ZNF286A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.07839035
2chromatin remodeling at centromere (GO:0031055)4.16112017
3regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.01393139
4regulation of mitotic spindle checkpoint (GO:1903504)4.01393139
5replication fork processing (GO:0031297)3.98270748
6DNA replication checkpoint (GO:0000076)3.85051120
7CENP-A containing nucleosome assembly (GO:0034080)3.84193113
8limb bud formation (GO:0060174)3.81220400
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.70987611
10histone exchange (GO:0043486)3.60039895
11regulation of nuclear cell cycle DNA replication (GO:0033262)3.47345776
12DNA catabolic process, exonucleolytic (GO:0000738)3.46143595
13DNA ligation (GO:0006266)3.40363753
14histone H2A acetylation (GO:0043968)3.39730196
15cullin deneddylation (GO:0010388)3.33890090
16negative regulation of translation, ncRNA-mediated (GO:0040033)3.30156931
17regulation of translation, ncRNA-mediated (GO:0045974)3.30156931
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30156931
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19157861
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.19157861
21non-recombinational repair (GO:0000726)3.18736374
22double-strand break repair via nonhomologous end joining (GO:0006303)3.18736374
23pyrimidine nucleobase catabolic process (GO:0006208)3.18536900
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18175188
25DNA replication-dependent nucleosome assembly (GO:0006335)3.16221172
26DNA replication-dependent nucleosome organization (GO:0034723)3.16221172
27DNA replication-independent nucleosome organization (GO:0034724)3.15236916
28DNA replication-independent nucleosome assembly (GO:0006336)3.15236916
29spindle checkpoint (GO:0031577)3.13584972
30DNA damage response, detection of DNA damage (GO:0042769)3.11724116
31kinetochore organization (GO:0051383)3.10265814
32neural tube formation (GO:0001841)3.09958665
33regulation of DNA endoreduplication (GO:0032875)3.08898408
34presynaptic membrane assembly (GO:0097105)3.07528125
35kinetochore assembly (GO:0051382)3.03866262
36mitotic spindle checkpoint (GO:0071174)3.02661472
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00295185
38protein deneddylation (GO:0000338)2.99236572
39negative regulation of DNA recombination (GO:0045910)2.97912495
40regulation of centriole replication (GO:0046599)2.93349797
41postreplication repair (GO:0006301)2.90112390
42presynaptic membrane organization (GO:0097090)2.89338258
43synapsis (GO:0007129)2.88895184
44proteasome assembly (GO:0043248)2.87455892
45recombinational repair (GO:0000725)2.84544526
46regulation of helicase activity (GO:0051095)2.83449236
47centriole replication (GO:0007099)2.82508162
48double-strand break repair via homologous recombination (GO:0000724)2.82486114
49microtubule depolymerization (GO:0007019)2.81540888
50negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81034365
51negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81034365
52negative regulation of mitotic sister chromatid separation (GO:2000816)2.81034365
53negative regulation of sister chromatid segregation (GO:0033046)2.81034365
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81034365
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80623474
56sympathetic nervous system development (GO:0048485)2.80613187
57establishment of integrated proviral latency (GO:0075713)2.80085785
58resolution of meiotic recombination intermediates (GO:0000712)2.77529812
59metaphase plate congression (GO:0051310)2.76847687
60atrial cardiac muscle cell action potential (GO:0086014)2.76706371
61mitotic sister chromatid cohesion (GO:0007064)2.75636016
62somite development (GO:0061053)2.73226533
63somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72360208
64isotype switching (GO:0045190)2.72360208
65somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72360208
66negative regulation of chromosome segregation (GO:0051985)2.71896061
67olfactory bulb development (GO:0021772)2.71260648
68DNA strand elongation involved in DNA replication (GO:0006271)2.69919662
69response to X-ray (GO:0010165)2.69381726
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67198398
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66514167
72response to pheromone (GO:0019236)2.66085253
73telomere maintenance via semi-conservative replication (GO:0032201)2.65417158
74mitotic metaphase plate congression (GO:0007080)2.64894569
75intraciliary transport (GO:0042073)2.63881475
76protein localization to kinetochore (GO:0034501)2.63563169
77mitotic recombination (GO:0006312)2.63455122
78glial cell proliferation (GO:0014009)2.63258212
79regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.62051598
80mitochondrial DNA replication (GO:0006264)2.61268773
81mitotic spindle assembly checkpoint (GO:0007094)2.60587056
82negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59859828
83purine nucleobase biosynthetic process (GO:0009113)2.59793426
84spindle assembly checkpoint (GO:0071173)2.58225724
85regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56650124
86regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56650124
87regulation of mitotic sister chromatid separation (GO:0010965)2.56105192
88regulation of mitotic sister chromatid segregation (GO:0033047)2.56105192
89regulation of sister chromatid segregation (GO:0033045)2.56105192
90DNA strand elongation (GO:0022616)2.53526429
91respiratory chain complex IV assembly (GO:0008535)2.51841905
92telomere maintenance via telomerase (GO:0007004)2.49713165
93protein K6-linked ubiquitination (GO:0085020)2.49246273
94regulation of telomere maintenance (GO:0032204)2.49153948
95DNA-dependent DNA replication (GO:0006261)2.46464771
96female gonad development (GO:0008585)2.46411527
97nucleobase catabolic process (GO:0046113)2.46183093
98sister chromatid segregation (GO:0000819)2.44525401
99DNA recombination (GO:0006310)2.43670183
100lysine metabolic process (GO:0006553)2.43459317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.10483540
2E2F7_22180533_ChIP-Seq_HELA_Human3.64873259
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27091021
4ZNF274_21170338_ChIP-Seq_K562_Hela3.00772626
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88688488
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74127269
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71571371
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48840486
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.45987515
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.42910982
11VDR_22108803_ChIP-Seq_LS180_Human2.40330944
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39156212
13FUS_26573619_Chip-Seq_HEK293_Human2.32586378
14EWS_26573619_Chip-Seq_HEK293_Human2.31829612
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30213076
16IGF1R_20145208_ChIP-Seq_DFB_Human2.26401432
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26184552
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25237178
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24398706
20GBX2_23144817_ChIP-Seq_PC3_Human2.17221732
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13098499
22ELK1_19687146_ChIP-ChIP_HELA_Human2.12445575
23POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07677707
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.07210205
25TAF15_26573619_Chip-Seq_HEK293_Human2.03280866
26P300_19829295_ChIP-Seq_ESCs_Human2.01107282
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92248594
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.90313331
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80199081
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79823413
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73992114
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64113564
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60239572
34MYC_18940864_ChIP-ChIP_HL60_Human1.58090051
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55253663
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55201890
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51698289
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49820755
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49363216
40VDR_23849224_ChIP-Seq_CD4+_Human1.43081758
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36886452
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36548931
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32855742
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.32269895
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30902141
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.30436447
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30050046
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29706505
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28917506
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28727426
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.28186003
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.27351989
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27257918
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.25733095
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.25466710
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24547368
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.24207443
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24158016
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23960015
60SMAD4_21799915_ChIP-Seq_A2780_Human1.23796502
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23105842
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.20918925
63IRF1_19129219_ChIP-ChIP_H3396_Human1.19804790
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19184738
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.19066979
66AR_21909140_ChIP-Seq_LNCAP_Human1.18844664
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18689624
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18466519
69BCAT_22108803_ChIP-Seq_LS180_Human1.17428556
70FOXP3_21729870_ChIP-Seq_TREG_Human1.17227868
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17129658
72CBP_20019798_ChIP-Seq_JUKART_Human1.16819590
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16819590
74ER_23166858_ChIP-Seq_MCF-7_Human1.12314820
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11599567
76* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09361767
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08512682
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07806066
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.06850942
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.06691517
81RNF2_27304074_Chip-Seq_NSC_Mouse1.06325625
82TCF4_22108803_ChIP-Seq_LS180_Human1.06120868
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04409565
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04080823
85AR_25329375_ChIP-Seq_VCAP_Human1.01198895
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00385575
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00318915
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00018247
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00018247
90STAT3_23295773_ChIP-Seq_U87_Human0.99876327
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.97974203
92TCF4_23295773_ChIP-Seq_U87_Human0.97172267
93NANOG_19829295_ChIP-Seq_ESCs_Human0.96920719
94SOX2_19829295_ChIP-Seq_ESCs_Human0.96920719
95P53_22387025_ChIP-Seq_ESCs_Mouse0.95557436
96RUNX2_22187159_ChIP-Seq_PCA_Human0.94645913
97MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94415625
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92930741
99P300_18555785_Chip-Seq_ESCs_Mouse0.92867602
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92728510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.07046274
2MP0010094_abnormal_chromosome_stability2.93947811
3MP0006292_abnormal_olfactory_placode2.91410264
4MP0008877_abnormal_DNA_methylation2.90901256
5MP0002102_abnormal_ear_morphology2.81074339
6MP0003693_abnormal_embryo_hatching2.57381256
7MP0003880_abnormal_central_pattern2.55160848
8MP0002938_white_spotting2.17925891
9MP0003121_genomic_imprinting2.16009654
10MP0003787_abnormal_imprinting2.12807908
11MP0002751_abnormal_autonomic_nervous2.09456641
12MP0008057_abnormal_DNA_replication2.07448378
13MP0008789_abnormal_olfactory_epithelium2.05902561
14MP0001529_abnormal_vocalization1.94828172
15MP0003890_abnormal_embryonic-extraembry1.94270677
16MP0001293_anophthalmia1.91629426
17MP0000516_abnormal_urinary_system1.87541283
18MP0005367_renal/urinary_system_phenotyp1.87541283
19MP0003718_maternal_effect1.85558915
20MP0002736_abnormal_nociception_after1.82980453
21MP0003111_abnormal_nucleus_morphology1.77445174
22MP0003122_maternal_imprinting1.70252861
23MP0002234_abnormal_pharynx_morphology1.68780312
24MP0005394_taste/olfaction_phenotype1.67477097
25MP0005499_abnormal_olfactory_system1.67477097
26MP0004957_abnormal_blastocyst_morpholog1.66892384
27MP0003937_abnormal_limbs/digits/tail_de1.65750798
28MP0003567_abnormal_fetal_cardiomyocyte1.63635692
29MP0008932_abnormal_embryonic_tissue1.62884000
30MP0006072_abnormal_retinal_apoptosis1.62324726
31MP0000778_abnormal_nervous_system1.60450735
32MP0002233_abnormal_nose_morphology1.59323934
33MP0003195_calcinosis1.54366471
34MP0003119_abnormal_digestive_system1.52752906
35MP0001984_abnormal_olfaction1.50279061
36MP0003941_abnormal_skin_development1.47787377
37MP0000372_irregular_coat_pigmentation1.47475542
38MP0003077_abnormal_cell_cycle1.46804113
39MP0005253_abnormal_eye_physiology1.42369251
40MP0004133_heterotaxia1.40206880
41MP0009697_abnormal_copulation1.39936897
42MP0008007_abnormal_cellular_replicative1.36529868
43MP0001188_hyperpigmentation1.36149895
44MP0000049_abnormal_middle_ear1.33784222
45MP0005551_abnormal_eye_electrophysiolog1.32809017
46MP0010030_abnormal_orbit_morphology1.32348782
47MP0000631_abnormal_neuroendocrine_gland1.31211500
48MP0003755_abnormal_palate_morphology1.27372137
49MP0001968_abnormal_touch/_nociception1.26715927
50MP0001177_atelectasis1.24410481
51MP0001286_abnormal_eye_development1.17474594
52MP0003136_yellow_coat_color1.17313036
53MP0001486_abnormal_startle_reflex1.13597954
54MP0000647_abnormal_sebaceous_gland1.09820572
55MP0003938_abnormal_ear_development1.06622727
56MP0005248_abnormal_Harderian_gland1.06346077
57MP0006276_abnormal_autonomic_nervous1.05509619
58MP0002254_reproductive_system_inflammat1.05239889
59MP0009703_decreased_birth_body1.02715998
60MP0003861_abnormal_nervous_system1.02012231
61MP0001485_abnormal_pinna_reflex1.01035539
62MP0005391_vision/eye_phenotype1.00991952
63MP0003786_premature_aging1.00021327
64MP0001929_abnormal_gametogenesis0.99935398
65MP0002184_abnormal_innervation0.97302832
66MP0004147_increased_porphyrin_level0.94738427
67MP0002111_abnormal_tail_morphology0.93925861
68MP0005395_other_phenotype0.93454494
69MP0002084_abnormal_developmental_patter0.92486345
70MP0003137_abnormal_impulse_conducting0.91815799
71MP0002697_abnormal_eye_size0.91468426
72MP0004215_abnormal_myocardial_fiber0.90562720
73MP0002210_abnormal_sex_determination0.90441735
74MP0001299_abnormal_eye_distance/0.90237527
75MP0005075_abnormal_melanosome_morpholog0.89890176
76MP0008872_abnormal_physiological_respon0.89206263
77MP0002752_abnormal_somatic_nervous0.87646277
78MP0000653_abnormal_sex_gland0.87124232
79MP0002282_abnormal_trachea_morphology0.86814375
80MP0003935_abnormal_craniofacial_develop0.86431304
81MP0002085_abnormal_embryonic_tissue0.85891206
82MP0002160_abnormal_reproductive_system0.85862619
83MP0005171_absent_coat_pigmentation0.85309536
84MP0001145_abnormal_male_reproductive0.85048614
85MP0006035_abnormal_mitochondrial_morpho0.84865313
86MP0001324_abnormal_eye_pigmentation0.84509415
87MP0004197_abnormal_fetal_growth/weight/0.84112075
88MP0003011_delayed_dark_adaptation0.83560405
89MP0009672_abnormal_birth_weight0.82661816
90MP0000427_abnormal_hair_cycle0.81451147
91MP0005386_behavior/neurological_phenoty0.81135379
92MP0004924_abnormal_behavior0.81135379
93MP0003698_abnormal_male_reproductive0.79550586
94MP0003123_paternal_imprinting0.79132985
95MP0006054_spinal_hemorrhage0.78208334
96MP0002272_abnormal_nervous_system0.76941388
97MP0003385_abnormal_body_wall0.76906283
98MP0005195_abnormal_posterior_eye0.75702573
99MP0002735_abnormal_chemical_nociception0.74108008
100MP0001119_abnormal_female_reproductive0.73157240

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.29510582
2Colon cancer (HP:0003003)3.36129485
3Volvulus (HP:0002580)3.28764620
4Abnormality of chromosome stability (HP:0003220)3.09581690
5Aplasia/Hypoplasia of the uvula (HP:0010293)2.97957645
6Meckel diverticulum (HP:0002245)2.97260424
7Ependymoma (HP:0002888)2.94225128
8Abnormality of the ileum (HP:0001549)2.91199123
9Intestinal atresia (HP:0011100)2.75967889
10Pancreatic cysts (HP:0001737)2.74740777
11Ectopic kidney (HP:0000086)2.67239489
12Abnormality of the astrocytes (HP:0100707)2.67159925
13Astrocytoma (HP:0009592)2.67159925
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66896215
15Glioma (HP:0009733)2.64072942
16Pancreatic fibrosis (HP:0100732)2.61427939
17True hermaphroditism (HP:0010459)2.60558177
18Abnormal lung lobation (HP:0002101)2.56985923
19Abnormality of midbrain morphology (HP:0002418)2.54549551
20Molar tooth sign on MRI (HP:0002419)2.54549551
21Chromsome breakage (HP:0040012)2.53242242
22Abnormality of the preputium (HP:0100587)2.44109594
23Nephronophthisis (HP:0000090)2.31575245
24Medial flaring of the eyebrow (HP:0010747)2.28071570
25Septo-optic dysplasia (HP:0100842)2.26246848
26Rhabdomyosarcoma (HP:0002859)2.24450389
27Hyperglycinemia (HP:0002154)2.23356978
28Sloping forehead (HP:0000340)2.21759676
29Methylmalonic acidemia (HP:0002912)2.21057769
30Small intestinal stenosis (HP:0012848)2.19935600
31Duodenal stenosis (HP:0100867)2.19935600
32Neoplasm of the adrenal cortex (HP:0100641)2.19120575
33Abnormality of the duodenum (HP:0002246)2.17690279
34Renal hypoplasia (HP:0000089)2.14065953
35Pendular nystagmus (HP:0012043)2.13244066
36Genital tract atresia (HP:0001827)2.11319414
37Small hand (HP:0200055)2.09863677
38Bifid tongue (HP:0010297)2.08957911
39Aqueductal stenosis (HP:0002410)2.08835381
40Vaginal atresia (HP:0000148)2.03975238
41Embryonal renal neoplasm (HP:0011794)2.03118918
42Supernumerary spleens (HP:0009799)2.00974970
43Preaxial hand polydactyly (HP:0001177)2.00105827
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99484147
45Aplasia/Hypoplasia of the tongue (HP:0010295)1.99399001
46Optic nerve hypoplasia (HP:0000609)1.98508409
47Chronic hepatic failure (HP:0100626)1.97941448
48Dandy-Walker malformation (HP:0001305)1.96048677
49Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95627550
50Abnormality of the renal medulla (HP:0100957)1.95574995
51Birth length less than 3rd percentile (HP:0003561)1.94578733
52Congenital primary aphakia (HP:0007707)1.94356013
53Abnormality of the metopic suture (HP:0005556)1.92376460
54Abnormality of the parathyroid morphology (HP:0011766)1.92003604
55Patellar aplasia (HP:0006443)1.91952368
56Aplasia/Hypoplasia of the sternum (HP:0006714)1.91915119
57Gait imbalance (HP:0002141)1.91253244
58Nephroblastoma (Wilms tumor) (HP:0002667)1.91246896
59Gonadotropin excess (HP:0000837)1.90273966
60Drooling (HP:0002307)1.89693566
61Hypoplastic pelvis (HP:0008839)1.89239993
62Medulloblastoma (HP:0002885)1.89196906
63Triphalangeal thumb (HP:0001199)1.87603753
64Postaxial hand polydactyly (HP:0001162)1.87169830
65Narrow forehead (HP:0000341)1.86988739
66Neoplasm of the adrenal gland (HP:0100631)1.86636133
67Nephrogenic diabetes insipidus (HP:0009806)1.86211176
68Hypoplastic female external genitalia (HP:0012815)1.85117318
69Lissencephaly (HP:0001339)1.84217118
70Anophthalmia (HP:0000528)1.81755065
71Anencephaly (HP:0002323)1.80456442
72Sclerocornea (HP:0000647)1.79397425
73Gastrointestinal atresia (HP:0002589)1.79238178
74Labial hypoplasia (HP:0000066)1.78737334
75Absent radius (HP:0003974)1.78504331
76Neoplasm of the oral cavity (HP:0100649)1.78330069
77Stenosis of the external auditory canal (HP:0000402)1.77699287
78Oligodactyly (hands) (HP:0001180)1.77499491
79Astigmatism (HP:0000483)1.76798369
80Abnormality of the carotid arteries (HP:0005344)1.74999444
81Hyperinsulinemic hypoglycemia (HP:0000825)1.74233071
82Abnormality of serine family amino acid metabolism (HP:0010894)1.73960933
83Abnormality of glycine metabolism (HP:0010895)1.73960933
84Clubbing of toes (HP:0100760)1.73768551
85Aplasia/Hypoplasia of the patella (HP:0006498)1.73155517
86Progressive inability to walk (HP:0002505)1.71963983
87Postaxial foot polydactyly (HP:0001830)1.71955855
88Absent forearm bone (HP:0003953)1.70808057
89Aplasia involving forearm bones (HP:0009822)1.70808057
90Pancreatic islet-cell hyperplasia (HP:0004510)1.70307711
91Broad-based gait (HP:0002136)1.69276195
92Hyperglycinuria (HP:0003108)1.68673937
93Cortical dysplasia (HP:0002539)1.68138212
94Abnormal hair whorl (HP:0010721)1.67993119
95Hemivertebrae (HP:0002937)1.67777947
96Abnormality of methionine metabolism (HP:0010901)1.67713476
97Abnormality of serum amino acid levels (HP:0003112)1.66947725
98Cupped ear (HP:0000378)1.66339679
99Absent septum pellucidum (HP:0001331)1.66233614
100Methylmalonic aciduria (HP:0012120)1.65769153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.85083619
2TRIM283.72807608
3TNIK3.56189689
4MKNK22.80317131
5BUB12.53559676
6FRK2.52713328
7MKNK12.31676668
8NUAK12.31368345
9MAP4K22.23169304
10PLK32.19294936
11BMPR1B2.14667358
12EIF2AK32.13002281
13WEE12.04072615
14SRPK12.01412955
15CDC71.95535465
16TTK1.94559752
17EPHA41.93769105
18TSSK61.92439058
19ZAK1.90564952
20BCR1.89216958
21PNCK1.88669029
22PLK41.83845182
23ERBB31.83341372
24CASK1.77468080
25BRSK21.74889756
26PLK21.62572941
27ACVR1B1.49792436
28MAPK131.48414452
29MAP3K41.43973056
30MARK11.37173645
31EIF2AK11.32609275
32PBK1.31449472
33GRK11.30658816
34VRK11.28733485
35NEK11.28461173
36DYRK21.27827695
37PLK11.24629901
38MST41.20613924
39VRK21.18702117
40CSNK1G11.14197408
41TAF11.04801569
42CSNK1G21.04594176
43NLK1.04306412
44STK38L0.98006658
45SIK30.90103001
46CSNK1G30.89830346
47FGFR20.88508725
48INSRR0.87287167
49ATR0.85430444
50MAP2K70.85282955
51MINK10.83536122
52TGFBR10.82966595
53OXSR10.82323280
54BRSK10.79784780
55AKT30.77403144
56CSNK1A1L0.75881805
57ATM0.75335365
58PAK30.75284024
59EIF2AK20.70812600
60STK160.70655444
61BRD40.70451783
62ADRBK20.70435702
63PRKCG0.67929644
64PRKCE0.66147107
65CHEK20.64664867
66FGFR10.58473639
67STK390.55853590
68STK30.54446241
69DYRK30.53319346
70CDK90.51898923
71TIE10.51660228
72CCNB10.50849225
73CHEK10.50348611
74ERBB40.50152413
75BCKDK0.49607088
76PINK10.48666777
77AURKB0.47468657
78FER0.46034606
79PKN10.45492129
80FLT30.44099230
81EPHB20.41686534
82PRKDC0.41110758
83CSNK1E0.38451293
84CSNK1D0.37086494
85NEK20.36051442
86CDK10.34537882
87CSNK2A10.33862494
88YES10.32316448
89RPS6KA40.31990906
90CDK30.31483814
91CSNK1A10.31447474
92PASK0.27936627
93DYRK1A0.27616362
94NME10.26838227
95CDK20.26517328
96CSNK2A20.22844915
97UHMK10.22584004
98CAMK2A0.22232156
99PRKACB0.21335376
100PRKCI0.20476674

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.20558089
2Mismatch repair_Homo sapiens_hsa034302.93162400
3Proteasome_Homo sapiens_hsa030502.82049820
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81437591
5Fanconi anemia pathway_Homo sapiens_hsa034602.78501369
6Homologous recombination_Homo sapiens_hsa034402.70816431
7DNA replication_Homo sapiens_hsa030302.53598645
8Protein export_Homo sapiens_hsa030602.46209015
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40662390
10Propanoate metabolism_Homo sapiens_hsa006402.39787221
11Basal transcription factors_Homo sapiens_hsa030222.25268335
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18748169
13Steroid biosynthesis_Homo sapiens_hsa001002.09346747
14RNA polymerase_Homo sapiens_hsa030202.07754701
15RNA transport_Homo sapiens_hsa030132.05708155
16RNA degradation_Homo sapiens_hsa030182.02093763
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87357599
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85394811
19Cell cycle_Homo sapiens_hsa041101.82016897
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62889517
21Spliceosome_Homo sapiens_hsa030401.61207365
22Base excision repair_Homo sapiens_hsa034101.59551116
23Butanoate metabolism_Homo sapiens_hsa006501.54541557
24Selenocompound metabolism_Homo sapiens_hsa004501.51866876
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50479002
26Fatty acid elongation_Homo sapiens_hsa000621.47832609
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.47660456
28Nucleotide excision repair_Homo sapiens_hsa034201.46601810
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38788717
30Phototransduction_Homo sapiens_hsa047441.35856848
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30211566
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24375552
33Pyruvate metabolism_Homo sapiens_hsa006201.20541967
34One carbon pool by folate_Homo sapiens_hsa006701.17033491
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16235224
36Nicotine addiction_Homo sapiens_hsa050331.14728235
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10037584
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09960186
39mRNA surveillance pathway_Homo sapiens_hsa030151.06575927
40Oocyte meiosis_Homo sapiens_hsa041141.06433945
41Pyrimidine metabolism_Homo sapiens_hsa002401.02944809
42Basal cell carcinoma_Homo sapiens_hsa052171.01336254
43Hedgehog signaling pathway_Homo sapiens_hsa043400.99351294
44Tryptophan metabolism_Homo sapiens_hsa003800.95069215
45Purine metabolism_Homo sapiens_hsa002300.94265986
46Parkinsons disease_Homo sapiens_hsa050120.92879674
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90330041
48p53 signaling pathway_Homo sapiens_hsa041150.87877741
49Caffeine metabolism_Homo sapiens_hsa002320.86401083
50Lysine degradation_Homo sapiens_hsa003100.85913344
51Oxidative phosphorylation_Homo sapiens_hsa001900.85421777
52Nitrogen metabolism_Homo sapiens_hsa009100.84961081
53Vitamin B6 metabolism_Homo sapiens_hsa007500.84330354
54Hippo signaling pathway_Homo sapiens_hsa043900.83504046
55Peroxisome_Homo sapiens_hsa041460.81967014
56Ether lipid metabolism_Homo sapiens_hsa005650.79423050
57beta-Alanine metabolism_Homo sapiens_hsa004100.78047797
58Fatty acid metabolism_Homo sapiens_hsa012120.74977896
59Huntingtons disease_Homo sapiens_hsa050160.74217122
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74046189
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70922290
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70658036
63Wnt signaling pathway_Homo sapiens_hsa043100.69550257
64TGF-beta signaling pathway_Homo sapiens_hsa043500.66723556
65Fatty acid degradation_Homo sapiens_hsa000710.62877245
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62089082
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62017879
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58059894
69Taste transduction_Homo sapiens_hsa047420.57133040
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57095680
71Metabolic pathways_Homo sapiens_hsa011000.55814963
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55568544
73Retinol metabolism_Homo sapiens_hsa008300.54579632
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52794193
75Linoleic acid metabolism_Homo sapiens_hsa005910.51776786
76Glutathione metabolism_Homo sapiens_hsa004800.49125706
77Carbon metabolism_Homo sapiens_hsa012000.45168405
78Tight junction_Homo sapiens_hsa045300.44892418
79Biosynthesis of amino acids_Homo sapiens_hsa012300.44512006
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41330536
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40162953
82Regulation of autophagy_Homo sapiens_hsa041400.39208752
83Fat digestion and absorption_Homo sapiens_hsa049750.38098740
84Olfactory transduction_Homo sapiens_hsa047400.37932401
85Chemical carcinogenesis_Homo sapiens_hsa052040.37755838
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37547644
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36978015
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.36679356
89Dopaminergic synapse_Homo sapiens_hsa047280.34022844
90Arginine and proline metabolism_Homo sapiens_hsa003300.33793544
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33447991
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.30549673
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.29607784
94Axon guidance_Homo sapiens_hsa043600.29245114
95Vitamin digestion and absorption_Homo sapiens_hsa049770.27944221
96Colorectal cancer_Homo sapiens_hsa052100.27663126
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27241397
98Sulfur metabolism_Homo sapiens_hsa009200.27111981
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26082075
100Alzheimers disease_Homo sapiens_hsa050100.25588774

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