ZNF285B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral mRNA export from host cell nucleus (GO:0046784)7.69734730
2response to pheromone (GO:0019236)6.69791586
3postsynaptic membrane organization (GO:0001941)5.12837702
4microtubule depolymerization (GO:0007019)5.08237234
5DNA ligation (GO:0006266)4.96889791
6positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.91526264
7muscle organ morphogenesis (GO:0048644)4.61022031
8cysteine metabolic process (GO:0006534)4.47982353
9CENP-A containing nucleosome assembly (GO:0034080)4.42265803
10mitotic metaphase plate congression (GO:0007080)4.40804881
11purine-containing compound salvage (GO:0043101)4.34707779
12metaphase plate congression (GO:0051310)4.33232047
13protein prenylation (GO:0018342)4.18824408
14prenylation (GO:0097354)4.18824408
15chromatin remodeling at centromere (GO:0031055)4.06422676
16blood vessel maturation (GO:0001955)4.05674024
17sequestering of actin monomers (GO:0042989)3.98295752
18negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.95810457
19mesenchymal cell differentiation involved in renal system development (GO:2001012)3.82563610
20mesenchymal cell differentiation involved in kidney development (GO:0072161)3.82563610
21positive regulation of RNA splicing (GO:0033120)3.82512737
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.81964931
23NADH dehydrogenase complex assembly (GO:0010257)3.81964931
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81964931
25lateral sprouting from an epithelium (GO:0060601)3.70991164
26histone exchange (GO:0043486)3.69663561
27protein localization to chromosome, centromeric region (GO:0071459)3.64524885
28establishment of chromosome localization (GO:0051303)3.45522208
29presynaptic membrane assembly (GO:0097105)3.37987755
30DNA topological change (GO:0006265)3.34436038
31sister chromatid segregation (GO:0000819)3.32715748
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26649224
33protein heterotetramerization (GO:0051290)3.24410492
34negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.23326076
35poly(A)+ mRNA export from nucleus (GO:0016973)3.22656670
36resolution of meiotic recombination intermediates (GO:0000712)3.20640597
37response to folic acid (GO:0051593)3.20231887
38regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.19159061
39positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.19159061
40positive regulation of cardiac muscle cell differentiation (GO:2000727)3.15188756
41cellular response to ATP (GO:0071318)3.14252429
42regulation of triglyceride catabolic process (GO:0010896)3.11251164
43post-anal tail morphogenesis (GO:0036342)3.11101334
44protein localization to chromosome (GO:0034502)3.10332433
45histone H2A acetylation (GO:0043968)3.10112215
46regulation of retinoic acid receptor signaling pathway (GO:0048385)3.08423576
47V(D)J recombination (GO:0033151)3.04002070
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02994718
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02994718
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.02994718
51regulation of sister chromatid cohesion (GO:0007063)3.02186587
52protein K6-linked ubiquitination (GO:0085020)2.97717241
53regulation of spindle organization (GO:0090224)2.97112057
54otic vesicle formation (GO:0030916)2.96626508
55sulfation (GO:0051923)2.95509443
56high-density lipoprotein particle remodeling (GO:0034375)2.94650307
57replication fork processing (GO:0031297)2.92625157
58protein complex biogenesis (GO:0070271)2.88278381
59presynaptic membrane organization (GO:0097090)2.87790710
60membrane protein ectodomain proteolysis (GO:0006509)2.86876447
61phospholipid efflux (GO:0033700)2.81959419
62mitotic sister chromatid segregation (GO:0000070)2.81040008
63piRNA metabolic process (GO:0034587)2.80944740
64leukotriene biosynthetic process (GO:0019370)2.79908414
65positive regulation of catecholamine secretion (GO:0033605)2.78772694
66microtubule polymerization or depolymerization (GO:0031109)2.77032467
67peristalsis (GO:0030432)2.73146924
68DNA replication-independent nucleosome assembly (GO:0006336)2.71290219
69DNA replication-independent nucleosome organization (GO:0034724)2.71290219
70spermatid nucleus differentiation (GO:0007289)2.70764766
71purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.69553532
72ventricular system development (GO:0021591)2.68877535
73positive regulation of mRNA processing (GO:0050685)2.65829773
74nucleoside salvage (GO:0043174)2.65232374
75neuron fate determination (GO:0048664)2.64191879
76meiotic chromosome segregation (GO:0045132)2.63444655
77chaperone-mediated protein transport (GO:0072321)2.61073763
78mitochondrial respiratory chain complex assembly (GO:0033108)2.60961006
79purine nucleotide salvage (GO:0032261)2.59331802
80DNA integration (GO:0015074)2.59192402
81centriole replication (GO:0007099)2.59072000
82regulation of somitogenesis (GO:0014807)2.58251308
83kinetochore organization (GO:0051383)2.57792896
84telomere maintenance via semi-conservative replication (GO:0032201)2.57751993
85mitochondrion degradation (GO:0000422)2.56885973
86response to oxygen radical (GO:0000305)2.55871164
87mitotic sister chromatid cohesion (GO:0007064)2.55780465
88regulation of heterotypic cell-cell adhesion (GO:0034114)2.55459387
89reverse cholesterol transport (GO:0043691)2.55136709
90apical protein localization (GO:0045176)2.55124110
91behavioral response to ethanol (GO:0048149)2.54715169
92DNA strand renaturation (GO:0000733)2.54401689
93histone-serine phosphorylation (GO:0035404)2.51882477
94regulation of mitotic spindle organization (GO:0060236)2.51657162
95response to hydroperoxide (GO:0033194)2.50375303
96regulation of synaptic transmission, GABAergic (GO:0032228)2.49637949
97chromosome segregation (GO:0007059)2.49448636
98mitotic cell cycle arrest (GO:0071850)2.48994643
99DNA strand elongation (GO:0022616)2.48645420
100DNA strand elongation involved in DNA replication (GO:0006271)2.48326239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.55773610
2E2F7_22180533_ChIP-Seq_HELA_Human6.15162205
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.44133211
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98487915
5EZH2_22144423_ChIP-Seq_EOC_Human3.54393343
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.32606424
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10676309
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.77014510
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.21920686
10ELK1_19687146_ChIP-ChIP_HELA_Human2.18646954
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.13870289
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.04690306
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.02001245
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00230381
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93675334
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93002052
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83371172
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80264875
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80251139
20AR_21909140_ChIP-Seq_LNCAP_Human1.79489859
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79039486
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78415562
23TAF15_26573619_Chip-Seq_HEK293_Human1.75598728
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70123010
25EWS_26573619_Chip-Seq_HEK293_Human1.61566701
26GBX2_23144817_ChIP-Seq_PC3_Human1.60439248
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54918648
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50742255
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.49969487
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46466301
31VDR_23849224_ChIP-Seq_CD4+_Human1.46150850
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.45074331
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40873129
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.36947345
35TTF2_22483619_ChIP-Seq_HELA_Human1.36279319
36FUS_26573619_Chip-Seq_HEK293_Human1.35780299
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35170409
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33049954
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31864128
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30810881
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29195057
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28588981
43FOXP3_21729870_ChIP-Seq_TREG_Human1.27000681
44ZNF274_21170338_ChIP-Seq_K562_Hela1.23591591
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21810710
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21391879
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20915540
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.16443894
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15834318
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12765429
51E2F1_17053090_ChIP-ChIP_MCF-7_Human1.12245231
52LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11848712
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.11103456
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11010695
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09055775
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09006075
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.08708627
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07149156
59P300_19829295_ChIP-Seq_ESCs_Human1.07056609
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06644646
61SMAD4_21799915_ChIP-Seq_A2780_Human1.05437030
62RNF2_27304074_Chip-Seq_NSC_Mouse1.05191931
63CBP_20019798_ChIP-Seq_JUKART_Human1.04865807
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04865807
65XRN2_22483619_ChIP-Seq_HELA_Human1.03931008
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03756759
67TP53_22573176_ChIP-Seq_HFKS_Human1.02940325
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01964668
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01311068
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00825375
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00603897
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00494528
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00353085
74POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99667752
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99026255
76EZH2_27294783_Chip-Seq_NPCs_Mouse0.98308542
77NANOG_18555785_Chip-Seq_ESCs_Mouse0.97985227
78ETS1_20019798_ChIP-Seq_JURKAT_Human0.97720999
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97500548
80VDR_22108803_ChIP-Seq_LS180_Human0.97414152
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97248705
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95987738
83SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94704636
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92717915
85CDX2_22108803_ChIP-Seq_LS180_Human0.92176002
86DCP1A_22483619_ChIP-Seq_HELA_Human0.92066434
87NANOG_19829295_ChIP-Seq_ESCs_Human0.90622011
88SOX2_19829295_ChIP-Seq_ESCs_Human0.90622011
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90547877
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89788569
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88825980
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.88343539
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86102441
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85402588
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.84797727
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84439829
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.84334783
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84083953
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83973017
100TP53_16413492_ChIP-PET_HCT116_Human0.81423058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.52020218
2MP0003183_abnormal_peptide_metabolism4.13583446
3MP0008057_abnormal_DNA_replication3.55438688
4MP0003646_muscle_fatigue3.01208732
5MP0001879_abnormal_lymphatic_vessel2.95624539
6MP0003693_abnormal_embryo_hatching2.80345479
7MP0002163_abnormal_gland_morphology2.77624723
8MP0005423_abnormal_somatic_nervous2.76445315
9MP0001529_abnormal_vocalization2.64149426
10MP0003880_abnormal_central_pattern2.55457720
11MP0009840_abnormal_foam_cell2.41789322
12MP0002089_abnormal_postnatal_growth/wei2.40609607
13MP0010094_abnormal_chromosome_stability2.29761271
14MP0004142_abnormal_muscle_tone2.19468316
15MP0010368_abnormal_lymphatic_system2.10910701
16MP0002138_abnormal_hepatobiliary_system2.02236417
17MP0003890_abnormal_embryonic-extraembry2.00729456
18MP0004270_analgesia1.99121023
19MP0002139_abnormal_hepatobiliary_system1.97114776
20MP0003111_abnormal_nucleus_morphology1.95195181
21MP0005379_endocrine/exocrine_gland_phen1.94395597
22MP0001485_abnormal_pinna_reflex1.82322872
23MP0002938_white_spotting1.80031298
24MP0003077_abnormal_cell_cycle1.78781616
25MP0005646_abnormal_pituitary_gland1.62803420
26MP0003718_maternal_effect1.60970214
27MP0005171_absent_coat_pigmentation1.54394492
28MP0000537_abnormal_urethra_morphology1.53090898
29MP0004145_abnormal_muscle_electrophysio1.52600741
30MP0009046_muscle_twitch1.50853596
31MP0005645_abnormal_hypothalamus_physiol1.46222637
32MP0001968_abnormal_touch/_nociception1.42880822
33MP0002736_abnormal_nociception_after1.42376875
34MP0009250_abnormal_appendicular_skeleto1.41640637
35MP0002653_abnormal_ependyma_morphology1.36393029
36MP0002102_abnormal_ear_morphology1.29238235
37MP0004957_abnormal_blastocyst_morpholog1.25734379
38MP0008058_abnormal_DNA_repair1.25526225
39MP0003567_abnormal_fetal_cardiomyocyte1.25203926
40MP0001299_abnormal_eye_distance/1.23116447
41MP0005084_abnormal_gallbladder_morpholo1.22310158
42MP0000049_abnormal_middle_ear1.21735779
43MP0000372_irregular_coat_pigmentation1.21456723
44MP0004742_abnormal_vestibular_system1.19306976
45MP0006035_abnormal_mitochondrial_morpho1.17574377
46MP0010030_abnormal_orbit_morphology1.17158260
47MP0000534_abnormal_ureter_morphology1.15401215
48MP0000631_abnormal_neuroendocrine_gland1.11016173
49MP0005551_abnormal_eye_electrophysiolog1.10636004
50MP0002971_abnormal_brown_adipose1.10296320
51MP0003045_fibrosis1.07878725
52MP0005174_abnormal_tail_pigmentation1.07345421
53MP0005253_abnormal_eye_physiology1.03683415
54MP0001764_abnormal_homeostasis1.03315329
55MP0004134_abnormal_chest_morphology1.03085869
56MP0001293_anophthalmia1.02378225
57MP0005332_abnormal_amino_acid1.01709265
58MP0002932_abnormal_joint_morphology1.00216032
59MP0003806_abnormal_nucleotide_metabolis0.97979872
60MP0000371_diluted_coat_color0.96590073
61MP0003943_abnormal_hepatobiliary_system0.94784591
62MP0004019_abnormal_vitamin_homeostasis0.94463306
63MP0006054_spinal_hemorrhage0.93749818
64MP0001324_abnormal_eye_pigmentation0.91871199
65MP0002108_abnormal_muscle_morphology0.88595336
66MP0002229_neurodegeneration0.87981560
67MP0003935_abnormal_craniofacial_develop0.86396648
68MP0001756_abnormal_urination0.85446421
69MP0003941_abnormal_skin_development0.84979266
70MP0003633_abnormal_nervous_system0.80631350
71MP0004883_abnormal_blood_vessel0.80350146
72MP0003632_abnormal_nervous_system0.79120627
73MP0002233_abnormal_nose_morphology0.77695022
74MP0003385_abnormal_body_wall0.77411343
75MP0002734_abnormal_mechanical_nocicepti0.76292030
76MP0003631_nervous_system_phenotype0.75213826
77MP0000750_abnormal_muscle_regeneration0.74725503
78MP0003136_yellow_coat_color0.74133121
79MP0003755_abnormal_palate_morphology0.73542954
80MP0003690_abnormal_glial_cell0.73535121
81MP0000428_abnormal_craniofacial_morphol0.72924907
82MP0000613_abnormal_salivary_gland0.72634528
83MP0002127_abnormal_cardiovascular_syste0.71641294
84MP0004924_abnormal_behavior0.70958678
85MP0005386_behavior/neurological_phenoty0.70958678
86MP0000747_muscle_weakness0.67883779
87MP0005369_muscle_phenotype0.67637148
88MP0003786_premature_aging0.66963298
89MP0002210_abnormal_sex_determination0.66286610
90MP0002067_abnormal_sensory_capabilities0.66043183
91MP0000653_abnormal_sex_gland0.65881899
92MP0002095_abnormal_skin_pigmentation0.64109051
93MP0000015_abnormal_ear_pigmentation0.64089709
94MP0002075_abnormal_coat/hair_pigmentati0.63191357
95MP0000013_abnormal_adipose_tissue0.62739806
96MP0000163_abnormal_cartilage_morphology0.62269154
97MP0005395_other_phenotype0.62107830
98MP0009278_abnormal_bone_marrow0.61713072
99MP0008932_abnormal_embryonic_tissue0.61545660
100MP0002234_abnormal_pharynx_morphology0.60989198

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lumbar spine (HP:0100712)4.30659460
2Vertebral arch anomaly (HP:0008438)4.28073362
3Broad alveolar ridges (HP:0000187)4.09709530
4Unilateral renal agenesis (HP:0000122)4.08591186
5Hypobetalipoproteinemia (HP:0003563)3.71679455
6Amyotrophic lateral sclerosis (HP:0007354)3.54838655
7Meningioma (HP:0002858)3.54832256
8Thoracic kyphosis (HP:0002942)3.44512901
9Thickened calvaria (HP:0002684)3.37988511
10Pheochromocytoma (HP:0002666)3.37624827
11Fibular aplasia (HP:0002990)3.34163868
12Broad ribs (HP:0000885)3.27114794
13Carpal bone hypoplasia (HP:0001498)3.12728722
14Tracheomalacia (HP:0002779)3.02101493
15Abnormal number of erythroid precursors (HP:0012131)2.99497490
16Thoracolumbar scoliosis (HP:0002944)2.96840792
17Diastasis recti (HP:0001540)2.96788698
18Aortic regurgitation (HP:0001659)2.96647158
19Split foot (HP:0001839)2.95807720
20Abnormality of DNA repair (HP:0003254)2.91504442
21High anterior hairline (HP:0009890)2.85171716
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84533751
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.77589316
24Hepatocellular necrosis (HP:0001404)2.76122490
25Dyskinesia (HP:0100660)2.73936888
26Oral leukoplakia (HP:0002745)2.72700721
27Neuroendocrine neoplasm (HP:0100634)2.66452628
28Anomalous pulmonary venous return (HP:0010772)2.65820591
29Duplicated collecting system (HP:0000081)2.62868186
30J-shaped sella turcica (HP:0002680)2.57223184
31Asymmetry of the thorax (HP:0001555)2.55043336
32Methylmalonic acidemia (HP:0002912)2.47555527
33Intestinal atresia (HP:0011100)2.46883512
34Decreased lacrimation (HP:0000633)2.46293476
35Premature graying of hair (HP:0002216)2.44503579
36Increased density of long bones (HP:0006392)2.42991837
37Absent radius (HP:0003974)2.36170295
38Abnormality of the pulmonary veins (HP:0011718)2.30822688
39Absent forearm bone (HP:0003953)2.27691674
40Aplasia involving forearm bones (HP:0009822)2.27691674
41Esophageal neoplasm (HP:0100751)2.27187494
42Neoplasm of head and neck (HP:0012288)2.27187494
43Oligodactyly (hands) (HP:0001180)2.27033687
44Joint hemorrhage (HP:0005261)2.26458086
45Focal motor seizures (HP:0011153)2.22022139
46Aqueductal stenosis (HP:0002410)2.19202414
47Increased hepatocellular lipid droplets (HP:0006565)2.16694370
48Wide intermamillary distance (HP:0006610)2.13986245
49Abnormality of the renal collecting system (HP:0004742)2.12090651
50Abnormality of the thoracic spine (HP:0100711)2.11824524
51Benign neoplasm of the central nervous system (HP:0100835)2.11368214
52Abnormality of cells of the erythroid lineage (HP:0012130)2.10690522
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.08520028
54Abnormality of the nasal septum (HP:0000419)2.07420498
55Abnormality of the labia minora (HP:0012880)2.05365177
56Recurrent corneal erosions (HP:0000495)2.04965925
57Hepatic necrosis (HP:0002605)2.01007387
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.00472309
59Dry hair (HP:0011359)1.98719136
60Meckel diverticulum (HP:0002245)1.98559769
61Cavernous hemangioma (HP:0001048)1.94525893
62Nephronophthisis (HP:0000090)1.94491348
63Stenosis of the external auditory canal (HP:0000402)1.94370351
64Abnormality of the ileum (HP:0001549)1.93815412
65Partial agenesis of the corpus callosum (HP:0001338)1.93650851
66Long clavicles (HP:0000890)1.92357093
67Deformed sella turcica (HP:0002681)1.90338497
68Abnormality of the odontoid process (HP:0003310)1.89444606
69Oligodactyly (HP:0012165)1.89063272
70Abnormality of liposaccharide metabolism (HP:0010968)1.88979743
71Abnormality of glycosphingolipid metabolism (HP:0004343)1.88979743
72Abnormality of glycolipid metabolism (HP:0010969)1.88979743
73Abnormality of pyrimidine metabolism (HP:0004353)1.88612609
74Neoplasm of the peripheral nervous system (HP:0100007)1.88166224
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88030212
76Short 4th metacarpal (HP:0010044)1.88030212
77Hyperventilation (HP:0002883)1.87927907
78Genetic anticipation (HP:0003743)1.87798657
79Attenuation of retinal blood vessels (HP:0007843)1.86873951
80Chromsome breakage (HP:0040012)1.86132716
81Bony spicule pigmentary retinopathy (HP:0007737)1.84233944
82Dysautonomia (HP:0002459)1.84220848
83Abnormality of the lower motor neuron (HP:0002366)1.82778440
84Abnormality of chromosome stability (HP:0003220)1.82311191
85Abnormality of vitamin B metabolism (HP:0004340)1.81913906
86Duplication of thumb phalanx (HP:0009942)1.81445410
87Beaking of vertebral bodies (HP:0004568)1.81219763
88Microtia (HP:0008551)1.80998346
89Abnormality of the preputium (HP:0100587)1.80996492
90Abnormality of the intervertebral disk (HP:0005108)1.79414678
91Fibular hypoplasia (HP:0003038)1.77510578
92Subaortic stenosis (HP:0001682)1.75334717
93Abnormality of the left ventricular outflow tract (HP:0011103)1.75334717
94Abnormality of the vitamin B12 metabolism (HP:0004341)1.74732232
95Curly hair (HP:0002212)1.74219762
96Cystic hygroma (HP:0000476)1.69923275
97Abnormality of the 4th metacarpal (HP:0010012)1.68326334
98Renal Fanconi syndrome (HP:0001994)1.66519995
99Abnormality of the sella turcica (HP:0002679)1.66134831
100Scotoma (HP:0000575)1.65241695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.08202458
2TIE13.75127944
3WNK33.56546237
4TAF13.45116935
5MUSK3.41391737
6PIK3CG2.91266951
7TNIK2.82379259
8WEE12.81080858
9NUAK12.72104408
10VRK22.59925869
11BUB12.49024326
12LATS12.48342929
13STK102.31198839
14ACVR1B2.20474719
15PBK2.05003012
16TTK2.04024695
17BRSK21.93091523
18BRSK11.59855320
19BMPR1B1.52915102
20UHMK11.52445513
21CAMK41.45662717
22BRD41.45570525
23PIM21.43080712
24MAP2K31.38395873
25DYRK21.36849547
26MKNK21.35652458
27SCYL21.25869436
28TGFBR11.25611974
29YES11.23324035
30CAMKK21.22358620
31MARK11.13296219
32CLK11.11433738
33MKNK11.09028724
34STK381.08135302
35VRK11.07667756
36MELK1.06870624
37ADRBK11.04440734
38PNCK1.04120097
39MAP3K21.03726302
40MAPKAPK51.03386155
41MST40.99688048
42AURKB0.99183102
43PIM10.98515310
44NEK20.97393022
45MAPK130.91235586
46HIPK20.90870395
47OBSCN0.90085616
48BCKDK0.88196935
49MAP2K60.83531019
50NLK0.83312587
51CDK80.77874463
52NME10.77532443
53CDK40.74914608
54WNK40.72954099
55STK38L0.67740074
56PLK10.65828562
57AURKA0.62716236
58FGFR20.62546486
59MAP3K80.61184498
60PLK30.55309186
61EIF2AK20.53064923
62PLK40.51773627
63KSR10.51508662
64GRK50.50397526
65SRPK10.49810473
66STK110.49322936
67PRKCG0.48882394
68ATR0.47893660
69EPHA30.45903349
70RAF10.44470830
71CASK0.43534036
72ZAK0.42285803
73PLK20.41647871
74CHEK20.41349919
75PHKG10.40804337
76PHKG20.40804337
77MAP3K40.40749733
78AKT20.40390812
79TEC0.39835235
80GRK10.38272847
81PRKCQ0.35315090
82CCNB10.33841238
83CDK120.33299309
84PKN10.31616803
85STK30.28108970
86CDK10.28057420
87LRRK20.26515823
88MAPK70.26394056
89PDGFRA0.25861897
90ROCK20.24465918
91RPS6KA60.23911483
92FGFR10.23519245
93CHEK10.23234855
94TGFBR20.23170335
95CAMK10.22131334
96KDR0.22025038
97BCR0.21830347
98RPS6KA40.21212856
99CSNK1G20.20734014
100CDK60.20581183

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004504.35150629
2Fanconi anemia pathway_Homo sapiens_hsa034603.52016799
3DNA replication_Homo sapiens_hsa030302.92175973
4Mismatch repair_Homo sapiens_hsa034302.79980965
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66913769
6Homologous recombination_Homo sapiens_hsa034402.66299258
7Vitamin digestion and absorption_Homo sapiens_hsa049772.53146746
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.51821632
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33740627
10RNA polymerase_Homo sapiens_hsa030202.26226926
11Sulfur metabolism_Homo sapiens_hsa009202.25271515
12Cell cycle_Homo sapiens_hsa041102.16016337
13Oxidative phosphorylation_Homo sapiens_hsa001902.09792537
14Huntingtons disease_Homo sapiens_hsa050162.09256791
15Parkinsons disease_Homo sapiens_hsa050122.00146153
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99229955
17Proteasome_Homo sapiens_hsa030501.79838090
18Spliceosome_Homo sapiens_hsa030401.76874447
19Alzheimers disease_Homo sapiens_hsa050101.76543012
20Base excision repair_Homo sapiens_hsa034101.75228197
21Nucleotide excision repair_Homo sapiens_hsa034201.59913441
22Basal cell carcinoma_Homo sapiens_hsa052171.59193107
23Dorso-ventral axis formation_Homo sapiens_hsa043201.58367314
24Hedgehog signaling pathway_Homo sapiens_hsa043401.52792113
25Propanoate metabolism_Homo sapiens_hsa006401.51370086
26Glutathione metabolism_Homo sapiens_hsa004801.48022923
27Pyrimidine metabolism_Homo sapiens_hsa002401.41912731
28N-Glycan biosynthesis_Homo sapiens_hsa005101.38263265
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37869205
30RNA degradation_Homo sapiens_hsa030181.32030103
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.31471979
32RNA transport_Homo sapiens_hsa030131.25987328
33Basal transcription factors_Homo sapiens_hsa030221.25920490
34Purine metabolism_Homo sapiens_hsa002301.18478241
35Folate biosynthesis_Homo sapiens_hsa007901.10421394
36Oocyte meiosis_Homo sapiens_hsa041141.09875126
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09218297
38Taste transduction_Homo sapiens_hsa047421.07772235
39Protein export_Homo sapiens_hsa030601.06311814
40Wnt signaling pathway_Homo sapiens_hsa043101.06286348
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05625431
42Non-homologous end-joining_Homo sapiens_hsa034501.04791825
43Hippo signaling pathway_Homo sapiens_hsa043901.03887008
44Sphingolipid metabolism_Homo sapiens_hsa006001.02949242
45Circadian rhythm_Homo sapiens_hsa047101.00104537
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99404846
47mRNA surveillance pathway_Homo sapiens_hsa030150.98455953
48Glutamatergic synapse_Homo sapiens_hsa047240.95802675
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95639380
50Bladder cancer_Homo sapiens_hsa052190.86933883
51MicroRNAs in cancer_Homo sapiens_hsa052060.86142377
52Ribosome_Homo sapiens_hsa030100.85177043
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77834449
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74724820
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74704180
56Axon guidance_Homo sapiens_hsa043600.73325524
57Gap junction_Homo sapiens_hsa045400.67012692
58FoxO signaling pathway_Homo sapiens_hsa040680.61646068
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.61181653
60Inositol phosphate metabolism_Homo sapiens_hsa005620.60619839
61p53 signaling pathway_Homo sapiens_hsa041150.60445292
62HTLV-I infection_Homo sapiens_hsa051660.60179147
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59527690
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58320156
65One carbon pool by folate_Homo sapiens_hsa006700.57641564
66Nitrogen metabolism_Homo sapiens_hsa009100.56979645
67Linoleic acid metabolism_Homo sapiens_hsa005910.56765101
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55582818
69Alcoholism_Homo sapiens_hsa050340.55188859
70Serotonergic synapse_Homo sapiens_hsa047260.53870321
71Cardiac muscle contraction_Homo sapiens_hsa042600.52398291
72ABC transporters_Homo sapiens_hsa020100.51657771
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49802615
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49026102
75Renin secretion_Homo sapiens_hsa049240.47622740
76Calcium signaling pathway_Homo sapiens_hsa040200.47571693
77Circadian entrainment_Homo sapiens_hsa047130.47066578
78Fatty acid elongation_Homo sapiens_hsa000620.46598959
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45961552
80Metabolic pathways_Homo sapiens_hsa011000.41886277
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41678245
82Oxytocin signaling pathway_Homo sapiens_hsa049210.41128737
83GABAergic synapse_Homo sapiens_hsa047270.38658131
84Regulation of autophagy_Homo sapiens_hsa041400.36227454
85Melanogenesis_Homo sapiens_hsa049160.35679776
86TGF-beta signaling pathway_Homo sapiens_hsa043500.31950473
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29905767
88Morphine addiction_Homo sapiens_hsa050320.29854763
89Chemical carcinogenesis_Homo sapiens_hsa052040.29100541
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29055714
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28199020
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26353919
93Nicotine addiction_Homo sapiens_hsa050330.25662323
94Ether lipid metabolism_Homo sapiens_hsa005650.25479321
95MAPK signaling pathway_Homo sapiens_hsa040100.24817493
96Caffeine metabolism_Homo sapiens_hsa002320.24463886
97Amphetamine addiction_Homo sapiens_hsa050310.21068154
98Primary immunodeficiency_Homo sapiens_hsa053400.20864423
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.20853484
100Salivary secretion_Homo sapiens_hsa049700.20707848

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