ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	8.14069186
2	positive regulation of action potential (GO:0045760)	7.75436931
3	positive regulation of vascular permeability (GO:0043117)	7.18377038
4	aggressive behavior (GO:0002118)	6.37273207
5	positive regulation of uterine smooth muscle contraction (GO:0070474)	6.18949810
6	positive regulation of digestive system process (GO:0060456)	5.34275433
7	regulation of uterine smooth muscle contraction (GO:0070472)	5.31957204
8	drinking behavior (GO:0042756)	5.29178044
9	positive regulation of male gonad development (GO:2000020)	5.26350522
10	urinary tract smooth muscle contraction (GO:0014848)	5.14673369
11	retinal cone cell development (GO:0046549)	5.11870570
12	positive regulation of synaptic transmission, GABAergic (GO:0032230)	5.01966860
13	regulation of action potential (GO:0098900)	4.72793269
14	heparin metabolic process (GO:0030202)	4.72084759
15	heparin biosynthetic process (GO:0030210)	4.72084759
16	diterpenoid biosynthetic process (GO:0016102)	4.63771530
17	regulation of timing of cell differentiation (GO:0048505)	4.55570852
18	hindbrain development (GO:0030902)	4.24453052
19	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.12272346
20	regulation of male gonad development (GO:2000018)	4.07176092
21	regulation of development, heterochronic (GO:0040034)	3.97584537
22	glomerulus development (GO:0032835)	3.95885861
23	central nervous system projection neuron axonogenesis (GO:0021952)	3.94995180
24	cerebral cortex radially oriented cell migration (GO:0021799)	3.83912392
25	response to auditory stimulus (GO:0010996)	3.80254087
26	replication fork processing (GO:0031297)	3.73275456
27	presynaptic membrane assembly (GO:0097105)	3.68704793
28	retinal rod cell development (GO:0046548)	3.59904380
29	righting reflex (GO:0060013)	3.49763358
30	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.41813614
31	positive regulation of renal sodium excretion (GO:0035815)	3.41359851
32	central nervous system neuron axonogenesis (GO:0021955)	3.40666529
33	negative regulation of astrocyte differentiation (GO:0048712)	3.36572372
34	negative regulation of dendrite development (GO:2000171)	3.34799306
35	inner ear receptor stereocilium organization (GO:0060122)	3.33595103
36	presynaptic membrane organization (GO:0097090)	3.31592935
37	regulation of synaptic transmission, GABAergic (GO:0032228)	3.31182016
38	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.28654804
39	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.28515383
40	regulation of translation, ncRNA-mediated (GO:0045974)	3.28515383
41	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.28515383
42	limb bud formation (GO:0060174)	3.27620825
43	lung secretory cell differentiation (GO:0061140)	3.23208308
44	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.22833882
45	artery development (GO:0060840)	3.17681609
46	terpenoid biosynthetic process (GO:0016114)	3.15137150
47	otic vesicle formation (GO:0030916)	3.07208804
48	neuronal action potential propagation (GO:0019227)	2.99086837
49	behavioral response to pain (GO:0048266)	2.96674473
50	photoreceptor cell development (GO:0042461)	2.91818018
51	cardiac ventricle formation (GO:0003211)	2.90532765
52	eye photoreceptor cell development (GO:0042462)	2.89960024
53	cell differentiation involved in kidney development (GO:0061005)	2.84005769
54	lateral sprouting from an epithelium (GO:0060601)	2.83214751
55	negative regulation of axon guidance (GO:1902668)	2.81344960
56	axonal fasciculation (GO:0007413)	2.81050940
57	photoreceptor cell maintenance (GO:0045494)	2.80158487
58	metanephric mesenchyme development (GO:0072075)	2.75291288
59	tongue development (GO:0043586)	2.75220115
60	neuron recognition (GO:0008038)	2.74976560
61	retinal ganglion cell axon guidance (GO:0031290)	2.74039708
62	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.73040919
63	glutamate receptor signaling pathway (GO:0007215)	2.69092054
64	behavioral response to ethanol (GO:0048149)	2.68940327
65	pancreas development (GO:0031016)	2.67992521
66	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.67872553
67	cardiac chamber formation (GO:0003207)	2.63270512
68	positive regulation of heart growth (GO:0060421)	2.62398607
69	radial glial cell differentiation (GO:0060019)	2.60327005
70	olfactory bulb development (GO:0021772)	2.57563075
71	generation of neurons (GO:0048699)	2.54843938
72	adaptation of signaling pathway (GO:0023058)	2.54488539
73	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	2.54219350
74	negative regulation of axon extension (GO:0030517)	2.53746484
75	pyrimidine nucleobase catabolic process (GO:0006208)	2.53645266
76	kidney mesenchyme development (GO:0072074)	2.52597905
77	nonmotile primary cilium assembly (GO:0035058)	2.52120483
78	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.50637124
79	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.47687929
80	neuronal stem cell maintenance (GO:0097150)	2.45293501
81	regulation of renal sodium excretion (GO:0035813)	2.44550518
82	regulation of energy homeostasis (GO:2000505)	2.44011288
83	reflex (GO:0060004)	2.43033370
84	positive regulation of catenin import into nucleus (GO:0035413)	2.41159028
85	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.40855423
86	axon ensheathment in central nervous system (GO:0032291)	2.39863486
87	central nervous system myelination (GO:0022010)	2.39863486
88	positive regulation of chondrocyte differentiation (GO:0032332)	2.39557457
89	regulation of excretion (GO:0044062)	2.39361051
90	dermatan sulfate biosynthetic process (GO:0030208)	2.38941746
91	neural tube formation (GO:0001841)	2.38873515
92	DNA double-strand break processing (GO:0000729)	2.38818778
93	cerebral cortex cell migration (GO:0021795)	2.37434420
94	regulation of vascular permeability (GO:0043114)	2.35831350
95	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.33611170
96	pituitary gland development (GO:0021983)	2.32099447
97	forebrain neuron differentiation (GO:0021879)	2.31133539
98	smoothened signaling pathway (GO:0007224)	2.30724087
99	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.30702586
100	negative regulation of chondrocyte differentiation (GO:0032331)	2.30297096

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.48368586
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.45741479
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.18842525
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.03385978
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.93993395
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.83069138
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.79382192
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.55600506
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.43065491
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.36630054
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35807581
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31251201
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.26909144
14	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.25895279
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.23561587
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.19430856
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.15669879
18	VDR_22108803_ChIP-Seq_LS180_Human	2.14060632
19	P300_19829295_ChIP-Seq_ESCs_Human	2.07846426
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01890818
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92231513
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90439760
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83706467
24	FUS_26573619_Chip-Seq_HEK293_Human	1.78877104
25	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.72787742
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72426557
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.72080122
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.71144362
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.70330257
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.67068116
31	EWS_26573619_Chip-Seq_HEK293_Human	1.61530532
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59684747
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57779866
34	AR_25329375_ChIP-Seq_VCAP_Human	1.56190367
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.54935758
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.54832541
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54832541
38	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.53211502
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.52117217
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51615382
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51476826
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.50823292
43	STAT3_23295773_ChIP-Seq_U87_Human	1.50046693
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49684077
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.48800319
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.47469162
47	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47393722
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47097916
49	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46590929
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45977575
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45850095
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.45376651
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43399522
54	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.42832273
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40638273
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40301709
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40301709
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39388087
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.39255079
60	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.37851782
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.37438760
62	TCF4_23295773_ChIP-Seq_U87_Human	1.33738879
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32645618
64	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.31011267
65	AHR_22903824_ChIP-Seq_MCF-7_Human	1.28302736
66	P53_22387025_ChIP-Seq_ESCs_Mouse	1.27265327
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26301667
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.24429587
69	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.24374533
70	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.23586282
71	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.23119658
72	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.22236405
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.22072012
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.21813829
75	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.20732863
76	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.20607315
77	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19717916
78	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.19534703
79	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18599177
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18539829
81	TP53_16413492_ChIP-PET_HCT116_Human	1.18317901
82	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18207749
83	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.16982858
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15104764
85	KDM2B_26808549_Chip-Seq_REH_Human	1.14512844
86	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13952964
87	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12355613
88	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11100015
89	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.10767966
90	SOX9_26525672_Chip-Seq_HEART_Mouse	1.09791122
91	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.09565354
92	CJUN_26792858_Chip-Seq_BT549_Human	1.09525807
93	RXR_22108803_ChIP-Seq_LS180_Human	1.08801969
94	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08673961
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08655240
96	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.08505634
97	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07569960
98	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07569960
99	DROSHA_22980978_ChIP-Seq_HELA_Human	1.07555663
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07298921

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	4.98725048
2	MP0001529_abnormal_vocalization	3.92337288
3	MP0001968_abnormal_touch/_nociception	3.80711922
4	MP0003283_abnormal_digestive_organ	3.79849611
5	MP0002735_abnormal_chemical_nociception	3.17785154
6	MP0002277_abnormal_respiratory_mucosa	2.93696179
7	MP0005503_abnormal_tendon_morphology	2.86345367
8	MP0002938_white_spotting	2.49331229
9	MP0004885_abnormal_endolymph	2.20615781
10	MP0005248_abnormal_Harderian_gland	2.13409681
11	MP0000778_abnormal_nervous_system	2.12231528
12	MP0000566_synostosis	1.97665818
13	MP0009250_abnormal_appendicular_skeleto	1.96425277
14	MP0002734_abnormal_mechanical_nocicepti	1.94136407
15	MP0000049_abnormal_middle_ear	1.91668460
16	MP0005275_abnormal_skin_tensile	1.83387486
17	MP0009780_abnormal_chondrocyte_physiolo	1.82170595
18	MP0002234_abnormal_pharynx_morphology	1.81168321
19	MP0005253_abnormal_eye_physiology	1.77789654
20	MP0009384_cardiac_valve_regurgitation	1.63054241
21	MP0004270_analgesia	1.61872324
22	MP0005551_abnormal_eye_electrophysiolog	1.57977703
23	MP0003136_yellow_coat_color	1.53578734
24	MP0003937_abnormal_limbs/digits/tail_de	1.53408199
25	MP0005367_renal/urinary_system_phenotyp	1.50872011
26	MP0000516_abnormal_urinary_system	1.50872011
27	MP0008877_abnormal_DNA_methylation	1.46805294
28	MP0002282_abnormal_trachea_morphology	1.46431828
29	MP0009697_abnormal_copulation	1.45335405
30	MP0006072_abnormal_retinal_apoptosis	1.43899332
31	MP0001346_abnormal_lacrimal_gland	1.41729098
32	MP0000631_abnormal_neuroendocrine_gland	1.39523489
33	MP0004924_abnormal_behavior	1.38838367
34	MP0005386_behavior/neurological_phenoty	1.38838367
35	MP0002233_abnormal_nose_morphology	1.35597067
36	MP0006292_abnormal_olfactory_placode	1.34318238
37	MP0001984_abnormal_olfaction	1.33419779
38	MP0003119_abnormal_digestive_system	1.32667520
39	MP0002751_abnormal_autonomic_nervous	1.31208199
40	MP0002272_abnormal_nervous_system	1.30238621
41	MP0000749_muscle_degeneration	1.29612420
42	MP0009745_abnormal_behavioral_response	1.28952931
43	MP0002067_abnormal_sensory_capabilities	1.28210130
44	MP0010030_abnormal_orbit_morphology	1.24324915
45	MP0003755_abnormal_palate_morphology	1.22165535
46	MP0001486_abnormal_startle_reflex	1.17612924
47	MP0002572_abnormal_emotion/affect_behav	1.17107059
48	MP0003935_abnormal_craniofacial_develop	1.14762219
49	MP0009053_abnormal_anal_canal	1.10191838
50	MP0002102_abnormal_ear_morphology	1.10175868
51	MP0008789_abnormal_olfactory_epithelium	1.09423234
52	MP0000569_abnormal_digit_pigmentation	1.08969811
53	MP0005195_abnormal_posterior_eye	1.08201031
54	MP0002697_abnormal_eye_size	1.06324370
55	MP0002108_abnormal_muscle_morphology	1.05873534
56	MP0006054_spinal_hemorrhage	1.01536419
57	MP0003115_abnormal_respiratory_system	1.01323755
58	MP0000026_abnormal_inner_ear	1.00376430
59	MP0003698_abnormal_male_reproductive	1.00277894
60	MP0003880_abnormal_central_pattern	0.99729762
61	MP0003635_abnormal_synaptic_transmissio	0.96271283
62	MP0004742_abnormal_vestibular_system	0.96104890
63	MP0004859_abnormal_synaptic_plasticity	0.95786644
64	MP0001177_atelectasis	0.94459865
65	MP0002168_other_aberrant_phenotype	0.93834151
66	MP0001286_abnormal_eye_development	0.92829777
67	MP0001299_abnormal_eye_distance/	0.92373413
68	MP0010368_abnormal_lymphatic_system	0.92179113
69	MP0005391_vision/eye_phenotype	0.91987679
70	MP0005187_abnormal_penis_morphology	0.91696346
71	MP0000462_abnormal_digestive_system	0.91687094
72	MP0005508_abnormal_skeleton_morphology	0.90051077
73	MP0001970_abnormal_pain_threshold	0.89968036
74	MP0000432_abnormal_head_morphology	0.89774374
75	MP0000383_abnormal_hair_follicle	0.88985969
76	MP0002557_abnormal_social/conspecific_i	0.88659528
77	MP0008872_abnormal_physiological_respon	0.86897431
78	MP0003938_abnormal_ear_development	0.86083337
79	MP0000428_abnormal_craniofacial_morphol	0.85845851
80	MP0002116_abnormal_craniofacial_bone	0.85113888
81	MP0001485_abnormal_pinna_reflex	0.82671007
82	MP0002896_abnormal_bone_mineralization	0.82622865
83	MP0002249_abnormal_larynx_morphology	0.81833543
84	MP0000534_abnormal_ureter_morphology	0.81728873
85	MP0002752_abnormal_somatic_nervous	0.79338679
86	MP0005394_taste/olfaction_phenotype	0.79302979
87	MP0005499_abnormal_olfactory_system	0.79302979
88	MP0001929_abnormal_gametogenesis	0.79206520
89	MP0003385_abnormal_body_wall	0.78948888
90	MP0002210_abnormal_sex_determination	0.77741194
91	MP0003646_muscle_fatigue	0.77358833
92	MP0003861_abnormal_nervous_system	0.76568973
93	MP0002882_abnormal_neuron_morphology	0.76091060
94	MP0003942_abnormal_urinary_system	0.75373281
95	MP0002063_abnormal_learning/memory/cond	0.74735109
96	MP0001919_abnormal_reproductive_system	0.72223543
97	MP0002109_abnormal_limb_morphology	0.70652066
98	MP0000955_abnormal_spinal_cord	0.70209115
99	MP0000163_abnormal_cartilage_morphology	0.69668389
100	MP0005395_other_phenotype	0.69336969

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neonatal short-limb short stature (HP:0008921)	4.10946724
2	Vitreoretinal degeneration (HP:0000655)	3.91970241
3	Absent frontal sinuses (HP:0002688)	3.91068684
4	True hermaphroditism (HP:0010459)	3.66640659
5	Hypoplastic ischia (HP:0003175)	3.65206274
6	Mesangial abnormality (HP:0001966)	3.41470331
7	Hyperventilation (HP:0002883)	3.41422419
8	Abnormality of the ischium (HP:0003174)	3.34779330
9	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	3.31039143
10	Long clavicles (HP:0000890)	3.26937637
11	Bony spicule pigmentary retinopathy (HP:0007737)	3.21926252
12	Short 4th metacarpal (HP:0010044)	3.18700971
13	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.18700971
14	Anomalous pulmonary venous return (HP:0010772)	3.16160085
15	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.15995227
16	Metaphyseal dysplasia (HP:0100255)	3.12401087
17	Renal cortical cysts (HP:0000803)	3.06565383
18	Hypoplastic nipples (HP:0002557)	3.02665876
19	Renal hypoplasia (HP:0000089)	2.96321885
20	Abnormality of the renal cortex (HP:0011035)	2.84008419
21	Abnormality of the pulmonary veins (HP:0011718)	2.83355328
22	Gait imbalance (HP:0002141)	2.82765923
23	Abnormality of midbrain morphology (HP:0002418)	2.75170515
24	Molar tooth sign on MRI (HP:0002419)	2.75170515
25	Fibular hypoplasia (HP:0003038)	2.74610942
26	Medial flaring of the eyebrow (HP:0010747)	2.71743277
27	Abnormality of the frontal sinuses (HP:0002687)	2.70629502
28	Attenuation of retinal blood vessels (HP:0007843)	2.61313511
29	Bifid scrotum (HP:0000048)	2.56451897
30	Focal motor seizures (HP:0011153)	2.52609198
31	Natal tooth (HP:0000695)	2.50575499
32	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.50376403
33	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.47509230
34	Volvulus (HP:0002580)	2.44981672
35	Tibial bowing (HP:0002982)	2.34938358
36	Abnormality of the 4th metacarpal (HP:0010012)	2.33951007
37	Hypoplastic left heart (HP:0004383)	2.32022883
38	Focal seizures (HP:0007359)	2.31670117
39	Abnormal lung lobation (HP:0002101)	2.31609116
40	Atonic seizures (HP:0010819)	2.31263920
41	Tubular atrophy (HP:0000092)	2.31186963
42	Neoplasm of the oral cavity (HP:0100649)	2.28344005
43	Action tremor (HP:0002345)	2.26483042
44	Preaxial foot polydactyly (HP:0001841)	2.25408604
45	Congenital primary aphakia (HP:0007707)	2.24549785
46	Abolished electroretinogram (ERG) (HP:0000550)	2.24339235
47	Tubulointerstitial fibrosis (HP:0005576)	2.22715757
48	Nephronophthisis (HP:0000090)	2.21559627
49	Thyroid-stimulating hormone excess (HP:0002925)	2.19460535
50	Ectopic kidney (HP:0000086)	2.18161236
51	Enlarged epiphyses (HP:0010580)	2.16579111
52	Tubulointerstitial abnormality (HP:0001969)	2.16055726
53	Chromsome breakage (HP:0040012)	2.15906288
54	Median cleft lip (HP:0000161)	2.15274229
55	Postaxial hand polydactyly (HP:0001162)	2.14656718
56	Astigmatism (HP:0000483)	2.12256394
57	Postaxial foot polydactyly (HP:0001830)	2.12144468
58	Amyotrophic lateral sclerosis (HP:0007354)	2.11852886
59	Asymmetry of the thorax (HP:0001555)	2.11768043
60	Intestinal atresia (HP:0011100)	2.09702810
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09005789
62	Oligodactyly (HP:0012165)	2.06724938
63	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.05299817
64	Small hand (HP:0200055)	2.03284250
65	Complete atrioventricular canal defect (HP:0001674)	2.00075109
66	Genital tract atresia (HP:0001827)	2.00003396
67	Nephrogenic diabetes insipidus (HP:0009806)	1.98667828
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.98580988
69	Irregular vertebral endplates (HP:0003301)	1.97697737
70	Abnormality of the renal medulla (HP:0100957)	1.96488697
71	Pancreatic fibrosis (HP:0100732)	1.95376442
72	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93015759
73	Short ribs (HP:0000773)	1.92742300
74	Palpebral edema (HP:0100540)	1.91347635
75	Oligodactyly (hands) (HP:0001180)	1.88965186
76	Increased corneal curvature (HP:0100692)	1.88785424
77	Keratoconus (HP:0000563)	1.88785424
78	Febrile seizures (HP:0002373)	1.88287330
79	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86340156
80	Zonular cataract (HP:0010920)	1.84073491
81	Cutaneous finger syndactyly (HP:0010554)	1.83929098
82	Arthropathy (HP:0003040)	1.83472300
83	Decreased central vision (HP:0007663)	1.81794176
84	Hypoproteinemia (HP:0003075)	1.80276862
85	Facial hemangioma (HP:0000329)	1.80047825
86	Hypoplastic iliac wings (HP:0002866)	1.79681602
87	Embryonal renal neoplasm (HP:0011794)	1.79536716
88	Abnormality of the antihelix (HP:0009738)	1.79100267
89	Hypoplastic heart (HP:0001961)	1.78919814
90	Pancreatic cysts (HP:0001737)	1.76665704
91	Microglossia (HP:0000171)	1.76603831
92	Midline defect of the nose (HP:0004122)	1.76516395
93	Hypoplasia of the thymus (HP:0000778)	1.75782515
94	Vaginal atresia (HP:0000148)	1.75387355
95	Nephroblastoma (Wilms tumor) (HP:0002667)	1.74527707
96	Male pseudohermaphroditism (HP:0000037)	1.74353739
97	Focal segmental glomerulosclerosis (HP:0000097)	1.73980575
98	Metaphyseal cupping (HP:0003021)	1.72848562
99	Abnormality of chromosome stability (HP:0003220)	1.72586913
100	Tracheomalacia (HP:0002779)	1.72516678

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	4.83621455
2	PNCK	3.80963549
3	MAPK13	3.79550843
4	FRK	3.03625260
5	INSRR	2.85872457
6	CAMKK2	2.85059030
7	MARK1	2.73214421
8	BRSK2	2.67669630
9	WNK3	2.46126849
10	WEE1	2.38713563
11	NLK	2.26903132
12	NTRK3	2.22395428
13	BMPR1B	2.04840934
14	NUAK1	1.95574022
15	LATS1	1.75204132
16	CASK	1.69263591
17	SGK2	1.59947261
18	CAMK1G	1.49697622
19	EPHA3	1.39910694
20	IRAK1	1.38471078
21	MAP3K4	1.36099044
22	PKN1	1.29675302
23	CAMK1D	1.29482623
24	PRKCE	1.27749825
25	FGFR2	1.26304023
26	PHKG1	1.24797938
27	PHKG2	1.24797938
28	GRK1	1.24182645
29	STK3	1.22901328
30	EPHB2	1.21926174
31	PIK3CG	1.20155304
32	BCR	1.18745544
33	EPHA4	1.17318604
34	PLK4	1.10945464
35	DYRK3	1.10123425
36	DYRK2	1.09514543
37	MAPK15	1.06772474
38	VRK1	1.00627694
39	MKNK2	1.00361038
40	NTRK2	0.99426477
41	AKT3	0.98675285
42	MAP3K10	0.98289055
43	ZAK	0.97329504
44	SGK223	0.93462870
45	SGK494	0.93462870
46	ADRBK2	0.93009033
47	TIE1	0.90280412
48	PRKCG	0.88032244
49	BRSK1	0.86531209
50	STK11	0.81125142
51	DAPK2	0.77311774
52	CDK3	0.74599034
53	STK39	0.72158679
54	CAMK4	0.72124966
55	TYRO3	0.72087594
56	ROCK1	0.71041141
57	PTK2B	0.70537513
58	NEK9	0.69837476
59	EIF2AK2	0.66206057
60	MAP3K12	0.66198677
61	PAK3	0.65921835
62	SGK3	0.64560495
63	MAP2K7	0.61898109
64	DMPK	0.61861297
65	CAMK2B	0.60972171
66	KSR1	0.59521652
67	DYRK1A	0.58958725
68	TGFBR1	0.56658503
69	TTK	0.56445910
70	TSSK6	0.56282592
71	CAMKK1	0.56260339
72	GSK3A	0.55030327
73	SGK1	0.54663589
74	CSNK1D	0.53612512
75	CCNB1	0.52688827
76	PINK1	0.52398640
77	STK38L	0.51031780
78	MAPKAPK5	0.51005551
79	MAP2K4	0.49680175
80	MKNK1	0.48734064
81	MYLK	0.47239163
82	PLK2	0.46835604
83	PRKCZ	0.44777571
84	PRKAA1	0.43903348
85	CAMK2A	0.43552663
86	MAP4K2	0.42670741
87	YES1	0.41941120
88	RPS6KB1	0.41566798
89	MAP3K6	0.41177578
90	PRKAA2	0.39514462
91	PLK3	0.38577530
92	JAK3	0.38046002
93	CAMK1	0.36908307
94	ACVR1B	0.36357773
95	ATM	0.33381971
96	RAF1	0.33276105
97	ERBB2	0.32959040
98	ADRBK1	0.31967551
99	PRKACA	0.29870189
100	PRKG1	0.29445501

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.80150989
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.73324560
3	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.49577241
4	Taste transduction_Homo sapiens_hsa04742	2.45810492
5	ABC transporters_Homo sapiens_hsa02010	2.37694371
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37577698
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.34883524
8	Nicotine addiction_Homo sapiens_hsa05033	2.33309844
9	Homologous recombination_Homo sapiens_hsa03440	2.26021648
10	Basal cell carcinoma_Homo sapiens_hsa05217	2.04930068
11	Phototransduction_Homo sapiens_hsa04744	1.99323620
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85874377
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85509268
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.79548614
15	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.74044993
16	Circadian rhythm_Homo sapiens_hsa04710	1.72060872
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.67738226
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.59798936
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.51987768
20	Axon guidance_Homo sapiens_hsa04360	1.50387983
21	Olfactory transduction_Homo sapiens_hsa04740	1.48512548
22	Butanoate metabolism_Homo sapiens_hsa00650	1.44241226
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.38580593
24	Circadian entrainment_Homo sapiens_hsa04713	1.34214457
25	Calcium signaling pathway_Homo sapiens_hsa04020	1.27047043
26	Cocaine addiction_Homo sapiens_hsa05030	1.24283934
27	Morphine addiction_Homo sapiens_hsa05032	1.21906678
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19459479
29	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.15950547
30	Regulation of autophagy_Homo sapiens_hsa04140	1.15674259
31	Amphetamine addiction_Homo sapiens_hsa05031	1.13511068
32	cAMP signaling pathway_Homo sapiens_hsa04024	1.10095561
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08392498
34	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.04644170
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.02255172
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99883670
37	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.99002099
38	Gap junction_Homo sapiens_hsa04540	0.98837689
39	Long-term depression_Homo sapiens_hsa04730	0.97044170
40	Renin secretion_Homo sapiens_hsa04924	0.94023904
41	Type II diabetes mellitus_Homo sapiens_hsa04930	0.93881443
42	Hippo signaling pathway_Homo sapiens_hsa04390	0.93535007
43	Melanoma_Homo sapiens_hsa05218	0.93397786
44	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.92825133
45	African trypanosomiasis_Homo sapiens_hsa05143	0.92721077
46	Dopaminergic synapse_Homo sapiens_hsa04728	0.89278112
47	GABAergic synapse_Homo sapiens_hsa04727	0.88653507
48	Basal transcription factors_Homo sapiens_hsa03022	0.86616991
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85862204
50	Protein digestion and absorption_Homo sapiens_hsa04974	0.84472566
51	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.84210398
52	Estrogen signaling pathway_Homo sapiens_hsa04915	0.82540777
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.79546536
54	Propanoate metabolism_Homo sapiens_hsa00640	0.79185032
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79180348
56	Cholinergic synapse_Homo sapiens_hsa04725	0.78206664
57	Insulin secretion_Homo sapiens_hsa04911	0.78205703
58	Salivary secretion_Homo sapiens_hsa04970	0.77756120
59	Tight junction_Homo sapiens_hsa04530	0.77665936
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76868474
61	Ras signaling pathway_Homo sapiens_hsa04014	0.75406350
62	Protein export_Homo sapiens_hsa03060	0.74940608
63	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.74782882
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.74286555
65	Melanogenesis_Homo sapiens_hsa04916	0.74224505
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74182435
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.72649678
68	Serotonergic synapse_Homo sapiens_hsa04726	0.72336579
69	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.70838338
70	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.69413820
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68869028
72	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.67125922
73	ECM-receptor interaction_Homo sapiens_hsa04512	0.66517212
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66052092
75	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.63554090
76	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.63512268
77	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.62975892
78	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.62219536
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61708798
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61279325
81	Choline metabolism in cancer_Homo sapiens_hsa05231	0.61088850
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.60460163
83	Prostate cancer_Homo sapiens_hsa05215	0.59684074
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57607845
85	Histidine metabolism_Homo sapiens_hsa00340	0.56311859
86	Folate biosynthesis_Homo sapiens_hsa00790	0.54174964
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.53752933
88	mTOR signaling pathway_Homo sapiens_hsa04150	0.52440861
89	Gastric acid secretion_Homo sapiens_hsa04971	0.51180011
90	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.51070580
91	ErbB signaling pathway_Homo sapiens_hsa04012	0.50566515
92	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.50208115
93	Retinol metabolism_Homo sapiens_hsa00830	0.50005049
94	MicroRNAs in cancer_Homo sapiens_hsa05206	0.48208622
95	Rap1 signaling pathway_Homo sapiens_hsa04015	0.48124104
96	Lysine degradation_Homo sapiens_hsa00310	0.47460287
97	Pancreatic secretion_Homo sapiens_hsa04972	0.46532390
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46071384
99	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.44803668
100	Long-term potentiation_Homo sapiens_hsa04720	0.44609401

ZNF300P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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