ZNF287

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)5.84422622
2sodium ion homeostasis (GO:0055078)5.29958936
3protein neddylation (GO:0045116)4.93004435
4ATP synthesis coupled proton transport (GO:0015986)4.66473710
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66473710
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.55915202
7pyrimidine nucleobase catabolic process (GO:0006208)4.52266829
8toxin metabolic process (GO:0009404)4.48644919
9sensory perception of taste (GO:0050909)4.31197320
10protein polyglutamylation (GO:0018095)4.10667128
11protein localization to cilium (GO:0061512)3.98657527
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84721647
13spermatid nucleus differentiation (GO:0007289)3.54258444
14positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.53208126
15presynaptic membrane assembly (GO:0097105)3.51108088
16regulation of telomere maintenance (GO:0032204)3.50095764
17regulation of glycogen (starch) synthase activity (GO:2000465)3.49148078
18alkaloid metabolic process (GO:0009820)3.44494984
19nucleobase catabolic process (GO:0046113)3.44177433
20behavioral response to nicotine (GO:0035095)3.31735861
21electron transport chain (GO:0022900)3.31565308
22respiratory electron transport chain (GO:0022904)3.30056490
23DNA double-strand break processing (GO:0000729)3.25444068
24regulation of collateral sprouting (GO:0048670)3.21788013
25proteasome assembly (GO:0043248)3.19717021
26neurofilament cytoskeleton organization (GO:0060052)3.18986081
27growth hormone secretion (GO:0030252)3.18415318
28snRNA transcription (GO:0009301)3.15894177
29presynaptic membrane organization (GO:0097090)3.15277463
30neural tube formation (GO:0001841)3.13840300
31respiratory chain complex IV assembly (GO:0008535)3.13274797
32auditory receptor cell stereocilium organization (GO:0060088)3.10608325
33pyrimidine dimer repair (GO:0006290)3.08143315
34nucleoside diphosphate catabolic process (GO:0009134)3.07562567
35mannosylation (GO:0097502)3.06608406
36centriole replication (GO:0007099)3.04570475
37activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.01732905
38negative regulation of telomere maintenance (GO:0032205)2.99397444
39establishment of nucleus localization (GO:0040023)2.97335465
40response to histamine (GO:0034776)2.91594278
41hydrogen ion transmembrane transport (GO:1902600)2.89074905
42protein localization to synapse (GO:0035418)2.81986515
43dopamine biosynthetic process (GO:0042416)2.81275108
44proton transport (GO:0015992)2.80699051
45epithelial cilium movement (GO:0003351)2.79190842
46platelet dense granule organization (GO:0060155)2.79051051
47ATP biosynthetic process (GO:0006754)2.78933246
48epithelial cell maturation (GO:0002070)2.78752480
49hydrogen transport (GO:0006818)2.77789829
50cell wall macromolecule catabolic process (GO:0016998)2.75594371
51urinary tract smooth muscle contraction (GO:0014848)2.73170219
52regulation of hexokinase activity (GO:1903299)2.73120399
53regulation of glucokinase activity (GO:0033131)2.73120399
54inner ear receptor stereocilium organization (GO:0060122)2.72934073
55regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.72354893
56synaptic transmission, dopaminergic (GO:0001963)2.69004527
57calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67365631
58protein-cofactor linkage (GO:0018065)2.66072896
59cilium morphogenesis (GO:0060271)2.65769220
60intraciliary transport (GO:0042073)2.65390043
61glycerol ether metabolic process (GO:0006662)2.65311047
62positive regulation of mitochondrial fission (GO:0090141)2.65236596
63positive regulation of protein depolymerization (GO:1901881)2.64806204
64ubiquinone metabolic process (GO:0006743)2.63927214
65dorsal/ventral neural tube patterning (GO:0021904)2.63010218
66behavioral response to ethanol (GO:0048149)2.61094527
67positive regulation of lamellipodium assembly (GO:0010592)2.60876405
68regulation of synapse structural plasticity (GO:0051823)2.60042660
69neuron cell-cell adhesion (GO:0007158)2.59972473
70cAMP catabolic process (GO:0006198)2.59310811
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58966474
72heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.58888836
73ether metabolic process (GO:0018904)2.58555451
74ribonucleoprotein complex disassembly (GO:0032988)2.58165278
75multicellular organismal water homeostasis (GO:0050891)2.58095904
76neurotransmitter-gated ion channel clustering (GO:0072578)2.57840331
77negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56598291
78nonmotile primary cilium assembly (GO:0035058)2.56100256
79purine nucleoside triphosphate biosynthetic process (GO:0009145)2.55224355
80regulation of acyl-CoA biosynthetic process (GO:0050812)2.54992449
81positive regulation of prostaglandin secretion (GO:0032308)2.54540754
82spliceosomal complex assembly (GO:0000245)2.52123129
83photoreceptor cell maintenance (GO:0045494)2.51471991
84cell wall macromolecule metabolic process (GO:0044036)2.49675372
85positive regulation of vesicle fusion (GO:0031340)2.47809800
86synapse assembly (GO:0007416)2.47107658
87positive regulation of protein complex disassembly (GO:0043243)2.47009712
88positive regulation of icosanoid secretion (GO:0032305)2.46646779
89positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.46515741
90regulation of centriole replication (GO:0046599)2.46129389
91regulation of voltage-gated calcium channel activity (GO:1901385)2.45254710
92postsynaptic membrane organization (GO:0001941)2.45019770
93protein transmembrane transport (GO:0071806)2.44486245
94pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.43482677
95metallo-sulfur cluster assembly (GO:0031163)2.43197857
96iron-sulfur cluster assembly (GO:0016226)2.43197857
97retinal ganglion cell axon guidance (GO:0031290)2.43059432
98ubiquinone biosynthetic process (GO:0006744)2.41942593
99cytochrome complex assembly (GO:0017004)2.41314141
100mitochondrial respiratory chain complex assembly (GO:0033108)2.40950278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.64648084
2TAF15_26573619_Chip-Seq_HEK293_Human3.47072597
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.23887400
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88376388
5GBX2_23144817_ChIP-Seq_PC3_Human2.81952134
6* ZNF274_21170338_ChIP-Seq_K562_Hela2.71721073
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61330221
8FUS_26573619_Chip-Seq_HEK293_Human2.50889957
9VDR_22108803_ChIP-Seq_LS180_Human2.47774802
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47055888
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46518511
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36575427
13EZH2_22144423_ChIP-Seq_EOC_Human2.31704267
14IGF1R_20145208_ChIP-Seq_DFB_Human2.29656898
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22882138
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18214261
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16735231
18P300_19829295_ChIP-Seq_ESCs_Human2.07568054
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.05710691
20EWS_26573619_Chip-Seq_HEK293_Human2.02826555
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02329938
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.91010821
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72568499
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.69504519
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65843022
26SMAD4_21799915_ChIP-Seq_A2780_Human1.64378410
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.63460957
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60224474
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.59709597
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55159355
31RNF2_27304074_Chip-Seq_NSC_Mouse1.54921455
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54359092
33MYC_18940864_ChIP-ChIP_HL60_Human1.52298740
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49617790
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.49617167
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45411522
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44729592
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.43626367
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43623778
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43281815
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42048155
42* ETS1_20019798_ChIP-Seq_JURKAT_Human1.39187694
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38734424
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38497448
45CBP_20019798_ChIP-Seq_JUKART_Human1.38497448
46ER_23166858_ChIP-Seq_MCF-7_Human1.36843421
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36416882
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.35359528
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35347518
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.34610168
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34379751
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31334466
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.30541885
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29414214
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29367150
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.28668986
57REST_21632747_ChIP-Seq_MESCs_Mouse1.28526944
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26683915
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26492412
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25976844
61TP53_22573176_ChIP-Seq_HFKS_Human1.25556377
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25311303
63HTT_18923047_ChIP-ChIP_STHdh_Human1.25292508
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23088451
65VDR_23849224_ChIP-Seq_CD4+_Human1.22854323
66* TCF4_23295773_ChIP-Seq_U87_Human1.21550163
67SOX2_19829295_ChIP-Seq_ESCs_Human1.21008573
68NANOG_19829295_ChIP-Seq_ESCs_Human1.21008573
69* STAT3_23295773_ChIP-Seq_U87_Human1.20875574
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20858125
71AR_25329375_ChIP-Seq_VCAP_Human1.20710843
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.19066769
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.18157560
74P53_22387025_ChIP-Seq_ESCs_Mouse1.16208839
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15644783
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15255531
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15255531
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.14942365
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13400383
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12403292
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12401553
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11662461
83ELK1_19687146_ChIP-ChIP_HELA_Human1.11357288
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11218135
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10913458
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.09371804
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08265922
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07727658
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.07366365
90BCAT_22108803_ChIP-Seq_LS180_Human1.07092350
91AR_20517297_ChIP-Seq_VCAP_Human1.06847779
92JUN_21703547_ChIP-Seq_K562_Human1.06269741
93RUNX2_22187159_ChIP-Seq_PCA_Human1.05779000
94P300_18555785_Chip-Seq_ESCs_Mouse1.02892322
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02079196
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01136536
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.00822462
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00491220
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.00491220
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98352073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.14982887
2MP0002736_abnormal_nociception_after4.53783542
3MP0001968_abnormal_touch/_nociception3.80348637
4MP0003880_abnormal_central_pattern3.63572196
5MP0001529_abnormal_vocalization3.24948148
6MP0004142_abnormal_muscle_tone3.05096717
7MP0002168_other_aberrant_phenotype2.51487261
8MP0003195_calcinosis2.45107099
9MP0002909_abnormal_adrenal_gland2.38653614
10MP0003787_abnormal_imprinting2.28979087
11MP0005386_behavior/neurological_phenoty2.02215247
12MP0004924_abnormal_behavior2.02215247
13MP0005084_abnormal_gallbladder_morpholo1.99035105
14MP0004742_abnormal_vestibular_system1.92105092
15MP0009046_muscle_twitch1.86696638
16MP0006276_abnormal_autonomic_nervous1.82935841
17MP0002938_white_spotting1.82163089
18MP0005395_other_phenotype1.81526129
19MP0002067_abnormal_sensory_capabilities1.73026666
20MP0005253_abnormal_eye_physiology1.69054987
21MP0001756_abnormal_urination1.64840992
22MP0008877_abnormal_DNA_methylation1.63953881
23MP0000569_abnormal_digit_pigmentation1.62493722
24MP0001986_abnormal_taste_sensitivity1.61981851
25MP0001188_hyperpigmentation1.58509945
26MP0002735_abnormal_chemical_nociception1.57604190
27MP0004859_abnormal_synaptic_plasticity1.55824833
28MP0003635_abnormal_synaptic_transmissio1.53767768
29MP0002734_abnormal_mechanical_nocicepti1.48666344
30MP0009745_abnormal_behavioral_response1.48446023
31MP0001905_abnormal_dopamine_level1.47128091
32MP0006292_abnormal_olfactory_placode1.45090732
33MP0004133_heterotaxia1.44637116
34MP0002572_abnormal_emotion/affect_behav1.42433146
35MP0002064_seizures1.40402780
36MP0003122_maternal_imprinting1.39142676
37MP0002102_abnormal_ear_morphology1.36375507
38MP0001984_abnormal_olfaction1.36310217
39MP0002837_dystrophic_cardiac_calcinosis1.33288267
40MP0005551_abnormal_eye_electrophysiolog1.31947435
41MP0003011_delayed_dark_adaptation1.31515388
42MP0003121_genomic_imprinting1.31458304
43MP0002272_abnormal_nervous_system1.29169785
44MP0003941_abnormal_skin_development1.28749891
45MP0003693_abnormal_embryo_hatching1.28732893
46MP0000631_abnormal_neuroendocrine_gland1.26347933
47MP0004270_analgesia1.26177930
48MP0001764_abnormal_homeostasis1.25106005
49MP0004145_abnormal_muscle_electrophysio1.19002065
50MP0000778_abnormal_nervous_system1.17276578
51MP0001970_abnormal_pain_threshold1.15861515
52MP0005646_abnormal_pituitary_gland1.15504211
53MP0003890_abnormal_embryonic-extraembry1.15240649
54MP0005636_abnormal_mineral_homeostasis1.08893108
55MP0000955_abnormal_spinal_cord1.08799576
56MP0006072_abnormal_retinal_apoptosis1.08048595
57MP0002063_abnormal_learning/memory/cond1.08045024
58MP0001486_abnormal_startle_reflex1.07976679
59MP0006035_abnormal_mitochondrial_morpho1.03254176
60MP0005187_abnormal_penis_morphology1.01125384
61MP0005367_renal/urinary_system_phenotyp1.01065597
62MP0000516_abnormal_urinary_system1.01065597
63MP0002184_abnormal_innervation1.00969444
64MP0001440_abnormal_grooming_behavior1.00233251
65MP0005645_abnormal_hypothalamus_physiol0.98645678
66MP0002557_abnormal_social/conspecific_i0.97715598
67MP0001765_abnormal_ion_homeostasis0.97676157
68MP0005389_reproductive_system_phenotype0.97283416
69MP0003567_abnormal_fetal_cardiomyocyte0.96856675
70MP0004811_abnormal_neuron_physiology0.95467076
71MP0001177_atelectasis0.92592862
72MP0002733_abnormal_thermal_nociception0.92536489
73MP0004885_abnormal_endolymph0.90164799
74MP0002751_abnormal_autonomic_nervous0.85306867
75MP0000372_irregular_coat_pigmentation0.85027065
76MP0002066_abnormal_motor_capabilities/c0.84630243
77MP0003718_maternal_effect0.83173459
78MP0002882_abnormal_neuron_morphology0.82966201
79MP0001919_abnormal_reproductive_system0.81775163
80MP0002928_abnormal_bile_duct0.81657494
81MP0002160_abnormal_reproductive_system0.81638769
82MP0004215_abnormal_myocardial_fiber0.81349489
83MP0002752_abnormal_somatic_nervous0.81099835
84MP0008789_abnormal_olfactory_epithelium0.79813982
85MP0008569_lethality_at_weaning0.78059864
86MP0003137_abnormal_impulse_conducting0.77910900
87MP0001293_anophthalmia0.77579891
88MP0005408_hypopigmentation0.76787450
89MP0008995_early_reproductive_senescence0.76404824
90MP0005391_vision/eye_phenotype0.74818784
91MP0002229_neurodegeneration0.73813828
92MP0002138_abnormal_hepatobiliary_system0.72996010
93MP0000026_abnormal_inner_ear0.72866549
94MP0005195_abnormal_posterior_eye0.72568969
95MP0004085_abnormal_heartbeat0.71835107
96MP0002069_abnormal_eating/drinking_beha0.71326184
97MP0008875_abnormal_xenobiotic_pharmacok0.70302090
98MP0002152_abnormal_brain_morphology0.69756896
99MP0002233_abnormal_nose_morphology0.69606055
100MP0002210_abnormal_sex_determination0.69201196

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)9.09855991
2Chronic bronchitis (HP:0004469)7.89537295
3Hyperaldosteronism (HP:0000859)6.51568526
4Renal salt wasting (HP:0000127)6.32040761
5Hyperkalemia (HP:0002153)6.27820054
6Abnormality of renin-angiotensin system (HP:0000847)6.11778050
7Alkalosis (HP:0001948)4.65711497
8Hyponatremia (HP:0002902)4.52304900
9Hypokalemia (HP:0002900)4.35775736
10Abnormality of sodium homeostasis (HP:0010931)3.37963927
11Adrenal overactivity (HP:0002717)3.36919840
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.25898070
13Increased corneal curvature (HP:0100692)3.23396148
14Keratoconus (HP:0000563)3.23396148
15Decreased central vision (HP:0007663)3.20834095
16Pancreatic fibrosis (HP:0100732)3.13028165
17Limb dystonia (HP:0002451)3.05332852
18True hermaphroditism (HP:0010459)2.91967836
19Abnormality of potassium homeostasis (HP:0011042)2.84306753
203-Methylglutaconic aciduria (HP:0003535)2.82182088
21Bronchitis (HP:0012387)2.72793696
22Pancreatic cysts (HP:0001737)2.67047917
23Febrile seizures (HP:0002373)2.61519369
24Gait imbalance (HP:0002141)2.45411229
25Medial flaring of the eyebrow (HP:0010747)2.40580478
26Congenital primary aphakia (HP:0007707)2.39008014
27Increased hepatocellular lipid droplets (HP:0006565)2.38078394
28Abnormal rod and cone electroretinograms (HP:0008323)2.29943864
29Primary adrenal insufficiency (HP:0008207)2.28173323
30Bronchiectasis (HP:0002110)2.27772828
31Molar tooth sign on MRI (HP:0002419)2.27576476
32Abnormality of midbrain morphology (HP:0002418)2.27576476
33Type I transferrin isoform profile (HP:0003642)2.26430419
34Sclerocornea (HP:0000647)2.20728700
35Lipid accumulation in hepatocytes (HP:0006561)2.18109520
36Acute necrotizing encephalopathy (HP:0006965)2.16176280
37Hypothermia (HP:0002045)2.13391729
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11566143
39Nephrogenic diabetes insipidus (HP:0009806)2.10341932
40Short tibia (HP:0005736)2.09947863
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.04804856
42Rimmed vacuoles (HP:0003805)2.04631552
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01775630
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01775630
45Nephropathy (HP:0000112)2.01355822
46Epileptic encephalopathy (HP:0200134)2.01107585
47Mitochondrial inheritance (HP:0001427)2.00837495
48Decreased circulating renin level (HP:0003351)12.0886195
49Hyperactive renin-angiotensin system (HP:0000841)10.9373020
50Bile duct proliferation (HP:0001408)1.99181755
51Abnormal biliary tract physiology (HP:0012439)1.99181755
52Hypotension (HP:0002615)1.98379048
53Metabolic acidosis (HP:0001942)1.97634071
54Aplasia/Hypoplasia of the tongue (HP:0010295)1.96556066
55Chronic hepatic failure (HP:0100626)1.96537168
56Myokymia (HP:0002411)1.95782518
57Poor suck (HP:0002033)1.94272057
58Ankle clonus (HP:0011448)1.91900800
59Cystic liver disease (HP:0006706)1.91569362
60Supernumerary spleens (HP:0009799)1.91554172
61Type II lissencephaly (HP:0007260)1.90163930
62Vaginal atresia (HP:0000148)1.89989121
63Genital tract atresia (HP:0001827)1.86583539
64Abnormal mitochondria in muscle tissue (HP:0008316)1.84835266
65Progressive macrocephaly (HP:0004481)1.84738248
66Acute encephalopathy (HP:0006846)1.84115442
67Shoulder girdle muscle weakness (HP:0003547)1.83636861
68Hepatocellular necrosis (HP:0001404)1.82494649
69Atonic seizures (HP:0010819)1.82032670
70Thyroid-stimulating hormone excess (HP:0002925)1.81926678
71Poor coordination (HP:0002370)1.81254487
72Nephronophthisis (HP:0000090)1.80423548
73Flat cornea (HP:0007720)1.77518766
74Attenuation of retinal blood vessels (HP:0007843)1.75276511
75Bony spicule pigmentary retinopathy (HP:0007737)1.74599277
76Renal Fanconi syndrome (HP:0001994)1.72798037
77Postaxial foot polydactyly (HP:0001830)1.71515200
78Postaxial hand polydactyly (HP:0001162)1.70919591
79Abnormal protein glycosylation (HP:0012346)1.70611008
80Abnormal glycosylation (HP:0012345)1.70611008
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70611008
82Abnormal protein N-linked glycosylation (HP:0012347)1.70611008
83Abnormality of the renal medulla (HP:0100957)1.70364013
84Increased CSF lactate (HP:0002490)1.68939054
85Astigmatism (HP:0000483)1.68735517
86Median cleft lip (HP:0000161)1.65773501
87Anencephaly (HP:0002323)1.63532945
88Abnormality of the musculature of the pelvis (HP:0001469)1.63513930
89Abnormality of the hip-girdle musculature (HP:0001445)1.63513930
90Enlarged epiphyses (HP:0010580)1.61631543
91Congenital hepatic fibrosis (HP:0002612)1.61479014
92Dehydration (HP:0001944)1.59912169
93Optic nerve coloboma (HP:0000588)1.59804143
94Increased intramyocellular lipid droplets (HP:0012240)1.57717964
95Impaired vibration sensation in the lower limbs (HP:0002166)1.53761011
96Methylmalonic acidemia (HP:0002912)1.52075658
97Polyphagia (HP:0002591)1.51346439
98Urinary urgency (HP:0000012)1.48550349
99Pelvic girdle muscle weakness (HP:0003749)1.47230531
100Abnormality of the renal cortex (HP:0011035)1.46284441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.79475807
2MARK13.65985301
3EIF2AK32.81125377
4MAP2K72.76624470
5TESK12.73710042
6MAP3K42.72876388
7CASK2.67102121
8LIMK12.62234101
9TRIM282.54524309
10NME12.42548507
11BCR2.35887527
12ZAK2.18032520
13FRK2.11414532
14UHMK12.04826013
15MAP4K21.96056771
16DYRK1B1.94111723
17CSNK1G21.76345912
18CSNK1G31.76250207
19TLK11.71409345
20ADRBK21.70718243
21CSNK1G11.68422689
22PAK31.68284052
23BCKDK1.67195739
24PINK11.59610317
25PLK21.56560844
26ERBB31.55325125
27MAPK131.50243464
28TAOK31.47533771
29PLK41.45946737
30DYRK21.44613781
31DAPK21.36404772
32CSNK1A1L1.34692679
33TESK21.22297469
34YES11.08011184
35PRKCE1.07475924
36BMPR1B1.03621258
37STK391.01605158
38PRKG20.97849812
39CAMK2A0.96495617
40MAP2K40.94256645
41MAPKAPK50.86885666
42WNK40.85601094
43OXSR10.85252699
44MINK10.84975281
45EPHA40.84680624
46NEK20.83047381
47PRKCG0.81097886
48BRSK10.78246602
49PLK30.77473719
50SRPK10.74384868
51DYRK30.71166041
52GRK10.69901698
53TYRO30.69367671
54CDK50.67652015
55OBSCN0.66175945
56CAMK2B0.64360426
57NUAK10.63997772
58RPS6KA50.62406914
59GRK70.62346179
60SGK20.60898479
61TEC0.60443750
62CSNK1E0.59577683
63PKN10.55797385
64CSNK1D0.55681088
65TIE10.55426883
66MUSK0.52591223
67MAP3K120.52381814
68PRKACA0.51872858
69ADRBK10.51825594
70PRKACB0.51296846
71DYRK1A0.50693971
72PLK10.48303980
73TSSK60.46806765
74INSRR0.43353864
75CAMK2D0.43305076
76PHKG20.39382507
77PHKG10.39382507
78PIM10.39208590
79DAPK10.39200910
80SGK2230.38306246
81SGK4940.38306246
82SIK30.38269835
83CAMK2G0.38265857
84PRKCA0.36448960
85STK110.36260431
86BUB10.35560387
87ATR0.34925810
88PRKG10.34154308
89CAMKK20.33427383
90AURKA0.33182442
91BRSK20.32525609
92CSNK1A10.32280372
93CDK140.31051515
94PRKCZ0.29914690
95VRK10.29901133
96AKT30.29482510
97RPS6KA40.29450247
98MAP2K20.29067286
99MKNK20.28560134
100CSNK2A20.27373834

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.12897106
2Taste transduction_Homo sapiens_hsa047423.69166901
3Parkinsons disease_Homo sapiens_hsa050123.55427696
4Proteasome_Homo sapiens_hsa030502.78901786
5Cardiac muscle contraction_Homo sapiens_hsa042602.58617857
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.46483692
7Alzheimers disease_Homo sapiens_hsa050102.45254617
8Huntingtons disease_Homo sapiens_hsa050162.26700513
9Protein export_Homo sapiens_hsa030602.13748458
10Tryptophan metabolism_Homo sapiens_hsa003802.13563129
11Basal transcription factors_Homo sapiens_hsa030222.13306653
12Histidine metabolism_Homo sapiens_hsa003401.99549964
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94353921
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88253964
15Morphine addiction_Homo sapiens_hsa050321.79767192
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79444128
17Collecting duct acid secretion_Homo sapiens_hsa049661.71629321
18Regulation of autophagy_Homo sapiens_hsa041401.69093548
19Folate biosynthesis_Homo sapiens_hsa007901.65357817
20Nicotine addiction_Homo sapiens_hsa050331.64117544
21GABAergic synapse_Homo sapiens_hsa047271.63596903
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55703322
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48546281
24Dopaminergic synapse_Homo sapiens_hsa047281.48372495
25Pyruvate metabolism_Homo sapiens_hsa006201.45923297
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37044130
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33948033
28Arginine and proline metabolism_Homo sapiens_hsa003301.33506326
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31395801
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30860298
31Amphetamine addiction_Homo sapiens_hsa050311.30408147
32Homologous recombination_Homo sapiens_hsa034401.26333977
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.25076024
34Circadian entrainment_Homo sapiens_hsa047131.24150193
35Synaptic vesicle cycle_Homo sapiens_hsa047211.23628428
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20831320
37Linoleic acid metabolism_Homo sapiens_hsa005911.20688424
38Insulin secretion_Homo sapiens_hsa049111.19416914
39Phototransduction_Homo sapiens_hsa047441.15580983
40Selenocompound metabolism_Homo sapiens_hsa004501.13985027
41Propanoate metabolism_Homo sapiens_hsa006401.10290356
42Olfactory transduction_Homo sapiens_hsa047401.07901479
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05124219
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03655702
45Glutamatergic synapse_Homo sapiens_hsa047240.99615437
46Cocaine addiction_Homo sapiens_hsa050300.98915408
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98099331
48Renin secretion_Homo sapiens_hsa049240.97423856
49Butanoate metabolism_Homo sapiens_hsa006500.96121684
50Serotonergic synapse_Homo sapiens_hsa047260.87943387
51Base excision repair_Homo sapiens_hsa034100.82950755
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82372129
53Nitrogen metabolism_Homo sapiens_hsa009100.81505538
54Vibrio cholerae infection_Homo sapiens_hsa051100.78474925
55Purine metabolism_Homo sapiens_hsa002300.78154777
56Caffeine metabolism_Homo sapiens_hsa002320.76237748
57beta-Alanine metabolism_Homo sapiens_hsa004100.70855038
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69599719
59Cholinergic synapse_Homo sapiens_hsa047250.69162973
60Fanconi anemia pathway_Homo sapiens_hsa034600.68630995
61RNA transport_Homo sapiens_hsa030130.67744415
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.65949651
63Oocyte meiosis_Homo sapiens_hsa041140.61848154
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61711229
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61434778
66N-Glycan biosynthesis_Homo sapiens_hsa005100.61221600
67Metabolic pathways_Homo sapiens_hsa011000.60291807
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59801199
69Steroid biosynthesis_Homo sapiens_hsa001000.59586818
70Tyrosine metabolism_Homo sapiens_hsa003500.59371738
71Ether lipid metabolism_Homo sapiens_hsa005650.57217509
72Peroxisome_Homo sapiens_hsa041460.56362279
73Thyroid hormone synthesis_Homo sapiens_hsa049180.55029452
74Long-term depression_Homo sapiens_hsa047300.54857484
75Gastric acid secretion_Homo sapiens_hsa049710.54510798
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52105740
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50856169
78RNA polymerase_Homo sapiens_hsa030200.49763750
79ABC transporters_Homo sapiens_hsa020100.49358260
80Vitamin digestion and absorption_Homo sapiens_hsa049770.48064052
81RNA degradation_Homo sapiens_hsa030180.47895247
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43920460
83Salivary secretion_Homo sapiens_hsa049700.42603129
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40002756
85Nucleotide excision repair_Homo sapiens_hsa034200.38930244
86mRNA surveillance pathway_Homo sapiens_hsa030150.38821956
87Ovarian steroidogenesis_Homo sapiens_hsa049130.36828755
88Spliceosome_Homo sapiens_hsa030400.36696411
89Glycerolipid metabolism_Homo sapiens_hsa005610.36512597
90Axon guidance_Homo sapiens_hsa043600.36089778
91Alcoholism_Homo sapiens_hsa050340.35497650
92Calcium signaling pathway_Homo sapiens_hsa040200.34834831
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32498231
94cAMP signaling pathway_Homo sapiens_hsa040240.29476987
95Gap junction_Homo sapiens_hsa045400.28756774
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.27849552
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27532320
98Mismatch repair_Homo sapiens_hsa034300.26711363
99Oxytocin signaling pathway_Homo sapiens_hsa049210.26415204
100Dilated cardiomyopathy_Homo sapiens_hsa054140.26071792

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