ZNF302

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the zinc-finger protein family. The encoded protein contains seven C2H2-type zinc fingers and a KRAB domain, but its function has yet to be determined. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization during cardiac muscle cell action potential (GO:0086013)7.36949958
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)7.20534144
3membrane repolarization during action potential (GO:0086011)6.54762316
4cellular potassium ion homeostasis (GO:0030007)5.86707817
5behavioral response to nicotine (GO:0035095)5.49086972
6parturition (GO:0007567)5.22686733
7magnesium ion transport (GO:0015693)5.21263280
8membrane repolarization (GO:0086009)5.06717673
9regulation of membrane repolarization (GO:0060306)4.80122174
10regulation of skeletal muscle contraction (GO:0014819)4.75543645
11positive regulation of potassium ion transmembrane transport (GO:1901381)4.65736099
12cell proliferation in forebrain (GO:0021846)4.41755054
13substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.29516638
14substrate-independent telencephalic tangential migration (GO:0021826)4.29516638
15regulation of potassium ion transmembrane transport (GO:1901379)3.99921996
16positive regulation of synapse maturation (GO:0090129)3.91678519
17potassium ion import (GO:0010107)3.86348166
18retinal ganglion cell axon guidance (GO:0031290)3.81476228
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.77726229
20NADH dehydrogenase complex assembly (GO:0010257)3.77726229
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.77726229
22striatum development (GO:0021756)3.77409938
23negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.68868300
24cardiovascular system development (GO:0072358)3.63749118
25negative regulation of axon extension involved in axon guidance (GO:0048843)3.62663014
26vitamin catabolic process (GO:0009111)3.57686597
27fat-soluble vitamin catabolic process (GO:0042363)3.57686597
28regulation of DNA endoreduplication (GO:0032875)3.57455520
29cellular response to electrical stimulus (GO:0071257)3.54461721
30pyrimidine nucleobase catabolic process (GO:0006208)3.53742945
31protein polyglutamylation (GO:0018095)3.47487676
32cellular anion homeostasis (GO:0030002)3.45710348
33potassium ion homeostasis (GO:0055075)3.44063476
34protein complex biogenesis (GO:0070271)3.40872530
35protein localization to synapse (GO:0035418)3.39491625
36regulation of synapse maturation (GO:0090128)3.36177343
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33747256
38negative regulation of potassium ion transmembrane transport (GO:1901380)3.33588840
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28832246
40positive regulation of potassium ion transport (GO:0043268)3.23534928
41postsynaptic membrane organization (GO:0001941)3.23314351
42negative regulation of axon guidance (GO:1902668)3.22129962
43ovulation cycle (GO:0042698)3.19877991
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.19251644
45positive regulation of gastrulation (GO:2000543)3.17248136
46membrane depolarization during action potential (GO:0086010)3.16111436
47cellular response to exogenous dsRNA (GO:0071360)3.15847913
48negative regulation of response to food (GO:0032096)3.15189437
49negative regulation of appetite (GO:0032099)3.15189437
50regulation of mesoderm development (GO:2000380)3.11935229
51regulation of heart rate by cardiac conduction (GO:0086091)3.09279472
52transmission of nerve impulse (GO:0019226)3.09123085
53relaxation of cardiac muscle (GO:0055119)3.06131524
54negative regulation of protein localization to cell surface (GO:2000009)3.06023460
55spinal cord development (GO:0021510)3.03142429
56regulation of potassium ion transport (GO:0043266)3.01603019
57dentate gyrus development (GO:0021542)3.00005318
58mitochondrial respiratory chain complex assembly (GO:0033108)2.95674000
59negative regulation of systemic arterial blood pressure (GO:0003085)2.94543166
60cerebellar Purkinje cell differentiation (GO:0021702)2.94420643
61somite development (GO:0061053)2.92890782
62neurofilament cytoskeleton organization (GO:0060052)2.90593415
63sulfation (GO:0051923)2.89853590
64regulation of potassium ion transmembrane transporter activity (GO:1901016)2.89815266
65nonmotile primary cilium assembly (GO:0035058)2.88992289
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86341114
67regulation of cilium movement (GO:0003352)2.85837417
68presynaptic membrane organization (GO:0097090)2.84318115
69multicellular organismal signaling (GO:0035637)2.84259148
70epithelial cilium movement (GO:0003351)2.83559815
71gamma-aminobutyric acid transport (GO:0015812)2.83298411
72response to electrical stimulus (GO:0051602)2.82248368
73synapse assembly (GO:0007416)2.81795439
74ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.80824139
75negative regulation of sodium ion transport (GO:0010766)2.77915641
76vitamin D metabolic process (GO:0042359)2.74957076
77genetic imprinting (GO:0071514)2.74118806
78phosphate ion homeostasis (GO:0055062)2.73709244
79trivalent inorganic anion homeostasis (GO:0072506)2.73709244
80locomotory exploration behavior (GO:0035641)2.73165666
81cornea development in camera-type eye (GO:0061303)2.71947833
82nucleobase catabolic process (GO:0046113)2.71093316
83behavioral defense response (GO:0002209)2.67745840
84behavioral fear response (GO:0001662)2.67745840
85neuron recognition (GO:0008038)2.65708769
86regulation of synapse structural plasticity (GO:0051823)2.65011026
87positive regulation of growth hormone secretion (GO:0060124)2.64276973
88interferon-gamma secretion (GO:0072643)2.60861676
89ganglion development (GO:0061548)2.59923506
90regulation of microtubule-based movement (GO:0060632)2.59507554
91auditory behavior (GO:0031223)2.59347536
92axon ensheathment in central nervous system (GO:0032291)2.59338520
93central nervous system myelination (GO:0022010)2.59338520
94fear response (GO:0042596)2.59032513
95cardiac conduction (GO:0061337)2.56559736
96neuron maturation (GO:0042551)2.56517112
97DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.55467046
98axonal fasciculation (GO:0007413)2.54987354
99axon extension involved in axon guidance (GO:0048846)2.54063381
100neuron projection extension involved in neuron projection guidance (GO:1902284)2.54063381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.31509564
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.95049753
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85258511
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78211921
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71144625
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.68316748
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.59187334
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.46694585
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41259659
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39873782
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35302354
12REST_21632747_ChIP-Seq_MESCs_Mouse2.34828521
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.34100922
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28254520
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26156997
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.19579553
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17103373
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17103373
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10999055
20VDR_22108803_ChIP-Seq_LS180_Human2.10251003
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09644440
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.07939169
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.02889160
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02561216
25RNF2_27304074_Chip-Seq_NSC_Mouse2.02358638
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01520766
27IRF1_19129219_ChIP-ChIP_H3396_Human1.97063507
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94816591
29GBX2_23144817_ChIP-Seq_PC3_Human1.89751396
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.83918356
31ZNF274_21170338_ChIP-Seq_K562_Hela1.81289589
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79894853
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77118462
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75758210
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.66846162
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63464202
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.60982725
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59235484
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57681463
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51459586
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50686218
42TAF15_26573619_Chip-Seq_HEK293_Human1.42325120
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38157760
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36499084
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33539227
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32770516
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27413042
48P300_19829295_ChIP-Seq_ESCs_Human1.25568923
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25406060
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25155762
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25155762
52* EWS_26573619_Chip-Seq_HEK293_Human1.23465532
53IGF1R_20145208_ChIP-Seq_DFB_Human1.21500119
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19088844
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16713551
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.15709273
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15393896
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14377464
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14161411
60AR_25329375_ChIP-Seq_VCAP_Human1.12503893
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.11778682
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11215083
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10941879
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09861215
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09482147
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09312706
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07526334
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07409002
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06779471
70AR_21572438_ChIP-Seq_LNCaP_Human1.05787621
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05343885
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.05226753
73DROSHA_22980978_ChIP-Seq_HELA_Human1.05102478
74SMAD4_21799915_ChIP-Seq_A2780_Human1.04453814
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04198301
76ER_23166858_ChIP-Seq_MCF-7_Human1.03799116
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03537161
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01738806
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01650082
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01358407
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99243066
82RXR_22108803_ChIP-Seq_LS180_Human0.98603992
83JUN_21703547_ChIP-Seq_K562_Human0.96956955
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96270549
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.95793902
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95341294
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.94750358
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94308410
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.93571636
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93346277
91CBP_20019798_ChIP-Seq_JUKART_Human0.93346277
92FUS_26573619_Chip-Seq_HEK293_Human0.92345892
93TCF4_23295773_ChIP-Seq_U87_Human0.91775639
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.90799414
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90633668
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90120156
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89893173
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89196259
99NCOR_22424771_ChIP-Seq_293T_Human0.89033909
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87554986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.88732096
2MP0003123_paternal_imprinting3.46562617
3MP0006292_abnormal_olfactory_placode3.35981819
4MP0001440_abnormal_grooming_behavior2.34234892
5MP0002163_abnormal_gland_morphology2.31949995
6MP0002160_abnormal_reproductive_system2.30287851
7MP0008877_abnormal_DNA_methylation2.28047746
8MP0004885_abnormal_endolymph2.23823743
9MP0003880_abnormal_central_pattern2.21665392
10MP0005646_abnormal_pituitary_gland2.20399825
11MP0003121_genomic_imprinting2.19964388
12MP0004145_abnormal_muscle_electrophysio2.15881841
13MP0005423_abnormal_somatic_nervous2.14462882
14MP0002822_catalepsy2.13127110
15MP0002653_abnormal_ependyma_morphology2.07882723
16MP0000778_abnormal_nervous_system2.03318275
17MP0001485_abnormal_pinna_reflex2.02941208
18MP0001188_hyperpigmentation1.99202922
19MP0008789_abnormal_olfactory_epithelium1.93862467
20MP0004859_abnormal_synaptic_plasticity1.91759043
21MP0002272_abnormal_nervous_system1.91578058
22MP0002638_abnormal_pupillary_reflex1.89274937
23MP0003122_maternal_imprinting1.83104108
24MP0006276_abnormal_autonomic_nervous1.82619277
25MP0000631_abnormal_neuroendocrine_gland1.76311775
26MP0003635_abnormal_synaptic_transmissio1.73018067
27MP0002557_abnormal_social/conspecific_i1.67663628
28MP0009745_abnormal_behavioral_response1.66918598
29MP0002184_abnormal_innervation1.64753927
30MP0004133_heterotaxia1.61618777
31MP0002063_abnormal_learning/memory/cond1.60476709
32MP0005394_taste/olfaction_phenotype1.59834626
33MP0005499_abnormal_olfactory_system1.59834626
34MP0004130_abnormal_muscle_cell1.59429685
35MP0005389_reproductive_system_phenotype1.57362315
36MP0000955_abnormal_spinal_cord1.52767141
37MP0000569_abnormal_digit_pigmentation1.51713107
38MP0003646_muscle_fatigue1.48216469
39MP0003011_delayed_dark_adaptation1.45402502
40MP0005551_abnormal_eye_electrophysiolog1.44825528
41MP0002572_abnormal_emotion/affect_behav1.44166037
42MP0000049_abnormal_middle_ear1.43670576
43MP0005645_abnormal_hypothalamus_physiol1.43338956
44MP0006072_abnormal_retinal_apoptosis1.41699235
45MP0003879_abnormal_hair_cell1.40714265
46MP0004142_abnormal_muscle_tone1.37321613
47MP0001970_abnormal_pain_threshold1.36685514
48MP0002064_seizures1.34942391
49MP0004742_abnormal_vestibular_system1.33807081
50MP0001529_abnormal_vocalization1.31042653
51MP0003942_abnormal_urinary_system1.27833047
52MP0002733_abnormal_thermal_nociception1.27413751
53MP0002752_abnormal_somatic_nervous1.24708020
54MP0001486_abnormal_startle_reflex1.24707766
55MP0003890_abnormal_embryonic-extraembry1.24684591
56MP0002882_abnormal_neuron_morphology1.23196941
57MP0001905_abnormal_dopamine_level1.21203674
58MP0003136_yellow_coat_color1.18762654
59MP0005379_endocrine/exocrine_gland_phen1.18664997
60MP0009379_abnormal_foot_pigmentation1.17562974
61MP0000026_abnormal_inner_ear1.16984891
62MP0001986_abnormal_taste_sensitivity1.15728844
63MP0002837_dystrophic_cardiac_calcinosis1.15640994
64MP0009046_muscle_twitch1.13112262
65MP0002067_abnormal_sensory_capabilities1.13032200
66MP0002938_white_spotting1.10960005
67MP0001968_abnormal_touch/_nociception1.09793810
68MP0004019_abnormal_vitamin_homeostasis1.07847952
69MP0002152_abnormal_brain_morphology1.06449338
70MP0005195_abnormal_posterior_eye1.06307927
71MP0009250_abnormal_appendicular_skeleto1.02329909
72MP0001879_abnormal_lymphatic_vessel1.00529340
73MP0003755_abnormal_palate_morphology1.00084222
74MP0001542_abnormal_bone_strength0.99476289
75MP0002928_abnormal_bile_duct0.98867138
76MP0002734_abnormal_mechanical_nocicepti0.97983386
77MP0002735_abnormal_chemical_nociception0.97491365
78MP0002102_abnormal_ear_morphology0.94852102
79MP0001963_abnormal_hearing_physiology0.93689508
80MP0000230_abnormal_systemic_arterial0.93292699
81MP0001919_abnormal_reproductive_system0.92259800
82MP0001293_anophthalmia0.91442998
83MP0001502_abnormal_circadian_rhythm0.90752958
84MP0003315_abnormal_perineum_morphology0.90652510
85MP0004085_abnormal_heartbeat0.89343932
86MP0003938_abnormal_ear_development0.89110875
87MP0004811_abnormal_neuron_physiology0.88934468
88MP0005386_behavior/neurological_phenoty0.87561090
89MP0004924_abnormal_behavior0.87561090
90MP0003861_abnormal_nervous_system0.87281139
91MP0002116_abnormal_craniofacial_bone0.84352904
92MP0009053_abnormal_anal_canal0.83748735
93MP0003385_abnormal_body_wall0.82632857
94MP0003937_abnormal_limbs/digits/tail_de0.81927106
95MP0001984_abnormal_olfaction0.80072551
96MP0005409_darkened_coat_color0.79543671
97MP0005084_abnormal_gallbladder_morpholo0.79497117
98MP0003119_abnormal_digestive_system0.78954538
99MP0008872_abnormal_physiological_respon0.75628783
100MP0002138_abnormal_hepatobiliary_system0.75375178

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)4.16423150
2Progressive cerebellar ataxia (HP:0002073)3.57127956
3Nephronophthisis (HP:0000090)3.42639585
4Oligodontia (HP:0000677)3.33293259
5Septo-optic dysplasia (HP:0100842)3.23451958
6Molar tooth sign on MRI (HP:0002419)3.17295280
7Abnormality of midbrain morphology (HP:0002418)3.17295280
8Myokymia (HP:0002411)3.09429709
9Persistence of primary teeth (HP:0006335)3.09327896
10Short femoral neck (HP:0100864)3.06913308
11Pancreatic fibrosis (HP:0100732)3.02199374
12Asplenia (HP:0001746)2.96996829
13Pancreatic cysts (HP:0001737)2.92512729
14Abnormality of the renal medulla (HP:0100957)2.91446195
15Adrenal hypoplasia (HP:0000835)2.88133034
16Medial flaring of the eyebrow (HP:0010747)2.82496479
17Aplasia/Hypoplasia of the spleen (HP:0010451)2.82002859
18Abnormal pancreas size (HP:0012094)2.80383091
19Congenital stationary night blindness (HP:0007642)2.79064286
20Genetic anticipation (HP:0003743)2.78848595
21True hermaphroditism (HP:0010459)2.74952762
22Abolished electroretinogram (ERG) (HP:0000550)2.74612798
23Decreased circulating renin level (HP:0003351)2.71896256
24Preauricular pit (HP:0004467)2.68710505
25Periauricular skin pits (HP:0100277)2.68710505
26Abnormal rod and cone electroretinograms (HP:0008323)2.68087982
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.66114009
28Stenosis of the external auditory canal (HP:0000402)2.65642797
29Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.63438550
30Gait imbalance (HP:0002141)2.60217261
31Abnormality of the proximal phalanges of the hand (HP:0009834)2.55840777
32Hepatoblastoma (HP:0002884)2.54937302
33Short 4th metacarpal (HP:0010044)2.54369063
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54369063
35Diastasis recti (HP:0001540)2.51654029
36Agitation (HP:0000713)2.47146928
37Neonatal hypoglycemia (HP:0001998)2.45183372
38Anomalous pulmonary venous return (HP:0010772)2.43757940
39Abnormality of the middle phalanges of the toes (HP:0010183)2.43019701
40Megalencephaly (HP:0001355)2.42186120
41Enlarged kidneys (HP:0000105)2.39173090
42Abnormality of the frontal sinuses (HP:0002687)2.39089364
43Small hand (HP:0200055)2.38867925
44Congenital primary aphakia (HP:0007707)2.38654719
45Specific learning disability (HP:0001328)2.36454770
46Bony spicule pigmentary retinopathy (HP:0007737)2.34077704
47Abnormality of the corticospinal tract (HP:0002492)2.28307737
48Nephrogenic diabetes insipidus (HP:0009806)2.27775759
49Hypoplasia of the ulna (HP:0003022)2.27194654
50Bulbous nose (HP:0000414)2.25666774
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24249740
52Neoplasm of the adrenal cortex (HP:0100641)2.19150912
53Clumsiness (HP:0002312)2.18644702
54Limb dystonia (HP:0002451)2.18355703
55Tubular atrophy (HP:0000092)2.18154577
56Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.16553129
57Vaginal atresia (HP:0000148)2.14248211
58Hyperphosphatemia (HP:0002905)2.13645575
59Abnormality of the 4th metacarpal (HP:0010012)2.12001322
60Abnormality of the renal collecting system (HP:0004742)2.08228041
61Abnormality of the pulmonary veins (HP:0011718)2.08185175
62Abnormality of DNA repair (HP:0003254)2.06262289
63Abnormality of renal resorption (HP:0011038)2.05868482
64Genital tract atresia (HP:0001827)2.05422239
65Paralysis (HP:0003470)2.05411220
66Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.04628995
67Epileptic encephalopathy (HP:0200134)2.04426256
68Optic nerve hypoplasia (HP:0000609)2.03187516
69Abnormality of cells of the erythroid lineage (HP:0012130)2.02605843
70Cystic liver disease (HP:0006706)2.01946328
71Short hallux (HP:0010109)2.01854735
72Polyphagia (HP:0002591)2.01760580
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01628002
74Abnormality of the phalanges of the 5th finger (HP:0004213)1.99940860
75Poor coordination (HP:0002370)1.99658328
76Chronic hepatic failure (HP:0100626)1.99021854
77Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97974236
78Degeneration of the lateral corticospinal tracts (HP:0002314)1.97974236
79Aplasia/Hypoplasia of the patella (HP:0006498)1.97918893
80Hypoplasia of dental enamel (HP:0006297)1.97699044
81Abnormality of renal excretion (HP:0011036)1.97223090
82Hyperthyroidism (HP:0000836)1.96905721
83Aplasia/hypoplasia of the femur (HP:0005613)1.95906297
84Syncope (HP:0001279)1.95640515
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.95600429
86Rib fusion (HP:0000902)1.95030287
87Aplasia/Hypoplasia of the hallux (HP:0008362)1.92531350
88Abnormality of the renal cortex (HP:0011035)1.90585795
89Symphalangism affecting the phalanges of the hand (HP:0009773)1.90182019
90Fibular aplasia (HP:0002990)1.89917798
91Male pseudohermaphroditism (HP:0000037)1.87522432
92Patellar aplasia (HP:0006443)1.86919500
93Impaired vibration sensation in the lower limbs (HP:0002166)1.85706366
94Pendular nystagmus (HP:0012043)1.84045796
95Growth hormone deficiency (HP:0000824)1.81640146
96Polydipsia (HP:0001959)1.81523106
97Abnormal drinking behavior (HP:0030082)1.81523106
98Hypoplasia of the uterus (HP:0000013)1.80379063
99Skin pits (HP:0100276)1.79882150
100Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.78874925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.78968105
2STK163.09058130
3FRK3.07724589
4STK392.49773240
5MAP2K72.47253010
6CASK2.44970021
7MAP3K42.43702544
8RPS6KA22.38738296
9SGK22.08612994
10PRKD32.08263199
11SGK2232.04066242
12SGK4942.04066242
13BMPR1B1.98178375
14TAOK31.93462880
15GRK11.86542284
16RPS6KA61.80848451
17ADRBK21.78529862
18TLK11.77326246
19NTRK21.73642976
20DYRK21.73356307
21MARK11.69441781
22RPS6KC11.66889190
23RPS6KL11.66889190
24NTRK31.62646625
25PINK11.57036510
26BRAF1.44997999
27CDK191.42092896
28MARK21.36795361
29SGK31.36453772
30AKT31.35405290
31MAPK131.31841800
32PRKCG1.31229833
33SIK21.27371400
34GRK71.25280313
35MAP2K41.23036391
36ACVR1B1.19057458
37EPHA41.16064122
38WNK11.15805111
39TAF11.15517163
40DYRK31.13464909
41PIK3CA1.11098511
42TNIK1.10514886
43WNK31.10314064
44MUSK1.08773920
45CAMK1G1.05878750
46PAK31.05596833
47CAMK1D1.01023963
48NUAK11.00546594
49STK110.99827127
50MAP3K90.91420021
51CAMK10.90899014
52ARAF0.89659017
53EPHB20.84012027
54ADRBK10.83821564
55PNCK0.82534264
56DMPK0.79332111
57PRKACA0.77458922
58TYRO30.77368159
59INSRR0.71280117
60OXSR10.70911315
61CDK50.70503270
62CSNK1G20.69913716
63BCKDK0.68994441
64PRKCH0.65562057
65SGK10.63015306
66MAPK150.61015656
67CAMKK10.59014912
68DYRK1A0.58863542
69CAMK40.57899532
70TIE10.57776226
71MINK10.57774180
72ERBB20.55690113
73PRKD20.55642667
74MAP2K20.53905222
75PHKG20.53431497
76PHKG10.53431497
77CAMK2A0.51316961
78PIM20.50758104
79GRK50.50715026
80AURKA0.50474083
81DYRK1B0.49748219
82OBSCN0.49552096
83RPS6KA10.49547668
84PRKCE0.49433799
85ZAK0.49004967
86CAMKK20.47578307
87ICK0.46249023
88PRKACG0.45117239
89PRKCZ0.44590387
90PRKAA10.43574209
91MAP3K110.43071069
92RPS6KA30.43009559
93PRKCQ0.42330815
94PKN10.41212135
95PLK20.40242223
96AKT10.39603604
97PRKCI0.37774215
98CSNK1A10.37184266
99CSNK1A1L0.37139164
100PRKCA0.36874315

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.10189786
2Phototransduction_Homo sapiens_hsa047442.86523125
3Cardiac muscle contraction_Homo sapiens_hsa042602.62979590
4Oxidative phosphorylation_Homo sapiens_hsa001902.53728167
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.40024795
6Morphine addiction_Homo sapiens_hsa050322.18802195
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10428212
8Glutamatergic synapse_Homo sapiens_hsa047242.06352828
9Cholinergic synapse_Homo sapiens_hsa047252.06010775
10Parkinsons disease_Homo sapiens_hsa050122.05479765
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00636067
12Circadian entrainment_Homo sapiens_hsa047131.95875055
13Ribosome_Homo sapiens_hsa030101.91340236
14Serotonergic synapse_Homo sapiens_hsa047261.80363274
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80204086
16Dopaminergic synapse_Homo sapiens_hsa047281.77212765
17Alzheimers disease_Homo sapiens_hsa050101.68537795
18GABAergic synapse_Homo sapiens_hsa047271.68436608
19Cocaine addiction_Homo sapiens_hsa050301.66603790
20Oxytocin signaling pathway_Homo sapiens_hsa049211.66416352
21Insulin secretion_Homo sapiens_hsa049111.61317658
22Linoleic acid metabolism_Homo sapiens_hsa005911.60514946
23Axon guidance_Homo sapiens_hsa043601.57976037
24Hedgehog signaling pathway_Homo sapiens_hsa043401.54340571
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53990499
26Gastric acid secretion_Homo sapiens_hsa049711.49196764
27Basal cell carcinoma_Homo sapiens_hsa052171.45913870
28Renin secretion_Homo sapiens_hsa049241.41093961
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39771667
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37073124
31Huntingtons disease_Homo sapiens_hsa050161.35361543
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32206567
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28389174
34Olfactory transduction_Homo sapiens_hsa047401.16414283
35Amphetamine addiction_Homo sapiens_hsa050311.14549697
36Taste transduction_Homo sapiens_hsa047421.14326685
37Long-term depression_Homo sapiens_hsa047301.13171310
38Synaptic vesicle cycle_Homo sapiens_hsa047211.07876221
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04567683
40Retinol metabolism_Homo sapiens_hsa008301.04109568
41Steroid biosynthesis_Homo sapiens_hsa001001.02207757
42Melanoma_Homo sapiens_hsa052181.02128723
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02013070
44Dorso-ventral axis formation_Homo sapiens_hsa043200.99824318
45Alcoholism_Homo sapiens_hsa050340.98849385
46MAPK signaling pathway_Homo sapiens_hsa040100.96399618
47Collecting duct acid secretion_Homo sapiens_hsa049660.95998715
48cAMP signaling pathway_Homo sapiens_hsa040240.94133787
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.93039261
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92390973
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91795300
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90073503
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.89071491
54Ether lipid metabolism_Homo sapiens_hsa005650.87650112
55Chemical carcinogenesis_Homo sapiens_hsa052040.85777570
56Long-term potentiation_Homo sapiens_hsa047200.82764280
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82334838
58Dilated cardiomyopathy_Homo sapiens_hsa054140.79806748
59Homologous recombination_Homo sapiens_hsa034400.78632733
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.78450063
61Wnt signaling pathway_Homo sapiens_hsa043100.77882778
62Sulfur relay system_Homo sapiens_hsa041220.76894738
63Nitrogen metabolism_Homo sapiens_hsa009100.76384846
64Ovarian steroidogenesis_Homo sapiens_hsa049130.76360143
65Calcium signaling pathway_Homo sapiens_hsa040200.75484839
66Selenocompound metabolism_Homo sapiens_hsa004500.75280277
67Hippo signaling pathway_Homo sapiens_hsa043900.74319333
68Melanogenesis_Homo sapiens_hsa049160.72726165
69Notch signaling pathway_Homo sapiens_hsa043300.71356723
70Basal transcription factors_Homo sapiens_hsa030220.67236081
71Fanconi anemia pathway_Homo sapiens_hsa034600.66080435
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63732011
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63035727
74Type II diabetes mellitus_Homo sapiens_hsa049300.62239036
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.61792897
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.61372790
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59882975
78Rap1 signaling pathway_Homo sapiens_hsa040150.59120010
79Ras signaling pathway_Homo sapiens_hsa040140.58676671
80Gap junction_Homo sapiens_hsa045400.58402120
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58261563
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57608266
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57342466
84Sulfur metabolism_Homo sapiens_hsa009200.56887215
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56880234
86Protein export_Homo sapiens_hsa030600.56793971
87Tryptophan metabolism_Homo sapiens_hsa003800.56408954
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55374226
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54106468
90Glycerolipid metabolism_Homo sapiens_hsa005610.53918737
91Peroxisome_Homo sapiens_hsa041460.52579844
92Vitamin digestion and absorption_Homo sapiens_hsa049770.52463402
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51980420
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51309668
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51219221
96Regulation of autophagy_Homo sapiens_hsa041400.50610122
97Systemic lupus erythematosus_Homo sapiens_hsa053220.48611310
98Salivary secretion_Homo sapiens_hsa049700.48269551
99RNA degradation_Homo sapiens_hsa030180.46930316
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45805250

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