ZNF281

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.93567394
2CENP-A containing nucleosome assembly (GO:0034080)4.84938456
3mitotic sister chromatid cohesion (GO:0007064)4.62432264
4mitotic metaphase plate congression (GO:0007080)4.57131874
5nuclear pore complex assembly (GO:0051292)4.55350386
6protein localization to kinetochore (GO:0034501)4.50263221
7regulation of helicase activity (GO:0051095)4.36751615
8nuclear pore organization (GO:0006999)4.34242243
9establishment of integrated proviral latency (GO:0075713)4.31588798
10histone exchange (GO:0043486)4.28175255
11pre-miRNA processing (GO:0031054)4.15897734
12negative regulation of mitotic sister chromatid separation (GO:2000816)4.14562174
13negative regulation of sister chromatid segregation (GO:0033046)4.14562174
14negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.14562174
15negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.14562174
16negative regulation of mitotic sister chromatid segregation (GO:0033048)4.14562174
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.12718139
18regulation of mitotic spindle checkpoint (GO:1903504)4.12718139
19DNA replication-independent nucleosome organization (GO:0034724)4.10331967
20DNA replication-independent nucleosome assembly (GO:0006336)4.10331967
21negative regulation of chromosome segregation (GO:0051985)4.05736844
22metaphase plate congression (GO:0051310)4.02759784
23protein localization to chromosome, centromeric region (GO:0071459)3.95369426
24regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.87952426
25regulation of mitotic metaphase/anaphase transition (GO:0030071)3.87952426
26spindle checkpoint (GO:0031577)3.87908659
27mitotic spindle checkpoint (GO:0071174)3.86883506
28DNA replication checkpoint (GO:0000076)3.85143881
29regulation of centriole replication (GO:0046599)3.79765345
30regulation of mitotic sister chromatid separation (GO:0010965)3.76989389
31regulation of mitotic sister chromatid segregation (GO:0033047)3.76989389
32regulation of sister chromatid segregation (GO:0033045)3.76989389
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.70185057
34regulation of histone H3-K9 methylation (GO:0051570)3.69895795
35regulation of gene silencing by RNA (GO:0060966)3.68598444
36regulation of posttranscriptional gene silencing (GO:0060147)3.68598444
37regulation of gene silencing by miRNA (GO:0060964)3.68598444
38mitotic spindle assembly checkpoint (GO:0007094)3.66832592
39synapsis (GO:0007129)3.59688321
40spindle assembly checkpoint (GO:0071173)3.59506993
41regulation of chromosome segregation (GO:0051983)3.54969822
42regulation of meiosis I (GO:0060631)3.51429287
43kinetochore organization (GO:0051383)3.47324003
44mitotic G2/M transition checkpoint (GO:0044818)3.45704266
45negative regulation of translation, ncRNA-mediated (GO:0040033)3.45509426
46regulation of translation, ncRNA-mediated (GO:0045974)3.45509426
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.45509426
48establishment of chromosome localization (GO:0051303)3.40689824
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.38494997
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.38494997
51DNA double-strand break processing (GO:0000729)3.37235992
52DNA strand elongation involved in DNA replication (GO:0006271)3.34811925
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34493525
54regulation of DNA endoreduplication (GO:0032875)3.33885216
55negative regulation of DNA recombination (GO:0045910)3.31269736
56negative regulation of mitosis (GO:0045839)3.30325689
57ATP-dependent chromatin remodeling (GO:0043044)3.28518934
58regulation of nuclear cell cycle DNA replication (GO:0033262)3.26684210
59ribosome assembly (GO:0042255)3.25061153
60DNA strand elongation (GO:0022616)3.24411089
61pore complex assembly (GO:0046931)3.23636075
62paraxial mesoderm development (GO:0048339)3.22192660
63DNA replication-dependent nucleosome organization (GO:0034723)3.21270120
64DNA replication-dependent nucleosome assembly (GO:0006335)3.21270120
65attachment of spindle microtubules to kinetochore (GO:0008608)3.19379716
66sister chromatid segregation (GO:0000819)3.18265509
67regulation of DNA methylation (GO:0044030)3.16303118
68mitotic sister chromatid segregation (GO:0000070)3.16164663
69IMP biosynthetic process (GO:0006188)3.14270892
70histone mRNA metabolic process (GO:0008334)3.11132187
71establishment of viral latency (GO:0019043)3.11007397
72protein localization to chromosome (GO:0034502)3.10031998
73DNA synthesis involved in DNA repair (GO:0000731)3.08133309
74DNA damage response, detection of DNA damage (GO:0042769)3.07417383
75mitotic nuclear envelope disassembly (GO:0007077)3.06309827
76response to X-ray (GO:0010165)3.05751729
77sister chromatid cohesion (GO:0007062)3.05671893
78heterochromatin organization (GO:0070828)3.05244707
79kinetochore assembly (GO:0051382)3.03547181
80protein complex localization (GO:0031503)3.03332663
81telomere maintenance via telomerase (GO:0007004)3.03045367
82negative regulation of DNA repair (GO:0045738)3.02581201
83purine nucleobase biosynthetic process (GO:0009113)3.02105691
84negative regulation of nuclear division (GO:0051784)3.01442499
85double-strand break repair via nonhomologous end joining (GO:0006303)2.98289444
86non-recombinational repair (GO:0000726)2.98289444
87mitotic chromosome condensation (GO:0007076)2.97411092
88positive regulation of chromosome segregation (GO:0051984)2.96340104
89anterior/posterior axis specification, embryo (GO:0008595)2.95198248
90negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.94081337
91regulation of transcription from RNA polymerase I promoter (GO:0006356)2.93942037
92nuclear envelope disassembly (GO:0051081)2.91676162
93membrane disassembly (GO:0030397)2.91676162
94regulation of centrosome cycle (GO:0046605)2.90493782
95telomere maintenance via semi-conservative replication (GO:0032201)2.90234693
96chromatin assembly or disassembly (GO:0006333)2.88811060
97female gonad development (GO:0008585)2.88754944
98cellular protein complex localization (GO:0034629)2.88549485
99DNA ligation (GO:0006266)2.87121059
100positive regulation of SMAD protein import into nucleus (GO:0060391)2.85415808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.78252082
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06678524
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.89401598
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.72836776
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46812750
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00953274
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.96952084
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.88922180
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.78457653
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.74974450
11ELK1_19687146_ChIP-ChIP_HELA_Human2.61643129
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.57805613
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52326746
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47925208
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46000356
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.30337963
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.30337963
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.30337963
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19281452
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.15181883
21AR_21909140_ChIP-Seq_LNCAP_Human2.08347152
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06399539
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04761292
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.98097649
25EWS_26573619_Chip-Seq_HEK293_Human1.96390071
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.93926232
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.92311136
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89570889
29FUS_26573619_Chip-Seq_HEK293_Human1.86847121
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.83161928
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83043195
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77607812
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76681636
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74320345
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74318274
36* NANOG_16153702_ChIP-ChIP_HESCs_Human1.72160851
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69581478
38VDR_23849224_ChIP-Seq_CD4+_Human1.66856367
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66133750
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.61783087
41* SOX2_16153702_ChIP-ChIP_HESCs_Human1.60455983
42FOXP3_21729870_ChIP-Seq_TREG_Human1.56204382
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55489202
44ZNF274_21170338_ChIP-Seq_K562_Hela1.51436351
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51302617
46MYC_18940864_ChIP-ChIP_HL60_Human1.49479148
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48301791
48TTF2_22483619_ChIP-Seq_HELA_Human1.48192279
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47257018
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45503399
51DCP1A_22483619_ChIP-Seq_HELA_Human1.44805597
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41608673
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38937041
54SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37787187
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37531495
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35852682
57* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32572455
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32564580
59TAF15_26573619_Chip-Seq_HEK293_Human1.25998347
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25285066
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25215401
62P300_19829295_ChIP-Seq_ESCs_Human1.23749758
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22966275
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20082974
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18864562
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14955350
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13240713
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13125623
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.12531556
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.11609820
71IGF1R_20145208_ChIP-Seq_DFB_Human1.09247760
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08958045
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08602655
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.06301928
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06238543
76XRN2_22483619_ChIP-Seq_HELA_Human1.05596399
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02192294
78* GABP_19822575_ChIP-Seq_HepG2_Human1.00616620
79TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99556910
80IRF1_19129219_ChIP-ChIP_H3396_Human0.99367117
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99065374
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94668372
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94004203
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.93982513
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92860894
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91227766
87VDR_22108803_ChIP-Seq_LS180_Human0.87791200
88POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86518604
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82730108
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81886984
91TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80202400
92TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79196286
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.78069107
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76584411
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.76488043
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76232784
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75963782
98EGR1_19374776_ChIP-ChIP_THP-1_Human0.75915773
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75179155
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73437942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.31153482
2MP0008877_abnormal_DNA_methylation4.09817122
3MP0003941_abnormal_skin_development3.74951041
4MP0003693_abnormal_embryo_hatching3.71785192
5MP0003890_abnormal_embryonic-extraembry3.56870902
6MP0008058_abnormal_DNA_repair3.48741376
7MP0010094_abnormal_chromosome_stability3.43985828
8MP0004957_abnormal_blastocyst_morpholog3.43621777
9MP0006292_abnormal_olfactory_placode3.30699368
10MP0003111_abnormal_nucleus_morphology3.03081721
11MP0003077_abnormal_cell_cycle2.87971101
12MP0003718_maternal_effect2.59826701
13MP0008932_abnormal_embryonic_tissue2.43307877
14MP0008007_abnormal_cellular_replicative2.43274550
15MP0001293_anophthalmia2.35730439
16MP0002254_reproductive_system_inflammat1.97779639
17MP0010352_gastrointestinal_tract_polyps1.97426120
18MP0003937_abnormal_limbs/digits/tail_de1.95295035
19MP0003567_abnormal_fetal_cardiomyocyte1.95183766
20MP0001730_embryonic_growth_arrest1.76960702
21MP0000350_abnormal_cell_proliferation1.72868052
22MP0009672_abnormal_birth_weight1.72847257
23MP0003119_abnormal_digestive_system1.70166675
24MP0001188_hyperpigmentation1.70151455
25MP0002084_abnormal_developmental_patter1.63826112
26MP0003121_genomic_imprinting1.63068819
27MP0001286_abnormal_eye_development1.59285142
28MP0002697_abnormal_eye_size1.58800475
29MP0002085_abnormal_embryonic_tissue1.56698824
30MP0005380_embryogenesis_phenotype1.53354207
31MP0001672_abnormal_embryogenesis/_devel1.53354207
32MP0010030_abnormal_orbit_morphology1.48877852
33MP0009703_decreased_birth_body1.47545264
34MP0001697_abnormal_embryo_size1.46593492
35MP0008789_abnormal_olfactory_epithelium1.44483719
36MP0002233_abnormal_nose_morphology1.43842184
37MP0002210_abnormal_sex_determination1.36097217
38MP0009697_abnormal_copulation1.34005103
39MP0003984_embryonic_growth_retardation1.30783779
40MP0002088_abnormal_embryonic_growth/wei1.29458199
41MP0010307_abnormal_tumor_latency1.29136038
42MP0001529_abnormal_vocalization1.28178370
43MP0003786_premature_aging1.24997516
44MP0001929_abnormal_gametogenesis1.24804515
45MP0005499_abnormal_olfactory_system1.22680739
46MP0005394_taste/olfaction_phenotype1.22680739
47MP0004197_abnormal_fetal_growth/weight/1.22263840
48MP0000537_abnormal_urethra_morphology1.21583214
49MP0003787_abnormal_imprinting1.20614837
50MP0001145_abnormal_male_reproductive1.19038885
51MP0000049_abnormal_middle_ear1.16544744
52MP0002080_prenatal_lethality1.15313050
53MP0003755_abnormal_palate_morphology1.14934425
54MP0004133_heterotaxia1.14127599
55MP0000653_abnormal_sex_gland1.13568586
56MP0001177_atelectasis1.13399089
57MP0002111_abnormal_tail_morphology1.10771821
58MP0002751_abnormal_autonomic_nervous1.10565448
59MP0002102_abnormal_ear_morphology1.09112211
60MP0003861_abnormal_nervous_system1.04927386
61MP0002086_abnormal_extraembryonic_tissu1.02522879
62MP0001299_abnormal_eye_distance/1.02173221
63MP0006035_abnormal_mitochondrial_morpho1.01552979
64MP0003221_abnormal_cardiomyocyte_apopto0.99743292
65MP0008995_early_reproductive_senescence0.98497768
66MP0002938_white_spotting0.98228315
67MP0003935_abnormal_craniofacial_develop0.97453536
68MP0000428_abnormal_craniofacial_morphol0.96996480
69MP0000313_abnormal_cell_death0.96830163
70MP0003136_yellow_coat_color0.95220504
71MP0002092_abnormal_eye_morphology0.93967597
72MP0002160_abnormal_reproductive_system0.92190509
73MP0000432_abnormal_head_morphology0.91224175
74MP0003122_maternal_imprinting0.91182788
75MP0000647_abnormal_sebaceous_gland0.89307108
76MP0003315_abnormal_perineum_morphology0.88841838
77MP0001119_abnormal_female_reproductive0.87146584
78MP0002277_abnormal_respiratory_mucosa0.85704209
79MP0000631_abnormal_neuroendocrine_gland0.85631784
80MP0005395_other_phenotype0.85233479
81MP0000579_abnormal_nail_morphology0.84849089
82MP0009250_abnormal_appendicular_skeleto0.84449457
83MP0002396_abnormal_hematopoietic_system0.83085177
84MP0000762_abnormal_tongue_morphology0.82369073
85MP0006072_abnormal_retinal_apoptosis0.82074559
86MP0000778_abnormal_nervous_system0.80613201
87MP0003123_paternal_imprinting0.79122043
88MP0003698_abnormal_male_reproductive0.78573462
89MP0003699_abnormal_female_reproductive0.78142936
90MP0005084_abnormal_gallbladder_morpholo0.77531610
91MP0000516_abnormal_urinary_system0.74994309
92MP0005367_renal/urinary_system_phenotyp0.74994309
93MP0005187_abnormal_penis_morphology0.73984648
94MP0002081_perinatal_lethality0.71630728
95MP0005391_vision/eye_phenotype0.71479871
96MP0003385_abnormal_body_wall0.70065564
97MP0002161_abnormal_fertility/fecundity0.69360666
98MP0001340_abnormal_eyelid_morphology0.68317252
99MP0003115_abnormal_respiratory_system0.67480247
100MP0009053_abnormal_anal_canal0.64484383

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.39379192
2Abnormality of the labia minora (HP:0012880)4.20651824
3Septo-optic dysplasia (HP:0100842)3.91381049
4Chromsome breakage (HP:0040012)3.84429499
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75885488
6Volvulus (HP:0002580)3.72193612
7Nephroblastoma (Wilms tumor) (HP:0002667)3.36253224
8Abnormal lung lobation (HP:0002101)3.29858763
9Abnormality of chromosome stability (HP:0003220)3.26111481
10Embryonal renal neoplasm (HP:0011794)3.24255227
11Medulloblastoma (HP:0002885)3.05084838
12Meckel diverticulum (HP:0002245)2.97920621
13Birth length less than 3rd percentile (HP:0003561)2.95731316
14Abnormality of the septum pellucidum (HP:0007375)2.85175555
15Abnormality of the ileum (HP:0001549)2.79634238
16Rhabdomyosarcoma (HP:0002859)2.76746571
17Absent septum pellucidum (HP:0001331)2.67148781
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.64494986
19Cortical dysplasia (HP:0002539)2.54079636
20Ependymoma (HP:0002888)2.48627543
21Small intestinal stenosis (HP:0012848)2.41410304
22Duodenal stenosis (HP:0100867)2.41410304
23Supernumerary spleens (HP:0009799)2.37250688
24Abnormality of the duodenum (HP:0002246)2.35573230
25Aplasia/Hypoplasia of the sternum (HP:0006714)2.35518560
26Shoulder girdle muscle weakness (HP:0003547)2.34523642
27Abnormality of the preputium (HP:0100587)2.34083067
28Abnormality of methionine metabolism (HP:0010901)2.31395366
29Stenosis of the external auditory canal (HP:0000402)2.30903949
30Hepatoblastoma (HP:0002884)2.28337060
31Increased nuchal translucency (HP:0010880)2.25935918
32Absent radius (HP:0003974)2.24804589
33Abnormal hair whorl (HP:0010721)2.22995237
34Ectopic kidney (HP:0000086)2.22546591
35Carpal bone hypoplasia (HP:0001498)2.21871870
36Multiple enchondromatosis (HP:0005701)2.21086042
37Pancreatic islet-cell hyperplasia (HP:0004510)2.20687520
38Papillary thyroid carcinoma (HP:0002895)2.14240875
39Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11957741
40Neoplasm of the colon (HP:0100273)2.10444056
41Bilateral microphthalmos (HP:0007633)2.09704873
42Aplasia involving forearm bones (HP:0009822)2.08003830
43Absent forearm bone (HP:0003953)2.08003830
44Oligodactyly (hands) (HP:0001180)2.04388505
45Maternal diabetes (HP:0009800)2.04160501
46Intestinal atresia (HP:0011100)2.03076650
47Glioma (HP:0009733)2.02338231
48Agnosia (HP:0010524)2.02005851
49Biliary tract neoplasm (HP:0100574)2.01055729
50Optic nerve hypoplasia (HP:0000609)2.00959364
51Bifid tongue (HP:0010297)2.00636796
52Breast aplasia (HP:0100783)2.00109883
53Gonadotropin excess (HP:0000837)1.97599699
54Methylmalonic acidemia (HP:0002912)1.94266387
55Myelodysplasia (HP:0002863)1.94193790
56Homocystinuria (HP:0002156)1.94151776
57Abnormality of homocysteine metabolism (HP:0010919)1.94151776
58Sloping forehead (HP:0000340)1.94044893
59Reticulocytopenia (HP:0001896)1.90043018
60Triphalangeal thumb (HP:0001199)1.89588217
61Short middle phalanx of the 5th finger (HP:0004220)1.87766194
62Aqueductal stenosis (HP:0002410)1.87493951
63Abdominal situs inversus (HP:0003363)1.86699458
64Abnormality of abdominal situs (HP:0011620)1.86699458
65Aplastic anemia (HP:0001915)1.86347674
66Spastic diplegia (HP:0001264)1.85710297
67Horseshoe kidney (HP:0000085)1.85417496
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85414319
69Median cleft lip (HP:0000161)1.84677160
70Hypoplastic female external genitalia (HP:0012815)1.84531061
71Hyperglycinemia (HP:0002154)1.83541274
72Gastrointestinal carcinoma (HP:0002672)1.83028351
73Malignant gastrointestinal tract tumors (HP:0006749)1.83028351
74Aplasia/Hypoplasia of the breasts (HP:0010311)1.82539136
75Astrocytoma (HP:0009592)1.82092802
76Abnormality of the astrocytes (HP:0100707)1.82092802
77Esophageal atresia (HP:0002032)1.77102479
78Neoplasm of the oral cavity (HP:0100649)1.76590323
79Neoplasm of the adrenal cortex (HP:0100641)1.76561121
80Hypoglycemic seizures (HP:0002173)1.76150798
81Labial hypoplasia (HP:0000066)1.76025617
82Small hand (HP:0200055)1.74601182
83Proximal placement of thumb (HP:0009623)1.74174478
84Choanal atresia (HP:0000453)1.73149369
85Neoplasm of the small intestine (HP:0100833)1.72816885
86Abnormality of serum amino acid levels (HP:0003112)1.72354634
87Sensory axonal neuropathy (HP:0003390)1.71179176
88Gastrointestinal atresia (HP:0002589)1.71063504
89Facial cleft (HP:0002006)1.70121060
90Cellular immunodeficiency (HP:0005374)1.68876299
91Neoplasm of striated muscle (HP:0009728)1.68141004
92Embryonal neoplasm (HP:0002898)1.67051322
93Hypoplastic labia majora (HP:0000059)1.65661594
94Uterine neoplasm (HP:0010784)1.65403356
95Pelvic girdle muscle weakness (HP:0003749)1.64444779
96Megaloblastic anemia (HP:0001889)1.63415685
97Hypoplastic pelvis (HP:0008839)1.63341509
98Deviation of the thumb (HP:0009603)1.63172686
99Thyroid carcinoma (HP:0002890)1.62768403
100Abnormal number of incisors (HP:0011064)1.62033263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.60756535
2PNCK3.34784423
3BUB13.14797572
4TTK3.01951253
5TSSK62.99923720
6SRPK12.92640529
7MKNK22.91653561
8WEE12.67659439
9BRSK22.52426083
10TNIK2.34117396
11MKNK12.32909930
12PLK42.32348926
13TAF12.28630940
14TRIM282.22147982
15PLK32.21152773
16PBK2.11490434
17NUAK12.00757939
18EIF2AK31.98004662
19WNK31.95912079
20NEK11.84675241
21STK38L1.84041761
22BRD41.78691927
23MST41.75426007
24CDK191.65533530
25PLK11.62972276
26DYRK31.62901392
27ZAK1.62254999
28MAP3K101.55286622
29ERBB41.50553635
30VRK21.43799137
31STK31.42637550
32VRK11.38746293
33CASK1.37376353
34BCR1.33316247
35LATS11.29873312
36STK161.26646004
37NEK21.20315612
38CAMK1G1.19149255
39CHEK21.14516922
40ACVR1B1.10343548
41DYRK21.04002783
42CSNK1G11.02880670
43ATR1.01233490
44STK240.98151386
45CHEK10.89182049
46FGFR10.88808087
47ATM0.87484492
48NLK0.86941887
49BMPR1B0.85460492
50EIF2AK20.85011059
51ALK0.83623626
52AURKB0.83284637
53MAP3K40.78547670
54PASK0.77363303
55CDK30.76106018
56NME10.75773821
57BRSK10.75597156
58CSNK1G20.72759973
59YES10.72603597
60CDK70.71876934
61MAP3K90.70717569
62CDK120.66166154
63STK40.63690159
64CSNK1E0.62601330
65OXSR10.61847583
66EIF2AK10.61688889
67PLK20.59389371
68PDK20.58825686
69CDK20.57192995
70LATS20.56508626
71BRAF0.56460099
72DMPK0.56127639
73KSR10.55862094
74RPS6KA40.54186904
75CDK10.52958554
76FLT30.52481938
77MET0.51893948
78RAF10.50786445
79CSNK1G30.49767892
80MELK0.49133749
81AURKA0.49090557
82PIM10.47807907
83ERBB30.46032029
84CSNK1A1L0.45972504
85MAP2K70.45015399
86CDK60.43591160
87CLK10.43259822
88AKT30.42046310
89CSNK2A20.40156826
90CSNK2A10.38639162
91DYRK1A0.38404268
92PRKDC0.38354458
93MAP3K80.33014050
94MINK10.32377864
95EGFR0.31949120
96NEK60.27037341
97CDK90.26118419
98FGR0.24285848
99MAP4K20.24163771
100CAMK1D0.21892278

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.05486438
2DNA replication_Homo sapiens_hsa030303.62314372
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58710664
4Non-homologous end-joining_Homo sapiens_hsa034503.18261704
5RNA transport_Homo sapiens_hsa030133.03477888
6Cell cycle_Homo sapiens_hsa041103.02811385
7Basal transcription factors_Homo sapiens_hsa030222.89886455
8Spliceosome_Homo sapiens_hsa030402.88587673
9Proteasome_Homo sapiens_hsa030502.77931737
10Homologous recombination_Homo sapiens_hsa034402.77740376
11RNA polymerase_Homo sapiens_hsa030202.61861824
12RNA degradation_Homo sapiens_hsa030182.53625753
13Fanconi anemia pathway_Homo sapiens_hsa034602.40025626
14Base excision repair_Homo sapiens_hsa034102.32277308
15Protein export_Homo sapiens_hsa030602.26882081
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26667162
17Selenocompound metabolism_Homo sapiens_hsa004502.25064151
18mRNA surveillance pathway_Homo sapiens_hsa030152.17657205
19Nucleotide excision repair_Homo sapiens_hsa034202.14001577
20Ribosome_Homo sapiens_hsa030101.77053204
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.73641270
22One carbon pool by folate_Homo sapiens_hsa006701.69994107
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66055458
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63971514
25p53 signaling pathway_Homo sapiens_hsa041151.56438185
26Steroid biosynthesis_Homo sapiens_hsa001001.55746149
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53956165
28Oocyte meiosis_Homo sapiens_hsa041141.45635898
29Pyrimidine metabolism_Homo sapiens_hsa002401.30724801
30TGF-beta signaling pathway_Homo sapiens_hsa043501.23356591
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19813208
32Parkinsons disease_Homo sapiens_hsa050121.09053177
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05930029
34Huntingtons disease_Homo sapiens_hsa050161.03676480
35Purine metabolism_Homo sapiens_hsa002300.99605614
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98962785
37Pyruvate metabolism_Homo sapiens_hsa006200.95828126
38Hippo signaling pathway_Homo sapiens_hsa043900.94051811
39Wnt signaling pathway_Homo sapiens_hsa043100.92094758
40Adherens junction_Homo sapiens_hsa045200.89873508
41Oxidative phosphorylation_Homo sapiens_hsa001900.89055984
42Vitamin B6 metabolism_Homo sapiens_hsa007500.81051240
43Propanoate metabolism_Homo sapiens_hsa006400.81031262
44Basal cell carcinoma_Homo sapiens_hsa052170.78097983
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77902160
46MicroRNAs in cancer_Homo sapiens_hsa052060.76608176
47Thyroid cancer_Homo sapiens_hsa052160.75898040
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72317414
49Hedgehog signaling pathway_Homo sapiens_hsa043400.68412728
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67890986
51Colorectal cancer_Homo sapiens_hsa052100.66733305
52Vitamin digestion and absorption_Homo sapiens_hsa049770.63679028
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58626993
54Prostate cancer_Homo sapiens_hsa052150.56690663
55Biosynthesis of amino acids_Homo sapiens_hsa012300.53069401
56Epstein-Barr virus infection_Homo sapiens_hsa051690.51394040
57Lysine degradation_Homo sapiens_hsa003100.47160527
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43299542
59Viral carcinogenesis_Homo sapiens_hsa052030.42128056
60Alzheimers disease_Homo sapiens_hsa050100.41214181
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40629726
62Folate biosynthesis_Homo sapiens_hsa007900.40492146
63Tight junction_Homo sapiens_hsa045300.40154493
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38834226
65Melanoma_Homo sapiens_hsa052180.37017659
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35766920
67Regulation of autophagy_Homo sapiens_hsa041400.34730396
68Small cell lung cancer_Homo sapiens_hsa052220.33074069
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32606046
70Fatty acid elongation_Homo sapiens_hsa000620.32506187
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31976861
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31502730
73Metabolic pathways_Homo sapiens_hsa011000.31013663
74Alcoholism_Homo sapiens_hsa050340.30168327
75Caffeine metabolism_Homo sapiens_hsa002320.29682786
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28720917
77Pathways in cancer_Homo sapiens_hsa052000.28501092
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28100846
79Nicotine addiction_Homo sapiens_hsa050330.27653387
80Phototransduction_Homo sapiens_hsa047440.27135685
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26656206
82N-Glycan biosynthesis_Homo sapiens_hsa005100.26345239
83Circadian rhythm_Homo sapiens_hsa047100.25934205
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22984300
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22008132
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21921698
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21808550
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20144705
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19847151
90Glutathione metabolism_Homo sapiens_hsa004800.19745796
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19578255
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19213039
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18947801
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18527062
95Shigellosis_Homo sapiens_hsa051310.17426171
96Retinol metabolism_Homo sapiens_hsa008300.15882025
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.15206883
98Endometrial cancer_Homo sapiens_hsa052130.15153664
99Taste transduction_Homo sapiens_hsa047420.15020277
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14555415

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