ZNF317

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.30033412
2negative thymic T cell selection (GO:0045060)3.78839936
3response to muramyl dipeptide (GO:0032495)3.73842582
4positive regulation of B cell differentiation (GO:0045579)3.59994872
5negative T cell selection (GO:0043383)3.59050653
6negative regulation of erythrocyte differentiation (GO:0045647)3.58311728
7regulation of B cell receptor signaling pathway (GO:0050855)3.56006443
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50386783
9positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.48723746
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38153751
11negative regulation of cell killing (GO:0031342)3.38153751
12negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.32453489
13regulation of chromatin binding (GO:0035561)3.25377504
14mitotic sister chromatid cohesion (GO:0007064)3.20795551
15tolerance induction (GO:0002507)3.14664734
16B cell receptor signaling pathway (GO:0050853)3.14547039
17nuclear pore complex assembly (GO:0051292)3.12877275
18positive regulation of granulocyte differentiation (GO:0030854)3.12135689
19positive regulation of interferon-beta production (GO:0032728)3.10505675
20positive thymic T cell selection (GO:0045059)3.08933018
21interferon-gamma production (GO:0032609)3.08139654
22regulation of B cell differentiation (GO:0045577)3.06674526
23ribosome assembly (GO:0042255)3.05154148
24positive regulation by symbiont of host defense response (GO:0052509)3.02193424
25modulation by symbiont of host defense response (GO:0052031)3.02193424
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02193424
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02193424
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.02193424
29modulation by symbiont of host immune response (GO:0052553)3.02193424
30positive regulation of interferon-alpha production (GO:0032727)3.01524867
31B cell homeostasis (GO:0001782)3.01502648
32regulation of gamma-delta T cell activation (GO:0046643)3.00662980
33T cell migration (GO:0072678)3.00643185
34regulation of interferon-alpha production (GO:0032647)2.97178251
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87188060
36response to interleukin-15 (GO:0070672)2.87013400
37thymic T cell selection (GO:0045061)2.86244074
38positive regulation of alpha-beta T cell proliferation (GO:0046641)2.85106740
39regulation of T-helper 1 cell differentiation (GO:0045625)2.84138800
40NIK/NF-kappaB signaling (GO:0038061)2.83065295
41regulation of interferon-beta production (GO:0032648)2.81573367
42T cell selection (GO:0045058)2.81233769
43response to peptidoglycan (GO:0032494)2.79904948
44regulation of alpha-beta T cell proliferation (GO:0046640)2.78399694
45regulation of gamma-delta T cell differentiation (GO:0045586)2.74994433
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72010027
47negative regulation of T-helper cell differentiation (GO:0045623)2.72010027
48positive T cell selection (GO:0043368)2.67857782
49leukocyte aggregation (GO:0070486)2.67031110
50cellular response to interleukin-15 (GO:0071350)2.66493246
51positive regulation of interleukin-2 production (GO:0032743)2.62286701
52regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60887542
53B cell mediated immunity (GO:0019724)2.60588087
54nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.59059141
55alternative mRNA splicing, via spliceosome (GO:0000380)2.57607171
56histone H3-K4 trimethylation (GO:0080182)2.57268752
57nuclear pore organization (GO:0006999)2.56821598
58T cell homeostasis (GO:0043029)2.56819973
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55848818
60germinal center formation (GO:0002467)2.55799325
61megakaryocyte development (GO:0035855)2.55693404
62immunoglobulin mediated immune response (GO:0016064)2.54058287
63CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.52884686
64neutrophil activation involved in immune response (GO:0002283)2.52768584
65negative regulation of interleukin-12 production (GO:0032695)2.49976101
66regulation of interferon-beta biosynthetic process (GO:0045357)2.48371684
67positive regulation of protein homooligomerization (GO:0032464)2.47603929
68nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.46853594
69cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.46468032
70histone H3-K36 demethylation (GO:0070544)2.45880584
71lymphocyte homeostasis (GO:0002260)2.45864213
72regulation of RNA export from nucleus (GO:0046831)2.44571615
73response to dsRNA (GO:0043331)2.43883106
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.43584405
75regulation of B cell apoptotic process (GO:0002902)2.41967422
76macrophage activation involved in immune response (GO:0002281)2.39305614
77type I interferon signaling pathway (GO:0060337)2.35926152
78cellular response to type I interferon (GO:0071357)2.35926152
79transcription from mitochondrial promoter (GO:0006390)2.35541276
80cellular extravasation (GO:0045123)2.35271269
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.34762754
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.34423017
83negative regulation of mRNA processing (GO:0050686)2.33856248
84response to type I interferon (GO:0034340)2.33531460
85IMP biosynthetic process (GO:0006188)2.33502605
86cellular response to interleukin-4 (GO:0071353)2.33129907
87ncRNA 3-end processing (GO:0043628)2.32023106
88regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.31932895
89regulation of interleukin-2 biosynthetic process (GO:0045076)2.31612522
90cellular response to exogenous dsRNA (GO:0071360)2.30988348
91regulation of defense response to virus by host (GO:0050691)2.30443684
92pore complex assembly (GO:0046931)2.30026205
93regulation of response to interferon-gamma (GO:0060330)2.29835187
94negative regulation of innate immune response (GO:0045824)2.29655119
95spliceosomal tri-snRNP complex assembly (GO:0000244)2.29590553
96definitive hemopoiesis (GO:0060216)2.29501667
97negative regulation of mRNA metabolic process (GO:1903312)2.29151398
98antigen processing and presentation of endogenous antigen (GO:0019883)2.28833743
99regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.26375431
100necroptotic process (GO:0070266)2.26339924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.79607414
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.99539774
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73059914
4MYC_22102868_ChIP-Seq_BL_Human3.25383256
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.25257743
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.00396445
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.00122757
8ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.52173502
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48254435
10MYB_26560356_Chip-Seq_TH2_Human2.37161715
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33040152
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30616034
13CIITA_25753668_ChIP-Seq_RAJI_Human2.25369813
14VDR_23849224_ChIP-Seq_CD4+_Human2.23801359
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17740807
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15448479
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15036014
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.14039988
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.11509939
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09442271
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04415642
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04177570
23SPI1_23547873_ChIP-Seq_NB4_Human2.01185255
24MYB_26560356_Chip-Seq_TH1_Human2.00230949
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98759025
26TFEB_21752829_ChIP-Seq_HELA_Human1.96438767
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95969815
28VDR_21846776_ChIP-Seq_THP-1_Human1.91988484
29FOXP3_21729870_ChIP-Seq_TREG_Human1.90892215
30* EST1_17652178_ChIP-ChIP_JURKAT_Human1.85677144
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84779352
32MAF_26560356_Chip-Seq_TH1_Human1.82159236
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82070909
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.81125089
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.80998954
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76833846
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76721232
38* ETS1_20019798_ChIP-Seq_JURKAT_Human1.74953683
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73930604
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73426086
41SCL_19346495_ChIP-Seq_HPC-7_Human1.71038622
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69937137
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.69230399
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68798862
45RUNX_20019798_ChIP-Seq_JUKART_Human1.65821300
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62995086
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60641570
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56470788
49DCP1A_22483619_ChIP-Seq_HELA_Human1.56205875
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55711632
51* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55341740
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53438695
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53412795
54UTX_26944678_Chip-Seq_JUKART_Human1.53376942
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51477651
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.50593555
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50551081
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49273777
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47181339
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45287496
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44608660
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43994876
63GATA3_27048872_Chip-Seq_THYMUS_Human1.43341269
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42995039
65KDM5A_27292631_Chip-Seq_BREAST_Human1.42693146
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41708687
67ELK1_19687146_ChIP-ChIP_HELA_Human1.41392399
68VDR_24763502_ChIP-Seq_THP-1_Human1.40830479
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40147395
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36868790
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36112684
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34561359
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31971662
74TCF7_22412390_ChIP-Seq_EML_Mouse1.30799706
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28372345
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26566031
77GABP_19822575_ChIP-Seq_HepG2_Human1.25672856
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25102679
79MAF_26560356_Chip-Seq_TH2_Human1.24841628
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24345582
81XRN2_22483619_ChIP-Seq_HELA_Human1.21567378
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21560265
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21133393
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20983321
85TTF2_22483619_ChIP-Seq_HELA_Human1.19732033
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.19561059
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17279070
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14440489
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14358513
90PU_27001747_Chip-Seq_BMDM_Mouse1.12688659
91GATA3_26560356_Chip-Seq_TH2_Human1.10605286
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07226385
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07158427
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.06530649
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.05731730
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05346677
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05239850
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04297197
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03958066
100SPI1_23127762_ChIP-Seq_K562_Human1.02996404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.23473644
2MP0008057_abnormal_DNA_replication3.13220757
3MP0003763_abnormal_thymus_physiology3.04099341
4MP0001835_abnormal_antigen_presentation2.88879320
5MP0000685_abnormal_immune_system2.59885718
6MP0001800_abnormal_humoral_immune2.54503729
7MP0005000_abnormal_immune_tolerance2.46569637
8MP0005671_abnormal_response_to2.44959146
9MP0002396_abnormal_hematopoietic_system2.41491400
10MP0003656_abnormal_erythrocyte_physiolo2.34584881
11MP0002009_preneoplasia2.25743486
12MP0002452_abnormal_antigen_presenting2.21780338
13MP0005387_immune_system_phenotype2.21233454
14MP0001790_abnormal_immune_system2.21233454
15MP0003111_abnormal_nucleus_morphology2.17575781
16MP0002398_abnormal_bone_marrow2.16725131
17MP0010094_abnormal_chromosome_stability2.08460157
18MP0002723_abnormal_immune_serum2.06981887
19MP0002420_abnormal_adaptive_immunity2.04231788
20MP0002148_abnormal_hypersensitivity_rea2.03660061
21MP0001819_abnormal_immune_cell2.02817791
22MP0000703_abnormal_thymus_morphology2.01229035
23MP0002166_altered_tumor_susceptibility2.00220534
24MP0001853_heart_inflammation1.98635931
25MP0009333_abnormal_splenocyte_physiolog1.97564246
26MP0003172_abnormal_lysosome_physiology1.95816182
27MP0000689_abnormal_spleen_morphology1.92553378
28MP0002405_respiratory_system_inflammati1.92544490
29MP0008058_abnormal_DNA_repair1.91129078
30MP0002419_abnormal_innate_immunity1.89852596
31MP0003724_increased_susceptibility_to1.86203735
32MP0002722_abnormal_immune_system1.85346109
33MP0003303_peritoneal_inflammation1.82179284
34MP0002138_abnormal_hepatobiliary_system1.81229429
35MP0005310_abnormal_salivary_gland1.80100124
36MP0004808_abnormal_hematopoietic_stem1.79832648
37MP0000716_abnormal_immune_system1.79235003
38MP0005025_abnormal_response_to1.76776988
39MP0003300_gastrointestinal_ulcer1.68774505
40MP0004947_skin_inflammation1.68721317
41MP0003693_abnormal_embryo_hatching1.65027250
42MP0005360_urolithiasis1.64233153
43MP0009278_abnormal_bone_marrow1.61189887
44MP0002006_tumorigenesis1.60122599
45MP0009785_altered_susceptibility_to1.59684901
46MP0002429_abnormal_blood_cell1.59093582
47MP0008007_abnormal_cellular_replicative1.54341155
48MP0003077_abnormal_cell_cycle1.52552286
49MP0001873_stomach_inflammation1.50398558
50MP0010352_gastrointestinal_tract_polyps1.47301622
51MP0001845_abnormal_inflammatory_respons1.36002331
52MP0005451_abnormal_body_composition1.35691170
53MP0002163_abnormal_gland_morphology1.33134749
54MP0005464_abnormal_platelet_physiology1.32541677
55MP0010307_abnormal_tumor_latency1.29348121
56MP0010155_abnormal_intestine_physiology1.29012784
57MP0005397_hematopoietic_system_phenotyp1.27361740
58MP0001545_abnormal_hematopoietic_system1.27361740
59MP0003786_premature_aging1.24229178
60MP0005076_abnormal_cell_differentiation1.21196801
61MP0005075_abnormal_melanosome_morpholog1.20898236
62MP0002019_abnormal_tumor_incidence1.20291636
63MP0004957_abnormal_blastocyst_morpholog1.15677792
64MP0002254_reproductive_system_inflammat1.15032434
65MP0000015_abnormal_ear_pigmentation1.14618830
66MP0009840_abnormal_foam_cell1.13715643
67MP0000465_gastrointestinal_hemorrhage1.08856056
68MP0008995_early_reproductive_senescence1.04185605
69MP0000350_abnormal_cell_proliferation1.02761446
70MP0001533_abnormal_skeleton_physiology1.00927917
71MP0000313_abnormal_cell_death1.00521016
72MP0004381_abnormal_hair_follicle0.97763475
73MP0008961_abnormal_basal_metabolism0.97209583
74MP0009764_decreased_sensitivity_to0.96557101
75MP0000490_abnormal_crypts_of0.92154320
76MP0008469_abnormal_protein_level0.92144878
77MP0002877_abnormal_melanocyte_morpholog0.89882679
78MP0008260_abnormal_autophagy0.88965393
79MP0000858_altered_metastatic_potential0.86664107
80MP0006082_CNS_inflammation0.86548893
81MP0002132_abnormal_respiratory_system0.85561287
82MP0000604_amyloidosis0.82744963
83MP0003828_pulmonary_edema0.81190621
84MP0009765_abnormal_xenobiotic_induced0.80862648
85MP0001730_embryonic_growth_arrest0.79312505
86MP0009763_increased_sensitivity_to0.78589541
87MP0001697_abnormal_embryo_size0.73673588
88MP0002998_abnormal_bone_remodeling0.73492528
89MP0005621_abnormal_cell_physiology0.69853783
90MP0003453_abnormal_keratinocyte_physiol0.67735611
91MP0004264_abnormal_extraembryonic_tissu0.67213979
92MP0005379_endocrine/exocrine_gland_phen0.66819904
93MP0008877_abnormal_DNA_methylation0.66408422
94MP0001919_abnormal_reproductive_system0.66384744
95MP0002086_abnormal_extraembryonic_tissu0.65092340
96MP0009115_abnormal_fat_cell0.64165420
97MP0004197_abnormal_fetal_growth/weight/0.63008723
98MP0002080_prenatal_lethality0.62564076
99MP0003221_abnormal_cardiomyocyte_apopto0.61531634
100MP0003448_altered_tumor_morphology0.61190085

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.03937477
2Elevated erythrocyte sedimentation rate (HP:0003565)3.90142152
3IgG deficiency (HP:0004315)3.88647896
4Panhypogammaglobulinemia (HP:0003139)3.88093407
5Recurrent viral infections (HP:0004429)3.75333109
6Abnormality of T cell physiology (HP:0011840)3.69715662
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.61157401
8Fatigue (HP:0012378)3.59372695
9Recurrent fungal infections (HP:0002841)3.42042700
10Severe combined immunodeficiency (HP:0004430)3.41313905
11Urethral obstruction (HP:0000796)3.39117284
12Combined immunodeficiency (HP:0005387)3.36090566
13Abnormality of T cells (HP:0002843)3.31580543
14Eczematoid dermatitis (HP:0000976)3.27407699
15Autoimmune hemolytic anemia (HP:0001890)3.27140487
16T lymphocytopenia (HP:0005403)3.07037044
17Recurrent cutaneous fungal infections (HP:0011370)3.06577982
18Chronic mucocutaneous candidiasis (HP:0002728)3.06577982
19Abnormality of T cell number (HP:0011839)3.01824867
20Agammaglobulinemia (HP:0004432)2.88957628
21Recurrent bacterial skin infections (HP:0005406)2.87440242
22Recurrent abscess formation (HP:0002722)2.87413268
23Granulocytopenia (HP:0001913)2.77916131
24Viral hepatitis (HP:0006562)2.74224537
25Mediastinal lymphadenopathy (HP:0100721)2.73318070
26Increased IgE level (HP:0003212)2.71085176
27Lymphopenia (HP:0001888)2.70415726
28Autoimmune thrombocytopenia (HP:0001973)2.66659270
29Abnormality of cells of the lymphoid lineage (HP:0012140)2.62779508
30Meningitis (HP:0001287)2.57675757
31IgA deficiency (HP:0002720)2.54489749
32Colitis (HP:0002583)2.53926773
33Pustule (HP:0200039)2.52486596
34B lymphocytopenia (HP:0010976)2.46967290
35Eosinophilia (HP:0001880)2.44737981
36Abnormality of homocysteine metabolism (HP:0010919)2.42429476
37Homocystinuria (HP:0002156)2.42429476
38Leukocytosis (HP:0001974)2.42252347
39Papilloma (HP:0012740)2.40666127
40Verrucae (HP:0200043)2.40666127
41Increased IgM level (HP:0003496)2.39654036
42IgM deficiency (HP:0002850)2.39316891
43Abnormality of the prostate (HP:0008775)2.38935096
44Lymphoma (HP:0002665)2.38364661
45Myelodysplasia (HP:0002863)2.38004549
46Abnormality of the columella (HP:0009929)2.37153550
47Squamous cell carcinoma (HP:0002860)2.36125417
48Abnormality of eosinophils (HP:0001879)2.35645453
49Abnormality of macrophages (HP:0004311)2.35282577
50Thrombocytosis (HP:0001894)2.33524650
51Entropion (HP:0000621)2.33409028
52Menstrual irregularities (HP:0000858)2.28127213
53Abnormality of B cell number (HP:0010975)2.27437847
54Encephalitis (HP:0002383)2.24522642
55Poikiloderma (HP:0001029)2.22617924
56Gastrointestinal inflammation (HP:0004386)2.21166809
57Vasculitis (HP:0002633)2.20813079
58Inflammation of the large intestine (HP:0002037)2.19859351
59Prostate neoplasm (HP:0100787)2.18506634
60Acute myeloid leukemia (HP:0004808)2.18484346
61Amaurosis fugax (HP:0100576)2.17683924
62Aplasia/Hypoplasia of the thymus (HP:0010515)2.14210213
63Recurrent skin infections (HP:0001581)2.13456428
64Albinism (HP:0001022)2.13398099
65Basal cell carcinoma (HP:0002671)2.13202172
66Progressive external ophthalmoplegia (HP:0000590)2.12998737
67Subacute progressive viral hepatitis (HP:0006572)2.10525360
68Myositis (HP:0100614)2.04872783
69Chest pain (HP:0100749)2.02884922
70Hypoplasia of the thymus (HP:0000778)2.02182511
71Gastrointestinal infarctions (HP:0005244)2.01324490
72Limb hypertonia (HP:0002509)2.01068057
73Abnormality of the preputium (HP:0100587)2.00000970
74Retrobulbar optic neuritis (HP:0100654)1.99119132
75Optic neuritis (HP:0100653)1.99119132
76Pulmonary infiltrates (HP:0002113)1.97881856
77Chronic diarrhea (HP:0002028)1.96511805
78Prominent nose (HP:0000448)1.93494132
79Hepatitis (HP:0012115)1.93155806
80Papillary thyroid carcinoma (HP:0002895)1.90914629
81Submucous cleft hard palate (HP:0000176)1.90875343
82Urticaria (HP:0001025)1.90529631
83Stomach cancer (HP:0012126)1.89943857
84Cutaneous melanoma (HP:0012056)1.87753982
85Hematochezia (HP:0002573)1.84083388
86Petechiae (HP:0000967)1.83308077
87Reduced antithrombin III activity (HP:0001976)1.83100464
88Abnormality of male internal genitalia (HP:0000022)1.82622566
89Cellulitis (HP:0100658)1.81274095
90Gastrointestinal stroma tumor (HP:0100723)1.81032885
91Neutropenia (HP:0001875)1.79564113
92Arterial thrombosis (HP:0004420)1.79517213
93Neoplasm of the tracheobronchial system (HP:0100552)1.79131279
94Somatic mutation (HP:0001428)1.79088902
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77919450
96Volvulus (HP:0002580)1.77400645
97Microvesicular hepatic steatosis (HP:0001414)1.76876546
98Abnormality of chromosome stability (HP:0003220)1.76141065
99Abnormality of the nasal septum (HP:0000419)1.76105579
100Abnormality of the thymus (HP:0000777)1.75925659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.35853334
2PRPF4B3.17331622
3MAP4K12.84671362
4MAP3K142.81149871
5CDK122.65268774
6SMG12.60391282
7TAOK32.51272192
8IRAK12.10546613
9EIF2AK11.93182114
10TSSK61.92561728
11TEC1.87191490
12IKBKE1.83394864
13IRAK41.78699395
14TXK1.77078028
15ITK1.76518036
16PASK1.75831166
17JAK31.68742928
18IKBKB1.66191404
19BRD41.65254993
20SIK31.60392905
21TBK11.56419505
22BTK1.53805285
23NUAK11.44911412
24CLK11.41198433
25JAK11.36317497
26TYK21.35218159
27SCYL21.33328318
28FES1.32321136
29MAP3K101.30143427
30NLK1.29793034
31RIPK41.29122418
32TAF11.27951583
33IRAK21.23911258
34NME21.22337714
35CDC71.22289597
36EIF2AK21.21022778
37PIM11.18614446
38HCK1.17499701
39BRSK21.11426378
40IRAK31.10198193
41CDK41.09308472
42MKNK21.09152267
43ZAP701.08275586
44GRK61.06124009
45FGR1.05743941
46CDK91.03775550
47MAP2K31.00814422
48CSK0.97199453
49MARK30.96661574
50ALK0.95532623
51MAP3K30.95457552
52TNK20.95151680
53SYK0.94995364
54CDK80.92577729
55BUB10.89862507
56LYN0.89174561
57EPHA30.88479459
58FGFR40.87357542
59ATR0.87311388
60CHUK0.86565942
61MAPK110.86172716
62LCK0.84703187
63CDK60.84612988
64STK100.84126851
65CHEK10.82960877
66TRIM280.78228028
67CCNB10.77635724
68EEF2K0.76678422
69FGFR30.75609931
70MAP3K130.74858788
71CSF1R0.74383723
72MELK0.71784686
73CDK70.71114249
74ICK0.70494816
75MAP3K20.70464329
76SRPK10.66810596
77EPHB10.66776162
78SIK20.66324821
79MKNK10.65360491
80RAF10.64964539
81HIPK20.61770677
82BLK0.61320895
83JAK20.59039410
84FLT30.55164545
85STK40.52478909
86BMPR20.51874938
87STK240.50722640
88PKN20.50236146
89TTK0.49102845
90MAP3K80.47030980
91ATM0.45348588
92KIT0.44575071
93SIK10.43483328
94MAP3K10.43192928
95MATK0.41403399
96RPS6KA10.41313188
97ABL10.40856580
98PIM20.40847732
99PRKCQ0.39816087
100CHEK20.39293284

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.89723428
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.42551827
3Allograft rejection_Homo sapiens_hsa053302.39196755
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.36624026
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31307688
6B cell receptor signaling pathway_Homo sapiens_hsa046622.25513693
7Measles_Homo sapiens_hsa051622.23017155
8Autoimmune thyroid disease_Homo sapiens_hsa053202.20663906
9Herpes simplex infection_Homo sapiens_hsa051682.14268054
10Graft-versus-host disease_Homo sapiens_hsa053321.96108088
11Spliceosome_Homo sapiens_hsa030401.94731048
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88614886
13T cell receptor signaling pathway_Homo sapiens_hsa046601.88376170
14Type I diabetes mellitus_Homo sapiens_hsa049401.88154702
15Asthma_Homo sapiens_hsa053101.87135975
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87031265
17Leishmaniasis_Homo sapiens_hsa051401.82838843
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79554544
19Osteoclast differentiation_Homo sapiens_hsa043801.72777298
20RNA transport_Homo sapiens_hsa030131.72066750
21Influenza A_Homo sapiens_hsa051641.67136438
22Viral myocarditis_Homo sapiens_hsa054161.59164715
23Hepatitis B_Homo sapiens_hsa051611.57832940
24Legionellosis_Homo sapiens_hsa051341.56431447
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55395110
26Epstein-Barr virus infection_Homo sapiens_hsa051691.55228867
27Acute myeloid leukemia_Homo sapiens_hsa052211.52201722
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46882377
29mRNA surveillance pathway_Homo sapiens_hsa030151.46567906
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46154703
31Other glycan degradation_Homo sapiens_hsa005111.39543088
32Non-homologous end-joining_Homo sapiens_hsa034501.37852370
33Antigen processing and presentation_Homo sapiens_hsa046121.37844772
34TNF signaling pathway_Homo sapiens_hsa046681.37790114
35Apoptosis_Homo sapiens_hsa042101.35531669
36RNA degradation_Homo sapiens_hsa030181.34684324
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.34089970
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30406087
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25660394
40Shigellosis_Homo sapiens_hsa051311.24927370
41Viral carcinogenesis_Homo sapiens_hsa052031.22601933
42Chronic myeloid leukemia_Homo sapiens_hsa052201.22521531
43Tuberculosis_Homo sapiens_hsa051521.20555575
44Toxoplasmosis_Homo sapiens_hsa051451.20402505
45Hematopoietic cell lineage_Homo sapiens_hsa046401.18639993
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15414348
47DNA replication_Homo sapiens_hsa030301.15137407
48Basal transcription factors_Homo sapiens_hsa030221.09512059
49HTLV-I infection_Homo sapiens_hsa051661.04710485
50Hepatitis C_Homo sapiens_hsa051601.03757772
51p53 signaling pathway_Homo sapiens_hsa041151.02149139
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01625829
53Staphylococcus aureus infection_Homo sapiens_hsa051501.01582621
54Cell cycle_Homo sapiens_hsa041100.97571492
55Non-small cell lung cancer_Homo sapiens_hsa052230.96343728
56Rheumatoid arthritis_Homo sapiens_hsa053230.94486521
57Pancreatic cancer_Homo sapiens_hsa052120.83101716
58Selenocompound metabolism_Homo sapiens_hsa004500.81451749
59Base excision repair_Homo sapiens_hsa034100.81175750
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81040034
61Fanconi anemia pathway_Homo sapiens_hsa034600.79729830
62Bladder cancer_Homo sapiens_hsa052190.79216209
63Prostate cancer_Homo sapiens_hsa052150.79005259
64mTOR signaling pathway_Homo sapiens_hsa041500.76651924
65RNA polymerase_Homo sapiens_hsa030200.76254804
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75250830
67MicroRNAs in cancer_Homo sapiens_hsa052060.73881348
68Homologous recombination_Homo sapiens_hsa034400.72953925
69Chemokine signaling pathway_Homo sapiens_hsa040620.72589581
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72544454
71Prolactin signaling pathway_Homo sapiens_hsa049170.66348306
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.64299279
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.63191000
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62063555
75FoxO signaling pathway_Homo sapiens_hsa040680.60902304
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60448794
77Renal cell carcinoma_Homo sapiens_hsa052110.60247294
78Colorectal cancer_Homo sapiens_hsa052100.59828273
79Lysosome_Homo sapiens_hsa041420.58719035
80Systemic lupus erythematosus_Homo sapiens_hsa053220.58472806
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56020067
82Inositol phosphate metabolism_Homo sapiens_hsa005620.55287106
83African trypanosomiasis_Homo sapiens_hsa051430.55155630
84N-Glycan biosynthesis_Homo sapiens_hsa005100.54373060
85Thyroid cancer_Homo sapiens_hsa052160.52384720
86Malaria_Homo sapiens_hsa051440.48921268
87Pyrimidine metabolism_Homo sapiens_hsa002400.44956920
88Sphingolipid metabolism_Homo sapiens_hsa006000.44420006
89Lysine degradation_Homo sapiens_hsa003100.43904033
90Pertussis_Homo sapiens_hsa051330.43590021
91Nucleotide excision repair_Homo sapiens_hsa034200.43526315
92Proteasome_Homo sapiens_hsa030500.42765131
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39909026
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38610065
95Endometrial cancer_Homo sapiens_hsa052130.37987094
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36017394
97One carbon pool by folate_Homo sapiens_hsa006700.35978939
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34549815
99Small cell lung cancer_Homo sapiens_hsa052220.33368228
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31735904

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