ZNF282

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular protein complex localization (GO:0034629)5.34574718
2protein complex localization (GO:0031503)4.61041782
3regulation of mammary gland epithelial cell proliferation (GO:0033599)4.60322777
4DNA unwinding involved in DNA replication (GO:0006268)4.03162302
5apoptotic process involved in morphogenesis (GO:0060561)3.97590554
6adherens junction assembly (GO:0034333)3.79382741
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.79377731
8regulation of NFAT protein import into nucleus (GO:0051532)3.79359864
9regulation of chromatin binding (GO:0035561)3.76098324
10mitotic chromosome condensation (GO:0007076)3.75587049
11peptidyl-arginine omega-N-methylation (GO:0035247)3.74650737
12protein retention in ER lumen (GO:0006621)3.71948118
13heterochromatin organization (GO:0070828)3.71297547
14regulation of translational fidelity (GO:0006450)3.62984480
15proline biosynthetic process (GO:0006561)3.60650392
16COPI coating of Golgi vesicle (GO:0048205)3.55035536
17Golgi transport vesicle coating (GO:0048200)3.55035536
18negative regulation of erythrocyte differentiation (GO:0045647)3.54794450
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49695578
20focal adhesion assembly (GO:0048041)3.48397075
21cell-substrate adherens junction assembly (GO:0007045)3.48397075
22activation of Rac GTPase activity (GO:0032863)3.43402288
23nuclear pore complex assembly (GO:0051292)3.41679701
24spliceosomal tri-snRNP complex assembly (GO:0000244)3.41423065
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.37087440
26protein localization to endosome (GO:0036010)3.35111656
27regulation of glucose import in response to insulin stimulus (GO:2001273)3.32827002
28regulation of early endosome to late endosome transport (GO:2000641)3.19815700
29regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.17906099
30regulation of RNA export from nucleus (GO:0046831)3.14645101
31negative regulation of cell size (GO:0045792)3.12642836
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11611235
33lymph vessel development (GO:0001945)3.07865494
34intracellular estrogen receptor signaling pathway (GO:0030520)3.06952625
35regulation of apoptotic process involved in morphogenesis (GO:1902337)3.05383010
36maternal placenta development (GO:0001893)3.05128385
37cell-substrate junction assembly (GO:0007044)3.03344625
38peptidyl-arginine methylation (GO:0018216)3.02852454
39peptidyl-arginine N-methylation (GO:0035246)3.02852454
403-UTR-mediated mRNA stabilization (GO:0070935)3.01755469
41histone arginine methylation (GO:0034969)3.00419383
42regulation of nucleobase-containing compound transport (GO:0032239)2.96838702
43DNA replication initiation (GO:0006270)2.96150678
44negative regulation of viral release from host cell (GO:1902187)2.90146337
45nucleosome disassembly (GO:0006337)2.89569982
46protein-DNA complex disassembly (GO:0032986)2.89569982
47peptidyl-lysine dimethylation (GO:0018027)2.89517717
48atrioventricular valve morphogenesis (GO:0003181)2.89053341
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.88621644
50pentose-phosphate shunt (GO:0006098)2.86028821
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85879740
52basement membrane organization (GO:0071711)2.83248408
53desmosome organization (GO:0002934)2.83091612
54mRNA stabilization (GO:0048255)2.82792136
55RNA stabilization (GO:0043489)2.82792136
56embryonic process involved in female pregnancy (GO:0060136)2.79297942
57positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.78197742
58chromatin assembly (GO:0031497)2.76898759
59DNA strand elongation involved in DNA replication (GO:0006271)2.76281037
60nuclear pore organization (GO:0006999)2.73615053
61epithelial cell-cell adhesion (GO:0090136)2.73282819
62DNA strand elongation (GO:0022616)2.72623455
63ribosomal small subunit biogenesis (GO:0042274)2.72445345
64regulation of translational termination (GO:0006449)2.70963069
65snRNA metabolic process (GO:0016073)2.66434424
66mitotic G1 DNA damage checkpoint (GO:0031571)2.64646180
67semaphorin-plexin signaling pathway (GO:0071526)2.64005057
68mitotic sister chromatid segregation (GO:0000070)2.63712696
69hemidesmosome assembly (GO:0031581)2.61794341
70epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61487396
71vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.61165243
72trophectodermal cell differentiation (GO:0001829)2.59955350
73apoptotic process involved in development (GO:1902742)2.59262711
74activation of MAPKKK activity (GO:0000185)2.56765659
75glucose catabolic process (GO:0006007)2.56733654
76nuclear envelope reassembly (GO:0031468)2.56624605
77mitotic nuclear envelope reassembly (GO:0007084)2.56624605
78pore complex assembly (GO:0046931)2.55053818
79branching involved in mammary gland duct morphogenesis (GO:0060444)2.51874965
80trophoblast giant cell differentiation (GO:0060707)2.49073324
81convergent extension (GO:0060026)2.48684047
82cellular response to epidermal growth factor stimulus (GO:0071364)2.47201971
83embryonic eye morphogenesis (GO:0048048)2.47144295
84diaphragm development (GO:0060539)2.46469539
85dosage compensation (GO:0007549)2.46440799
86mammary gland epithelial cell differentiation (GO:0060644)2.46396128
87cell-cell junction maintenance (GO:0045217)2.45300016
88positive regulation of histone deacetylation (GO:0031065)2.44954890
89negative regulation of mRNA processing (GO:0050686)2.44031092
90intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.43365669
91negative regulation of mRNA metabolic process (GO:1903312)2.43311949
92folic acid metabolic process (GO:0046655)2.43123018
93modulation by symbiont of host cellular process (GO:0044068)2.42806866
94L-serine metabolic process (GO:0006563)2.42355283
95protein localization to microtubule (GO:0035372)2.42282683
96activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41786134
97negative regulation of fatty acid transport (GO:2000192)2.41402197
98establishment of apical/basal cell polarity (GO:0035089)2.41311112
99G1 DNA damage checkpoint (GO:0044783)2.39845932
100mitotic G1/S transition checkpoint (GO:0044819)2.39844080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.21571802
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.26867725
3* MYC_22102868_ChIP-Seq_BL_Human2.97316516
4VDR_21846776_ChIP-Seq_THP-1_Human2.72158313
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45391180
6LXR_22292898_ChIP-Seq_THP-1_Human2.40111248
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.39410867
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.38027823
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35294077
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28588075
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.24270876
12RACK7_27058665_Chip-Seq_MCF-7_Human2.15204421
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08120651
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07489706
15ZNF263_19887448_ChIP-Seq_K562_Human2.04616840
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.94080882
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91867615
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.90934217
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89956229
20KDM2B_26808549_Chip-Seq_DND41_Human1.88716410
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86405503
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85804100
23TCF7_22412390_ChIP-Seq_EML_Mouse1.85695216
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84164152
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76933756
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76267721
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74516476
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72027472
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70632200
30KDM2B_26808549_Chip-Seq_K562_Human1.67659389
31CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64674796
32XRN2_22483619_ChIP-Seq_HELA_Human1.57419701
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53991934
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53244318
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52324363
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48804256
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47743687
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.45829483
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44836394
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44379233
41P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44141010
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43910228
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43299969
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41530208
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40775582
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38151818
47P68_20966046_ChIP-Seq_HELA_Human1.36989699
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35511953
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.34484339
50ATF3_27146783_Chip-Seq_COLON_Human1.31309388
51CREB1_26743006_Chip-Seq_LNCaP_Human1.29985105
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29828740
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.29811538
54* NCOR1_26117541_ChIP-Seq_K562_Human1.29162473
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28619435
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27572108
57MAF_26560356_Chip-Seq_TH1_Human1.27551397
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26088314
59VDR_24763502_ChIP-Seq_THP-1_Human1.24536948
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23843171
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23461849
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23325699
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23196636
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.22994285
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22013396
66CLOCK_20551151_ChIP-Seq_293T_Human1.20846278
67AR_21909140_ChIP-Seq_LNCAP_Human1.20615330
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18910323
69MAF_26560356_Chip-Seq_TH2_Human1.16509584
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14921904
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12762220
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12063446
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11494462
74SMC4_20622854_ChIP-Seq_HELA_Human1.11455064
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11361258
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.11286433
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10732869
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09514370
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09454420
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.08988899
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08387298
82* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07398655
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06119846
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06004808
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05816390
86UTX_26944678_Chip-Seq_JUKART_Human1.04693734
87CIITA_25753668_ChIP-Seq_RAJI_Human1.04499594
88TP53_22127205_ChIP-Seq_IMR90_Human1.04401681
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03581207
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02230200
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.01082603
92MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00719399
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99870457
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99841928
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98872081
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98157423
97CHD1_26751641_Chip-Seq_LNCaP_Human0.97148805
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97067197
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95874901
100KDM5A_27292631_Chip-Seq_BREAST_Human0.95230582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.21978632
2MP0005076_abnormal_cell_differentiation2.84657915
3MP0002877_abnormal_melanocyte_morpholog2.56638591
4MP0004185_abnormal_adipocyte_glucose2.55415836
5MP0005451_abnormal_body_composition2.54930292
6MP0003111_abnormal_nucleus_morphology2.29274642
7MP0002249_abnormal_larynx_morphology2.26878669
8MP0000678_abnormal_parathyroid_gland2.20671091
9MP0005623_abnormal_meninges_morphology2.20157487
10MP0008438_abnormal_cutaneous_collagen2.15731552
11MP0000537_abnormal_urethra_morphology2.12384895
12MP0001849_ear_inflammation2.10550334
13MP0003693_abnormal_embryo_hatching2.09557677
14MP0004858_abnormal_nervous_system2.00639419
15MP0005409_darkened_coat_color1.98068290
16MP0010234_abnormal_vibrissa_follicle1.93090062
17MP0003453_abnormal_keratinocyte_physiol1.91496427
18MP0010352_gastrointestinal_tract_polyps1.89376338
19MP0010030_abnormal_orbit_morphology1.89058867
20MP0003566_abnormal_cell_adhesion1.87311459
21MP0002796_impaired_skin_barrier1.85462987
22MP0005058_abnormal_lysosome_morphology1.83253888
23MP0001730_embryonic_growth_arrest1.75469680
24MP0009053_abnormal_anal_canal1.67527047
25MP0001346_abnormal_lacrimal_gland1.60738451
26MP0004272_abnormal_basement_membrane1.60362024
27MP0004957_abnormal_blastocyst_morpholog1.56241511
28MP0005501_abnormal_skin_physiology1.55689892
29MP0003077_abnormal_cell_cycle1.52650550
30MP0009278_abnormal_bone_marrow1.52351548
31MP0004233_abnormal_muscle_weight1.50297188
32MP0000350_abnormal_cell_proliferation1.46929128
33MP0005666_abnormal_adipose_tissue1.43889630
34MP0000733_abnormal_muscle_development1.42783793
35MP0000003_abnormal_adipose_tissue1.40226500
36MP0009672_abnormal_birth_weight1.39168144
37MP0003942_abnormal_urinary_system1.34349389
38MP0002089_abnormal_postnatal_growth/wei1.33957360
39MP0005375_adipose_tissue_phenotype1.33038323
40MP0008260_abnormal_autophagy1.28969217
41MP0002060_abnormal_skin_morphology1.28602164
42MP0003091_abnormal_cell_migration1.28151533
43MP0002009_preneoplasia1.26459050
44MP0010094_abnormal_chromosome_stability1.26085180
45MP0008932_abnormal_embryonic_tissue1.22918633
46MP0002396_abnormal_hematopoietic_system1.22041733
47MP0009840_abnormal_foam_cell1.21987920
48MP0000566_synostosis1.18620158
49MP0005380_embryogenesis_phenotype1.17028611
50MP0001672_abnormal_embryogenesis/_devel1.17028611
51MP0002080_prenatal_lethality1.16811259
52MP0003984_embryonic_growth_retardation1.15882728
53MP0002697_abnormal_eye_size1.13090797
54MP0002085_abnormal_embryonic_tissue1.12575663
55MP0004808_abnormal_hematopoietic_stem1.12289162
56MP0002086_abnormal_extraembryonic_tissu1.11741730
57MP0000579_abnormal_nail_morphology1.10789965
58MP0002088_abnormal_embryonic_growth/wei1.08574741
59MP0009333_abnormal_splenocyte_physiolog1.08452095
60MP0001216_abnormal_epidermal_layer1.06996626
61MP0005257_abnormal_intraocular_pressure1.06831766
62MP0001348_abnormal_lacrimal_gland1.04186476
63MP0000490_abnormal_crypts_of1.03988672
64MP0003303_peritoneal_inflammation1.01786241
65MP0003115_abnormal_respiratory_system1.00065741
66MP0002098_abnormal_vibrissa_morphology0.99788893
67MP0004947_skin_inflammation0.99495005
68MP0009931_abnormal_skin_appearance0.97993638
69MP0001697_abnormal_embryo_size0.96355159
70MP0010307_abnormal_tumor_latency0.95960609
71MP0003941_abnormal_skin_development0.95408880
72MP0000313_abnormal_cell_death0.95113168
73MP0005621_abnormal_cell_physiology0.93297340
74MP0003315_abnormal_perineum_morphology0.92726993
75MP0004264_abnormal_extraembryonic_tissu0.92133408
76MP0002092_abnormal_eye_morphology0.91615229
77MP0000428_abnormal_craniofacial_morphol0.91562389
78MP0000762_abnormal_tongue_morphology0.89962771
79MP0001915_intracranial_hemorrhage0.89728745
80MP0010630_abnormal_cardiac_muscle0.89669599
81MP0000858_altered_metastatic_potential0.89587924
82MP0000534_abnormal_ureter_morphology0.89303616
83MP0002084_abnormal_developmental_patter0.88104998
84MP0000467_abnormal_esophagus_morphology0.87524357
85MP0000759_abnormal_skeletal_muscle0.87191435
86MP0003123_paternal_imprinting0.83630878
87MP0005023_abnormal_wound_healing0.82233594
88MP0008007_abnormal_cellular_replicative0.81592664
89MP0000767_abnormal_smooth_muscle0.80599879
90MP0004197_abnormal_fetal_growth/weight/0.79440422
91MP0003279_aneurysm0.79118727
92MP0002925_abnormal_cardiovascular_devel0.77840999
93MP0005508_abnormal_skeleton_morphology0.77637336
94MP0000377_abnormal_hair_follicle0.77538352
95MP0009384_cardiac_valve_regurgitation0.77091303
96MP0000681_abnormal_thyroid_gland0.75684473
97MP0003385_abnormal_body_wall0.73941965
98MP0002114_abnormal_axial_skeleton0.73380419
99MP0003172_abnormal_lysosome_physiology0.73312531
100MP0001340_abnormal_eyelid_morphology0.69775150

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.83233793
2Ulnar bowing (HP:0003031)3.02803808
3Abnormality of the distal phalanx of the thumb (HP:0009617)2.80236627
4Disproportionate tall stature (HP:0001519)2.74101755
5Protrusio acetabuli (HP:0003179)2.73476869
6Broad distal phalanx of finger (HP:0009836)2.71700274
7Abnormality of the phalanges of the hallux (HP:0010057)2.64963680
8Achilles tendon contracture (HP:0001771)2.58074188
9Distal lower limb amyotrophy (HP:0008944)2.54698091
10Septate vagina (HP:0001153)2.47068189
11Increased connective tissue (HP:0009025)2.45844898
12Broad face (HP:0000283)2.44278082
13Long palpebral fissure (HP:0000637)2.44142776
14Premature rupture of membranes (HP:0001788)2.43422414
15Insomnia (HP:0100785)2.40458064
16Progressive muscle weakness (HP:0003323)2.39188459
17Biconcave vertebral bodies (HP:0004586)2.38645143
18Asymmetry of the thorax (HP:0001555)2.37171763
19Cerebral aneurysm (HP:0004944)2.36446193
20Obstructive sleep apnea (HP:0002870)2.34693008
21Shallow orbits (HP:0000586)2.34043571
22Abnormality of the distal phalanges of the toes (HP:0010182)2.33435459
23Trismus (HP:0000211)2.32530165
24Vertebral compression fractures (HP:0002953)2.30877640
25Truncus arteriosus (HP:0001660)2.23068718
26Selective tooth agenesis (HP:0001592)2.22072256
27Abnormality of the Achilles tendon (HP:0005109)2.21617686
28Upper limb amyotrophy (HP:0009129)2.20561647
29Distal upper limb amyotrophy (HP:0007149)2.20561647
30Nonimmune hydrops fetalis (HP:0001790)2.13303630
31Fragile skin (HP:0001030)2.13150198
32Abnormality of the fingertips (HP:0001211)2.12502761
33High anterior hairline (HP:0009890)2.06720746
34Patellar dislocation (HP:0002999)2.04755119
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.04710865
36Thin bony cortex (HP:0002753)2.02477629
37Abnormality of the thoracic spine (HP:0100711)2.02427953
38Abnormality of the umbilical cord (HP:0010881)2.00541841
39Abnormality of the fetal cardiovascular system (HP:0010948)2.00430246
40Abnormal umbilical cord blood vessels (HP:0011403)2.00430246
41Single umbilical artery (HP:0001195)2.00430246
42Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99206075
43Ankyloglossia (HP:0010296)1.98580246
44Bowel incontinence (HP:0002607)1.97825465
45Hypercalcemia (HP:0003072)1.96922544
46Advanced eruption of teeth (HP:0006288)1.96715581
47Syringomyelia (HP:0003396)1.96100152
48Spinal cord lesions (HP:0100561)1.96100152
49Overriding aorta (HP:0002623)1.95477088
50Breast hypoplasia (HP:0003187)1.94290211
51Abnormal large intestine physiology (HP:0012700)1.91419853
52Pointed chin (HP:0000307)1.89593827
53Abnormality of the aortic arch (HP:0012303)1.89140916
54Elfin facies (HP:0004428)1.88513587
55Genu recurvatum (HP:0002816)1.87753384
56Natal tooth (HP:0000695)1.87562191
57Dysmetric saccades (HP:0000641)1.85583573
58Stridor (HP:0010307)1.85549239
59Increased variability in muscle fiber diameter (HP:0003557)1.85274080
60Flat acetabular roof (HP:0003180)1.85163440
61Germ cell neoplasia (HP:0100728)1.84892153
62Mitral regurgitation (HP:0001653)1.83846756
63Abnormality of the calcaneus (HP:0008364)1.83823490
64Hyperparathyroidism (HP:0000843)1.82473013
65Premature skin wrinkling (HP:0100678)1.81315761
66Short nail (HP:0001799)1.80561702
67Spinal rigidity (HP:0003306)1.80531036
68Transposition of the great arteries (HP:0001669)1.78700203
69Abnormal connection of the cardiac segments (HP:0011545)1.78700203
70Abnormal ventriculo-arterial connection (HP:0011563)1.78700203
71Hypertensive crisis (HP:0100735)1.78398197
72Arnold-Chiari malformation (HP:0002308)1.77433649
73Renal duplication (HP:0000075)1.77028536
74Abnormality of oral frenula (HP:0000190)1.71635083
75Abnormality of skeletal muscle fiber size (HP:0012084)1.71432652
76Deep palmar crease (HP:0006191)1.69870900
77Blue sclerae (HP:0000592)1.69582545
78Lower limb amyotrophy (HP:0007210)1.69031035
79Bladder diverticulum (HP:0000015)1.68592596
80Deviation of the thumb (HP:0009603)1.66927791
81Distal lower limb muscle weakness (HP:0009053)1.66229362
82Myopathic facies (HP:0002058)1.65877948
83Generalized amyotrophy (HP:0003700)1.65591102
84Sparse lateral eyebrow (HP:0005338)1.65347290
85J-shaped sella turcica (HP:0002680)1.64985757
86Abnormality of the columella (HP:0009929)1.63978431
87Pseudobulbar signs (HP:0002200)1.63101285
88Hand muscle atrophy (HP:0009130)1.63082016
89Abnormal gallbladder physiology (HP:0012438)1.62420522
90Cholecystitis (HP:0001082)1.62420522
91Metaphyseal cupping (HP:0003021)1.61338650
92Long eyelashes (HP:0000527)1.60546308
93Cervical subluxation (HP:0003308)1.60341855
94Mitral valve prolapse (HP:0001634)1.60156631
95Atrophic scars (HP:0001075)1.59688858
96Increased nuchal translucency (HP:0010880)1.59686272
97Abnormality of the salivary glands (HP:0010286)1.58954287
98Elbow flexion contracture (HP:0002987)1.58566576
99Short clavicles (HP:0000894)1.58261510
100Multiple enchondromatosis (HP:0005701)1.57370835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.12477417
2SMG14.74317405
3EEF2K3.98513364
4CDK123.19179792
5ICK3.15815741
6PRPF4B3.03730603
7SIK13.00989853
8IRAK32.96233010
9MAP3K102.59126227
10NME22.24073676
11ERN11.97652312
12RIPK11.96924021
13EPHA21.78933773
14PKN21.62590234
15VRK21.59433721
16TTN1.50373962
17PDGFRA1.36820792
18TAOK21.35147373
19MTOR1.32984303
20MAP2K31.23778538
21FGFR41.16140825
22PAK41.15691187
23CDK71.12390993
24MAP3K81.09812273
25CAMK1D1.09663903
26ARAF1.08856613
27BRAF1.02813025
28KSR21.00588610
29MARK20.99759897
30RPS6KB20.98289797
31CDC70.97512001
32PTK60.97286396
33MST1R0.95990140
34CHEK20.93839667
35PRKD30.92951821
36LATS20.90449580
37CDK40.90241859
38RPS6KC10.89953819
39RPS6KL10.89953819
40BUB10.89702776
41TYRO30.86639006
42MAP3K110.86192613
43RPS6KA20.86065811
44PIM20.85685974
45IRAK20.84510078
46BRD40.83045703
47IRAK40.79930451
48PTK20.79375435
49HIPK20.79062756
50TAOK10.78148090
51MAP3K130.77375969
52CAMK1G0.75629134
53PRKD20.74983208
54CLK10.73376958
55MAP3K10.72750954
56KDR0.70703557
57MAPK110.68231081
58RPS6KA60.65298799
59AURKA0.64226385
60MAP3K30.63857717
61TAF10.63421720
62BMX0.62140952
63CDC42BPA0.61710094
64MAP2K20.60225082
65PDPK10.54495604
66CHEK10.53330859
67TTK0.52065631
68NTRK10.51239361
69TESK20.50146978
70DDR20.49439675
71CDK60.49413993
72BLK0.49294792
73LMTK20.49227251
74RPS6KA10.47788111
75NEK20.44762465
76AKT20.44581677
77ILK0.43480408
78STK40.42993628
79LRRK20.42014863
80CDK90.41217884
81PDGFRB0.40287353
82MAP3K90.39261287
83CDK80.38437200
84SIK20.38387447
85ALK0.38133428
86RAF10.37608692
87EPHB20.37285624
88CDK20.36587630
89TBK10.36367552
90ATR0.35912462
91MAP3K60.35261446
92DMPK0.35106235
93MET0.34253715
94TESK10.33507538
95EPHB10.31321304
96PAK20.30507640
97CDK10.29801066
98EIF2AK20.29495587
99DAPK30.29108588
100SGK30.27301117

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.48850809
2DNA replication_Homo sapiens_hsa030302.40252468
3Bladder cancer_Homo sapiens_hsa052192.29766810
4Notch signaling pathway_Homo sapiens_hsa043302.18741079
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.15592238
6Sulfur relay system_Homo sapiens_hsa041222.11462638
7Acute myeloid leukemia_Homo sapiens_hsa052211.98875818
8Non-small cell lung cancer_Homo sapiens_hsa052231.93870506
9Central carbon metabolism in cancer_Homo sapiens_hsa052301.87480079
10Other glycan degradation_Homo sapiens_hsa005111.77286278
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76805002
12Thyroid cancer_Homo sapiens_hsa052161.74694775
13VEGF signaling pathway_Homo sapiens_hsa043701.61840752
14Pancreatic cancer_Homo sapiens_hsa052121.58821191
15Endometrial cancer_Homo sapiens_hsa052131.58158879
16Biosynthesis of amino acids_Homo sapiens_hsa012301.52358114
17Pentose phosphate pathway_Homo sapiens_hsa000301.48603788
18Base excision repair_Homo sapiens_hsa034101.36019841
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36003770
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35390508
21Renal cell carcinoma_Homo sapiens_hsa052111.35307993
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.34680106
23Glioma_Homo sapiens_hsa052141.34476925
24MicroRNAs in cancer_Homo sapiens_hsa052061.33997950
25ErbB signaling pathway_Homo sapiens_hsa040121.33018905
26Cell cycle_Homo sapiens_hsa041101.29825880
27Prion diseases_Homo sapiens_hsa050201.28692291
28Insulin signaling pathway_Homo sapiens_hsa049101.26903371
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.26299084
30Small cell lung cancer_Homo sapiens_hsa052221.25686260
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25026021
32Fructose and mannose metabolism_Homo sapiens_hsa000511.23043070
33Lysine degradation_Homo sapiens_hsa003101.22672572
34B cell receptor signaling pathway_Homo sapiens_hsa046621.21329862
35Viral carcinogenesis_Homo sapiens_hsa052031.20816151
36mTOR signaling pathway_Homo sapiens_hsa041501.19923684
37Prostate cancer_Homo sapiens_hsa052151.16654162
38Colorectal cancer_Homo sapiens_hsa052101.12133731
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10311355
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09439302
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04399540
42Spliceosome_Homo sapiens_hsa030401.04237005
43Apoptosis_Homo sapiens_hsa042101.03924651
44Vitamin B6 metabolism_Homo sapiens_hsa007501.03166719
45Galactose metabolism_Homo sapiens_hsa000521.01398500
46mRNA surveillance pathway_Homo sapiens_hsa030151.00688994
47Hepatitis B_Homo sapiens_hsa051610.99830355
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99758768
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99309315
50AMPK signaling pathway_Homo sapiens_hsa041520.99002567
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98985920
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98350770
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94049307
54HTLV-I infection_Homo sapiens_hsa051660.93869669
55Proteoglycans in cancer_Homo sapiens_hsa052050.91228438
56Focal adhesion_Homo sapiens_hsa045100.89508416
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88558343
58Adherens junction_Homo sapiens_hsa045200.88303599
59Hepatitis C_Homo sapiens_hsa051600.87931041
60Prolactin signaling pathway_Homo sapiens_hsa049170.84804586
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84376533
62Systemic lupus erythematosus_Homo sapiens_hsa053220.83255218
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79794363
64Choline metabolism in cancer_Homo sapiens_hsa052310.77930789
65Carbon metabolism_Homo sapiens_hsa012000.74770096
66Basal cell carcinoma_Homo sapiens_hsa052170.74355452
67Alcoholism_Homo sapiens_hsa050340.73773594
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73434214
69HIF-1 signaling pathway_Homo sapiens_hsa040660.72258742
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.71086680
71GnRH signaling pathway_Homo sapiens_hsa049120.70922034
72TNF signaling pathway_Homo sapiens_hsa046680.70226346
73Estrogen signaling pathway_Homo sapiens_hsa049150.69696677
74Melanoma_Homo sapiens_hsa052180.68661179
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.68591661
76p53 signaling pathway_Homo sapiens_hsa041150.68084402
77Mismatch repair_Homo sapiens_hsa034300.67772837
78Epstein-Barr virus infection_Homo sapiens_hsa051690.67459733
79Insulin resistance_Homo sapiens_hsa049310.66857878
80Inositol phosphate metabolism_Homo sapiens_hsa005620.66276975
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.65876282
82Influenza A_Homo sapiens_hsa051640.64550096
83RNA transport_Homo sapiens_hsa030130.61200147
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.61196937
85Pathways in cancer_Homo sapiens_hsa052000.61122235
86Shigellosis_Homo sapiens_hsa051310.60726368
87Herpes simplex infection_Homo sapiens_hsa051680.59756651
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59707424
89Hippo signaling pathway_Homo sapiens_hsa043900.58744504
90Amoebiasis_Homo sapiens_hsa051460.58587090
91One carbon pool by folate_Homo sapiens_hsa006700.55358354
92Pyrimidine metabolism_Homo sapiens_hsa002400.54302856
93Vibrio cholerae infection_Homo sapiens_hsa051100.54257857
94FoxO signaling pathway_Homo sapiens_hsa040680.54002166
95N-Glycan biosynthesis_Homo sapiens_hsa005100.53606354
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52883080
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52335921
98ECM-receptor interaction_Homo sapiens_hsa045120.51883932
99Osteoclast differentiation_Homo sapiens_hsa043800.51022242
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.50583568

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