ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.44807457
2	DNA double-strand break processing (GO:0000729)	4.20194761
3	limb bud formation (GO:0060174)	4.07386179
4	presynaptic membrane assembly (GO:0097105)	4.06853140
5	behavioral response to nicotine (GO:0035095)	3.97549878
6	presynaptic membrane organization (GO:0097090)	3.93126549
7	neural tube formation (GO:0001841)	3.83540915
8	nucleobase catabolic process (GO:0046113)	3.60908560
9	somite development (GO:0061053)	3.50220990
10	replication fork processing (GO:0031297)	3.46199248
11	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.18031255
12	neuron cell-cell adhesion (GO:0007158)	3.17952088
13	protein neddylation (GO:0045116)	3.14087192
14	DNA damage response, detection of DNA damage (GO:0042769)	3.05820900
15	cornea development in camera-type eye (GO:0061303)	3.05265817
16	protein complex biogenesis (GO:0070271)	3.00604128
17	response to pheromone (GO:0019236)	2.95667316
18	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.95264756
19	regulation of mitotic spindle checkpoint (GO:1903504)	2.95264756
20	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.94755300
21	regulation of telomere maintenance (GO:0032204)	2.94137578
22	negative regulation of telomere maintenance (GO:0032205)	2.93957178
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.92898034
24	NADH dehydrogenase complex assembly (GO:0010257)	2.92898034
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.92898034
26	kidney morphogenesis (GO:0060993)	2.91245282
27	sympathetic nervous system development (GO:0048485)	2.88116597
28	gamma-aminobutyric acid transport (GO:0015812)	2.87190188
29	protein polyglutamylation (GO:0018095)	2.85863357
30	spinal cord development (GO:0021510)	2.85832409
31	intraciliary transport (GO:0042073)	2.84568519
32	water-soluble vitamin biosynthetic process (GO:0042364)	2.84556459
33	transmission of nerve impulse (GO:0019226)	2.82241475
34	retinal ganglion cell axon guidance (GO:0031290)	2.81720188
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.81002583
36	platelet dense granule organization (GO:0060155)	2.80669553
37	protein-cofactor linkage (GO:0018065)	2.80122300
38	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.79826634
39	postsynaptic membrane organization (GO:0001941)	2.79414006
40	mitochondrial respiratory chain complex assembly (GO:0033108)	2.79035518
41	cell proliferation in forebrain (GO:0021846)	2.75897945
42	respiratory chain complex IV assembly (GO:0008535)	2.74359899
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72832649
44	nonmotile primary cilium assembly (GO:0035058)	2.72568645
45	centriole replication (GO:0007099)	2.72277849
46	fucose catabolic process (GO:0019317)	2.70639803
47	L-fucose metabolic process (GO:0042354)	2.70639803
48	L-fucose catabolic process (GO:0042355)	2.70639803
49	epithelial cilium movement (GO:0003351)	2.69018490
50	regulation of timing of cell differentiation (GO:0048505)	2.68867937
51	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.68416992
52	regulation of translation, ncRNA-mediated (GO:0045974)	2.68416992
53	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.68416992
54	indolalkylamine metabolic process (GO:0006586)	2.67887797
55	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.67548842
56	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.66078921
57	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.65493637
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65167795
59	resolution of meiotic recombination intermediates (GO:0000712)	2.62345547
60	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.61433538
61	indole-containing compound catabolic process (GO:0042436)	2.61367347
62	indolalkylamine catabolic process (GO:0046218)	2.61367347
63	tryptophan catabolic process (GO:0006569)	2.61367347
64	histone H2A acetylation (GO:0043968)	2.61054552
65	olfactory bulb development (GO:0021772)	2.60559575
66	DNA deamination (GO:0045006)	2.58831970
67	vocalization behavior (GO:0071625)	2.56397341
68	regulation of meiosis I (GO:0060631)	2.55854772
69	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.55292066
70	kynurenine metabolic process (GO:0070189)	2.53637882
71	cullin deneddylation (GO:0010388)	2.53284186
72	chromatin remodeling at centromere (GO:0031055)	2.53125220
73	recombinational repair (GO:0000725)	2.52175713
74	behavioral response to ethanol (GO:0048149)	2.50600598
75	cytochrome complex assembly (GO:0017004)	2.49571381
76	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.49514382
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.49514382
78	double-strand break repair via homologous recombination (GO:0000724)	2.49385641
79	regulation of development, heterochronic (GO:0040034)	2.49329605
80	regulation of cilium movement (GO:0003352)	2.48705287
81	cilium morphogenesis (GO:0060271)	2.48135264
82	cerebral cortex radially oriented cell migration (GO:0021799)	2.46244930
83	axonal fasciculation (GO:0007413)	2.46195525
84	tryptophan metabolic process (GO:0006568)	2.45187640
85	neuron recognition (GO:0008038)	2.44571870
86	regulation of collateral sprouting (GO:0048670)	2.42023007
87	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.38815543
88	glial cell proliferation (GO:0014009)	2.38423313
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.38120000
90	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.38120000
91	retinal cone cell development (GO:0046549)	2.37754682
92	protein localization to cilium (GO:0061512)	2.37324398
93	central nervous system projection neuron axonogenesis (GO:0021952)	2.36453651
94	dendritic spine morphogenesis (GO:0060997)	2.36438713
95	anterograde synaptic vesicle transport (GO:0048490)	2.36251269
96	photoreceptor cell development (GO:0042461)	2.34059452
97	cilium organization (GO:0044782)	2.33952282
98	sulfation (GO:0051923)	2.33218813
99	positive regulation of mitochondrial fission (GO:0090141)	2.33104235
100	DNA catabolic process, exonucleolytic (GO:0000738)	2.32623148

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.57961361
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.21040947
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88567259
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.84609173
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75214177
6	VDR_22108803_ChIP-Seq_LS180_Human	2.68678798
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.54405475
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.52276702
9	FUS_26573619_Chip-Seq_HEK293_Human	2.48389847
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.47981536
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47134888
12	EWS_26573619_Chip-Seq_HEK293_Human	2.45442638
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27320058
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.26829473
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.23631100
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20221471
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.19733159
18	P300_19829295_ChIP-Seq_ESCs_Human	2.17676908
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12994743
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08198939
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.06967541
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.99806894
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.99439508
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96630608
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.95420357
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81551281
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.75481174
28	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.73766397
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.70496374
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63392306
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59245619
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56823186
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56375873
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.55521315
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53772308
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.52651281
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52226730
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49475970
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49268504
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49160760
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47129359
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46911809
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46115911
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.45143562
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43426973
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.42838421
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42838421
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42221344
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39949869
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39069051
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39069051
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38651177
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38348639
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37889662
55	AR_25329375_ChIP-Seq_VCAP_Human	1.36705396
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36206008
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35561213
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31353880
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29033942
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28145135
61	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.27778045
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.26837438
63	STAT3_23295773_ChIP-Seq_U87_Human	1.25989478
64	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25634037
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23081928
66	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.22728620
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21306742
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20529834
69	TCF4_23295773_ChIP-Seq_U87_Human	1.20265614
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.19625205
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18626229
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.18190766
73	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.17826932
74	VDR_23849224_ChIP-Seq_CD4+_Human	1.14851898
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14204245
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13855942
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12242146
78	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12120973
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11349086
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08606268
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08606268
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.07958785
83	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.07334230
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05912790
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03835729
86	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02360605
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02258217
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00842894
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98472747
90	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98296949
91	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.97441809
92	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.97341225
93	JUN_21703547_ChIP-Seq_K562_Human	0.96951441
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95909618
95	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95692167
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95150182
97	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94856819
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.94304852
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93580688
100	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92730489

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.56453641
2	MP0006292_abnormal_olfactory_placode	2.92595825
3	MP0002102_abnormal_ear_morphology	2.86404322
4	MP0008877_abnormal_DNA_methylation	2.68764302
5	MP0003787_abnormal_imprinting	2.41372494
6	MP0002736_abnormal_nociception_after	2.19326947
7	MP0008058_abnormal_DNA_repair	2.05665693
8	MP0001968_abnormal_touch/_nociception	2.01222449
9	MP0000778_abnormal_nervous_system	1.97665163
10	MP0006072_abnormal_retinal_apoptosis	1.90585163
11	MP0005551_abnormal_eye_electrophysiolog	1.89235048
12	MP0002751_abnormal_autonomic_nervous	1.86712520
13	MP0001529_abnormal_vocalization	1.82144645
14	MP0003121_genomic_imprinting	1.80502092
15	MP0000631_abnormal_neuroendocrine_gland	1.80342055
16	MP0008789_abnormal_olfactory_epithelium	1.79797607
17	MP0006276_abnormal_autonomic_nervous	1.75513791
18	MP0002938_white_spotting	1.71498628
19	MP0002234_abnormal_pharynx_morphology	1.64074056
20	MP0005646_abnormal_pituitary_gland	1.63098461
21	MP0001188_hyperpigmentation	1.62752708
22	MP0004885_abnormal_endolymph	1.62276965
23	MP0009745_abnormal_behavioral_response	1.61441690
24	MP0003122_maternal_imprinting	1.59554315
25	MP0005253_abnormal_eye_physiology	1.59015330
26	MP0009046_muscle_twitch	1.58073495
27	MP0002272_abnormal_nervous_system	1.57056955
28	MP0004133_heterotaxia	1.56931184
29	MP0001984_abnormal_olfaction	1.55868201
30	MP0003195_calcinosis	1.55238477
31	MP0001486_abnormal_startle_reflex	1.54363259
32	MP0005367_renal/urinary_system_phenotyp	1.54012970
33	MP0000516_abnormal_urinary_system	1.54012970
34	MP0000049_abnormal_middle_ear	1.52278082
35	MP0003890_abnormal_embryonic-extraembry	1.49032123
36	MP0001485_abnormal_pinna_reflex	1.47858017
37	MP0002735_abnormal_chemical_nociception	1.43581874
38	MP0008872_abnormal_physiological_respon	1.43412541
39	MP0000372_irregular_coat_pigmentation	1.42353294
40	MP0005394_taste/olfaction_phenotype	1.41528404
41	MP0005499_abnormal_olfactory_system	1.41528404
42	MP0002837_dystrophic_cardiac_calcinosis	1.40254895
43	MP0003718_maternal_effect	1.38100500
44	MP0001293_anophthalmia	1.34103412
45	MP0002653_abnormal_ependyma_morphology	1.32846876
46	MP0002638_abnormal_pupillary_reflex	1.32247808
47	MP0003635_abnormal_synaptic_transmissio	1.29568076
48	MP0002184_abnormal_innervation	1.29517939
49	MP0002734_abnormal_mechanical_nocicepti	1.25714439
50	MP0004142_abnormal_muscle_tone	1.25447236
51	MP0005423_abnormal_somatic_nervous	1.24960469
52	MP0005084_abnormal_gallbladder_morpholo	1.24231755
53	MP0005645_abnormal_hypothalamus_physiol	1.24176531
54	MP0004270_analgesia	1.24054521
55	MP0002233_abnormal_nose_morphology	1.23797791
56	MP0002557_abnormal_social/conspecific_i	1.22218734
57	MP0002572_abnormal_emotion/affect_behav	1.22196664
58	MP0003011_delayed_dark_adaptation	1.21702671
59	MP0003937_abnormal_limbs/digits/tail_de	1.21262941
60	MP0003119_abnormal_digestive_system	1.19823721
61	MP0000569_abnormal_digit_pigmentation	1.17941106
62	MP0003567_abnormal_fetal_cardiomyocyte	1.17065124
63	MP0003136_yellow_coat_color	1.16196931
64	MP0002064_seizures	1.15282417
65	MP0008995_early_reproductive_senescence	1.13669580
66	MP0000566_synostosis	1.13530394
67	MP0002063_abnormal_learning/memory/cond	1.12416473
68	MP0002752_abnormal_somatic_nervous	1.12285121
69	MP0003755_abnormal_palate_morphology	1.11944459
70	MP0010094_abnormal_chromosome_stability	1.11572851
71	MP0001970_abnormal_pain_threshold	1.08531944
72	MP0003938_abnormal_ear_development	1.07440770
73	MP0005386_behavior/neurological_phenoty	1.06985989
74	MP0004924_abnormal_behavior	1.06985989
75	MP0001986_abnormal_taste_sensitivity	1.06714878
76	MP0002067_abnormal_sensory_capabilities	1.05993344
77	MP0000955_abnormal_spinal_cord	1.05891474
78	MP0005195_abnormal_posterior_eye	1.03469731
79	MP0002733_abnormal_thermal_nociception	1.03227361
80	MP0004859_abnormal_synaptic_plasticity	1.02442663
81	MP0002160_abnormal_reproductive_system	1.00552919
82	MP0000647_abnormal_sebaceous_gland	0.98624631
83	MP0001286_abnormal_eye_development	0.93736586
84	MP0002882_abnormal_neuron_morphology	0.93686664
85	MP0003861_abnormal_nervous_system	0.93305573
86	MP0005187_abnormal_penis_morphology	0.93247833
87	MP0002822_catalepsy	0.93044123
88	MP0000026_abnormal_inner_ear	0.91969368
89	MP0004742_abnormal_vestibular_system	0.91666291
90	MP0005391_vision/eye_phenotype	0.90896617
91	MP0002282_abnormal_trachea_morphology	0.90686555
92	MP0002210_abnormal_sex_determination	0.90462263
93	MP0000427_abnormal_hair_cycle	0.90129659
94	MP0003693_abnormal_embryo_hatching	0.89335557
95	MP0003698_abnormal_male_reproductive	0.86852234
96	MP0004145_abnormal_muscle_electrophysio	0.84878602
97	MP0001929_abnormal_gametogenesis	0.84618438
98	MP0002152_abnormal_brain_morphology	0.84096631
99	MP0000653_abnormal_sex_gland	0.80811541
100	MP0004215_abnormal_myocardial_fiber	0.79865798

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.68954372
2	Pancreatic fibrosis (HP:0100732)	3.61401004
3	True hermaphroditism (HP:0010459)	3.46840856
4	Abnormality of the labia minora (HP:0012880)	3.26141843
5	Molar tooth sign on MRI (HP:0002419)	3.24343544
6	Abnormality of midbrain morphology (HP:0002418)	3.24343544
7	Nephronophthisis (HP:0000090)	3.13194520
8	Hyperventilation (HP:0002883)	3.05496868
9	Medial flaring of the eyebrow (HP:0010747)	2.91014233
10	Pendular nystagmus (HP:0012043)	2.83494235
11	Intestinal atresia (HP:0011100)	2.66502110
12	Congenital stationary night blindness (HP:0007642)	2.62987725
13	Abnormality of the renal medulla (HP:0100957)	2.62454257
14	Gait imbalance (HP:0002141)	2.61486781
15	Methylmalonic acidemia (HP:0002912)	2.57285056
16	Broad-based gait (HP:0002136)	2.55673483
17	Type II lissencephaly (HP:0007260)	2.53808783
18	Colon cancer (HP:0003003)	2.49013613
19	Congenital primary aphakia (HP:0007707)	2.46888325
20	Lissencephaly (HP:0001339)	2.45961223
21	Optic nerve hypoplasia (HP:0000609)	2.42682626
22	3-Methylglutaconic aciduria (HP:0003535)	2.36383047
23	Abnormality of the renal cortex (HP:0011035)	2.36317812
24	Nephrogenic diabetes insipidus (HP:0009806)	2.35854358
25	Genital tract atresia (HP:0001827)	2.34452728
26	Sclerocornea (HP:0000647)	2.33341601
27	Abolished electroretinogram (ERG) (HP:0000550)	2.28595077
28	Septo-optic dysplasia (HP:0100842)	2.28325023
29	Chronic hepatic failure (HP:0100626)	2.27767030
30	Vaginal atresia (HP:0000148)	2.25411513
31	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.23956336
32	Volvulus (HP:0002580)	2.22270513
33	Hyperglycinemia (HP:0002154)	2.19311469
34	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.18850662
35	Focal motor seizures (HP:0011153)	2.18084677
36	Acute necrotizing encephalopathy (HP:0006965)	2.15847771
37	Anencephaly (HP:0002323)	2.15547673
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14981071
39	Hypothermia (HP:0002045)	2.13407796
40	Pachygyria (HP:0001302)	2.12988072
41	Cystic liver disease (HP:0006706)	2.09185513
42	Drooling (HP:0002307)	2.08478997
43	Inability to walk (HP:0002540)	2.08450047
44	Patellar aplasia (HP:0006443)	2.07181891
45	Absent speech (HP:0001344)	2.06679836
46	Postaxial hand polydactyly (HP:0001162)	2.06483321
47	Gaze-evoked nystagmus (HP:0000640)	2.06366777
48	Methylmalonic aciduria (HP:0012120)	2.02529861
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.02386224
50	Postaxial foot polydactyly (HP:0001830)	2.02313714
51	Progressive macrocephaly (HP:0004481)	2.01961808
52	Abnormality of the ileum (HP:0001549)	2.01582066
53	Aplasia/Hypoplasia of the patella (HP:0006498)	1.99039084
54	Meckel diverticulum (HP:0002245)	1.98913037
55	Acute encephalopathy (HP:0006846)	1.98127038
56	Dandy-Walker malformation (HP:0001305)	1.97778988
57	Retinal dysplasia (HP:0007973)	1.97313441
58	Progressive inability to walk (HP:0002505)	1.97142417
59	Renal cortical cysts (HP:0000803)	1.95308929
60	Focal seizures (HP:0007359)	1.94017978
61	Mitochondrial inheritance (HP:0001427)	1.93814056
62	Preaxial hand polydactyly (HP:0001177)	1.93098940
63	Small hand (HP:0200055)	1.92242121
64	Oligodactyly (hands) (HP:0001180)	1.89997068
65	Gastrointestinal atresia (HP:0002589)	1.88903549
66	Increased corneal curvature (HP:0100692)	1.85515772
67	Keratoconus (HP:0000563)	1.85515772
68	Renal hypoplasia (HP:0000089)	1.85063527
69	Attenuation of retinal blood vessels (HP:0007843)	1.84499722
70	Increased CSF lactate (HP:0002490)	1.84447450
71	Male pseudohermaphroditism (HP:0000037)	1.83947009
72	Excessive salivation (HP:0003781)	1.83733328
73	Abnormality of chromosome stability (HP:0003220)	1.82050317
74	Thyroid-stimulating hormone excess (HP:0002925)	1.80979241
75	Neoplasm of the adrenal cortex (HP:0100641)	1.80304963
76	Progressive cerebellar ataxia (HP:0002073)	1.79832641
77	Anophthalmia (HP:0000528)	1.77911605
78	Narrow forehead (HP:0000341)	1.77819091
79	Short tibia (HP:0005736)	1.77157287
80	Abnormal mitochondria in muscle tissue (HP:0008316)	1.75802065
81	Growth hormone deficiency (HP:0000824)	1.75392048
82	Abnormal rod and cone electroretinograms (HP:0008323)	1.75037758
83	Chorioretinal atrophy (HP:0000533)	1.74977951
84	Aqueductal stenosis (HP:0002410)	1.74928392
85	Abnormal lung lobation (HP:0002101)	1.73532891
86	Specific learning disability (HP:0001328)	1.71905991
87	Poor coordination (HP:0002370)	1.71210441
88	Glioma (HP:0009733)	1.69368701
89	Bifid tongue (HP:0010297)	1.69267047
90	Astigmatism (HP:0000483)	1.69182967
91	Cerebellar dysplasia (HP:0007033)	1.69128188
92	Astrocytoma (HP:0009592)	1.68327431
93	Abnormality of the astrocytes (HP:0100707)	1.68327431
94	Hepatocellular necrosis (HP:0001404)	1.68059575
95	Congenital hepatic fibrosis (HP:0002612)	1.67804673
96	Limb dystonia (HP:0002451)	1.67603600
97	Sloping forehead (HP:0000340)	1.67076708
98	Bony spicule pigmentary retinopathy (HP:0007737)	1.66587730
99	Aganglionic megacolon (HP:0002251)	1.66473971
100	Ependymoma (HP:0002888)	1.65769851

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.76013840
2	WNK3	3.73424425
3	CASK	3.26332393
4	MARK1	2.76535020
5	MAP4K2	2.55956308
6	TNIK	2.49570152
7	NUAK1	2.42858380
8	TRIM28	2.35971449
9	MAP3K4	2.23514348
10	BMPR1B	2.22758580
11	MAPK13	2.20753835
12	ZAK	2.15752332
13	EPHA4	2.00896479
14	MKNK2	1.89825564
15	MAP2K7	1.87530462
16	ADRBK2	1.87016187
17	DYRK2	1.79045859
18	PINK1	1.71064209
19	GRK1	1.64390454
20	BCR	1.63348053
21	ERBB3	1.57444648
22	ACVR1B	1.45164495
23	MKNK1	1.40575881
24	BUB1	1.38497467
25	SRPK1	1.37443859
26	PLK3	1.37367213
27	PNCK	1.35557212
28	CSNK1G1	1.33189280
29	VRK1	1.31344833
30	PLK4	1.29861015
31	INSRR	1.28973092
32	CSNK1G2	1.20360004
33	STK16	1.18636225
34	CSNK1G3	1.15846585
35	EIF2AK3	1.13770590
36	OXSR1	1.12607856
37	BRSK2	1.11924962
38	PAK3	1.11274562
39	PLK2	1.08070145
40	WEE1	1.07696680
41	TSSK6	1.01822439
42	FGFR2	0.99900076
43	PRKCG	0.99459028
44	CSNK1A1L	0.98940003
45	MINK1	0.93421956
46	DYRK3	0.92644825
47	TLK1	0.89725899
48	CDC7	0.87155002
49	VRK2	0.86848070
50	NTRK3	0.80839678
51	MAP2K4	0.80790739
52	PRKCE	0.80362249
53	STK39	0.78728101
54	PLK1	0.76572747
55	NTRK2	0.76464995
56	STK38L	0.74971301
57	PKN1	0.71040704
58	TAF1	0.66504913
59	WNK4	0.65830721
60	AKT3	0.65160881
61	TGFBR1	0.62401263
62	ATR	0.62304339
63	DAPK2	0.61620189
64	ADRBK1	0.60447387
65	TIE1	0.56801210
66	CAMKK2	0.54655226
67	NLK	0.51519065
68	CSNK1A1	0.50829154
69	EPHB2	0.50719195
70	DYRK1A	0.50414216
71	ATM	0.48812260
72	CDK3	0.47948210
73	SGK2	0.47859205
74	CCNB1	0.46743686
75	CAMK2A	0.45794601
76	STK3	0.45685838
77	BCKDK	0.45418882
78	TTK	0.44192706
79	FLT3	0.43730707
80	NME1	0.43631060
81	EPHA3	0.43435167
82	PHKG2	0.42588044
83	PHKG1	0.42588044
84	CHEK2	0.42197830
85	SIK2	0.40989091
86	UHMK1	0.40648942
87	MST4	0.40412726
88	TAOK3	0.39169916
89	MAP3K12	0.38671164
90	CSNK1D	0.38617649
91	PRKACA	0.38302063
92	CSNK1E	0.36958362
93	MUSK	0.36874237
94	STK11	0.36164454
95	PRKCZ	0.35050437
96	BRSK1	0.34534731
97	RPS6KA4	0.34294358
98	RPS6KA5	0.33889412
99	CDK19	0.33200333
100	EIF2AK2	0.32315224

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.90965028
2	Nicotine addiction_Homo sapiens_hsa05033	2.66048351
3	Phototransduction_Homo sapiens_hsa04744	2.50360105
4	Protein export_Homo sapiens_hsa03060	2.49289085
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33003144
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.31940251
7	Homologous recombination_Homo sapiens_hsa03440	2.23374679
8	Basal transcription factors_Homo sapiens_hsa03022	2.23360009
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.22398866
10	RNA polymerase_Homo sapiens_hsa03020	2.16579836
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.14275252
12	Parkinsons disease_Homo sapiens_hsa05012	2.01788442
13	Butanoate metabolism_Homo sapiens_hsa00650	2.01324812
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98641703
15	Proteasome_Homo sapiens_hsa03050	1.88538763
16	Propanoate metabolism_Homo sapiens_hsa00640	1.83935684
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.83285949
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.76693401
19	RNA degradation_Homo sapiens_hsa03018	1.70880899
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.66811279
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62981490
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.62171622
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59446332
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.57308501
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.48386875
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.46753097
27	Taste transduction_Homo sapiens_hsa04742	1.44030935
28	Huntingtons disease_Homo sapiens_hsa05016	1.43384176
29	Mismatch repair_Homo sapiens_hsa03430	1.41858387
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.35093002
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.34879177
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29407304
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15293798
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13750720
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.12335620
36	Alzheimers disease_Homo sapiens_hsa05010	1.11597556
37	Morphine addiction_Homo sapiens_hsa05032	1.09702578
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.09504601
39	GABAergic synapse_Homo sapiens_hsa04727	1.08649230
40	RNA transport_Homo sapiens_hsa03013	1.07806453
41	Caffeine metabolism_Homo sapiens_hsa00232	1.04717291
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01058694
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.00742621
44	Peroxisome_Homo sapiens_hsa04146	0.98767158
45	Olfactory transduction_Homo sapiens_hsa04740	0.98424043
46	Base excision repair_Homo sapiens_hsa03410	0.98138399
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96878613
48	Circadian entrainment_Homo sapiens_hsa04713	0.95506210
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95139910
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.94863479
51	Fatty acid elongation_Homo sapiens_hsa00062	0.93276558
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.93107322
53	Spliceosome_Homo sapiens_hsa03040	0.92385691
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91052351
55	Regulation of autophagy_Homo sapiens_hsa04140	0.90101811
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.87874545
57	Purine metabolism_Homo sapiens_hsa00230	0.87793645
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.86817307
59	Basal cell carcinoma_Homo sapiens_hsa05217	0.84162521
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.82994216
61	DNA replication_Homo sapiens_hsa03030	0.82610143
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80091873
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79833673
64	Retinol metabolism_Homo sapiens_hsa00830	0.77993948
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76030436
66	One carbon pool by folate_Homo sapiens_hsa00670	0.75825479
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75657554
68	Serotonergic synapse_Homo sapiens_hsa04726	0.75226566
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74564097
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73676528
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71549475
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70663384
73	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70630252
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.69450536
75	Oocyte meiosis_Homo sapiens_hsa04114	0.66886178
76	Axon guidance_Homo sapiens_hsa04360	0.66028498
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65669060
78	Insulin secretion_Homo sapiens_hsa04911	0.62499296
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62291079
80	Metabolic pathways_Homo sapiens_hsa01100	0.62021018
81	Amphetamine addiction_Homo sapiens_hsa05031	0.61737923
82	Cell cycle_Homo sapiens_hsa04110	0.59738206
83	Cocaine addiction_Homo sapiens_hsa05030	0.59733498
84	Long-term depression_Homo sapiens_hsa04730	0.56856522
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55109817
86	Fatty acid degradation_Homo sapiens_hsa00071	0.54304377
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54058911
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52694401
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51912263
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.51346800
91	Sulfur metabolism_Homo sapiens_hsa00920	0.51251570
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.49195380
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.46538466
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.44291688
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.43978720
96	Wnt signaling pathway_Homo sapiens_hsa04310	0.43899127
97	Salivary secretion_Homo sapiens_hsa04970	0.41574290
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40689086
99	p53 signaling pathway_Homo sapiens_hsa04115	0.38845260
100	Lysine degradation_Homo sapiens_hsa00310	0.38162377

ZNF286B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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