ZNF286B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.44807457
2DNA double-strand break processing (GO:0000729)4.20194761
3limb bud formation (GO:0060174)4.07386179
4presynaptic membrane assembly (GO:0097105)4.06853140
5behavioral response to nicotine (GO:0035095)3.97549878
6presynaptic membrane organization (GO:0097090)3.93126549
7neural tube formation (GO:0001841)3.83540915
8nucleobase catabolic process (GO:0046113)3.60908560
9somite development (GO:0061053)3.50220990
10replication fork processing (GO:0031297)3.46199248
11negative regulation of transcription regulatory region DNA binding (GO:2000678)3.18031255
12neuron cell-cell adhesion (GO:0007158)3.17952088
13protein neddylation (GO:0045116)3.14087192
14DNA damage response, detection of DNA damage (GO:0042769)3.05820900
15cornea development in camera-type eye (GO:0061303)3.05265817
16protein complex biogenesis (GO:0070271)3.00604128
17response to pheromone (GO:0019236)2.95667316
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95264756
19regulation of mitotic spindle checkpoint (GO:1903504)2.95264756
20regulation of nuclear cell cycle DNA replication (GO:0033262)2.94755300
21regulation of telomere maintenance (GO:0032204)2.94137578
22negative regulation of telomere maintenance (GO:0032205)2.93957178
23mitochondrial respiratory chain complex I assembly (GO:0032981)2.92898034
24NADH dehydrogenase complex assembly (GO:0010257)2.92898034
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92898034
26kidney morphogenesis (GO:0060993)2.91245282
27sympathetic nervous system development (GO:0048485)2.88116597
28gamma-aminobutyric acid transport (GO:0015812)2.87190188
29protein polyglutamylation (GO:0018095)2.85863357
30spinal cord development (GO:0021510)2.85832409
31intraciliary transport (GO:0042073)2.84568519
32water-soluble vitamin biosynthetic process (GO:0042364)2.84556459
33transmission of nerve impulse (GO:0019226)2.82241475
34retinal ganglion cell axon guidance (GO:0031290)2.81720188
35establishment of protein localization to mitochondrial membrane (GO:0090151)2.81002583
36platelet dense granule organization (GO:0060155)2.80669553
37protein-cofactor linkage (GO:0018065)2.80122300
38negative regulation of DNA-dependent DNA replication (GO:2000104)2.79826634
39postsynaptic membrane organization (GO:0001941)2.79414006
40mitochondrial respiratory chain complex assembly (GO:0033108)2.79035518
41cell proliferation in forebrain (GO:0021846)2.75897945
42respiratory chain complex IV assembly (GO:0008535)2.74359899
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72832649
44nonmotile primary cilium assembly (GO:0035058)2.72568645
45centriole replication (GO:0007099)2.72277849
46fucose catabolic process (GO:0019317)2.70639803
47L-fucose metabolic process (GO:0042354)2.70639803
48L-fucose catabolic process (GO:0042355)2.70639803
49epithelial cilium movement (GO:0003351)2.69018490
50regulation of timing of cell differentiation (GO:0048505)2.68867937
51negative regulation of translation, ncRNA-mediated (GO:0040033)2.68416992
52regulation of translation, ncRNA-mediated (GO:0045974)2.68416992
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68416992
54indolalkylamine metabolic process (GO:0006586)2.67887797
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67548842
56regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.66078921
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65493637
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65167795
59resolution of meiotic recombination intermediates (GO:0000712)2.62345547
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61433538
61indole-containing compound catabolic process (GO:0042436)2.61367347
62indolalkylamine catabolic process (GO:0046218)2.61367347
63tryptophan catabolic process (GO:0006569)2.61367347
64histone H2A acetylation (GO:0043968)2.61054552
65olfactory bulb development (GO:0021772)2.60559575
66DNA deamination (GO:0045006)2.58831970
67vocalization behavior (GO:0071625)2.56397341
68regulation of meiosis I (GO:0060631)2.55854772
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55292066
70kynurenine metabolic process (GO:0070189)2.53637882
71cullin deneddylation (GO:0010388)2.53284186
72chromatin remodeling at centromere (GO:0031055)2.53125220
73recombinational repair (GO:0000725)2.52175713
74behavioral response to ethanol (GO:0048149)2.50600598
75cytochrome complex assembly (GO:0017004)2.49571381
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.49514382
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49514382
78double-strand break repair via homologous recombination (GO:0000724)2.49385641
79regulation of development, heterochronic (GO:0040034)2.49329605
80regulation of cilium movement (GO:0003352)2.48705287
81cilium morphogenesis (GO:0060271)2.48135264
82cerebral cortex radially oriented cell migration (GO:0021799)2.46244930
83axonal fasciculation (GO:0007413)2.46195525
84tryptophan metabolic process (GO:0006568)2.45187640
85neuron recognition (GO:0008038)2.44571870
86regulation of collateral sprouting (GO:0048670)2.42023007
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.38815543
88glial cell proliferation (GO:0014009)2.38423313
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.38120000
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.38120000
91retinal cone cell development (GO:0046549)2.37754682
92protein localization to cilium (GO:0061512)2.37324398
93central nervous system projection neuron axonogenesis (GO:0021952)2.36453651
94dendritic spine morphogenesis (GO:0060997)2.36438713
95anterograde synaptic vesicle transport (GO:0048490)2.36251269
96photoreceptor cell development (GO:0042461)2.34059452
97cilium organization (GO:0044782)2.33952282
98sulfation (GO:0051923)2.33218813
99positive regulation of mitochondrial fission (GO:0090141)2.33104235
100DNA catabolic process, exonucleolytic (GO:0000738)2.32623148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.57961361
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.21040947
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88567259
4GBX2_23144817_ChIP-Seq_PC3_Human2.84609173
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75214177
6VDR_22108803_ChIP-Seq_LS180_Human2.68678798
7EZH2_22144423_ChIP-Seq_EOC_Human2.54405475
8IGF1R_20145208_ChIP-Seq_DFB_Human2.52276702
9FUS_26573619_Chip-Seq_HEK293_Human2.48389847
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47981536
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47134888
12EWS_26573619_Chip-Seq_HEK293_Human2.45442638
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27320058
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26829473
15TAF15_26573619_Chip-Seq_HEK293_Human2.23631100
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20221471
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19733159
18P300_19829295_ChIP-Seq_ESCs_Human2.17676908
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12994743
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08198939
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.06967541
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99806894
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.99439508
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96630608
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95420357
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.81551281
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.75481174
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73766397
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70496374
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63392306
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59245619
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56823186
33ELK1_19687146_ChIP-ChIP_HELA_Human1.56375873
34ER_23166858_ChIP-Seq_MCF-7_Human1.55521315
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53772308
36RNF2_27304074_Chip-Seq_NSC_Mouse1.52651281
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52226730
38SMAD4_21799915_ChIP-Seq_A2780_Human1.49475970
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49268504
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49160760
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.47129359
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46911809
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46115911
44MYC_18940864_ChIP-ChIP_HL60_Human1.45143562
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43426973
46CBP_20019798_ChIP-Seq_JUKART_Human1.42838421
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42838421
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42221344
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.39949869
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39069051
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39069051
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38651177
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.38348639
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37889662
55AR_25329375_ChIP-Seq_VCAP_Human1.36705396
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36206008
57IRF1_19129219_ChIP-ChIP_H3396_Human1.35561213
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31353880
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29033942
60REST_21632747_ChIP-Seq_MESCs_Mouse1.28145135
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27778045
62BCAT_22108803_ChIP-Seq_LS180_Human1.26837438
63STAT3_23295773_ChIP-Seq_U87_Human1.25989478
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.25634037
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23081928
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22728620
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21306742
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20529834
69TCF4_23295773_ChIP-Seq_U87_Human1.20265614
70TP53_22573176_ChIP-Seq_HFKS_Human1.19625205
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.18626229
72TCF4_22108803_ChIP-Seq_LS180_Human1.18190766
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17826932
74VDR_23849224_ChIP-Seq_CD4+_Human1.14851898
75RUNX2_22187159_ChIP-Seq_PCA_Human1.14204245
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.13855942
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.12242146
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12120973
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11349086
80NANOG_19829295_ChIP-Seq_ESCs_Human1.08606268
81SOX2_19829295_ChIP-Seq_ESCs_Human1.08606268
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.07958785
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07334230
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05912790
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03835729
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.02360605
87P53_22387025_ChIP-Seq_ESCs_Mouse1.02258217
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.00842894
89SMAD4_21741376_ChIP-Seq_EPCs_Human0.98472747
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98296949
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.97441809
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97341225
93JUN_21703547_ChIP-Seq_K562_Human0.96951441
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.95909618
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95692167
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95150182
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94856819
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94304852
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.93580688
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92730489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.56453641
2MP0006292_abnormal_olfactory_placode2.92595825
3MP0002102_abnormal_ear_morphology2.86404322
4MP0008877_abnormal_DNA_methylation2.68764302
5MP0003787_abnormal_imprinting2.41372494
6MP0002736_abnormal_nociception_after2.19326947
7MP0008058_abnormal_DNA_repair2.05665693
8MP0001968_abnormal_touch/_nociception2.01222449
9MP0000778_abnormal_nervous_system1.97665163
10MP0006072_abnormal_retinal_apoptosis1.90585163
11MP0005551_abnormal_eye_electrophysiolog1.89235048
12MP0002751_abnormal_autonomic_nervous1.86712520
13MP0001529_abnormal_vocalization1.82144645
14MP0003121_genomic_imprinting1.80502092
15MP0000631_abnormal_neuroendocrine_gland1.80342055
16MP0008789_abnormal_olfactory_epithelium1.79797607
17MP0006276_abnormal_autonomic_nervous1.75513791
18MP0002938_white_spotting1.71498628
19MP0002234_abnormal_pharynx_morphology1.64074056
20MP0005646_abnormal_pituitary_gland1.63098461
21MP0001188_hyperpigmentation1.62752708
22MP0004885_abnormal_endolymph1.62276965
23MP0009745_abnormal_behavioral_response1.61441690
24MP0003122_maternal_imprinting1.59554315
25MP0005253_abnormal_eye_physiology1.59015330
26MP0009046_muscle_twitch1.58073495
27MP0002272_abnormal_nervous_system1.57056955
28MP0004133_heterotaxia1.56931184
29MP0001984_abnormal_olfaction1.55868201
30MP0003195_calcinosis1.55238477
31MP0001486_abnormal_startle_reflex1.54363259
32MP0005367_renal/urinary_system_phenotyp1.54012970
33MP0000516_abnormal_urinary_system1.54012970
34MP0000049_abnormal_middle_ear1.52278082
35MP0003890_abnormal_embryonic-extraembry1.49032123
36MP0001485_abnormal_pinna_reflex1.47858017
37MP0002735_abnormal_chemical_nociception1.43581874
38MP0008872_abnormal_physiological_respon1.43412541
39MP0000372_irregular_coat_pigmentation1.42353294
40MP0005394_taste/olfaction_phenotype1.41528404
41MP0005499_abnormal_olfactory_system1.41528404
42MP0002837_dystrophic_cardiac_calcinosis1.40254895
43MP0003718_maternal_effect1.38100500
44MP0001293_anophthalmia1.34103412
45MP0002653_abnormal_ependyma_morphology1.32846876
46MP0002638_abnormal_pupillary_reflex1.32247808
47MP0003635_abnormal_synaptic_transmissio1.29568076
48MP0002184_abnormal_innervation1.29517939
49MP0002734_abnormal_mechanical_nocicepti1.25714439
50MP0004142_abnormal_muscle_tone1.25447236
51MP0005423_abnormal_somatic_nervous1.24960469
52MP0005084_abnormal_gallbladder_morpholo1.24231755
53MP0005645_abnormal_hypothalamus_physiol1.24176531
54MP0004270_analgesia1.24054521
55MP0002233_abnormal_nose_morphology1.23797791
56MP0002557_abnormal_social/conspecific_i1.22218734
57MP0002572_abnormal_emotion/affect_behav1.22196664
58MP0003011_delayed_dark_adaptation1.21702671
59MP0003937_abnormal_limbs/digits/tail_de1.21262941
60MP0003119_abnormal_digestive_system1.19823721
61MP0000569_abnormal_digit_pigmentation1.17941106
62MP0003567_abnormal_fetal_cardiomyocyte1.17065124
63MP0003136_yellow_coat_color1.16196931
64MP0002064_seizures1.15282417
65MP0008995_early_reproductive_senescence1.13669580
66MP0000566_synostosis1.13530394
67MP0002063_abnormal_learning/memory/cond1.12416473
68MP0002752_abnormal_somatic_nervous1.12285121
69MP0003755_abnormal_palate_morphology1.11944459
70MP0010094_abnormal_chromosome_stability1.11572851
71MP0001970_abnormal_pain_threshold1.08531944
72MP0003938_abnormal_ear_development1.07440770
73MP0005386_behavior/neurological_phenoty1.06985989
74MP0004924_abnormal_behavior1.06985989
75MP0001986_abnormal_taste_sensitivity1.06714878
76MP0002067_abnormal_sensory_capabilities1.05993344
77MP0000955_abnormal_spinal_cord1.05891474
78MP0005195_abnormal_posterior_eye1.03469731
79MP0002733_abnormal_thermal_nociception1.03227361
80MP0004859_abnormal_synaptic_plasticity1.02442663
81MP0002160_abnormal_reproductive_system1.00552919
82MP0000647_abnormal_sebaceous_gland0.98624631
83MP0001286_abnormal_eye_development0.93736586
84MP0002882_abnormal_neuron_morphology0.93686664
85MP0003861_abnormal_nervous_system0.93305573
86MP0005187_abnormal_penis_morphology0.93247833
87MP0002822_catalepsy0.93044123
88MP0000026_abnormal_inner_ear0.91969368
89MP0004742_abnormal_vestibular_system0.91666291
90MP0005391_vision/eye_phenotype0.90896617
91MP0002282_abnormal_trachea_morphology0.90686555
92MP0002210_abnormal_sex_determination0.90462263
93MP0000427_abnormal_hair_cycle0.90129659
94MP0003693_abnormal_embryo_hatching0.89335557
95MP0003698_abnormal_male_reproductive0.86852234
96MP0004145_abnormal_muscle_electrophysio0.84878602
97MP0001929_abnormal_gametogenesis0.84618438
98MP0002152_abnormal_brain_morphology0.84096631
99MP0000653_abnormal_sex_gland0.80811541
100MP0004215_abnormal_myocardial_fiber0.79865798

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.68954372
2Pancreatic fibrosis (HP:0100732)3.61401004
3True hermaphroditism (HP:0010459)3.46840856
4Abnormality of the labia minora (HP:0012880)3.26141843
5Molar tooth sign on MRI (HP:0002419)3.24343544
6Abnormality of midbrain morphology (HP:0002418)3.24343544
7Nephronophthisis (HP:0000090)3.13194520
8Hyperventilation (HP:0002883)3.05496868
9Medial flaring of the eyebrow (HP:0010747)2.91014233
10Pendular nystagmus (HP:0012043)2.83494235
11Intestinal atresia (HP:0011100)2.66502110
12Congenital stationary night blindness (HP:0007642)2.62987725
13Abnormality of the renal medulla (HP:0100957)2.62454257
14Gait imbalance (HP:0002141)2.61486781
15Methylmalonic acidemia (HP:0002912)2.57285056
16Broad-based gait (HP:0002136)2.55673483
17Type II lissencephaly (HP:0007260)2.53808783
18Colon cancer (HP:0003003)2.49013613
19Congenital primary aphakia (HP:0007707)2.46888325
20Lissencephaly (HP:0001339)2.45961223
21Optic nerve hypoplasia (HP:0000609)2.42682626
223-Methylglutaconic aciduria (HP:0003535)2.36383047
23Abnormality of the renal cortex (HP:0011035)2.36317812
24Nephrogenic diabetes insipidus (HP:0009806)2.35854358
25Genital tract atresia (HP:0001827)2.34452728
26Sclerocornea (HP:0000647)2.33341601
27Abolished electroretinogram (ERG) (HP:0000550)2.28595077
28Septo-optic dysplasia (HP:0100842)2.28325023
29Chronic hepatic failure (HP:0100626)2.27767030
30Vaginal atresia (HP:0000148)2.25411513
31Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23956336
32Volvulus (HP:0002580)2.22270513
33Hyperglycinemia (HP:0002154)2.19311469
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.18850662
35Focal motor seizures (HP:0011153)2.18084677
36Acute necrotizing encephalopathy (HP:0006965)2.15847771
37Anencephaly (HP:0002323)2.15547673
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.14981071
39Hypothermia (HP:0002045)2.13407796
40Pachygyria (HP:0001302)2.12988072
41Cystic liver disease (HP:0006706)2.09185513
42Drooling (HP:0002307)2.08478997
43Inability to walk (HP:0002540)2.08450047
44Patellar aplasia (HP:0006443)2.07181891
45Absent speech (HP:0001344)2.06679836
46Postaxial hand polydactyly (HP:0001162)2.06483321
47Gaze-evoked nystagmus (HP:0000640)2.06366777
48Methylmalonic aciduria (HP:0012120)2.02529861
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.02386224
50Postaxial foot polydactyly (HP:0001830)2.02313714
51Progressive macrocephaly (HP:0004481)2.01961808
52Abnormality of the ileum (HP:0001549)2.01582066
53Aplasia/Hypoplasia of the patella (HP:0006498)1.99039084
54Meckel diverticulum (HP:0002245)1.98913037
55Acute encephalopathy (HP:0006846)1.98127038
56Dandy-Walker malformation (HP:0001305)1.97778988
57Retinal dysplasia (HP:0007973)1.97313441
58Progressive inability to walk (HP:0002505)1.97142417
59Renal cortical cysts (HP:0000803)1.95308929
60Focal seizures (HP:0007359)1.94017978
61Mitochondrial inheritance (HP:0001427)1.93814056
62Preaxial hand polydactyly (HP:0001177)1.93098940
63Small hand (HP:0200055)1.92242121
64Oligodactyly (hands) (HP:0001180)1.89997068
65Gastrointestinal atresia (HP:0002589)1.88903549
66Increased corneal curvature (HP:0100692)1.85515772
67Keratoconus (HP:0000563)1.85515772
68Renal hypoplasia (HP:0000089)1.85063527
69Attenuation of retinal blood vessels (HP:0007843)1.84499722
70Increased CSF lactate (HP:0002490)1.84447450
71Male pseudohermaphroditism (HP:0000037)1.83947009
72Excessive salivation (HP:0003781)1.83733328
73Abnormality of chromosome stability (HP:0003220)1.82050317
74Thyroid-stimulating hormone excess (HP:0002925)1.80979241
75Neoplasm of the adrenal cortex (HP:0100641)1.80304963
76Progressive cerebellar ataxia (HP:0002073)1.79832641
77Anophthalmia (HP:0000528)1.77911605
78Narrow forehead (HP:0000341)1.77819091
79Short tibia (HP:0005736)1.77157287
80Abnormal mitochondria in muscle tissue (HP:0008316)1.75802065
81Growth hormone deficiency (HP:0000824)1.75392048
82Abnormal rod and cone electroretinograms (HP:0008323)1.75037758
83Chorioretinal atrophy (HP:0000533)1.74977951
84Aqueductal stenosis (HP:0002410)1.74928392
85Abnormal lung lobation (HP:0002101)1.73532891
86Specific learning disability (HP:0001328)1.71905991
87Poor coordination (HP:0002370)1.71210441
88Glioma (HP:0009733)1.69368701
89Bifid tongue (HP:0010297)1.69267047
90Astigmatism (HP:0000483)1.69182967
91Cerebellar dysplasia (HP:0007033)1.69128188
92Astrocytoma (HP:0009592)1.68327431
93Abnormality of the astrocytes (HP:0100707)1.68327431
94Hepatocellular necrosis (HP:0001404)1.68059575
95Congenital hepatic fibrosis (HP:0002612)1.67804673
96Limb dystonia (HP:0002451)1.67603600
97Sloping forehead (HP:0000340)1.67076708
98Bony spicule pigmentary retinopathy (HP:0007737)1.66587730
99Aganglionic megacolon (HP:0002251)1.66473971
100Ependymoma (HP:0002888)1.65769851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.76013840
2WNK33.73424425
3CASK3.26332393
4MARK12.76535020
5MAP4K22.55956308
6TNIK2.49570152
7NUAK12.42858380
8TRIM282.35971449
9MAP3K42.23514348
10BMPR1B2.22758580
11MAPK132.20753835
12ZAK2.15752332
13EPHA42.00896479
14MKNK21.89825564
15MAP2K71.87530462
16ADRBK21.87016187
17DYRK21.79045859
18PINK11.71064209
19GRK11.64390454
20BCR1.63348053
21ERBB31.57444648
22ACVR1B1.45164495
23MKNK11.40575881
24BUB11.38497467
25SRPK11.37443859
26PLK31.37367213
27PNCK1.35557212
28CSNK1G11.33189280
29VRK11.31344833
30PLK41.29861015
31INSRR1.28973092
32CSNK1G21.20360004
33STK161.18636225
34CSNK1G31.15846585
35EIF2AK31.13770590
36OXSR11.12607856
37BRSK21.11924962
38PAK31.11274562
39PLK21.08070145
40WEE11.07696680
41TSSK61.01822439
42FGFR20.99900076
43PRKCG0.99459028
44CSNK1A1L0.98940003
45MINK10.93421956
46DYRK30.92644825
47TLK10.89725899
48CDC70.87155002
49VRK20.86848070
50NTRK30.80839678
51MAP2K40.80790739
52PRKCE0.80362249
53STK390.78728101
54PLK10.76572747
55NTRK20.76464995
56STK38L0.74971301
57PKN10.71040704
58TAF10.66504913
59WNK40.65830721
60AKT30.65160881
61TGFBR10.62401263
62ATR0.62304339
63DAPK20.61620189
64ADRBK10.60447387
65TIE10.56801210
66CAMKK20.54655226
67NLK0.51519065
68CSNK1A10.50829154
69EPHB20.50719195
70DYRK1A0.50414216
71ATM0.48812260
72CDK30.47948210
73SGK20.47859205
74CCNB10.46743686
75CAMK2A0.45794601
76STK30.45685838
77BCKDK0.45418882
78TTK0.44192706
79FLT30.43730707
80NME10.43631060
81EPHA30.43435167
82PHKG20.42588044
83PHKG10.42588044
84CHEK20.42197830
85SIK20.40989091
86UHMK10.40648942
87MST40.40412726
88TAOK30.39169916
89MAP3K120.38671164
90CSNK1D0.38617649
91PRKACA0.38302063
92CSNK1E0.36958362
93MUSK0.36874237
94STK110.36164454
95PRKCZ0.35050437
96BRSK10.34534731
97RPS6KA40.34294358
98RPS6KA50.33889412
99CDK190.33200333
100EIF2AK20.32315224

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90965028
2Nicotine addiction_Homo sapiens_hsa050332.66048351
3Phototransduction_Homo sapiens_hsa047442.50360105
4Protein export_Homo sapiens_hsa030602.49289085
5Oxidative phosphorylation_Homo sapiens_hsa001902.33003144
6Fanconi anemia pathway_Homo sapiens_hsa034602.31940251
7Homologous recombination_Homo sapiens_hsa034402.23374679
8Basal transcription factors_Homo sapiens_hsa030222.23360009
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22398866
10RNA polymerase_Homo sapiens_hsa030202.16579836
11Non-homologous end-joining_Homo sapiens_hsa034502.14275252
12Parkinsons disease_Homo sapiens_hsa050122.01788442
13Butanoate metabolism_Homo sapiens_hsa006502.01324812
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98641703
15Proteasome_Homo sapiens_hsa030501.88538763
16Propanoate metabolism_Homo sapiens_hsa006401.83935684
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83285949
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76693401
19RNA degradation_Homo sapiens_hsa030181.70880899
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66811279
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62981490
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62171622
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59446332
24Selenocompound metabolism_Homo sapiens_hsa004501.57308501
25Steroid biosynthesis_Homo sapiens_hsa001001.48386875
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.46753097
27Taste transduction_Homo sapiens_hsa047421.44030935
28Huntingtons disease_Homo sapiens_hsa050161.43384176
29Mismatch repair_Homo sapiens_hsa034301.41858387
30Nitrogen metabolism_Homo sapiens_hsa009101.35093002
31Tryptophan metabolism_Homo sapiens_hsa003801.34879177
32Linoleic acid metabolism_Homo sapiens_hsa005911.29407304
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15293798
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13750720
35Ether lipid metabolism_Homo sapiens_hsa005651.12335620
36Alzheimers disease_Homo sapiens_hsa050101.11597556
37Morphine addiction_Homo sapiens_hsa050321.09702578
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09504601
39GABAergic synapse_Homo sapiens_hsa047271.08649230
40RNA transport_Homo sapiens_hsa030131.07806453
41Caffeine metabolism_Homo sapiens_hsa002321.04717291
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01058694
43Cardiac muscle contraction_Homo sapiens_hsa042601.00742621
44Peroxisome_Homo sapiens_hsa041460.98767158
45Olfactory transduction_Homo sapiens_hsa047400.98424043
46Base excision repair_Homo sapiens_hsa034100.98138399
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96878613
48Circadian entrainment_Homo sapiens_hsa047130.95506210
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95139910
50Hedgehog signaling pathway_Homo sapiens_hsa043400.94863479
51Fatty acid elongation_Homo sapiens_hsa000620.93276558
52Glutamatergic synapse_Homo sapiens_hsa047240.93107322
53Spliceosome_Homo sapiens_hsa030400.92385691
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91052351
55Regulation of autophagy_Homo sapiens_hsa041400.90101811
56Dopaminergic synapse_Homo sapiens_hsa047280.87874545
57Purine metabolism_Homo sapiens_hsa002300.87793645
58Nucleotide excision repair_Homo sapiens_hsa034200.86817307
59Basal cell carcinoma_Homo sapiens_hsa052170.84162521
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82994216
61DNA replication_Homo sapiens_hsa030300.82610143
62Chemical carcinogenesis_Homo sapiens_hsa052040.80091873
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79833673
64Retinol metabolism_Homo sapiens_hsa008300.77993948
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.76030436
66One carbon pool by folate_Homo sapiens_hsa006700.75825479
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75657554
68Serotonergic synapse_Homo sapiens_hsa047260.75226566
69Pyrimidine metabolism_Homo sapiens_hsa002400.74564097
70Collecting duct acid secretion_Homo sapiens_hsa049660.73676528
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.71549475
72beta-Alanine metabolism_Homo sapiens_hsa004100.70663384
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70630252
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69450536
75Oocyte meiosis_Homo sapiens_hsa041140.66886178
76Axon guidance_Homo sapiens_hsa043600.66028498
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.65669060
78Insulin secretion_Homo sapiens_hsa049110.62499296
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62291079
80Metabolic pathways_Homo sapiens_hsa011000.62021018
81Amphetamine addiction_Homo sapiens_hsa050310.61737923
82Cell cycle_Homo sapiens_hsa041100.59738206
83Cocaine addiction_Homo sapiens_hsa050300.59733498
84Long-term depression_Homo sapiens_hsa047300.56856522
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55109817
86Fatty acid degradation_Homo sapiens_hsa000710.54304377
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54058911
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52694401
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51912263
90Pyruvate metabolism_Homo sapiens_hsa006200.51346800
91Sulfur metabolism_Homo sapiens_hsa009200.51251570
92Hippo signaling pathway_Homo sapiens_hsa043900.49195380
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46538466
94Fatty acid metabolism_Homo sapiens_hsa012120.44291688
95Fat digestion and absorption_Homo sapiens_hsa049750.43978720
96Wnt signaling pathway_Homo sapiens_hsa043100.43899127
97Salivary secretion_Homo sapiens_hsa049700.41574290
98mRNA surveillance pathway_Homo sapiens_hsa030150.40689086
99p53 signaling pathway_Homo sapiens_hsa041150.38845260
100Lysine degradation_Homo sapiens_hsa003100.38162377

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