ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.95339597
2	piRNA metabolic process (GO:0034587)	4.10562547
3	protein polyglutamylation (GO:0018095)	4.03377613
4	pyrimidine nucleobase catabolic process (GO:0006208)	3.86167340
5	gamma-aminobutyric acid transport (GO:0015812)	3.77414487
6	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.60698851
7	water-soluble vitamin biosynthetic process (GO:0042364)	3.41849159
8	protein K11-linked deubiquitination (GO:0035871)	3.28926119
9	neural tube formation (GO:0001841)	3.26373456
10	nucleobase catabolic process (GO:0046113)	3.23695738
11	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.22801114
12	DNA methylation involved in gamete generation (GO:0043046)	3.21614614
13	cornea development in camera-type eye (GO:0061303)	3.05944868
14	presynaptic membrane assembly (GO:0097105)	3.04984653
15	positive regulation of amino acid transport (GO:0051957)	3.01313249
16	startle response (GO:0001964)	2.99369947
17	response to pheromone (GO:0019236)	2.99300372
18	NADH dehydrogenase complex assembly (GO:0010257)	2.99022722
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99022722
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99022722
21	regulation of action potential (GO:0098900)	2.98272910
22	negative regulation of telomere maintenance (GO:0032205)	2.98236298
23	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.98068207
24	sulfation (GO:0051923)	2.97798478
25	serotonin receptor signaling pathway (GO:0007210)	2.97668575
26	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.96723880
27	indolalkylamine metabolic process (GO:0006586)	2.95601511
28	axoneme assembly (GO:0035082)	2.95120182
29	retinal cone cell development (GO:0046549)	2.93129712
30	somite development (GO:0061053)	2.90662212
31	platelet dense granule organization (GO:0060155)	2.90420441
32	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.89959418
33	parturition (GO:0007567)	2.89908851
34	seminiferous tubule development (GO:0072520)	2.89525654
35	detection of light stimulus involved in visual perception (GO:0050908)	2.89022633
36	detection of light stimulus involved in sensory perception (GO:0050962)	2.89022633
37	protein complex biogenesis (GO:0070271)	2.87805608
38	regulation of meiosis I (GO:0060631)	2.87799139
39	L-fucose catabolic process (GO:0042355)	2.87518031
40	fucose catabolic process (GO:0019317)	2.87518031
41	L-fucose metabolic process (GO:0042354)	2.87518031
42	negative regulation of mast cell activation (GO:0033004)	2.87271358
43	tryptophan catabolic process (GO:0006569)	2.85781323
44	indole-containing compound catabolic process (GO:0042436)	2.85781323
45	indolalkylamine catabolic process (GO:0046218)	2.85781323
46	epithelial cilium movement (GO:0003351)	2.85125078
47	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.84426451
48	behavioral response to ethanol (GO:0048149)	2.83390884
49	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.82130538
50	cell proliferation in forebrain (GO:0021846)	2.81484114
51	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.81000896
52	cellular ketone body metabolic process (GO:0046950)	2.78577634
53	head development (GO:0060322)	2.73535150
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.72774331
55	transmission of nerve impulse (GO:0019226)	2.69098838
56	DNA deamination (GO:0045006)	2.68654595
57	neuronal action potential (GO:0019228)	2.68132284
58	nonmotile primary cilium assembly (GO:0035058)	2.66785512
59	reflex (GO:0060004)	2.65104275
60	presynaptic membrane organization (GO:0097090)	2.65071798
61	positive regulation of meiosis (GO:0045836)	2.64565794
62	kynurenine metabolic process (GO:0070189)	2.61811220
63	indole-containing compound metabolic process (GO:0042430)	2.61164034
64	serotonin metabolic process (GO:0042428)	2.61132292
65	mitochondrial respiratory chain complex assembly (GO:0033108)	2.61100408
66	tryptophan metabolic process (GO:0006568)	2.60926004
67	resolution of meiotic recombination intermediates (GO:0000712)	2.60138915
68	cellular response to ATP (GO:0071318)	2.57916691
69	photoreceptor cell development (GO:0042461)	2.56272150
70	positive regulation of catecholamine secretion (GO:0033605)	2.55624028
71	cullin deneddylation (GO:0010388)	2.55390022
72	photoreceptor cell maintenance (GO:0045494)	2.54886205
73	primary amino compound metabolic process (GO:1901160)	2.53727678
74	neuron cell-cell adhesion (GO:0007158)	2.51739316
75	cilium morphogenesis (GO:0060271)	2.50687843
76	regulation of hexokinase activity (GO:1903299)	2.50287096
77	regulation of glucokinase activity (GO:0033131)	2.50287096
78	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.49632181
79	DNA double-strand break processing (GO:0000729)	2.49262855
80	protein-cofactor linkage (GO:0018065)	2.48234506
81	embryonic epithelial tube formation (GO:0001838)	2.47233347
82	ketone body metabolic process (GO:1902224)	2.46520215
83	regulation of collateral sprouting (GO:0048670)	2.45544990
84	synaptic transmission, glutamatergic (GO:0035249)	2.44893715
85	regulation of male gonad development (GO:2000018)	2.44733866
86	otic vesicle formation (GO:0030916)	2.44001792
87	negative regulation of appetite (GO:0032099)	2.43830564
88	negative regulation of response to food (GO:0032096)	2.43830564
89	positive regulation of meiotic cell cycle (GO:0051446)	2.43662512
90	positive regulation of mitochondrial fission (GO:0090141)	2.43055030
91	adaptation of signaling pathway (GO:0023058)	2.41795385
92	cilium organization (GO:0044782)	2.41113059
93	intraciliary transport (GO:0042073)	2.41084855
94	male meiosis I (GO:0007141)	2.40336044
95	L-methionine salvage (GO:0071267)	2.38594271
96	L-methionine biosynthetic process (GO:0071265)	2.38594271
97	amino acid salvage (GO:0043102)	2.38594271
98	synapsis (GO:0007129)	2.36558793
99	protein deneddylation (GO:0000338)	2.36531505
100	aggressive behavior (GO:0002118)	2.35909410

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.59099739
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.58274075
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.47726061
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.14401751
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.85585964
6	VDR_22108803_ChIP-Seq_LS180_Human	2.66207003
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.60007495
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48201132
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31563078
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.29279991
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.25501772
12	FUS_26573619_Chip-Seq_HEK293_Human	2.23387426
13	EWS_26573619_Chip-Seq_HEK293_Human	2.21246286
14	P300_19829295_ChIP-Seq_ESCs_Human	2.08941263
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01833368
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.00749057
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96205064
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.89216487
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87157592
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.83675126
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79298080
22	RNF2_27304074_Chip-Seq_NSC_Mouse	1.73161412
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.70485579
24	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.69288245
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69116291
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68851906
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.67959779
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.67939341
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.63332983
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61281174
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60828605
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.57219384
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.56710150
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.56187915
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56012879
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.56012879
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55676210
38	STAT3_23295773_ChIP-Seq_U87_Human	1.55494613
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54797502
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49828692
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49607042
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48962062
43	AR_25329375_ChIP-Seq_VCAP_Human	1.48330552
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.48247821
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47454520
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47410624
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46563024
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45438297
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43432264
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.41649026
51	TCF4_23295773_ChIP-Seq_U87_Human	1.40584355
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40221277
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.36680801
54	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.33665707
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32598474
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28641594
57	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.27588176
58	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.26515708
59	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25269704
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24946562
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.22506581
62	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.22462349
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22185054
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21480019
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21373548
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18837238
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18837238
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17307465
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.17173770
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16466765
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16466765
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15859216
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15391354
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14533988
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14476864
76	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.14236230
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13579437
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12992765
79	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12281157
80	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11249914
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10236586
82	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.08949582
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08744920
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08309710
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08172126
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05792220
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05792220
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04356090
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03848033
90	AR_21572438_ChIP-Seq_LNCaP_Human	1.03628646
91	NCOR_22424771_ChIP-Seq_293T_Human	1.02052859
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00137492
93	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99822084
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99730487
95	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.99329152
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98728075
97	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98240138
98	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96578655
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96185762
100	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.95762933

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.15608182
2	MP0002102_abnormal_ear_morphology	2.69755369
3	MP0006292_abnormal_olfactory_placode	2.53115142
4	MP0001968_abnormal_touch/_nociception	2.46521361
5	MP0003787_abnormal_imprinting	2.43507051
6	MP0002736_abnormal_nociception_after	2.20948383
7	MP0005646_abnormal_pituitary_gland	2.18955782
8	MP0005551_abnormal_eye_electrophysiolog	2.17698197
9	MP0003880_abnormal_central_pattern	2.10936758
10	MP0009745_abnormal_behavioral_response	2.06452102
11	MP0006276_abnormal_autonomic_nervous	2.04753598
12	MP0009046_muscle_twitch	2.01363267
13	MP0002272_abnormal_nervous_system	1.98622863
14	MP0001984_abnormal_olfaction	1.93902030
15	MP0002160_abnormal_reproductive_system	1.89323483
16	MP0002735_abnormal_chemical_nociception	1.84656860
17	MP0006072_abnormal_retinal_apoptosis	1.84127941
18	MP0002837_dystrophic_cardiac_calcinosis	1.80495202
19	MP0001529_abnormal_vocalization	1.79412923
20	MP0003195_calcinosis	1.76862764
21	MP0001486_abnormal_startle_reflex	1.75971212
22	MP0004885_abnormal_endolymph	1.75245063
23	MP0000631_abnormal_neuroendocrine_gland	1.70682411
24	MP0005389_reproductive_system_phenotype	1.68112931
25	MP0000049_abnormal_middle_ear	1.66622705
26	MP0005253_abnormal_eye_physiology	1.65518627
27	MP0004142_abnormal_muscle_tone	1.62982912
28	MP0003121_genomic_imprinting	1.62157894
29	MP0001986_abnormal_taste_sensitivity	1.60008669
30	MP0003122_maternal_imprinting	1.57343934
31	MP0002234_abnormal_pharynx_morphology	1.52425883
32	MP0005645_abnormal_hypothalamus_physiol	1.52311254
33	MP0003635_abnormal_synaptic_transmissio	1.51670668
34	MP0002572_abnormal_emotion/affect_behav	1.49358568
35	MP0002064_seizures	1.48223557
36	MP0001485_abnormal_pinna_reflex	1.48186534
37	MP0003646_muscle_fatigue	1.47569347
38	MP0004270_analgesia	1.45201048
39	MP0004133_heterotaxia	1.44330491
40	MP0002638_abnormal_pupillary_reflex	1.43999618
41	MP0000778_abnormal_nervous_system	1.41328556
42	MP0002063_abnormal_learning/memory/cond	1.40206128
43	MP0002734_abnormal_mechanical_nocicepti	1.38793672
44	MP0002557_abnormal_social/conspecific_i	1.35339335
45	MP0004859_abnormal_synaptic_plasticity	1.33985813
46	MP0004145_abnormal_muscle_electrophysio	1.33070783
47	MP0005084_abnormal_gallbladder_morpholo	1.32169064
48	MP0001501_abnormal_sleep_pattern	1.31595589
49	MP0008995_early_reproductive_senescence	1.31036330
50	MP0008872_abnormal_physiological_respon	1.29887176
51	MP0001970_abnormal_pain_threshold	1.29783688
52	MP0001919_abnormal_reproductive_system	1.28217928
53	MP0002138_abnormal_hepatobiliary_system	1.24384800
54	MP0002733_abnormal_thermal_nociception	1.24055102
55	MP0003718_maternal_effect	1.23927649
56	MP0003011_delayed_dark_adaptation	1.23143208
57	MP0003119_abnormal_digestive_system	1.22742617
58	MP0004215_abnormal_myocardial_fiber	1.21130529
59	MP0008789_abnormal_olfactory_epithelium	1.20056653
60	MP0002928_abnormal_bile_duct	1.17906563
61	MP0002876_abnormal_thyroid_physiology	1.14397483
62	MP0002653_abnormal_ependyma_morphology	1.14299832
63	MP0004147_increased_porphyrin_level	1.13210008
64	MP0002822_catalepsy	1.12090768
65	MP0010386_abnormal_urinary_bladder	1.11906884
66	MP0002751_abnormal_autonomic_nervous	1.11400351
67	MP0005499_abnormal_olfactory_system	1.09528017
68	MP0005394_taste/olfaction_phenotype	1.09528017
69	MP0005386_behavior/neurological_phenoty	1.08407455
70	MP0004924_abnormal_behavior	1.08407455
71	MP0005410_abnormal_fertilization	1.06925912
72	MP0002067_abnormal_sensory_capabilities	1.05326849
73	MP0003890_abnormal_embryonic-extraembry	1.04231430
74	MP0000372_irregular_coat_pigmentation	1.03344428
75	MP0002184_abnormal_innervation	1.02500839
76	MP0000427_abnormal_hair_cycle	1.01659846
77	MP0005195_abnormal_posterior_eye	1.00799236
78	MP0002909_abnormal_adrenal_gland	0.99877217
79	MP0003136_yellow_coat_color	0.99472099
80	MP0001905_abnormal_dopamine_level	0.98337629
81	MP0008058_abnormal_DNA_repair	0.97906153
82	MP0003937_abnormal_limbs/digits/tail_de	0.97582842
83	MP0002752_abnormal_somatic_nervous	0.96539738
84	MP0003698_abnormal_male_reproductive	0.96302751
85	MP0008875_abnormal_xenobiotic_pharmacok	0.96248681
86	MP0002163_abnormal_gland_morphology	0.96068919
87	MP0003567_abnormal_fetal_cardiomyocyte	0.94944141
88	MP0002938_white_spotting	0.93951756
89	MP0001963_abnormal_hearing_physiology	0.93943393
90	MP0002210_abnormal_sex_determination	0.93871506
91	MP0004043_abnormal_pH_regulation	0.93205548
92	MP0005423_abnormal_somatic_nervous	0.92796298
93	MP0001929_abnormal_gametogenesis	0.91393913
94	MP0001188_hyperpigmentation	0.90856920
95	MP0002229_neurodegeneration	0.90078114
96	MP0005379_endocrine/exocrine_gland_phen	0.89078193
97	MP0002882_abnormal_neuron_morphology	0.88892936
98	MP0008961_abnormal_basal_metabolism	0.86864055
99	MP0000653_abnormal_sex_gland	0.86054103
100	MP0003938_abnormal_ear_development	0.85907549

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.31139719
2	Pancreatic cysts (HP:0001737)	3.90199979
3	Pancreatic fibrosis (HP:0100732)	3.62755884
4	Abnormality of midbrain morphology (HP:0002418)	3.47745878
5	Molar tooth sign on MRI (HP:0002419)	3.47745878
6	Nephronophthisis (HP:0000090)	3.39615110
7	Congenital stationary night blindness (HP:0007642)	3.30922340
8	Hyperventilation (HP:0002883)	3.19992387
9	Pendular nystagmus (HP:0012043)	3.17267973
10	Medial flaring of the eyebrow (HP:0010747)	3.10397892
11	Abolished electroretinogram (ERG) (HP:0000550)	2.98835794
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.97771954
13	Methylmalonic acidemia (HP:0002912)	2.94937591
14	Abnormal rod and cone electroretinograms (HP:0008323)	2.90966448
15	Attenuation of retinal blood vessels (HP:0007843)	2.82327776
16	Abnormality of the renal medulla (HP:0100957)	2.82015964
17	Gait imbalance (HP:0002141)	2.59830443
18	Abnormality of the labia minora (HP:0012880)	2.54990808
19	Increased corneal curvature (HP:0100692)	2.48041468
20	Keratoconus (HP:0000563)	2.48041468
21	Chronic hepatic failure (HP:0100626)	2.47418535
22	Abnormality of the renal cortex (HP:0011035)	2.47215273
23	Congenital primary aphakia (HP:0007707)	2.46862709
24	Male pseudohermaphroditism (HP:0000037)	2.41768597
25	Optic nerve hypoplasia (HP:0000609)	2.40295296
26	Cystic liver disease (HP:0006706)	2.34489251
27	Type II lissencephaly (HP:0007260)	2.33882617
28	Decreased central vision (HP:0007663)	2.31990922
29	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31972003
30	Large for gestational age (HP:0001520)	2.30722655
31	Gaze-evoked nystagmus (HP:0000640)	2.30621463
32	Short 1st metacarpal (HP:0010034)	2.30433824
33	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.30433824
34	Nephrogenic diabetes insipidus (HP:0009806)	2.30350817
35	Broad-based gait (HP:0002136)	2.29473861
36	Hypothermia (HP:0002045)	2.28471444
37	Absent speech (HP:0001344)	2.27547894
38	Progressive cerebellar ataxia (HP:0002073)	2.26028472
39	Hyperglycinemia (HP:0002154)	2.24249039
40	Lissencephaly (HP:0001339)	2.24238093
41	Ketosis (HP:0001946)	2.17450817
42	Abnormal biliary tract physiology (HP:0012439)	2.17345360
43	Bile duct proliferation (HP:0001408)	2.17345360
44	Methylmalonic aciduria (HP:0012120)	2.17189765
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14688131
46	Genital tract atresia (HP:0001827)	2.10412485
47	Sclerocornea (HP:0000647)	2.09939567
48	Hemiparesis (HP:0001269)	2.08374431
49	Chorioretinal atrophy (HP:0000533)	2.06804403
50	Vaginal atresia (HP:0000148)	2.05352179
51	Intestinal atresia (HP:0011100)	2.04702497
52	Genetic anticipation (HP:0003743)	2.04281473
53	Abnormal drinking behavior (HP:0030082)	2.02539610
54	Polydipsia (HP:0001959)	2.02539610
55	Congenital sensorineural hearing impairment (HP:0008527)	2.02181671
56	Tubular atrophy (HP:0000092)	2.01811408
57	Inability to walk (HP:0002540)	2.01240107
58	Hypoplasia of the fovea (HP:0007750)	1.99711730
59	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.99711730
60	Abnormality of the 1st metacarpal (HP:0010009)	1.99425055
61	Bony spicule pigmentary retinopathy (HP:0007737)	1.98910829
62	Progressive inability to walk (HP:0002505)	1.97095990
63	Limb dystonia (HP:0002451)	1.97085467
64	Abnormality of the renal collecting system (HP:0004742)	1.95790756
65	Pachygyria (HP:0001302)	1.95616568
66	Acute necrotizing encephalopathy (HP:0006965)	1.94932852
67	Anencephaly (HP:0002323)	1.94018059
68	Renal cortical cysts (HP:0000803)	1.93819295
69	Drooling (HP:0002307)	1.93213885
70	3-Methylglutaconic aciduria (HP:0003535)	1.92114049
71	Focal seizures (HP:0007359)	1.92048195
72	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87605093
73	Hypsarrhythmia (HP:0002521)	1.86673629
74	Agitation (HP:0000713)	1.85828082
75	Polyphagia (HP:0002591)	1.84857553
76	Stenosis of the external auditory canal (HP:0000402)	1.84855618
77	Progressive macrocephaly (HP:0004481)	1.84776278
78	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.84116295
79	Absent/shortened dynein arms (HP:0200106)	1.84116295
80	Ketoacidosis (HP:0001993)	1.83663318
81	Congenital hepatic fibrosis (HP:0002612)	1.83602856
82	Epileptiform EEG discharges (HP:0011182)	1.82810645
83	Mitochondrial inheritance (HP:0001427)	1.82099598
84	Increased CSF lactate (HP:0002490)	1.81799681
85	Colon cancer (HP:0003003)	1.79630629
86	EEG with generalized epileptiform discharges (HP:0011198)	1.78987995
87	Retinal dysplasia (HP:0007973)	1.78928717
88	Abnormality of the fovea (HP:0000493)	1.78916534
89	Acute encephalopathy (HP:0006846)	1.78646506
90	Febrile seizures (HP:0002373)	1.78462659
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.76522616
92	Postaxial foot polydactyly (HP:0001830)	1.76280961
93	Astigmatism (HP:0000483)	1.76022695
94	Specific learning disability (HP:0001328)	1.75893693
95	Postaxial hand polydactyly (HP:0001162)	1.75766643
96	Narrow forehead (HP:0000341)	1.75103201
97	Furrowed tongue (HP:0000221)	1.74094684
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74000455
99	Excessive salivation (HP:0003781)	1.69147662
100	Abnormality of vitamin B metabolism (HP:0004340)	1.68953380

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.31520655
2	BCKDK	3.30299748
3	WNK3	3.07717151
4	MAP4K2	2.87837313
5	ADRBK2	2.58612407
6	PINK1	2.45307128
7	CASK	2.43458326
8	MAPK13	2.42242074
9	GRK1	2.32171635
10	MAP3K4	2.28801092
11	MARK1	2.18376028
12	NUAK1	2.15853367
13	BMPR1B	2.09247591
14	BCR	1.91301268
15	TAOK3	1.88772661
16	MAP2K7	1.78819596
17	TRIM28	1.64722560
18	CSNK1G2	1.55499710
19	PLK2	1.52925475
20	CSNK1G3	1.51830986
21	CSNK1G1	1.50352742
22	ZAK	1.50005330
23	DYRK2	1.44999480
24	OXSR1	1.44429942
25	EIF2AK3	1.44223329
26	INSRR	1.43699229
27	ERBB3	1.40170303
28	CSNK1A1L	1.39157721
29	STK39	1.21847498
30	DAPK2	1.20552793
31	ACVR1B	1.18561876
32	CDK19	1.16889898
33	PAK3	1.15140766
34	PRKCE	1.11401038
35	PRKCG	1.10683131
36	EPHA4	1.07111729
37	WNK4	1.03202081
38	NTRK3	0.98912580
39	STK38L	0.96021054
40	TIE1	0.93058314
41	NTRK2	0.89852101
42	CAMKK2	0.88011667
43	MINK1	0.84099668
44	ADRBK1	0.82849101
45	MKNK2	0.81942314
46	PLK4	0.75347145
47	CAMK2A	0.75328300
48	MUSK	0.73805621
49	FGFR2	0.72818845
50	VRK1	0.71999294
51	TAF1	0.70419328
52	RPS6KA4	0.69245206
53	FLT3	0.65192820
54	PHKG1	0.60775602
55	PHKG2	0.60775602
56	DYRK3	0.60709474
57	SGK2	0.60035974
58	PLK3	0.59537989
59	TXK	0.57872647
60	SGK494	0.57801708
61	SGK223	0.57801708
62	PRKCZ	0.57008595
63	FER	0.56440902
64	PRKACA	0.55265275
65	CSNK1A1	0.54519812
66	MAP2K4	0.53875456
67	SRPK1	0.53000812
68	PKN1	0.52770254
69	TLK1	0.50888987
70	MST4	0.49034782
71	PTK2B	0.48516955
72	RPS6KA5	0.47667016
73	OBSCN	0.47364460
74	PAK6	0.45672072
75	PNCK	0.45540186
76	LIMK1	0.44822750
77	CAMK2B	0.44467387
78	CAMK4	0.44004721
79	CSNK1D	0.43975583
80	TNIK	0.43316113
81	CAMK1	0.42561682
82	CDK5	0.42409612
83	PRKD2	0.39235368
84	DYRK1A	0.39177987
85	PLK1	0.38976248
86	STK11	0.38702441
87	TGFBR1	0.37908626
88	CAMK2D	0.37145989
89	PRKAA1	0.36389950
90	PRKCA	0.35831645
91	PRKG1	0.33939595
92	GRK5	0.32659829
93	PRKCI	0.32572235
94	GRK7	0.29842730
95	IRAK1	0.29815809
96	MKNK1	0.29104281
97	AURKA	0.28992399
98	ATM	0.27859534
99	CSNK1E	0.27818738
100	MAPKAPK5	0.26742242

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.94463663
2	Phototransduction_Homo sapiens_hsa04744	2.67009100
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.57238062
4	Butanoate metabolism_Homo sapiens_hsa00650	2.47157422
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.31776498
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.28363554
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23934148
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01091967
9	Protein export_Homo sapiens_hsa03060	1.96894145
10	Propanoate metabolism_Homo sapiens_hsa00640	1.94997270
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.93894377
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.89058556
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.86977042
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82974437
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.73396703
16	Basal transcription factors_Homo sapiens_hsa03022	1.72573398
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70767702
18	Morphine addiction_Homo sapiens_hsa05032	1.65491017
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.64579049
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.64555553
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.64021100
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59621978
23	GABAergic synapse_Homo sapiens_hsa04727	1.58229569
24	Taste transduction_Homo sapiens_hsa04742	1.57887821
25	Olfactory transduction_Homo sapiens_hsa04740	1.54185912
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.48419860
27	Circadian entrainment_Homo sapiens_hsa04713	1.44906109
28	Insulin secretion_Homo sapiens_hsa04911	1.41868856
29	Parkinsons disease_Homo sapiens_hsa05012	1.40875677
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.38815274
31	RNA polymerase_Homo sapiens_hsa03020	1.37103572
32	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.33813189
33	Peroxisome_Homo sapiens_hsa04146	1.29677949
34	Glutamatergic synapse_Homo sapiens_hsa04724	1.24085341
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21944469
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.19756192
37	Serotonergic synapse_Homo sapiens_hsa04726	1.18609366
38	Sulfur metabolism_Homo sapiens_hsa00920	1.16353233
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.12693882
40	RNA degradation_Homo sapiens_hsa03018	1.11918526
41	Homologous recombination_Homo sapiens_hsa03440	1.11074580
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10945142
43	Salivary secretion_Homo sapiens_hsa04970	1.10657447
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09814123
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09423805
46	Nitrogen metabolism_Homo sapiens_hsa00910	1.08116804
47	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03720493
48	Regulation of autophagy_Homo sapiens_hsa04140	1.03191476
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99423533
50	ABC transporters_Homo sapiens_hsa02010	0.98019621
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97413687
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.96622241
53	Retinol metabolism_Homo sapiens_hsa00830	0.95624689
54	Caffeine metabolism_Homo sapiens_hsa00232	0.95351445
55	Huntingtons disease_Homo sapiens_hsa05016	0.93882156
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93664329
57	Fatty acid elongation_Homo sapiens_hsa00062	0.87207410
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86577408
59	Alzheimers disease_Homo sapiens_hsa05010	0.84095616
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.83435149
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.83100512
62	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81698038
63	Amphetamine addiction_Homo sapiens_hsa05031	0.81098323
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79756824
65	Sulfur relay system_Homo sapiens_hsa04122	0.78755424
66	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.77818108
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77795500
68	Cocaine addiction_Homo sapiens_hsa05030	0.77263204
69	Long-term depression_Homo sapiens_hsa04730	0.76612228
70	Fatty acid degradation_Homo sapiens_hsa00071	0.74839055
71	Circadian rhythm_Homo sapiens_hsa04710	0.70457697
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70193990
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68046523
74	Renin secretion_Homo sapiens_hsa04924	0.66441681
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.62876805
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62247086
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.61765750
78	Histidine metabolism_Homo sapiens_hsa00340	0.61337766
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60399865
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60353874
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60066164
82	Metabolic pathways_Homo sapiens_hsa01100	0.58699933
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.57711152
84	Purine metabolism_Homo sapiens_hsa00230	0.57029709
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.52073234
86	Cholinergic synapse_Homo sapiens_hsa04725	0.50333262
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50042323
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48882407
89	Oocyte meiosis_Homo sapiens_hsa04114	0.48224472
90	Base excision repair_Homo sapiens_hsa03410	0.47620207
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46115816
92	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.43808047
93	Axon guidance_Homo sapiens_hsa04360	0.41750585
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.41112092
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40819585
96	Folate biosynthesis_Homo sapiens_hsa00790	0.39813204
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39686510
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39215281
99	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.37685135
100	RNA transport_Homo sapiens_hsa03013	0.36454922

ZNF285

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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