ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.07222905
2	chaperone-mediated protein transport (GO:0072321)	6.85828088
3	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.40075608
4	viral transcription (GO:0019083)	6.08871237
5	outer ear morphogenesis (GO:0042473)	5.82003532
6	translational termination (GO:0006415)	5.80725392
7	muscle organ morphogenesis (GO:0048644)	5.73869886
8	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.71441719
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.63075648
10	maturation of SSU-rRNA (GO:0030490)	5.60373315
11	pyrimidine nucleotide catabolic process (GO:0006244)	5.53265481
12	GTP biosynthetic process (GO:0006183)	5.39798326
13	termination of RNA polymerase III transcription (GO:0006386)	5.15108166
14	transcription elongation from RNA polymerase III promoter (GO:0006385)	5.15108166
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.09793352
16	ATP synthesis coupled proton transport (GO:0015986)	5.09793352
17	translational elongation (GO:0006414)	5.09626199
18	UTP biosynthetic process (GO:0006228)	5.06851294
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.99224804
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.97331439
21	respiratory electron transport chain (GO:0022904)	4.93114497
22	cotranslational protein targeting to membrane (GO:0006613)	4.87598765
23	protein targeting to ER (GO:0045047)	4.81197002
24	guanosine-containing compound biosynthetic process (GO:1901070)	4.80528243
25	electron transport chain (GO:0022900)	4.79698043
26	protein targeting to mitochondrion (GO:0006626)	4.78642729
27	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.74969785
28	NADH dehydrogenase complex assembly (GO:0010257)	4.72131264
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.72131264
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.72131264
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.60674007
32	UTP metabolic process (GO:0046051)	4.59862765
33	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.57432859
34	ribosomal small subunit assembly (GO:0000028)	4.56926477
35	peptidyl-histidine modification (GO:0018202)	4.55802022
36	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.49771788
37	protein localization to endoplasmic reticulum (GO:0070972)	4.46852630
38	cellular protein complex disassembly (GO:0043624)	4.43622002
39	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.39353236
40	CTP biosynthetic process (GO:0006241)	4.32174518
41	CTP metabolic process (GO:0046036)	4.32174518
42	ribonucleoprotein complex biogenesis (GO:0022613)	4.32030778
43	translation (GO:0006412)	4.27658312
44	viral life cycle (GO:0019058)	4.25155879
45	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.24877163
46	establishment of protein localization to mitochondrion (GO:0072655)	4.23010951
47	translational initiation (GO:0006413)	4.21801611
48	cellular component biogenesis (GO:0044085)	4.17732884
49	heterochromatin organization (GO:0070828)	4.17175658
50	mitochondrial respiratory chain complex assembly (GO:0033108)	4.15396554
51	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.14358540
52	protein complex biogenesis (GO:0070271)	4.13788221
53	protein localization to mitochondrion (GO:0070585)	4.13150507
54	response to redox state (GO:0051775)	4.07827724
55	tooth mineralization (GO:0034505)	4.07247927
56	rRNA processing (GO:0006364)	3.98315022
57	ribosomal large subunit biogenesis (GO:0042273)	3.95144690
58	pseudouridine synthesis (GO:0001522)	3.93149229
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.91474981
60	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.89310207
61	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.84603453
62	rRNA metabolic process (GO:0016072)	3.82198879
63	protein-cofactor linkage (GO:0018065)	3.82077172
64	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.81515644
65	cardiovascular system development (GO:0072358)	3.78546613
66	regulation of mitochondrial translation (GO:0070129)	3.76912616
67	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.75693148
68	protein complex disassembly (GO:0043241)	3.70648804
69	spliceosomal snRNP assembly (GO:0000387)	3.67282972
70	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.67046837
71	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.66618764
72	deoxyribonucleotide catabolic process (GO:0009264)	3.62059471
73	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.60316208
74	grooming behavior (GO:0007625)	3.60057674
75	protein maturation by protein folding (GO:0022417)	3.58231372
76	base-excision repair, AP site formation (GO:0006285)	3.49839742
77	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.49631311
78	macromolecular complex disassembly (GO:0032984)	3.47754088
79	pyrimidine nucleotide metabolic process (GO:0006220)	3.45099553
80	ATP biosynthetic process (GO:0006754)	3.44636031
81	GMP metabolic process (GO:0046037)	3.42853804
82	intracellular protein transmembrane import (GO:0044743)	3.39449711
83	proteasome assembly (GO:0043248)	3.37955855
84	pyrimidine nucleoside biosynthetic process (GO:0046134)	3.36636855
85	respiratory chain complex IV assembly (GO:0008535)	3.36149595
86	deoxyribose phosphate catabolic process (GO:0046386)	3.33925078
87	DNA deamination (GO:0045006)	3.32757874
88	DNA replication-dependent nucleosome assembly (GO:0006335)	3.32075324
89	DNA replication-dependent nucleosome organization (GO:0034723)	3.32075324
90	nucleoside diphosphate phosphorylation (GO:0006165)	3.25208133
91	nucleoside triphosphate biosynthetic process (GO:0009142)	3.24128374
92	ribosome biogenesis (GO:0042254)	3.22790637
93	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.21361524
94	protein targeting to membrane (GO:0006612)	3.20124721
95	nucleoside salvage (GO:0043174)	3.19730575
96	chromatin remodeling at centromere (GO:0031055)	3.18466618
97	kinetochore assembly (GO:0051382)	3.16074743
98	negative regulation of RNA splicing (GO:0033119)	3.15509554
99	mitochondrial transport (GO:0006839)	3.14552813
100	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.14221801

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.41400384
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.25297542
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.11881602
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.11021024
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.06509637
6	* ETS1_20019798_ChIP-Seq_JURKAT_Human	3.66200136
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.37552395
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.36279342
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.16300943
10	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08448632
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.05125992
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.00657346
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.89454642
14	XRN2_22483619_ChIP-Seq_HELA_Human	2.70874562
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68495061
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.67462697
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.63261556
18	DCP1A_22483619_ChIP-Seq_HELA_Human	2.62322685
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.62245977
20	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.55397442
21	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.39288097
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.34464836
23	* GABP_19822575_ChIP-Seq_HepG2_Human	2.33950775
24	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.25957590
25	* VDR_23849224_ChIP-Seq_CD4+_Human	2.20652092
26	TTF2_22483619_ChIP-Seq_HELA_Human	2.15884062
27	E2F7_22180533_ChIP-Seq_HELA_Human	2.15417596
28	FOXP3_21729870_ChIP-Seq_TREG_Human	2.06308372
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.04528688
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.02076224
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.96379878
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.85774868
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.80499351
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73413763
35	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.71341361
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69509083
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.67247922
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.64366617
39	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.63513444
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60614962
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.55553402
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.50586239
43	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49531383
44	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.48210414
45	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.46583911
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.44808777
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33847821
48	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.32019693
49	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.31846654
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30691804
51	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29968280
52	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.29150839
53	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.27004395
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26782930
55	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.23809471
56	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.20355762
57	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.17917647
58	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.17306007
59	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.15822367
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.15445871
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.15276295
62	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.14426947
63	KDM5A_27292631_Chip-Seq_BREAST_Human	1.13276185
64	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.13246527
65	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.12481786
66	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.11688266
67	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.11688266
68	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.11688266
69	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.11103498
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10694779
71	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.09793734
72	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.08728724
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.04700546
74	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.04607731
75	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04491179
76	FUS_26573619_Chip-Seq_HEK293_Human	1.03906401
77	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03389714
78	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.02911200
79	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.02719664
80	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.02417592
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99687763
82	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.99583761
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.98255698
84	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.97004339
85	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92070604
86	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.91362126
87	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.91089695
88	ZNF263_19887448_ChIP-Seq_K562_Human	0.89982214
89	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.89969308
90	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.89863753
91	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89762241
92	P68_20966046_ChIP-Seq_HELA_Human	0.89720146
93	AR_21909140_ChIP-Seq_LNCAP_Human	0.88941804
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.88668177
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.88140641
96	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.86211189
97	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.85675799
98	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.85148358
99	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.83066490
100	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.82401851

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000678_abnormal_parathyroid_gland	4.25286775
2	MP0009379_abnormal_foot_pigmentation	3.56333428
3	MP0005499_abnormal_olfactory_system	3.19298802
4	MP0005394_taste/olfaction_phenotype	3.19298802
5	MP0002277_abnormal_respiratory_mucosa	3.15612572
6	MP0000049_abnormal_middle_ear	3.03287541
7	MP0003806_abnormal_nucleotide_metabolis	2.99464927
8	MP0003123_paternal_imprinting	2.95057559
9	MP0003693_abnormal_embryo_hatching	2.88751840
10	MP0001188_hyperpigmentation	2.58871944
11	MP0008875_abnormal_xenobiotic_pharmacok	2.50386130
12	MP0006292_abnormal_olfactory_placode	2.48821564
13	MP0002163_abnormal_gland_morphology	2.40235666
14	MP0002234_abnormal_pharynx_morphology	2.36957215
15	MP0002249_abnormal_larynx_morphology	2.29334511
16	MP0008789_abnormal_olfactory_epithelium	2.26639383
17	MP0004858_abnormal_nervous_system	2.18019457
18	MP0009046_muscle_twitch	1.98668655
19	MP0006036_abnormal_mitochondrial_physio	1.93225878
20	MP0008932_abnormal_embryonic_tissue	1.84471041
21	MP0003186_abnormal_redox_activity	1.82146629
22	MP0002837_dystrophic_cardiac_calcinosis	1.82051275
23	MP0000467_abnormal_esophagus_morphology	1.77913296
24	MP0005646_abnormal_pituitary_gland	1.69981634
25	MP0001270_distended_abdomen	1.57934067
26	MP0002160_abnormal_reproductive_system	1.57044250
27	MP0002638_abnormal_pupillary_reflex	1.56558451
28	MP0002877_abnormal_melanocyte_morpholog	1.54366577
29	MP0006035_abnormal_mitochondrial_morpho	1.53322016
30	MP0001879_abnormal_lymphatic_vessel	1.50966066
31	MP0008058_abnormal_DNA_repair	1.50866002
32	MP0002102_abnormal_ear_morphology	1.50856213
33	MP0000631_abnormal_neuroendocrine_gland	1.50663921
34	MP0000749_muscle_degeneration	1.45315660
35	MP0003786_premature_aging	1.43718537
36	MP0002177_abnormal_outer_ear	1.42341845
37	MP0003880_abnormal_central_pattern	1.42208297
38	MP0001529_abnormal_vocalization	1.40538745
39	MP0000681_abnormal_thyroid_gland	1.36697502
40	MP0005187_abnormal_penis_morphology	1.36358691
41	MP0002932_abnormal_joint_morphology	1.35804911
42	MP0009250_abnormal_appendicular_skeleto	1.28530749
43	MP0009745_abnormal_behavioral_response	1.27768780
44	MP0005379_endocrine/exocrine_gland_phen	1.27123524
45	MP0003938_abnormal_ear_development	1.25576098
46	MP0001764_abnormal_homeostasis	1.21719343
47	MP0003077_abnormal_cell_cycle	1.21177953
48	MP0004957_abnormal_blastocyst_morpholog	1.19731002
49	MP0002064_seizures	1.12309106
50	MP0003121_genomic_imprinting	1.05829520
51	MP0004142_abnormal_muscle_tone	1.05375659
52	MP0003567_abnormal_fetal_cardiomyocyte	1.05338542
53	MP0003111_abnormal_nucleus_morphology	1.04308376
54	MP0006276_abnormal_autonomic_nervous	1.03513423
55	MP0002938_white_spotting	1.02596858
56	MP0002736_abnormal_nociception_after	1.02568068
57	MP0010094_abnormal_chromosome_stability	1.01207865
58	MP0001905_abnormal_dopamine_level	1.00063259
59	MP0005389_reproductive_system_phenotype	0.99757476
60	MP0003136_yellow_coat_color	0.99625607
61	MP0002876_abnormal_thyroid_physiology	0.99061220
62	MP0003315_abnormal_perineum_morphology	0.98065896
63	MP0003937_abnormal_limbs/digits/tail_de	0.97254141
64	MP0008007_abnormal_cellular_replicative	0.96658008
65	MP0005551_abnormal_eye_electrophysiolog	0.95333671
66	MP0001984_abnormal_olfaction	0.94256300
67	MP0004145_abnormal_muscle_electrophysio	0.93610168
68	MP0001968_abnormal_touch/_nociception	0.92811648
69	MP0006072_abnormal_retinal_apoptosis	0.88333469
70	MP0002233_abnormal_nose_morphology	0.87873842
71	MP0003755_abnormal_palate_morphology	0.87482547
72	MP0009053_abnormal_anal_canal	0.84012518
73	MP0001881_abnormal_mammary_gland	0.82548947
74	MP0002184_abnormal_innervation	0.81382936
75	MP0000026_abnormal_inner_ear	0.80876644
76	MP0005409_darkened_coat_color	0.80262235
77	MP0008872_abnormal_physiological_respon	0.79431697
78	MP0001919_abnormal_reproductive_system	0.78044500
79	MP0004811_abnormal_neuron_physiology	0.76345910
80	MP0000534_abnormal_ureter_morphology	0.73897065
81	MP0010307_abnormal_tumor_latency	0.73863495
82	MP0005195_abnormal_posterior_eye	0.73213622
83	MP0002697_abnormal_eye_size	0.70121531
84	MP0003646_muscle_fatigue	0.70098573
85	MP0002272_abnormal_nervous_system	0.69898632
86	MP0002095_abnormal_skin_pigmentation	0.64863531
87	MP0002210_abnormal_sex_determination	0.63997364
88	MP0002111_abnormal_tail_morphology	0.63895475
89	MP0002114_abnormal_axial_skeleton	0.63830561
90	MP0000372_irregular_coat_pigmentation	0.63519073
91	MP0002127_abnormal_cardiovascular_syste	0.63269314
92	MP0000762_abnormal_tongue_morphology	0.62391977
93	MP0001293_anophthalmia	0.61972457
94	MP0001963_abnormal_hearing_physiology	0.61214949
95	MP0005332_abnormal_amino_acid	0.59552264
96	MP0001145_abnormal_male_reproductive	0.58990376
97	MP0002752_abnormal_somatic_nervous	0.58918105
98	MP0004885_abnormal_endolymph	0.57809895
99	MP0002116_abnormal_craniofacial_bone	0.57127396
100	MP0005084_abnormal_gallbladder_morpholo	0.56986671

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Renal Fanconi syndrome (HP:0001994)	5.96531076
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.12654043
3	Increased hepatocellular lipid droplets (HP:0006565)	4.73071958
4	Acute necrotizing encephalopathy (HP:0006965)	4.66986359
5	Mitochondrial inheritance (HP:0001427)	4.33501721
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.22878975
7	Lipid accumulation in hepatocytes (HP:0006561)	4.10029588
8	Increased intramyocellular lipid droplets (HP:0012240)	4.08236408
9	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.90791011
10	Progressive macrocephaly (HP:0004481)	3.78979741
11	Increased CSF lactate (HP:0002490)	3.78526907
12	Acute encephalopathy (HP:0006846)	3.70965914
13	Overriding aorta (HP:0002623)	3.70027276
14	Microretrognathia (HP:0000308)	3.62394162
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.48887781
16	Abnormality of renal resorption (HP:0011038)	3.47864802
17	Increased muscle lipid content (HP:0009058)	3.43972228
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.38599129
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.38599129
20	Elfin facies (HP:0004428)	3.26858128
21	Abnormal rod and cone electroretinograms (HP:0008323)	3.25493458
22	Congenital malformation of the right heart (HP:0011723)	3.24604258
23	Double outlet right ventricle (HP:0001719)	3.24604258
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.16056882
25	Cerebral edema (HP:0002181)	3.15226343
26	Generalized aminoaciduria (HP:0002909)	3.00270196
27	Hepatocellular necrosis (HP:0001404)	2.99486999
28	Exertional dyspnea (HP:0002875)	2.97434729
29	Abnormal number of erythroid precursors (HP:0012131)	2.95154658
30	Testicular atrophy (HP:0000029)	2.90416570
31	Glycosuria (HP:0003076)	2.86952897
32	Abnormality of urine glucose concentration (HP:0011016)	2.86952897
33	Macrocytic anemia (HP:0001972)	2.85946734
34	Abnormal number of incisors (HP:0011064)	2.83229016
35	Increased serum lactate (HP:0002151)	2.82466961
36	3-Methylglutaconic aciduria (HP:0003535)	2.76769326
37	Respiratory difficulties (HP:0002880)	2.74066718
38	Abnormality of cells of the erythroid lineage (HP:0012130)	2.72089228
39	Chronic bronchitis (HP:0004469)	2.70433015
40	Renovascular hypertension (HP:0100817)	2.68497082
41	Abnormality of the aortic arch (HP:0012303)	2.62994278
42	Hyperacusis (HP:0010780)	2.62322562
43	Rectal prolapse (HP:0002035)	2.62321267
44	Hepatic necrosis (HP:0002605)	2.61715531
45	Exercise intolerance (HP:0003546)	2.59372941
46	Unilateral renal agenesis (HP:0000122)	2.57513447
47	Abnormal respiratory motile cilium physiology (HP:0012261)	2.56256943
48	Lactic acidosis (HP:0003128)	2.55160749
49	Redundant skin (HP:0001582)	2.54040954
50	Hyperthyroidism (HP:0000836)	2.53005417
51	Insomnia (HP:0100785)	2.52864196
52	Flat cornea (HP:0007720)	2.51504987
53	Renal duplication (HP:0000075)	2.42637713
54	Posterior embryotoxon (HP:0000627)	2.42267160
55	Hypophosphatemic rickets (HP:0004912)	2.41765311
56	Leukodystrophy (HP:0002415)	2.34729696
57	Periauricular skin pits (HP:0100277)	2.31573735
58	Preauricular pit (HP:0004467)	2.31573735
59	Abnormality of the line of Schwalbe (HP:0008048)	2.31244563
60	Gout (HP:0001997)	2.29664264
61	Abnormality of the parathyroid morphology (HP:0011766)	2.27452202
62	Down-sloping shoulders (HP:0200021)	2.23335949
63	Respiratory failure (HP:0002878)	2.20180789
64	Progressive muscle weakness (HP:0003323)	2.13090749
65	Hyperphosphaturia (HP:0003109)	2.12760371
66	Polydipsia (HP:0001959)	2.07877802
67	Abnormal drinking behavior (HP:0030082)	2.07877802
68	Constricted visual fields (HP:0001133)	2.04435457
69	Tetany (HP:0001281)	2.03835563
70	Cleft eyelid (HP:0000625)	2.03271418
71	Optic disc pallor (HP:0000543)	2.02619056
72	Myokymia (HP:0002411)	2.02411877
73	Transposition of the great arteries (HP:0001669)	1.99751470
74	Abnormal connection of the cardiac segments (HP:0011545)	1.99751470
75	Abnormal ventriculo-arterial connection (HP:0011563)	1.99751470
76	Abnormality of the costochondral junction (HP:0000919)	1.98848499
77	Progressive microcephaly (HP:0000253)	1.98728049
78	Triphalangeal thumb (HP:0001199)	1.98661999
79	Pendular nystagmus (HP:0012043)	1.97023255
80	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.96684999
81	Abnormality of the diencephalon (HP:0010662)	1.94683545
82	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94388161
83	Absent/shortened dynein arms (HP:0200106)	1.94388161
84	Selective tooth agenesis (HP:0001592)	1.93905374
85	Failure to thrive in infancy (HP:0001531)	1.92801498
86	Reticulocytopenia (HP:0001896)	1.91644837
87	Broad distal phalanx of finger (HP:0009836)	1.91000958
88	Partial duplication of thumb phalanx (HP:0009944)	1.90227719
89	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88939450
90	Abnormality of alanine metabolism (HP:0010916)	1.88939450
91	Hyperalaninemia (HP:0003348)	1.88939450
92	Abnormality of midbrain morphology (HP:0002418)	1.88189427
93	Molar tooth sign on MRI (HP:0002419)	1.88189427
94	Hypercalcemia (HP:0003072)	1.85934322
95	Patellar dislocation (HP:0002999)	1.84368611
96	Hypoplastic left heart (HP:0004383)	1.82331793
97	Occipital encephalocele (HP:0002085)	1.81816830
98	Truncus arteriosus (HP:0001660)	1.79951262
99	Abnormality of the carotid arteries (HP:0005344)	1.76805987
100	Rhinitis (HP:0012384)	1.74527460

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	9.84195321
2	BUB1	4.98512183
3	LIMK1	4.30554789
4	BCKDK	3.33414481
5	CCNB1	1.97748726
6	STK16	1.79101044
7	BMPR1B	1.78427569
8	MAP2K7	1.74879707
9	PDK2	1.69374631
10	LRRK2	1.66006224
11	MAP4K2	1.64973471
12	SRPK1	1.53746815
13	MAP3K9	1.36768053
14	WEE1	1.34983605
15	ABL2	1.34156321
16	ILK	1.33662806
17	CASK	1.28594202
18	DYRK3	1.24070365
19	GRK1	1.23021828
20	PLK4	1.22197463
21	CDC42BPA	1.16873213
22	PINK1	1.14731980
23	CDC7	1.05421183
24	LATS1	1.03442773
25	DYRK2	1.02647217
26	PLK1	1.01227994
27	BRAF	0.98632070
28	PRKCG	0.94394025
29	MAP3K6	0.93960476
30	TRIM28	0.93094045
31	PRKCI	0.92154253
32	MAP3K11	0.91641251
33	PIM2	0.86964800
34	TLK1	0.86505383
35	PBK	0.84939473
36	MINK1	0.84422876
37	ATR	0.83499192
38	ZAK	0.83117471
39	NME1	0.80737334
40	ACVR1B	0.79526196
41	CSNK2A2	0.79438945
42	AURKA	0.78063387
43	CSNK2A1	0.77554047
44	CAMK1D	0.76671664
45	NEK1	0.76517871
46	WNK3	0.73744600
47	DYRK1A	0.73492331
48	BRSK1	0.71008197
49	INSRR	0.69480301
50	ARAF	0.69280834
51	CHEK1	0.66174512
52	ADRBK2	0.63473887
53	AKT2	0.63391490
54	MAP2K2	0.62988258
55	PKN2	0.62511118
56	AURKB	0.61353144
57	BRSK2	0.61087650
58	CDK15	0.60767809
59	TTK	0.58700981
60	STK3	0.58629618
61	CDK11A	0.58080709
62	ATM	0.57293279
63	CDK18	0.55181397
64	VRK1	0.53426156
65	EIF2AK1	0.53297824
66	RPS6KA5	0.50829068
67	STK4	0.49812383
68	CDK14	0.49299093
69	PAK1	0.49276347
70	NUAK1	0.48871615
71	MAP3K4	0.48738751
72	CDK4	0.47873153
73	CDK1	0.47272902
74	PDPK1	0.47047647
75	MARK1	0.46829363
76	MAP3K13	0.46145821
77	CDK2	0.46050261
78	CSNK1E	0.45531819
79	MAPK15	0.44775345
80	ROCK2	0.44281082
81	PIM1	0.41512799
82	VRK2	0.40753772
83	MAPK13	0.39935916
84	CDK5	0.39705357
85	DYRK1B	0.38153187
86	EPHA3	0.36670334
87	MAP2K4	0.36153854
88	CHEK2	0.33790889
89	PRKACA	0.32938002
90	ADRBK1	0.32210012
91	CAMK1	0.31793386
92	CSNK1D	0.31419524
93	CDK7	0.30463382
94	MAPKAPK3	0.29823871
95	FRK	0.29148074
96	CAMK2B	0.28896171
97	PRKCZ	0.28862542
98	OBSCN	0.28530048
99	WNK4	0.28506707
100	RPS6KA4	0.27812604

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.14421438
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.97584602
3	Parkinsons disease_Homo sapiens_hsa05012	4.35108073
4	RNA polymerase_Homo sapiens_hsa03020	3.96041363
5	Huntingtons disease_Homo sapiens_hsa05016	3.27852477
6	DNA replication_Homo sapiens_hsa03030	3.05037082
7	Alzheimers disease_Homo sapiens_hsa05010	2.92964357
8	Pyrimidine metabolism_Homo sapiens_hsa00240	2.88397629
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.77729747
10	One carbon pool by folate_Homo sapiens_hsa00670	2.59977239
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37635483
12	Spliceosome_Homo sapiens_hsa03040	2.27659647
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.03543409
14	Homologous recombination_Homo sapiens_hsa03440	2.01713871
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.90484136
16	Proteasome_Homo sapiens_hsa03050	1.83937250
17	Mismatch repair_Homo sapiens_hsa03430	1.68602673
18	Purine metabolism_Homo sapiens_hsa00230	1.59113525
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59091905
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.55586521
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.49088921
22	Base excision repair_Homo sapiens_hsa03410	1.46484685
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.44484323
24	Protein export_Homo sapiens_hsa03060	1.43949396
25	RNA transport_Homo sapiens_hsa03013	1.34203659
26	Phototransduction_Homo sapiens_hsa04744	1.29964919
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21587141
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.21134670
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15553740
30	RNA degradation_Homo sapiens_hsa03018	1.10570669
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.09724426
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.03409677
33	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.99146744
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.97710150
35	Pyruvate metabolism_Homo sapiens_hsa00620	0.97295192
36	Sulfur relay system_Homo sapiens_hsa04122	0.96341849
37	Metabolic pathways_Homo sapiens_hsa01100	0.95564243
38	Nitrogen metabolism_Homo sapiens_hsa00910	0.93821011
39	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.91595399
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90190835
41	Arginine and proline metabolism_Homo sapiens_hsa00330	0.88081489
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86915350
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86390974
44	Sulfur metabolism_Homo sapiens_hsa00920	0.78982581
45	Phenylalanine metabolism_Homo sapiens_hsa00360	0.74611456
46	Basal transcription factors_Homo sapiens_hsa03022	0.72634049
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.67441946
48	Cell cycle_Homo sapiens_hsa04110	0.65076867
49	Peroxisome_Homo sapiens_hsa04146	0.61878676
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57931326
51	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.54693582
52	Tyrosine metabolism_Homo sapiens_hsa00350	0.54436543
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.49465229
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46804858
55	Nicotine addiction_Homo sapiens_hsa05033	0.46779408
56	mRNA surveillance pathway_Homo sapiens_hsa03015	0.43959392
57	Glutathione metabolism_Homo sapiens_hsa00480	0.40258526
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39787341
59	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.38854721
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.38668021
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32755545
62	Morphine addiction_Homo sapiens_hsa05032	0.31917665
63	Linoleic acid metabolism_Homo sapiens_hsa00591	0.30865297
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30824922
65	Folate biosynthesis_Homo sapiens_hsa00790	0.29206952
66	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.28082155
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27239402
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.27136990
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.26684824
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.23793766
71	Propanoate metabolism_Homo sapiens_hsa00640	0.23782617
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22061255
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.22042716
74	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.20841550
75	Alcoholism_Homo sapiens_hsa05034	0.20802618
76	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.20390789
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.19402385
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.18738805
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.18658908
80	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.17948600
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.16967063
82	Fatty acid elongation_Homo sapiens_hsa00062	0.16824360
83	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.15866614
84	Steroid biosynthesis_Homo sapiens_hsa00100	0.15452999
85	Ether lipid metabolism_Homo sapiens_hsa00565	0.13679064
86	Vibrio cholerae infection_Homo sapiens_hsa05110	0.12689716
87	Tryptophan metabolism_Homo sapiens_hsa00380	0.12473531
88	Taste transduction_Homo sapiens_hsa04742	0.12105579
89	p53 signaling pathway_Homo sapiens_hsa04115	0.11864259
90	Olfactory transduction_Homo sapiens_hsa04740	0.11333775
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.11034640
92	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.09872558
93	Circadian entrainment_Homo sapiens_hsa04713	0.05841651
94	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.05679203
95	Serotonergic synapse_Homo sapiens_hsa04726	0.04301475
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.04161676
97	Retinol metabolism_Homo sapiens_hsa00830	0.04065148
98	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.04061755
99	Butanoate metabolism_Homo sapiens_hsa00650	0.03144801
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.02993797

ZNF3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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