ZNF300

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.12222499
2presynaptic membrane assembly (GO:0097105)4.90753569
3neuron cell-cell adhesion (GO:0007158)4.83974257
4nucleobase catabolic process (GO:0046113)4.77867001
5gamma-aminobutyric acid transport (GO:0015812)4.53422560
6presynaptic membrane organization (GO:0097090)4.22748714
7cell migration in hindbrain (GO:0021535)3.76572519
8head development (GO:0060322)3.63071333
9establishment of mitochondrion localization (GO:0051654)3.61269916
10postsynaptic membrane organization (GO:0001941)3.58052587
11negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.53745129
12vocalization behavior (GO:0071625)3.53449449
13limb bud formation (GO:0060174)3.52061071
14axonal fasciculation (GO:0007413)3.44964623
15neuron recognition (GO:0008038)3.44430232
16regulation of development, heterochronic (GO:0040034)3.38428369
17DNA double-strand break processing (GO:0000729)3.34628600
18central nervous system projection neuron axonogenesis (GO:0021952)3.31839607
19negative regulation of oligodendrocyte differentiation (GO:0048715)3.30110753
20protein localization to synapse (GO:0035418)3.29921455
21negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29874278
22neural tube formation (GO:0001841)3.27543646
23auditory behavior (GO:0031223)3.25204586
24calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.23360097
25olfactory bulb development (GO:0021772)3.22751699
26hippocampus development (GO:0021766)3.22191388
27neurotransmitter-gated ion channel clustering (GO:0072578)3.21458994
28positive regulation of mitochondrial fission (GO:0090141)3.13156073
29cerebral cortex radially oriented cell migration (GO:0021799)3.10158240
30synapse assembly (GO:0007416)3.06133505
31forebrain neuron differentiation (GO:0021879)3.02429290
32DNA integration (GO:0015074)2.99904059
33response to pheromone (GO:0019236)2.99154665
34sequestering of actin monomers (GO:0042989)2.96922525
35behavioral response to nicotine (GO:0035095)2.94524002
36retinal ganglion cell axon guidance (GO:0031290)2.90747295
37glycosphingolipid biosynthetic process (GO:0006688)2.87086441
38somite rostral/caudal axis specification (GO:0032525)2.86963594
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86046914
40histone H2A acetylation (GO:0043968)2.85514419
41intraciliary transport (GO:0042073)2.78998443
42DNA damage response, detection of DNA damage (GO:0042769)2.77805117
43spinal cord development (GO:0021510)2.76465625
44nonmotile primary cilium assembly (GO:0035058)2.71315849
45mechanosensory behavior (GO:0007638)2.71246989
46cerebral cortex cell migration (GO:0021795)2.70664454
47positive regulation of synapse assembly (GO:0051965)2.70355802
48regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.69643488
49somite development (GO:0061053)2.69226330
50central nervous system neuron axonogenesis (GO:0021955)2.68539307
51protein polyglutamylation (GO:0018095)2.64953974
52dendrite morphogenesis (GO:0048813)2.64892877
53sympathetic nervous system development (GO:0048485)2.62964030
54negative regulation of DNA recombination (GO:0045910)2.60319679
55negative regulation of glial cell differentiation (GO:0045686)2.57845434
56seminiferous tubule development (GO:0072520)2.56602914
57somatic hypermutation of immunoglobulin genes (GO:0016446)2.56284618
58somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56284618
59pyrimidine dimer repair (GO:0006290)2.55988483
60ubiquinone metabolic process (GO:0006743)2.53268327
61positive regulation of dendritic spine morphogenesis (GO:0061003)2.52720987
62proximal/distal pattern formation (GO:0009954)2.52312971
63cell proliferation in forebrain (GO:0021846)2.51649958
64dendritic spine morphogenesis (GO:0060997)2.51624256
65regulation of oligodendrocyte differentiation (GO:0048713)2.51324900
66positive regulation of amino acid transport (GO:0051957)2.51177965
67regulation of timing of cell differentiation (GO:0048505)2.50887308
68microtubule depolymerization (GO:0007019)2.50138644
69ionotropic glutamate receptor signaling pathway (GO:0035235)2.49745246
70regulation of feeding behavior (GO:0060259)2.49280705
71mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.47439058
72positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.47439058
73protein localization to cilium (GO:0061512)2.46183352
74spermatid nucleus differentiation (GO:0007289)2.46044051
75epithelial cell differentiation involved in kidney development (GO:0035850)2.44870695
76cullin deneddylation (GO:0010388)2.43532363
77cilium morphogenesis (GO:0060271)2.42010266
78response to auditory stimulus (GO:0010996)2.41236524
79retinal cone cell development (GO:0046549)2.37644857
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.36143922
81regulation of translation, ncRNA-mediated (GO:0045974)2.36143922
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36143922
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35865433
84mRNA splice site selection (GO:0006376)2.35392423
85regulation of collateral sprouting (GO:0048670)2.34216595
86homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.34118742
87transmission of nerve impulse (GO:0019226)2.33313327
88epithelial cilium movement (GO:0003351)2.33102243
89regulation of synapse assembly (GO:0051963)2.32243537
90mitochondrion transport along microtubule (GO:0047497)2.30614223
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.30614223
92glutamate receptor signaling pathway (GO:0007215)2.29795546
93negative regulation of astrocyte differentiation (GO:0048712)2.29102380
94neuron migration (GO:0001764)2.28935630
95regulation of mRNA splicing, via spliceosome (GO:0048024)2.28150816
96protein-cofactor linkage (GO:0018065)2.27799908
97synapse organization (GO:0050808)2.27426802
98behavioral response to ethanol (GO:0048149)2.26691502
99hindbrain development (GO:0030902)2.26151818
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.25682353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.69470387
2GBX2_23144817_ChIP-Seq_PC3_Human3.38580061
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09752443
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.07686546
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.07065397
6* ZNF274_21170338_ChIP-Seq_K562_Hela2.95488862
7IGF1R_20145208_ChIP-Seq_DFB_Human2.92487679
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54052669
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52923403
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48125220
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42817127
12TAF15_26573619_Chip-Seq_HEK293_Human2.41763165
13FUS_26573619_Chip-Seq_HEK293_Human2.34379739
14EWS_26573619_Chip-Seq_HEK293_Human2.27726147
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24129011
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18363322
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.08174744
18VDR_22108803_ChIP-Seq_LS180_Human2.02113542
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01660635
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00683964
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97148973
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89914845
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87748887
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85825843
25P300_19829295_ChIP-Seq_ESCs_Human1.84946191
26RNF2_27304074_Chip-Seq_NSC_Mouse1.81112759
27* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69644261
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.69022351
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.59510072
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59337075
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56554211
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56282280
33REST_21632747_ChIP-Seq_MESCs_Mouse1.51505442
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50673766
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50098342
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.48891791
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46432317
38IRF1_19129219_ChIP-ChIP_H3396_Human1.44721892
39* SOX2_16153702_ChIP-ChIP_HESCs_Human1.44001655
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.42310896
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.42226837
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41644145
43ELK1_19687146_ChIP-ChIP_HELA_Human1.41089130
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.40776459
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40242736
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39996250
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38406186
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38322765
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38061022
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37752484
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36117169
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35855440
53CBP_20019798_ChIP-Seq_JUKART_Human1.35855440
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31727578
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.30638739
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.29313041
57MYC_18940864_ChIP-ChIP_HL60_Human1.28010073
58AR_21572438_ChIP-Seq_LNCaP_Human1.26660205
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26449850
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26449850
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24472325
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24254085
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22781011
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.21747839
65STAT3_23295773_ChIP-Seq_U87_Human1.20587011
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17024879
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16083149
68AR_25329375_ChIP-Seq_VCAP_Human1.14885255
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14757269
70SOX9_26525672_Chip-Seq_HEART_Mouse1.13987546
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12280464
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12167210
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10921582
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10365535
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09592511
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.09587608
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09107121
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07566389
79ER_23166858_ChIP-Seq_MCF-7_Human1.07187708
80RUNX2_22187159_ChIP-Seq_PCA_Human1.07131805
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06765310
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04915086
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04602843
84* NANOG_16153702_ChIP-ChIP_HESCs_Human1.00929992
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00606548
86JUN_21703547_ChIP-Seq_K562_Human1.00010104
87NANOG_18555785_Chip-Seq_ESCs_Mouse0.99717978
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99633843
89SOX2_21211035_ChIP-Seq_LN229_Gbm0.99304187
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99100735
91TAL1_26923725_Chip-Seq_HPCs_Mouse0.99060808
92* TCF4_23295773_ChIP-Seq_U87_Human0.97771778
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96329953
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95088905
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94016463
96WT1_19549856_ChIP-ChIP_CCG9911_Human0.93892938
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.93364909
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91877806
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90651479
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.89557618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.80480271
2MP0000778_abnormal_nervous_system2.65838209
3MP0001529_abnormal_vocalization2.63954294
4MP0002102_abnormal_ear_morphology2.57341449
5MP0002822_catalepsy2.54280982
6MP0004270_analgesia2.35215211
7MP0006292_abnormal_olfactory_placode2.29232096
8MP0000049_abnormal_middle_ear2.26190728
9MP0004859_abnormal_synaptic_plasticity2.20774186
10MP0003122_maternal_imprinting2.16691826
11MP0003890_abnormal_embryonic-extraembry2.11528297
12MP0005394_taste/olfaction_phenotype2.08035470
13MP0005499_abnormal_olfactory_system2.08035470
14MP0003121_genomic_imprinting2.03415824
15MP0008789_abnormal_olfactory_epithelium1.99085717
16MP0006276_abnormal_autonomic_nervous1.98845109
17MP0008877_abnormal_DNA_methylation1.98055597
18MP0004133_heterotaxia1.90765988
19MP0002735_abnormal_chemical_nociception1.78793203
20MP0002751_abnormal_autonomic_nervous1.75935000
21MP0001984_abnormal_olfaction1.75635993
22MP0008058_abnormal_DNA_repair1.73846428
23MP0003635_abnormal_synaptic_transmissio1.71694797
24MP0003787_abnormal_imprinting1.67200494
25MP0003937_abnormal_limbs/digits/tail_de1.63893635
26MP0005423_abnormal_somatic_nervous1.63108938
27MP0001188_hyperpigmentation1.60276242
28MP0000631_abnormal_neuroendocrine_gland1.56224981
29MP0002184_abnormal_innervation1.52827425
30MP0001968_abnormal_touch/_nociception1.50799393
31MP0002736_abnormal_nociception_after1.49560457
32MP0002234_abnormal_pharynx_morphology1.48610873
33MP0001293_anophthalmia1.45042899
34MP0002734_abnormal_mechanical_nocicepti1.44838726
35MP0004811_abnormal_neuron_physiology1.44676934
36MP0000955_abnormal_spinal_cord1.41296372
37MP0002233_abnormal_nose_morphology1.41028084
38MP0003861_abnormal_nervous_system1.40320584
39MP0005187_abnormal_penis_morphology1.40115083
40MP0002272_abnormal_nervous_system1.39142799
41MP0003567_abnormal_fetal_cardiomyocyte1.38496763
42MP0002063_abnormal_learning/memory/cond1.38186645
43MP0006072_abnormal_retinal_apoptosis1.37874273
44MP0009745_abnormal_behavioral_response1.35881659
45MP0003119_abnormal_digestive_system1.35552207
46MP0003938_abnormal_ear_development1.34655228
47MP0003755_abnormal_palate_morphology1.33788696
48MP0002572_abnormal_emotion/affect_behav1.33138609
49MP0004885_abnormal_endolymph1.31089552
50MP0002938_white_spotting1.28869710
51MP0002697_abnormal_eye_size1.27223577
52MP0005551_abnormal_eye_electrophysiolog1.26976441
53MP0002557_abnormal_social/conspecific_i1.26885652
54MP0008057_abnormal_DNA_replication1.26400890
55MP0003385_abnormal_body_wall1.25984399
56MP0002638_abnormal_pupillary_reflex1.25919809
57MP0001286_abnormal_eye_development1.25497871
58MP0005253_abnormal_eye_physiology1.23901713
59MP0002882_abnormal_neuron_morphology1.23265174
60MP0001986_abnormal_taste_sensitivity1.22946559
61MP0002752_abnormal_somatic_nervous1.21471563
62MP0004142_abnormal_muscle_tone1.20524512
63MP0002152_abnormal_brain_morphology1.16804671
64MP0001486_abnormal_startle_reflex1.15095662
65MP0001177_atelectasis1.14502861
66MP0009046_muscle_twitch1.14054377
67MP0002653_abnormal_ependyma_morphology1.11251404
68MP0000647_abnormal_sebaceous_gland1.08572713
69MP0000569_abnormal_digit_pigmentation1.05761673
70MP0003935_abnormal_craniofacial_develop1.04704520
71MP0005391_vision/eye_phenotype1.01359545
72MP0003221_abnormal_cardiomyocyte_apopto1.00032380
73MP0002067_abnormal_sensory_capabilities0.99352982
74MP0001299_abnormal_eye_distance/0.98777907
75MP0002064_seizures0.97420070
76MP0004197_abnormal_fetal_growth/weight/0.97355405
77MP0008995_early_reproductive_senescence0.97178414
78MP0005248_abnormal_Harderian_gland0.96948171
79MP0008932_abnormal_embryonic_tissue0.95307453
80MP0002081_perinatal_lethality0.94635678
81MP0005645_abnormal_hypothalamus_physiol0.94146685
82MP0010094_abnormal_chromosome_stability0.91470258
83MP0000026_abnormal_inner_ear0.91009666
84MP0005195_abnormal_posterior_eye0.90851518
85MP0005386_behavior/neurological_phenoty0.90536786
86MP0004924_abnormal_behavior0.90536786
87MP0003693_abnormal_embryo_hatching0.88310799
88MP0004742_abnormal_vestibular_system0.84213183
89MP0001270_distended_abdomen0.83450340
90MP0003115_abnormal_respiratory_system0.82952166
91MP0001485_abnormal_pinna_reflex0.82117097
92MP0001970_abnormal_pain_threshold0.81573551
93MP0002069_abnormal_eating/drinking_beha0.81351548
94MP0002084_abnormal_developmental_patter0.81326490
95MP0003698_abnormal_male_reproductive0.80469024
96MP0009703_decreased_birth_body0.80464344
97MP0003315_abnormal_perineum_morphology0.79421655
98MP0002066_abnormal_motor_capabilities/c0.78912114
99MP0002116_abnormal_craniofacial_bone0.75472950
100MP0002111_abnormal_tail_morphology0.75387052

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.85559637
2Drooling (HP:0002307)3.26875572
3Abnormality of the labia minora (HP:0012880)3.04801212
4Excessive salivation (HP:0003781)2.94722589
5Lissencephaly (HP:0001339)2.87526802
6Colon cancer (HP:0003003)2.84529665
7Intestinal atresia (HP:0011100)2.77852630
8Progressive inability to walk (HP:0002505)2.73254957
9Absent speech (HP:0001344)2.72536911
10Ependymoma (HP:0002888)2.72178117
11Hyperventilation (HP:0002883)2.69984787
12Limb dystonia (HP:0002451)2.63179276
13Gait imbalance (HP:0002141)2.60998039
14Nephronophthisis (HP:0000090)2.55854784
15Abnormality of the astrocytes (HP:0100707)2.54900821
16Astrocytoma (HP:0009592)2.54900821
17Retinal dysplasia (HP:0007973)2.50265184
18Pendular nystagmus (HP:0012043)2.49621326
19Genital tract atresia (HP:0001827)2.47034453
20Medial flaring of the eyebrow (HP:0010747)2.46719478
21Nephrogenic diabetes insipidus (HP:0009806)2.42419283
22Vaginal atresia (HP:0000148)2.38118383
23Pachygyria (HP:0001302)2.37565233
24Congenital primary aphakia (HP:0007707)2.37536826
25Abnormal lung lobation (HP:0002101)2.33323760
26True hermaphroditism (HP:0010459)2.32831878
27Medulloblastoma (HP:0002885)2.31651196
28Pancreatic cysts (HP:0001737)2.30788998
29Glioma (HP:0009733)2.29614519
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.24431082
31Amyotrophic lateral sclerosis (HP:0007354)2.22906684
32Inability to walk (HP:0002540)2.22048544
33Pancreatic fibrosis (HP:0100732)2.20856794
34Hypsarrhythmia (HP:0002521)2.11911366
35Molar tooth sign on MRI (HP:0002419)2.10381948
36Abnormality of midbrain morphology (HP:0002418)2.10381948
37Septo-optic dysplasia (HP:0100842)2.07939582
38Urinary urgency (HP:0000012)2.07890582
39Micropenis (HP:0000054)2.06754418
40Optic nerve hypoplasia (HP:0000609)2.06528276
41Hepatoblastoma (HP:0002884)2.06184018
42Decreased testicular size (HP:0008734)2.05719733
43Thyroid-stimulating hormone excess (HP:0002925)2.05552214
44Abnormality of the renal medulla (HP:0100957)2.05266019
45Patellar aplasia (HP:0006443)2.04855637
46Broad-based gait (HP:0002136)2.04087299
47Specific learning disability (HP:0001328)2.03622703
48Hyperglycinemia (HP:0002154)2.00690261
49EEG with generalized epileptiform discharges (HP:0011198)2.00093087
50Type II lissencephaly (HP:0007260)1.97711885
51Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96892089
52Hypoplasia of the brainstem (HP:0002365)1.96892089
53Volvulus (HP:0002580)1.95999199
54Cupped ear (HP:0000378)1.95967130
55Renal hypoplasia (HP:0000089)1.95446681
56Cerebellar dysplasia (HP:0007033)1.94663481
57Scrotal hypoplasia (HP:0000046)1.94599289
58Chronic hepatic failure (HP:0100626)1.94289976
59Epileptiform EEG discharges (HP:0011182)1.92697439
60Morphological abnormality of the middle ear (HP:0008609)1.91827379
61Focal motor seizures (HP:0011153)1.90052793
62Hypoplastic pelvis (HP:0008839)1.89612327
63Atonic seizures (HP:0010819)1.89258066
64Abnormality of the lower motor neuron (HP:0002366)1.88923130
65Aplasia/Hypoplasia of the patella (HP:0006498)1.87126347
66Split foot (HP:0001839)1.86489267
67Hemiparesis (HP:0001269)1.86452344
68Postaxial hand polydactyly (HP:0001162)1.85386324
69Failure to thrive in infancy (HP:0001531)1.84420951
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82724074
71Labial hypoplasia (HP:0000066)1.82364458
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.81976442
73Polymicrogyria (HP:0002126)1.80494730
74Absent eyebrow (HP:0002223)1.79791888
75Protruding tongue (HP:0010808)1.77290545
76Polyphagia (HP:0002591)1.76156481
77Narrow forehead (HP:0000341)1.75975007
78Bifid tongue (HP:0010297)1.75889516
79Esotropia (HP:0000565)1.75644841
80Gastrointestinal atresia (HP:0002589)1.74950046
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74515477
82Hypoplastic female external genitalia (HP:0012815)1.73498629
83Oligodactyly (hands) (HP:0001180)1.73354399
84Occipital encephalocele (HP:0002085)1.73153404
85Broad foot (HP:0001769)1.71654876
86Anencephaly (HP:0002323)1.70587903
87Intellectual disability, moderate (HP:0002342)1.70141810
88Spastic tetraplegia (HP:0002510)1.68805161
89Postaxial foot polydactyly (HP:0001830)1.66846588
90Shoulder girdle muscle weakness (HP:0003547)1.66443176
91Short 4th metacarpal (HP:0010044)1.66336901
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66336901
93Absent septum pellucidum (HP:0001331)1.65654576
94Abnormality of the septum pellucidum (HP:0007375)1.64565693
95Impaired vibration sensation in the lower limbs (HP:0002166)1.64477618
96Abnormality of the metopic suture (HP:0005556)1.64038905
97Long clavicles (HP:0000890)1.62675047
98Severe Myopia (HP:0011003)1.62382779
99Focal seizures (HP:0007359)1.61591148
100Anophthalmia (HP:0000528)1.60815651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.58781458
2MARK14.11170962
3CASK3.59428917
4MAP2K73.43987360
5BCR3.39167515
6WNK32.87833907
7SRPK12.52434193
8TRIM282.51147977
9MAPK132.16032149
10DYRK22.12913680
11ERBB32.10666124
12RPS6KA41.85308955
13NTRK21.75686436
14TNIK1.75042956
15DYRK31.71944472
16BRD41.67161968
17MAP2K41.63487851
18CSNK1G21.61891504
19PNCK1.54151804
20MKNK11.48681183
21CSNK1G31.47574470
22CSNK1G11.46537340
23CSNK1A1L1.46325055
24ZAK1.44707249
25MKNK21.32405695
26MAP3K61.28865701
27BMPR1B1.28790148
28CCNB11.23201483
29TSSK61.19512207
30MAP4K21.16595010
31PLK21.13432609
32FRK1.12040594
33PLK31.11779554
34STK38L1.07888739
35BRSK21.03692026
36PLK41.01291173
37EPHA41.00701890
38PRKCG0.96562108
39SIK20.96444460
40CDC70.95447809
41MINK10.95426508
42UHMK10.93653121
43CDK190.92270619
44PRKCE0.88534016
45EPHA30.86079174
46EPHB20.84970674
47VRK10.82413448
48AKT30.82062528
49CDK30.81851604
50INSRR0.78719484
51YES10.78213425
52PINK10.77538653
53NUAK10.75463983
54ERBB40.75236691
55NEK10.74094138
56LATS10.73268708
57TTK0.72134016
58DYRK1A0.70359511
59NTRK30.69493359
60DYRK1B0.68977331
61PLK10.67108263
62WEE10.64614305
63BUB10.60058634
64CDK50.59999987
65KSR10.58251039
66FGFR20.57519675
67PKN10.57262127
68CHEK20.55042111
69PAK60.54441476
70PAK30.54320833
71PBK0.52657687
72ADRBK20.52134979
73SGK4940.51184489
74SGK2230.51184489
75ATR0.50382787
76CDK180.49933739
77CDK140.49033114
78NEK20.48771676
79SGK20.48276792
80ATM0.48041561
81MAP3K50.46556469
82PRKCZ0.45313759
83CAMK2A0.43518904
84CSNK1D0.43232936
85NME10.42629158
86RPS6KA50.42367514
87CDK150.42267603
88CSNK1E0.41741153
89GRK10.41485708
90CDK11A0.39581192
91CDK10.38978599
92PRKDC0.37817333
93CAMK2B0.37592272
94FLT30.37386363
95CSNK1A10.36311730
96SIK30.36149697
97TGFBR10.35505946
98DAPK20.34977425
99PRKACB0.33372770
100PASK0.31939442

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97401414
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.08518132
3Steroid biosynthesis_Homo sapiens_hsa001002.50096023
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36830575
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33740573
6Fanconi anemia pathway_Homo sapiens_hsa034602.25107279
7GABAergic synapse_Homo sapiens_hsa047272.18657518
8Basal transcription factors_Homo sapiens_hsa030222.13362952
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99266571
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92753450
11Non-homologous end-joining_Homo sapiens_hsa034501.92291443
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90492275
13Butanoate metabolism_Homo sapiens_hsa006501.83050075
14Axon guidance_Homo sapiens_hsa043601.74546058
15Spliceosome_Homo sapiens_hsa030401.71574030
16Protein export_Homo sapiens_hsa030601.71372501
17Mismatch repair_Homo sapiens_hsa034301.70804046
18Morphine addiction_Homo sapiens_hsa050321.68493255
19Phototransduction_Homo sapiens_hsa047441.59459146
20Glutamatergic synapse_Homo sapiens_hsa047241.57684552
21Base excision repair_Homo sapiens_hsa034101.54898022
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49904215
23Selenocompound metabolism_Homo sapiens_hsa004501.48414829
24Taste transduction_Homo sapiens_hsa047421.45725336
25RNA degradation_Homo sapiens_hsa030181.43094220
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42680833
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41470149
28RNA transport_Homo sapiens_hsa030131.39682944
29mRNA surveillance pathway_Homo sapiens_hsa030151.36340873
30Cocaine addiction_Homo sapiens_hsa050301.35171823
31Dopaminergic synapse_Homo sapiens_hsa047281.34587572
32RNA polymerase_Homo sapiens_hsa030201.28873366
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20964398
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19618342
35Hedgehog signaling pathway_Homo sapiens_hsa043401.15638308
36Propanoate metabolism_Homo sapiens_hsa006401.12852054
37Circadian entrainment_Homo sapiens_hsa047131.09382547
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08654409
39Basal cell carcinoma_Homo sapiens_hsa052171.06087082
40Hippo signaling pathway_Homo sapiens_hsa043901.04800104
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04229029
42Cell cycle_Homo sapiens_hsa041101.02661133
43Homologous recombination_Homo sapiens_hsa034401.02560581
44Amphetamine addiction_Homo sapiens_hsa050310.97102612
45Oocyte meiosis_Homo sapiens_hsa041140.97030222
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95934991
47Ether lipid metabolism_Homo sapiens_hsa005650.94799416
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93175991
49Nucleotide excision repair_Homo sapiens_hsa034200.91115410
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90781806
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90654695
52Synaptic vesicle cycle_Homo sapiens_hsa047210.90238575
53Parkinsons disease_Homo sapiens_hsa050120.89139083
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88081200
55Long-term depression_Homo sapiens_hsa047300.87466920
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85218868
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83453636
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81312489
59Oxidative phosphorylation_Homo sapiens_hsa001900.80697614
60Serotonergic synapse_Homo sapiens_hsa047260.80231006
61Gap junction_Homo sapiens_hsa045400.73758506
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72947709
63Linoleic acid metabolism_Homo sapiens_hsa005910.72339132
64Alcoholism_Homo sapiens_hsa050340.71230129
65Olfactory transduction_Homo sapiens_hsa047400.70337306
66DNA replication_Homo sapiens_hsa030300.67663809
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67389389
68Peroxisome_Homo sapiens_hsa041460.66722065
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.63004554
70Huntingtons disease_Homo sapiens_hsa050160.62594678
71beta-Alanine metabolism_Homo sapiens_hsa004100.62434718
72Wnt signaling pathway_Homo sapiens_hsa043100.61290989
73Purine metabolism_Homo sapiens_hsa002300.61129981
74Regulation of autophagy_Homo sapiens_hsa041400.61124546
75Circadian rhythm_Homo sapiens_hsa047100.59748673
76Cholinergic synapse_Homo sapiens_hsa047250.59566344
77Cardiac muscle contraction_Homo sapiens_hsa042600.58905329
78Lysine degradation_Homo sapiens_hsa003100.58548476
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58318387
80TGF-beta signaling pathway_Homo sapiens_hsa043500.57839519
81Colorectal cancer_Homo sapiens_hsa052100.55872998
82Fatty acid elongation_Homo sapiens_hsa000620.54257632
83Insulin secretion_Homo sapiens_hsa049110.51080477
84Type II diabetes mellitus_Homo sapiens_hsa049300.48933261
85Pyrimidine metabolism_Homo sapiens_hsa002400.48667644
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48235090
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46193267
88cAMP signaling pathway_Homo sapiens_hsa040240.44144494
89Tryptophan metabolism_Homo sapiens_hsa003800.44007976
90Fatty acid metabolism_Homo sapiens_hsa012120.40968419
91Metabolic pathways_Homo sapiens_hsa011000.37638665
92Tight junction_Homo sapiens_hsa045300.34691998
93Alzheimers disease_Homo sapiens_hsa050100.32874340
94Caffeine metabolism_Homo sapiens_hsa002320.31940082
95Melanoma_Homo sapiens_hsa052180.30717518
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28552190
97Biosynthesis of amino acids_Homo sapiens_hsa012300.26611895
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25816795
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25712538
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25168649

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