ZNF285

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.95339597
2piRNA metabolic process (GO:0034587)4.10562547
3protein polyglutamylation (GO:0018095)4.03377613
4pyrimidine nucleobase catabolic process (GO:0006208)3.86167340
5gamma-aminobutyric acid transport (GO:0015812)3.77414487
6negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60698851
7water-soluble vitamin biosynthetic process (GO:0042364)3.41849159
8protein K11-linked deubiquitination (GO:0035871)3.28926119
9neural tube formation (GO:0001841)3.26373456
10nucleobase catabolic process (GO:0046113)3.23695738
11negative regulation of transcription regulatory region DNA binding (GO:2000678)3.22801114
12DNA methylation involved in gamete generation (GO:0043046)3.21614614
13cornea development in camera-type eye (GO:0061303)3.05944868
14presynaptic membrane assembly (GO:0097105)3.04984653
15positive regulation of amino acid transport (GO:0051957)3.01313249
16startle response (GO:0001964)2.99369947
17response to pheromone (GO:0019236)2.99300372
18NADH dehydrogenase complex assembly (GO:0010257)2.99022722
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99022722
20mitochondrial respiratory chain complex I assembly (GO:0032981)2.99022722
21regulation of action potential (GO:0098900)2.98272910
22negative regulation of telomere maintenance (GO:0032205)2.98236298
23positive regulation of oligodendrocyte differentiation (GO:0048714)2.98068207
24sulfation (GO:0051923)2.97798478
25serotonin receptor signaling pathway (GO:0007210)2.97668575
26negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96723880
27indolalkylamine metabolic process (GO:0006586)2.95601511
28axoneme assembly (GO:0035082)2.95120182
29retinal cone cell development (GO:0046549)2.93129712
30somite development (GO:0061053)2.90662212
31platelet dense granule organization (GO:0060155)2.90420441
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89959418
33parturition (GO:0007567)2.89908851
34seminiferous tubule development (GO:0072520)2.89525654
35detection of light stimulus involved in visual perception (GO:0050908)2.89022633
36detection of light stimulus involved in sensory perception (GO:0050962)2.89022633
37protein complex biogenesis (GO:0070271)2.87805608
38regulation of meiosis I (GO:0060631)2.87799139
39L-fucose catabolic process (GO:0042355)2.87518031
40fucose catabolic process (GO:0019317)2.87518031
41L-fucose metabolic process (GO:0042354)2.87518031
42negative regulation of mast cell activation (GO:0033004)2.87271358
43tryptophan catabolic process (GO:0006569)2.85781323
44indole-containing compound catabolic process (GO:0042436)2.85781323
45indolalkylamine catabolic process (GO:0046218)2.85781323
46epithelial cilium movement (GO:0003351)2.85125078
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84426451
48behavioral response to ethanol (GO:0048149)2.83390884
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82130538
50cell proliferation in forebrain (GO:0021846)2.81484114
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81000896
52cellular ketone body metabolic process (GO:0046950)2.78577634
53head development (GO:0060322)2.73535150
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72774331
55transmission of nerve impulse (GO:0019226)2.69098838
56DNA deamination (GO:0045006)2.68654595
57neuronal action potential (GO:0019228)2.68132284
58nonmotile primary cilium assembly (GO:0035058)2.66785512
59reflex (GO:0060004)2.65104275
60presynaptic membrane organization (GO:0097090)2.65071798
61positive regulation of meiosis (GO:0045836)2.64565794
62kynurenine metabolic process (GO:0070189)2.61811220
63indole-containing compound metabolic process (GO:0042430)2.61164034
64serotonin metabolic process (GO:0042428)2.61132292
65mitochondrial respiratory chain complex assembly (GO:0033108)2.61100408
66tryptophan metabolic process (GO:0006568)2.60926004
67resolution of meiotic recombination intermediates (GO:0000712)2.60138915
68cellular response to ATP (GO:0071318)2.57916691
69photoreceptor cell development (GO:0042461)2.56272150
70positive regulation of catecholamine secretion (GO:0033605)2.55624028
71cullin deneddylation (GO:0010388)2.55390022
72photoreceptor cell maintenance (GO:0045494)2.54886205
73primary amino compound metabolic process (GO:1901160)2.53727678
74neuron cell-cell adhesion (GO:0007158)2.51739316
75cilium morphogenesis (GO:0060271)2.50687843
76regulation of hexokinase activity (GO:1903299)2.50287096
77regulation of glucokinase activity (GO:0033131)2.50287096
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49632181
79DNA double-strand break processing (GO:0000729)2.49262855
80protein-cofactor linkage (GO:0018065)2.48234506
81embryonic epithelial tube formation (GO:0001838)2.47233347
82ketone body metabolic process (GO:1902224)2.46520215
83regulation of collateral sprouting (GO:0048670)2.45544990
84synaptic transmission, glutamatergic (GO:0035249)2.44893715
85regulation of male gonad development (GO:2000018)2.44733866
86otic vesicle formation (GO:0030916)2.44001792
87negative regulation of appetite (GO:0032099)2.43830564
88negative regulation of response to food (GO:0032096)2.43830564
89positive regulation of meiotic cell cycle (GO:0051446)2.43662512
90positive regulation of mitochondrial fission (GO:0090141)2.43055030
91adaptation of signaling pathway (GO:0023058)2.41795385
92cilium organization (GO:0044782)2.41113059
93intraciliary transport (GO:0042073)2.41084855
94male meiosis I (GO:0007141)2.40336044
95L-methionine salvage (GO:0071267)2.38594271
96L-methionine biosynthetic process (GO:0071265)2.38594271
97amino acid salvage (GO:0043102)2.38594271
98synapsis (GO:0007129)2.36558793
99protein deneddylation (GO:0000338)2.36531505
100aggressive behavior (GO:0002118)2.35909410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.59099739
2GBX2_23144817_ChIP-Seq_PC3_Human3.58274075
3ZNF274_21170338_ChIP-Seq_K562_Hela3.47726061
4IGF1R_20145208_ChIP-Seq_DFB_Human3.14401751
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85585964
6VDR_22108803_ChIP-Seq_LS180_Human2.66207003
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60007495
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48201132
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31563078
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29279991
11TAF15_26573619_Chip-Seq_HEK293_Human2.25501772
12FUS_26573619_Chip-Seq_HEK293_Human2.23387426
13EWS_26573619_Chip-Seq_HEK293_Human2.21246286
14P300_19829295_ChIP-Seq_ESCs_Human2.08941263
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01833368
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00749057
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96205064
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89216487
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.87157592
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83675126
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.79298080
22RNF2_27304074_Chip-Seq_NSC_Mouse1.73161412
23SMAD4_21799915_ChIP-Seq_A2780_Human1.70485579
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69288245
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69116291
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68851906
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67959779
28ER_23166858_ChIP-Seq_MCF-7_Human1.67939341
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63332983
30IRF1_19129219_ChIP-ChIP_H3396_Human1.61281174
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60828605
32REST_21632747_ChIP-Seq_MESCs_Mouse1.57219384
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.56710150
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56187915
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56012879
36CBP_20019798_ChIP-Seq_JUKART_Human1.56012879
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55676210
38STAT3_23295773_ChIP-Seq_U87_Human1.55494613
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54797502
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49828692
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49607042
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48962062
43AR_25329375_ChIP-Seq_VCAP_Human1.48330552
44BCAT_22108803_ChIP-Seq_LS180_Human1.48247821
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47454520
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47410624
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46563024
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.45438297
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.43432264
50TP53_22573176_ChIP-Seq_HFKS_Human1.41649026
51TCF4_23295773_ChIP-Seq_U87_Human1.40584355
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40221277
53MYC_18940864_ChIP-ChIP_HL60_Human1.36680801
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33665707
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32598474
56RUNX2_22187159_ChIP-Seq_PCA_Human1.28641594
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27588176
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26515708
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.25269704
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.24946562
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.22506581
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.22462349
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22185054
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.21480019
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21373548
66NANOG_19829295_ChIP-Seq_ESCs_Human1.18837238
67SOX2_19829295_ChIP-Seq_ESCs_Human1.18837238
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.17307465
69TCF4_22108803_ChIP-Seq_LS180_Human1.17173770
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16466765
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16466765
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.15859216
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15391354
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14533988
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.14476864
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14236230
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13579437
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12992765
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.12281157
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.11249914
81P53_22387025_ChIP-Seq_ESCs_Mouse1.10236586
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.08949582
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.08744920
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08309710
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08172126
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.05792220
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05792220
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04356090
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03848033
90AR_21572438_ChIP-Seq_LNCaP_Human1.03628646
91NCOR_22424771_ChIP-Seq_293T_Human1.02052859
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00137492
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.99822084
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.99730487
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99329152
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98728075
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98240138
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96578655
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.96185762
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95762933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.15608182
2MP0002102_abnormal_ear_morphology2.69755369
3MP0006292_abnormal_olfactory_placode2.53115142
4MP0001968_abnormal_touch/_nociception2.46521361
5MP0003787_abnormal_imprinting2.43507051
6MP0002736_abnormal_nociception_after2.20948383
7MP0005646_abnormal_pituitary_gland2.18955782
8MP0005551_abnormal_eye_electrophysiolog2.17698197
9MP0003880_abnormal_central_pattern2.10936758
10MP0009745_abnormal_behavioral_response2.06452102
11MP0006276_abnormal_autonomic_nervous2.04753598
12MP0009046_muscle_twitch2.01363267
13MP0002272_abnormal_nervous_system1.98622863
14MP0001984_abnormal_olfaction1.93902030
15MP0002160_abnormal_reproductive_system1.89323483
16MP0002735_abnormal_chemical_nociception1.84656860
17MP0006072_abnormal_retinal_apoptosis1.84127941
18MP0002837_dystrophic_cardiac_calcinosis1.80495202
19MP0001529_abnormal_vocalization1.79412923
20MP0003195_calcinosis1.76862764
21MP0001486_abnormal_startle_reflex1.75971212
22MP0004885_abnormal_endolymph1.75245063
23MP0000631_abnormal_neuroendocrine_gland1.70682411
24MP0005389_reproductive_system_phenotype1.68112931
25MP0000049_abnormal_middle_ear1.66622705
26MP0005253_abnormal_eye_physiology1.65518627
27MP0004142_abnormal_muscle_tone1.62982912
28MP0003121_genomic_imprinting1.62157894
29MP0001986_abnormal_taste_sensitivity1.60008669
30MP0003122_maternal_imprinting1.57343934
31MP0002234_abnormal_pharynx_morphology1.52425883
32MP0005645_abnormal_hypothalamus_physiol1.52311254
33MP0003635_abnormal_synaptic_transmissio1.51670668
34MP0002572_abnormal_emotion/affect_behav1.49358568
35MP0002064_seizures1.48223557
36MP0001485_abnormal_pinna_reflex1.48186534
37MP0003646_muscle_fatigue1.47569347
38MP0004270_analgesia1.45201048
39MP0004133_heterotaxia1.44330491
40MP0002638_abnormal_pupillary_reflex1.43999618
41MP0000778_abnormal_nervous_system1.41328556
42MP0002063_abnormal_learning/memory/cond1.40206128
43MP0002734_abnormal_mechanical_nocicepti1.38793672
44MP0002557_abnormal_social/conspecific_i1.35339335
45MP0004859_abnormal_synaptic_plasticity1.33985813
46MP0004145_abnormal_muscle_electrophysio1.33070783
47MP0005084_abnormal_gallbladder_morpholo1.32169064
48MP0001501_abnormal_sleep_pattern1.31595589
49MP0008995_early_reproductive_senescence1.31036330
50MP0008872_abnormal_physiological_respon1.29887176
51MP0001970_abnormal_pain_threshold1.29783688
52MP0001919_abnormal_reproductive_system1.28217928
53MP0002138_abnormal_hepatobiliary_system1.24384800
54MP0002733_abnormal_thermal_nociception1.24055102
55MP0003718_maternal_effect1.23927649
56MP0003011_delayed_dark_adaptation1.23143208
57MP0003119_abnormal_digestive_system1.22742617
58MP0004215_abnormal_myocardial_fiber1.21130529
59MP0008789_abnormal_olfactory_epithelium1.20056653
60MP0002928_abnormal_bile_duct1.17906563
61MP0002876_abnormal_thyroid_physiology1.14397483
62MP0002653_abnormal_ependyma_morphology1.14299832
63MP0004147_increased_porphyrin_level1.13210008
64MP0002822_catalepsy1.12090768
65MP0010386_abnormal_urinary_bladder1.11906884
66MP0002751_abnormal_autonomic_nervous1.11400351
67MP0005499_abnormal_olfactory_system1.09528017
68MP0005394_taste/olfaction_phenotype1.09528017
69MP0005386_behavior/neurological_phenoty1.08407455
70MP0004924_abnormal_behavior1.08407455
71MP0005410_abnormal_fertilization1.06925912
72MP0002067_abnormal_sensory_capabilities1.05326849
73MP0003890_abnormal_embryonic-extraembry1.04231430
74MP0000372_irregular_coat_pigmentation1.03344428
75MP0002184_abnormal_innervation1.02500839
76MP0000427_abnormal_hair_cycle1.01659846
77MP0005195_abnormal_posterior_eye1.00799236
78MP0002909_abnormal_adrenal_gland0.99877217
79MP0003136_yellow_coat_color0.99472099
80MP0001905_abnormal_dopamine_level0.98337629
81MP0008058_abnormal_DNA_repair0.97906153
82MP0003937_abnormal_limbs/digits/tail_de0.97582842
83MP0002752_abnormal_somatic_nervous0.96539738
84MP0003698_abnormal_male_reproductive0.96302751
85MP0008875_abnormal_xenobiotic_pharmacok0.96248681
86MP0002163_abnormal_gland_morphology0.96068919
87MP0003567_abnormal_fetal_cardiomyocyte0.94944141
88MP0002938_white_spotting0.93951756
89MP0001963_abnormal_hearing_physiology0.93943393
90MP0002210_abnormal_sex_determination0.93871506
91MP0004043_abnormal_pH_regulation0.93205548
92MP0005423_abnormal_somatic_nervous0.92796298
93MP0001929_abnormal_gametogenesis0.91393913
94MP0001188_hyperpigmentation0.90856920
95MP0002229_neurodegeneration0.90078114
96MP0005379_endocrine/exocrine_gland_phen0.89078193
97MP0002882_abnormal_neuron_morphology0.88892936
98MP0008961_abnormal_basal_metabolism0.86864055
99MP0000653_abnormal_sex_gland0.86054103
100MP0003938_abnormal_ear_development0.85907549

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.31139719
2Pancreatic cysts (HP:0001737)3.90199979
3Pancreatic fibrosis (HP:0100732)3.62755884
4Abnormality of midbrain morphology (HP:0002418)3.47745878
5Molar tooth sign on MRI (HP:0002419)3.47745878
6Nephronophthisis (HP:0000090)3.39615110
7Congenital stationary night blindness (HP:0007642)3.30922340
8Hyperventilation (HP:0002883)3.19992387
9Pendular nystagmus (HP:0012043)3.17267973
10Medial flaring of the eyebrow (HP:0010747)3.10397892
11Abolished electroretinogram (ERG) (HP:0000550)2.98835794
12Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97771954
13Methylmalonic acidemia (HP:0002912)2.94937591
14Abnormal rod and cone electroretinograms (HP:0008323)2.90966448
15Attenuation of retinal blood vessels (HP:0007843)2.82327776
16Abnormality of the renal medulla (HP:0100957)2.82015964
17Gait imbalance (HP:0002141)2.59830443
18Abnormality of the labia minora (HP:0012880)2.54990808
19Increased corneal curvature (HP:0100692)2.48041468
20Keratoconus (HP:0000563)2.48041468
21Chronic hepatic failure (HP:0100626)2.47418535
22Abnormality of the renal cortex (HP:0011035)2.47215273
23Congenital primary aphakia (HP:0007707)2.46862709
24Male pseudohermaphroditism (HP:0000037)2.41768597
25Optic nerve hypoplasia (HP:0000609)2.40295296
26Cystic liver disease (HP:0006706)2.34489251
27Type II lissencephaly (HP:0007260)2.33882617
28Decreased central vision (HP:0007663)2.31990922
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.31972003
30Large for gestational age (HP:0001520)2.30722655
31Gaze-evoked nystagmus (HP:0000640)2.30621463
32Short 1st metacarpal (HP:0010034)2.30433824
33Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.30433824
34Nephrogenic diabetes insipidus (HP:0009806)2.30350817
35Broad-based gait (HP:0002136)2.29473861
36Hypothermia (HP:0002045)2.28471444
37Absent speech (HP:0001344)2.27547894
38Progressive cerebellar ataxia (HP:0002073)2.26028472
39Hyperglycinemia (HP:0002154)2.24249039
40Lissencephaly (HP:0001339)2.24238093
41Ketosis (HP:0001946)2.17450817
42Abnormal biliary tract physiology (HP:0012439)2.17345360
43Bile duct proliferation (HP:0001408)2.17345360
44Methylmalonic aciduria (HP:0012120)2.17189765
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.14688131
46Genital tract atresia (HP:0001827)2.10412485
47Sclerocornea (HP:0000647)2.09939567
48Hemiparesis (HP:0001269)2.08374431
49Chorioretinal atrophy (HP:0000533)2.06804403
50Vaginal atresia (HP:0000148)2.05352179
51Intestinal atresia (HP:0011100)2.04702497
52Genetic anticipation (HP:0003743)2.04281473
53Abnormal drinking behavior (HP:0030082)2.02539610
54Polydipsia (HP:0001959)2.02539610
55Congenital sensorineural hearing impairment (HP:0008527)2.02181671
56Tubular atrophy (HP:0000092)2.01811408
57Inability to walk (HP:0002540)2.01240107
58Hypoplasia of the fovea (HP:0007750)1.99711730
59Aplasia/Hypoplasia of the fovea (HP:0008060)1.99711730
60Abnormality of the 1st metacarpal (HP:0010009)1.99425055
61Bony spicule pigmentary retinopathy (HP:0007737)1.98910829
62Progressive inability to walk (HP:0002505)1.97095990
63Limb dystonia (HP:0002451)1.97085467
64Abnormality of the renal collecting system (HP:0004742)1.95790756
65Pachygyria (HP:0001302)1.95616568
66Acute necrotizing encephalopathy (HP:0006965)1.94932852
67Anencephaly (HP:0002323)1.94018059
68Renal cortical cysts (HP:0000803)1.93819295
69Drooling (HP:0002307)1.93213885
703-Methylglutaconic aciduria (HP:0003535)1.92114049
71Focal seizures (HP:0007359)1.92048195
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.87605093
73Hypsarrhythmia (HP:0002521)1.86673629
74Agitation (HP:0000713)1.85828082
75Polyphagia (HP:0002591)1.84857553
76Stenosis of the external auditory canal (HP:0000402)1.84855618
77Progressive macrocephaly (HP:0004481)1.84776278
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.84116295
79Absent/shortened dynein arms (HP:0200106)1.84116295
80Ketoacidosis (HP:0001993)1.83663318
81Congenital hepatic fibrosis (HP:0002612)1.83602856
82Epileptiform EEG discharges (HP:0011182)1.82810645
83Mitochondrial inheritance (HP:0001427)1.82099598
84Increased CSF lactate (HP:0002490)1.81799681
85Colon cancer (HP:0003003)1.79630629
86EEG with generalized epileptiform discharges (HP:0011198)1.78987995
87Retinal dysplasia (HP:0007973)1.78928717
88Abnormality of the fovea (HP:0000493)1.78916534
89Acute encephalopathy (HP:0006846)1.78646506
90Febrile seizures (HP:0002373)1.78462659
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76522616
92Postaxial foot polydactyly (HP:0001830)1.76280961
93Astigmatism (HP:0000483)1.76022695
94Specific learning disability (HP:0001328)1.75893693
95Postaxial hand polydactyly (HP:0001162)1.75766643
96Narrow forehead (HP:0000341)1.75103201
97Furrowed tongue (HP:0000221)1.74094684
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.74000455
99Excessive salivation (HP:0003781)1.69147662
100Abnormality of vitamin B metabolism (HP:0004340)1.68953380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.31520655
2BCKDK3.30299748
3WNK33.07717151
4MAP4K22.87837313
5ADRBK22.58612407
6PINK12.45307128
7CASK2.43458326
8MAPK132.42242074
9GRK12.32171635
10MAP3K42.28801092
11MARK12.18376028
12NUAK12.15853367
13BMPR1B2.09247591
14BCR1.91301268
15TAOK31.88772661
16MAP2K71.78819596
17TRIM281.64722560
18CSNK1G21.55499710
19PLK21.52925475
20CSNK1G31.51830986
21CSNK1G11.50352742
22ZAK1.50005330
23DYRK21.44999480
24OXSR11.44429942
25EIF2AK31.44223329
26INSRR1.43699229
27ERBB31.40170303
28CSNK1A1L1.39157721
29STK391.21847498
30DAPK21.20552793
31ACVR1B1.18561876
32CDK191.16889898
33PAK31.15140766
34PRKCE1.11401038
35PRKCG1.10683131
36EPHA41.07111729
37WNK41.03202081
38NTRK30.98912580
39STK38L0.96021054
40TIE10.93058314
41NTRK20.89852101
42CAMKK20.88011667
43MINK10.84099668
44ADRBK10.82849101
45MKNK20.81942314
46PLK40.75347145
47CAMK2A0.75328300
48MUSK0.73805621
49FGFR20.72818845
50VRK10.71999294
51TAF10.70419328
52RPS6KA40.69245206
53FLT30.65192820
54PHKG10.60775602
55PHKG20.60775602
56DYRK30.60709474
57SGK20.60035974
58PLK30.59537989
59TXK0.57872647
60SGK4940.57801708
61SGK2230.57801708
62PRKCZ0.57008595
63FER0.56440902
64PRKACA0.55265275
65CSNK1A10.54519812
66MAP2K40.53875456
67SRPK10.53000812
68PKN10.52770254
69TLK10.50888987
70MST40.49034782
71PTK2B0.48516955
72RPS6KA50.47667016
73OBSCN0.47364460
74PAK60.45672072
75PNCK0.45540186
76LIMK10.44822750
77CAMK2B0.44467387
78CAMK40.44004721
79CSNK1D0.43975583
80TNIK0.43316113
81CAMK10.42561682
82CDK50.42409612
83PRKD20.39235368
84DYRK1A0.39177987
85PLK10.38976248
86STK110.38702441
87TGFBR10.37908626
88CAMK2D0.37145989
89PRKAA10.36389950
90PRKCA0.35831645
91PRKG10.33939595
92GRK50.32659829
93PRKCI0.32572235
94GRK70.29842730
95IRAK10.29815809
96MKNK10.29104281
97AURKA0.28992399
98ATM0.27859534
99CSNK1E0.27818738
100MAPKAPK50.26742242

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.94463663
2Phototransduction_Homo sapiens_hsa047442.67009100
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57238062
4Butanoate metabolism_Homo sapiens_hsa006502.47157422
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.31776498
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28363554
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23934148
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01091967
9Protein export_Homo sapiens_hsa030601.96894145
10Propanoate metabolism_Homo sapiens_hsa006401.94997270
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93894377
12Selenocompound metabolism_Homo sapiens_hsa004501.89058556
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86977042
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82974437
15Oxidative phosphorylation_Homo sapiens_hsa001901.73396703
16Basal transcription factors_Homo sapiens_hsa030221.72573398
17Linoleic acid metabolism_Homo sapiens_hsa005911.70767702
18Morphine addiction_Homo sapiens_hsa050321.65491017
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64579049
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64555553
21Tryptophan metabolism_Homo sapiens_hsa003801.64021100
22Fanconi anemia pathway_Homo sapiens_hsa034601.59621978
23GABAergic synapse_Homo sapiens_hsa047271.58229569
24Taste transduction_Homo sapiens_hsa047421.57887821
25Olfactory transduction_Homo sapiens_hsa047401.54185912
26Ether lipid metabolism_Homo sapiens_hsa005651.48419860
27Circadian entrainment_Homo sapiens_hsa047131.44906109
28Insulin secretion_Homo sapiens_hsa049111.41868856
29Parkinsons disease_Homo sapiens_hsa050121.40875677
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38815274
31RNA polymerase_Homo sapiens_hsa030201.37103572
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33813189
33Peroxisome_Homo sapiens_hsa041461.29677949
34Glutamatergic synapse_Homo sapiens_hsa047241.24085341
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21944469
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19756192
37Serotonergic synapse_Homo sapiens_hsa047261.18609366
38Sulfur metabolism_Homo sapiens_hsa009201.16353233
39Steroid biosynthesis_Homo sapiens_hsa001001.12693882
40RNA degradation_Homo sapiens_hsa030181.11918526
41Homologous recombination_Homo sapiens_hsa034401.11074580
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.10945142
43Salivary secretion_Homo sapiens_hsa049701.10657447
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09814123
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09423805
46Nitrogen metabolism_Homo sapiens_hsa009101.08116804
47Chemical carcinogenesis_Homo sapiens_hsa052041.03720493
48Regulation of autophagy_Homo sapiens_hsa041401.03191476
49Cardiac muscle contraction_Homo sapiens_hsa042600.99423533
50ABC transporters_Homo sapiens_hsa020100.98019621
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.97413687
52Dopaminergic synapse_Homo sapiens_hsa047280.96622241
53Retinol metabolism_Homo sapiens_hsa008300.95624689
54Caffeine metabolism_Homo sapiens_hsa002320.95351445
55Huntingtons disease_Homo sapiens_hsa050160.93882156
56Collecting duct acid secretion_Homo sapiens_hsa049660.93664329
57Fatty acid elongation_Homo sapiens_hsa000620.87207410
58beta-Alanine metabolism_Homo sapiens_hsa004100.86577408
59Alzheimers disease_Homo sapiens_hsa050100.84095616
60Non-homologous end-joining_Homo sapiens_hsa034500.83435149
61Calcium signaling pathway_Homo sapiens_hsa040200.83100512
62Dorso-ventral axis formation_Homo sapiens_hsa043200.81698038
63Amphetamine addiction_Homo sapiens_hsa050310.81098323
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79756824
65Sulfur relay system_Homo sapiens_hsa041220.78755424
66Synaptic vesicle cycle_Homo sapiens_hsa047210.77818108
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77795500
68Cocaine addiction_Homo sapiens_hsa050300.77263204
69Long-term depression_Homo sapiens_hsa047300.76612228
70Fatty acid degradation_Homo sapiens_hsa000710.74839055
71Circadian rhythm_Homo sapiens_hsa047100.70457697
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70193990
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68046523
74Renin secretion_Homo sapiens_hsa049240.66441681
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62876805
76Glycerolipid metabolism_Homo sapiens_hsa005610.62247086
77Fatty acid metabolism_Homo sapiens_hsa012120.61765750
78Histidine metabolism_Homo sapiens_hsa003400.61337766
79Arachidonic acid metabolism_Homo sapiens_hsa005900.60399865
80Ovarian steroidogenesis_Homo sapiens_hsa049130.60353874
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60066164
82Metabolic pathways_Homo sapiens_hsa011000.58699933
83cAMP signaling pathway_Homo sapiens_hsa040240.57711152
84Purine metabolism_Homo sapiens_hsa002300.57029709
85Fat digestion and absorption_Homo sapiens_hsa049750.52073234
86Cholinergic synapse_Homo sapiens_hsa047250.50333262
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50042323
88Hedgehog signaling pathway_Homo sapiens_hsa043400.48882407
89Oocyte meiosis_Homo sapiens_hsa041140.48224472
90Base excision repair_Homo sapiens_hsa034100.47620207
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46115816
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43808047
93Axon guidance_Homo sapiens_hsa043600.41750585
94Starch and sucrose metabolism_Homo sapiens_hsa005000.41112092
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.40819585
96Folate biosynthesis_Homo sapiens_hsa007900.39813204
97Arginine and proline metabolism_Homo sapiens_hsa003300.39686510
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39215281
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37685135
100RNA transport_Homo sapiens_hsa030130.36454922

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