ZNF30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)3.97572509
2DNA double-strand break processing (GO:0000729)3.90274673
3peptidyl-histidine modification (GO:0018202)3.66590507
4cullin deneddylation (GO:0010388)3.63934031
5resolution of meiotic recombination intermediates (GO:0000712)3.48774632
6cholesterol biosynthetic process (GO:0006695)3.48039391
7DNA damage response, detection of DNA damage (GO:0042769)3.47905926
8sterol biosynthetic process (GO:0016126)3.44571916
9protein localization to kinetochore (GO:0034501)3.38987487
10protein deneddylation (GO:0000338)3.28712353
11intraciliary transport (GO:0042073)3.27899920
12response to pheromone (GO:0019236)3.26724649
13chromatin remodeling at centromere (GO:0031055)3.26206258
14protein neddylation (GO:0045116)3.21593633
15CENP-A containing nucleosome assembly (GO:0034080)3.20259023
16pyrimidine nucleobase catabolic process (GO:0006208)3.17920023
17kinetochore assembly (GO:0051382)3.14677409
18DNA ligation (GO:0006266)3.09537930
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.06004069
20DNA replication checkpoint (GO:0000076)3.01369275
21negative regulation of DNA recombination (GO:0045910)2.99444939
22kinetochore organization (GO:0051383)2.95863131
23replication fork processing (GO:0031297)2.92387661
24synapsis (GO:0007129)2.91546960
25respiratory chain complex IV assembly (GO:0008535)2.89716731
26histone exchange (GO:0043486)2.89418850
27spindle checkpoint (GO:0031577)2.89031951
28establishment of integrated proviral latency (GO:0075713)2.87446060
29regulation of nuclear cell cycle DNA replication (GO:0033262)2.79754157
30mitochondrial respiratory chain complex I assembly (GO:0032981)2.77154949
31NADH dehydrogenase complex assembly (GO:0010257)2.77154949
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77154949
33telomere maintenance via telomerase (GO:0007004)2.75981515
34DNA catabolic process, exonucleolytic (GO:0000738)2.74495811
35double-strand break repair via nonhomologous end joining (GO:0006303)2.72722481
36non-recombinational repair (GO:0000726)2.72722481
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70852224
38regulation of mitotic spindle checkpoint (GO:1903504)2.70852224
39regulation of centriole replication (GO:0046599)2.69982028
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68961582
41protein complex biogenesis (GO:0070271)2.67008688
42regulation of telomere maintenance (GO:0032204)2.66964089
43mitochondrial respiratory chain complex assembly (GO:0033108)2.66768790
44mitotic spindle checkpoint (GO:0071174)2.65379839
45nucleobase catabolic process (GO:0046113)2.64592502
46protein K6-linked ubiquitination (GO:0085020)2.63615954
47lysine metabolic process (GO:0006553)2.62458316
48lysine catabolic process (GO:0006554)2.62458316
49DNA replication-dependent nucleosome assembly (GO:0006335)2.62297858
50DNA replication-dependent nucleosome organization (GO:0034723)2.62297858
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61426235
52tRNA aminoacylation for protein translation (GO:0006418)2.60803057
53mitotic metaphase plate congression (GO:0007080)2.59789988
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58414487
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57906669
56centriole replication (GO:0007099)2.56602479
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.53745790
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.53621633
59DNA replication-independent nucleosome assembly (GO:0006336)2.52786102
60DNA replication-independent nucleosome organization (GO:0034724)2.52786102
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.52754564
62amino acid activation (GO:0043038)2.52700569
63tRNA aminoacylation (GO:0043039)2.52700569
64IMP biosynthetic process (GO:0006188)2.52608558
65acrosome assembly (GO:0001675)2.51841652
66histone H2A acetylation (GO:0043968)2.51620391
67microtubule depolymerization (GO:0007019)2.51460800
68attachment of spindle microtubules to kinetochore (GO:0008608)2.48767936
69somatic hypermutation of immunoglobulin genes (GO:0016446)2.48739166
70somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48739166
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47097324
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47097324
73protein localization to chromosome, centromeric region (GO:0071459)2.46958367
74branched-chain amino acid catabolic process (GO:0009083)2.46442600
75rRNA methylation (GO:0031167)2.45738261
76telomere maintenance via semi-conservative replication (GO:0032201)2.42543216
77regulation of meiosis I (GO:0060631)2.41929664
78cytochrome complex assembly (GO:0017004)2.41792624
79protein localization to chromosome (GO:0034502)2.40808210
80rRNA modification (GO:0000154)2.39380320
81water-soluble vitamin biosynthetic process (GO:0042364)2.38548380
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.37810042
83metaphase plate congression (GO:0051310)2.36666709
84regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.36136050
85regulation of DNA endoreduplication (GO:0032875)2.35590533
86prenylation (GO:0097354)2.34983941
87protein prenylation (GO:0018342)2.34983941
88regulation of cilium movement (GO:0003352)2.34708386
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.34452492
90histone mRNA metabolic process (GO:0008334)2.31389592
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.29577426
92mitotic sister chromatid cohesion (GO:0007064)2.28312966
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.27469078
94negative regulation of sister chromatid segregation (GO:0033046)2.27469078
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.27469078
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.27469078
97negative regulation of mitotic sister chromatid segregation (GO:0033048)2.27469078
98retinal ganglion cell axon guidance (GO:0031290)2.26777450
99aspartate family amino acid catabolic process (GO:0009068)2.26676959
100telomere maintenance via telomere lengthening (GO:0010833)2.26599824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89960914
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56443253
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.06086010
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.90075364
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.87923696
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81889905
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65312606
8IGF1R_20145208_ChIP-Seq_DFB_Human2.54820249
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53665232
10E2F7_22180533_ChIP-Seq_HELA_Human2.49286820
11ZNF274_21170338_ChIP-Seq_K562_Hela2.47207121
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46019151
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42536967
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41498914
15ELK1_19687146_ChIP-ChIP_HELA_Human2.37413594
16FUS_26573619_Chip-Seq_HEK293_Human2.25906275
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25452985
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14538016
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09851165
20VDR_22108803_ChIP-Seq_LS180_Human2.06930529
21EWS_26573619_Chip-Seq_HEK293_Human2.06272556
22TAF15_26573619_Chip-Seq_HEK293_Human2.03422921
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01665919
24GBX2_23144817_ChIP-Seq_PC3_Human2.00668807
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99055813
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96013567
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.92350531
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89700816
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87447963
30VDR_23849224_ChIP-Seq_CD4+_Human1.82901676
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80059444
32P300_19829295_ChIP-Seq_ESCs_Human1.75419757
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73779651
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67629966
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64661463
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64420091
37FOXP3_21729870_ChIP-Seq_TREG_Human1.63455325
38AR_21909140_ChIP-Seq_LNCAP_Human1.54885473
39MYC_18940864_ChIP-ChIP_HL60_Human1.54197258
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49640872
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44768730
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43251862
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.42543242
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.42022519
45GABP_19822575_ChIP-Seq_HepG2_Human1.42014781
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40174530
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38947290
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.37272674
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36380782
50DCP1A_22483619_ChIP-Seq_HELA_Human1.35351072
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35264399
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.32324922
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32247883
54IRF1_19129219_ChIP-ChIP_H3396_Human1.28666045
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28042989
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27006511
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25828957
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23648510
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23341756
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21201807
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19035813
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18824687
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.16935211
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16771285
65TTF2_22483619_ChIP-Seq_HELA_Human1.16293982
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15753673
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14031584
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13460756
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12394629
70SMAD4_21799915_ChIP-Seq_A2780_Human1.12298295
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11650979
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.11094850
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.11038626
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.08528596
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08379117
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08301111
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08061535
78HTT_18923047_ChIP-ChIP_STHdh_Human1.07686868
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.07600172
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06755465
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05874333
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05060992
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05002974
84BCAT_22108803_ChIP-Seq_LS180_Human1.04559264
85RNF2_27304074_Chip-Seq_NSC_Mouse1.03897004
86AR_25329375_ChIP-Seq_VCAP_Human0.99990747
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98986996
88TP53_22573176_ChIP-Seq_HFKS_Human0.98759523
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.98689725
90E2F1_21310950_ChIP-Seq_MCF-7_Human0.96237136
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95906603
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95708353
93KDM5A_27292631_Chip-Seq_BREAST_Human0.95280395
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94632964
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.94302422
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93896116
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93581336
98ER_23166858_ChIP-Seq_MCF-7_Human0.93372025
99NANOG_19829295_ChIP-Seq_ESCs_Human0.93264375
100SOX2_19829295_ChIP-Seq_ESCs_Human0.93264375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.07063955
2MP0008877_abnormal_DNA_methylation3.01919162
3MP0001529_abnormal_vocalization2.56816035
4MP0003890_abnormal_embryonic-extraembry2.50023006
5MP0003880_abnormal_central_pattern2.43870537
6MP0008057_abnormal_DNA_replication2.35873293
7MP0010094_abnormal_chromosome_stability2.28836856
8MP0005084_abnormal_gallbladder_morpholo2.26276834
9MP0002102_abnormal_ear_morphology2.25127139
10MP0006276_abnormal_autonomic_nervous2.15690149
11MP0003693_abnormal_embryo_hatching2.14744224
12MP0003787_abnormal_imprinting2.03749740
13MP0003121_genomic_imprinting2.02630997
14MP0003011_delayed_dark_adaptation2.02340988
15MP0003122_maternal_imprinting1.99360324
16MP0003195_calcinosis1.91817280
17MP0003718_maternal_effect1.79972500
18MP0005394_taste/olfaction_phenotype1.74454593
19MP0005499_abnormal_olfactory_system1.74454593
20MP0003111_abnormal_nucleus_morphology1.73857687
21MP0002736_abnormal_nociception_after1.73083546
22MP0004957_abnormal_blastocyst_morpholog1.70782507
23MP0006072_abnormal_retinal_apoptosis1.69866355
24MP0006054_spinal_hemorrhage1.69612152
25MP0000516_abnormal_urinary_system1.69521490
26MP0005367_renal/urinary_system_phenotyp1.69521490
27MP0003119_abnormal_digestive_system1.67148409
28MP0006292_abnormal_olfactory_placode1.64620522
29MP0008789_abnormal_olfactory_epithelium1.61298638
30MP0003077_abnormal_cell_cycle1.61188318
31MP0006035_abnormal_mitochondrial_morpho1.56773799
32MP0005253_abnormal_eye_physiology1.48740718
33MP0002938_white_spotting1.48120022
34MP0008932_abnormal_embryonic_tissue1.45589009
35MP0002638_abnormal_pupillary_reflex1.42210641
36MP0003786_premature_aging1.38788363
37MP0003937_abnormal_limbs/digits/tail_de1.32077066
38MP0001984_abnormal_olfaction1.31413876
39MP0001188_hyperpigmentation1.30727085
40MP0001486_abnormal_startle_reflex1.28822383
41MP0002163_abnormal_gland_morphology1.25788771
42MP0005551_abnormal_eye_electrophysiolog1.25073316
43MP0002233_abnormal_nose_morphology1.21978547
44MP0001929_abnormal_gametogenesis1.19830499
45MP0009697_abnormal_copulation1.19669509
46MP0000049_abnormal_middle_ear1.17889384
47MP0002210_abnormal_sex_determination1.17257316
48MP0000372_irregular_coat_pigmentation1.15531530
49MP0000778_abnormal_nervous_system1.14422442
50MP0001293_anophthalmia1.14088356
51MP0004215_abnormal_myocardial_fiber1.12545253
52MP0006036_abnormal_mitochondrial_physio1.12125236
53MP0001986_abnormal_taste_sensitivity1.10264388
54MP0008995_early_reproductive_senescence1.07664375
55MP0009046_muscle_twitch1.07276924
56MP0001764_abnormal_homeostasis1.06331840
57MP0002272_abnormal_nervous_system1.04159234
58MP0002751_abnormal_autonomic_nervous1.02984944
59MP0008775_abnormal_heart_ventricle1.02182037
60MP0000631_abnormal_neuroendocrine_gland1.01970371
61MP0008007_abnormal_cellular_replicative1.01144229
62MP0000653_abnormal_sex_gland0.99653110
63MP0003755_abnormal_palate_morphology0.98751711
64MP0002234_abnormal_pharynx_morphology0.98462763
65MP0002084_abnormal_developmental_patter0.98092863
66MP0001968_abnormal_touch/_nociception0.97942066
67MP0004197_abnormal_fetal_growth/weight/0.97602570
68MP0004133_heterotaxia0.97578564
69MP0003385_abnormal_body_wall0.96130671
70MP0001145_abnormal_male_reproductive0.93382375
71MP0002160_abnormal_reproductive_system0.93046795
72MP0005423_abnormal_somatic_nervous0.89917139
73MP0004043_abnormal_pH_regulation0.89580028
74MP0001286_abnormal_eye_development0.87328785
75MP0003698_abnormal_male_reproductive0.87173480
76MP0003186_abnormal_redox_activity0.86255893
77MP0004270_analgesia0.86197115
78MP0004147_increased_porphyrin_level0.85567038
79MP0002184_abnormal_innervation0.85234274
80MP0001697_abnormal_embryo_size0.84606095
81MP0001299_abnormal_eye_distance/0.84530091
82MP0003861_abnormal_nervous_system0.83766611
83MP0001730_embryonic_growth_arrest0.83652525
84MP0005623_abnormal_meninges_morphology0.83612645
85MP0003935_abnormal_craniofacial_develop0.82595335
86MP0004142_abnormal_muscle_tone0.82033772
87MP0005391_vision/eye_phenotype0.82022708
88MP0003123_paternal_imprinting0.81574917
89MP0004924_abnormal_behavior0.79355439
90MP0005386_behavior/neurological_phenoty0.79355439
91MP0005187_abnormal_penis_morphology0.79187708
92MP0005380_embryogenesis_phenotype0.79125587
93MP0001672_abnormal_embryogenesis/_devel0.79125587
94MP0003221_abnormal_cardiomyocyte_apopto0.77750266
95MP0002085_abnormal_embryonic_tissue0.77597913
96MP0003567_abnormal_fetal_cardiomyocyte0.77567043
97MP0002090_abnormal_vision0.77540185
98MP0002557_abnormal_social/conspecific_i0.77366398
99MP0000358_abnormal_cell_content/0.77060000
100MP0003136_yellow_coat_color0.77001981

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.74374927
2Volvulus (HP:0002580)3.14188995
3Hepatoblastoma (HP:0002884)3.13747389
4Acute encephalopathy (HP:0006846)2.79976796
5Acute necrotizing encephalopathy (HP:0006965)2.74271559
6Increased serum pyruvate (HP:0003542)2.72994452
7Abnormal lung lobation (HP:0002101)2.72767704
8Medial flaring of the eyebrow (HP:0010747)2.71644154
9Abnormality of glycolysis (HP:0004366)2.63542409
10Labial hypoplasia (HP:0000066)2.63431974
11Hypoplastic female external genitalia (HP:0012815)2.59993457
12Short 1st metacarpal (HP:0010034)2.58522321
13Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.58522321
14Chromsome breakage (HP:0040012)2.55937693
15Abnormality of chromosome stability (HP:0003220)2.54873014
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.43702331
17Colon cancer (HP:0003003)2.41886742
18Gait imbalance (HP:0002141)2.40802846
19Hypoplastic pelvis (HP:0008839)2.37218284
20Bifid tongue (HP:0010297)2.36984053
21Progressive macrocephaly (HP:0004481)2.36204887
22Abnormal mitochondria in muscle tissue (HP:0008316)2.35286252
23Congenital primary aphakia (HP:0007707)2.35032594
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34359359
25Meckel diverticulum (HP:0002245)2.31977172
26Abnormality of the ileum (HP:0001549)2.28330256
27Pancreatic fibrosis (HP:0100732)2.24815606
28Abnormality of the 1st metacarpal (HP:0010009)2.23965085
29Genital tract atresia (HP:0001827)2.22923818
30Abnormal hair whorl (HP:0010721)2.22819891
31Neoplasm of the adrenal gland (HP:0100631)2.21683720
32Oligodactyly (hands) (HP:0001180)2.18191365
33Vaginal atresia (HP:0000148)2.18111876
34Retinal dysplasia (HP:0007973)2.18099457
35Embryonal renal neoplasm (HP:0011794)2.15212172
36Cortical dysplasia (HP:0002539)2.13470865
37Pancreatic cysts (HP:0001737)2.13421580
38Long clavicles (HP:0000890)2.12855958
39Cerebral edema (HP:0002181)2.11131227
40Short tibia (HP:0005736)2.10472113
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.10446438
42Nephrogenic diabetes insipidus (HP:0009806)2.10171974
43Intestinal atresia (HP:0011100)2.09985311
44Abnormality of the metopic suture (HP:0005556)2.08966595
45Abnormality of the labia (HP:0000058)2.08907379
46Increased CSF lactate (HP:0002490)2.07266394
47Polyphagia (HP:0002591)2.05564319
48Methylmalonic acidemia (HP:0002912)2.04021471
49Abnormality of the preputium (HP:0100587)2.03251334
50Mitochondrial inheritance (HP:0001427)2.02240616
51Hyperglycinemia (HP:0002154)2.02112422
52Gonadotropin excess (HP:0000837)2.01632222
53True hermaphroditism (HP:0010459)1.99115995
54Poor suck (HP:0002033)1.96417475
55Abnormality of the duodenum (HP:0002246)1.95399718
56Small intestinal stenosis (HP:0012848)1.94810605
57Duodenal stenosis (HP:0100867)1.94810605
58CNS hypomyelination (HP:0003429)1.92954640
59Hepatic necrosis (HP:0002605)1.92588086
60Neoplasm of the adrenal cortex (HP:0100641)1.92578815
61Hypoplastic labia majora (HP:0000059)1.91318103
62Hypoglycemic coma (HP:0001325)1.90623009
63Hepatocellular necrosis (HP:0001404)1.89233793
64Glioma (HP:0009733)1.88860062
65Amyotrophic lateral sclerosis (HP:0007354)1.88662400
66Papillary thyroid carcinoma (HP:0002895)1.88422404
67Pancreatic islet-cell hyperplasia (HP:0004510)1.88021583
68Supernumerary spleens (HP:0009799)1.86072877
69Hyperinsulinemic hypoglycemia (HP:0000825)1.85041344
70Astrocytoma (HP:0009592)1.85000426
71Abnormality of the astrocytes (HP:0100707)1.85000426
72Aplasia/Hypoplasia of the sternum (HP:0006714)1.84695412
73Lissencephaly (HP:0001339)1.84578446
74Molar tooth sign on MRI (HP:0002419)1.84384399
75Abnormality of midbrain morphology (HP:0002418)1.84384399
76Postaxial hand polydactyly (HP:0001162)1.84227741
77Nephroblastoma (Wilms tumor) (HP:0002667)1.82689492
78Nephronophthisis (HP:0000090)1.81344493
79Horseshoe kidney (HP:0000085)1.81123689
80Sloping forehead (HP:0000340)1.80708943
81Medulloblastoma (HP:0002885)1.79519902
82Ependymoma (HP:0002888)1.76616467
83Adrenal hypoplasia (HP:0000835)1.74630161
84Poor coordination (HP:0002370)1.73122519
85Absent radius (HP:0003974)1.71819294
86Preaxial hand polydactyly (HP:0001177)1.71737115
87Postnatal microcephaly (HP:0005484)1.71324567
88Stenosis of the external auditory canal (HP:0000402)1.70353897
89Sclerocornea (HP:0000647)1.69929403
90Tubulointerstitial nephritis (HP:0001970)1.69600005
91Rhabdomyosarcoma (HP:0002859)1.69317120
92Hypothermia (HP:0002045)1.69310417
93Hyperglycinuria (HP:0003108)1.69030898
94Aplasia involving forearm bones (HP:0009822)1.68548493
95Absent forearm bone (HP:0003953)1.68548493
96Hypoglycemic seizures (HP:0002173)1.68452459
97Abnormality of the labia majora (HP:0012881)1.68375029
98Prominent metopic ridge (HP:0005487)1.67089800
99Decreased lacrimation (HP:0000633)1.66547956
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.66015672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.62214557
2MAP3K43.30494554
3MAP4K22.88548725
4TNIK2.77970049
5NEK12.58265455
6SRPK12.54342439
7WNK32.53964099
8PLK42.42930838
9EIF2AK12.32598032
10TSSK62.31979719
11BCR2.25777068
12BMPR1B2.22486045
13EIF2AK32.18145950
14MKNK22.08883315
15MAPK131.92529168
16BUB11.90856795
17ACVR1B1.90554231
18PLK31.87892521
19BRSK21.84914948
20NUAK11.82260853
21ERBB31.73013713
22CASK1.72224587
23TTK1.70264099
24MAP2K71.63482511
25MKNK11.61889030
26ZAK1.60681768
27WEE11.58307255
28CSNK1G21.56314183
29CSNK1G31.53916342
30CSNK1G11.48679370
31EPHA41.41379062
32MARK11.36462922
33PLK11.31269708
34FRK1.28518684
35CDC71.23530022
36PDK21.21170139
37CSNK1A1L1.21055013
38SIK31.18869303
39STK161.18362851
40PAK31.18199070
41PLK21.13509856
42PBK1.13337650
43BRSK11.11353651
44PNCK1.10844017
45DYRK21.10827153
46PINK11.07779104
47NME11.07143706
48VRK11.05102262
49MST40.94995117
50ATR0.88543959
51TGFBR10.82392657
52MINK10.82005033
53AKT30.77727946
54VRK20.77283027
55FER0.73324921
56KSR10.73013930
57BRD40.72395726
58CLK10.71037359
59PRKCG0.69586085
60NEK20.66182196
61CCNB10.64610807
62STK38L0.63074382
63ATM0.62918622
64BCKDK0.62868198
65RAF10.62255878
66YES10.58388448
67EIF2AK20.57892912
68PAK60.55014391
69INSRR0.53444709
70PKN10.53271627
71PHKG20.50051215
72PHKG10.50051215
73TESK10.49446377
74SCYL20.48568881
75CHEK20.47221483
76NTRK20.46193235
77PRKCE0.45807208
78AURKB0.45082669
79CDK30.44760457
80TIE10.44573022
81GRK10.42131518
82CSNK2A10.40879158
83PASK0.40570381
84CDK80.39726070
85ERBB40.38910539
86CHEK10.38543867
87UHMK10.38077129
88STK240.36567265
89NLK0.36149463
90CSNK1E0.36075588
91PRKDC0.35991575
92CDK180.34154325
93DYRK30.32281919
94CSNK1D0.32150309
95FLT30.31949663
96STK30.31874031
97CAMK2A0.30574802
98CDK10.30541383
99DYRK1A0.30474971
100CSNK1A10.29976866

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33828486
2Non-homologous end-joining_Homo sapiens_hsa034502.89626170
3Proteasome_Homo sapiens_hsa030502.89117911
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.59899994
5Steroid biosynthesis_Homo sapiens_hsa001002.59384380
6Propanoate metabolism_Homo sapiens_hsa006402.54618631
7Protein export_Homo sapiens_hsa030602.47935825
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30646398
9Mismatch repair_Homo sapiens_hsa034302.19681367
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16821409
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13790963
12Fanconi anemia pathway_Homo sapiens_hsa034602.10347215
13Basal transcription factors_Homo sapiens_hsa030222.01792688
14Butanoate metabolism_Homo sapiens_hsa006501.86617002
15Oxidative phosphorylation_Homo sapiens_hsa001901.80811692
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79763240
17Homologous recombination_Homo sapiens_hsa034401.78270707
18Fatty acid elongation_Homo sapiens_hsa000621.76756463
19DNA replication_Homo sapiens_hsa030301.74529617
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70996707
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62728102
22RNA degradation_Homo sapiens_hsa030181.61288235
23Nucleotide excision repair_Homo sapiens_hsa034201.60906107
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.60425440
25RNA transport_Homo sapiens_hsa030131.59104473
26Base excision repair_Homo sapiens_hsa034101.58296838
27Pyruvate metabolism_Homo sapiens_hsa006201.55473985
28Parkinsons disease_Homo sapiens_hsa050121.55154855
29RNA polymerase_Homo sapiens_hsa030201.52789126
30Nicotine addiction_Homo sapiens_hsa050331.45573106
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41593601
32Vitamin B6 metabolism_Homo sapiens_hsa007501.40432506
33Cell cycle_Homo sapiens_hsa041101.37553042
34Spliceosome_Homo sapiens_hsa030401.33530738
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29897264
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19686464
37Peroxisome_Homo sapiens_hsa041461.19432128
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14343335
39Fatty acid metabolism_Homo sapiens_hsa012121.12950670
40Huntingtons disease_Homo sapiens_hsa050161.08398629
41Selenocompound metabolism_Homo sapiens_hsa004501.08085806
42Oocyte meiosis_Homo sapiens_hsa041141.07294413
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06947125
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.05289822
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05112176
46Pyrimidine metabolism_Homo sapiens_hsa002401.02881688
47mRNA surveillance pathway_Homo sapiens_hsa030150.99820454
48One carbon pool by folate_Homo sapiens_hsa006700.97220101
49Phototransduction_Homo sapiens_hsa047440.94235623
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92256616
51Collecting duct acid secretion_Homo sapiens_hsa049660.90596330
52Purine metabolism_Homo sapiens_hsa002300.89846509
53Hedgehog signaling pathway_Homo sapiens_hsa043400.89364554
54Fatty acid degradation_Homo sapiens_hsa000710.89064825
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.88371711
56beta-Alanine metabolism_Homo sapiens_hsa004100.86131129
57Circadian rhythm_Homo sapiens_hsa047100.82596793
58Carbon metabolism_Homo sapiens_hsa012000.82344656
59Alzheimers disease_Homo sapiens_hsa050100.80274050
60Metabolic pathways_Homo sapiens_hsa011000.74289810
61Glutathione metabolism_Homo sapiens_hsa004800.73538653
62Nitrogen metabolism_Homo sapiens_hsa009100.73345491
63Regulation of autophagy_Homo sapiens_hsa041400.71143283
64Taste transduction_Homo sapiens_hsa047420.69127945
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68813600
66Basal cell carcinoma_Homo sapiens_hsa052170.64053297
67Arginine and proline metabolism_Homo sapiens_hsa003300.63946065
68Biosynthesis of amino acids_Homo sapiens_hsa012300.63903454
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63717054
70Tryptophan metabolism_Homo sapiens_hsa003800.63645610
71p53 signaling pathway_Homo sapiens_hsa041150.62121940
72N-Glycan biosynthesis_Homo sapiens_hsa005100.61059387
73Wnt signaling pathway_Homo sapiens_hsa043100.59030075
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57459148
75Folate biosynthesis_Homo sapiens_hsa007900.57294988
76Sulfur metabolism_Homo sapiens_hsa009200.57016365
77Synaptic vesicle cycle_Homo sapiens_hsa047210.56857185
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53375674
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53318422
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50677808
81Hippo signaling pathway_Homo sapiens_hsa043900.50580464
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47834571
83Lysine degradation_Homo sapiens_hsa003100.47059240
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45921266
85GABAergic synapse_Homo sapiens_hsa047270.44652348
86Fat digestion and absorption_Homo sapiens_hsa049750.44528274
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44505556
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43611802
89Vibrio cholerae infection_Homo sapiens_hsa051100.42955702
90Caffeine metabolism_Homo sapiens_hsa002320.42284455
91TGF-beta signaling pathway_Homo sapiens_hsa043500.41171142
92Retinol metabolism_Homo sapiens_hsa008300.41140635
93Olfactory transduction_Homo sapiens_hsa047400.39703205
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37602381
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35259810
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35043281
97Dopaminergic synapse_Homo sapiens_hsa047280.31164002
98Ether lipid metabolism_Homo sapiens_hsa005650.30295778
99Cardiac muscle contraction_Homo sapiens_hsa042600.27811031
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26599491

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