ZNF304

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein functions as a transcriptional repressor that recruits a corepressor complex to stimulate promoter hypermethylation and transcriptional silencing of target genes. Expression of this gene is upregulated in colorectal, ovarian and breast cancer, and this gene may promote cancer cell survival, growth and invasion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.76709171
2piRNA metabolic process (GO:0034587)5.66081390
3pre-miRNA processing (GO:0031054)5.08218558
4histone H2A acetylation (GO:0043968)5.06001284
5nuclear pore organization (GO:0006999)4.97552199
6hyperosmotic salinity response (GO:0042538)4.89811638
7regulation of histone H3-K9 methylation (GO:0051570)4.71527836
8meiotic cell cycle (GO:0051321)4.37949322
9synapsis (GO:0007129)4.31708460
10negative regulation of histone methylation (GO:0031061)4.27049255
11regulation of NFAT protein import into nucleus (GO:0051532)4.21040801
12DNA synthesis involved in DNA repair (GO:0000731)4.15244822
13mitotic sister chromatid cohesion (GO:0007064)4.11686189
14regulation of RNA export from nucleus (GO:0046831)4.10019842
15pore complex assembly (GO:0046931)4.02950184
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.98341457
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.98341457
18DNA methylation involved in gamete generation (GO:0043046)3.93576589
19meiotic chromosome segregation (GO:0045132)3.90498959
20single strand break repair (GO:0000012)3.69842973
21ncRNA catabolic process (GO:0034661)3.68603814
22regulation of meiosis I (GO:0060631)3.65773661
23spliceosomal tri-snRNP complex assembly (GO:0000244)3.57383376
24dosage compensation (GO:0007549)3.49782416
25mitotic chromosome condensation (GO:0007076)3.49506678
26pyrimidine dimer repair (GO:0006290)3.46940307
27monoubiquitinated protein deubiquitination (GO:0035520)3.46826928
28stress granule assembly (GO:0034063)3.45057753
29chromosome organization involved in meiosis (GO:0070192)3.41838555
30female gamete generation (GO:0007292)3.32486084
31protein localization to chromosome (GO:0034502)3.29939877
32sister chromatid cohesion (GO:0007062)3.28985475
33hypotonic response (GO:0006971)3.26705040
34histone mRNA catabolic process (GO:0071044)3.26657486
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23225755
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.23225755
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23225755
38nucleus organization (GO:0006997)3.22434477
39synaptonemal complex assembly (GO:0007130)3.22247613
40carnitine shuttle (GO:0006853)3.21506334
41membrane disassembly (GO:0030397)3.20011037
42nuclear envelope disassembly (GO:0051081)3.20011037
43metaphase plate congression (GO:0051310)3.18826563
44negative regulation of meiosis (GO:0045835)3.16912930
45protein localization to chromosome, centromeric region (GO:0071459)3.12269448
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11847883
47regulation of spindle organization (GO:0090224)3.11485986
48regulation of DNA methylation (GO:0044030)3.09384028
49histone H4 acetylation (GO:0043967)3.08279053
50histone H3-K4 methylation (GO:0051568)3.07097658
51mitotic nuclear envelope disassembly (GO:0007077)3.06408805
52histone-serine phosphorylation (GO:0035404)3.01523424
53oocyte development (GO:0048599)3.01166380
54resolution of meiotic recombination intermediates (GO:0000712)2.97542867
55regulation of nucleobase-containing compound transport (GO:0032239)2.96501084
56positive regulation of chromosome segregation (GO:0051984)2.93441378
57cerebral cortex neuron differentiation (GO:0021895)2.93268964
58positive regulation of macroautophagy (GO:0016239)2.90283504
59gene silencing by RNA (GO:0031047)2.87280502
60relaxation of smooth muscle (GO:0044557)2.86834506
61ER overload response (GO:0006983)2.84948059
62double-strand break repair via nonhomologous end joining (GO:0006303)2.83597747
63non-recombinational repair (GO:0000726)2.83597747
64regulation of histone methylation (GO:0031060)2.78620421
65regulation of microtubule depolymerization (GO:0031114)2.76477515
66DNA methylation (GO:0006306)2.75076224
67DNA alkylation (GO:0006305)2.75076224
68establishment of integrated proviral latency (GO:0075713)2.73918414
69vesicle transport along microtubule (GO:0047496)2.73846917
70synaptonemal complex organization (GO:0070193)2.73587362
71oogenesis (GO:0048477)2.70820351
72protein localization to kinetochore (GO:0034501)2.68062938
73establishment of chromosome localization (GO:0051303)2.68040221
74inositol phosphate catabolic process (GO:0071545)2.66600261
75histone H3-K9 methylation (GO:0051567)2.62511698
76meiotic nuclear division (GO:0007126)2.62138111
77regulation of response to osmotic stress (GO:0047484)2.60732130
78nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58683486
79mitotic metaphase plate congression (GO:0007080)2.58666093
80ncRNA 3-end processing (GO:0043628)2.57580213
81N-terminal protein amino acid acetylation (GO:0006474)2.56869514
82histone demethylation (GO:0016577)2.56550803
83atrial septum morphogenesis (GO:0060413)2.55653700
84peptidyl-lysine trimethylation (GO:0018023)2.53601512
85regulation of energy homeostasis (GO:2000505)2.52957803
86histone acetylation (GO:0016573)2.51983825
87protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.51918539
88mismatch repair (GO:0006298)2.50842284
89peptidyl-lysine dimethylation (GO:0018027)2.50511243
90histone H4-K16 acetylation (GO:0043984)2.50422785
91fatty acid homeostasis (GO:0055089)2.48107701
92organelle transport along microtubule (GO:0072384)2.47811727
93gastrulation with mouth forming second (GO:0001702)2.47380568
94positive regulation of translational initiation (GO:0045948)2.46952493
95histone lysine methylation (GO:0034968)2.44770876
96telomere maintenance via telomerase (GO:0007004)2.44562288
97post-embryonic morphogenesis (GO:0009886)2.43715507
98negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.43188728
99male meiosis I (GO:0007141)2.42642407
100mRNA splice site selection (GO:0006376)2.42263094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62072577
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.04173539
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.91876773
4E2F7_22180533_ChIP-Seq_HELA_Human3.67899162
5* NOTCH1_21737748_ChIP-Seq_TLL_Human3.37337033
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34697764
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.21099225
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11744650
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02316616
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.98207198
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.84953654
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83053585
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61103069
14* ELK1_19687146_ChIP-ChIP_HELA_Human2.51614596
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.50874209
16PADI4_21655091_ChIP-ChIP_MCF-7_Human2.28539756
17YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20455585
18VDR_23849224_ChIP-Seq_CD4+_Human2.17265168
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16413376
20DCP1A_22483619_ChIP-Seq_HELA_Human2.11870321
21* ETS1_20019798_ChIP-Seq_JURKAT_Human2.06477789
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.05220607
23DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.04870755
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.01089684
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96880771
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93665206
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.90634839
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.90352698
29CIITA_25753668_ChIP-Seq_RAJI_Human1.88993123
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86651773
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84992144
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84776146
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.82042892
34PKCTHETA_26484144_Chip-Seq_BREAST_Human1.80148105
35AR_21909140_ChIP-Seq_LNCAP_Human1.76128683
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75527380
37ZNF274_21170338_ChIP-Seq_K562_Hela1.75360890
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72377237
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66586424
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.65346230
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61247087
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61139381
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.60664073
44* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58357517
45TFEB_21752829_ChIP-Seq_HELA_Human1.56339779
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54623427
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.49170077
48KDM5A_27292631_Chip-Seq_BREAST_Human1.49097692
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.46631663
50FOXP3_21729870_ChIP-Seq_TREG_Human1.45720954
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44359232
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40819982
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37335174
54MYC_18940864_ChIP-ChIP_HL60_Human1.35443765
55TTF2_22483619_ChIP-Seq_HELA_Human1.32769632
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31171902
57XRN2_22483619_ChIP-Seq_HELA_Human1.30549844
58GABP_19822575_ChIP-Seq_HepG2_Human1.29283440
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27907151
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27462645
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27459634
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27440404
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.26293093
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25116084
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24291536
66EWS_26573619_Chip-Seq_HEK293_Human1.23948556
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23502187
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21139758
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.17216214
70FUS_26573619_Chip-Seq_HEK293_Human1.17025879
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16995075
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16462204
73IGF1R_20145208_ChIP-Seq_DFB_Human1.14168067
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09748996
75CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05567948
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05371311
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05222744
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05222744
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03908535
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00748727
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98292802
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96985548
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94948375
84FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93347015
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92311611
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91255137
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91069820
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90529606
89SALL4_22934838_ChIP-ChIP_CD34+_Human0.90200246
90MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90068384
91MYC_22102868_ChIP-Seq_BL_Human0.89662353
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87481825
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.86973499
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86364020
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83444743
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82388401
97CHD1_26751641_Chip-Seq_LNCaP_Human0.81839403
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80961945
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80542789
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80342546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry4.32589163
2MP0008057_abnormal_DNA_replication4.23384023
3MP0008058_abnormal_DNA_repair4.12402044
4MP0005423_abnormal_somatic_nervous3.89435172
5MP0003718_maternal_effect3.11050603
6MP0003941_abnormal_skin_development2.82502321
7MP0003077_abnormal_cell_cycle2.75706170
8MP0008877_abnormal_DNA_methylation2.62019159
9MP0003111_abnormal_nucleus_morphology2.61642827
10MP0010094_abnormal_chromosome_stability2.56129982
11MP0003693_abnormal_embryo_hatching2.50416544
12MP0001730_embryonic_growth_arrest2.04179913
13MP0003221_abnormal_cardiomyocyte_apopto2.00564107
14MP0004957_abnormal_blastocyst_morpholog1.97304678
15MP0004084_abnormal_cardiac_muscle1.94053391
16MP0001293_anophthalmia1.89534763
17MP0008932_abnormal_embryonic_tissue1.86425625
18MP0004808_abnormal_hematopoietic_stem1.86008342
19MP0008007_abnormal_cellular_replicative1.82786996
20MP0002210_abnormal_sex_determination1.73046394
21MP0002084_abnormal_developmental_patter1.66765333
22MP0000350_abnormal_cell_proliferation1.64569623
23MP0002396_abnormal_hematopoietic_system1.63398924
24MP0000462_abnormal_digestive_system1.62389227
25MP0002102_abnormal_ear_morphology1.59339992
26MP0001929_abnormal_gametogenesis1.56022942
27MP0000569_abnormal_digit_pigmentation1.55665927
28MP0003950_abnormal_plasma_membrane1.55117939
29MP0005380_embryogenesis_phenotype1.53293429
30MP0001672_abnormal_embryogenesis/_devel1.53293429
31MP0008995_early_reproductive_senescence1.51371885
32MP0006292_abnormal_olfactory_placode1.42391817
33MP0002735_abnormal_chemical_nociception1.42364957
34MP0010307_abnormal_tumor_latency1.42108071
35MP0002085_abnormal_embryonic_tissue1.36340945
36MP0001697_abnormal_embryo_size1.34916790
37MP0006035_abnormal_mitochondrial_morpho1.34569421
38MP0002234_abnormal_pharynx_morphology1.32736993
39MP0001145_abnormal_male_reproductive1.31222458
40MP0008789_abnormal_olfactory_epithelium1.29393985
41MP0002092_abnormal_eye_morphology1.28301762
42MP0000537_abnormal_urethra_morphology1.27909136
43MP0000653_abnormal_sex_gland1.27100761
44MP0005499_abnormal_olfactory_system1.26540163
45MP0005394_taste/olfaction_phenotype1.26540163
46MP0003984_embryonic_growth_retardation1.24003829
47MP0002088_abnormal_embryonic_growth/wei1.23614614
48MP0003755_abnormal_palate_morphology1.23000678
49MP0002233_abnormal_nose_morphology1.20041163
50MP0004233_abnormal_muscle_weight1.19227788
51MP0004036_abnormal_muscle_relaxation1.18127099
52MP0002080_prenatal_lethality1.17013943
53MP0002009_preneoplasia1.17004317
54MP0000733_abnormal_muscle_development1.15357211
55MP0003699_abnormal_female_reproductive1.14881947
56MP0000750_abnormal_muscle_regeneration1.14509875
57MP0003935_abnormal_craniofacial_develop1.13049844
58MP0005076_abnormal_cell_differentiation1.12180406
59MP0003656_abnormal_erythrocyte_physiolo1.09903672
60MP0003861_abnormal_nervous_system1.09209881
61MP0004197_abnormal_fetal_growth/weight/1.09166535
62MP0003567_abnormal_fetal_cardiomyocyte1.07579627
63MP0010352_gastrointestinal_tract_polyps1.07297499
64MP0009703_decreased_birth_body1.06949941
65MP0005395_other_phenotype1.06546065
66MP0003786_premature_aging1.03770586
67MP0000313_abnormal_cell_death1.01853776
68MP0009672_abnormal_birth_weight0.97845633
69MP0010030_abnormal_orbit_morphology0.96590182
70MP0002086_abnormal_extraembryonic_tissu0.94367911
71MP0008961_abnormal_basal_metabolism0.94006639
72MP0000631_abnormal_neuroendocrine_gland0.92435241
73MP0001915_intracranial_hemorrhage0.89274061
74MP0000762_abnormal_tongue_morphology0.88526114
75MP0002090_abnormal_vision0.88503886
76MP0002161_abnormal_fertility/fecundity0.85691350
77MP0002177_abnormal_outer_ear0.84748203
78MP0005621_abnormal_cell_physiology0.83918071
79MP0001286_abnormal_eye_development0.83078354
80MP0005391_vision/eye_phenotype0.82023260
81MP0001177_atelectasis0.81367451
82MP0000428_abnormal_craniofacial_morphol0.80305351
83MP0002089_abnormal_postnatal_growth/wei0.80114858
84MP0004145_abnormal_muscle_electrophysio0.79621590
85MP0001119_abnormal_female_reproductive0.79538271
86MP0010630_abnormal_cardiac_muscle0.78449650
87MP0001340_abnormal_eyelid_morphology0.77683060
88MP0003698_abnormal_male_reproductive0.77424292
89MP0002116_abnormal_craniofacial_bone0.76981788
90MP0002697_abnormal_eye_size0.75973810
91MP0003385_abnormal_body_wall0.75245438
92MP0003119_abnormal_digestive_system0.74760733
93MP0005384_cellular_phenotype0.73807226
94MP0002081_perinatal_lethality0.73578651
95MP0000432_abnormal_head_morphology0.70338204
96MP0003646_muscle_fatigue0.69715954
97MP0003880_abnormal_central_pattern0.68727107
98MP0004133_heterotaxia0.68291543
99MP0001529_abnormal_vocalization0.66995634
100MP0000049_abnormal_middle_ear0.66677187

Predicted human phenotypes

RankGene SetZ-score
1Carpal bone hypoplasia (HP:0001498)5.83221848
2Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.36873990
3Papillary thyroid carcinoma (HP:0002895)4.34757030
4Abnormal hair whorl (HP:0010721)3.88894976
5Limb-girdle muscle atrophy (HP:0003797)3.75220609
6Hand muscle atrophy (HP:0009130)3.56195453
7Colon cancer (HP:0003003)3.54205107
8Muscle fiber splitting (HP:0003555)3.45921125
9Medulloblastoma (HP:0002885)3.44339788
10Spinal muscular atrophy (HP:0007269)3.42128433
11Volvulus (HP:0002580)3.38784475
12Microvesicular hepatic steatosis (HP:0001414)3.34596306
13Ependymoma (HP:0002888)3.21428067
14Hip contracture (HP:0003273)3.18711367
15Heterotopia (HP:0002282)3.17185107
16Abnormality of the phalanges of the hallux (HP:0010057)3.16284533
17Urethral obstruction (HP:0000796)3.08550842
18Short tibia (HP:0005736)2.96696192
19Broad-based gait (HP:0002136)2.88760190
20Gonadotropin excess (HP:0000837)2.77549590
21Knee flexion contracture (HP:0006380)2.77522757
22Rimmed vacuoles (HP:0003805)2.73975241
23Aplasia of the musculature (HP:0100854)2.73402504
24Fetal akinesia sequence (HP:0001989)2.71800603
25Hip dysplasia (HP:0001385)2.71719106
26Aplasia/Hypoplasia involving the musculature (HP:0001460)2.67080680
27Difficulty running (HP:0009046)2.66148706
28Abnormality of the astrocytes (HP:0100707)2.65338478
29Astrocytoma (HP:0009592)2.65338478
30Obstructive sleep apnea (HP:0002870)2.64053612
31Rhabdomyosarcoma (HP:0002859)2.62307662
32Agnosia (HP:0010524)2.61977471
33Abnormality of the septum pellucidum (HP:0007375)2.52818207
34Thyroid carcinoma (HP:0002890)2.52394842
35Spinal cord compression (HP:0002176)2.51625612
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.49493323
37Dysmetric saccades (HP:0000641)2.45935461
38Shoulder girdle muscle weakness (HP:0003547)2.42603366
39Urinary urgency (HP:0000012)2.42005949
40Upper limb amyotrophy (HP:0009129)2.41534600
41Distal upper limb amyotrophy (HP:0007149)2.41534600
42Abnormality of the calf musculature (HP:0001430)2.38463431
43Scapular winging (HP:0003691)2.38449567
44Hypoplasia of the odontoid process (HP:0003311)2.38433424
45Horizontal nystagmus (HP:0000666)2.36758892
46Cortical dysplasia (HP:0002539)2.35479964
47Abnormality of the distal phalanges of the toes (HP:0010182)2.34888643
48Abnormality of the shoulder girdle musculature (HP:0001435)2.34783578
49Limited hip movement (HP:0008800)2.34744156
50Proximal amyotrophy (HP:0007126)2.34052307
51Abnormality of the musculature of the hand (HP:0001421)2.32987975
52Midline defect of the nose (HP:0004122)2.29566923
53Diaphragmatic weakness (HP:0009113)2.29546996
54Glioma (HP:0009733)2.28004870
55Chronic hepatic failure (HP:0100626)2.27739889
56Lip pit (HP:0100267)2.26376308
57Abnormality of the hip-girdle musculature (HP:0001445)2.22873012
58Abnormality of the musculature of the pelvis (HP:0001469)2.22873012
59Supernumerary spleens (HP:0009799)2.22492757
60Depressed nasal tip (HP:0000437)2.20608723
61Absent septum pellucidum (HP:0001331)2.18965098
62Barrel-shaped chest (HP:0001552)2.15337479
63Postural tremor (HP:0002174)2.12017350
64Abnormality of chromosome segregation (HP:0002916)2.11122930
65Neoplasm of striated muscle (HP:0009728)2.09864087
66Increased nuchal translucency (HP:0010880)2.08635505
67Neoplasm of the oral cavity (HP:0100649)2.08368526
68Abnormality of the salivary glands (HP:0010286)2.07702910
69Septate vagina (HP:0001153)2.06967825
70Abnormality of the middle phalanges of the toes (HP:0010183)2.05373290
71Rough bone trabeculation (HP:0100670)2.04765488
72Distal lower limb muscle weakness (HP:0009053)2.04485216
73Apathy (HP:0000741)2.04484585
74Pelvic girdle muscle weakness (HP:0003749)2.03506231
75Protruding tongue (HP:0010808)1.99138237
76Flat acetabular roof (HP:0003180)1.98673734
77Abnormality of the odontoid process (HP:0003310)1.98194242
78Impulsivity (HP:0100710)1.98021309
79Abnormal lung lobation (HP:0002101)1.97752496
80Progressive external ophthalmoplegia (HP:0000590)1.91878283
81Sparse lateral eyebrow (HP:0005338)1.90545987
82Disproportionate short-trunk short stature (HP:0003521)1.89198967
83Abnormality of the vocal cords (HP:0008777)1.87336595
84Tetraparesis (HP:0002273)1.85791484
85Low anterior hairline (HP:0000294)1.85100390
86Large earlobe (HP:0009748)1.84711939
87Skull defect (HP:0001362)1.83868187
88Aplasia cutis congenita (HP:0001057)1.83697368
89Submucous cleft hard palate (HP:0000176)1.82801151
90Drooling (HP:0002307)1.81026644
91Vertebral arch anomaly (HP:0008438)1.80020082
92Fair hair (HP:0002286)1.79891042
93Diminished motivation (HP:0000745)1.78354499
94Tubulointerstitial nephritis (HP:0001970)1.77881527
95Overlapping toe (HP:0001845)1.76274668
96Anteriorly placed anus (HP:0001545)1.74020294
97Birth length less than 3rd percentile (HP:0003561)1.68552461
98Excessive salivation (HP:0003781)1.68287543
99Multiple enchondromatosis (HP:0005701)1.68171591
100Hammertoe (HP:0001765)1.67085082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK4.00157963
2BRD43.56149913
3SRPK13.22743101
4CDK123.10695386
5EIF2AK32.55063835
6CLK12.50476268
7ERBB32.34350281
8BRSK22.13195450
9MAP3K102.08724076
10STK32.01288056
11PBK1.88728621
12TSSK61.87558868
13PRPF4B1.78720883
14STK161.76306222
15MAP3K21.63029900
16TNIK1.59695287
17LATS11.56048493
18RPS6KA41.47769265
19MARK11.46410596
20EPHA31.45394775
21STK41.44306188
22CDC71.43910260
23CASK1.43587504
24DYRK31.41329459
25STK38L1.39004208
26NEK61.31785293
27MAP3K91.31259065
28SIK21.30881237
29BUB11.27260762
30MAP3K71.25711534
31BCR1.25452817
32WEE11.20834907
33TAF11.19164837
34MAP3K131.15275727
35CDK31.08775486
36CHEK21.07433013
37YES11.07223270
38MAP3K41.03367411
39OBSCN1.02148185
40NME10.99387811
41CDK70.99078035
42PLK10.97524946
43MKNK20.96968955
44CSNK1G10.96403774
45CHEK10.95541930
46PRKAA10.95273314
47CDK90.94183667
48NEK90.93710018
49ATM0.93148875
50MAP3K140.91266702
51CDK60.90805948
52AURKA0.89480785
53CHUK0.88998483
54KSR20.88894925
55MKNK10.88581812
56ERBB40.88384455
57KSR10.86864070
58AKT30.86040154
59CDK20.85146417
60NLK0.84378395
61MTOR0.83458858
62UHMK10.83429263
63CDK10.82965582
64CAMK1D0.82549792
65SGK20.81938838
66CSNK1A1L0.78335130
67IRAK10.77287098
68PASK0.77246352
69PLK30.76979728
70MAP2K70.76768883
71RPS6KB10.75961956
72PNCK0.73787600
73TESK20.73328750
74MAP3K50.72155594
75MELK0.70086279
76MAPK100.66969385
77VRK10.66632011
78GSK3B0.65608147
79ZAK0.62746776
80PIM10.61594255
81LATS20.59085217
82CSNK1G20.58930939
83FER0.58725249
84BRSK10.58640453
85ATR0.55973692
86CSNK1D0.55881820
87SGK2230.52458867
88SGK4940.52458867
89RAF10.52094726
90CSNK1E0.51566297
91CSNK1G30.50922483
92PRKAA20.49437200
93FGFR30.48826382
94PAK20.48124276
95TBK10.47321609
96DYRK1B0.47135696
97CAMK1G0.46934816
98MAPK140.46887213
99PLK40.45964466
100SGK30.45778746

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047103.22716171
2Non-homologous end-joining_Homo sapiens_hsa034503.13621747
3Cell cycle_Homo sapiens_hsa041103.00855526
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98422888
5RNA transport_Homo sapiens_hsa030132.91850914
6mRNA surveillance pathway_Homo sapiens_hsa030152.59300340
7RNA polymerase_Homo sapiens_hsa030202.49180955
8Base excision repair_Homo sapiens_hsa034102.40188384
9Spliceosome_Homo sapiens_hsa030402.39231737
10RNA degradation_Homo sapiens_hsa030182.35154766
11Mismatch repair_Homo sapiens_hsa034302.32123739
12Basal transcription factors_Homo sapiens_hsa030222.25850971
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74763988
14Regulation of autophagy_Homo sapiens_hsa041401.74696205
15mTOR signaling pathway_Homo sapiens_hsa041501.74340201
16Dorso-ventral axis formation_Homo sapiens_hsa043201.69939351
17Inositol phosphate metabolism_Homo sapiens_hsa005621.67332762
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65106779
19Selenocompound metabolism_Homo sapiens_hsa004501.64980426
20Oocyte meiosis_Homo sapiens_hsa041141.58686680
21Protein export_Homo sapiens_hsa030601.54802931
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54150503
23DNA replication_Homo sapiens_hsa030301.40527561
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.38454991
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36589892
26Nucleotide excision repair_Homo sapiens_hsa034201.36193342
27p53 signaling pathway_Homo sapiens_hsa041151.32706779
28Fanconi anemia pathway_Homo sapiens_hsa034601.26501718
29MicroRNAs in cancer_Homo sapiens_hsa052061.24339936
30FoxO signaling pathway_Homo sapiens_hsa040681.20596344
31Small cell lung cancer_Homo sapiens_hsa052221.19851417
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19272333
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17069261
34Viral carcinogenesis_Homo sapiens_hsa052031.15492218
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12191834
36Epstein-Barr virus infection_Homo sapiens_hsa051691.09129837
37Hedgehog signaling pathway_Homo sapiens_hsa043401.04539292
38Endometrial cancer_Homo sapiens_hsa052131.01178353
39Hepatitis B_Homo sapiens_hsa051611.00622238
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98594524
41Adherens junction_Homo sapiens_hsa045200.97403972
42Chronic myeloid leukemia_Homo sapiens_hsa052200.95885536
43TGF-beta signaling pathway_Homo sapiens_hsa043500.94194380
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91696024
45Prostate cancer_Homo sapiens_hsa052150.90947591
46ErbB signaling pathway_Homo sapiens_hsa040120.88733691
47Herpes simplex infection_Homo sapiens_hsa051680.85736080
48Thyroid cancer_Homo sapiens_hsa052160.85469809
49Colorectal cancer_Homo sapiens_hsa052100.82827686
50Lysine degradation_Homo sapiens_hsa003100.82822996
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80095227
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79829007
53Basal cell carcinoma_Homo sapiens_hsa052170.78358417
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76439288
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74554257
56Renal cell carcinoma_Homo sapiens_hsa052110.70764408
57AMPK signaling pathway_Homo sapiens_hsa041520.70665022
58Prolactin signaling pathway_Homo sapiens_hsa049170.68348387
59Acute myeloid leukemia_Homo sapiens_hsa052210.67988984
60Insulin signaling pathway_Homo sapiens_hsa049100.66987900
61HTLV-I infection_Homo sapiens_hsa051660.66875725
62Notch signaling pathway_Homo sapiens_hsa043300.65817992
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.65479095
64Non-small cell lung cancer_Homo sapiens_hsa052230.65255383
65Gap junction_Homo sapiens_hsa045400.64931730
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64687796
67Measles_Homo sapiens_hsa051620.58910804
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58471213
69Purine metabolism_Homo sapiens_hsa002300.57898232
70Hippo signaling pathway_Homo sapiens_hsa043900.57757285
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57704460
72Pancreatic cancer_Homo sapiens_hsa052120.57464673
73Wnt signaling pathway_Homo sapiens_hsa043100.54707417
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54045753
75Influenza A_Homo sapiens_hsa051640.52714992
76B cell receptor signaling pathway_Homo sapiens_hsa046620.52283439
77Pyrimidine metabolism_Homo sapiens_hsa002400.51809560
78Ovarian steroidogenesis_Homo sapiens_hsa049130.50919847
79Insulin resistance_Homo sapiens_hsa049310.49783084
80Pathways in cancer_Homo sapiens_hsa052000.48494760
81Viral myocarditis_Homo sapiens_hsa054160.47096800
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46483546
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.44314683
84Dilated cardiomyopathy_Homo sapiens_hsa054140.43482361
85Glioma_Homo sapiens_hsa052140.41937876
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.41785481
87Phototransduction_Homo sapiens_hsa047440.41076518
88HIF-1 signaling pathway_Homo sapiens_hsa040660.39194004
89Homologous recombination_Homo sapiens_hsa034400.38615558
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37100204
91Legionellosis_Homo sapiens_hsa051340.36075876
92Alcoholism_Homo sapiens_hsa050340.35366916
93MAPK signaling pathway_Homo sapiens_hsa040100.33753900
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32643940
95Shigellosis_Homo sapiens_hsa051310.31980563
96Systemic lupus erythematosus_Homo sapiens_hsa053220.31077894
97Type II diabetes mellitus_Homo sapiens_hsa049300.30940347
98Proteoglycans in cancer_Homo sapiens_hsa052050.30367513
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.27682183
100Melanoma_Homo sapiens_hsa052180.26497785

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