abnormal_synaptic_plasticity	0.74618486
97	MP0009780_abnormal_chondrocyte_physiolo	0.74576400
98	MP0004036_abnormal_muscle_relaxation	0.73948065
99	MP0005389_reproductive_system_phenotype	0.73398960
100	MP0000015_abnormal_ear_pigmentation	0.73274882

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.75800452
2	Pancreatic cysts (HP:0001737)	4.37816771
3	Pancreatic fibrosis (HP:0100732)	4.09929936
4	Genetic anticipation (HP:0003743)	3.92623660
5	Gaze-evoked nystagmus (HP:0000640)	3.86769437
6	True hermaphroditism (HP:0010459)	3.84516160
7	Febrile seizures (HP:0002373)	3.62165396
8	Progressive cerebellar ataxia (HP:0002073)	3.57521311
9	Nephronophthisis (HP:0000090)	3.52318987
10	Protruding tongue (HP:0010808)	3.45569990
11	Abnormality of the renal cortex (HP:0011035)	3.42453636
12	Molar tooth sign on MRI (HP:0002419)	3.39777856
13	Abnormality of midbrain morphology (HP:0002418)	3.39777856
14	Congenital stationary night blindness (HP:0007642)	3.35775434
15	Abnormality of the renal medulla (HP:0100957)	3.32307754
16	Chronic hepatic failure (HP:0100626)	3.24661460
17	Medial flaring of the eyebrow (HP:0010747)	3.07483692
18	Absent speech (HP:0001344)	2.98803187
19	Broad-based gait (HP:0002136)	2.96899107
20	Focal seizures (HP:0007359)	2.89683568
21	Fair hair (HP:0002286)	2.87644222
22	Cystic liver disease (HP:0006706)	2.86873514
23	Clumsiness (HP:0002312)	2.80349455
24	Widely spaced teeth (HP:0000687)	2.74706174
25	Attenuation of retinal blood vessels (HP:0007843)	2.72709544
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.67988397
27	Abolished electroretinogram (ERG) (HP:0000550)	2.65511873
28	Inability to walk (HP:0002540)	2.62819852
29	Focal motor seizures (HP:0011153)	2.57108748
30	Gait imbalance (HP:0002141)	2.56338174
31	Renal cortical cysts (HP:0000803)	2.55546812
32	Tubular atrophy (HP:0000092)	2.49978482
33	Congenital primary aphakia (HP:0007707)	2.46042917
34	Decreased circulating renin level (HP:0003351)	2.39551724
35	Dialeptic seizures (HP:0011146)	2.38684989
36	Drooling (HP:0002307)	2.36814755
37	Progressive inability to walk (HP:0002505)	2.36686292
38	Genital tract atresia (HP:0001827)	2.32775247
39	Abnormal drinking behavior (HP:0030082)	2.32337738
40	Polydipsia (HP:0001959)	2.32337738
41	Stomach cancer (HP:0012126)	2.31867115
42	Nephrogenic diabetes insipidus (HP:0009806)	2.31537383
43	Congenital hepatic fibrosis (HP:0002612)	2.29548329
44	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.28948462
45	Abnormality of alanine metabolism (HP:0010916)	2.28948462
46	Hyperalaninemia (HP:0003348)	2.28948462
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.27824389
48	Congenital sensorineural hearing impairment (HP:0008527)	2.26806175
49	Generalized hypopigmentation of hair (HP:0011358)	2.26784638
50	Hemiparesis (HP:0001269)	2.25029627
51	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20617063
52	Absent/shortened dynein arms (HP:0200106)	2.20617063
53	Cerebellar dysplasia (HP:0007033)	2.18741140
54	Vaginal atresia (HP:0000148)	2.16681393
55	Excessive salivation (HP:0003781)	2.11639398
56	Atonic seizures (HP:0010819)	2.11204253
57	Hypothermia (HP:0002045)	2.10457164
58	Type II lissencephaly (HP:0007260)	2.09287576
59	Abnormality of the ischium (HP:0003174)	2.09101171
60	Large for gestational age (HP:0001520)	2.09058960
61	Bile duct proliferation (HP:0001408)	2.09046712
62	Abnormal biliary tract physiology (HP:0012439)	2.09046712
63	Hypoplastic ischia (HP:0003175)	2.07768910
64	Furrowed tongue (HP:0000221)	2.07008693
65	Abnormality of macular pigmentation (HP:0008002)	2.00991040
66	Chorioretinal atrophy (HP:0000533)	1.99926785
67	Cupped ear (HP:0000378)	1.99675525
68	Postaxial foot polydactyly (HP:0001830)	1.97923068
69	Poor coordination (HP:0002370)	1.97211393
70	Absence seizures (HP:0002121)	1.96992696
71	Bony spicule pigmentary retinopathy (HP:0007737)	1.96898466
72	Keratoconus (HP:0000563)	1.96715607
73	Increased corneal curvature (HP:0100692)	1.96715607
74	Tubulointerstitial nephritis (HP:0001970)	1.96087761
75	Male pseudohermaphroditism (HP:0000037)	1.94522359
76	Decreased central vision (HP:0007663)	1.93618110
77	Neoplasm of the adrenal cortex (HP:0100641)	1.93159836
78	Abnormal rod and cone electroretinograms (HP:0008323)	1.91173367
79	Abnormal ciliary motility (HP:0012262)	1.89113575
80	Central scotoma (HP:0000603)	1.87393136
81	Tubulointerstitial abnormality (HP:0001969)	1.85791650
82	Intestinal atresia (HP:0011100)	1.85404975
83	Thyroiditis (HP:0100646)	1.84175775
84	Short foot (HP:0001773)	1.83033383
85	Epileptic encephalopathy (HP:0200134)	1.80855082
86	Polyuria (HP:0000103)	1.80713808
87	Sclerocornea (HP:0000647)	1.80643274
88	Exotropia (HP:0000577)	1.80038463
89	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.79419677
90	Lissencephaly (HP:0001339)	1.79062831
91	Thyroid-stimulating hormone excess (HP:0002925)	1.79013138
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.75555464
93	Postaxial hand polydactyly (HP:0001162)	1.75142302
94	Anencephaly (HP:0002323)	1.74561241
95	Hypoplastic labia majora (HP:0000059)	1.74238280
96	Hypoplastic iliac wings (HP:0002866)	1.73994950
97	Urinary bladder sphincter dysfunction (HP:0002839)	1.72965919
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.72057507
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.72057507
100	Tented upper lip vermilion (HP:0010804)	1.68648703

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.92245272
2	BMPR1B	2.89608900
3	ACVR1B	2.87230702
4	CASK	2.57345794
5	WNK3	2.28190294
6	MAP4K2	2.13033528
7	MAPK13	2.08330774
8	ADRBK2	1.99476515
9	TAOK3	1.90987806
10	PINK1	1.89843592
11	MAP3K4	1.81122923
12	AKT3	1.76082633
13	NUAK1	1.66951573
14	NTRK3	1.64636036
15	GRK1	1.59097935
16	INSRR	1.50716273
17	ZAK	1.50639899
18	STK38L	1.43701883
19	MARK1	1.40028695
20	MKNK2	1.39096872
21	OXSR1	1.38452727
22	PIK3CG	1.33353149
23	CAMKK2	1.31915002
24	SGK2	1.31811905
25	PAK3	1.22710854
26	LATS1	1.20960644
27	STK39	1.15720173
28	TGFBR1	1.14839724
29	DAPK2	1.14010379
30	ERBB3	1.11315576
31	OBSCN	1.10119630
32	BCKDK	1.06670434
33	TEC	1.05875842
34	TIE1	1.03210727
35	FGFR2	1.01516358
36	EPHA3	0.97006935
37	ADRBK1	0.95108020
38	PIK3CA	0.94432172
39	PRKCE	0.88597139
40	BCR	0.88204194
41	SGK494	0.87291692
42	SGK223	0.87291692
43	EIF2AK3	0.81826335
44	NLK	0.81566377
45	PTK2B	0.81056798
46	MAP2K7	0.80829623
47	TNIK	0.80248087
48	TXK	0.76516201
49	CSNK1G1	0.74821955
50	MKNK1	0.74084799
51	CSNK1G2	0.73018792
52	CSNK1A1L	0.73013652
53	TRPM7	0.72693113
54	FER	0.70481973
55	NTRK2	0.70156735
56	WNK4	0.68266591
57	CAMK1G	0.67227720
58	CAMK4	0.65830488
59	PRKAA2	0.65495181
60	CAMK2A	0.63237607
61	TLK1	0.62156585
62	EPHA4	0.61246916
63	STK3	0.60431709
64	MAP3K7	0.59772935
65	KIT	0.59284901
66	TRIM28	0.58138364
67	CDK3	0.56360737
68	CSNK1G3	0.53885394
69	PLK2	0.53755335
70	STK11	0.52469970
71	PRKCG	0.52220904
72	CAMK1D	0.51854044
73	CAMK1	0.50849064
74	BRSK2	0.50252515
75	SGK3	0.48259383
76	MAP2K6	0.48185426
77	PKN1	0.46710662
78	IRAK1	0.45463595
79	PNCK	0.44887149
80	PRKAA1	0.44662660
81	DYRK1A	0.44249625
82	MARK3	0.43911235
83	PRKG1	0.43141991
84	CSNK1D	0.42145634
85	PHKG2	0.42071206
86	PHKG1	0.42071206
87	STK38	0.41847191
88	SGK1	0.39757243
89	TNK2	0.38979255
90	SIK2	0.38944762
91	MAP2K4	0.37788499
92	PRKACA	0.36299998
93	MUSK	0.34737253
94	MAPK7	0.33770753
95	ITK	0.29965301
96	DYRK3	0.29760349
97	RPS6KA5	0.29659961
98	RPS6KA3	0.29482113
99	RPS6KB1	0.29373731
100	ABL1	0.29300726

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.58766569
2	Butanoate metabolism_Homo sapiens_hsa00650	2.38667407
3	Phototransduction_Homo sapiens_hsa04744	2.35238991
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15775530
5	ABC transporters_Homo sapiens_hsa02010	2.09192751
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99627957
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97504773
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97190881
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.95133770
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.84502386
11	Circadian entrainment_Homo sapiens_hsa04713	1.84399296
12	Morphine addiction_Homo sapiens_hsa05032	1.84142902
13	Taste transduction_Homo sapiens_hsa04742	1.80606331
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.80432403
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75491170
16	Glutamatergic synapse_Homo sapiens_hsa04724	1.72081307
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.69261196
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.66993370
19	Olfactory transduction_Homo sapiens_hsa04740	1.66311827
20	Serotonergic synapse_Homo sapiens_hsa04726	1.56232503
21	Salivary secretion_Homo sapiens_hsa04970	1.56082530
22	Propanoate metabolism_Homo sapiens_hsa00640	1.55061875
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.54706517
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.53204259
25	GABAergic synapse_Homo sapiens_hsa04727	1.51307000
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.49180202
27	Insulin secretion_Homo sapiens_hsa04911	1.46720039
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45041523
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.43054958
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.42260378
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.36484222
32	Circadian rhythm_Homo sapiens_hsa04710	1.32887412
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.32598133
34	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.31680953
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30420573
36	Renin secretion_Homo sapiens_hsa04924	1.29229091
37	Long-term depression_Homo sapiens_hsa04730	1.23179124
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.16959435
39	Dopaminergic synapse_Homo sapiens_hsa04728	1.16378967
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.12895906
41	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.12793531
42	Retinol metabolism_Homo sapiens_hsa00830	1.12097395
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.11828128
44	Cholinergic synapse_Homo sapiens_hsa04725	1.06833533
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.05051338
46	Caffeine metabolism_Homo sapiens_hsa00232	1.04468882
47	Histidine metabolism_Homo sapiens_hsa00340	1.03973291
48	Gastric acid secretion_Homo sapiens_hsa04971	1.03584495
49	Amphetamine addiction_Homo sapiens_hsa05031	1.03297385
50	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01737268
51	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.01000049
52	cAMP signaling pathway_Homo sapiens_hsa04024	0.97847185
53	Cocaine addiction_Homo sapiens_hsa05030	0.92733099
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90125717
55	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.88231447
56	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.86347046
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83582363
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83159025
59	Pancreatic secretion_Homo sapiens_hsa04972	0.82002832
60	Peroxisome_Homo sapiens_hsa04146	0.80815369
61	Regulation of autophagy_Homo sapiens_hsa04140	0.79828873
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77901922
63	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.75635690
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74654053
65	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.74453968
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.73237238
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72282274
68	Basal transcription factors_Homo sapiens_hsa03022	0.71608037
69	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68390515
70	Platelet activation_Homo sapiens_hsa04611	0.67483136
71	Lysine degradation_Homo sapiens_hsa00310	0.64973658
72	Fatty acid degradation_Homo sapiens_hsa00071	0.63147516
73	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.61820889
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56499599
75	Type II diabetes mellitus_Homo sapiens_hsa04930	0.54933781
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54493613
77	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52100892
78	Ras signaling pathway_Homo sapiens_hsa04014	0.52002562
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.51034321
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.50305975
81	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.49146752
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49006503
83	Homologous recombination_Homo sapiens_hsa03440	0.46055906
84	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.45605501
85	Axon guidance_Homo sapiens_hsa04360	0.42519333
86	Bile secretion_Homo sapiens_hsa04976	0.41842792
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.39758980
88	Long-term potentiation_Homo sapiens_hsa04720	0.39262357
89	Melanoma_Homo sapiens_hsa05218	0.36966787
90	MAPK signaling pathway_Homo sapiens_hsa04010	0.36653066
91	RNA degradation_Homo sapiens_hsa03018	0.36312991
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.34690214
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.34512835
94	Estrogen signaling pathway_Homo sapiens_hsa04915	0.34251589
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.34066700
96	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.33518710
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.30843279
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.30641655
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30377746
100	Choline metabolism in cancer_Homo sapiens_hsa05231	0.30202588

ZNF280D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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