ZNF284

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.47665238
2water-soluble vitamin biosynthetic process (GO:0042364)4.34204007
3behavioral response to nicotine (GO:0035095)4.09571079
4DNA double-strand break processing (GO:0000729)3.93583735
5limb bud formation (GO:0060174)3.77374805
6kidney morphogenesis (GO:0060993)3.64536237
7DNA deamination (GO:0045006)3.63815778
8neural tube formation (GO:0001841)3.60361579
9replication fork processing (GO:0031297)3.58089982
10sulfation (GO:0051923)3.56441811
11regulation of nuclear cell cycle DNA replication (GO:0033262)3.56278685
12indole-containing compound catabolic process (GO:0042436)3.54844777
13indolalkylamine catabolic process (GO:0046218)3.54844777
14tryptophan catabolic process (GO:0006569)3.54844777
15indolalkylamine metabolic process (GO:0006586)3.53787771
16intraciliary transport (GO:0042073)3.48650054
17protein localization to cilium (GO:0061512)3.42358684
18somite development (GO:0061053)3.39787386
19tryptophan metabolic process (GO:0006568)3.36019428
20regulation of meiosis I (GO:0060631)3.34901408
21presynaptic membrane assembly (GO:0097105)3.34875411
22protein polyglutamylation (GO:0018095)3.29387180
23kynurenine metabolic process (GO:0070189)3.29356632
24regulation of non-canonical Wnt signaling pathway (GO:2000050)3.20191128
25preassembly of GPI anchor in ER membrane (GO:0016254)3.10876226
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.09210121
27recombinational repair (GO:0000725)3.00191007
28double-strand break repair via homologous recombination (GO:0000724)2.99424622
29negative regulation of transcription regulatory region DNA binding (GO:2000678)2.97030851
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96233048
31cornea development in camera-type eye (GO:0061303)2.94917973
32protein complex biogenesis (GO:0070271)2.94687651
33fucose catabolic process (GO:0019317)2.93494117
34L-fucose metabolic process (GO:0042354)2.93494117
35L-fucose catabolic process (GO:0042355)2.93494117
36pyrimidine nucleobase catabolic process (GO:0006208)2.93085512
37embryonic epithelial tube formation (GO:0001838)2.91897366
38gamma-aminobutyric acid transport (GO:0015812)2.90845117
39neuronal action potential (GO:0019228)2.89582907
40detection of light stimulus involved in visual perception (GO:0050908)2.88437797
41detection of light stimulus involved in sensory perception (GO:0050962)2.88437797
42presynaptic membrane organization (GO:0097090)2.86298905
43nonmotile primary cilium assembly (GO:0035058)2.86252328
44cell proliferation in forebrain (GO:0021846)2.86093255
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86027026
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.86027026
47NADH dehydrogenase complex assembly (GO:0010257)2.86027026
48negative regulation of telomere maintenance (GO:0032205)2.85554444
49regulation of glucokinase activity (GO:0033131)2.81728531
50regulation of hexokinase activity (GO:1903299)2.81728531
51behavioral response to ethanol (GO:0048149)2.80983567
52synapsis (GO:0007129)2.80592398
53mitochondrial respiratory chain complex assembly (GO:0033108)2.79654312
54somatic hypermutation of immunoglobulin genes (GO:0016446)2.78929071
55somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78929071
56axoneme assembly (GO:0035082)2.73143165
57positive regulation of meiosis (GO:0045836)2.72695278
58respiratory chain complex IV assembly (GO:0008535)2.71645094
59epithelial tube formation (GO:0072175)2.71080173
60positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.68241555
61platelet dense granule organization (GO:0060155)2.67106247
62indole-containing compound metabolic process (GO:0042430)2.66174084
63protein K11-linked deubiquitination (GO:0035871)2.65076135
64cilium morphogenesis (GO:0060271)2.64489377
65piRNA metabolic process (GO:0034587)2.63922543
66negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.60145374
67negative regulation of mast cell activation (GO:0033004)2.58822127
68cilium organization (GO:0044782)2.58752483
69retinal cone cell development (GO:0046549)2.58413105
70reciprocal meiotic recombination (GO:0007131)2.56814239
71reciprocal DNA recombination (GO:0035825)2.56814239
72nucleobase catabolic process (GO:0046113)2.55720105
73regulation of mesoderm development (GO:2000380)2.54272458
74regulation of telomere maintenance (GO:0032204)2.53924788
75prenylation (GO:0097354)2.53775839
76protein prenylation (GO:0018342)2.53775839
77positive regulation of cAMP-mediated signaling (GO:0043950)2.52188216
78positive regulation of meiotic cell cycle (GO:0051446)2.51896322
79startle response (GO:0001964)2.51571075
80photoreceptor cell maintenance (GO:0045494)2.50754575
81cilium assembly (GO:0042384)2.50486276
82amine catabolic process (GO:0009310)2.49973419
83cellular biogenic amine catabolic process (GO:0042402)2.49973419
84spinal cord motor neuron differentiation (GO:0021522)2.49481170
85regulation of DNA endoreduplication (GO:0032875)2.48935819
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48745971
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48343842
88glycosphingolipid biosynthetic process (GO:0006688)2.48266931
89ketone body metabolic process (GO:1902224)2.47794753
90protein K6-linked ubiquitination (GO:0085020)2.47493168
91mannosylation (GO:0097502)2.47475318
92reflex (GO:0060004)2.47114253
93keratinocyte development (GO:0003334)2.46334849
94DNA methylation involved in gamete generation (GO:0043046)2.44125992
95regulation of collateral sprouting (GO:0048670)2.42591731
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42370152
97retinal ganglion cell axon guidance (GO:0031290)2.41768155
98cytochrome complex assembly (GO:0017004)2.41639867
99isotype switching (GO:0045190)2.41639847
100somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41639847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.59535251
2GBX2_23144817_ChIP-Seq_PC3_Human3.29513552
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88976812
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85208193
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59530656
6IGF1R_20145208_ChIP-Seq_DFB_Human2.57850905
7VDR_22108803_ChIP-Seq_LS180_Human2.56916993
8FUS_26573619_Chip-Seq_HEK293_Human2.53024357
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52412780
10EWS_26573619_Chip-Seq_HEK293_Human2.43935503
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39094723
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.28669801
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25287584
14P300_19829295_ChIP-Seq_ESCs_Human2.19153377
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12781612
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.11723925
17EZH2_22144423_ChIP-Seq_EOC_Human2.05959357
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03921003
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00577072
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97278357
21TAF15_26573619_Chip-Seq_HEK293_Human1.97080495
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96761970
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90925814
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84491206
25ER_23166858_ChIP-Seq_MCF-7_Human1.80363487
26BCAT_22108803_ChIP-Seq_LS180_Human1.71353355
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68367195
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66845390
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64952852
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.59454491
31SMAD4_21799915_ChIP-Seq_A2780_Human1.59336009
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.56602314
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56541831
34* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55826588
35STAT3_23295773_ChIP-Seq_U87_Human1.55764125
36AR_25329375_ChIP-Seq_VCAP_Human1.54453639
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.53905640
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.52404631
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52182397
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50193628
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49790328
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48639408
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47710124
44MYC_18940864_ChIP-ChIP_HL60_Human1.46658957
45CBP_20019798_ChIP-Seq_JUKART_Human1.46580933
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46580933
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44563788
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44357844
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43777780
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43777780
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42460692
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42369642
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.41998466
54IRF1_19129219_ChIP-ChIP_H3396_Human1.41013397
55TCF4_23295773_ChIP-Seq_U87_Human1.39850920
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.39642537
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37931559
58ELK1_19687146_ChIP-ChIP_HELA_Human1.37664055
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32363616
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30864710
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.30792839
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28236138
63RNF2_27304074_Chip-Seq_NSC_Mouse1.27494611
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.27424625
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26445137
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.26338542
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25761191
68RUNX2_22187159_ChIP-Seq_PCA_Human1.25441014
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25434264
70TCF4_22108803_ChIP-Seq_LS180_Human1.25366989
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21344797
72NANOG_19829295_ChIP-Seq_ESCs_Human1.20359841
73SOX2_19829295_ChIP-Seq_ESCs_Human1.20359841
74TP53_22573176_ChIP-Seq_HFKS_Human1.18907639
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16784538
76P53_22387025_ChIP-Seq_ESCs_Mouse1.16475268
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15884058
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.14895907
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.14766978
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14145247
81* SMAD4_21741376_ChIP-Seq_EPCs_Human1.12181495
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11930059
83REST_21632747_ChIP-Seq_MESCs_Mouse1.08964072
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.08528568
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08528568
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05686753
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05522794
88TP53_16413492_ChIP-PET_HCT116_Human1.04885592
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.04697003
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03974407
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.02515485
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01834825
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.00888121
94CDX2_22108803_ChIP-Seq_LS180_Human1.00263934
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99855764
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99569358
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98205628
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97503687
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97061514
100NCOR_22424771_ChIP-Seq_293T_Human0.96886117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.69279738
2MP0000372_irregular_coat_pigmentation2.92075236
3MP0008877_abnormal_DNA_methylation2.88711504
4MP0003195_calcinosis2.72781388
5MP0002653_abnormal_ependyma_morphology2.39302877
6MP0006292_abnormal_olfactory_placode2.37584744
7MP0003787_abnormal_imprinting2.37521886
8MP0000569_abnormal_digit_pigmentation2.34930866
9MP0002736_abnormal_nociception_after2.34777864
10MP0001968_abnormal_touch/_nociception2.22633463
11MP0009697_abnormal_copulation2.04335022
12MP0006072_abnormal_retinal_apoptosis2.03976316
13MP0005551_abnormal_eye_electrophysiolog1.98824444
14MP0003121_genomic_imprinting1.92319139
15MP0004043_abnormal_pH_regulation1.83731011
16MP0009046_muscle_twitch1.83364914
17MP0003136_yellow_coat_color1.81244798
18MP0002938_white_spotting1.78327613
19MP0008057_abnormal_DNA_replication1.73634137
20MP0002163_abnormal_gland_morphology1.73071417
21MP0003880_abnormal_central_pattern1.69585770
22MP0000631_abnormal_neuroendocrine_gland1.67667458
23MP0005253_abnormal_eye_physiology1.66229168
24MP0008872_abnormal_physiological_respon1.65773991
25MP0005171_absent_coat_pigmentation1.63058247
26MP0003122_maternal_imprinting1.62210801
27MP0004885_abnormal_endolymph1.60324615
28MP0008058_abnormal_DNA_repair1.60204740
29MP0005646_abnormal_pituitary_gland1.58826086
30MP0005174_abnormal_tail_pigmentation1.55370068
31MP0001984_abnormal_olfaction1.50998400
32MP0005379_endocrine/exocrine_gland_phen1.50466018
33MP0008789_abnormal_olfactory_epithelium1.49580144
34MP0006276_abnormal_autonomic_nervous1.48345217
35MP0002751_abnormal_autonomic_nervous1.45324616
36MP0009745_abnormal_behavioral_response1.44290312
37MP0002272_abnormal_nervous_system1.43764826
38MP0005075_abnormal_melanosome_morpholog1.42335513
39MP0004133_heterotaxia1.41081437
40MP0003646_muscle_fatigue1.39999004
41MP0005645_abnormal_hypothalamus_physiol1.39815545
42MP0001485_abnormal_pinna_reflex1.38822622
43MP0002876_abnormal_thyroid_physiology1.37271324
44MP0005084_abnormal_gallbladder_morpholo1.37196898
45MP0001188_hyperpigmentation1.36350516
46MP0005367_renal/urinary_system_phenotyp1.32501773
47MP0000516_abnormal_urinary_system1.32501773
48MP0001486_abnormal_startle_reflex1.30522981
49MP0004142_abnormal_muscle_tone1.30256748
50MP0005389_reproductive_system_phenotype1.30252668
51MP0002638_abnormal_pupillary_reflex1.29280643
52MP0002928_abnormal_bile_duct1.27220495
53MP0003283_abnormal_digestive_organ1.26809508
54MP0003119_abnormal_digestive_system1.25227736
55MP0000427_abnormal_hair_cycle1.22454256
56MP0005386_behavior/neurological_phenoty1.18933157
57MP0004924_abnormal_behavior1.18933157
58MP0003718_maternal_effect1.17724207
59MP0002160_abnormal_reproductive_system1.15524418
60MP0002837_dystrophic_cardiac_calcinosis1.15203135
61MP0003011_delayed_dark_adaptation1.13603050
62MP0001529_abnormal_vocalization1.13269176
63MP0002138_abnormal_hepatobiliary_system1.12426329
64MP0002277_abnormal_respiratory_mucosa1.12110074
65MP0002557_abnormal_social/conspecific_i1.10743041
66MP0002734_abnormal_mechanical_nocicepti1.10469861
67MP0001986_abnormal_taste_sensitivity1.10256350
68MP0000015_abnormal_ear_pigmentation1.09402956
69MP0001919_abnormal_reproductive_system1.08255512
70MP0000049_abnormal_middle_ear1.06950062
71MP0002095_abnormal_skin_pigmentation1.00988499
72MP0005394_taste/olfaction_phenotype0.99230420
73MP0005499_abnormal_olfactory_system0.99230420
74MP0003937_abnormal_limbs/digits/tail_de0.97583739
75MP0002572_abnormal_emotion/affect_behav0.97002484
76MP0001970_abnormal_pain_threshold0.95008657
77MP0002735_abnormal_chemical_nociception0.94876362
78MP0002064_seizures0.94872722
79MP0005195_abnormal_posterior_eye0.93876355
80MP0001293_anophthalmia0.93484888
81MP0002234_abnormal_pharynx_morphology0.93149340
82MP0003567_abnormal_fetal_cardiomyocyte0.90943942
83MP0008875_abnormal_xenobiotic_pharmacok0.89872345
84MP0000383_abnormal_hair_follicle0.88541607
85MP0003635_abnormal_synaptic_transmissio0.88166030
86MP0010094_abnormal_chromosome_stability0.87376064
87MP0000647_abnormal_sebaceous_gland0.86945562
88MP0002282_abnormal_trachea_morphology0.86865900
89MP0002752_abnormal_somatic_nervous0.83354462
90MP0000613_abnormal_salivary_gland0.82986770
91MP0001324_abnormal_eye_pigmentation0.81925116
92MP0002067_abnormal_sensory_capabilities0.81405289
93MP0005187_abnormal_penis_morphology0.81349687
94MP0001119_abnormal_female_reproductive0.81179985
95MP0002184_abnormal_innervation0.78754262
96MP0004742_abnormal_vestibular_system0.78693520
97MP0000026_abnormal_inner_ear0.77728537
98MP0000653_abnormal_sex_gland0.77224267
99MP0000778_abnormal_nervous_system0.75793729
100MP0004147_increased_porphyrin_level0.75776333

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.85424073
2Pancreatic fibrosis (HP:0100732)3.50285906
3Hyperventilation (HP:0002883)3.48436847
4True hermaphroditism (HP:0010459)3.46997219
5Abolished electroretinogram (ERG) (HP:0000550)3.25915884
6Nephronophthisis (HP:0000090)3.24793078
7Molar tooth sign on MRI (HP:0002419)3.13845259
8Abnormality of midbrain morphology (HP:0002418)3.13845259
9Congenital stationary night blindness (HP:0007642)3.12913335
10Medial flaring of the eyebrow (HP:0010747)2.98885840
11Neoplasm of the adrenal cortex (HP:0100641)2.90210511
12Abnormality of the renal medulla (HP:0100957)2.80617576
13Intestinal atresia (HP:0011100)2.75854037
14Pendular nystagmus (HP:0012043)2.75717709
15Abnormality of the renal cortex (HP:0011035)2.65515746
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.63862593
17Methylmalonic acidemia (HP:0002912)2.49688433
18Abnormality of the ileum (HP:0001549)2.48674374
19Meckel diverticulum (HP:0002245)2.44560779
20Abnormality of chromosome stability (HP:0003220)2.43496863
21Cystic liver disease (HP:0006706)2.43117412
22Attenuation of retinal blood vessels (HP:0007843)2.40761245
23Decreased central vision (HP:0007663)2.39516117
24Gait imbalance (HP:0002141)2.39481541
25Increased corneal curvature (HP:0100692)2.39389804
26Keratoconus (HP:0000563)2.39389804
27Hypothermia (HP:0002045)2.38829233
28Gaze-evoked nystagmus (HP:0000640)2.36169768
29Congenital primary aphakia (HP:0007707)2.35451176
30Congenital sensorineural hearing impairment (HP:0008527)2.34107911
31Abnormality of the labia minora (HP:0012880)2.30397292
32Congenital hepatic fibrosis (HP:0002612)2.25160873
33Postaxial foot polydactyly (HP:0001830)2.24605794
34Large for gestational age (HP:0001520)2.24358259
35Nephrogenic diabetes insipidus (HP:0009806)2.24180290
36Male pseudohermaphroditism (HP:0000037)2.21674974
37Methylmalonic aciduria (HP:0012120)2.20127735
38Thyroiditis (HP:0100646)2.17719994
39Ectopic kidney (HP:0000086)2.12214217
40Genital tract atresia (HP:0001827)2.11497233
41Short 1st metacarpal (HP:0010034)2.10929802
42Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.10929802
43Mesomelia (HP:0003027)2.08681947
44Volvulus (HP:0002580)2.08648823
45Abnormal rod and cone electroretinograms (HP:0008323)2.07191073
46Astigmatism (HP:0000483)2.07087544
47Bile duct proliferation (HP:0001408)2.04281823
48Abnormal biliary tract physiology (HP:0012439)2.04281823
49Vaginal atresia (HP:0000148)2.04239031
50Small hand (HP:0200055)2.03594214
51Hypoplasia of the fovea (HP:0007750)2.02491096
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.02491096
53Median cleft lip (HP:0000161)2.01482923
54Clubbing of toes (HP:0100760)2.01341640
55Bony spicule pigmentary retinopathy (HP:0007737)2.00121613
56Absent thumb (HP:0009777)1.98735549
57Dynein arm defect of respiratory motile cilia (HP:0012255)1.97426796
58Absent/shortened dynein arms (HP:0200106)1.97426796
59Postaxial hand polydactyly (HP:0001162)1.94702527
60Colon cancer (HP:0003003)1.93427008
61Tubular atrophy (HP:0000092)1.91734688
62Type II lissencephaly (HP:0007260)1.91118122
63Sclerocornea (HP:0000647)1.90362837
64Polydipsia (HP:0001959)1.89116645
65Abnormal drinking behavior (HP:0030082)1.89116645
66Furrowed tongue (HP:0000221)1.88112592
67Abnormality of the preputium (HP:0100587)1.87996195
68Progressive inability to walk (HP:0002505)1.87948684
69Preaxial hand polydactyly (HP:0001177)1.86489301
70Broad-based gait (HP:0002136)1.83444209
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.82969587
72Abnormality of the renal collecting system (HP:0004742)1.82767531
73Renal cortical cysts (HP:0000803)1.82690407
74Ependymoma (HP:0002888)1.80973120
75Abnormality of the 1st metacarpal (HP:0010009)1.80566268
76Inability to walk (HP:0002540)1.80275104
77Anencephaly (HP:0002323)1.79839982
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.79323681
79Poor coordination (HP:0002370)1.79185231
80Progressive macrocephaly (HP:0004481)1.79126003
81Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78946313
82Adrenal hypoplasia (HP:0000835)1.78535657
83Acute necrotizing encephalopathy (HP:0006965)1.78425036
84Short foot (HP:0001773)1.78417610
85Glioma (HP:0009733)1.77670493
86Aplasia/hypoplasia of the uterus (HP:0008684)1.76761168
873-Methylglutaconic aciduria (HP:0003535)1.76477349
88Asplenia (HP:0001746)1.75556538
89Hemiparesis (HP:0001269)1.75241098
90Chromsome breakage (HP:0040012)1.74802501
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74003817
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73841504
93Absent speech (HP:0001344)1.73621312
94Sloping forehead (HP:0000340)1.73277486
95Focal seizures (HP:0007359)1.73175373
96Focal motor seizures (HP:0011153)1.72936601
97Hypomagnesemia (HP:0002917)1.69074641
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68739736
99Congenital, generalized hypertrichosis (HP:0004540)1.68679499
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.68650722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.12385861
2NUAK13.51801958
3MAP4K23.12826995
4WNK33.03334239
5BMPR1B2.68432992
6GRK12.33651345
7CASK2.23531874
8TRIM282.21511737
9ADRBK22.20962818
10ZAK2.19478602
11ACVR1B2.11698906
12TNIK2.01390066
13INSRR2.00947071
14FER1.96118475
15MAPK131.89998985
16MKNK21.86602289
17PLK21.77100801
18PINK11.57075243
19WEE11.41675981
20ERBB31.33979689
21PNCK1.33698909
22FES1.33418242
23PLK31.30546231
24MARK11.30438550
25VRK11.28182463
26TAOK31.22220990
27CSNK1G11.20316956
28PRKCE1.18251162
29BRSK21.17859858
30MKNK11.14639484
31LATS11.13253652
32AKT31.10775236
33CSNK1G21.10237160
34MAP3K41.08450470
35CSNK1G31.06302704
36EIF2AK31.04765400
37STK391.03725148
38DYRK20.99853833
39MST40.98369755
40PAK30.96714944
41PLK40.96038549
42VRK20.93723576
43PRKCG0.90579374
44OXSR10.90267307
45CSNK1A1L0.89612525
46WNK40.86535987
47FGFR20.82983378
48BCR0.81949880
49STK30.80637974
50IRAK10.79137262
51TAF10.78578980
52TGFBR10.77703910
53ADRBK10.74528043
54TLK10.67525132
55STK160.67032171
56GRK50.66522922
57TXK0.65701011
58CSNK1A10.65126824
59CDC70.62322160
60CAMK10.61763438
61FLT30.61434081
62PTK2B0.60390517
63EPHA30.60305152
64CAMKK20.59434032
65DAPK20.57625204
66MAPKAPK50.57316510
67BCKDK0.56592513
68MAP2K70.55290493
69PLK10.54435749
70CAMK2A0.52421749
71SGK20.51750554
72NTRK20.48960161
73NTRK30.48874384
74PKN10.48848496
75TSSK60.48023190
76NLK0.47514287
77CSNK1D0.47485165
78PRKCI0.47285496
79TIE10.47112054
80ATM0.46067695
81ATR0.45462614
82RPS6KA50.42510125
83SRPK10.41237400
84CHEK20.40686007
85PRKACA0.39736404
86PRKCQ0.38305368
87BUB10.37992568
88DYRK30.37102958
89CDK30.36546437
90EIF2AK20.36471437
91LMTK20.34713448
92GRK70.34282825
93NEK10.34014297
94PIK3CA0.33407827
95NME10.32876317
96PRKG10.32531671
97EIF2AK10.32107439
98MAP2K10.30830112
99IKBKB0.29984427
100KIT0.29773807

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.03568185
2Homologous recombination_Homo sapiens_hsa034402.53347588
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.52899995
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41727653
5Phototransduction_Homo sapiens_hsa047442.34976169
6Protein export_Homo sapiens_hsa030602.27070657
7Non-homologous end-joining_Homo sapiens_hsa034502.24665947
8Fanconi anemia pathway_Homo sapiens_hsa034602.20634701
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10815376
10Selenocompound metabolism_Homo sapiens_hsa004502.04801882
11Nicotine addiction_Homo sapiens_hsa050331.96293281
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92011889
13Propanoate metabolism_Homo sapiens_hsa006401.90984717
14Ether lipid metabolism_Homo sapiens_hsa005651.84034268
15Basal transcription factors_Homo sapiens_hsa030221.81966752
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81702688
17Linoleic acid metabolism_Homo sapiens_hsa005911.79016904
18Caffeine metabolism_Homo sapiens_hsa002321.78745294
19Butanoate metabolism_Homo sapiens_hsa006501.74901755
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72884346
21RNA polymerase_Homo sapiens_hsa030201.72629231
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71218432
23Nitrogen metabolism_Homo sapiens_hsa009101.69456675
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67166743
25Tryptophan metabolism_Homo sapiens_hsa003801.61939496
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56910912
27RNA degradation_Homo sapiens_hsa030181.52956080
28Chemical carcinogenesis_Homo sapiens_hsa052041.52304271
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48606236
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48359832
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42547517
32Oxidative phosphorylation_Homo sapiens_hsa001901.39607510
33Proteasome_Homo sapiens_hsa030501.30687288
34Retinol metabolism_Homo sapiens_hsa008301.26593645
35Olfactory transduction_Homo sapiens_hsa047401.19386071
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.18922095
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14773040
38Parkinsons disease_Homo sapiens_hsa050121.13648566
39Peroxisome_Homo sapiens_hsa041461.13605965
40Sulfur metabolism_Homo sapiens_hsa009201.13591096
41Insulin secretion_Homo sapiens_hsa049111.13474223
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08631159
43Taste transduction_Homo sapiens_hsa047421.07981000
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06327279
45Steroid biosynthesis_Homo sapiens_hsa001001.03722383
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02318859
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01886125
48One carbon pool by folate_Homo sapiens_hsa006701.00826307
49Hedgehog signaling pathway_Homo sapiens_hsa043400.97889618
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97859086
51beta-Alanine metabolism_Homo sapiens_hsa004100.93056438
52Glycerolipid metabolism_Homo sapiens_hsa005610.89130558
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.88059598
54Morphine addiction_Homo sapiens_hsa050320.85638511
55GABAergic synapse_Homo sapiens_hsa047270.84269873
56Arachidonic acid metabolism_Homo sapiens_hsa005900.83688547
57Mismatch repair_Homo sapiens_hsa034300.77546181
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.77232713
59ABC transporters_Homo sapiens_hsa020100.74962222
60Fatty acid elongation_Homo sapiens_hsa000620.74375428
61Histidine metabolism_Homo sapiens_hsa003400.74263847
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71082473
63Huntingtons disease_Homo sapiens_hsa050160.70253642
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68783243
65Circadian entrainment_Homo sapiens_hsa047130.68273740
66Serotonergic synapse_Homo sapiens_hsa047260.68042743
67Alzheimers disease_Homo sapiens_hsa050100.65364923
68Basal cell carcinoma_Homo sapiens_hsa052170.64856800
69Collecting duct acid secretion_Homo sapiens_hsa049660.64841996
70Regulation of autophagy_Homo sapiens_hsa041400.63030491
71Fatty acid degradation_Homo sapiens_hsa000710.63005010
72Glutamatergic synapse_Homo sapiens_hsa047240.62408891
73RNA transport_Homo sapiens_hsa030130.61944214
74Purine metabolism_Homo sapiens_hsa002300.61160653
75Metabolic pathways_Homo sapiens_hsa011000.59696289
76Salivary secretion_Homo sapiens_hsa049700.59295662
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59153554
78Ovarian steroidogenesis_Homo sapiens_hsa049130.55706003
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53944801
80Lysine degradation_Homo sapiens_hsa003100.52646923
81Calcium signaling pathway_Homo sapiens_hsa040200.50537874
82Dorso-ventral axis formation_Homo sapiens_hsa043200.50126221
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49666046
84p53 signaling pathway_Homo sapiens_hsa041150.49035221
85Dopaminergic synapse_Homo sapiens_hsa047280.48868020
86Nucleotide excision repair_Homo sapiens_hsa034200.47492837
87Long-term depression_Homo sapiens_hsa047300.44743774
88TGF-beta signaling pathway_Homo sapiens_hsa043500.44637190
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.43725871
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43115007
91Fat digestion and absorption_Homo sapiens_hsa049750.41660537
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.40877663
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40792473
94Starch and sucrose metabolism_Homo sapiens_hsa005000.38943899
95Pyrimidine metabolism_Homo sapiens_hsa002400.38322729
96Cocaine addiction_Homo sapiens_hsa050300.36556360
97Vitamin digestion and absorption_Homo sapiens_hsa049770.36252772
98Glutathione metabolism_Homo sapiens_hsa004800.34634777
99Mineral absorption_Homo sapiens_hsa049780.34423749
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34164329

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